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    3461 results match your criteria Annali dell'Istituto Superiore di SanitA  [Journal]

    1 OF 70

    Long-term services for the care and rehabilitation of people with severe acquired brain injury: a multicentre, cross-sectional study of 536 Italian families.
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):253-265
    IRCCS Santa Maria Nascente, Fondazione Don Gnocchi Onlus, Milan, Italy.
    Background: People with severe acquired brain injuries (ABIs) require complex, long-term multidisciplinary healthcare, and social welfare programmes, and their families experience social and emotional consequences that profoundly condition their quality of life.

    Objective: To investigate whether the possibility of gaining access to local rehabilitation and other services positively influences not only the quality of life of the patients but also the quality of life of their families.

    Methods: The sample consisted of 536 families of patients with severe ABIs. Read More

    Survey of health and social-health services for people with dementia: methodology of the Italian national project.
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):246-252
    Centro Nazionale Prevenzione delle Malattie e Promozione della Salute, Istituto Superiore di Sanità, Rome, Italy.
    People with dementia have special assistance needs. Worldwide problem is to ensure access to quality health services. Our study supported by the Italian Ministry of Health reports methodology features of a large survey project conducted to identify and to collect information on health and social health services for people with dementia in Italy. Read More

    Immigrants and cancer in Italy: a literature review.
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):238-245
    Registro Tumori della Romagna, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (FC), Italy - Centro di Prevenzione Oncologica, Ospedale Morgagni-Pierantoni, AUSL della Romagna, Forlì, Italy.
    Immigration is a growing flow in Italy. Also specific health needs could be imported. We focused on cancer. Read More

    Infant immunization coverage in Italy (2000-2016).
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):231-237
    Direzione Generale della Prevenzione Sanitaria, Ministero della Salute, Rome, Italy.
    Background: In Italy, national-level immunization polices are included in the National Immunization Prevention Plan (PNPV), whose latest edition - 2017-2019 PNPV - was finally approved in February 2017. Coverage rates are a key measure of immunization system performance; it can inform and support national and regional polices' implementation monitoring, as well as measure the impact of interventions aimed at increasing vaccine uptake.

    Methods: We collected, analysed and critically interpreted 2000-2016 Italian national infant immunization coverage trends, by different vaccine, target population, and by Region. Read More

    Local health rules and building regulations: a survey on local hygiene and building regulations in Italian municipalities.
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):223-230
    Dipartimento di Architettura, Ingegneria delle Costruzioni e Ambiente Costruito (ABC), Politecnico di Milano, Milan, Italy.
    Introduction: WHO has highlighted the need to strengthen the relationship between health and built environment factors, such as inappropriate housing conditions. Local Health Rules (LHRs) and Building Regulations (BRs) are tools which provide safety and building hygiene in construction practices. Currently the Italian Government is considering to establish a National Building Regulation and, related to the following purpose, this paper presents a survey on the status of adoption and updating of LHRs and BRs in Italian municipalities. Read More

    Surveillance of childhood overweight: comparison of "OKkio alla SALUTE" survey and general paediatrics data in the Province of Trento.
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):218-222
    U.O. Igiene Pubblica, Dipartimento di Prevenzione, Azienda Provinciale per i Servizi Sanitari, Trento, Italy.
    Estimates of childhood overweight and obesity for the Province of Trento provided by the 2014 "OKkio alla SALUTE" survey (Italian national surveillance system for weight and nutrition in children) were compared with estimates provided by paediatric health forms. The Province of Trento is the only region that makes use of the information gathered through these forms, which are completed by primary care paediatricians as part of the 6-year health evaluation. OKkio alla SALUTE data for children, obtained from students enrolled in the third year of primary school in 2014 (845 children aged 8-9 years), were compared with data collected at the age of 6 for cohorts born in 2006, evaluated in 2012-2013 (3101 subjects). Read More

    Molecular characterization of Neisseria gonorrhoeae on non-cultured specimens from multiple anatomic sites.
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):213-217
    Dipartimento Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy.
    Introduction: The aim of this study was to molecularly characterize Neisseria gonorrhoeae on non-cultured specimens collected from multiple anatomic sites. N. gonorrhoeae multiantigen sequence typing (NG-MAST) together with the gene sequence analysis of antimicrobial resistance (AMR) target genes were used. Read More

    Assessment of Health Literacy and validation of single-item literacy screener (SILS) in a sample of Italian people.
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):205-212
    Dipartimento di Scienze della Salute, Università degli Studi di Firenze, Florence, Italy.
    Background: Health literacy (HL) is a complex concept with multiple components; it involves the ability to effectively use and interpret texts, documents, and numbers.

