3,609 results match your criteria Annali Dell Istituto Superiore Di Sanita[Journal]


Identification of two novel LDLR variants by Next Generation Sequencing.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):122-127

Unità di Diagnostica Molecolare e Genomica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Introduction: Familial hypercholesterolemia (FH) is an autosomal dominant inherited disease characterized by elevated plasma low-density lipoprotein cholesterol (LDL-C). Targeted Next Generation Sequencing (NGS) is a new opportunity to expand the existing pathogenic variants (PVs) spectrum associated to FH. Our aim was to report a diagnostic NGS-based approach to detect variants associated to FH. Read More

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http://dx.doi.org/10.4415/ANN_20_01_17DOI Listing
April 2020
0.773 Impact Factor

Application of effect-based methods (EBMs) in a river basin: a preliminary study in Central Italy.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):114-121

Unità Ecosistemi e Salute, Dipartimento Ambiente e Salute, Istituto Superiore di Sanità, Rome, Italy.

Introduction: Effect-based methods (EBMs), i.e. in vitro and in vivo bioassays, represent innovative tools for the effect detection of environmental chemical pollutants on living organisms. Read More

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http://dx.doi.org/10.4415/ANN_20_01_16DOI Listing

Social cognition deficit and genetic vulnerability to schizophrenia in 22q11 deletion syndrome.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):107-113

Dipartimento di Neuroscienze Umane, Sapienza Università di Roma, Rome, Italy.

Introduction: 22q11.2 microdeletion syndrome (22q11DS) is associated with a 25% risk of psychotic onset.

Materials And Methods: The sample consist of 120 subjects: 39 schizophrenics (SCZ); 20 siblings of schizophrenic patients (SIB); 34 22q11DS non-psychotic patients (DEL); 17 22q11DS psychotic patients (DEL_scz); 30 control subjects (CS). Read More

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http://dx.doi.org/10.4415/ANN_20_01_15DOI Listing

Effects of a practice-focused nutrition intervention in Hungarian adolescents.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):99-106

Hungarian School Sport Federation (Magyar Diáksport Szövetség), Budapest, Hungary.

Introduction: This work evaluated the impact of a nutrition intervention in school children of 6th and 7th grade and assessed whether changes persisted after the summer break.

Materials And Methods: Eight classes of Hungarian adolescents (45% boys; 12.6 ± 0. Read More

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http://dx.doi.org/10.4415/ANN_20_01_14DOI Listing

Prevalence and correlates of food insecurity among children in high-income European countries. A systematic review.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):90-98

Sezione di Igiene, Dipartimento Universitario Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, Rome, Italy - Dipartimento di Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.

Background: In Europe, there is not routinely collected data on children's food insecurity. Indirect data show that food insecurity is on the rise in Europe, which may have a great impact on children's health.

Methods: Considering that, we systematically reviewed any evidence coming from European countries in the last 10 years that reported the prevalence and correlates of food insecurity among children, intending to serve as a starting point for policymakers and guidelines. Read More

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http://dx.doi.org/10.4415/ANN_20_01_13DOI Listing

Evolution of Italian laws banning trafficking, use and abuse of psychotropic drugs.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):76-89

Centro Nazionale Dipendenze e Doping, Istituto Superiore di Sanità, Rome, Italy.

The penalty system implemented by Italian law still represents a barrier against psychoactive drugs and drug addiction, especially at a time when the age of first consumption has considerably dropped. Presidential Decree n. 309 of October 9, 1990 entitled "Consolidation of the laws governing drugs and psychotropic substances, the prevention, treatment and rehabilitation of drug addicts", and referred to as Presidential Decree 309/90, is the reference text for the cultivation, production, trade and use of narcotics and other psychoactive substances in Italy. Read More

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http://dx.doi.org/10.4415/ANN_20_01_12DOI Listing

Malaria in pediatric age in the Piedmont Region.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):72-75

Dipartimento Materno-Infantile, Ospedale Castelli, Verbania, Italy.

Introduction: Pediatric malaria, even in countries considered as free as Italy, is an important problem of public health because children have a high variability of the clinical picture. The objective of this brief note is to determine the incidence of pediatric malaria in the Piedmont Region during the period 1989-2015.

