3,188 results match your criteria Annals Of Carnegie Museum[Journal]


The neglected biliary mucus and its phosphatidylcholine content: a putative player in pathogenesis of primary cholangitis-a narrative review article.

Ann Transl Med 2021 Apr;9(8):738

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

Primary sclerosing cholangitis (PSC) is a rare progressive cholangitis resulting in cirrhosis and cholangiocellular carcinoma. The pathogenesis is unclear and an effective medical therapy is not available. It is highly associated to ulcerative colitis for which recently a disturbance of the tight junction (TJ) barrier has been claimed as etiologic feature. Read More

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Liver failure-future challenges and remaining questions.

Ann Transl Med 2021 Apr;9(8):734

Department of Medicine, Ruhr University Bochum, University Hospital Knappschaftskrankenhaus Bochum, Bochum, Germany.

This review compiles the current state of controversial aspects of liver failure and outlines future challenges. The definition of acute liver failure (ALF) is widely accepted and implies no previous liver injury whereas the term "acute-on-chronic liver failure" remains contested. We will promote a concept, in which we differentiate three types of liver failure: ALF, acute-on-chronic liver failure (AOCLF) and acute-on-liver-cirrhosis (AOCi). Read More

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Therapeutic strategies in Wilson disease: pathophysiology and mode of action.

Ann Transl Med 2021 Apr;9(8):732

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

Wilson disease is a copper overload disease treatable with the chelators D-penicillamine and trientine to enhance urinary excretion or with zinc which predominantly inhibits absorption. By lifelong treatment a normal life expectancy and significant improvement of hepatic injury as well as neurologic manifestation is achievable. Here we evaluate the mode of action for effective therapy of Wilson disease. Read More

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Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention.

Ann Transl Med 2021 Apr;9(8):729

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.

Liver fibrosis is the excessive expression and accumulation of extracellular matrix proteins in the liver. Fibrotic scarring occurs as the consequence of chronic injury and inflammation. While the successful treatment of hepatitis B and C reduced the burden of liver disease related to viral hepatitis, non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) are nowadays the leading causes of hepatic fibrosis worldwide. Read More

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It's all about the spaces between cells: role of extracellular matrix in liver fibrosis.

Ann Transl Med 2021 Apr;9(8):728

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.

Liver fibrosis is one of the leading complications of a variety of chronic liver disorders, including the nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, liver cirrhosis and liver failure. The progression of liver fibrosis is driven by chronic inflammation, which activates the secretory fibroblasts to the myofibroblast phenotype. These specialized liver cells are called as hepatic stellate cells (HSCs). Read More

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Unresolved basic issues in hepatology.

Ann Transl Med 2021 Apr;9(8):725

Practice for Gastroenterology, Medical Center Baden-Baden, Baden-Baden, Germany. (Email:

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Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells.

Ann Transl Med 2021 Apr;9(8):631

School of Medicine, Southeast University, Nanjing, China.

Background: Lycopene is a naturally occurring carotenoid found in many fruits and vegetables, which has antioxidant effects. Although lycopene's protective effect has been observed on ischemia reperfusion (IR) injury in different organs, the effect of lycopene on Kupffer cells (KCs) has not been clearly elucidated in IR-induced acute hepatic inflammatory injury.

Methods: Mice were administered with either olive oil (10 mL/kg body weight) as the control or lycopene (20 mg/kg body weight) by gavage for 2 weeks before undergoing hepatic IR injury. Read More

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Epidemiological and clinical characteristics of suspected COVID-19 patients in the isolation ward in Guangzhou, China: a cohort study.

Ann Transl Med 2021 Apr;9(8):621

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Since there are reports of cases of 2019-coronavirus disease (COVID-19) asymptomatic carriers in China recently and fever is one of the main symptoms, we aimed to distinguish COVID-19 cases from other febrile patients with clinical examinations in this study.

Methods: A total of 134 suspected COVID-19 patients in the isolation ward of the First Affiliated Hospital of Guangzhou Medical University were recruited from January 23 to May 23, 2020. We analyze the pathogenic form and clinical characteristics. Read More

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Inhaled pulmonary vasodilators: a narrative review.

Ann Transl Med 2021 Apr;9(7):597

Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Pulmonary hypertension (PH) is a severe disease that affects people of all ages. It can occur as an idiopathic disorder at birth or as part of a variety of cardiovascular and pulmonary disorders. Inhaled pulmonary vasodilators (IPV) can reduce pulmonary vascular resistance (PVR) and improve RV function with minimal systemic effects. Read More

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How will emerging SARS-CoV-2 variants impact herd immunity?

Ann Transl Med 2021 Apr;9(7):585

Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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Rationale and design of a prospective, multicenter, cross-sectional study of appropriateness evaluation of the prescription of non-vitamin K antagonist oral anticoagulants for Chinese atrial fibrillation patients (Chi-NOACs-AF trial).

Ann Transl Med 2021 Apr;9(7):580

Department of Pharmacy, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: Non-vitamin K antagonist oral anticoagulants (NOACs) are alternative to vitamin K antagonists (VKAs) for stroke prevention in patients with atrial fibrillation (AF). Along with their widespread clinical use in China, the off-label use of NOACs is commonly seen in real-world practice, which could result in adverse drug events and poor clinical outcomes. However, guideline adherence and label adherence for NOAC prescriptions have not been well evaluated in a real-world setting in China. Read More

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A narrative review of exosomes in vascular calcification.

Ann Transl Med 2021 Apr;9(7):579

Department of nephrology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, China.

