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Ann Clin Biochem 2020 Jun 1:4563220935140. Epub 2020 Jun 1.

Dokuz Eylul University Faculty of Medicine.

Ann Clin Biochem 2020 Jun 1:4563220935622. Epub 2020 Jun 1.

Ninewells Hospital.

Ann Intern Med 2020 06 2. Epub 2020 Jun 2.

New York, New York (C.M.C.).

Ann Intern Med 2020 06 2. Epub 2020 Jun 2.

Vanderbilt University Medical Center, Nashville, Tennessee (M.S.K.).

Ann Intern Med 2020 06;172(11):W134-W135

Mount Sinai School of Medicine, New York, New York (G.E.F.).

Ann Intern Med 2020 Jun;172(11):ED11

Ann Emerg Med 2020 Jun;75(6):778-780

Massachusetts General Hospital, Boston, MA.

Ann Intern Med 2020 Jun 26;172(11):W136-W139. Epub 2020 May 26.

Providence Portland Medical Center, Portland, Oregon (J.P.).

Ann Biomed Eng 2020 May 21. Epub 2020 May 21.

Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, USA.

Ann Clin Biochem 2020 May 21:4563220933303. Epub 2020 May 21.

Guy's and Saint Thomas' NHS Foundation Trust.

Ann Clin Biochem 2020 May 19:4563220931876. Epub 2020 May 19.

The London Clinic.

Ann Clin Biochem 2020 May 19:4563220931885. Epub 2020 May 19.

King's College Hospital Department of Biochemistry.

Ann Coloproctol 2020 Apr 30;36(2):64. Epub 2020 Apr 30.

Co-Chief-Editor of Annals of Coloproctology Secretary General of APFCP.

Ann Coloproctol 2020 Apr 30;36(2):63. Epub 2020 Apr 30.

Editor-in-Chief of Annals of Coloproctology.

Ann Intern Med 2020 May;172(10):ED10

From Michigan Medicine and VA Ann Arbor Healthcare System, Ann Arbor, Michigan (D.H.W, V.C).

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Ann Intern Med 2020 05;172(10):W124-W125

NYU School of Medicine, New York, New York (M.N.).

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Ann Intern Med 2020 05 12;172(10):CG1. Epub 2020 May 12.

Thomas Jefferson University, Philadelphia, Pennsylvania (G.J.M., H.H.W.).

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Ann Intern Med 2020 05;172(10):W126-W127

Brown University, Providence, Rhode Island (G.S.).

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Ann Intern Med 2020 May;172(10):ED10

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Ann Intern Med 2020 May 12. Epub 2020 May 12.

Savona, Italy (L.B., I.P.).

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Ann Intern Med 2020 06 12;172(11):OC1. Epub 2020 May 12.

The Johns Hopkins Hospital, Baltimore, Maryland (R.M.).

Ann Intern Med 2020 05 12;172(10):W132-W133. Epub 2020 May 12.

Oregon Health & Science University, Portland, Oregon (Z.G.J.).

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Ann Transl Med 2020 Apr;8(8):553

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

One of the most commonly used systems for grading liver function in hepatocellular carcinoma (HCC) patients is the Child-Pugh (CP) score. However, the CP scoring system is not without its shortcomings: for example, the cut-off values for the parameters are calculated arbitrarily and the assessment of ascites and hepatic encephalopathy is subjective. More recently, an alternative to traditional CP grade has emerged in the form of albumin-bilirubin (ALBI) grade. Read More

Ann Transl Med 2020 Apr;8(8):542

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: Hepatocellular carcinoma (HCC) is a common cancer worldwide and prognosis for patients with the disease remains poor. Most patients are diagnosed at an advanced stage and are only eligible for palliative therapy. As a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor (VEGFR2-TKI), apatinib has a certain antitumor effect for a variety of solid tumors. Read More

Ann Transl Med 2020 Apr;8(8):541

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: Neutrophil-to-lymphocyte ratio (NLR) is considered as a prognostic predictor of hepatocellular carcinoma (HCC). However, its prognostic ability is still controversial. This study aimed to evaluate the prognostic value of NLR changes in HCC patients undergoing transarterial chemoembolization (TACE). Read More

Ann Transl Med 2020 Apr;8(8):540

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: Sorafenib and transarterial chemoembolization (TACE) are the standard treatments recommended by guidelines for unresectable hepatocellular carcinoma (HCC). Although previous studies have shown the combination therapy of sorafenib and TACE to be safe, there is no consensus regarding its efficacy. This systematic review and meta-analysis, which was based on the findings of comparative clinical trials, was conducted to provide up-to-date and comprehensive information about the efficacy of combination therapy versus TACE monotherapy in unresectable HCC. Read More

