4,631 results match your criteria Annales Pharmaceutiques Francaises[Journal]


Physicochemical stability of norepinephrine bitartrate in polypropylene syringes at high concentrations for intensive care units.

Ann Pharm Fr 2019 Feb 22. Epub 2019 Feb 22.

Pharmacy Department, University Hospital of Nancy, Hôpital Brabois Adultes, Centre Hospitalier Régional Universitaire, Allée du Morvan, 54511 Vandoeuvre-lès-Nancy, France; EA 4360 APEMAC, Université de Lorraine, Nancy, France.

Objectives: Norepinephrine is usually used in emergency situations such as in intensive care units (ICUs) for the restoration of blood pressure. The objective was to study the stability of highly-concentrated solutions of norepinephrine at 0.50mg/mL and 1. Read More

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http://dx.doi.org/10.1016/j.pharma.2019.01.002DOI Listing
February 2019

[Pharmaceutical analysis of medication orders in health care facilities: A France-Quebec comparison].

Ann Pharm Fr 2019 Feb 21. Epub 2019 Feb 21.

Unité de recherche en pratique pharmaceutique, département de pharmacie, CHU Sainte-Justine, Montréal (Québec), Canada; Faculté de pharmacie, université de Montréal, Montréal (Québec), Canada. Electronic address:

Objectives: The pharmaceutical analysis of drug prescriptions is one of the key steps in the drug circuit. This mandatory regulatory practice in France and Quebec is based on national standards. The main objective of this work was to compare the practical methods of pharmaceutical analysis performed in French and Quebec university hospitals. Read More

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http://dx.doi.org/10.1016/j.pharma.2019.01.001DOI Listing
February 2019

New insights into the chemical behavior of S-oxide derivatives of thiocarbonyl-containing antitubercular drugs and the influence on their mechanisms of action and toxicity.

Ann Pharm Fr 2019 Mar 29;77(2):126-135. Epub 2019 Jan 29.

CNRS, Laboratoire de Chimie de Coordination, LCC, UPR 8241, 205, route de Narbonne, BP 44099, 31077 Toulouse, cedex 4, France. Electronic address:

Objectives: This work aims at getting more insights into the distinct behavior of S-oxide derivatives of thiocarbonyl-containing antitubercular drugs, in order to better understand their mechanism of action and toxicity.

Methods: Computational calculation of relative free energy (ΔΔG) of S-oxide tautomers (sulfine R-C [SO]NH2), sulfenic acid (R-C [S-OH]NH) and sulfoxide (R-C [SHO]NH) derived from thioamide and thiourea antitubercular drugs and an update of the literature data with a new point of view about how the structural features of oxidized primary metabolites (S-oxide) can influence the outcome of the reactions and be determinant for the mechanisms of action and of toxicity of these drugs.

Results: The calculated free energy of S-oxide tautomers, derived from thioamide and thiourea-type antitubercular drugs, supported by some experimental results, revealed that S-oxide derivatives could be found under sulfine and sulfenic acid forms depending on their chemical structures. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.11.004DOI Listing
March 2019
1 Read

IPADAM "Pharmaceutical interventions on the issue of pharmaceutical records and self-medication" quanti survey in 482 French pharmacies.

Ann Pharm Fr 2019 Jan 23. Epub 2019 Jan 23.

UPU ACCePPT, Pharmacy UFR, the University of Clermont Auvergne, 63000 Clermont-Ferrand, France.

Objectives: This study aims to: (i) quantify the number of pharmaceutical interventions (PIs) linked to spontaneous requests for the two oral target molecules, ibuprofen and pseudoephedrine (ii) analyse the causes and proposed solutions (iii) quantify the number of registrations in the patient's pharmaceutical record and identify the various causes of non-registration.

Methods: The study was conducted over a 2 weeks' period in the months of February and April 2014 in 482 pharmacies affiliated to the training supervisor associations of 8 French Faculties of Pharmacy. Data regarding spontaneous requests for the target molecules was collected, with due respect to a patient care flow chart at the pharmacy, by incorporating the systematic proposal for registration of the medication in the patient's pharmaceutical record. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.12.002DOI Listing
January 2019

Development of a new liquid chromatographic method for the simultaneous separation of ciprofloxacin degradation products with 5-hydroxymethyl-furfural, impurity of D-glucose, in an intravenous solution for perfusion.

