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Ann Oncol 2020 Jul 8. Epub 2020 Jul 8.

University Hospital (CHRU) Besançon, UMR1098 UBFC/EFS/INSERM, Immuno-Oncologie et Biotechnologies en Cancérologie, Besançon, France; EA4340-Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie (BECCOH), Versailles University, Boulogne, France; Ambroise Paré Hospital, AP-HP, Boulogne, France.

Forensic Sci Med Pathol 2020 Jul 10. Epub 2020 Jul 10.

Discipline of Anatomy and Pathology, Adelaide Medical School, The University of Adelaide, Frome Road, Level 2 Helen Mayo Building North, Adelaide, SA, 5005, Australia.

The flagship of the Dutch East India Company (VOC), the Batavia, was wrecked on the morning of the 4th of June 1629 on an isolated reef of the Houtman Abrolhos islands off the coast of Western Australia. The majority of crew and passengers (180-250, including 30 women and children) were able to reach an island which they called Batavia's Graveyard (now known as Beacon Island). After the commander, Francisco Pelsaert, sailed to Batavia for help, Jeronimus Cornelisz took control. Read More

J Hypertens 2020 Jul 6. Epub 2020 Jul 6.

University of Genoa and IRCCS Ospedale Policlinico San Martino, Genova.

Objectives: Long-term visit-to-visit SBP variability (VVV) predicts cerebro-cardiovascular and renal events in patients with hypertension. Whether VVV predicts hypertension and/or chronic kidney disease is currently unknown. We assessed the role of VVV on the development of hypertension and changes in renal function in patients with type 2 diabetes and normal blood pressure (NBP) in a real-life clinical setting. Read More

Ann Transl Med 2020 Jun;8(12):801

Intensive Care Unit, University Hospital Ambroise Paré, APHP, Boulogne Billancourt, France.

Ann Transl Med 2020 Jun;8(12):792

Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an effective mechanical circulatory support modality that rapidly restores systemic perfusion for circulatory failure in patients. Given the huge increase in VA-ECMO use, its optimal management depends on continuous and discrete hemodynamic monitoring. This article provides an overview of VA-ECMO pathophysiology, and the current state of the art in hemodynamic monitoring in patients with VA-ECMO. Read More

Ann Transl Med 2020 Jun;8(12):787

Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Fluid responsiveness is defined as an increase in cardiac output (CO) or stroke volume (SV) of >10-15% after fluid challenge (FC). However, CO or SV monitoring is often not available in clinical practice. The aim of this study was to evaluate whether changes in radial artery pulse pressure (rPP) induced by FC or passive leg raising (PLR) correlates with changes in SV in patients after cardiac surgery. Read More

Ann Transl Med 2020 Jun;8(12):783

Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Ann Transl Med 2020 Jun;8(12):779

Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Ann Transl Med 2020 Jun;8(12):746

Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Background: Neuropsychiatric symptoms (NPS) of dementia are a common issue in dementia patients which can lead to poor medical and functional outcomes. Pharmacological interventions are its treatment of choice. However, whether to use pharmacological treatments in this population and which drug should be preferred remain controversial. Read More

Ann Transl Med 2020 Jun;8(12):743

Department of Colorectal Surgery, Changhai Hospital, Shanghai, China.

Background: Whether adjuvant chemotherapy is beneficial for rectal cancer patients who respond well to neoadjuvant chemoradiotherapy (NCRT) and undergo radical resection is controversial. This study aimed to assess the effect of adjuvant chemotherapy on the oncological outcomes of ypT0-2N0 rectal cancer patients after NCRT and radical resection, and identify the prognostic factors.

Methods: The clinical and pathological data of rectal cancer patients with ypT0-2N0 who underwent NCRT and radical resection between January, 2010 and June, 2018 were collected and retrospectively analyzed. Read More

Ann Transl Med 2020 Jun;8(12):740

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

Background: Prolonged length of stay after surgery is considered to increase cost and hospital-acquired complications. Therefore, we aimed to identify the risk factors that were associated with an increased length of stay after mediastinal tumor resection in the setting of an enhanced recovery after surgery (ERAS)-TUBELESS protocol.

