847 results match your criteria Annals Of Intensive Care[Journal]


Journal club in an ICU: rate and factors associated with practice-changing articles. Analysis of 1712 articles read over a 13-year period (2007-2019).

Ann Intensive Care 2020 Jun 1;10(1):70. Epub 2020 Jun 1.

Service de Réanimation Polyvalente et Unité de Surveillance Continue, Centre Hospitalier Victor Dupouy, 69, rue du Lieutenant-Colonel Prud'hon, 95100, Argenteuil, France.

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http://dx.doi.org/10.1186/s13613-020-00688-2DOI Listing

Organizational factors associated with adherence to low tidal volume ventilation: a secondary analysis of the CHECKLIST-ICU database.

Ann Intensive Care 2020 Jun 1;10(1):68. Epub 2020 Jun 1.

Department of Critical Care Medicine, Hospital Israelita Albert Einstein, Albert Einstein Avenue, 700, São Paulo, Brazil.

Background: Survival benefit from low tidal volume (V) ventilation (LTVV) has been demonstrated for patients with acute respiratory distress syndrome (ARDS), and patients not having ARDS could also benefit from this strategy. Organizational factors may play a role on adherence to LTVV. The present study aimed to identify organizational factors with an independent association with adherence to LTVV. Read More

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http://dx.doi.org/10.1186/s13613-020-00687-3DOI Listing

Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children.

Ann Intensive Care 2020 Jun 1;10(1):69. Epub 2020 Jun 1.

Pediatric Intensive Care Unit, Necker-Enfants-Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris University, EA7323, 75006, Paris, France.

Background: A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. This is a case series performed at 4 academic tertiary care centers in Paris of all the children admitted to the pediatric intensive care unit (PICU) with shock, fever and suspected SARS-CoV-2 infection between April 15th and April 27th, 2020.

Results: 20 critically ill children admitted for shock had an acute myocarditis (left ventricular ejection fraction, 35% (25-55); troponin, 269 ng/mL (31-4607)), and arterial hypotension with mainly vasoplegic clinical presentation. Read More

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http://dx.doi.org/10.1186/s13613-020-00690-8DOI Listing

COVID-19-associated invasive pulmonary aspergillosis.

Ann Intensive Care 2020 Jun 1;10(1):71. Epub 2020 Jun 1.

Dept. of Intensive Care Medicine, Ziekenhuisnetwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, 2060, Antwerp, Belgium.

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http://dx.doi.org/10.1186/s13613-020-00686-4DOI Listing

Correction to: Early sepsis markers in patients admitted to intensive care unit with moderate‑to‑severe diabetic ketoacidosis.

Ann Intensive Care 2020 Jun 2;10(1):72. Epub 2020 Jun 2.

Medical-Surgical Intensive Care Unit, Avicenne University Hospital, AP-HP, Paris 13 University, Sorbonne Paris Cité, 125 rue Stalingrad, 93000, Bobigny, France.

An amendment to this paper has been published and can be accessed via the original article. Read More

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http://dx.doi.org/10.1186/s13613-020-00691-7DOI Listing

Recruitment pattern of the diaphragm and extradiaphragmatic inspiratory muscles in response to different levels of pressure support.

Ann Intensive Care 2020 May 29;10(1):67. Epub 2020 May 29.

Department of Intensive Care Medicine, Amsterdam UMC, Location VUmc, Postbox 7057, 1007 MB, Amsterdam, The Netherlands.

Background: Inappropriate ventilator assist plays an important role in the development of diaphragm dysfunction. Ventilator under-assist may lead to muscle injury, while over-assist may result in muscle atrophy. This provides a good rationale to monitor respiratory drive in ventilated patients. Read More

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http://dx.doi.org/10.1186/s13613-020-00684-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256918PMC

Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA).

Ann Intensive Care 2020 May 24;10(1):64. Epub 2020 May 24.

Department of Intensive Care Medicine, Ziekenhuis Netwerk Antwerpen, ZNA Stuivenberg, Antwerp, Belgium.

Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of fluid administration as drug diluent or to preserve catheter patency, i. Read More

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http://dx.doi.org/10.1186/s13613-020-00679-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245999PMC

The end-expiratory occlusion test for detecting preload responsiveness: a systematic review and meta-analysis.

Ann Intensive Care 2020 May 24;10(1):65. Epub 2020 May 24.