Materials And Methods: All cases of pediatric malaria notified were considered thanks to the regional information flow over the period 1989-2015. Read More

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http://dx.doi.org/10.4415/ANN_20_01_11DOI Listing

Effectiveness of psycho-educational intervention to promote mental health focused on emotional intelligence in middle-school.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):66-71

Centro di Riferimento Scienze Comportamentali e Salute Mentale, Istituto Superiore di Sanità, Rome, Italy.

Purpose: The specific "outcome-oriented" pattern of the emotional intelligence (EI) should be considered of capital importance for teenagers in order to promote mental health. Nevertheless it is rarely evaluated because a specific tool, useful for routinely use, is not available. In this paper the authors describe the effectiveness of a new approach of public health to improve the EI "outcome-oriented", by a specific index. Read More

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http://dx.doi.org/10.4415/ANN_20_01_10DOI Listing

Long-term consequences in survivors of critical illness. Analysis of incidence and risk factors.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):59-65

Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale, Novara, Italy.

Aim: This study investigates the incidence of long-term consequences in survivors of critical illness 6 months after ICU care. A retrospective analysis of the risk factors was also completed.

Methods: A mixed-method design was used. Read More

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http://dx.doi.org/10.4415/ANN_20_01_09DOI Listing

Syringomyelia and Chiari Syndrome Registry: advances in epidemiology, clinical phenotypes and natural history based on a North Western Italy cohort.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):48-58

Centro Nazionale Malattie Rare, Istituto Superiore di Sanità, Rome, Italy.

Background: Syringomyelia and Chiari Syndrome are classified as rare diseases, but current known occurrence in Europe is missing. The increased ability to diagnose these pathologies by magnetic resonance imaging and its widespread availability has led to an increase of reported cases, often asymptomatic, with the need to standardize definitions, diagnostic criteria and treatments.

Aims: We present shared Interregional Recommendations developed with the primary aim to estimate Syringomyelia and Chiari Syndrome prevalence and incidence in North Western Italy, with special reference to symptomatic forms. Read More

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http://dx.doi.org/10.4415/ANN_20_01_08DOI Listing

Rehabilitation strategies for low anterior resection syndrome. A systematic review.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):38-47

Policlinico Universitario, Padua, Italy.

Objective: To summarize the evidence in the literature about rehabilitative treatments that reduce low anterior resection syndrome (LARS) symptoms in patients who underwent surgery for colorectal cancer.

Methods: We have search in PubMed, Cochrane Central Register of Controlled Trials, Cumulative Index of Nursing and Allied Health and Scopus databases. Studies selected were limited to those including only patient undergone low rectal resection with sphincter preservation and with pre-post assessment with a LARS score. Read More

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http://dx.doi.org/10.4415/ANN_20_01_07DOI Listing

HIV prevalence among adults in Rome: results of the MeDi (Measuring health Disparities in HIV prevention) survey. Part 2.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):30-37

Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy.

Background: In Italy, out of 60 millions of inhabitants, 3000 (2700-4000) new HIV infections are estimated each year. As combined antiretroviral therapy (ART) prolongs life for HIV sufferers, the prevalence of HIV-infection is likely to increase over time. Few studies have assessed factors associated with being HIV positive in people accessing public outpatient clinics and, in particular, the influence of socio-economic circumstances on HIV prevalence. Read More

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http://dx.doi.org/10.4415/ANN_20_01_06DOI Listing

Prevalence and attitudes to HIV testing among adults visiting public outpatient clinics in Rome: results of the MeDi (Measuring health Disparities in HIV prevention) survey. Part 1.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):19-29

Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy.

Background: It is estimated that, in Italy, 12 000-18 000 (11-13% of 130 000) HIV-infected subjects are not aware of their serostatus. People in this condition may visit the healthcare system multiple times without being diagnosed. If tested on one of these occasions, they could modify their high-risk behaviours and benefit from treatment, factors that reduce HIV transmission. Read More

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http://dx.doi.org/10.4415/ANN_20_01_05DOI Listing

Additive manufacturing of reconstruction devices for maxillofacial surgery: design and accuracy assessment of a mandibular plate prototype.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):10-18

Composite Materials and Mechanics Laboratory, Department of Mechanical and Aerospace Engineering, Tandon School of Engineering, New York University, Brooklyn, NY, USA.