    The Aims Of Our Study Were: to measure HL levels among a sample of adult Italian patients; to develop and validate the Italian version of the single-item literacy screener (SILS); to assess the diagnostic accuracy of the SILS as an indicator of limited reading ability regarding health documents, compared to the newest vital sign (NVS).

    Methods: The subjects were enrolled in emergency departments, primary care settings, and specialist departments. Read More

    Eating episode frequency and fruit and vegetable consumption among Italian university students.
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):199-204
    Istituto di Sanità Pubblica, Sezione di Igiene, Università Cattolica del Sacro Cuore, Rome, Italy.
    Objective: To analyze breakfast consumption, regularity of meals, fruit and vegetable consumption in the Italian university student population on a national level.

    Design: Descriptive analysis evaluating data taken from the Sportello Salute Giovani (SSG) questionnaire.

    Participants: 12 000 university students who self-administered a confidential survey. Read More

    Illicit drugs consumption evaluation by wastewater-based epidemiology in the urban area of Palermo city (Italy).
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):192-198
    Dipartimento di Ingegneria Civile, Ambientale, Aerospaziale, dei Materiali, Università degli Studi di Palermo, Palermo, Italy.
    Introduction: A wastewater-based epidemiology approach was performed to estimate the drug consumption in Palermo city, the fifth largest city of Italy with a population of 671 696 inhabitants, and to investigate the monthly variability of drug loads in wastewater from different areas of the city. A seven-months detection campaign was conducted at the two wastewater treatment plants of the city.

    Methods: Following a pre-treatment, 32 samples of wastewater were analyzed by liquid chromatography-tandem mass spectrometry. Read More

    P4 Medicine versus Hippocrates.
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):185-191
    Centro Nazionale Malattie Rare, Istituto Superiore di Sanità, Rome, Italy.
    Hippocrates was the first to raise awareness of medicine as a science. He asserted the body being a unified whole and emphasized the importance of preventive and predictive medicine, spurring physicians to foster patient collaboration. Recent achievements today have permitted a new approach "P4 medicine" - Predictive, Preventive, Personalized and Participatory - with the aim of depicting an individual's health history and molecular profile in determining the best medical intervention in maintaining or restoring wellbeing. Read More

    Clinical ethics and the role of clinical ethics committees: proposals for a revival. Commentary.
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):183-184
    President, Istituto Superiore di Sanità, Rome, Italy.
    The issue addressed in the paper published by the Italian National Bioethics Committee (NBC) entitled "Clinical ethics committees", is highly significant for many reasons. One of these is the fact that the ethics committees charged with assessing clinical trials have so much responsibility and such a heavy work-load that they have little time available for other tasks such as engaging directly with patients "at the bedside", as a result of which the role of committees responsible for assessing clinical cases is especially important. According to the NBC, the opinions of clinical ethics committees should be formulated jointly and are non-binding. Read More

    Sustainable public health systems for rare diseases.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):170-175
    Centro Nazionale Malattie Rare, Istituto Superiore di Sanità, Rome, Italy.
    Introduction: In the framework of the Joint Action for Rare Diseases (RD-ACTION), a specific task was defined to identify mechanisms influencing sustainability, equity and resilience of health systems for rare diseases (RDs).

