3,014 results match your criteria Annals Of Nuclear Medicine[Journal]


Brain partial volume correction with point spreading function reconstruction in high-resolution digital PET: comparison with an MR-based method in FDG imaging.

Ann Nucl Med 2022 May 26. Epub 2022 May 26.

Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, 6-10 Senshu-Kubota Machi, Akita, 010-0874, Japan.

Objective: In quantitative positron emission tomography (PET) of the brain, partial volume effect due mainly to the finite spatial resolution of the PET scanner (> 3 mm full width at half maximum [FWHM]) is a primary source of error in the measurement of tracer uptake, especially in small structures such as the cerebral cortex (typically < 3 mm thickness). The aim of this study was to evaluate the partial volume correction (PVC) performance of point spread function-incorporated reconstruction (PSF reconstruction) in combination with the latest digital PET scanner. This evaluation was performed through direct comparisons with magnetic resonance imaging (MR)-based PVC (used as a reference method) in a human brain study. Read More

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[Ga]Ga-NODAGAZOL uptake in atherosclerotic plaques correlates with the cardiovascular risk profile of patients.

Ann Nucl Med 2022 May 25. Epub 2022 May 25.

Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa.

Objectives: This study aimed to determine the correlation of [Ga]Ga-NODAGA uptake in atherosclerotic plaques and the cardiovascular risk profile of patients imaged with positron emission tomography (PET), wherein quantification of uptake was determined by atherosclerotic plaque maximum target-to-background ratio (TBRmax). We also correlated uptake with a history of cardiovascular events.

Methods: We included patients who underwent PET/CT imaging post-injection of [Ga] Ga-NODAGA. Read More

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Physiological background parenchymal uptake of F-FDG in normal breast tissues using dedicated breast PET: correlation with mammographic breast composition, menopausal status, and menstrual cycle.

Ann Nucl Med 2022 May 24. Epub 2022 May 24.

Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Objective: This study aimed to quantitatively evaluate the effects of age, mammographic density, menopausal status, and menstrual cycle on background parenchymal uptake (BPU) using ring-shaped dedicated breast positron emission tomography (dbPET).

Methods: This study included 186 adult women who underwent mammography and dbPET on the same day and had no abnormalities classified as Breast Imaging Reporting and Data System (BI-RADS) category 1 on both examinations. The volume of interest (VOI) was placed in the glandular tissue of both breasts, and the maximum standardized uptake value (SUV), mean standardized uptake value (SUV), and metabolic breast volume (MBV) were measured as indicators of BPU. Read More

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Clinical value of F-FDG PET/CT in IgG4-related disease.

Ann Nucl Med 2022 May 23. Epub 2022 May 23.

Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095th Jiefang Avenue, Wuhan, 430022, Hubei, China.

Objective: To investigate the clinical value of F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (F-FDG PET/CT) in IgG4-related disease (IgG4-RD).

Methods: Seventy two patients diagnosed with IgG4-RD who underwent PET/CT were included. Correlations between clinical variables and PET/CT findings were analyzed by Spearman's correlation test. Read More

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Ga-DOTA-FAPI-04 PET/CT imaging in radioiodine-refractory differentiated thyroid cancer (RR-DTC) patients.

Ann Nucl Med 2022 May 12. Epub 2022 May 12.

Department of Nuclear Medicine, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian Province, China.

Objective: This study aimed to assess the potential of Ga-DOTA-FAPI-04 PET/CT for the detection of the radioiodine-refractory differentiated thyroid cancer (RR-DTC) lesions.

Methods: We analyzed the Ga-DOTA-FAPI-04 PET/CT imaging data of 24 RR-DTC patients (7 men and 17 women; 49.6 ± 10. Read More

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Impact of patient body habitus on image quality and quantitative value in bone SPECT/CT.

Ann Nucl Med 2022 Jun 11;36(6):586-595. Epub 2022 May 11.

Department of Nuclear Medicine, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Objective: The first edition of guidelines for standardization of bone single photon emission computed tomography (SPECT) imaging was published in 2017, and the optimization and standardization are widely promoted. To the purpose, clarification of the factors related to image quality and quantitative values and their influence are required. The present study aimed to clarify and optimize the influence of patient body habitus on image quality and quantitative values in bone SPECT/CT. Read More

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Physiologically intense FDG uptake of distal spinal cord on total-body PET/CT.