Ann Pharm Fr 2019 Jan 22. Epub 2019 Jan 22.

Department of Pharmacy, Analytical Chemistry Laboratory, University of Monastir, Road of Ibn Sina, 5000 Monastir, Tunisia.

The place occupied by fluoroquinolones is very important clinically. Ciprofloxacin has been the most widely prescribed one which exhibits good activity against Pseudomonas aeruginosa and Acinetobacter. D-glucose is frequently used as an excipient in most formulations for perfusion solutions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034509183018
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http://dx.doi.org/10.1016/j.pharma.2018.11.006DOI Listing
January 2019
9 Reads

[Assessment of the use by hospital pharmacists of the opinions issued by the Haute Autorité de santé and the economic analysis tools proposed to them].

Ann Pharm Fr 2019 Mar 23;77(2):159-167. Epub 2019 Jan 23.

Inserm UMR S 1145, faculté de pharmacie de Paris, institut droit et santé, université Paris Descartes, Sorbonne Paris Cité, 75005 Paris, France; Service évaluations pharmaceutiques et bon usage, agence générale des équipements et des produits de santé, Assistance publique-Hôpitaux de Paris, 75005 Paris, France.

Background: In French hospitals, the supply and management of drugs are missions of pharmacists. The aim of this study is to assess the use of efficacy and economics opinions of the Haute Autorite de santé (HAS) in hospital referencing of drugs in France in 2017.

Methods: A questionnaire for hospital pharmacists was developed to establish their knowledge and their uses of Transparency Commission and Economic and Public Health Evaluation Committee opinions. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.10.004DOI Listing
March 2019
1 Read

[Involvement of hospital pharmacy technician for expanding medication reconciliation process in France: Actors' willingness and opinions].

Ann Pharm Fr 2019 Mar 21;77(2):168-177. Epub 2019 Jan 21.

Pharmacie, CHU Grenoble Alpes, 38700 La Tronche, France; Université Grenoble Alpes/CNRS/TIMC - IMAG UMR5525/Themas, 38700 La Tronche, France. Electronic address:

Objectives: Medication reconciliation is widely promoted by international health authorities. Its expansion requires human resources, which are limited and unequally distributed among health care facilities. Recent international studies support the involvement of pharmacy technician in the medication reconciliation process but his role remains unstructured in France. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.11.003DOI Listing

A network of weak hydrogen bonds in the crystal structure of Tetrazepam.

Ann Pharm Fr 2019 Mar 21;77(2):121-125. Epub 2019 Jan 21.

Faculté de pharmacie, université Paris Descartes, USPC, 4, avenue de l'Observatoire, 75006 Paris, France; Laboratoire SMS - EA 3233, Normandie université, université de Rouen, 76821 Mont Saint-Aignan, France. Electronic address:

The crystal structure of tetrazepam, a benzodiazepine derivative formerly used for its muscle relaxant properties, has been solved and found to be monoclinic, space group P2/c, with lattice parameters a=12.7386(7)Å, b=11.3774(7)Å, c=10. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.11.002DOI Listing

Drug shortages in Canada: Data for 2016-2017 and perspectives on the problem.

Ann Pharm Fr 2019 Jan 19. Epub 2019 Jan 19.

Unité de recherche en pratique pharmaceutique, département de pharmacie, CHU Sainte-Justine, 3175, chemin de la Côte-Sainte-Catherine, H3T1C5 Montréal, QC, Canada. Electronic address:

Objectives: Many signs point to the growing importance of drug shortages in Canada and around the world. Although drug shortages affect clinicians and patients every day, there is a paucity of literature describing the specific problems experienced and their clinical consequences. To describe the drug shortage situation in Canada in 2016-2017 and to discuss this issue in the Canadian context. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.11.007DOI Listing
January 2019
1 Read

[Interest of several pharmaceutical activities to secure the care pathway of elderly patients?]

Ann Pharm Fr 2019 Jan 19. Epub 2019 Jan 19.

