964 results match your criteria Annals Of Clinical Psychiatry[Journal]


Emotion regulation accounts for associations between mindfulness and depression across and within diagnostic categories.

Ann Clin Psychiatry 2020 May;32(2):97-106

Department of Psychiatry and Human Behavior, Brown Medical School, Rhode Island Hospital, Providence, RI 05103 USA. E-MAIL:

Background: Previous research shows that mindfulness and emotion regulation (ER) are highly related to each other. Preliminary evidence in small clinical populations show that ER may partially account for the relationship between mindfulness and depressive symptoms. The present study aimed to investigate which diagnostic categories were associated with depressive symptoms after controlling for ER in a heterogeneous sample of treatment-seeking patients. Read More

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Re-examining borderline personality disorder and substance use disorder: The role of emotion dysregulation.

Ann Clin Psychiatry 2020 May 1;32(2). Epub 2020 May 1.

Vermont Center on Behavior and Health, VT 05401-1419 USA. E-MAIL:

Background: Borderline personality disorder (BPD) and substance use disorder (SUD) frequently co-occur. Although some research has investigated the factors related to this comorbidity, few have isolated the effects of SUD on a BPD diagnosis.

Methods: Patients presenting for treatment were assessed with the Structured Clinical Interview for DSM-IV, the BPD module of the Structured Interview for DSM-IV Personality, the Difficulties in Emotion Regulation Scale (DERS), and the Five Facet Mindfulness Questionnaire (FFMQ). Read More

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Examining the characteristics of patients who continue participation in vs those who drop out of a PTSD clinical trial.

Ann Clin Psychiatry 2020 May 1;32(2):e10-e15. Epub 2020 May 1.

Associate Professor and Director, Mood and Trauma Clinic, Department of Psychiatry and Human Behavior, Office of Academic Affairs, Medical College of Georgia at Augusta University, Augusta, Georgia 30912 USA. E-MAIL:

Background: Patients who drop out of clinical trials examining posttraumatic stress disorder (PTSD) may have different characteristics than patients who continue. These characteristics have never been examined in prior PTSD and attrition trials. Our goal was to examine how demographic and clinical characteristics of patients with PTSD impact attrition in a randomized controlled trial. Read More

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May 2020
2.525 Impact Factor

DSM-5 anxious distress specifier in patients with bipolar depression.

Ann Clin Psychiatry 2020 May 1;32(2):e2-e8. Epub 2020 May 1.

Brown Medical School, Providence, RI 02904 USA. E-MAIL:

Background: DSM-5 introduced the anxious distress specifier in recognition of the significance of anxiety in patients who are depressed. Studies have supported the validity of the specifier in patients with major depressive disorder (MDD). In this report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project, we examined the validity of the specifier in patients with bipolar depression. Read More

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Memantine treatment of trichotillomania.

Ann Clin Psychiatry 2020 May;32(2):144-145

Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Pritzker School of Medicine, Chicago, IL 60637 USA E-MAIL:

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New-onset psychosis following initiation of eye movement desensitization and reprocessing therapy.

Ann Clin Psychiatry 2020 May;32(2):142-143

Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA. E-MAIL:

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Pharmacological agents to treat severe neuropsychiatric symptoms in major neurocognitive disorders.

Ann Clin Psychiatry 2020 May;32(2):128-141

Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201 USA. E-MAIL:

Background: Behavioral and psychological symptoms of dementia (BPSD) are challenging to recognize and treat effectively. Despite very effective nonpharmacologic strategies, there are cases where severe BPSD may require biological intervention. The purpose of this review was to clarify safe and evidence-based use of pharmacological agents based on available clinical trial evidence. Read More

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Systematic review of benzodiazepines for anxiety disorders in late life.

Ann Clin Psychiatry 2020 May;32(2):114-127

Chairman, Department of Psychiatry and Behavioral Sciences, Cleveland Clinic Akron General, Akron, OH 44307 USA. E-MAIL:

Background: Benzodiazepines are currently the most commonly prescribed medication for the treatment of anxiety in older adults, although there is a dearth of good-quality data on this subject. The aim of this review was to systematically review studies examining the efficacy and tolerability of benzodiazepines for the treatment of anxiety disorders among older adults.