Ann Transl Med 2020 Apr;8(8):539

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Backgrounds: The Child-Pugh score is a scoring system used to measure liver function and predict postoperative outcomes in patients with hepatocellular carcinoma (HCC). Recently, the Albumin-Bilirubin (ALBI) grade has been proposed for the evaluation of hepatic reserve function in HCC. This study aimed to assess and compare the capability of ALBI grade and Child-Pugh score in predicting overall survival (OS). Read More

Ann Transl Med 2020 Apr;8(8):538

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: The Child-Pugh score has been used extensively to assess hepatic function and predict post-treatment outcomes in patients with hepatocellular carcinoma (HCC). Recently, the albumin-bilirubin (ALBI) grade has been put forward as an objective method of evaluating liver function and predicting overall survival (OS) in HCC patients. Transarterial chemoembolization (TACE) is considered to be effective in prolonging OS among intermediate-stage HCC patients. Read More

Ann Transl Med 2020 Apr;8(8):537

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: Albumin-Bilirubin (ALBI) grade has been proposed for the evaluation of liver function in hepatocellular carcinoma (HCC). The combination therapy of transarterial chemoembolization (TACE) and sorafenib is widely used for HCC patients with preserved liver function; our study aimed to investigate and compare the discriminating values of ALBI grade and Child-Pugh score in overall survival (OS).

Methods: A total of 173 HCC patients with preserved liver function (Child-Pugh A) were enrolled. Read More

Ann Transl Med 2020 Apr;8(8):536

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: Alpha-fetoprotein (AFP) has been extensively applied in clinical practice to detect and predict postoperative outcomes of patients with hepatocellular carcinoma (HCC). However, due to its low sensitivity and specificity, its efficacy has been questioned. Recently, novel serum biomarkers including Golgi protein 73 (GP73) and glypican-3 (GPC-3) have shown a better discriminatory ability than AFP in detecting early HCC. Read More

Ann Surg 2020 May 1. Epub 2020 May 1.

Department of Surgery, Massachusetts General Hospital, Boston, MA.

Ann Surg 2020 May 12. Epub 2020 May 12.

Surgical Endoscopy, Stony Brook, NY.

Ann Transl Med 2020 Apr;8(7):501

Dipartimento di Medicina Clinica, Sanità Pubblica, Scienze della Vita e dell'Ambiente, Università degli Studi dell'Aquila, L'Aquila, Italy.

Interest in the application of machine learning (ML) techniques to medicine is growing fast and wide because of their ability to endow decision support systems with so-called artificial intelligence, particularly in those medical disciplines that extensively rely on digital imaging. Nonetheless, achieving a pragmatic and ecological validation of medical AI systems in real-world settings is difficult, even when these systems exhibit very high accuracy in laboratory settings. This difficulty has been called the "last mile of implementation. Read More

Ann Transl Med 2020 Apr;8(7):497

Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, OH, USA.

The "novel" coronavirus disease 2019 (abbreviated "COVID-19") is the third coronavirus outbreak emerging during the past two decades. This infectious disease, sustained by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has been recently declared a global pandemic by the World Health Organization. Despite the concerning epidemiological burden, many people, including some policymakers, are underestimating this pandemic and are remaining enigmatically inactive against a human pathology which, for a combination of reasons, can be reasonably defined as a perfect storm (i. Read More

Ann Rehabil Med 2020 Apr 29;44(2):158-164. Epub 2020 Apr 29.

Department of Physical Medicine and Rehabilitation, Veterans Health Service Medical Center, Seoul, Korea.

Objective: To investigate the articles in the Annals of Rehabilitation Medicine (ARM) using a bibliometric analysis to verify whether there is a correlation between the topics of interest for expert groups and the public media.

Methods: A total of 1,088 ARM articles from the third issue of 2011 to the third issue of 2019 were analyzed. We conducted a bibliometric analysis of the articles using conventional metrics (CM) and alternative metrics (AM). Read More

Ann Glob Health 2020 Apr 29;86(1):47. Epub 2020 Apr 29.

Department of Health, Social and Welfare Studies, University of South-Eastern Norway, NO.

Background: Global health is a term often used interchangeably with international health due to overlapping similarities and unclear distinctions. While some international health supporters argue that global health as a field is unnecessary as it is simply a duplicate of international health, global health supporters argue that global health is unique; for instance, it actively includes elements of empowerment and promotes cross-border collaboration.