Pôle pharmaceutique, CHU de Besançon, 3, boulevard Alexandre-Fleming, 25030 Besançon cedex, France; Inserm, EFS BFC, UMR1098, interactions hôte-greffon-tumeur - ingénierie cellulaire et génique, University of Bourgogne Franche-Comté, boulevard Alexandre-Fleming, 25020 Besançon cedex, France.

Objectives: In order to prevent medication errors during patient's care pathway, all transition steps must be secured. The main objective of this study was to assess the interest of medication review at hospital discharge on the sustainability of therapeutic optimizations made during hospitalisation in a geriatric population.

Material And Methods: This was a three months prospective, single-centre study performed in an acute geriatric unit of a university hospital. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.11.001DOI Listing
January 2019
1 Read

[Evaluation of knowledge and perceptions of pharmacists and residents pharmacists about bibliometric indicators applied to the scientific literature in pharmacy].

Ann Pharm Fr 2019 Jan 18. Epub 2019 Jan 18.

Unité de recherche en pratique pharmaceutique, CHU Sainte-Justine, Montréal, Québec, Canada; Faculté de pharmacie, université de Montréal, Montréal, Québec, Canada. Electronic address:

Objectives: Evaluate the level of knowledge and perceptions of French and Quebec hospital's pharmacists/residents about bibliometrics indicators applied in pharmacy. Identify the determinants associated with this knowledge.

Methods: This is a descriptive cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.11.005DOI Listing
January 2019

[Indicators of research impact: Tools for measuring journals, researchers and published articles in health - Pharmaceutical perspective].

Ann Pharm Fr 2019 Jan 26;77(1):1-14. Epub 2018 Oct 26.

Unité de recherche en pratique pharmaceutique et département de pharmacie, centre hospitalier universitaire Sainte-Justine, 3175, chemin de la Côte Sainte-Catherine, H3T 1C5 Montréal, QC, Canada; Faculté de pharmacie, université de Montréal, Montréal, QC, Canada. Electronic address:

There are several indicators to evaluate the impact of the scientific publication in pharmacy. Given their number, complexity, heterogeneity, strengths and weaknesses, we believe that pharmacists are not sufficiently familiar with these indicators. The main objective is to present an inventory of available indicator to measure the research impact. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.09.001DOI Listing
January 2019
1 Read

[Pharmaceutical interviews for rheumatoid arthritis patients: Perceptions and expectations of community pharmacists].

Ann Pharm Fr 2019 Mar 21;77(2):146-158. Epub 2018 Dec 21.

Service pharmaceutique, groupement hospitalier Edouard-Herriot, hospices civils de Lyon, 5, place d'Arsonval, 69003 Lyon, France; Laboratoire parcours santé systémique, EA 4129, faculté de médecine Laennec, université Lyon 1, 7-11, rue Guillaume-Paradin, 69008 Lyon, France; Faculté de pharmacie, université Lyon 1, 8, avenue Rockefeller, 69008 Lyon, France. Electronic address:

Introduction: Rheumatoid arthritis has a low level of medication adherence. Abroad, the community pharmacist has a positive impact on the patients' adherence in several chronic diseases. In France, community pharmacists' missions are developing with the implementation of pharmaceutical interviews. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.10.003DOI Listing
March 2019
1 Read

Development of bioanalytical HPLC method for simultaneous determination of the antialzhiemer, donepezil hydrochloride and the antidepressant, citalopram hydrobromide in raw materials, spiked human plasma and tablets dosage form.

Ann Pharm Fr 2019 Mar 24;77(2):112-120. Epub 2018 Oct 24.

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, 44519, Zagazig, Egypt. Electronic address:

Objectives: A novel, fast and sensitive HPLC method has been developed for the simultaneous bioanalytical determination of Donepezil hydrochloride (DON) and Citalopram hydrobromide (CTP) in raw materials, spiked human plasma and tablets.

Materials And Methods: Elution of both drugs was achieved with very good resolution using a RP-C18 chromatographic column, samples were analyzed using Hypersil Gold (100mm×4.6mm), 5μm particle size column and an isocratic binary mobile phase consists of phosphate buffer (0. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.09.004DOI Listing
March 2019
2 Reads

Selective and validated kinetic spectrophotometric method for the determination of irbesartan in pure and pharmaceutical formulations.