Vascular calcification (VC) is the abnormal deposition of calcium, phosphorus, and other minerals in the vessel wall and can be commonly observed in diabetes, chronic kidney disease, and chronic inflammatory disease. It is closely associated with mortality from cardiovascular events. Traditionally, calcification is considered as a degenerative disease associated with the aging process, while increasing evidence has shown that the occurrence and development of calcification is an active biological process, which is highly regulated by multiple factors. Read More

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Evolutions in the Management of Hepatocellular Carcinoma over Last 4 Decades: An Analysis from the 100 Most Influential Articles in the Field.

Liver Cancer 2021 Apr 2;10(2):137-150. Epub 2021 Feb 2.

Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC and Chinese Academy of Medical Sciences, Beijing, China.

Introduction: Over the past 4 decades, the management of hepatocellular carcinoma (HCC) has changed dramatically. The publications that have had the most significant impact on HCC management have not been quantitatively analyzed. In this article, we analyzed the 100 most influential articles over the past 4 decades using bibliometric citation analysis to characterize the evolution in HCC treatment. Read More

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Tenth Dedicated CSPS Annals.

Ann Plast Surg 2021 05;86(5S Suppl 3):S353

From the Division of Plastic Surgery, Stanford University, Palo Alto, CA.

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Annals Graphic Medicine - Intern Year 2020: Expectations Versus Reality.

Authors:
Diana Zychowski

Ann Intern Med 2021 May 11. Epub 2021 May 11.

University of Minnesota, Minneapolis, Minnesota (D.Z.).

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The power of wonder.

Authors:
Richard Rass

Ann N Y Acad Sci 2021 May 4. Epub 2021 May 4.

The Nour Foundation, New York, New York.

The broad implications of acknowledging and embracing the emotions of awe and wonder are discussed in this special issue of Annals of the New York Academy of Sciences, from their role as an incentive or impediment to scientific progress, to the many ways in which they connect to aesthetic experience, religious attitudes, and ethical concerns. Read More

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Annals On Call - The Problem of Conflicting Guidelines.

Ann Intern Med 2021 May 4:OC1. Epub 2021 May 4.

University of Alabama at Birmingham, Birmingham, Alabama (T.M.S.).

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Annals Graphic Medicine - The Social Impact of COVID-19.

Authors:
Sujal Manohar

Ann Intern Med 2021 May 4. Epub 2021 May 4.

Duke University, Durham, North Carolina (S.M.).

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A Methodological Appraisal of the HEART Score and Its Variants.

Ann Emerg Med 2021 Apr 28. Epub 2021 Apr 28.

Department of Emergency Medicine, University of California, Los Angeles, Los Angeles, CA.

We performed a methodological appraisal of the history, electrocardiogram, age, risk factors, and troponin (HEART) score and its variants in the context of Annals of Emergency Medicine's methodological standards for clinical decision rules. We note that this chest pain risk stratification tool was not formally derived, omits sex and other known predictors, has weak interrater reliability, and its 0, 1, and 2 score weightings do not align with their known predictivities. Its summary performance (pooled sensitivities of 96% to 97% with lower confidence interval bounds of 93% to 94%) is below that which emergency physicians state a willingness to accept, below the 98% sensitivity exhibited by baseline practice without the score, and below the 1% to 2% acceptable miss threshold specified by the American College of Emergency Physicians chest pain policy. Read More

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Intent to share Annals of Internal Medicine's trial data was not associated with data re-use.

J Clin Epidemiol 2021 Apr 26. Epub 2021 Apr 26.

Univ Rennes, CHU Rennes, Inserm, CIC 1414 [(Centre d'Investigation Clinique de Rennes)], F-35000 Rennes, France.

Objective: To explore the impact of the Annals of Internal Medicine (AIM) data-sharing policy for randomized controlled trials (RCTs) in terms of output from data-sharing (i.e. publications re-using the data). Read More

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How Has Improved the Scientific Quality and Ethical Standards of its Articles in the Two-Year Period since October 2018.

Authors:
Sun Huh

Ann Dermatol 2020 Oct 29;32(5):353-359. Epub 2020 Sep 29.

Department of Parasitology and Institute of Medical Education, College of Medicine, Hallym University, Chuncheon, Korea.

has not been deposited in PubMed Central (PMC) since October 2018 due to inadequate scientific quality, including the absence of informed consent in three case reports with patients' photos. This study examined the readiness of to be deposited in PMC again by analyzing the 13 issues published from October 2018 to August 2020. The journal's scientific quality and ethical standards were assessed, and adherence to these standards was documented. Read More

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October 2020

Annals Graphic Medicine - Dr. Mom: Every Night.

Authors:
Grace E Farris

Ann Intern Med 2021 Apr 27. Epub 2021 Apr 27.

University of Texas, Austin, Texas (G.E.F.).

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Annals for Hospitalists Inpatient Notes - Direct Oral Anticoagulants in Patients With Cancer-What Hospitalists Need to Know.

Authors:
Agnes Y Y Lee

Ann Intern Med 2021 Apr;174(4):HO2-HO3

University of British Columbia, BC Cancer, and Vancouver Coastal Health Authority, Vancouver, British Columbia, Canada (A.Y.Y.L.).

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Annals for Hospitalists - April 2021.

Ann Intern Med 2021 Apr;174(4):HO4

From Michigan Medicine and VA Ann Arbor Healthcare System, Ann Arbor, Michigan (D.H.W, J.A., M.L.).

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Annals On Call - Syncope: Who Is at Risk for Poor Outcomes?

Ann Intern Med 2021 Apr;174(4):OC2

University of Ottawa and Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada (V.T.).

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Annals Consult Guys - A Recent Stroke: Can You Decrease the Risk for Perioperative Stroke?

Ann Intern Med 2021 04;174(4):CG1

Thomas Jefferson University, Philadelphia, Pennsylvania (G.J.M., H.H.W.).

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