Ann Appl Stat 2021 Dec 21;15(4):1652-1672. Epub 2021 Dec 21.
Department of Biostatistics, University of California, Los Angeles.
Single nucleotide polymorphism (SNP) set analysis aggregates both common and rare variants and tests for association between phenotype(s) of interest and a set. However, multiple SNP-sets, such as genes, pathways, or sliding windows are usually investigated across the whole genome in which all groups are tested separately, followed by multiple testing adjustments. We propose a novel method to prioritize SNP-sets in a joint multivariate variance component model. Read More