Additive manufacturing (AM) presents unique opportunities for medical applications and in particular in maxillofacial surgery for developing patient specific implants. The quality assessment of additive manufactured products is an essential aspect for the real introduction in health services. In this framework, the purpose of the present study is to investigate the possibility of developing prototypes of mandibular plates as preoperative surgical planning models, by verification of design, analysis of internal structure integrity and evaluation of the effects of variables involved in AM processes. Read More

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http://dx.doi.org/10.4415/ANN_20_01_04DOI Listing
April 2020
0.773 Impact Factor

Epidemiological research as a driver of prevention: the Sibaté study. Commentary.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):6-9

Dipartimento Ambiente e Salute, Istituto Superiore di Sanità, Rome, Italy.

Although asbestos exposure and risks can be prevented, only five countries in Latin America have banned asbestos, including Colombia. Beginning in 2011, a collaboration between the Istituto Superiore di Sanità in Italy and Universidad de los Andes in Colombia was established, bringing together relevant expertise aiming to improve our understanding of the asbestos problem. An important result of this collaboration was a recently published study conducted in Sibaté, Colombia, a municipality where an asbestos-cement facility has operated since 1942. Read More

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http://dx.doi.org/10.4415/ANN_20_01_03DOI Listing

Why research in medicine needs a step back? Editorial.

Authors:
Stefano Fais

Ann Ist Super Sanita 2020 Jan-Mar;56(1):3-5

Dipartimento di Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.4415/ANN_20_01_02DOI Listing

Priority coding for scheduling pain medication consultations: a simple tool supporting both efficient allocation and sustainability of use of resources. Letter.

Ann Ist Super Sanita 2020 Jan-Mar;56(1):1-2

Dipartimento di Anestesia, Ospedale Papa Giovanni XXIII, Monastier (TV), Italy.

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http://dx.doi.org/10.4415/ANN_20_01_01DOI Listing

Refinement techniques in non-human primate neuroscientific research.

Authors:
Luca Bonini

Ann Ist Super Sanita 2019 Oct-Dec;55(4):408-412

Dipartimento di Medicina e Chirurgia, Università degli Studi di Parma, Parma, Italy.

Non-human primates (NHP) are widely considered an essential model for biomedical research because of their close genetic, anatomo-functional and cognitive similarities to humans. These same reasons also raise particular ethical concerns for the unavoidable harm caused to these animals, in particular to those involved in neuroscientific studies. Besides reducing the number of animals needed to the absolute minimum, it is therefore essential to implement procedures allowing, at the same time, to minimize the harm to the animals and maximize the quality and ecological validity of the data. Read More

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http://dx.doi.org/10.4415/ANN_19_04_18DOI Listing

Considering the microbiota to achieve reduction in the numbers of animals used in scientific studies.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):405-407

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.

Elimination of pathogens by laboratory rodent commercial vendors has substantially improved standardized conditions as well as laboratory animal welfare. However, pathogens are also important for basic activation and functioning of the immune system with consequential influences on the symbiotic bacteria composition in the individual microbiota. One of the reasons for failures of translating results from preclinical research to the clinical phase in some studies could be due to unintentional selection processes. Read More

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http://dx.doi.org/10.4415/ANN_19_04_17DOI Listing

The usefulness of integrated strategy approaches in replacing animal experimentation.

Authors:
Chantra Eskes

Ann Ist Super Sanita 2019 Oct-Dec;55(4):400-404

Swiss 3R Competence Centre, Bern, Switzerland.

It is currently well accepted that in general, more than one method is necessary to allow the full replacement of an animal experimentation. These so called partial replacement methods can be used within integrated strategy approaches that combine different methods and information sources. A number of integrated strategy approaches were implemented within recent years in different areas of safety and regulatory toxicology. Read More

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http://dx.doi.org/10.4415/ANN_19_04_16DOI Listing

The 3R principle: 60 years taken well. Preface.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):398-399

Centro di Riferimento Scienze Comportamentali e Salute Mentale, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.4415/ANN_19_04_15DOI Listing

Resilience actions to counteract the effects of climate change and health emergencies in cities: the role of artificial neural networks.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):392-397

Formerly at Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Rome, Italy.

Both the World Health Organization (WHO) with its 2015 "Climate and Health Country Profile Project" and the Istituto Superiore di Sanità (ISS) with its 2018 "Health and Climate Change", agree on the emergency generated by the climate change and concerning health problems. The mitigation strategy suggested by the Intergovernmental Panel On Climate Change (IPCC) against greenhouse gas emissions and their effects on climate change, has not yet yielded the desired results. It is therefore necessary to focus on adaptation strategies, to immediately counter the effects of climate change (CC) on most vulnerable people and environments, by increasing their resilience through local interventions and targeted resilience actions. Read More

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http://dx.doi.org/10.4415/ANN_19_04_14DOI Listing

Measles and rubella in Italy, e-learning course for health care workers.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):386-391

Laboratorio Nazionale di Riferimento per il Morbillo e la Rosolia, Istituto Superiore di Sanità, Rome, Italy.

