Ann Neurol 2022 May 22. Epub 2022 May 22.
Laboratory of Neurogenetics, Molecular Genetics Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Objective: The aim of the current study is to understand why some individuals avoid developing Parkinson's disease (PD) in spite of being at relatively high genetic risk, using the largest datasets of individual-level genetic data available.
Methods: We calculated polygenic risk score to identify controls and matched PD cases with the highest burden of genetic risk for PD in the discovery cohort (IPDGC, 7,204 PD cases and 9,412 controls) and validation cohorts (COURAGE-PD, 8,968 cases and 7,598 controls; UKBB, 2,639 PD cases and 14,301 controls; AMP-PD, 2,248 cases and 2,817 controls). A genome-wide association study meta-analysis was performed on these individuals to understand genetic variation associated with resistance to disease. Read More