5,894 results match your criteria Annals Of Biomedical Engineering[Journal]


Vaccine Hesitancy and Betrayal Aversion.

Ann Biomed Eng 2022 May 17. Epub 2022 May 17.

Department of Economics, Virginia Tech, Blacksburg, VA, 24061, USA.

The determinants of vaccine hesitancy remain complex and context specific. Betrayal aversion occurs when an individual is hesitant to risk being betrayed in an environment involving trust. In this pre-registered vignette experiment, we show that betrayal aversion is not captured by current vaccine hesitancy measures despite representing a significant source of unwillingness to be vaccinated. Read More

View Article and Full-Text PDF

Psychophysical Evaluation of Proprioceptive Feedback Through a Probe Sliding on the Forearm Skin of Healthy Humans.

Ann Biomed Eng 2022 May 17. Epub 2022 May 17.

Biomedical Engineering Department, Tekirdağ Namık Kemal University, Silahtaraga Mh. Universite 1. Sk. No: 13, 59860, Çorlu, Tekirdag, Turkey.

We have tested the forearm skin of humans as a target organ to deliver proprioceptive feedback via a tactile sensory substitution method. In the proposed method, a contactor probe was actuated by a linear servo motor and moved on the skin in proximo-distal axis depending on the angle of a virtual joint moving on a 180° arc. Twenty healthy subjects were tested to stop the joint at a given target under no-feedback, visual feedback, and tactile (dorsal and volar) feedback conditions. Read More

View Article and Full-Text PDF

Effect of Angiogenesis in Bone Tissue Engineering.

Ann Biomed Eng 2022 May 7. Epub 2022 May 7.

Department of Orthopedics, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, People's Republic of China.

The reconstruction of large skeletal defects is still a tricky challenge in orthopedics. The newly formed bone tissue migrates sluggishly from the periphery to the center of the scaffold due to the restrictions of exchange of oxygen and nutrition impotent cells osteogenic differentiation. Angiogenesis plays an important role in bone reconstruction and more and more studies on angiogenesis in bone tissue engineering had been published. Read More

View Article and Full-Text PDF

Particle Distribution in Embolotherapy, How Do They Get There? A Critical Review of the Factors Affecting Arterial Distribution of Embolic Particles.

Ann Biomed Eng 2022 May 6. Epub 2022 May 6.

Department of Vascular and Interventional Radiology, University of Minnesota, Minneapolis, MN, USA.

Embolization has tremendously evolved in recent years and has expanded to treatment of a variety of pathologic processes. There has been emerging evidence that the level of arterial occlusion and the distribution of embolic particles may play an important role in the clinical outcome. This is a comprehensive literature review to identify variables that play important role in determination of level of occlusion of blood vessels and distribution of embolic particles. Read More

View Article and Full-Text PDF

Head Impact Exposure in Youth and Collegiate American Football.

Ann Biomed Eng 2022 May 4. Epub 2022 May 4.

Department of Orthopaedics, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, 1 Hoppin Street, Suite 402C Coro West, Providence, RI, 02903, USA.

The relationship between head impact and subsequent brain injury for American football players is not well-defined, especially for youth. The objective of this study is to quantify and assess Head Impact Exposure (HIE) metrics among youth and collegiate football players. This multi-season study enrolled 639 unique athletes (354 collegiate; 285 youth, ages 9-14), recording 476,209 head impacts (367,337 collegiate; 108,872 youth) over 971 sessions (480 collegiate; 491 youth). Read More

View Article and Full-Text PDF

Effects of Back-Support Exoskeleton Use on Lower Limb Joint Kinematics and Kinetics During Level Walking.

Ann Biomed Eng 2022 Apr 27. Epub 2022 Apr 27.

Department of Industrial Engineering, Clemson University, Freeman Hall, Clemson, SC, 29634, USA.

We assessed the effects of using a passive back-support exoskeleton (BSE) on lower limb joint kinematics and kinetics during level walking. Twenty young, healthy participants completed level walking trials while wearing a BSE (backX) with three different levels of hip-extension support torque (i.e. Read More

View Article and Full-Text PDF

A Preliminary Study on the Usage of a Data-Driven Probabilistic Approach to Predict Valve Performance Under Different Physiological Conditions.