Authors:
S Ashour R Bayram

Ann Pharm Fr 2019 Mar 22;77(2):101-111. Epub 2018 Nov 22.

Departments of Pharmaceutical Chemistry, Pharmacy Program, Batterjee Medical College, Jeddah, Saudi Arabia.

A novel-coupling reagent is used for the simple and sensitive kinetic spectrophotometric determination of irbesartan (IRB) in pure or pharmaceutical formulations. The method utilizes an oxidative coupling reaction based on oxidation of 3-methyl-2-benzothiazolinone hydrazone hydrochloride monohydrate (MBTH) with Ce(IV) in 2% sulfuric acid medium, followed by coupling the produced electrophilic intermediate (diazonium salt of the reagent) with IRB to give greenish-blue colored product (1:1, stoichiometry) having maximum absorption at 629nm and the colored species is stable for more than 1h. The initial rate and fixed time (at 35min) methods are adopted for determination of IRB concentration. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.09.002DOI Listing
March 2019
1 Read

[Benefit of the geriatric mobile unit's intercession on the quality of medical prescriptions for the elderly: Past year assessment].

Ann Pharm Fr 2019 Mar 2;77(2):136-145. Epub 2018 Nov 2.

Médecine gériatrique, pôle de gérontologie clinique, CHU de Bordeaux, avenue du Haut-Lévêque, 33604 Pessac, France.

Our multidisciplinary geriatric mobile unit works in behalf of the frail elderly people, aged at least 75, who are in loss of self-reliance. One of its main aims is so optimize medical prescriptions. The purpose of this study was to show the benefit of geriatrician and pharmacist interventions over the quality of medical prescriptions for the elderly. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.10.002DOI Listing
March 2019
20 Reads

[The impact of POP (Publish Or Perish) culture on pharmaceutical journals].

Authors:
A Guérin A Astier

Ann Pharm Fr 2018 11;76(6):419-420

Service pharmacie, CHU Henri-Mondor, 51, avenue de Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00034509183016
Publisher Site
http://dx.doi.org/10.1016/j.pharma.2018.10.001DOI Listing
November 2018
9 Reads

Promoting oral potassium administration in a tertiary care hospital: An eleven-year study.

Ann Pharm Fr 2019 Jan 6;77(1):38-45. Epub 2018 Oct 6.

Service pharmaceutique, hospices Civils de Lyon, hôpital de la Croix-Rousse, groupement hospitalier Nord, 103, grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France. Electronic address:

Introduction: Potassium is used to treat or prevent hypokalemia and exhibits all the characteristics of an intravenous to oral therapy conversion program. Despite this, the intravenous route for potassium replacement seems frequently unjustified.

Objectives: To determine the impact of a conversion program on the use of intravenous and oral galenic forms in a university tertiary care hospital. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.09.003DOI Listing
January 2019
3 Reads

[Quality control of mixtures for pediatric parenteral nutrition: Validation of sodium and potassium assay method].

Ann Pharm Fr 2019 Jan 21;77(1):85-91. Epub 2018 Sep 21.

Laboratoire national de contrôle des médicaments, 13, rue Jbel Lakhdhar 1006 Bab Saadoun, Tunis, Tunisie.

Objectives: Control of electrolyte concentration in mixtures for parenteral nutrition (MPN) for newborns is crucial before the release of the final product. We aimed to assess the validation of the electrolytes assay in MPN.

Methods: Electrolytes assay was performed with Ilyte Analyzer. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.08.004DOI Listing
January 2019
4 Reads

[Securing the distribution of patient-specific unit dose medication following the installation of a unit dose dispensing system: Cartography of risks a priori within a hospital pharmacy].

Ann Pharm Fr 2018 Nov 19;76(6):473-488. Epub 2018 Sep 19.

Service pharmacie, PUI Fernand Widal, groupe hospitalier Saint Louis, Lariboisière, Fernand Widal, 200, rue du Faubourg-Saint-Denis, 75010 Paris, France.

