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Ann Thorac Surg 2021 Jul 31. Epub 2021 Jul 31.

Department of Surgery, Duke University Medical Center.

In 1995, Dr. Martin Dalton published a recounting of his involvement with the first human lung transplant in the Annals of Thoracic Surgery. As recalled in that account, the first lung transplant took place in the summer of 1963 in the context of another historical event, the assassination of Medgar Evers. Read More

Ann Intern Med 2021 Aug 3:OC1. Epub 2021 Aug 3.

University of Alabama at Birmingham, Birmingham, Alabama (A.S.I.).

Ann Hepatol 2021 Jul 28:100523. Epub 2021 Jul 28.

Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde" and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico. Electronic address:

Ann Emerg Med 2021 Aug;78(2):310-312

Department of Emergency Medicine, MedStar Washington Hospital Center.

J Craniofac Surg 2021 Jul 23. Epub 2021 Jul 23.

Houston, TX.

J Craniofac Surg 2021 Jul 23. Epub 2021 Jul 23.

Division of Plastic Surgery, Baylor College of Medicine, Houston, TX.

Ann Intern Med 2021 07 27. Epub 2021 Jul 27.

Guangdong Provincial People's Hospital, Guangzhou, China (H.D., M.L., Y.W., S.Z., H.Z.).

Ann Intern Med 2021 07 27. Epub 2021 Jul 27.

University of Texas, Austin, Texas (G.E.F.).

Ann Intern Med 2021 Jul;174(7):OC1

University of Alabama at Birmingham, Birmingham, Alabama (A.S.I.).

J Craniofac Surg 2021 Jul 20. Epub 2021 Jul 20.

Houston, Texas.

J Craniofac Surg 2021 Jul 20. Epub 2021 Jul 20.

Houston, Texas.

Ann Surg Oncol 2021 Jul 21. Epub 2021 Jul 21.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Background: The scientific rigor of the abstracts presented at the American Society of Breast Surgeons (ASBrS) annual meeting has not been recently evaluated. In this study, we sought to determine the rate at which abstracts presented at the 2017 and 2018 ASBrS meetings were published in peer-reviewed journals, and compared the rates with breast abstracts presented at the 2018 Society of Surgical Oncology (SSO) meeting.

Methods: Abstracts from the 2017 and 2018 ASBrS and 2018 SSO conferences were searched in PubMed for published manuscripts using the abstract title and/or first or last author. Read More

J Hist Neurosci 2021 Jul 20:1-11. Epub 2021 Jul 20.

Department of Neurology, Korea University Anam-hospital, Seoul, Republic of Korea.

King Yeongjo, the 21st king of Joseon (18th Century Korea), reigned during the prime years of the dynasty and was its oldest king. Despite his many accomplishments, debate surrounds his reputed display of the symptoms of dementia during the last years of his life.  The King showed signs of dementia after 40 years of his regency in 1762 at the age of 69 years, including disorientation, cognitive impairment, amnestic disorder and so on. Read More

Ann Intern Med 2021 Jul;174(7):HO2-HO3

University of Bern, Bern, and University Clinic for Visceral Medicine and Surgery, Inselspital, Switzerland (J.B.).

Ann Intern Med 2021 Jul;174(7):ED7

Ann Intern Med 2021 Jul;174(7):HO7

From Michigan Medicine and VA Ann Arbor Healthcare System, Ann Arbor, Michigan (D.H.W, J.A., M.L.).

Ann Intern Med 2021 Jul;174(7):CG1

Thomas Jefferson University, Philadelphia, Pennsylvania (G.J.M., H.H.W.).

Ann Transl Med 2021 Jun;9(12):1041

Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT, USA.