Ann Nucl Med 2022 May 10. Epub 2022 May 10.

PET Center, Department of Nuclear Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, 510080, China.

Objective: Physiologically mild-to-moderate FDG uptake of the spinal cord was reported. However, we noticed intense FDG uptake of distal spinal cord in several patients without definite spinal cord lesions on total-body PET/CT. Thus, this study aimed to investigate the frequency, pattern, intensity, and associations of FDG uptake in such cases on total-body PET/CT. Read More

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F18-FDG PET/CT imaging early predicts pathologic complete response to induction chemoimmunotherapy of locally advanced head and neck cancer: preliminary single-center analysis of the checkrad-cd8 trial.

Ann Nucl Med 2022 May 10. Epub 2022 May 10.

Department of Radiation Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Bayern, Germany.

Aim: In the CheckRad-CD8 trial patients with locally advanced head and neck squamous cell cancer are treated with a single cycle of induction chemo-immunotherapy (ICIT). Patients with pathological complete response (pCR) in the re-biopsy enter radioimmunotherapy. Our goal was to study the value of F-18-FDG PET/CT in the prediction of pCR after induction therapy. Read More

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Thyroid function after diagnostic I-metaiodobenzylguanidine in children with neuroblastic tumors.

Ann Nucl Med 2022 Jun 2;36(6):579-585. Epub 2022 May 2.

Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, PO Box 85090, 3508 AB, Utrecht, The Netherlands.

Background: Metaiodobenzylguanidine (MIBG) labeled with radioisotopes can be used for diagnostics I) and treatment (I) in patients with neuroblastic tumors. Thyroid dysfunction has been reported in 52% of neuroblastoma (NBL) survivors after I-MIBG, despite thyroid protection. Diagnostic I-MIBG is not considered to be hazardous for thyroid function; however, this has never been investigated. Read More

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Diagnosis of prosthetic joint infection at the hip using the standard uptake value of three-phase 99mTc-hydroxymethylene diphosphonate SPECT/CT.

Ann Nucl Med 2022 Apr 28. Epub 2022 Apr 28.

Department of Diagnostic Radiology, Sapporo Medical University, South 1 West 17, Chuo-Ku, Sapporo, 060-8556, Japan.

Purpose: To retrospectively investigate whether the standard uptake value (SUV) of 99mTc-bone single-photon emission computed tomography (SPECT)/CT could be useful for predicting prosthetic joint infection (PJI) at the hip.

Patients And Methods: We analyzed the cases of 37 patients with a suspected PJI at the hip who underwent 99mTc-bone SPECT/CT and surgical intervention with pathological and bacterial examinations. We divided the cases into those with and those without a causative bacterium detected in a surgical specimen, i. Read More

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Tc-PSMA targeted robot-assisted radioguided surgery during radical prostatectomy and extended lymph node dissection of prostate cancer patients.

Ann Nucl Med 2022 Apr 15. Epub 2022 Apr 15.

Health Sciences University, Istanbul Research and Training Hospital, Clinic of Nuclear Medicine, Istanbul, Turkey.

Objective: The feasibility of tracer production of technetium (Tc)-prostate-specific membrane antigen (PSMA)-I&S sterile cold kit, imaging with single photon emission tomography/computed tomography (SPECT/CT), and Tc-PSMA-radioguided robot-assisted laparoscopic radical prostatectomy (Tc-PSMA-RG-RALRP) technique for lymph node (LN) dissection of primary prostate cancer (PCa) patients were evaluated prospectively.

Methods: Fifteen primary PCa patients with intermediate- or high-risk score according to D'Amico risk stratification who had PSMA receptor affinity with Ga-68 PSMA-11 PET/CT were enrolled. After Tc-PSMA-I&S injection and SPECT/CT imaging, Tc-PSMA-RG-RALRP with DaVinci XI robotic platform and laparoscopic gamma probe were performed. Read More

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The role of Ga PSMA PET/CT imaging in Lu PSMA treatment planning in metastatic castration-resistant prostate cancer.

Ann Nucl Med 2022 Jun 9;36(6):562-569. Epub 2022 Apr 9.