Service de Médecine Intensive-Réanimation, Hôpital de Bicêtre, Hôpitaux Universitaires Paris-Saclay, 78, rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.

Background: We performed a systematic review and meta-analysis of studies assessing the end-expiratory occlusion test (EEXPO test)-induced changes in cardiac output (CO) measured by any haemodynamic monitoring device, as indicators of preload responsiveness.

Methods: MEDLINE, EMBASE and Cochrane Database were screened for original articles. Bivariate random-effects meta-analysis determined the Area under the Summary Receiver Operating Characteristic (AUSROC) curve of EEXPO test-induced changes in CO to detect preload responsiveness, as well as pooled sensitivity and specificity and the best diagnostic threshold. Read More

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http://dx.doi.org/10.1186/s13613-020-00682-8DOI Listing

Duration of prone position sessions: a prospective cohort study.

Ann Intensive Care 2020 May 24;10(1):66. Epub 2020 May 24.

Département de Médecine Intensive-Réanimation, GH Sud Ile-de-France, Hôpital de Melun, 270 avenue Marc Jacquet, 77000, Melun, France.

Background: Prone position (PP) is highly recommended in moderate-to-severe ARDS. However, the optimal duration of PP sessions remains unclear. We searched to evaluate the time required to obtain the maximum physiological effect, and to search for parameters related to patient survival in PP. Read More

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http://dx.doi.org/10.1186/s13613-020-00683-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245995PMC

Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study.

Ann Intensive Care 2020 May 24;10(1):62. Epub 2020 May 24.

Medical Intensive Care Unit, Angers University Hospital, Angers, France.

Background: No recommendation exists about the timing and setting for tracheal intubation and mechanical ventilation in septic shock.

Patients And Methods: This prospective multicenter observational study was conducted in 30 ICUs in France and Spain. All consecutive patients presenting with septic shock were eligible. Read More

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http://dx.doi.org/10.1186/s13613-020-00668-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245631PMC

Microvascular alterations in patients with SARS-COV-2 severe pneumonia.

Ann Intensive Care 2020 May 20;10(1):60. Epub 2020 May 20.

Anesthesia and Intensive Care Unit, Department of Biomedical Sciences and Public Health, Università Politecnica delle Marche, via Tronto 10/a, 60126, Ancona, Italy.

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http://dx.doi.org/10.1186/s13613-020-00680-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238400PMC

Nitric oxide inhalation as an interventional rescue therapy for COVID-19-induced acute respiratory distress syndrome.

Ann Intensive Care 2020 May 20;10(1):61. Epub 2020 May 20.

Faculty of Pharmacy & Pharmaceutical Science, Josai University, 1-1 Keyakidai, Sakado, Saitama, 350-0295, Japan.

COVID-19 is an emerging disease of public health concern. While there is no specific recommended treatment for COVID-19, nitric oxide has the potential to be of therapeutic value for managing acute respiratory distress syndrome in patients with COVID-19. However, inhaled nitric oxide has not yet been formally evaluated. Read More

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http://dx.doi.org/10.1186/s13613-020-00681-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238394PMC

Early sepsis markers in patients admitted to intensive care unit with moderate-to-severe diabetic ketoacidosis.

Ann Intensive Care 2020 May 19;10(1):58. Epub 2020 May 19.

Medical-Surgical Intensive Care Unit, Avicenne University Hospital, AP-HP, Paris 13 University, Sorbonne Paris Cité, 125 rue Stalingrad, 93000, Bobigny, France.

Background: Bacterial infections are frequent triggers for diabetic ketoacidosis. In this context, delayed antibiotic treatment is associated with increased morbidity and mortality. Unnecessary administration of antimicrobial therapy might however, also negatively impact the prognosis. Read More

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http://dx.doi.org/10.1186/s13613-020-00676-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237630PMC

Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study.

Ann Intensive Care 2020 May 13;10(1):56. Epub 2020 May 13.

Department of Intensive Care Medicine, Hospital Universitario Sagrat Cor, Viladomat 288, 08029, Barcelona, Spain.

Background: The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Sepsis incidence has risen in recent years and identification of outcomes is of considerable public importance. Read More

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http://dx.doi.org/10.1186/s13613-020-00672-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221097PMC

Beneficial effect modification on survival outcome of sepsis between ART-123 and polymyxin B‑immobilised haemoperfusion: a nationwide Japanese registry study.