Introduction: Since 2003, strategic plans for the elimination of measles and congenital rubella have been adopted in the World Health Organization European Region. In Italy, a network of reference laboratories for measles and rubella (MoRoNet) has been recently implemented to ensure high-quality laboratory investigation for the confirmation of cases and outbreaks. Training among health care workers (HCWs) is one of the tasks of MoRoNet and an e-learning course was produced to improve the knowledge on international and national elimination plans and laboratory surveillance for measles and rubella. Read More

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http://dx.doi.org/10.4415/ANN_19_04_13DOI Listing

Use of probiotics in medical devices applied to some common pathologies.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):380-385

Organismo Notificato 0373, Unità Operativa Dispositivi Medici, Istituto Superiore di Sanità, Rome, Italy.

Probiotics, defined as "living microorganisms that, whether ingested in useful amount, may have beneficial effects on human body", are widely used in various products for human use, such as dietary supplements, medical devices and pharmaceutical products. The European Directive on medical devices (MDs) (DDM 93/42), also includes those MDs containing live microorganisms, particularly probiotics, that may have various destinations of use, including that of assisting the therapy of several human pathologies. In this brief note we analyzed the use of probiotics in MDs and how probiotics administration could represent one of the new frontiers of scientific research on the prevention and treatment of various diseases. Read More

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http://dx.doi.org/10.4415/ANN_19_04_12DOI Listing

Understanding mechanisms of cancer initiation and development supports the need for an implementation of primary and secondary cancer prevention.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):371-379

Dipartimento oncologia e medicina molecolare, Istituto Superiore di Sanità, Rome, Italy.

The burden of cancer is increasing worldwide, with a continuous rise of the annual total cases. Although mortality rates due to cancer are declining in developed countries, the total number of cancer deaths continues to rise due to the increase in the number of aged people. Three main causes of cancer have been described, represented by environmental factors, hereditary factors and random factors related to defects originated during cell replication. Read More

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http://dx.doi.org/10.4415/ANN_19_04_11DOI Listing

The way to move beyond the numbers: the lesson learnt from the Italian Obstetric Surveillance System.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):363-370

Centro Nazionale per la Prevenzione delle Malattie e la Promozione della Salute, Istituto Superiore di Sanità, Rome, Italy.

Objective: To describe the Italian Obstetric Surveillance System (ItOSS) investigating maternal death through incident case reporting and confidential enquiries.

Methods: All maternal deaths occurred in any public and private health facility in 8 Italian regions covering 73% of national births have been notified to the ItOSS. Every incident case is confidentially reviewed to assess quality of care and establish the cause and avoidability of the death. Read More

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http://dx.doi.org/10.4415/ANN_19_04_10DOI Listing

A web-based tumor registration system for a regional Canine Cancer Registry in Umbria, central Italy.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):357-362

Prevenzione, Sanità Veterinaria e Sicurezza Alimentare, Regione Umbria, Perugia, Italy.

The Umbria Canine Cancer Registry (CCR) is a web-based platform for cancer registration set up in order to estimate the incidence of spontaneous tumors. It is an integral part of the regional canine demographic registry in which veterinary practitioners and pathologists interact. Veterinary pathologists perform double-blind comparisons and classify neoplasms in an automated classification process using the WHO criteria for canine neoplasms and the ICD-O tumor topographical and morphological keys. Read More

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http://dx.doi.org/10.4415/ANN_19_04_09DOI Listing

Blood transfusions and adverse acute events: a retrospective study from 214 transfusion-dependent pediatric patients comparing transfused blood components by apheresis or by whole blood.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):351-356

Dipartimento di Scienze Cliniche e Chirurgiche Avanzate, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.

Introduction: Blood transfusion is a lifesaving procedure for patients affected by hematological diseases or hemorrhage risk.

Aim: This retrospective study was aimed to evaluate clinical safety of pediatric transfusions by comparing the frequency of adverse events caused by apheretic blood components vs whole blood.