Immunotherapy has broadened the therapeutic scope and response for many cancer patients with drugs that are generally of higher efficacy and less toxicity than prior therapies. Multiple classes of immunotherapies such as targeted antibodies and immune checkpoint inhibitors (ICI), cell-based immunotherapies, immunomodulators, vaccines, and oncolytic viruses have been developed to help the immune system target and destroy malignant tumors. ICI targeting programmed cell death protein-1 (PD-1) or its ligand (PD-L1) are among the most effective immunotherapy agents and are a major focus of current investigations. Read More

Ann Transl Med 2021 Jun;9(12):1038

Division of Hematology, Oncology and Blood and Marrow Transplantation and the Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Prognosis of metastatic melanoma has undergone substantial improvement with the discovery of checkpoint inhibitors. Immunotherapies and targeted therapies have improved the median overall survival (OS) of metastatic melanoma from 6 months to more than 3 years. However, still about half of the patients die due to uncontrolled disease. Read More

Ann Transl Med 2021 Jun;9(12):1033

Division of Rheumatology, University of Washington, Seattle, WA, USA.

Background: Patients with pre-existing autoimmune disease (AD) have been largely excluded from clinical trials of immune checkpoint inhibitors (ICI), so data on safety of ICIs among patients with pre-existing AD are relatively limited. There is a need for deeper understanding of the type and management of complications from ICI in patients with pre-existing AD. We sought to investigate the safety of ICIs in patients with pre-existing ADs as well as factors associated with AD flare. Read More

Ann Transl Med 2021 Jun;9(12):1032

Clinical Professor, Department of Internal Medicine, Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Iowa, Iowa City, IA, USA. (Email:

Ann Transl Med 2021 Jun;9(12):1030

Division of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou, China.

Ann Transl Med 2021 Jun;9(12):988

Department of Gastroenterology, Daping Hospital of Third Military Medical University, Chongqing, China.

Background: Data on patients with coronavirus disease 2019 (COVID-19) who have pre-existing cerebrovascular disease (CVD) are scarce. This study set out to describe the clinical course and outcomes of these patients.

Methods: This single-center retrospective study was performed at Huoshenshan Hospital in Wuhan, China. Read More

Ann Transl Med 2021 May;9(9):823

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Artificial intelligence (AI) is a growing field of research that is emerging as a promising adjunct to assist physicians in detection and management of patients with cancer. F-FDG PET imaging helps physicians in detection and management of patients with cancer. In this study we discuss the possible applications of AI in F-FDG PET imaging based on the published studies. Read More

Ann Transl Med 2021 May;9(9):821

The Russell H. Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine and Molecular Imaging, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Recent years have witnessed a rapidly expanding use of artificial intelligence and machine learning in medical imaging. Generative adversarial networks (GANs) are techniques to synthesize images based on artificial neural networks and deep learning. In addition to the flexibility and versatility inherent in deep learning on which the GANs are based, the potential problem-solving ability of the GANs has attracted attention and is being vigorously studied in the medical and molecular imaging fields. Read More

Ann Transl Med 2021 May;9(9):820

Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Artificial intelligence (AI) has been widely applied to medical imaging. The use of AI for emission computed tomography, particularly single-photon emission computed tomography (SPECT) emerged nearly 30 years ago but has been accelerated in recent years due to the development of AI technology. In this review, we will describe and discuss the progress of AI technology in SPECT imaging. Read More

Ann Transl Med 2021 May;9(9):817

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (Email:

Ann Transl Med 2021 May;9(9):816

State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

Ann Transl Med 2021 May;9(9):812

Department of Critical Care Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.

It is increasingly important to accurately and comprehensively estimate the effects of particular clinical treatments. Although randomization is the current gold standard, randomized controlled trials (RCTs) are often limited in practice due to ethical and cost issues. Observational studies have also attracted a great deal of attention as, quite often, large historical datasets are available for these kinds of studies. Read More

Ann Transl Med 2021 May;9(9):790

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Endometriosis is a debilitating gynecological condition that manifests many common malignant features, including migration and invasion. Hypoxia is a hallmark of endometriosis, characterized by endometrial cell metastasis via epithelial-mesenchymal transition (EMT). The long noncoding RNA (lncRNA) UBOX antisense RNA 1 (UBOX5-AS1) has been shown to be upregulated in ovarian endometriosis. Read More