904 results match your criteria Annals Of Pharmacotherapy[Journal]


Eradication of methicillin-resistant Staphylococcus aureus vaginitis with mupirocin.

DICP 1991 Dec;25(12):1331-3

Union Memorial Hospital, Baltimore, MD.

We report the case of a 54-year-old, quadriplegic woman with a methicillin-resistant Staphylococcus aureus (MRSA) vaginal infection. After failing a five-day course of intravenous vancomycin therapy, the patient was treated for ten days with mupirocin ointment applied intravaginally twice daily, which resulted in eradication of the infection. This report details a novel approach in treating MRSA vaginal infections. Read More

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December 1991

Oral vancomycin-induced rash: case report and review of the literature.

DICP 1991 Dec;25(12):1326-8

College of Pharmacy, University of Michigan, Ann Arbor 48109.

Disseminated rash and pruritus are described in an 82-year-old woman with chronic renal failure following administration of oral vancomycin hydrochloride 125 mg q6h for the treatment of Clostridium difficile colitis. Renal function was estimated to be 0.27 mL/s based on a serum creatinine of 177 mumol/L. Read More

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December 1991

Preventing medication prescribing errors.

DICP 1991 Dec;25(12):1388-94

Albany College of Pharmacy, NY.

Medication errors may arise in the manufacture, preparation, distribution, and administration of drugs. Physician prescribing errors are of particular importance as such errors have been associated with significant adverse patient outcomes. The pharmacist plays an important role in preventing such errors from reaching the patient. Read More

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December 1991

Recommendations for establishing a drug and toxicology information center in a developing country.

DICP 1991 Dec;25(12):1379-83

University of Zimbabwe Medical School, Avondale, Harare.

The purpose of this work was to formulate guidelines to help health professionals in establishing or strengthening the capabilities of drug and toxicology information centers and related facilities in developing countries. These guidelines are based on the experience of an established drug and toxicology information service in Zimbabwe which has been operating for more than ten years and on information obtained from other centers in developed countries. The guidelines provide advice rather than a unique model and should therefore be adapted rather than adopted. Read More

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December 1991

Medication usage patterns in patients with human immunodeficiency virus infection: a comparison of patient-reported medication usage with medical chart review.

DICP 1991 Dec;25(12):1374-8

Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco.

Patients infected with the human immunodeficiency virus (HIV) receive numerous medications from multiple providers. As a result, it is important that medication usage is properly documented in each patient's medical record. Lack of adequate documentation may confound a provider's assessment of drug efficacy, potentially leading to an increased incidence of drug interactions and adverse effects. Read More

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December 1991

Early individualization of tricyclic antidepressant dosing using a Bayesian pharmacokinetic model.

DICP 1991 Dec;25(12):1368-73

School of Pharmacy, University of the Pacific, Stockton, CA 95211.

Existing methods to prospectively dose tricyclic antidepressants (TCAs) require either specific test doses, precisely timed serum sampling, or both. We prospectively tested a new pharmacokinetic model that allows flexible dosing and sampling to determine maintenance requirements in patients receiving TCAs. Thirty-four patients entered the study. Read More

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December 1991

BCG and the treatment of superficial bladder cancer.

Authors:
J T Moss D Kadmon

DICP 1991 Dec;25(12):1355-67

Pharmacy Service, Department of Veterans Affairs Medical Center, Houston, TX 77030.

In this report, we review the evolution of bacillus Calmette-Guérin (BCG) immunotherapy as a legitimate form of treatment in superficial, nonmuscle-invasive bladder cancer. In the US, an estimated 45,000 new cases of bladder cancer are diagnosed each year and the annual death rate approaches 11,000. Approximately 70 percent of these cancers are superficial at the time of initial presentation. Read More

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December 1991

Indomethacin for prevention of neonatal intraventricular hemorrhage.

DICP 1991 Dec;25(12):1344-8

University of Texas, Austin.

Up to 50 percent of premature infants develop an intracerebral hemorrhage. Intracerebral hemorrhage in neonates occurs most frequently in the periventricular or intraventricular areas. Intravascular, vascular, and extravascular factors influence the development of hemorrhage. Read More

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December 1991

Topical uses of testosterone.

DICP 1991 Dec;25(12):1341-3

Department of Pharmacy, Mary Immogene Bassett Hospital, Cooperstown, New York.

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December 1991

Amiloride for lung disease in cystic fibrosis.

Authors:
A Zahaykevich

DICP 1991 Dec;25(12):1340-1

Department of Pharmacy, Spartanburg Regional Medical Center, South Carolina 29303.

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December 1991

Clonidine for growth acceleration.

Authors:
C Toy R K Middleton

DICP 1991 Dec;25(12):1339-40

Medical Service, Department of Veterans Affairs Medical Center, Martinez, California 94553.