    Method: Literature narrative review on health systems sustainability and resilience for RDs. Years: 2000-2015. Read More

    A case of fulminant subacute sclerosing panencephalitis presenting with acute myoclonic-astatic epilepsy.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):167-169
    Laboratorio Nazionale di Riferimento per il Morbillo e la Rosolia, Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy.
    The neurologic sequelae post-measles are less common than other complications measles-related and can lead to severe disability or death: primary measles encephalitis (PME), acute post-infectious measles encephalomyelitis (APME), measles inclusion body encephalitis (MIBE), and subacute sclerosing panencephalitis (SSPE). SSPE syndrome can affect people years from the acute measles virus infection, as result of the persistence of defective viral particles in brain cells. Clinical onset typically manifests with progressive intellectual deterioration, behavioral changes, and myoclonic jerks. Read More

    The professional quality criteria of Italian breast screening radiologists: results from a national survey comparing the programmes started in 2000-2012 versus the ones started in 1990-1999.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):163-166
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Forlì, Italy.
    Introduction: In Italy, due to increasing healthcare budget and staff shortages, the recently created regional mammography screening programmes were established under worse radiology practice quality criteria than the previously created programmes.

    Methods: Using available data from a national questionnaire survey conducted at the end of 2013 and involving 222 responder radiologists, we compared the main professional quality standards of radiologists working in the screening programmes established during the period 2000-2012 with those working in the screening programmes created from 1990 to 1999.

    Results: The former reported more years of clinical experience in breast imaging and a greater clinical mammogram reading volume than the latter. Read More

    Vaccine hesitancy: parental, professional and public responsibility.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):157-162
    President, Istituto Superiore di Sanità, Rome, Italy.
    The opposition to vaccinations is a well-known phenomenon that dates back to the Victorian age when it was self-limited by the awareness of the importance to be protected against fearsome infectious diseases. In the XX century, the mass use of vaccination has - instead - consented to eradicate or drastically reduce the burden of diseases such as smallpox and polio. These positive effects of the vaccination campaigns have blurred out, if not erased, the memory of the tragic consequences of the past's widespread diseases, leading people to underestimate the severity of the harm that vaccinations prevent. Read More

    MMR vaccine in the postpartum does not expose seronegative women to untoward effects.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):152-156
    SOC Pediatria, Ospedale Castelli, Verbania, Italy.
    Background: The aim of this study was to assess whether rubella vaccination immediately after delivery could expose seronegative women to specific untoward effects.

    Methods: 163 rubella-seronegative women received Measles-Mumps-Rubella (MMR) vaccine in the immediate postpartum period; they were evaluated at one month and at three months thereafter through telephone interviews. As controls, we matched 163 rubella-seropositive women, who might experience similar symptoms for any reason in the same timeframe. Read More

    Health-promotion theories in nutritional interventions for community-dwelling older adults: a systematic review.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):146-151
    Unità di Ricerca in Scienze Infermieristiche, Facoltà Dipartimentale di Medicina, Università Campus Bio-Medico di Roma, Rome, Italy.
    Objective: To identify theories applied in interventions promoting healthy nutrition among community-dwelling older adults and determine the efficacy of theories in changing knowledge, attitudes, and behaviors.

    Material And Methods: The PubMed, PsycINFO, Embase, and ERIC databases were searched for English articles from January 1990 to December 2015. Mono or multicomponent randomized controlled trial studies were included, whereas research on nutritional interventions related to acute or chronic diseases were excluded. Read More

    Pes planus and pes cavus in Southern Italy: a 5 years study.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):142-145
    ASL Foggia, Foggia, Italy.
    Introduction: Baropodometrical digital techniques map the pressures exerted on the foot plant during both static and dynamic loadings. The study of the distribution of such pressures makes it possible to evaluate the postural and locomotory biomechanics together with its pathological variations.

    Methods: From January 2011 to August 2016 we conducted a cross sectional study in order to diagnose flatfoot and hollowfoot through the baropodometric analysis, and collecting additional information such as gender and the age. Read More

    Trend and variability in open and laparoscopic hysterectomies for patients with benign disease: a retrospective cohort study.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):135-141
    Laboratorio di Sanità Pubblica, Dipartimento di Medicina Molecolare, Università degli Studi di Padova, Padua, Italy.
    Aim: The aim of the present analysis on a regional hospital database was to ascertain the variability and 5-year trends of hysterectomy rates and the different surgical approaches used.