Ann Intensive Care 2020 May 13;10(1):57. Epub 2020 May 13.

Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Background: Although recently published randomised controlled trials did not confirm significant positive effect of ART-123 or polymyxin B‑immobilised haemoperfusion (PMX-HP) on survival outcome, previous studies using a dataset of 3195 patients with sepsis registered at 42 intensive care units throughout Japan revealed significantly reduced mortality following these treatments. A study has suggested the efficacy of combination therapy with ART-123 and PMX-HP; however, it did not evaluate the effect modification between them. We hypothesised that coadministration of ART-123 and PMX-HP has a significant positive effect modification on survival outcome. Read More

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http://dx.doi.org/10.1186/s13613-020-00674-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221014PMC

Recruitability and effect of PEEP in SARS-Cov-2-associated acute respiratory distress syndrome.

Ann Intensive Care 2020 May 12;10(1):55. Epub 2020 May 12.

Département de Médecine Intensive-Réanimation, CHU d'Angers, Université d'Angers, 4 rue Larrey, 49933, Angers Cedex 9, France.

Background: A large proportion of patients with a SARS-Cov-2-associated respiratory failure develop an acute respiratory distress syndrome (ARDS). It has been recently suggested that SARS-Cov-2-associated ARDS may differ from usual non-SARS-Cov-2-associated ARDS by higher respiratory system compliance (C), lower potential for recruitment with positive end-expiratory pressure (PEEP) contrasting with severe shunt fraction. The purpose of the study was to systematically assess respiratory mechanics and recruitability in SARS-Cov-2-associated ARDS. Read More

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http://dx.doi.org/10.1186/s13613-020-00675-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215140PMC

Thenar oxygen saturation (StO) alterations during a spontaneous breathing trial predict extubation failure.

Ann Intensive Care 2020 May 11;10(1):54. Epub 2020 May 11.

Critical Care Department, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT), Parc Taulí, 1, 08208, Sabadell, Spain.

Background: Weaning from mechanical ventilation (MV) is a cardiovascular stress test. Monitoring the regional oxygenation status has shown promising results in predicting the tolerance to spontaneously breathe in the process of weaning from MV. Our aim was to determine whether changes in skeletal muscle oxygen saturation (StO) measured by near-infrared spectroscopy (NIRS) on the thenar eminence during a vascular occlusion test (VOT) can be used to predict extubation failure from mechanical ventilation. Read More

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http://dx.doi.org/10.1186/s13613-020-00670-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214564PMC

One-year survival in acute stroke patients requiring mechanical ventilation: a multicenter cohort study.

Ann Intensive Care 2020 May 7;10(1):53. Epub 2020 May 7.

Université de Paris, UMR 1137, IAME, Paris, France.

Background: Most prognostic studies in acute stroke patients requiring invasive mechanical ventilation are outdated and have limitations such as single-center retrospective designs. We aimed to study the association of ICU admission factors, including the reason for intubation, with 1-year survival of acute stroke patients requiring mechanical ventilation.

Methods: We conducted a secondary data use analysis of a prospective multicenter database (14 ICUs) between 1997 and 2016 on consecutive ICU stroke patients requiring mechanical ventilation at admission. Read More

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http://dx.doi.org/10.1186/s13613-020-00669-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205929PMC

Tracheostomy in patients with acute respiratory distress syndrome is not related to quality of life, symptoms of psychiatric disorders or return-to-work: the prospective DACAPO cohort study.

Ann Intensive Care 2020 May 6;10(1):52. Epub 2020 May 6.

Medical Sociology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.

Background: Acute respiratory distress syndrome (ARDS) is a life-threatening condition that often requires prolonged mechanical ventilation. Tracheostomy is a common procedure with some risks, on the other hand with potential advantages over orotracheal intubation in critically ill patients. This study investigated the association of tracheostomy with health-related quality of life (HRQoL), symptoms of psychiatric disorders and return-to-work of ARDS survivors. Read More

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http://dx.doi.org/10.1186/s13613-020-00671-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203349PMC

Urine NGAL as a biomarker for septic AKI: a critical appraisal of clinical utility-data from the observational FINNAKI study.

Ann Intensive Care 2020 Apr 28;10(1):51. Epub 2020 Apr 28.