Methods: From 2011 to 2015, 214 patients (blood malignancy patients, n = 144 and thalassemic patients, n = 70) received 12 531 units of blood components. Read More

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http://dx.doi.org/10.4415/ANN_19_04_08DOI Listing

Cancer incidence and congenital anomalies evaluation in the contaminated sites of Sesto San Giovanni - the SENTIERI Project.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):345-350

UOC Unità di Epidemiologia, ATS della Città Metropolitana di Milano, Milan, Italy.

The Italian Institute for Environmental Protection and Research defines national priority contaminated sites (NPCSs) as land where hazardous substances are likely to pose a risk to human health. SENTIERI was the first national project evaluating the health status of residents in NPCSs. We have extended, for the site of Sesto San Giovanni, the evaluation to cancer incidence and congenital anomalies (CAs). Read More

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http://dx.doi.org/10.4415/ANN_19_04_07DOI Listing

Ketamine abusers referring to emergency departments in northern Italy: a cross- sectional study.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):338-344

Osservatorio Epidemiologico Metropolitano Dipendenze Patologiche, DSM-DP, Azienda USL Bologna, Bologna, Italy.

Introduction: Ketamine is an essential medicine used as an anesthetic in low and middle-income countries and in veterinary medicine. Recreational use is widespread throughout the world, especially owing to its lower price compared to other substances. In Western countries its use has been mainly linked to subpopulations of young people who use drugs recreationally. Read More

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http://dx.doi.org/10.4415/ANN_19_04_06DOI Listing

Effects of short-term aerobic exercise in a mouse model of Niemann-Pick type C disease on synaptic and muscle plasticity.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):330-337

Centro Nazionale per le Malattie Rare, Istituto Superiore di Sanità, Rome, Italy.

Background: Physical exercise can reduce the risk of developing chronic diseases and slow the onset of neurodegenerative diseases. Since it has not been assessed which kind of training protocol might positively modulate both synaptic and muscular plasticity in neurodegenerative diseases, we studied in a mouse model of Niemann Pick type C disease, a model of minimal Alzheimer's Disease, the effect of a short term protocol.

Methods: We evaluated the effect of a short term, aerobic uniform exercise training on synaptic and muscle plasticity in three different mice groups: WT controls, NPC1+/- and NPC1-/- animals. Read More

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http://dx.doi.org/10.4415/ANN_19_04_05DOI Listing

Health and Climate Change: science calls for global action.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):323-329

Centro Nazionale Salute Globale, Istituto Superiore di Sanità, Rome, Italy.

Climate changes affect social and environmental health determinants such as clean air, ecosystems health, safe drinking water and safe sufficient food. Globally, people at greatest risk of adverse health effects associated with climate change include children, the elderly and other vulnerable groups. Temperature-related death and illness, extreme events, polluted or stressed ecosystems represent relevant issues raising concern for both health and economic consequences. Read More

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http://dx.doi.org/10.4415/ANN_19_04_04DOI Listing

Multiple chemical sensitivity: pursuit of a scientific consensus, need for a public health response. Commentary.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):319-322

Dipartimento Ambiente e Salute, Istituto Superiore di Sanità, Rome, Italy.

On the international scene, Multiple Chemical Sensitivity (MCS) is defined, by several experts, as a multisystem syndrome that develops following chronic exposures to low doses of common chemical contaminants. Its general characteristics are, however, the object of conflicting opinions and a source of debate and research aimed at the appropriate nosological and therapeutic frameworks. In the face of a potentially debilitating trend, both in the occupational and in the economical and social sphere, the scientific community has not so far found an agreement. Read More

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http://dx.doi.org/10.4415/ANN_19_04_03DOI Listing

Ethics committees and research in Italy: seeking new regulatory frameworks (with a look at the past). Commentary.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):314-318

President, Istituto Superiore di Sanità, Rome, Italy.

The legislation of Italy and the European Union requires a shift in terms of the organisation and national regulation of ethics committees and clinical trials. More generally, this affects the entire sphere of biomedical research. The first part of this contribution provides a brief review of the history of ethics committees in Italy. Read More

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http://dx.doi.org/10.4415/ANN_19_04_02DOI Listing

Policies and actions to tackle rare diseases at European level.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):296-304

Centro Nazionale Malattie Rare, Istituto Superiore di Sanità, Rome, Italy.