Ann Biomed Eng 2022 Apr 26. Epub 2022 Apr 26.

Biomedical Engineering Department, Michigan Technological University, Houghton, MI, USA.

Predicting potential complications after aortic valve replacement (AVR) is a crucial task that would help pre-planning procedures. The goal of this work is to generate data-driven models based on logistic regression, where the probability of developing transvalvular pressure gradient (DP) that exceeds 20 mmHg under different physiological conditions can be estimated without running extensive experimental or computational methods. The hemodynamic assessment of a 26 mm SAPIEN 3 transcatheter aortic valve and a 25 mm Magna Ease surgical aortic valve was performed under pulsatile conditions of a large range of systolic blood pressures (SBP; 100-180 mmHg), diastolic blood pressures (DBP; 40-100 mmHg), and heart rates of 60, 90 and 120 bpm. Read More

View Article and Full-Text PDF

A Compressed Collagen Construct for Studying Endothelial-Smooth Muscle Cell Interaction Under High Shear Stress.

Ann Biomed Eng 2022 Apr 26. Epub 2022 Apr 26.

Department of Mechanical Systems Engineering, Tokyo Metropolitan University, Minami-Osawa 1-1, Hachioji, Tokyo, 192-0397, Japan.

The coculture of vascular endothelial cells (ECs) on collagen gels containing smooth muscle cells (SMCs) has been carried out to investigate cellular interactions associated with blood vessel pathophysiology under wall shear stress (WSS) conditions. However, due to a lack of gel stiffness, the previous collagen gel coculture constructs are difficult to use for pathologic higher WSS conditions. Here, we newly constructed a coculture model with centrifugally compressed cell-collagen combined construct (C6), which withstands higher WSS conditions. Read More

View Article and Full-Text PDF

Change in Lumbar Muscle Size and Composition on MRI with Long-Duration Spaceflight.

Ann Biomed Eng 2022 Apr 22. Epub 2022 Apr 22.

Department of Biomedical Engineering, Center for Injury Biomechanics, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Prolonged microgravity results in muscle atrophy, especially among the anti-gravity spinal muscles. How individual paravertebral muscle groups change in size and composition with spaceflight needs further exploration. This study investigates lumbar spine musculature changes among six crewmembers on long-duration space missions using non-invasive measurement of muscle changes with magnetic resonance imaging (MRI). Read More

View Article and Full-Text PDF

Computational Investigation of Anastomosis Options of a Right-Heart Pump to Patient Specific Pulmonary Arteries.

Ann Biomed Eng 2022 Apr 22. Epub 2022 Apr 22.

Department of Biomedical Engineering, The Pennsylvania State University, 122 Chemical and Biomedical Engineering Building, University Park, PA, 16802-4400, USA.

Patients with Fontan circulation have increased risk of heart failure, but are not always candidates for heart transplant, leading to the development of the subpulmonic Penn State Fontan Circulation Assist Device. The aim of this study was to use patient-specific computational fluid dynamics simulations to evaluate anastomosis options for implanting this device. Simulations were performed of the pre-surgical anatomy as well as four surgical options: a T-junction and three Y-grafts. Read More

View Article and Full-Text PDF

Alginate-Based Hydrogels and Tubes, as Biological Macromolecule-Based Platforms for Peripheral Nerve Tissue Engineering: A Review.

Ann Biomed Eng 2022 Jun 21;50(6):628-653. Epub 2022 Apr 21.

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.

Unlike the central nervous system, the peripheral nervous system (PNS) has an inherent capacity to regenerate following injury. However, in the case of large nerve defects where end-to-end cooptation of two nerve stumps is not tension-free, autologous nerve grafting is often utilized to bridge the nerve gaps. To address the challenges associated with autologous nerve grafting, neural guidance channels (NGCs) have been successfully translated into clinic. Read More

View Article and Full-Text PDF

Machine Learning for Cardiovascular Biomechanics Modeling: Challenges and Beyond.

Ann Biomed Eng 2022 Jun 20;50(6):615-627. Epub 2022 Apr 20.

Department of Mechanical Engineering, University of California Berkeley, Berkeley, CA, USA.