Division of Intensive Care Medicine, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, PO Box 340, 00029 HUS, Helsinki, Finland.

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is released from kidney tubular cells under stress as well as from neutrophils during inflammation. It has been suggested as a biomarker for acute kidney injury (AKI) in critically ill patients with sepsis. To evaluate clinical usefulness of urine NGAL (uNGAL), we post-hoc applied recently introduced statistical methods to a sub-cohort of septic patients from the prospective observational Finnish Acute Kidney Injury (FINNAKI) study. Read More

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http://dx.doi.org/10.1186/s13613-020-00667-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188747PMC

Diagnosis and management of respiratory viruses in critically ill adult patients: an international survey of knowledge and practice among intensivists.

Ann Intensive Care 2020 Apr 28;10(1):50. Epub 2020 Apr 28.

Service de Médecine Intensive Réanimation, Hôpital Tenon, Sorbonne Université, Hôpitaux Universitaires de l'Est Parisien, Assistance Publique - Hôpitaux de Paris, Paris, France.

In this survey endorsed by the European Society of Intensive Care Medicine (ESICM), we aimed to describe the practice patterns of intensivists worldwide, regarding their diagnosis and management of respiratory viruses in lower respiratory tract infections. There were 229 respondents from 53 countries, mainly in Europe (78%). Our main findings are that a majority of intensivists (i) searched for respiratory viruses in case of severe community-acquired LRTI in adults, whatever the season and the medical history and clinical presentation; (ii) had access to large-panel respiratory mPCR; (iii) used them as first-line diagnostic test in routine practice; (iv) had some knowledge about the panel of the mPCR that they use, but markedly less about the cost. Read More

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http://dx.doi.org/10.1186/s13613-020-00660-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188742PMC

Systematic review and literature appraisal on methodology of conducting and reporting critical-care echocardiography studies: a report from the European Society of Intensive Care Medicine PRICES expert panel.

Ann Intensive Care 2020 Apr 25;10(1):49. Epub 2020 Apr 25.

Intensive Care Medicine Unit, Assistance Publique-Hôpitaux de Paris, University Hospital Ambroise Paré, 92100, Boulogne-Billancourt, France.

Background: The echocardiography working group of the European Society of Intensive Care Medicine recognized the need to provide structured guidance for future CCE research methodology and reporting based on a systematic appraisal of the current literature. Here is reported this systematic appraisal.

Methods: We conducted a systematic review, registered on the Prospero database. Read More

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http://dx.doi.org/10.1186/s13613-020-00662-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183522PMC

Bedside prediction of intradialytic hemodynamic instability in critically ill patients: the SOCRATE study.

Ann Intensive Care 2020 Apr 22;10(1):47. Epub 2020 Apr 22.

Service de Médecine Intensive Réanimation, AP-HP, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 184 rue du Faubourg Saint-Antoine, Paris, 75571 Cedex 12, France.

Background: Despite improvements in intermittent hemodialysis management, intradialytic hemodynamic instability (IHI) remains a common issue that could account for increased mortality and delayed renal recovery. However, predictive factors of IHI remain poorly explored. The objective of this study was to evaluate the relationship between baseline macrohemodynamic, tissue hypoperfusion parameters and IHI occurrence. Read More

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http://dx.doi.org/10.1186/s13613-020-00663-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176798PMC

Acute-on-chronic liver failure alters meropenem pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study.

Ann Intensive Care 2020 Apr 22;10(1):48. Epub 2020 Apr 22.

Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Background: Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing of antimicrobial therapy is of central importance to improve outcome. Liver failure may alter antibiotic drug concentrations via changes of drug distribution and elimination. Read More

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http://dx.doi.org/10.1186/s13613-020-00666-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176801PMC

Urinary [TIMP-2] × [IGFBP7] and serum procalcitonin to predict and assess the risk for short-term outcomes in septic and non-septic critically ill patients.

Ann Intensive Care 2020 Apr 21;10(1):46. Epub 2020 Apr 21.

International Renal Research Institute of Vicenza (IRRIV), San Bortolo Hospital, Vicenza, Italy.