Rare diseases (RDs) are defined by the European Union as life-threatening or chronically debilitating conditions, with a prevalence lower than 5 per 10 000 inhabitants. Around 6000 diseases are described, affecting between 6% and 8% of the European population. Due to their severity, diffusion and multi-faceted aspects, RD are an area where collaboration in public health, health care and research provides a major integrated added value. Read More

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http://dx.doi.org/10.4415/ANN_19_03_17DOI Listing
February 2020
1 Read

Resilience in rare disease networks.

Authors:
Edmund Jessop

Ann Ist Super Sanita 2019 Jul-Sep;55(3):292-295

National Health Service - NHS England, London, United Kingdom.

A resilient system is one which continues to perform its function or goal during a period of change. The original concept was formed around return to the status quo after major external shocks. Recently the concept of "everyday resilience" has been proposed. Read More

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http://dx.doi.org/10.4415/ANN_19_03_16DOI Listing
February 2020

Patient empowerment of people living with rare diseases. Its contribution to sustainable and resilient healthcare systems.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):283-291

EURORDIS - Rare Diseases Europe, Paris, France.

The notion of empowerment is linked to patients' everyday life and is the base allowing for the patient engagement through which individuals and communities are able to express their needs, are involved in decision-making, take action to meet those needs. In the field of rare diseases, empowerment strategies have greater value due to low prevalence, lack of expertise, poor quality of life. Avenues to patient empowerment are: health literacy and capacity-building; shared decision-making; support to self-management. Read More

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http://dx.doi.org/10.4415/ANN_19_03_15DOI Listing
February 2020

Integrated care for healthcare sustainability for patients living with rare diseases.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):276-282

Centro Nazionale Malattie Rare, Istituto Superiore di Sanità, Rome, Italy.

The increasingly complex and multidimensional care request, combined with the presence of increasingly aware and demanding patients, accentuates the need for new strategies to preserve health systems economic sustainability. Therefore, integration mechanisms reveal an essential condition for ensuring continuity of care. The paper reviews the main literature available on the integration of heal services and relates it to rare diseases. Read More

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http://dx.doi.org/10.4415/ANN_19_03_14DOI Listing
February 2020

Health systems for rare diseases: financial sustainability.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):270-275

ServizioFormazione, Istituto Superiore di Sanità, Rome, Italy.

Introduction: Distribution of public spending on health depends on a variety of factors, from disease burden and system priorities to organisational aspects and costs. Nowadays, virtually all health care systems face serious sustainability challenges. This is particularly true for rare diseases, where priority setting involves complex and often controversial value-laden choices. Read More

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http://dx.doi.org/10.4415/ANN_19_03_13DOI Listing
February 2020

Health systems sustainability in the framework of rare diseases actions. Actions on educational programmes and training for professionals and patients.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):265-269

Centro Nazionale Malattie Rare, Istituto Superiore di Sanità, Rome, Italy.

Rare disease community is one of the largest patient populations in the world estimated to be 350 million of people. Collectively common, rare diseases pose a significant medical and economic burden for health systems worldwide. In this respect, rare diseases are considered a priority of public health. Read More

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http://dx.doi.org/10.4415/ANN_19_03_12DOI Listing
February 2020

Primary prevention as an essential factor ensuring sustainability of health systems: the example of congenital anomalies.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):258-264

Dipartimento di Sicurezza Alimentare, Nutrizione e Sanità Pubblica Veterinaria, Istituto Superiore di Sanità, Rome, Italy.

Protection of early development contributes to health of next generations. Congenital anomalies (and other adverse reproductive outcomes) are an important public health issue and early indicator of public health risks, as early development is influenced by many risk factors (e.g. Read More

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http://dx.doi.org/10.4415/ANN_19_03_11DOI Listing
February 2020
1 Read

Value based healthcare for rare diseases: efficiency, efficacy, equity.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):251-257

Fondazione Censis, Area Welfare e Salute, Rome, Italy.

The paper reviews the literature available on value based health care and relates it to rare diseases. Starting from the economic definition of value and healthcare evaluation, efficacy and efficiency, it includes the equity dimension to define value-based healthcare. It embraces also the cultural framework associated to the concepts of health and disease, normal and pathological, right or wrong for the patient. Read More

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http://dx.doi.org/10.4415/ANN_19_03_10DOI Listing
February 2020
4 Reads

Health systems sustainability for rare diseases. Preface.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):249-250

Centro Nazionale Malattie Rare, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.4415/ANN_19_03_09DOI Listing
February 2020

Integrated gastroenterology and rheumatology ambulatory: an innovative approach for enteropathic spondyloarthritis early diagnosis.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):246-248

Medicina Interna, Gastroenterologia e Reumatologia, Ospedale Nuovo Regina Margherita, Rome, Italy.