Introduction: With a view to reinforcing the security of the drug distribution process, the hospital pharmacy has decided to automate the patient-specific unit dose distribution system which, up to now was performed manually, through the acquisition of a unit dose dispensing system: the ACCED S 300 (ECODEX). The aim of this work is to realize a cartography of risks, focused on the dispensing stage, prior to the implementation of the automated system.

Materials And Method: A multidisciplinary group applied the preliminary risk analysis (PRA) technique. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.05.004DOI Listing
November 2018
13 Reads

Validated RP-HPLC method for quantification of felodipine in rabbit plasma: Application in a bioequivalence study.

Ann Pharm Fr 2019 Jan 19;77(1):15-27. Epub 2018 Sep 19.

Rajarambapu College of Pharmacy, Kasegaon, Dist-Sangli, Maharashtra 415404, India.

Objective: The aim of present study was to develop a simple, rapid, selective, sensitive and robust reverse phase high performance liquid chromatographic method for quantification of felodipine in rabbit plasma at the wavelength of 360nm.

Method: Protein was precipitated from rabbit plasma sample by addition of acetonitrile as a vehicle. An isocratic elution of samples was performed on capcell pak C DD S5 column (4. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.08.002DOI Listing
January 2019
2 Reads

[Design and assessment of a outpatient living with PICC-line support program: A pilot study].

Ann Pharm Fr 2019 Jan 20;77(1):62-73. Epub 2018 Sep 20.

GH HUPS, service pharmacie, hôpital Antoine-Béclère, 157, rue de la Porte-de-Trivaux, AP-HP, 92140 Clamart, France.

The peripheral insertion central catheter (PICC-Line) is indicated for long term intravenous medication administration. Some adverse events (AE) might occur, especially for patients after hospital discharge. Therefore, patient empowerment about the side effects and precaution for use is essential to prevent potential patient harm. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.07.001DOI Listing
January 2019
10 Reads

First international database of research teams in stability and compatibility of medications: An additional function in the Stabilis database.

Ann Pharm Fr 2018 Nov 19;76(6):436-443. Epub 2018 Sep 19.

Pharmacie à usage intérieur, centre hospitalier régionale universitaire de Nancy, allée du Morvan, 54511 Vandoeuvre-lès-Nancy, France; Université de Lorraine, EA 4360 APEMAC, 54000 Nancy, France.

A new function on the international database Stabilis has been created: a database of research teams involved in stability and compatibility studies of drugs. The first part is descriptive. For each team, the list of publications and of molecules studied can be edited. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.08.001DOI Listing
November 2018
1 Read

[We have to stop talking about "non compliant" patients but rather about patients with difficulties of medication adherence].

Ann Pharm Fr 2018 Nov 7;76(6):489-498. Epub 2018 Sep 7.

Laboratoire inter universitaire de psychologie, PC2S, EA 4145, université Grenoble-Alpes, 38400 Saint Martin d'Hères, France.

Medication adherence can be defined as the link between "what the patient implements" and "what the patient and his doctor have decided together after negotiating without constrains". This definition should be put into perspective with the chronology of the disease and the way the patient experiences it. Counselling actions should always be adapted to the situation and negotiated with the patient, all along the process of care. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.07.006DOI Listing
November 2018
2 Reads

Development and application of degradation kinetics of thin layer chromatographic densitometry and conductometric methods for butoconazole nitrate determination.

Ann Pharm Fr 2018 Nov 29;76(6):453-463. Epub 2018 Aug 29.

Department of Analytical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig El Gamaa Street, 44519 Sharkia, Egypt.

Two simple methods were developed for determination of butoconazole nitrate (BN). The first developed method was stability-indicating HPTLC-densitometric method (method A) which is based on the quantitative densitometric separation of butoconazole nitrate (BN) from its degradation products on silica gel 60 F and measurement of the bands at 290nm. The developed stability study of BN was performed under different stress conditions including oxidative, hydrolytic, thermal and photolytic. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.07.007DOI Listing
November 2018
1 Read

Simultaneous HPLC determination of alfuzosin, tamsulosin and vardenafil in human plasma and pharmaceutical formulations using time programmed fluorescence detection.