Background: Biomarkers can play a critical role by facilitating diagnosis and stratification of disease, as well as assessment or prediction of disease severity. Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 product ([TIMP-2] × [IGFBP7]) predict the development and progression of AKI and recently procalcitonin (PCT), a widely used biomarker for sepsis diagnosis and management, has been associated with AKI occurrence in ICU patients. To assess combinations of [TIMP-2] × [IGFBP7] and PCT results for prediction and risk stratification of short-term outcomes in septic and non-septic patients, a retrospective cohort analysis of critically ill patients was performed in a multidisciplinary ICU. Read More

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http://dx.doi.org/10.1186/s13613-020-00665-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174532PMC

Factors associated with major adverse kidney events in patients who underwent veno-arterial extracorporeal membrane oxygenation.

Ann Intensive Care 2020 Apr 20;10(1):44. Epub 2020 Apr 20.

Medical and Infectious Intensive Care Unit, Bichat Claude Bernard University Hospital, AP-HP, 46 rue Henri Huchard, 75018, Paris, France.

Objective: To describe acute kidney injury (AKI) natural history and to identify predictors of major adverse kidney events (MAKE) within 1 year in patients supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

Design: Retrospective observational study.

Setting: Medical French intensive care unit between January 2014 and December 2016. Read More

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http://dx.doi.org/10.1186/s13613-020-00656-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167383PMC

Critically ill SARS-CoV-2-infected patients are not stratified as sepsis by the qSOFA.

Ann Intensive Care 2020 Apr 19;10(1):43. Epub 2020 Apr 19.

CHRU de Tours, Service de Médecine Intensive-Réanimation, CHRU Bretonneau, INSERM U1100, Centre d'Etude des Pathologies Respiratoires, Université de Tours, 2 Bd Tonnellé, 37044, Tours, France.

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http://dx.doi.org/10.1186/s13613-020-00664-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167215PMC

Therapeutic strategies for critically ill patients with COVID-19.

Ann Intensive Care 2020 Apr 20;10(1):45. Epub 2020 Apr 20.

Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.

Since the 2019 novel coronavirus disease (COVID-19) outbreak originated from Wuhan, Hubei Province, China, at the end of 2019, it has become a clinical threat to the general population worldwide. Among people infected with the novel coronavirus (2019-nCoV), the intensive management of the critically ill patients in intensive care unit (ICU) needs substantial medical resource. In the present article, we have summarized the promising drugs, adjunctive agents, respiratory supportive strategies, as well as circulation management, multiple organ function monitoring and appropriate nutritional strategies for the treatment of COVID-19 in the ICU based on the previous experience of treating other viral infections and influenza. Read More

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http://dx.doi.org/10.1186/s13613-020-00661-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167303PMC

SEA-MAKE score as a tool for predicting major adverse kidney events in critically ill patients with acute kidney injury: results from the SEA-AKI study.

Ann Intensive Care 2020 Apr 16;10(1):42. Epub 2020 Apr 16.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Bangkok, 10330, Thailand.

Background: Acute kidney injury (AKI) is a common problem in critically ill patients and associated with high rates of morbidity and mortality. Recently, Major Adverse Kidney Events (MAKE) were introduced as important kidney endpoints. If these endpoints can be predicted, then it may help the physicians to identify high-risk patients and provide the opportunity to have targeted preventive therapy. Read More

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http://dx.doi.org/10.1186/s13613-020-00657-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162998PMC

Characteristics of resuscitation, and association between use of dynamic tests of fluid responsiveness and outcomes in septic patients: results of a multicenter prospective cohort study in Argentina.

Ann Intensive Care 2020 Apr 15;10(1):40. Epub 2020 Apr 15.

Hospital Interzonal de Agudos San Martin de La Plata, La Plata, Buenos Aires, Argentina.

Background: Resuscitation of septic patients regarding goals, monitoring aspects and therapy is highly variable. Our aim was to characterize cardiovascular and fluid management of sepsis in Argentina, a low and middle-income country (LMIC). Furthermore, we sought to test whether the utilization of dynamic tests of fluid responsiveness, as a guide for fluid therapy after initial resuscitation in patients with persistent or recurrent hypoperfusion, was associated with decreased mortality. Read More

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http://dx.doi.org/10.1186/s13613-020-00659-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158970PMC

Diastolic shock index and clinical outcomes in patients with septic shock.

Ann Intensive Care 2020 Apr 16;10(1):41. Epub 2020 Apr 16.