Objective: To investigate differences and similarities in research representing the fields of global and international health. Read More

Ann Clin Biochem 2020 May 5:4563220928355. Epub 2020 May 5.

Royal Wolverhampton Hospitals NHS Trust.

Ann Intern Med 2020 May;172(9):ED9

Ann Intern Med 2020 05;172(9):OC1

University of Michigan, Ann Arbor, Michigan (J.M.).

Ann Intern Med 2020 05;172(9):W106-W107

Mount Sinai School of Medicine, New York, New York (G.E.F.).

Ann Intern Med 2020 05;172(9):W108-W118

Icahn School of Medicine at Mount Sinai, New York, New York (L.T.).

Ann Transl Med 2020 Mar;8(6):407

Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Background: Although the cuff technique in rat lung transplantation (LTx) has a long history, it remains technically challenging. We have developed key tricks and modifications in the devices and the cuff technique that optimize the rat LTx model to achieve successful operations during a short learning period.

Methods: Altogether, 180 consecutive rats underwent orthotopic left LTx performed by a single surgeon using our modified devices and procedures. Read More

Ann Transl Med 2020 Mar;8(6):406

Department of Thoracic Surgery, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Ann Transl Med 2020 Mar;8(6):380

The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, China.

Background: Type 2 diabetes mellitus (T2DM) and hepatocellular carcinoma (HCC) are both major health problems throughout the world. It has been reported that T2DM is an independent risk factor for HCC, although the pathophysiology is still unclear.

Methods: In order to identify differentially expressed genes (DEGs) in T2DM and HCC, gene expression datasets for T2DM (GSE15653), HCC (GSE60502) and metformin-treated cells (GSE69850) were obtained from the Gene Expression Omnibus database repository. Read More

Ann Transl Med 2020 Mar;8(6):366

Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410006, China.

Background: An increasing amount of evidence has demonstrated that combined or multiple targeted therapies could bring about more durable clinical outcomes, and it is known that epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance is related to bypass activation. This study aims to explore a specific solution for third-generation EGFR-TKI resistance caused by bypass activation, and to examine the antitumor effects of the combination of a novel inhibitor CX-6258 HCl with osimertinib, along with its underlining mechanisms.

Methods: A bioinformatics analysis was performed to detect the relations between the provirus integration site for Moloney murine leukemia virus 1 (PIM1) expression and prognosis of lung cancer. Read More

Ann Transl Med 2020 Mar;8(6):358

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin 300052, China.

Background: To develop a nomogram incorporating indicator of muscle waste to prognosticate long-term mortality in liver cirrhosis (LC), and identify the prognostic impact of psoas muscle index (PMI).

Methods: A total of 251 LC patients who underwent computed tomography were included in this study. Multiple Cox regression was performed, and sex-specific nomogram models incorporating PMI were developed. Read More

Ann Transl Med 2020 Mar;8(6):352

Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.

Background: Most patients with cystitis glandularis (CG) suffer from recurrence after primary treatment. Therefore, we performed this multicenter study to clarify the recurrent risk factors and constructed a predictive nomogram for the risk of recurrence. Also, we try to investigate the correlation between CG and bladder cancer. Read More

Ann Transl Med 2020 Mar;8(6):350

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008, China.

Background: To assess the diversified effects of mechanical instability, excessive mechanical loading on subchondral bone remodeling. And to investigate the underlying cartilage degeneration and osteoarthritis (OA) progression in ipsilateral and contralateral knees, given that OA progression always affects joints bilaterally.

Methods: Anterior cruciate ligament transection (ACLT) of the left knee was used to induce OA in C57/B6 mice for 1, 3 and 6 months. Read More

Ann Transl Med 2020 Mar;8(6):333

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Background: Preeclampsia (PE) is a widespread progressive condition that can occur pregnancy and is related to high maternal morbidity and fetal mortality in the perinatal period. However, the exact mechanism responsible has not been specific. Accumulating evidence has highlighted the prominent role of the epithelial-mesenchymal transition (EMT) in the biological behaviors of PE. Read More

Ann Transl Med 2020 Mar;8(6):332

Department of Orthopedics, Peking University Third Hospital, Beijing 100191, China.

Background: Reconstruction following resection of the primary tumors of the upper cervical spine is challenging, and conventional internal implants develop complications in this region. 3D printing, also known as additive manufacturing, can produce patient-specific porous implants in a particular shape for bone defect reconstruction. This study aimed to describe the clinical outcomes of upper cervical spine reconstruction using customized 3D-printed vertebral body in 9 patients with primary tumors involving C2. Read More