Department of Nuclear Medicine, Suleyman Demirel University Faculty of Medicine, Isparta, 32260, Turkey.

Objective: Lutetium-177 (Lu) prostate-specific membrane antigen (Lu PSMA) is a novel targeted treatment for patients with metastatic castration-resistant prostate cancer (CRPC). The purpose of the study was to determine the molecular volumetric Gallium-68 (Ga) PSMA PET/CT parameters that can predict patients who will respond to treatment.

Methods: These single-center retrospective data were obtained from metastatic CRPC patients receiving intravenous 6. Read More

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Application of F-FDG brain PET for survival prediction in a rat model of hanging-induced hypoxic brain injury.

Ann Nucl Med 2022 Jun 5;36(6):570-578. Epub 2022 Apr 5.

Department of Nuclear Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.

Background: Accurate prediction of survival outcomes after hanging is a crucial and challenging issue in comatose survivors. In this preclinical study, we evaluated the potential utility of using brain glucose metabolism as measured by fluorine-18-fluorodeoxyglucose (F-FDG) positron emission tomography (PET) for survival prediction in a rat model of hanging-induced hypoxic brain injury (HBI).

Methods: HBI was induced by mechanical hanging using Sprague Dawley rats. Read More

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An evaluation of the response to neoadjuvant chemotherapy for osteosarcoma of extremities: PERCIST versus RECIST 1.1 criteria after long-term follow-up.

Ann Nucl Med 2022 Jun 5;36(6):553-561. Epub 2022 Apr 5.

Musculoskeletal Tumor Center, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, China.

Objective: The aim of this study was to compare the recent Positron emission tomography (PET) Response Criteria in Solid Tumors (PERCIST) and Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria for evaluating the response of osteosarcoma to neoadjuvant chemotherapy of the extremities.

Methods: We retrospectively reviewed patients with osteosarcoma of the extremities who received neoadjuvant chemotherapy and then surgical resection at Peking University People's Hospital. Read More

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Beads phantom for evaluating heterogeneity of SUV on F-FDG PET images.

Ann Nucl Med 2022 May 4;36(5):495-503. Epub 2022 Apr 4.

Department of Radiology, Kanazawa Medical University Hospital, Uchinada, Kahoku, Japan.

Purpose: This study aimed to develop a dedicated phantom using acrylic beads for texture analysis and to represent heterogeneous F-fluorodeoxyglucose (FDG) distributions in various acquisition periods.

Methods: Images of acrylic spherical beads with or without diameters of 5- and 10-mm representing heterogeneous and homogeneous F-FDG distribution in phantoms, respectively, were collected for 20 min in list mode. Phantom data were reconstructed using three-dimensional ordered subset expectation maximization with attenuation and scatter corrections, and the time-of-flight algorithm. Read More

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Time point-independent tumor positivity of Ga-PSMA-PET/CT pre- and post-biopsy in high-risk prostate cancer.

Ann Nucl Med 2022 Jun 1;36(6):523-532. Epub 2022 Apr 1.

Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, China.

Objective: Prostate-specific membrane antigen (PSMA)-PET/CT imaging has gained increasing clinical importance for the detection and staging of high-risk primary prostate cancer (PCa). However, it is unclear whether the routine practice of prostate biopsy obscures the image finding of PSMA-PET/CT. This study aimed to compare the tumor positivity rate of PSMA-PET/CT performed pre- (PSMA-PET/CT) and post-biopsy (PSMA-PET/CT) in high-risk PCa patients. Read More

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Comparison of transient and permanent LAD ligation in mice using 18F-FDG PET imaging.

Ann Nucl Med 2022 Jun 30;36(6):533-543. Epub 2022 Mar 30.

Department of Nuclear Medicine, Ludwig-Maximilians-University Munich, University Hospital, Marchioninistr, 15, 81377, Munich, Germany.

Objective: Animal models for myocardial injuries represent important cornerstones in cardiovascular research to monitor the pathological processes and therapeutic approaches. We investigated the association of 18F-FDG derived left ventricular metabolic volume (LVMV), defect area and cardiac function in mice after permanent or transient ligation of the left anterior descending artery (LAD).