Department of Intensive Care Medicine, Fundación Valle del Lili - Universidad ICESI, Av. Simón Bolívar Cra. 98, Cali, Colombia.

Background: Loss of vascular tone is a key pathophysiological feature of septic shock. Combination of gradual diastolic hypotension and tachycardia could reflect more serious vasodilatory conditions. We sought to evaluate the relationships between heart rate (HR) to diastolic arterial pressure (DAP) ratios and clinical outcomes during early phases of septic shock. Read More

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http://dx.doi.org/10.1186/s13613-020-00658-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160223PMC

Ocular microvascular changes in patients with sepsis: a prospective observational study.

Ann Intensive Care 2020 Apr 7;10(1):38. Epub 2020 Apr 7.

Department of Intensive Care Medicine, Lithuanian University of Health Sciences, Eiveniu str. 2, Kaunas, 50009, Lithuania.

Background: The aim of the study was to detect differences in the conjunctival microcirculation between septic patients and healthy subjects and to evaluate the course of conjunctival and retinal microvasculature in survivors and non-survivors over a 24-h period of time.

Methods: This single-center prospective observational study was performed in mixed ICU in a tertiary teaching hospital. We included patients with sepsis or septic shock within the first 24 h after ICU admission. Read More

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http://dx.doi.org/10.1186/s13613-020-00655-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138894PMC

Occurrence of pendelluft under pressure support ventilation in patients who failed a spontaneous breathing trial: an observational study.

Ann Intensive Care 2020 Apr 7;10(1):39. Epub 2020 Apr 7.

Department of Anesthesia and Intensive Care, San Gerardo Hospital, Monza, Italy.

Background: Pendelluft, the movement of gas within different lung regions, is present in animal models of assisted mechanical ventilation and associated with lung overstretching. Due to rebreathing of CO as compared to fresh gas, pendelluft might reduce ventilatory efficiency possibly exacerbating patient's respiratory workload during weaning. Our aim was to measure pendelluft by electrical impedance tomography (EIT) in patients who failed a spontaneous breathing trial (SBT). Read More

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http://dx.doi.org/10.1186/s13613-020-00654-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138895PMC

The experience of high-flow nasal cannula in hospitalized patients with 2019 novel coronavirus-infected pneumonia in two hospitals of Chongqing, China.

Ann Intensive Care 2020 Mar 30;10(1):37. Epub 2020 Mar 30.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Yuzhong District, Chongqing, 400016, People's Republic of China.

Background: The outbreak of a novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) is currently ongoing in China. Most of the critically ill patients received high-flow nasal cannula (HFNC) oxygen therapy. However, the experience of HFNC in this population is lacking. Read More

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http://dx.doi.org/10.1186/s13613-020-00653-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104710PMC

Prognostic impact of elevated lactate levels on mortality in critically ill patients with and without preadmission metformin treatment: a Danish registry-based cohort study.

Ann Intensive Care 2020 Mar 26;10(1):36. Epub 2020 Mar 26.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Background: Lactate is a robust prognostic marker for the outcome of critically ill patients. Several small studies reported that metformin users have higher lactate levels at ICU admission without a concomitant increase in mortality. However, this has not been investigated in a larger cohort. Read More

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http://dx.doi.org/10.1186/s13613-020-00652-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098407PMC

Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study.

Ann Intensive Care 2020 Mar 24;10(1):35. Epub 2020 Mar 24.

Department of Intensive Care, CHIREC Hospitals, Université Libre de Bruxelles, Brussels, Belgium.

Background: Ventilation/perfusion inequalities impair gas exchange in acute respiratory distress syndrome (ARDS). Although increased dead-space ventilation (V/V) has been described in ARDS, its mechanism is not clearly understood. We sought to evaluate the relationships between dynamic variations in V/V and extra-pulmonary microcirculatory blood flow detected at sublingual mucosa hypothesizing that an altered microcirculation, which is a generalized phenomenon during severe inflammatory conditions, could influence ventilation/perfusion mismatching manifested by increases in V/V fraction during early stages of ARDS. Read More

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http://dx.doi.org/10.1186/s13613-020-00651-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093634PMC

Adjunctive corticosteroids may be associated with better outcome for non-HIV Pneumocystis pneumonia with respiratory failure: a systemic review and meta-analysis of observational studies.