Ann Pharm Fr 2019 Jan 29;77(1):28-37. Epub 2018 Aug 29.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, International Coastal Road, Gamasa City, Dakahliya, Egypt. Electronic address:

Alfuzosin and tamsulosin are recently co-administrated with vardenafil to treat symptoms of benign prostatic hyperplasia and erectile dysfunction. A highly sensitive and simple liquid chromatographic method was developed and validated for the simultaneous determination of the three drugs using moxifloxacin as an internal standard. Isocratic separation was achieved within 7. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.08.003DOI Listing
January 2019
3 Reads

[Berger's disease associated to an adalimumab-treated rheumatoid arthritis].

Ann Pharm Fr 2018 Nov 23;76(6):499-503. Epub 2018 Aug 23.

Service de rhumatologie, centre hospitalier de Valence, 179, boulevard Marechal-Juin, 26000 Valence, France.

Berger's disease is characterized by deposits of immunoglobulin A in the glomerular mesangium. We report a case of a patient who was treated by adalimumab for a rheumatoid arthritis (RA). The patient is 45 years old and is treated for RA since 1996. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.07.005DOI Listing
November 2018
8 Reads

RETRACTED: Impact économique de la centralisation de la préparation de la chimiothérapie : expérience de l’Institut national d’oncologie de Rabat.

Ann Pharm Fr 2018 09;76(5):418

Service de pharmacie, Institut national d'oncologie, centre hospitalier Ibn-Sina de Rabat, 1000 Rabat, Maroc; Laboratoire de pharmacologie et de toxicologie, faculté de médecine et de pharmacie de Rabat, université Mohamed V, Rabat, Maroc.

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http://dx.doi.org/10.1016/j.pharma.2018.07.004DOI Listing
September 2018
2 Reads

[How to measure real-world effectiveness?]

Ann Pharm Fr 2018 Nov 10;76(6):421-435. Epub 2018 Aug 10.

Réseau d'évaluation en économie de la santé (REES), 28, rue d'Assas, 75006 Paris, France. Electronic address:

The new use of medico-administrative databases is a major change in the medical assessment field. Given the limits of the randomized clinical trials when it comes to accurately represent the heterogeneity and complexity of medical care in a real-world context, an increasing demand of observational studies comes from healthcare systems as decision tools. The lack of intervention generates real-world data and assesses both the care and the outcomes of patients in routine practice. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.07.003DOI Listing
November 2018
11 Reads

[Subcontracting a steam sterilization activity: Impact on surgical instruments].

Ann Pharm Fr 2019 Jan 10;77(1):74-84. Epub 2018 Aug 10.

PUI-secteur prédésinfection mécanisée, centre hospitalier Victor-Dupouy, 69, rue du Lieutenant-colonel-Prudhon, 95100 Argenteuil, France.

Subcontracting our institution's sterilization activity induced the implementation of an automated cleaning facility. Following this development, some of the resterilizable stainless steel needle holders started to show abnormal corrosion. Our study goal was to investigate the causes of this corrosion in order to optimize the sterilization circuit. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.07.002DOI Listing
January 2019
2 Reads

Emergence of cardio-oncology.

Ann Pharm Fr 2018 Nov 31;76(6):504-506. Epub 2018 Jul 31.

CNRS/Université de Strasbourg, Laboratory of Biomolecules (UMR7203), Sorbonne University-CNRS, Paris, France.

Cardio-oncology is a new discipline that focuses on understanding, detection, monitoring and treating cardiovascular disease during and after cancer treatment. The development of this emerging field is based on an interdisciplinary collaboration between cardiology and oncology researchers and clinicians. Cardio-oncology aims at identifying how cancer therapies impact cardiovascular homeostasis, particular risk factors, diagnostic biomarkers and novel therapeutic approaches to help to effectively detect, prevent and cure the cardiotoxicity. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.06.003DOI Listing
November 2018
3 Reads

[Medical devices used in digestive system surgical procedures: What's the cost?]

Ann Pharm Fr 2019 Jan 31;77(1):46-61. Epub 2018 Jul 31.

