J Neurosci 2021 12 29;41(49):10080-10090. Epub 2021 Oct 29.
Department of Psychology, University of Maryland, College Park, Maryland 20742
Accumulating evidence in the past decade implicates histone-modifying enzymes, such as class I histone deacetylases (HDACs), in learning and memory and, recently, habit formation. However, it is unclear whether HDACs play roles in complex cognitive function. To address this issue, we examined the role of dorsal striatal HDAC5, a class II HDAC, in reward-guided decision-making and associated neural encoding in rats. Read More