Ann Intensive Care 2020 Mar 20;10(1):34. Epub 2020 Mar 20.

Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing, China.

Background: Evidence supporting corticosteroids adjunctive treatment (CAT) for Pneumocystis jirovecii pneumonia (PCP) in non-HIV patients is highly controversial. We aimed to systematically review the literature and perform a meta-analysis of available data relating to the effect of CAT on mortality of PCP in non-HIV patients.

Methods: We searched Pubmed, Medline, Embase, and Cochrane database from 1989 through 2019. Read More

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http://dx.doi.org/10.1186/s13613-020-00649-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083987PMC

Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province.

Ann Intensive Care 2020 Mar 18;10(1):33. Epub 2020 Mar 18.

Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, No. 87, Dingjiaqiao Road, Gulou District, Nanjing, 210009, People's Republic of China.

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http://dx.doi.org/10.1186/s13613-020-00650-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080931PMC

Prescription of CRRT: a pathway to optimize therapy.

Ann Intensive Care 2020 Mar 6;10(1):32. Epub 2020 Mar 6.

Medical Affairs-Renal Care, Scientific Office, Baxter A.G., Burj Al Salam, PO Box 64332, Dubai, United Arab Emirates.

Severe acute kidney injury (AKI), especially when caused or accompanied by sepsis, is associated with prolonged hospitalization, progression to chronic kidney disease (CKD), financial burden, and high mortality rate. Continuous renal replacement therapy (CRRT) is a predominant form of renal replacement therapy (RRT) in the intensive care unit (ICU) due to its accurate volume control, steady acid-base and electrolyte correction, and achievement of hemodynamic stability. This manuscript reviews the different aspects of CRRT prescription in critically ill patients with severe AKI, sepsis, and multiorgan failure in ICU. Read More

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http://dx.doi.org/10.1186/s13613-020-0648-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060300PMC

Optimal mean airway pressure during high-frequency oscillatory ventilation in an experimental model of acute respiratory distress syndrome: EIT-based method.

Ann Intensive Care 2020 Mar 6;10(1):31. Epub 2020 Mar 6.

Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Jiangsu Province, Nanjing, 210009, China.

Background: High-frequency oscillatory ventilation (HFOV) may theoretically provide lung protective ventilation. The negative clinical results may be due to inadequate mean airway pressure (mPaw) settings in HFOV. Our objective was to evaluate the air distribution, ventilatory and hemodynamic effects of individual mPaw titration during HFOV in ARDS animal based on oxygenation and electrical impedance tomography (EIT). Read More

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http://dx.doi.org/10.1186/s13613-020-0647-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060304PMC

Comparison between watchful waiting strategy and early initiation of renal replacement therapy in the critically ill acute kidney injury population: an updated systematic review and meta-analysis.

Ann Intensive Care 2020 Mar 3;10(1):30. Epub 2020 Mar 3.

Department of Nephrology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: The optimal timing of renal replacement therapy (RRT) initiation is debatable. Many articles in this field enrolled trials not based on acute kidney injury. The safety of the watchful waiting strategy has not been fully discussed, and late RRT initiation criteria vary across studies. Read More

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http://dx.doi.org/10.1186/s13613-020-0641-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054512PMC

Correction to: Changes in the clinical presentation and outcomes of patients treated for severe malaria in a referral French university intensive care unit from 2004 to 2017.

Ann Intensive Care 2020 Mar 3;10(1):29. Epub 2020 Mar 3.

AP-HP, Bichat Hospital, Medical and Infectious Diseases ICU (MI2), University of Paris, IAME, INSERM U1137 (IAME), 75018, Paris, France.

After publication of the original article [1], we were notified that family names have been exchanged with the first names for all authors. Below the name are tagged correctly. Read More

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http://dx.doi.org/10.1186/s13613-020-0646-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054504PMC

Transpulmonary thermodilution detects rapid and reversible increases in lung water induced by positive end-expiratory pressure in acute respiratory distress syndrome.

Ann Intensive Care 2020 Mar 2;10(1):28. Epub 2020 Mar 2.

Service de médecine intensive - réanimation, Hôpitaux universitaires Paris-Saclay, Hôpital de Bicêtre, APHP, 78, rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.

