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Ann Zool Fennici 2008 Jan;45(5):369-384

Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA ( ).

This communication provides an illustration for the use of computer simulations in human immunology. When traditional experiments are impossible, unethical, or unfeasible, in silico modeling procedures may help to fill the gaps in our knowledge of an immune system response to a pathogen. In our study, we define terms and properties of modeled entities: "a clonotype", its distribution, and rank-frequency summaries, and describe properties associated with each of these three clonotype-related entities. Read More