Methods: Serial non-invasive ECG-gated 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (18F-FDG PET) after permanent or transient LAD ligation enabled a longitudinal in vivo correlation of 18F-FDG derived left ventricular metabolic volume to functional parameters and myocardial defect. Read More

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Efficacy of myocardial washout of Tc-MIBI/Tetrofosmin for the evaluation of inflammation in patients with cardiac sarcoidosis: comparison with F-fluorodeoxyglucose positron emission tomography findings.

Ann Nucl Med 2022 Jun 18;36(6):544-552. Epub 2022 Mar 18.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Objective: Both myocardial perfusion scintigraphy and F-fluorodeoxyglucose positron emission tomography (FDG PET) are useful for the diagnosis of cardiac sarcoidosis (CS). However, the association between the washout of Tc-labeled tracer and FDG PET has not been established. This study aimed to evaluate the association between the washout of Tc-labeled tracer and FDG PET findings in patients with CS. Read More

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18F-FDG PET/CT as predictive and prognostic factor in esophageal cancer treated with combined modality treatment.

Ann Nucl Med 2022 May 11;36(5):450-459. Epub 2022 Mar 11.

Unit of Medical Physics, University Hospital "Maggiore Della Carità", corso Mazzini 18, 28100, Novara, Italy.

Purpose: [18F] fluorodeoxyglucose positron emission tomography/computed tomography ([18F] FDG-PET/CT) is used for diagnosis, staging, response assessment and prognosis prediction in different tumors, but its role in esophageal cancer is still debated. The aim of this study was to evaluate the role of semiquantitative baseline PET parameters as possible prognostic and predictive factors in a series of esophageal carcinomas treated with combined modalities.

Methods: 43 patients with esophageal carcinoma were treated with chemoradiotherapy (CRT) followed by surgery in 20 cases and underwent pre-treatment 18F-FDG-PET/CT. Read More

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Therapy-induced bone changes in oncology imaging with F-sodium fluoride (NaF) PET-CT.

Ann Nucl Med 2022 Apr 26;36(4):329-339. Epub 2022 Feb 26.

Department of Nuclear Medicine, Jaber Al-Ahmad Molecular Imaging Center, Khaitan, Kuwait.

F-Sodium fluoride (F-NaF) is a PET tracer that is mostly used in the evaluation of bone metastasis in oncology cases. Recently, F-NaF PET/CT is gaining wide popularity owing to its higher sensitivity over the other conventional bone tracer with higher and rapid single-pass extraction, negligible plasma protein binding, rapid blood, and renal clearance. In the era of constant evolution of cancer therapy regimens, considerable bone health impact is seen in the form of avascular necrosis, insufficiency fractures, among others. Read More

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Role of nanoparticles in transarterial radioembolization with glass microspheres.

Ann Nucl Med 2022 May 23;36(5):479-487. Epub 2022 Feb 23.

Division of Radiation Protection and Safety Control, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.

Objective: Transarterial Radioembolization (TARE) with Y-loaded glass microspheres is a locoregional treatment option for Hepatocellular Carcinoma (HCC). Post-treatment Y bremsstrahlung imaging using Single-Photon Emission Tomography (SPECT) is currently a gold-standard imaging modality for quantifying the delivered dose. However, the nature of bremsstrahlung photons causes difficulty for dose estimation using SPECT imaging. Read More

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Ventilation/perfusion imaging predicts response to balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension.

Ann Nucl Med 2022 Jun 22;36(6):515-522. Epub 2022 Feb 22.

Department of Nuclear Medicine, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences, 167 Beilishi Road, Beijing, 100037, China.

Objects: Although balloon pulmonary angioplasty (BPA) has emerged as an alternative treatment option for chronic thromboembolic pulmonary hypertension (CTEPH), it is followed in some patients by residual PH. We studied the efficacy of BPA on pulmonary blood flow and the predictive value of ventilation/perfusion (V/Q) scanning.

Methods: We retrospectively reviewed the clinical database, which included patients diagnosed with CTEPH who had received BPA. Read More

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Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels.

Ann Nucl Med 2022 Jun 22;36(6):507-514. Epub 2022 Feb 22.

Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.

Purpose: To estimate the interobserver agreement of the Carimas software package (SP) on global, regional, and segmental levels for the most widely used myocardial perfusion PET tracer-Rb-82.