Methods: This prospective cohort study collected data on consecutive patients undergoing video-assisted thoracoscopic surgery (VATS) resection for mediastinal tumor between December 2015 and November 2018 at a single center in China. Read More

Ann Transl Med 2020 Jun;8(12):739

Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China.

Background: Although diabetes mellitus has been reported to aggravate liver ischaemia and reperfusion (IR) injury, the basic mechanism remains largely unknown. The object of the present study was to determine the role of oxidative stress and hepatocellular pyroptosis in liver IR injury in diabetic mice.

Methods: Db/db and C57BL/6 mice at 8 weeks of age were subjected to liver IR injury. Read More

Ann Clin Biochem 2020 Jul 9:4563220944426. Epub 2020 Jul 9.

The London Clinic.

Ann Clin Biochem 2020 Jul 9:4563220944204. Epub 2020 Jul 9.

The London Clinic.

Intensive Care Med 2020 Jul 6. Epub 2020 Jul 6.

Past Editor in Chief, Intensive Care Medicine, Médecine Intensive Et Réanimation, APHP, Hôpital Saint-Louis, Paris University, Paris, France.

Eur Ann Otorhinolaryngol Head Neck Dis 2020 Jul 3. Epub 2020 Jul 3.

Editorial Board, European Annals of Otorhinolaryngology Head & Neck Diseases, Elsevier ed., 92130, Issy-les-Moulineaux, France; Université Paris Centre, 75006, Paris, France.

Objectives: To evaluate biostatistics in scientific articles published in the European Annals of Otorhinolaryngology Head & Neck Diseases.

Materials And Methods: Retrospective analysis of 76 scientific articles published in 2018 and 2019. The main goal was to describe the percentage of articles using biostatistics and to explore for potential associations with the article's main characteristics. Read More

J Law Med Ethics 2020 Jun;48(2):238-240

Robert M. Sade, M.D., is Distinguished University Professor, Professor of Cardiothoracic Surgery, Director of the Institute of Human Values in Health Care, and Director of the South Carolina Clinical and Translational Research Institute (Clinical and Translational Science Award) Clinical Research Ethics Core at the Medical University of South Carolina. He currently chairs the Cardiothoracic Ethics Forum and serves as Associate Editor (Ethics) of the Annals of Thoracic Surgery. He is a former member and chair of the American Association for Thoracic Surgery Ethics Committee, the Society of Thoracic Surgeon's Standards and Ethics Committee, and the American Medical Association's Council on Ethical and Judicial Affairs.

J Law Med Ethics 2020 Jun;48(2):275-278

Jason F. Arnold, J.D., M.P.H., is a fellow at the New York Academy of Medicine and Assistant Director of the Clinical and Translational Research Ethics Program at the Medical University of South Carolina. He serves as Associate Editor (Law and Ethics) of the Journal of Global Health Leadership and as a member of the Clinical Research Ethics Consultation Collaborative, a national network of bioethicists who provide advice on ethical challenges encountered while conducting research. Robert M. Sade, M.D., is Distinguished University Professor, Professor of Cardiothoracic Surgery, Director of the Institute of Human Values in Health Care, and Director of the South Carolina Clinical and Translational Research Institute (Clinical and Translational Science Award) Clinical Research Ethics Core at the Medical University of South Carolina. He currently chairs the Cardiothoracic Ethics Forum and serves as Associate Editor (Ethics) of the Annals of Thoracic Surgery. He is a former chair of the American Association for Thoracic Surgery Ethics Committee, the Society of Thoracic Surgeon's Standards and Ethics Committee, and the American Medical Association's Council on Ethical and Judicial Affairs.

Many studies have shown that marijuana can negatively affect the cognitive development of adolescents. For some individuals, marijuana use may also initiate opioid use, dose escalation, and opioid use disorder. States that legalize marijuana should help adolescents through regulation of advertising and availability of marijuana-infused edibles. Read More

Ann Intern Med 2020 Jul;173(1):79

Ann Intern Med 2020 07;173(1):W3-W9

Brown University, Providence, Rhode Island (S.M.S.).