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December 1991

Medical versus pharmaceutical continuing education: are both appropriate for the pharmacist?

DICP 1991 Dec;25(12):1336-8

Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205.

Continuing education (CE) courses in pharmacy and medicine often overlap with regard to their informational content. At the present time, however, it is feasible that two pharmacists could attend the same national meeting that has continuing medical education (CME) approval status and only one of them would receive CE credit from his state board of pharmacy. Therefore, a survey of 51 state board of pharmacy policies regarding acceptance of CME was conducted. Read More

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December 1991

Procainamide-induced pseudo-obstruction in a diabetic patient.

DICP 1991 Dec;25(12):1334-5

Department of Pharmacy, Hahnemann University, Philadelphia, PA.

We report the case of a 65-year-old black man who presented to our facility with pseudo-obstruction of the bowel within two weeks of the initiation of oral sustained-release procainamide hydrochloride therapy. The syndrome continued despite conversion to intravenous procainamide and only resolved after discontinuation of the medication. We believe that the anticholinergic properties of procainamide, coupled with the patient's diabetes, contributed to severe hypomotility of the gastrointestinal tract and, subsequently, a pseudo-obstructive state. Read More

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December 1991

Possible association of pulmonary fibrosis with mexiletine.

Authors:
C J Bero T L Rihn

DICP 1991 Dec;25(12):1329-31

Mercy Hospital of Pittsburgh, PA.

This case describes a 75-year-old man who developed pulmonary fibrosis. The onset of symptoms occurred three months after starting mexiletine. A computerized tomogram obtained eight months after initiating mexiletine documented findings consistent with chronic pulmonary fibrosis. Read More

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December 1991

Ketoconazole hepatotoxicity in a patient treated for environmental illness and systemic candidiasis.

DICP 1991 Dec;25(12):1321-5

Purdue University School of Pharmacy and Pharmacal Sciences, Lafayette, IN.

Environmental illness, a hypothesized disease caused by exposure to substances such as combustion products, pesticides, food additives, and Candida albicans, is discussed. The case of a patient with environmental illness and systemic candidiasis for six weeks with ketoconazole, liver enzyme concentrations increased. One month after discontinuation of ketoconazole, the liver enzyme concentrations decreased; however, over the next five months, liver enzymes and bilirubin increased. Read More

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December 1991

Clinical and pharmacokinetic profiles of digoxin immune Fab in four patients with renal impairment.

DICP 1991 Dec;25(12):1315-20

Department of Medicine, Duke University Medical Center, Durham, NC 27710.

Minimal pharmacokinetic data on digoxin immune Fab are currently available, especially in patients with impaired renal function. The serum concentration-time profiles of total digoxin, free digoxin, and digoxin immune Fab in four patients with moderate to severe renal impairment who received digoxin immune Fab are presented. The calculated elimination half-life of digoxin immune Fab was 25-73 hours. Read More

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December 1991

Clinical evaluation of a finger oscillometric blood pressure device.

DICP 1991 Dec;25(12):1310-4

Department of Pharmacy Services, Medical College of Virginia Hospital.

An oscillometric blood pressure (BP) device designed for recording systemic BP from a finger was compared with a random-zero, mercury-column sphygmomanometer in 76 subjects recruited from the patient population and staff of a primary-care center. After both devices were placed on the left arm or finger of the left hand, three BP readings were obtained with each device in alternating fashion, thereby according random assignment. The mean for all measurements was 119. Read More

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December 1991

Gentamicin pharmacokinetics in postpartum women with endomyometritis.

DICP 1991 Dec;25(12):1306-9

College of Pharmacy, Oregon State University, Oregon Health Sciences University Hospital, Portland.

The pharmacokinetics of gentamicin in postpartum women with endomyometritis were characterized and models for predicting patient pharmacokinetic parameters were developed using multiple regression analysis. Fifty-one women 13-34 years of age received gentamicin in combination with either ampicillin or clindamycin to treat endomyometritis. Forty-three women delivered by cesarean section and 8 women had vaginal deliveries. Read More

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December 1991

Steady-state pharmacokinetics of hydroxychloroquine in rheumatoid arthritis patients.

DICP 1991 Dec;25(12):1302-5

College of Pharmacy, North Dakota State University, Fargo 58105.

Steady-state pharmacokinetics of hydroxychloroquine (HC) sulfate (Plaquenil) were studied in five volunteers with rheumatoid arthritis who had taken 6 mg/kg/d of the drug for at least six months. Blood samples were drawn at 0, 1, 2, 4, 6, 8, 12, and 24 hours following an oral dose. Both whole blood and plasma were assayed by an HPLC method for HC and its metabolites desethylhydroxychloroquine, desethylchloroquine, and didesethylchloroquine. Read More

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December 1991