Materials And Methods: Rest and stress Rb-82 PET scans of 48 patients with suspected or known coronary artery disease (CAD) were analyzed in four centers using the Carimas SP. We considered values to agree if they simultaneously had an intraclass correlation coefficient (ICC) > 0. Read More

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Influence of antidepressant use on I-MIBG heart and lung uptakes in the diagnosis of Lewy body disease.

Ann Nucl Med 2022 May 19;36(5):488-494. Epub 2022 Feb 19.

Department of Nuclear Medicine, Graduate School of Medicine, The International University of Health and Welfare, Narita, Japan.

Objective: The clinical significance of decreased physiological lung uptake of I-metaiodobenzylguanidine (MIBG) has not been well investigated. This study aimed to elucidate the association between a decrease in lung MIBG uptake with antidepressant intake and the myocardial MIBG uptake in patients who were clinically diagnosed with Lewy body disease (LBD) and patients who were diagnosed as not having LBD.

Methods: We retrospectively reviewed the heart and lung uptakes on 167 consecutive MIBG scans, antidepressant status, and clinical diagnosis of LBD. Read More

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Deep learning-based detection of parathyroid adenoma by Tc-MIBI scintigraphy in patients with primary hyperparathyroidism.

Ann Nucl Med 2022 May 18;36(5):468-478. Epub 2022 Feb 18.

Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, 1-4-3, Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.

Objective: It is important to detect parathyroid adenomas by parathyroid scintigraphy with 99m-technetium sestamibi (Tc-MIBI) before surgery. This study aimed to develop and validate deep learning (DL)-based models to detect parathyroid adenoma in patients with primary hyperparathyroidism, from parathyroid scintigrams with Tc-MIBI.

Methods: DL-based models for detecting parathyroid adenoma in early- and late-phase parathyroid scintigrams were, respectively, developed and evaluated. Read More

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Prediction of cardiac events following concurrent chemoradiation therapy for non-small-cell lung cancer using FDG PET.

Ann Nucl Med 2022 May 17;36(5):439-449. Epub 2022 Feb 17.

Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, 322, Seoyang-ro, Hwasun-gun, Jeonnam, 58128, Republic of Korea.

Objective: No imaging biomarkers are available for the prediction of cardiac events following concurrent chemoradiation therapy (CCRT) for non-small-cell lung cancer (NSCLC). We evaluated whether F-18 fluorodeoxyglucose positron emission tomography (FDG PET) early after CCRT, in addition to cardiac dosimetry, could predict late cardiac events in NSCLC.

Methods: We retrospectively enrolled 133 consecutive patients with locally advanced, unresectable stage III NSCLC, who underwent FDG PET early after CCRT and survived at least 6 months. Read More

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Voxel-based analysis of age and gender effects on striatal [I] FP-CIT binding in healthy Japanese adults.

Ann Nucl Med 2022 May 16;36(5):460-467. Epub 2022 Feb 16.

Department of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.

Objective: Although previous studies have investigated age and gender effects on striatal subregional dopamine transporter (DaT) binding, these studies were mostly based on a conventional regions of interest-based analysis. Here, we investigated age and gender effects on striatal DaT binding at the voxel level, using a multicenter database of [()I] N-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane ([()I] FP-CIT)-single photon emission computed tomography (SPECT) scans in 256 healthy Japanese adults.

Methods: We used the Southampton method to calculate the specific binding ratios (SBRs) of each subject's striatum and then converted the [I] FP-CIT SPECT images to quantitative SBRs images. Read More

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Initial evaluation of a new maximum-likelihood attenuation correction factor-based attenuation correction for time-of-flight brain PET.

Ann Nucl Med 2022 Apr 9;36(4):420-426. Epub 2022 Feb 9.

Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University, Osakasayama, Japan.

Aim: The aim of this study was to evaluate an image reconstruction algorithm, including a new maximum-likelihood attenuation correction factor (ML-ACF) for time of flight (TOF) brain positron emission tomography (PET).

Methods: The implemented algorithm combines an ML-ACF method that simultaneously estimates both the emission image and attenuation sinogram from TOF emission data, and a scaling method based on anatomical features. To evaluate the algorithm's quantitative accuracy, three-dimensional brain phantom images were acquired and soft-tissue attenuation coefficients and emission values were analyzed. Read More

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