Ann Intern Med 2020 Jul;173(1):ED1

Ann Intern Med 2020 07;173(1):W1-W2

Mount Sinai School of Medicine, New York, New York (G.E.F.).

Ann Transl Med 2020 Jun;8(11):723

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

Ann Transl Med 2020 Jun;8(11):719

Department of Neurology, David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California, Los Angeles, CA, USA.

Ann Transl Med 2020 Jun;8(11):694

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA.

The spread of COVID-19 has already taken a pandemic form, affecting over 180 countries in a matter of three months. The full continuum of disease ranges from mild, self-limiting illness to severe progressive COVID-19 pneumonia, multiorgan failure, cytokine storm and death. Younger and healthy population is now getting affected than before. Read More

Ann Transl Med 2020 Jun;8(11):693

Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Ohio, USA.

Coronavirus disease 2019 (COVID-19) pandemic has shocked the world and caused morbidity and mortality on an unprecedented level in the era of modern medicine. Evidence generated to-date on the virulence and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suggests that COVID-19 may be considered a perfect storm, caused by a nature's virtually perfect biological weapon. This conclusion is supported by an updated analysis of pathogenesis and clinical progression of this infectious disease. Read More

Ann Transl Med 2020 Jun;8(11):691

Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

Background: Delayed cognitive impairment (DCI) after subarachnoid hemorrhage (SAH) is one of the most common sequelae in patients. This study aimed to investigate the characteristics of the course and glutamatergic pathogenesis of DCI after SAH in mice.

Methods: A SAH mouse model of internal carotid puncture was used. Read More

Ann Transl Med 2020 Jun;8(11):679

Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: The current outbreak of coronavirus disease 2019 (COVID-19), epi-centered in Wuhan, Hubei Province of the China, has become a global health emergency. Several studies from China have recently provided the evidence of epidemiological, clinical, laboratory, and outcomes of COVID-19 patients. Investigation on the role of chest CT in patient screening and management course in a large cohort remains paucity. Read More

Ann Transl Med 2020 Jun;8(11):675

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Long noncoding RNA (lncRNA) in non-homologous end joining pathway 1 (LINP1) contributes to tumorigenesis in various cancers. However, little has been known about the role of LINP1 in esophageal squamous cell carcinoma (ESCC).

Methods: LINP1 was selected as the target lncRNA by bioinformatics analysis. Read More

Ann Transl Med 2020 Jun;8(11):671

Department of Gastroenterology, Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany.

Ann Intern Med 2020 Jul 2. Epub 2020 Jul 2.

Emory University, Atlanta, Georgia (P.J.W.).

Ann Emerg Med 2020 Jul 8;76(1):111-112. Epub 2020 May 8.

MEDStar Washington Hospital, Washington, DC.

Ann Clin Biochem 2020 Jun 26:4563220942263. Epub 2020 Jun 26.

Shandong Provincial Hospital Affiliated to Shandong University.

Ann Clin Biochem 2020 Jun 26:4563220941888. Epub 2020 Jun 26.

First Affiliated Hospital of Soochow University.

Ann Intern Med 2020 07 23;173(1):OC1. Epub 2020 Jun 23.

University of California, San Francisco, San Francisco, California (S.S.).

Ann Intern Med 2020 Jul 23;173(1):W10-W11. Epub 2020 Jun 23.

Medical College of Wisconsin, Milwaukee, Wisconsin (T.M.).

Ann Intern Med 2020 Jun 23. Epub 2020 Jun 23.

None (W.S.).

Ann Transl Med 2020 May;8(9):607

Department of Laboratory Medicine, Naval Special Medical Center, The Naval Military Medical University, Shanghai 200433, China.

Tuberculosis pleural effusion (TPE) is common in clinical practice, and its diagnosis remains a challenge for clinicians. Ziehl-Neelsen staining, PE Mycobacterium tuberculosis culture, and biopsy are the gold standards for TPE diagnosis; however, they are time-consuming, invasive, observer-dependent, and insensitive. PE markers represent a rapid, low-cost, and non-invasive objective diagnostic tool for TPE. Read More

Ann Transl Med 2020 May;8(9):605

Department of Clinical Laboratory, First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China.