Methods: The authors conducted a systematic review, searching PubMed, Ovid MEDLINE, Ovid Embase, Web of Science, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials. Read More

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The effects of augmenting clozapine with oxytocin in schizophrenia: An initial case series.

Ann Clin Psychiatry 2020 May;32(2):90-96

Silver Hill Hospital, New Canaan, CT 06840 USA. E-MAIL:

Background: Debilitating symptoms of schizophrenia often persist after sustained treatment with atypical antipsychotics. To date, clozapine has been the most effective of the atypical antipsychotics; however, negative symptoms may persist, indicating a critical need to develop augmenting treatment approaches.

Methods: A retrospective chart review evaluated outcomes for 5 young adult inpatients with treatment-resistant schizophrenia who were prescribed off-label oxytocin (OT; 10 IU/sublingual, 1 time per day, to 20 IU/sublingual, 3 times per day) after their therapeutic response to clozapine plateaued (dose range: 200 to 600 mg). Read More

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Illness narratives and preferences for treatment among older veterans living with treatment-resistant depression and insomnia.

Ann Clin Psychiatry 2020 May;32(2):81-89

Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213 USA. E-MAIL:

Background: Despite the prevalence of comorbid late-life treatmentresistant depression (LLTRD) and insomnia in older adults, there is a gap in the literature describing patient factors, such as patients' beliefs about their illnesses and preferences for treatment, that can facilitate recovery. Therefore, we explored the perceptions and treatment preferences of older veterans with LLTRD and insomnia.

Methods: Semi-structured interviews were completed with 11 older veterans. Read More

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The endless and frequently fallacious quest to identify biomarkers of mental disorders.

Authors:
Richard Balon

Ann Clin Psychiatry 2020 May;32(2):77-79

Departments of Psychiatry and Behavioral Neurosciences and Anesthesiology, Detroit, MI 48201 USA. E-MAIL:

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A systematic review of diffusion tensor imaging studies in drug-naïve OCD patients before and after pharmacotherapy.

Ann Clin Psychiatry 2020 02;32(1):42-47

Saint Louis University School of Medicine, St. Louis, MO 63118 USA, E-MAIL:

Background: Obsessive-compulsive disorder (OCD) is difficult to treat. Studies have shown associations of white matter pathology in OCD, as well as various other psychiatric illnesses, using diffusion tensor imaging (DTI). We conducted a systematic review of controlled studies on drugnaïve patients with OCD vs pharmacologically treated patients with OCD to examine whether pharmacotherapy exerts changes on white matter in OCD. Read More

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February 2020

HERO Wellness Scale: Examining a new mental wellness scale.

Ann Clin Psychiatry 2020 02;32(1):33-40

University of Texas at Austin, School of Nursing, Austin, TX 78712 USA. E-MAIL:

Background: Mental wellness has traditionally not been tracked by mental health clinicians. The aim is to examine the reliability and validity of the HERO Wellness Scale.

Methods: Eighty-four college students (age ≥18) with and without psychiatric morbidity from a small, private college in the north-central United States enrolled in the WILD 5 Wellness Program-a longitudinal, quasi-experimental clinical trial that included 2 groups (intervention and waitlist). Read More

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February 2020

Mood disorders of childhood and adolescence in a low-income, urban community: A retrospective chart review.

Ann Clin Psychiatry 2020 02;32(1):27-32

University Behavioral Health Care, Newark, NJ 07103 USA. E-MAIL:

Background: Our goal was to determine the risk factors that most correlated with mood disorder diagnoses in children in a low-income, urban community.

Methods: We conducted a retrospective chart review of 174 patients age 6 to 18 who were seen between November 2016 and July 2017 at the University Hospital Psychiatric Pediatric Emergency Services in Newark, New Jersey, United States.

Results: Bivariate and multivariate analyses revealed that increasing age, female sex, exposure to trauma, and family history of psychiatric illness were significantly associated with mood disorders in our sample. Read More

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February 2020

A comparison study of the turnaround time for telepsychiatry versus face-to-face consultations in general hospital nonpsychiatric emergency rooms.