    Methods: A retrospective cohort study was conducted in Veneto Region (North-East Italy), based on administrative data collected in 6 years, from 2009 to 2014.

    Results: Our study showed an overall decline in the hospitalization rates for hysterectomy from 197. Read More

    Micronized palmitoylethanolamide/trans-polydatin treatment of endometriosis-related pain: a meta-analysis.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):125-134
    Scuola di Farmacia, Università di Camerino, Camerino, Italy.
    Aim: To demonstrate clinical effectiveness of micronized palmitoylethanolamide-trans-polydatin combination in reducing endometriotic chronic pelvic pain. Other endometriotic-pains were also assessed.

    Methods: Systematic reviews of PubMed, SCIELO, Scopus, and AJOL. Read More

    Do Italian pregnant women use periconceptional folate supplementation?
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):118-124
    Centro Nazionale di Prevenzione delle Malattie e Promozione della Salute, Istituto Superiore di Sanità, Rome, Italy.
    Introduction: Deficiency of folic acid (FA) has been identified as a risk factor for neural tube defects (NTDs) as well as other congenital anomalies. Thus, periconceptional folate supplementation is recommended for all women planning to get pregnant.

    Methods: We conducted a KAP (knowledge, attitude, practice) survey to investigate the use of FA and its appropriateness. Read More

    Mortality of populations residing in geothermal areas of Tuscany during the period 2003-2012.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):108-117
    Unità di Epidemiologia Ambientale e Registri di Patologia, Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa, Italy.
    Introduction: The limited scientific knowledge on the relationship between exposure and health effects in relation to geothermal activity motivated an epidemiologic investigation of Tuscan geothermal area.

    Aim: This study aims at describing mortality of populations living in Tuscan municipalities in the period 2003-2012.

    Method: Sixteen municipalities were included in the study area: eight in the northern and eight in the southern area. Read More

    A harmonized and efficient clinical research environment would benefit patients and enhance European competitiveness. Commentary.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):104-107
    Dipartimento di Oncologia Sperimentale, Istituto Europeo di Oncologia, Milan, Italy.
    The forthcoming implementation of the European Clinical Trial Regulation (Regulation (EU) No. 536/2014), which is expected to facilitate the conduct of clinical trials across the European Union, will require National Authorities to create the best conditions for the implementation of the new Regulation through national guidelines, so that sponsors may reconsider Europe as a prime location for planning clinical trials. During a meeting titled "Innovation in Clinical Research", an expert panel discussed potential local advances fostering competitiveness of European clinical research with representatives of the pharmaceutical industry, patient organisations and Italian regulatory agency in view of the forthcoming implementation of (EU) No. Read More

    Pertussis in infants and the resurgence of a vaccine preventable disease: what to do? Commentary.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):100-103
    Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy.
    Pertussis or whooping cough remains one of the most poorly controlled vaccine-preventable diseases across the world. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In the last decades, changes in pertussis epidemiology have been noted, likely related to the introduction of acellular pertussis vaccines. Read More

    The emerging role of the human bone marrow as a privileged developmental niche for the transmission stages of the malaria parasite Plasmodium falciparum. Commentary.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):96-99
    Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy.
    The spread of malaria relies on the ability of the Plasmodium parasites to be transmitted from infected individuals to the Anopheles mosquito vectors. Recent work on the most lethal of the malaria parasites, Plasmodium falciparum, identified the infected human bone marrow as a preferential site for the localization and maturation of the parasite transmission stages, the gametocytes. These findings unveil a complex host parasite interplay and an unsuspected role of the bone marrow microenvironment in the successful transmission of the malaria parasite and have major implications in developing and targeting future interventions to block the transmission of P. Read More

    Patient-physician alliance: from Hippocrates to Post-Genomic Era. Commentary.
    Ann Ist Super Sanita 2017 Apr-Jun;53(2):93-95
    Centro Nazionale Malattie Rare, Istituto Superiore di Sanità, Rome, Italy.
    Patients need clinical competence, appropriate diagnosis and therapies in overcoming their disease. Yet this is insufficient. The illness experience tends to frighten people and the resulting emotional aspects could become relevant factors in coping with a sickness and disability. Read More