Recent progress in machine learning (ML), together with advanced computational power, have provided new research opportunities in cardiovascular modeling. While classifying patient outcomes and medical image segmentation with ML have already shown significant promising results, ML for the prediction of biomechanics such as blood flow or tissue dynamics is in its infancy. This perspective article discusses some of the challenges in using ML for replacing well-established physics-based models in cardiovascular biomechanics. Read More

View Article and Full-Text PDF

The Effect of MIPS, Headform Condition, and Impact Orientation on Headform Kinematics Across a Range of Impact Speeds During Oblique Bicycle Helmet Impacts.

Ann Biomed Eng 2022 Apr 19. Epub 2022 Apr 19.

MEA Forensic Engineers & Scientists, 23281 Vista Grande Drive, Laguna Hills, CA, 92653, USA.

Bicycle helmets are designed to attenuate both the linear and rotational response of the head during an oblique impact. Here we sought to quantify how the effectiveness of one popular rotation-attenuating system (MIPS) varied across 3 test headform conditions (bare, covered in stockings, and hair), 3 oblique impact orientations, and 4 impact speeds. We conducted 72 freefall drop tests of a single helmet model with and without MIPS onto a 45° angled anvil and measured the peak linear (PLA) and angular acceleration (PAA) and computed the angular velocity change (PAV) and brain injury criterion (BrIC). Read More

View Article and Full-Text PDF

Electrospun Polysaccharides for Periodontal Tissue Engineering: A Review of Recent Advances and Future Perspectives.

Ann Biomed Eng 2022 Apr 15. Epub 2022 Apr 15.

Nanchang Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, 637000, China.

Periodontitis is the leading cause of tooth loss among the adult population. Indeed, conventional treatment modalities have specific challenges such as scar tissue infiltration, the formation of long epithelium junctions, and aesthetic limitations. Therefore, the development of alternative strategies is highly demanded. Read More

View Article and Full-Text PDF

Image Registration-Based Method for Reconstructing Transcatheter Heart Valve Geometry from Patient-Specific CT Scans.

Ann Biomed Eng 2022 Apr 15. Epub 2022 Apr 15.

Department of Biomedical Engineering, Georgia Institute of Technology, 387 Technology Circle | Office 232, Atlanta, GA, 30313-2412, USA.

Accurate reconstruction of transcatheter aortic valve (TAV) geometries and other stented cardiac devices from computed tomography (CT) images is challenging, mainly associated with blooming artifacts caused by the metallic stents. In addition, bioprosthetic leaflets of TAVs are difficult to segment due to the low signal strengths of the tissues. This paper describes a method that exploits the known device geometry and uses an image registration-based reconstruction method to accurately recover the in vivo stent and leaflet geometries from patient-specific CT images. Read More

View Article and Full-Text PDF

The Protective Performance of Modern Motorcycle Helmets Under Oblique Impacts.

Ann Biomed Eng 2022 Apr 13. Epub 2022 Apr 13.

Dyson School of Design Engineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.

Motorcyclists are at high risk of head injuries, including skull fractures, focal brain injuries, intracranial bleeding and diffuse brain injuries. New helmet technologies have been developed to mitigate head injuries in motorcycle collisions, but there is limited information on their performance under commonly occurring oblique impacts. We used an oblique impact method to assess the performance of seven modern motorcycle helmets at five impact locations. Read More

View Article and Full-Text PDF

Detection of COVID-19 from CT and Chest X-ray Images Using Deep Learning Models.

Ann Biomed Eng 2022 Apr 12. Epub 2022 Apr 12.

ATMS Lab, Advanced Technologies for Medicine and Signals, ENIS, Sfax University, Sfax, Tunisia.

Coronavirus 2019 (COVID-19) is a highly transmissible and pathogenic virus caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2), which first appeared in Wuhan, China, and has since spread in the whole world. This pathology has caused a major health crisis in the world. However, the early detection of this anomaly is a key task to minimize their spread. Read More

View Article and Full-Text PDF

Controlling the Flow Separation in Heart Valves Using Vortex Generators.

Ann Biomed Eng 2022 Apr 12. Epub 2022 Apr 12.

Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA.

A comprehensive computational study is performed to investigate the effectiveness of vortex generators (VGs) applied to mechanical bi-leaflet heart valves. Co-rotating and counter-rotating VG configurations are compared to a control valve without VGs. Detailed flow fields are obtained and used to elucidate the underlying flow physics. Read More

View Article and Full-Text PDF

Effects of MitraClip Therapy on Mitral Flow Patterns and Vortex Formation: An In Vitro Study.

Ann Biomed Eng 2022 Jun 11;50(6):680-690. Epub 2022 Apr 11.

Department of Biomedical Engineering, Georgia Institute of Technology, 387 Technology Circle, Atlanta, GA, 30313, USA.

MitraClip transcatheter edge-to-edge repair is used to treat mitral regurgitation (MR). While MR is reduced, diastolic left ventricular flows are altered. An in vitro left heart simulator was used to assess a porcine mitral valve in the native, MR, and MR plus MitraClip cases. Read More

View Article and Full-Text PDF

Frequency-Based Maternal Electrocardiogram Attenuation for Fetal Electrocardiogram Analysis.

Ann Biomed Eng 2022 Apr 11. Epub 2022 Apr 11.

Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA.

Fetal electrocardiogram (ECG) waveform analysis along with cardiac time intervals (CTIs) measurements are critical for the management of high-risk pregnancies. Currently, there is no system that can consistently and accurately measure fetal ECG. In this work, we present a new automatic approach to attenuate the maternal ECG in the frequency domain and enhance it with measurable CTIs. Read More

View Article and Full-Text PDF

In Vivo Changes in Dynamic Adjacent Segment Motion 1 Year After One and Two-Level Cervical Arthrodesis.

Ann Biomed Eng 2022 Apr 9. Epub 2022 Apr 9.

Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Biomechanical cadaver testing indicates adjacent segment motion increases after one-level anterior cervical spine arthrodesis, and two-level arthrodesis exacerbates these effects. There is little in vivo evidence to support those biomechanical studies. The purpose of this study was to assess the effects of one- and two-level cervical arthrodesis on adjacent segment motion. Read More

View Article and Full-Text PDF

Biomechanical Changes on the Typical Sites of Pressure Ulcers in the Process of Turning Over from Supine Position: Theoretical Analysis, Simulation, and Experiment.

Ann Biomed Eng 2022 Jun 8;50(6):654-665. Epub 2022 Apr 8.

Beijing Key Laboratory of Advanced Manufacturing Technology, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing, 100124, China.

Pressure ulcers are mainly caused by prolonged pressure on local tissues. The current method of preventing pressure ulcers is mainly to change the patient's position by turning, so it is significant to study the biomechanics of the typical site of pressure ulcers. Based on anatomical theory, a three-dimensional model of the shoulder and hip was established, and the theoretical contact pressure between the body and the bed was calculated by force analysis. Read More

View Article and Full-Text PDF

Neck Loads During Head-First Entries into Trampoline Dismount Foam Pits: Considerations for Trampoline Park Safety.

Ann Biomed Eng 2022 Jun 5;50(6):691-702. Epub 2022 Apr 5.

Neuroscience Research Australia, Margarete Ainsworth Building, 139 Barker St, Randwick, NSW, 2031, Australia.

Serious cervical spine injuries have been documented from falls into foam pits at trampoline parks. To address the lack of evidence on how foam pits should be designed for mitigating neck injury risk, this study aimed to quantify neck loads during head-first entry into varying foam pit designs. An instrumented Hybrid III anthropomorphic test device was dropped head-first from a height of up to 1. Read More

View Article and Full-Text PDF

Patient-Specific Three-Dimensional Ultrasound Derived Computational Modeling of the Mitral Valve.

Ann Biomed Eng 2022 Apr 5. Epub 2022 Apr 5.

Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center at Emory University Hospital Midtown, 380B Northyards Blvd NW, Atlanta, GA, 30313, USA.