Ann Clin Psychiatry 2020 02;32(1):12-16

Associate Chairman, Department of Psychiatry, St. John's Episcopal Hospital, Far Rockaway, NY 11691 USA. E-MAIL:

Background: Psychiatric consultation services, particularly for emergencies, are limited in many parts of the United States. Telepsychiatry services are helping to bridge the gap, and are gaining acceptance and popularity. There is paucity of publications regarding comparison of turnaround time for consultations between video conferencing and traditional face-to-face psychiatric consultations in general hospital nonpsychiatric emergency departments (EDs). Read More

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February 2020

Is the DSM-5 anxious distress specifier sufficient for measuring anxiety in depressed patients? Implications for measurement-based care.

Ann Clin Psychiatry 2020 02;32(1):5-11

Brown Medical School, Providence, RI 02904 USA. E-MAIL:

Background: We examined whether a self-report measure of the DSM-5 anxious distress specifier, the Clinically Useful Depression Outcome Scale Anxious Distress Specifier Subscale (CUDOS-A), was as valid as a broader measure of the severity of anxiety, the Clinically Useful Anxiety Outcome Scale (CUXOS), in patients with depression.

Methods: Two hundred ninety-four patients with major depressive disorder were administered a semi-structured interview. The patients completed self-report measures of depression, anxiety, and irritability. Read More

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February 2020

Are premedical education requirements relevant to medical practice?

Authors:
Donald W Black

Ann Clin Psychiatry 2020 02;32(1):1-3

Department of Psychiatry, Roy J. and Lucille A. Carver, College of Medicine, University of Iowa, Iowa City, IA 52242 USA. E-MAIL:

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February 2020

Smartphone applications for the treatment of depressive symptoms: A meta-analysis and qualitative review.

Ann Clin Psychiatry 2020 02;32(1):48-68

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON M5T 2S8 Canada. E-MAIL:

Background: Emerging research indicates that the use of smartphone mental health applications (apps) could be used as an adjunctive therapy for individuals with depression, especially those who have difficulty accessing conventional therapies. The adoption and ownership of smartphone technology continues to increase in developed and developing nations, and could provide widespread and cost-effective evidence-based treatments for depressive symptoms.

Methods: The primary objective of this meta-analysis was to quantitatively evaluate the effects of smartphone mental health app interventions on depressive symptoms. Read More

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February 2020
2 Reads

Bypassing the blues: Insomnia in the depressed post-CABG population.

Ann Clin Psychiatry 2020 02;32(1):17-26

Western Psychiatric Institute and Clinic, Pittsburgh, PA, 15213 USA. E-MAIL:

Background: BACKGROUND: Recovery from coronary artery bypass graft (CABG) surgery often is complicated by depression and insomnia, resulting in poorer health-related quality of life and clinical outcomes. We explored the relationships among depression, insomnia, quality of life, and the impact of a collaborative care strategy on reducing insomnia in patients after CABG surgery.

Methods: METHODS: Patients with a Patient Health Questionnaire score ≥10 were randomized to nurse-delivered collaborative care for depression (n = 150) or their physician’s usual care (n = 152). Read More

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February 2020
1 Read

Changes in inflammatory biomarkers before and after SSRI therapy in PTSD: A review.

Ann Clin Psychiatry 2019 11;31(4):292-297

Saint Louis University School, of Medicine, St. Louis, MO USA. E-MAIL:

Background: Selective serotonin reuptake inhibitors (SSRIs) are regarded as the standard pharmacotherapy for the treatment of posttraumatic stress disorder (PTSD). Recent studies indicate that neuroinflammation is associated with PTSD. We conducted a search of the literature to determine if SSRI efficacy is associated with a decrease in inflammation levels. Read More

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November 2019
2 Reads

High-dose ketamine infusion for the treatment of posttraumatic stress disorder in combat veterans.

Ann Clin Psychiatry 2019 11;31(4):271-279

Department of Psychiatry, Boston Children's Hospital, Boston, MA USA. E-MAIL:

Introduction: Combat veterans are at high risk for the development of posttraumatic stress disorder (PTSD) and substance use disorders. Ketamine has been shown to be an effective treatment for numerous mental health disorders, although research on its efficacy in combat-related PTSD in veterans is very limited.