    Educational action in the rehabilitation of severe acquired brain injuries: the role of self-awareness.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):82-85
    IRCCS, Fondazione Santa Lucia, Ospedale di Riabilitazione, Rome, Italy.
    Severe acquired brain injuries (ABI) cause a range of short-or long-term limitations in physical and neuropsychological abilities. The aim of rehabilitation is to promote the harmonious development of the individual through collaboration between medical and educational sciences, involved in the educability of the whole person, in which the aim is not only functional recovery but also social-reintegration. This "functional synergy" permits the development of the person, and establishes an indissoluble link between functions and attitudes, thus allowing the achievement of the greater possible autonomy. Read More

    Association of non-alcoholic fatty liver disease and cardiometabolic risk factors with early atherosclerosis in an adult population in Southern Italy.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):77-81
    Unità di Medicina, Gastroenterologia e Epatologia, Dipartimento di Scienze della Salute, Ospedale San Paolo, Università degli Studi di Milano, Milan, Italy.
    Aim: The prevalence of risk factors for cardiovascular and metabolic diseases was investigated in an adult population of the city of Cittanova, Southern Italy.

    Methods: The study was conducted among 992 randomly selected adults aged 18-75 years, between April 2009 and January 2011.

    Results: Prevalence rates of non-alcoholic fatty liver disease (NAFLD), overweight, obesity, and metabolic syndrome (MS) were 24. Read More

    Appropriateness and efficacy of Spa therapy for musculoskeletal disorders. A Delphi method consensus initiative among experts in Italy.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):70-76
    Dipartimento di Medicina Fisica e Riabilitativa, Sapienza Università di Roma, Rome, Italy.
    Objective: The aim of the study was to identify the main aspects concerning appropriateness and efficacy of Spa therapy for musculoskeletal pathologies.

    Methods: A committee of 8 experts from Italian universities, public hospitals, territorial services, research institutes and patient associations was set up. Clinicians from Italian medical centers specialized in rheumatology, rehabilitation and thermal medicine took part in a Delphi process aimed at obtaining consensus statements among the participants. Read More

    The Italian reference sites of the European innovation partnership on active and healthy ageing: Progetto Mattone Internazionale as an enabling factor.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):60-69
    Dipartimento di Epidemiologia del Servizio Sanitario Regionale, Regione Lazio, Rome, Italy.
    Background: Ageing population implies an increasing demand for health care services and resources, unsustainable according to current previsions. The European Commission is tackling this challenge throughout initiatives such as the European Innovation Partnership on Active and Healthy Ageing (EIP-AHA), where all the efforts are aligned to the common goal of adding two active and healthy years to the life of European Union (EU) citizens.

    Method: We presented the collaborative efforts of Italian Reference Site Collaborative Network 2012-2015. Read More

    Association between serum vitamin D and metabolic syndrome in middle-aged and older adults and role of supplementation therapy with vitamin D.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):54-59
    Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Rome, Italy.
    Objectives: To evaluate i) the correlation between vitamin D (vit. D) serum concentrations and metabolic syndrome (MetS); ii) the efficacy of 6 months supplementation therapy with vit. D. Read More

    Hospital efficiency: how to spend less maintaining quality?
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):46-53
    President, Istituto Superiore di Sanità, Rome, Italy.
    Introduction: The recent global economic crisis is pushing governments worldwide to obtain a more explicit and urgent rationing of resources. The purpose of this study is to provide, through Data Envelopment Analysis (DEA), a methodological framework useful for investigating technical efficiency of hospital care.