Purpose: It has been suggested that, by recruiting lung regions and enlarging the distribution volume of the cold indicator, increasing the positive end-expiratory pressure (PEEP) may lead to an artefactual overestimation of extravascular lung water (EVLW) by transpulmonary thermodilution (TPTD).

Methods: In 60 ARDS patients, we measured EVLW (PiCCO2 device) at a PEEP level set to reach a plateau pressure of 30 cmHO (HighPEEP) and 15 and 45 min after decreasing PEEP to 5 cmHO (LowPEEP and LowPEEP, respectively). Then, we increased PEEP back to the baseline level (HighPEEP). Read More

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http://dx.doi.org/10.1186/s13613-020-0644-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052093PMC

Short- and long-term renal outcomes following severe rhabdomyolysis: a French multicenter retrospective study of 387 patients.

Ann Intensive Care 2020 Mar 2;10(1):27. Epub 2020 Mar 2.

Département de Néphrologie et Transplantation d'organes, Hôpital Rangueil, Intensive Care Unit, Centre Hospitalo-Universitaire de Toulouse, 1, Avenue Jean Poulhes, 31059, Toulouse, France.

Background: Rhabdomyolysis is a life-threatening disease that can lead to severe hyperkalemia, acute kidney injury (AKI) and hypovolemic shock. The predictive factors of AKI and acute to chronic kidney disease (CKD) transition remain poorly described.

Methods: This multicenter retrospective study enrolled 387 patients with severe rhabdomyolysis (CPK > 5000 U/L). Read More

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http://dx.doi.org/10.1186/s13613-020-0645-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052098PMC

Natural light exposure and delirium in ICU: does the dark side cloud everything?

Ann Intensive Care 2020 Feb 27;10(1):25. Epub 2020 Feb 27.

Department of Intensive Care Medicine and Infectious Diseases, AP-HP, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, 75018, Paris Cedex, France.

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http://dx.doi.org/10.1186/s13613-020-0643-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046878PMC
February 2020

Impact of corticosteroid treatment on clinical outcomes of influenza-associated ARDS: a nationwide multicenter study.

Ann Intensive Care 2020 Feb 27;10(1):26. Epub 2020 Feb 27.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tz-You 1st Road, Kaohsiung, 807, Taiwan.

Background: Corticosteroid treatment has been widely used in the treatment of septic shock, influenza, and ARDS, although some previous studies discourage its use in severe influenza patients. This multicenter retrospective cohort study conducted in the intensive care units (ICUs) of eight medical centers across Taiwan aims to determine the real-world status of corticosteroid treatment in patients with influenza-associated acute respiratory distress syndrome (ARDS) and its impact on clinical outcomes. Between October 2015 and March 2016, consecutive ICU patients with virology-proven influenza infections who fulfilled ARDS and received invasive mechanical ventilation were enrolled. Read More

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http://dx.doi.org/10.1186/s13613-020-0642-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046839PMC
February 2020

Feasibility, reproducibility and diagnostic usefulness of right ventricular strain by 2-dimensional speckle-tracking echocardiography in ARDS patients: the ARD strain study.

Ann Intensive Care 2020 Feb 13;10(1):24. Epub 2020 Feb 13.

Service de Cardiologie, Institut Lorrain du Cœur et des Vaisseaux, CHRU de Nancy, 54511, Vandoeuvre-lès-Nancy, France.

Background: Right ventricular (RV) function evaluation by echocardiography is key in the management of ICU patients with acute respiratory distress syndrome (ARDS), however, it remains challenging. Quantification of RV deformation by speckle-tracking echocardiography (STE) is a recently available and reproducible technique that provides an integrated analysis of the RV. However, data are scarce regarding its use in critically ill patients. Read More

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http://dx.doi.org/10.1186/s13613-020-0636-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018922PMC
February 2020

Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review.

Ann Intensive Care 2020 Feb 12;10(1):23. Epub 2020 Feb 12.

Department of Intensive Care Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Rationale/methods: The primary aim of the present contribution is to find a literature-based agreement on dose adjustments of vitamin C in critically ill patients undergoing renal replacement therapy (RRT).

Available Data/study Results: Critical illness is frequently accompanied by severe vitamin C deficiency. High-dose supplementation beneficially affects clinical outcome in small cohorts of patients with sepsis, burn injury, and trauma. Read More

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http://dx.doi.org/10.1186/s13613-020-0640-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016079PMC
February 2020