Methods: The study population consisted of 30 US military veterans with combat-related PTSD. Read More

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November 2019
2 Reads

The relationship between maternal psychopathology and parental perceptions of their children's reactions in survivors of the 1998 US Embassy bombing in Nairobi, Kenya.

Ann Clin Psychiatry 2019 11;31(4):260-270

Department of Psychiatry and Behavioral Sciences, College of Medicine, University of Oklahoma Health, Sciences Center, Oklahoma City, OK USA. E-MAIL:

Background: The increase in terrorism worldwide has stimulated research on directly and indirectly exposed survivors, but there have been few investigations of the children of highly exposed survivors. This study examined the relationship between parental psychopathology and outcomes in their children who were exposed indirectly to a terrorist incident through their parents' exposures.

Methods: Eight to 10 months after the 1998 US Embassy bombing in Nairobi, Kenya, 280 survivors were interviewed about themselves and their 611 children using the Diagnostic Interview Schedule for DSM-IV to perform a full diagnostic assessment of survivors' pre- and post-disaster psychiatric disorders. Read More

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November 2019
1 Read

Rising placebo response rates threaten the validity of antipsychotic meta-analyses.

Ann Clin Psychiatry 2019 11;31(4):249-259

Department of Psychiatry, Massachusetts General Hospital, Wang 8 Outpatient Psychiatry Clinic, MA, USA. E-MAIL:

Background: Network meta-analyses (NMAs) are an increasingly important tool in comparative psychopharmacology. As do traditional metaanalyses, these studies assume that there are no unaccounted effect modifiers that could confound comparisons across time. Research methodologies, however, have changed markedly in recent decades. Read More

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November 2019
1 Read

Urinary tract infection, inflammation, and cognition in phase 1 of the Clinical Antipsychotic Trials of Intervention Effectiveness Study.

Ann Clin Psychiatry 2019 11;31(4):242-248

Department of Psychiatry and Health Behavior, Augusta University, Augusta, GA USA. E-MAIL:

Background: Schizophrenia is associated with an increased prevalence of infections throughout the life span. Previous studies have found an association between urinary tract infection (UTI) and acute psychosis. We investigated the prevalence and correlates of UTI in a large cohort of patients with schizophrenia. Read More

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November 2019
2 Reads

Paradoxes of retreat from paternalism.

Authors:
Richard Balon

Ann Clin Psychiatry 2019 11;31(4):233-234

Departments of Psychiatry and Behavioral Neurosciences and Anesthesiology, Wayne State University, Detroit, MI 48201 USA. E-MAIL:

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November 2019
1 Read

Antidepressants for anxiety disorders in late-life: A systematic review.

Ann Clin Psychiatry 2019 11;31(4):277-291

Chairman, Department of Psychiatry and Behavioral Sciences, Cleveland Clinic Akron General, Akron, OH USA. E-MAIL:

Background: Anxiety in late-life is a frequently encountered condition. The aim of this review is to systematically examine the efficacy and tolerability of antidepressants for treating anxiety disorders among older adults.

Methods: Electronic searches of The Cochrane Central Register of Controlled Trials and the standard bibliographic databases PubMed, MEDLINE, EMBASE, and PsycINFO were performed in August 2018 and updated in October 2018 for randomized controlled trials (RCTs) evaluating antidepressants for late-life anxiety. Read More

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November 2019
4 Reads

Impact of repetitive transcranial magnetic stimulation on generalized anxiety disorder in treatment-resistant depression.