Several new techniques to repair the mitral valve affected by functional mitral regurgitation are in development. However, due to the heterogeneity of valve lesions between patients, predicting the outcomes of novel treatment approaches is challenging. We present a patient-specific, 3D ultrasound-derived computational model of the mitral valve for procedure planning, that faithfully mimics the pathological valve dynamics. Read More

View Article and Full-Text PDF

Non-Linear Device Head Coupling and Temporal Delays in Large Animal Acceleration Models of Traumatic Brain Injury.

Ann Biomed Eng 2022 Jun 2;50(6):728-739. Epub 2022 Apr 2.

Enroute Care Group, U.S. Army Aeromedical Research Laboratory, Fort Rucker, AL, 36362-0577, USA.

Accurate characterization of head kinematics following an external blow represents a fundamental aspect of traumatic brain injury (TBI) research. The majority of previous large animal studies have assumed an equivalent relationship between the device delivering the impulsive load and subsequent head kinematics rather than performing direct measurement (sensors or videography). The current study therefore examined factors affecting device/head coupling kinematics in an acceleration TBI model. Read More

View Article and Full-Text PDF

Determining Clinically-Viable Biomarkers for Ischaemic Stroke Through a Mechanistic and Machine Learning Approach.

Ann Biomed Eng 2022 Jun 1;50(6):740-750. Epub 2022 Apr 1.

INSIGNEO Institute for In Silico Medicine, The University of Sheffield, Sheffield, UK.

Assessment of distal cerebral perfusion after ischaemic stroke is currently only possible through expensive and time-consuming imaging procedures which require the injection of a contrast medium. Alternative approaches that could indicate earlier the impact of blood flow occlusion on distal cerebral perfusion are currently lacking. The aim of this study was to identify novel biomarkers suitable for clinical implementation using less invasive diagnostic techniques such as Transcranial Doppler (TCD). Read More

View Article and Full-Text PDF

Characterizing Musculoskeletal Tissue Mechanics Based on Shear Wave Propagation: A Systematic Review of Current Methods and Reported Measurements.

Ann Biomed Eng 2022 Mar 31. Epub 2022 Mar 31.

Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, USA.

Developing methods for the non-invasive characterization of the mechanics of musculoskeletal tissues is an ongoing research focus in biomechanics. Often, these methods use the speed of shear wave propagation to characterize tissue mechanics (e.g. Read More

View Article and Full-Text PDF

Experimental and Computational Models of Transport of Galectin-3 Through Glycosylated Matrix.

Ann Biomed Eng 2022 Jun 29;50(6):703-715. Epub 2022 Mar 29.

J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, 32611, USA.

Altered extracellular matrix (ECM) production is a hallmark of many fibroproliferative diseases, including certain cancers. The high incidence of glycan-rich components within altered ECM makes the use of glycan-binding proteins such as Galectin-3 (G3) a promising therapeutic strategy. The complexity of ECM as a rich 3D network of proteins with varied glycosylation states makes it challenging to determine the retention of glycan-binding proteins in altered ECM environments. Read More

View Article and Full-Text PDF

Effect of Assistance Using a Bilateral Robotic Knee Exoskeleton on Tibiofemoral Force Using a Neuromuscular Model.

Ann Biomed Eng 2022 Jun 27;50(6):716-727. Epub 2022 Mar 27.

Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

Tibiofemoral compression forces present during locomotion can result in high stress and risk damage to the knee. Powered assistance using a knee exoskeleton may reduce the knee load by reducing the work required by the muscles. However, the exact effect of assistance on the tibiofemoral force is unknown. Read More

View Article and Full-Text PDF

Automated Tissue Strain Calculations Using Harris Corner Detection.

Ann Biomed Eng 2022 May 25;50(5):564-574. Epub 2022 Mar 25.

Graduate Program in Acoustics, Pennsylvania State University, 201E Applied Science Building, University Park, PA, 16802, USA.

The elastic modulus, or slope of the stress-strain curve, is an important metric for evaluating tissue functionality, particularly for load-bearing tissues such as tendon. The applied force can be tracked directly from a mechanical testing system and converted to stress using the tissue cross-sectional area; however, strain can only be calculated in post-processing by tracking tissue displacement from video collected during mechanical testing. Manual tracking of Verhoeff stain lines pre-marked on the tissue is time-consuming and highly dependent upon the user. Read More

View Article and Full-Text PDF