Background: Carbapenem-resistant (CRKP) has become an urgent global public health issue, but its distribution has obvious regional differences. The purpose of this study was to investigate the patient-based disease burden and molecular epidemiology of CRKP infections in a tertiary hospital in northern Jiangsu Province in China.

Methods: A retrospective, epidemiological survey of CRKP infections in our hospital from January to December 2016 was conducted to collect clinical and epidemiologic data. Read More

Ann Transl Med 2020 May;8(9):602

Medical Technology School of Xuzhou Medical University, Xuzhou 221004, China.

Background: Urinary tract infection (UTI) is one of the most common hospital-associated infectious. The traditional laboratory diagnosis method for UTI requires at least 24 hours, and it cannot provide the etiology basis for the clinic in time. The aim of our study is to develop a new method for pathogenic diagnosis of UTI by combining matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and UF-5000i from urine samples directly within 1 hour. Read More

Ann Transl Med 2020 May;8(9):601

Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.

Background: Whether routine urinary analysis has a net benefit for urinary tract infection (UTI) screening is unclear.

Methods: Using the laboratory information system (LIS), we retrospectively extracted the data of urine culture and routine analysis between January 2017 and April 2017. Receiver operating characteristic (ROC) curve, logistic regression model, net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were used to estimate the screening performance of routine urinary analysis. Read More

Ann Transl Med 2020 May;8(9):600

Medical Technology School of Xuzhou Medical University, Xuzhou 221004, China.

Ann Transl Med 2020 May;8(9):598

Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.

Ann Transl Med 2020 May;8(9):587

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: Sorafenib has been recommended as the first-line treatment and shown to prolong median overall survival (OS) of patients with advanced unresectable hepatocellular carcinoma (HCC). Recently, a growing amount of research has supported the application of transarterial chemoembolization (TACE) in patients with advanced-stage HCC. The aim of this study was to compare the outcomes of TACE and sorafenib and identify the prognostic factors related to OS for Barcelona Clinic Liver Cancer (BCLC) stage C patients with PS 1 but without vascular invasion or extrahepatic spread. Read More

Ann Transl Med 2020 May;8(9):586

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: Recommended as the first-line treatment for advanced unresectable hepatocellular carcinoma (HCC), sorafenib has been shown to prolong median overall survival (OS) for patients. However, advanced HCC sees high heterogeneity across patient groups. Recently, a growing number of studies have indicated surgical resection and transarterial chemoembolisation (TACE) to perform well in patients with portal vein tumor thrombosis (PVTT). Read More

Ann Transl Med 2020 May;8(9):585

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: Liver resection has been widely applied as a curative measure in the treatment of hepatocellular carcinoma (HCC) patients. However, the high rate of postoperative recurrence observed following liver resection proposes a problem, the solution for which is yet to be well established. Microwave coagulation is a therapy that was recently proposed as an adjuvant tool. Read More

Ann Transl Med 2020 May;8(9):583

Department of Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: Sorafenib has been recommended as the first-line treatment and shown to prolong the median overall survival (OS) of patients with advanced unresectable hepatocellular carcinoma (HCC). Recently, a growing number of earlier studies showed the application of radiofrequency ablation (RFA) plus sorafenib in patients diagnosed at the advanced-stage HCC. This study aimed to compare the outcomes of RFA plus sorafenib versus sorafenib alone and identify prognostic factors related to OS for BCLC stage C patients with PS 1 but without vascular invasion or extrahepatic spread. Read More

Ann Transl Med 2020 May;8(9):580

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background: To study the effectiveness and safety of atrial fibrillation (AF) catheter ablation after pericardiectomy.

Methods: Data of 24 consecutive AF patients after pericardiectomy underwent catheter ablation from five centers were collected and analyzed retrospectively. All patients were followed up at 1, 3, and 12 months after catheter ablation. Read More

Ann Transl Med 2020 May;8(10):657

Department of Orthopaedics, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China.

[This corrects the article DOI: 10.21037/atm.2019. Read More

Ann Transl Med 2020 May;8(10):656

Medical Technology School of Xuzhou Medical University, Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou 221004, China.