Ann Clin Psychiatry 2019 11;31(4):236-241

BACKGROUND: Published evidence indicates the value of repetitive transcranial magnetic stimulation (rTMS) for generalized anxiety disorder in patients with treatment-resistant depression (TRD). As a part of routine clinical service, patients with TRD received right dorsolateral prefrontal cortex (DLPFC) inhibitory rTMS immediately prior to left DLPFC depression treatment delivered according to a US Food and Drug Administration protocol. METHODS: A retrospective investigation of routinely collected data between 2016 and 2018 was undertaken. Measures used were the clinicianrated Clinical Global Impressions-Severity (CGI-S) scale and Hamilton Depression Rating scale (HAM-D), and the patient-rated Generalized Anxiety Disorder scale-7 (GAD-7) and Patient Health Questionnaire (PHQ-9). The outcome data of 61 patients with TRD were analyzed. The sample included patients with comorbid psychiatric diagnoses. RESULTS: Response and remission rates, respectively, were 17.1% and 27.3% on the GAD-7; 20.7% and 12.5% on the HAM-D; 19% and 24% on the PHQ-9; and 20% and 23.5% on the CGI-S. Post-treatment scores significantly improved on the GAD-7, HAM-D, and CGI-S scales, with medium to large effect sizes (.61, .62, and .86 respectively). CONCLUSIONS: Results indicate the potential value of rTMS in treating anxiety in patients who are referred for rTMS for TRD. Well-designed and adequately powered randomized controlled trials are required to determine clinical recommendations.

Background: Published evidence indicates the value of repetitive transcranial magnetic stimulation (rTMS) for generalized anxiety disorder in patients with treatment-resistant depression (TRD). As a part of routine clinical service, patients with TRD received right dorsolateral prefrontal cortex (DLPFC) inhibitory rTMS immediately prior to left DLPFC depression treatment delivered according to a US Food and Drug Administration protocol.

Methods: A retrospective investigation of routinely collected data between 2016 and 2018 was undertaken. Read More

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November 2019
2 Reads

Can catatonia be a pathological response to fear and trauma?

Ann Clin Psychiatry 2019 08;31(3):222-223

Nagy A. Youssef, MD, Department of Psychiatry and Human Behavior, Office of Academic Affairs, Medical College of Georgia, Augusta University, Augusta, GA USA. E-MAIL:

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August 2019
2.525 Impact Factor

Low high-density lipoprotein and psychopathology: A review.

Ann Clin Psychiatry 2019 08;31(3):209-213

Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, St. Louis, MO USA. E-MAIL:

Background: An association between the level of total cholesterol and psychopathology has been the focus of numerous studies. Low total cholesterol has been found to be related to depression, personality disorders, and dissociative disorder. High cholesterol has been associated with schizophrenia, obsessive-compulsive disorder (OCD), panic disorder, generalized anxiety disorder, and posttraumatic stress disorder. Read More

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August 2019
7 Reads

A national study for regional variation of inpatient ECT utilization from 4,411 hospitals across the United States.

Ann Clin Psychiatry 2019 08;31(3):200-208

Department of Psychiatry and Health Behavior, Office of Academic Affairs, Medical College of Georgia, Augusta University, Augusta, GA 30912 USA. E-MAIL"

Background: We conducted a study to examine regional variation in the utilization of inpatient electroconvulsive therapy (ECT) across the United States, and its impact on length of hospital stay and cost.

Methods: Analysis of the Nationwide Inpatient Sample databases to compare patient and hospital characteristics, and regional variation of ECT administration across different regions of the United States.

Results: The study included 41,055 inpatients who had ECT from 4,411 hospitals. Read More

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August 2019
2 Reads
2.525 Impact Factor

Cognitive-behavioral therapy booster treatment in pediatric obsessive-compulsive disorder: A utilization assessment pilot study.

Ann Clin Psychiatry 2019 08;31(3):179-191

BC Children's Hospital A3, Vancouver, BC, Canada. E-MAIL:

Background: Cognitive-behavioral therapy (CBT) for pediatric obsessivecompulsive disorder (OCD) is effective, although many individuals report they need continued support after completing treatment.

Methods: Six monthly drop-in booster sessions were offered to 94 youth with OCD and their parents who previously had completed a 12-week group family-based CBT program (GF-CBT). This report describes program utilization rates and participant satisfaction levels. Read More

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August 2019
2 Reads

A latent profile analysis of age of onset in trichotillomania.

Ann Clin Psychiatry 2019 08;31(3):169-178

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90024-5055 USA. E-MAIL:

Background: Trichotillomania (TTM) onset may occur across the lifespan; however, adolescent onset is most frequently reported. Several studies have explored clinical differences between TTM age-of-onset groups with mixed results. We investigated empirically defined age-of-onset groups in adults with TTM, and clinical differences between groups. Read More

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August 2019
2 Reads
2.525 Impact Factor

Ecopipam as a pharmacologic treatment of stuttering.