Patients with inflammatory bowel disease (IBD) may develop rheumatic diseases, particularly enterophatic spondyloarthritis (ESpA). Similarly, an IBD may develop in patients with SpA. Management of these patients in a dedicated ambulatory could be advantageous. Read More

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http://dx.doi.org/10.4415/ANN_19_03_08DOI Listing
February 2020
1 Read

Training in pediatric palliative care in Italy: still much to do.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):240-245

Polistudium SRL, Milan, Italy - Dipartimento di Scienze Chirurgiche e Diagnostica Integrata, Università degli Studi di Genova, Genoa, Italy.

Aim: This survey investigated the availability of training programs in pediatric palliative care (PPC) for Italian postgraduates specializing in pediatric medicine.

Methods: Two questionnaires were developed: (i) a questionnaire addressed to the Directors of Italian postgraduate pediatric medicine programs (n = 37); and (ii) a survey to the postgraduate students in pediatric medicine at the University Hospitals of Padua and Udine (n = 127).

Results: 14 directors participated (response rate: 37. Read More

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http://dx.doi.org/10.4415/ANN_19_03_07DOI Listing
February 2020

Polypharmacy in the general population of a Northern Italian area: analysis of administrative data.

Authors:
Francesca Valent

Ann Ist Super Sanita 2019 Jul-Sep;55(3):233-239

SOC Istituto di Igiene ed Epidemiologia Clinica, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.

Introduction: The aim of this study was to estimate the prevalence and assess patient-related determinants of polypharmacy in the general population of the Italian area around Udine.

Materials And Methods: A retrospective cohort study was conducted using administrative databases: drug prescriptions, hospital discharges, ambulatory care prescriptions, exemptions from medical charges. Various definitions of polypharmacy were adopted (co-prescription of multiple medications, use of multiple medications for overlapping time periods). Read More

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http://dx.doi.org/10.4415/ANN_19_03_06DOI Listing
February 2020

Design and hygiene issues in sports facilities. A pilot study which investigates fitness centres by using a multidisciplinary tool.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):224-232

Dipartimento di Architettura, Ingegneria delle Costruzioni e Ambiente Costruito (ABC), Politecnico di Milano, Milan, Italy.

Introduction: Awareness of the benefits of the physical activity on health by the general public has increased the number of people who is practicing it in the recent years. The gyms are the primary place - as the main indoor environment - for practicing physical activity.

Methods: A multidisciplinary tool was used primarily to investigate and analyse the general aspects of fitness centres then an assessment tool was created to evaluate a specific aspect such as the location, dimension, maintenance, etc. Read More

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http://dx.doi.org/10.4415/ANN_19_03_05DOI Listing
February 2020

Estimated burden of Chlamydia trachomatis female infection and consequent severe pelvic inflammatory disease, Italy, 2005-2016.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):217-223

Dipartimento Malattie Infettive,Istituto Superiore di Sanità, Rome, Italy.

Chlamydia trachomatis (Ct) is the leading sexually transmitted infection (STI) across Europe. In Italy, Ct prevalence is low in general population, but predominance of asymptomatic infections, passive voluntary reporting, variable diagnostic criteria and coding practices can lead to considerable underestimation, preventing assessment of real burden of disease and health intervention. We analysed data on female genital Ct infection registered in STI sentinel surveillance systems in Italy from 2005 through 2016 and found 3305 women. Read More

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http://dx.doi.org/10.4415/ANN_19_03_04DOI Listing
February 2020
2 Reads

Factors predicting health science students' willingness to be vaccinated against seasonal flu during the next campaign.

Ann Ist Super Sanita 2019 Jul-Sep;55(3):209-216

Dipartimento Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza, "G. D'Alessandro", Università degli Studi di Palermo, Palermo, Italy.

Introduction: Influenza is an infectious disease with a high burden, for which a safe and efficacy vaccine is available. However, vaccination coverage is generally low, also among Health Care Workers (HCW). Health Professions students are comparable to HCW in terms of workplace exposure. Read More

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http://dx.doi.org/10.4415/ANN_19_03_03DOI Listing
February 2020