    Methods: To validate such framework, we compared 50 Italian public hospital trusts (AOs) to identify relative efficient using inputs and outputs from national databases. Read More

    Risk adjusted mortality after hip replacement surgery: a retrospective study.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):40-45
    Dipartimento di Medicina Molecolare e dello Sviluppo, Università degli Studi di Siena, Siena, Italy.
    Introduction: Hip replacement (HR) operations are increasing. Short term mortality is an indicator of quality; few studies include risk adjustment models to predict HR outcomes. We evaluated in-hospital and 30-day mortality in hospitalized patients for HR and compared the performance of two risk adjustment algorithms. Read More

    Illicit drugs in Emergency Department patients injured in road traffic accidents.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):35-39
    Laboratorio di Tossicologia Analitica,Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
    Urine and blood samples from 1730 drivers involved in road accidents (July 2012 - December 2015) were analyzed for the evaluation of driving under influence of drug of abuse according to the Lombardia Region guideline. The 22.5% (95% CI 20. Read More

    Molecular characterization of Babesia and Theileria species in ticks collected in the outskirt of Monte Romano, Lazio Region, Central Italy.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):30-34
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Rome, Italy.
    Background: In 2012-2013, an investigation was carried out in the Viterbo province, Lazio region, on ticks and tick-borne Apicomplexan protozoa of the Babesia and Theileria genera. This followed the reporting of high density of ticks by soldiers operating in a military shooting range, and the signaling by owners and local veterinary authorities of several cases of babesiosis among cattle.

    Methods: A total of 422 ticks were collected from 35 heads, whereas 96 ticks were collected by dragging. Read More

    Uterus transplants and their ethical implications.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):25-29
    Dipartimento di Chimica, Biologia e Biotecnologie, Università degli Studi di Perugia, Perugia, Italy.
    Early experiments in womb transplants have increased interest in the possibility of performing this procedure in women who have no womb, usually for congenital reasons. The present article describes past experiments and summarises the most relevant reference documents before indicating the key ethical implications involved in womb transplants. Read More

    The product of the human AHI-1 (Abelson helper integration site) gene: experimental in vitro data point to its involvement in tumor cell invasion.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):17-24
    Centro Nazionale per la Ricerca e la Valutazione Preclinica e Clinica dei Farmaci, Istituto Superiore di Sanità, Rome, Italy.
    Introduction: Each of the steps involved in invasion of tumors requires specific molecular program in which the modulation of adhesive and migratory properties of disseminating cells plays an essential role. The improvement in the knowledge of these mechanisms can lead to discovery of new target candidates in drug development. In this study we focused attention on the product of the human AHI-1 (Abelson helper integration site) gene Jouberin (Jbn). Read More

    Do I need training in public health ethics? A survey on Italian residents' beliefs, knowledge and curricula.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):9-16
    Istituto di Igiene, Dipartimento di Medicina Molecolare, Università degli Studi di Padova, Padua, Italy.
    Introduction: Ethics is needed to support the decision-making process in public health and to face moral issues during practice. However, professionals are often not adequately trained.

    Objectives: In 2015, the National Conference of Public Health Medical Residents of the Italian Society of Public Health started the "Public Health Ethics" workgroup to evaluate how the Italian Schools of Public Health train their residents in ethics, and which are residents' beliefs, knowledge and attitudes about public health ethics. Read More

    Research on biological materials of human origin. Jurists and scientists face to face. Commentary.
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):6-8
    President, Istituto Superiore di Sanità, Rome, Italy.
    On 3rd October 2016 a convention was held in the Aldo Moro room of the Chamber of Deputies on "Research on biological materials of human origin. Jurists and scientists face to face". The convention was organised by the Bioethics Unit of the Istituto Superiore di Sanità (ISS, Italian National Institute of Health) in conjunction with the Italian Academy of the Internet Code (IAIC) and the Fondazione Centro di Iniziativa Giuridica Piero Calamandrei. Read More

    Drug-resistant tuberculosis in Naples, 2008-2013.
    Ann Ist Super Sanita 2016 Oct-Dec;52(4):603-607
    Laboratorio di Microbiologia e Virologia, Ospedali dei Colli, Naples, Italy.
    Background: Drug-resistant tuberculosis (TB) is a serious threat in industrialized countries, but information from Southern Italy is lacking. Here, we present the results of a retrospective study of TB cases diagnosed in 2008-2013 in Naples, the largest city in Southern Italy.