Ann Clin Psychiatry 2019 08;31(3):164-168

Professor and Chair of Psychiatry and Neuroscience, University of California, Riverside, School of Medicine, CA 92521 USA. E-MAIL:

Background: Stuttering, also known as childhood-onset fluency disorder, is a chronic neurodevelopmental disorder that affects 1% of the population and can greatly impact an individual's social, occupational, and academic functioning. Prior research has shown dopamine D2 antagonists are effective in reducing the severity of stuttering symptoms, but these compounds can be associated with metabolic and movement disorder adverse effects. Ecopipam is an investigational medication that acts as a selective dopamine D1 receptor antagonist. Read More

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August 2019
1 Read

Stigma of mental illness and us.

Ann Clin Psychiatry 2019 08;31(3):161-162

Departments of Psychiatry and Behavioral Neurosciences and Anesthesiology, Wayne State University, Detroit, MI 48201 USA. E-MAIL:

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Bidirectional relationship between transient ischemic attacks and depression: A review.

Ann Clin Psychiatry 2019 08;31(3):214-220

Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, Monteleone Hall, St. Louis, MO 63104 USA. E-MAIL:

Background: An association between cerebrovascular events and psychiatric disorders has been reported. However, the focus has centered on stroke, and there has been a lack of attention to a possible relationship between transient ischemic attacks (TIAs) and depression.

Methods: We conducted a review of studies that looked specifically at the risk of depression after TIAs and the risk of TIAs in patients with depression. Read More

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August 2019
20 Reads

Rational deprescribing in the elderly.

Ann Clin Psychiatry 2019 05;31(2):144-152

Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School, of Medicine, St. Louis, MO 63104 USA. E-MAIL:

Background: Polypharmacy, defined as being prescribed 5 or more medications, has been shown to be associated with a decline in mental and physical functioning in elderly patients. Despite this, elderly patients are currently being prescribed a median of 7 medications, which often causes more harm than benefit, and emphasizes the importance of deprescribing.

Methods: Five classes of potentially inappropriate medications for the elderly population, especially for the aging brain, are discussed, including anticholinergics, benzodiazepines, antipsychotics, opioids, and proton pump inhibitors. Read More

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May 2019
7 Reads

A focus on postpartum depression among African American women: A literature review.

Ann Clin Psychiatry 2019 05;31(2):138-143

Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, St. Louis, MO 63104 USA. E-MAIL:

Background: Some studies have reported a higher rate of postpartum depression in African American vs White women. We reviewed the literature to identify the possible factors associated with a greater risk of postpartum depression in African American women.

Methods: A comprehensive literature review was conducted using journal databases such as PubMed and Google Scholar. Read More

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May 2019
8 Reads

Subthreshold depression and its association with cardiovascular risk.

Ann Clin Psychiatry 2019 05;31(2):130-136

New York State Psychiatric Institute, Columbia University, New York, NY 10032 USA. E-MAIL:

Background: Cardiovascular disease (CVD) is a widespread condition that is associated with significant morbidity, mortality, and cost. It is considered one of the leading causes of death in the world. Individuals with CVD and major depressive disorder have greater morbidity and mortality. Read More

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May 2019
1 Read

Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial.

Ann Clin Psychiatry 2019 05;31(2):123-129

Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 USA. E-MAIL:

Background: Extracts of Withania somnifera (WSE), or Ashwagandha, has traditionally been used as an adaptogen in Ayurvedic medicine, and evidence suggests that it may have efficacy in the treatment of psychiatric disorders, including schizophrenia. This secondary analysis reviewed change in depression and anxiety symptoms in a study using WSE as an adjunctive treatment in patients with schizophrenia experiencing an exacerbation of positive symptoms.

Methods: We enrolled patients with schizophrenia in a 12-week, randomized, placebo-controlled, double-blind study. Read More

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May 2019
13 Reads

Depressive symptom severity mediates the association between sleep disturbance and obesity in US adults: Results from the NHANES.

Ann Clin Psychiatry 2019 05;31(2):111-122

Mood Disorders, Psychopharmacology Unit, University Health Network, Toronto, ON, Canada. E-MAIL:

Background: The clustering of sleep alterations, cardiometabolic risk, and depressive symptoms suggests a convergence in their pathophysiology. We quantify the role of depressive symptoms in mediating the association between empirically derived sleep indices and body mass index (BMI).

Methods: Data were derived from 8,844 adult participants of the 2005 to 2008 US National Health and Nutrition Examination Survey. Read More

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May 2019
4 Reads
2.525 Impact Factor

The sound of music: A rare case of auditory Charles Bonnet syndrome in an elderly male.

Ann Clin Psychiatry 2019 05;31(2):107-110

Associate Chairman, Department of Psychiatry, St. John's Episcopal Hospital. E-MAIL:

Background: Auditory Charles Bonnet syndrome describes a rare condition that presents with sensorineural hearing loss, which can result in musical hallucinations.

Methods: A Hispanic man, age 78, with no previous psychiatric history was evaluated at our clinic with a complaint of hearing voices and music. The patient was noted to have received cochlear implantation in his right ear in 2013, due to bilateral sensorineural hearing loss. Read More

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May 2019
4 Reads

Co-occurrence of depression with chronic diseases among the older population living in low- and middle-income countries: A compound health challenge.

Ann Clin Psychiatry 2019 05;31(2):95-105

Faculty of Health, Deakin University, Melbourne Campus at Burwood, Burwood, Australia. E-MAIL:

Background: Few studies have examined the associations between mental and physical health conditions in low- and middle-income countries (LMICs). The aim of this study was to evaluate comorbidity of depression and other chronic diseases in community-dwelling older adults.

Methods: Data were obtained from the World Health Organization Study on global AGEing and adult health (SAGE) implemented in 6 LMICs: China, Ghana, India, Mexico, the Russian Federation, and South Africa. Read More

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May 2019
4 Reads

Group therapy for excoriation disorder: Psychodrama versus support therapy.

Ann Clin Psychiatry 2019 05;31(2):84-94

Universidade de São Paulo, São Paulo, Brasil. E-MAIL:

Background: Excoriation disorder (ED) is characterized by recurring excoriation of the skin resulting in tissue damage, usually associated with emotional deregulation. Psychotherapy is a valuable treatment; however, no studies emphasize the patients' interactional aspect, nor the potential benefit of group treatment.

Methods: We recruited a convenience sample of 38 individuals with ED according to DSM-5 criteria, in which 19 individuals proceeded to treatment, 10 with psychodrama group therapy (PGT), and 9 with support group therapy (SGT) in an open pilot study. Read More

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May 2019
5 Reads

The madness of mandated wellness.

Ann Clin Psychiatry 2019 05;31(2):81-82

Departments of Psychiatry and Behavioral Neurosciences and Anesthesiology, Wayne State University, Detroit, MI 48201 USA. E-MAIL:

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May 2019
2 Reads

Intensity-dependent, disabling exercise-induced depression and irritability without primary mood disorder.

Ann Clin Psychiatry 2019 02;31(1):70-71

Department of Psychiatry and Health Behavior, Office of Academic Affairs, Medical College of Georgia, Augusta University, Augusta, GA 30912 USA. E-MAIL:

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February 2019
2 Reads
2.525 Impact Factor

Evidence for using PRN pharmacotherapy to treat undifferentiated acute agitation or aggression.

Ann Clin Psychiatry 2019 02;31(1):54-69

Chairman, Department of Psychiatry and Behavioral Sciences, Cleveland Clinic Akron General, Akron, Ohio, 44307 USA. E-MAIL:

Background: This systematic review identified published studies that evaluated the use of (PRN) medication in patients with acute agitation or aggression of undifferentiated etiology.

Methods: A literature search was conducted of PubMed and MEDLINE for randomized controlled trials (RCTs) that evaluated the use of PRN medications for individuals with undifferentiated agitation or aggression. Bibliographic databases of published articles were also searched for additional studies. Read More

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February 2019
8 Reads