    Methods: Six hundred ninety Mycobacterium tuberculosis strains were isolated at the Ospedali dei Colli of Naples, and resistance to first-line and second-line drugs was determined. Read More

    Teleretinography into diabetes integrated care: an Italian experience.
    Ann Ist Super Sanita 2016 Oct-Dec;52(4):598-602
    UOC Endocrinologia e Malattie del Metabolismo, Centro di Diabetologia, AUSL Pescara, Italy.
    Introduction: Integrated care, by allowing information exchange among health professionals, improves outcomes and favours a reduction in hospital admission in diabetes. Retinal complications can be sight-threatening, and diabetic patients often miss the suggested yearly clinical examination.

    Methods: Teleretinography can be easily performed in patients attending Diabetes Clinics: images are sent to a remote ophthalmologist, grading and instructions are received and forwarded to General Practitioners by a dedicated software. Read More

    Smallpox as an actual biothreat: lessons learned from its outbreak in ex-Yugoslavia in 1972.
    Ann Ist Super Sanita 2016 Oct-Dec;52(4):587-597
    Faculty of Medicine, University of Montenegro, Podgorica, Montenegro.
    Variola (smallpox) virus is classified as class A of potential biological weapons, due to its microbiological, genetic, antigenic and epidemiological characteristics. The potential danger is more real because vaccination against smallpox has stopped since disease eradication in 1979. That is why we want to share our unique, rich experience and acquired knowledge in the fight against this highly contagious and deadly disease during the smallpox outbreak in ex-Yugoslavia in 1972. Read More

    The relationship between medical ethics and the legal system in Italy: food for thought.
    Ann Ist Super Sanita 2016 Oct-Dec;52(4):582-586
    President, Istituto Superiore di Sanità, Rome, Italy.
    Relations between ethics in general - and medical ethics in particular - and legal systems are complex and have been extensively examined in the literature. The topic is important not only for ethicists and jurists, but also for members of the public, who benefit from the services offered by the professions. While the Italian Institute of Health does not claim to propose new avenues for exploration of the relations between ethics and legal systems, it offers some food for thought in the ongoing debate. Read More

    Adverse reproductive outcomes associated with exposure to a municipal solid waste incinerator.
    Ann Ist Super Sanita 2016 Oct-Dec;52(4):576-581
    Unità di Epidemiologia Ambientale e Registri di Patologia, Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa, Italy.
    Introduction: The association between reproductive health outcomes and exposure to municipal solid waste incinerators (MSWIs) is inconclusive. This study investigates the association between exposure to a MSWI and various reproductive outcomes (preterm birth, low birth weight, small for gestational age, and sex ratio), taking into account other sources of pollution (industrial plants, highway, major roads with high traffic flows) and maternal factors, including the socioeconomic status.

    Methods: PM10 concentration maps were used for the exposure assessment to the MSWI and to other sources of pollution in the study area. Read More

    Melanoma prevention in children: knowledge, attitudes and behaviors of pediatricians in Italy.
    Ann Ist Super Sanita 2016 Oct-Dec;52(4):570-575
    Dipartimento di Medicina Sperimentale, Seconda Università degli Studi di Napoli, Naples, Italy.
    Introduction: The aims of this study were to assess the levels of knowledge, attitudes and behaviors of pediatricians about melanoma and to estimate any variables associated with this outcome of interest.

    Materials And Methods: A cross-sectional survey was conducted on a sample of pediatricians using a questionnaire sent by postal mail.

    Results: 40. Read More

    Continuous professional development and health sector governance in Egypt.
    Ann Ist Super Sanita 2016 Oct-Dec;52(4):565-569
    Medical Research Institute, Alexandria University, Alexandria, Egypt.
    The Authors present the main activities and results of a Project financed by the Italian-Egyptian Debt Swap Agreement (IEDDS/DS) of the Italian Development Cooperation to repay public debt. The Health Governance Project operated within the Egyptian health reform paradigm and aimed at producing evidence for policy makers to direct and reorient the health sector and service management. It developed along three phases: i) preparatory training of trainers, ii) training in health governance according to modern andragogic methods, such as problem-based learning, iii) following implementation. Read More

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