Service pharmacie-stérilisation, hôpital de Hautepierre, hôpitaux universitaires de Strasbourg, 1, avenue Molière, 67098 Strasbourg, France.

Objective: Medical devices innovations and associated procedures represent a large part of health facilities budget. The aim of this work was to evaluate the cost of medical devices used during different surgical procedures. This cost was compare with the revenue collected from hospital stay pricing. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.06.002DOI Listing
January 2019
3 Reads

[Evaluation of the relevance of the leak water test for the control of sterilization containers].

Ann Pharm Fr 2018 Nov 31;76(6):464-472. Epub 2018 Jul 31.

Pharmacie à usage intérieur, centre hospitalier Métropole Savoie, 73100 Aix-Les-Bains, France.

Objectives: The objective is to check the maintaining performance of filter barrier in sterilizations containers with the leakage rupture the junction tank/lid of the container. In order to control the good sealing performance, we use the water leak test as described in the normative document AFNOR FD S98-053. Does the leakage rupture cause the contamination of containers during the storage or transport between two sterilization units?

Method: We use 5 sets of 3 different containers (the first without barrier system (positive control), the others with barrier system (the second with positive water test and the third with negative water test)). Read More

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http://dx.doi.org/10.1016/j.pharma.2018.05.003DOI Listing
November 2018
2 Reads

[Retrocession, a profitable but risky activity].

Ann Pharm Fr 2018 Sep 23;76(5):391-398. Epub 2018 Jun 23.

Service de pharmacie, centre hospitalier Asselin Hedelin, 14, avenue FOCH, 76190 Yvetot, France. Electronic address:

The retrocession (out-patient dispensing of hospital-reserved drugs)is a pharmaceutical critical activity requiring a care security with a territorial approach. In this drug supply chain, the pharmacist is the last step before the drug administration and the economic profitability is questionable. In this context, a risk mapping and an economic evaluation seem necessary. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.05.001DOI Listing
September 2018
4 Reads

Stability of sufentanil and baclofen mixtures for intrathecal analgesia at different concentrations in polypropylene syringes.

Ann Pharm Fr 2018 Nov 23;76(6):444-452. Epub 2018 Jun 23.

Institut de cancérologie de l'Ouest Paul-Papin, pharmacy, 15, rue Bocquel, 49055 Angers, France.

Background: Intrathecal analgesia is a method using various molecules alone or in combination. Among these, the association sufentanil/ baclofen is widely used. Instead of moving patients to the few expert centers taking charge of these specific preparations, it could be better to transport syringes to peripheral centers managing pump refilling. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.05.002DOI Listing
November 2018
4 Reads

[Indirect and mixed mechanisms of action in toxic myopathies].

Ann Pharm Fr 2018 Jul 24;76(4):273-285. Epub 2018 May 24.

Service de toxicologie, CHU Bab-El-Oued, rue Mohamed Lamine Debaghine, 16009 Alger, Algérie; Centre national de toxicologie, route du petit Staouali Delly Brahim, 16062 Alger, Algérie.

Toxic myopathies are a group of pathologies characterized by a structural and/or functional disturbance of muscles induced by an exogenous agent. The most frequent are those induced by drugs used in clinical practice. Illegal drugs, pesticides, solvents, metals and even physical and gaseous agents can cause this kind of disease and exert toxicity on muscle tissues. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.004DOI Listing
July 2018
6 Reads

[IPADAM quali study. Intervention of the Pharmacist in the Issue of Self-medication: Experience of pharmacy team focus groups and patients' perceptions].

Ann Pharm Fr 2018 Sep 22;76(5):399-407. Epub 2018 May 22.

UPU ACCePPT, université Clermont-Auvergne, 63000 Clermont-Ferrand, France.

Objectives: This study had two main aims: (i) document the experience of community pharmacists receiving a spontaneous request for ibuprofen and oral pseudoephedrine, and their use of pharmaceutical records, and (ii) explore patients' perceptions of pharmaceutical records and pharmaceutical interventions.

Methods: The study was conducted over two weeks between February and April 2014 in 482 community pharmacies and 8 French faculties of pharmacy. It was based on data collected by pharmacy team focus groups during patient telephone interviews using standardized question grids. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.04.001DOI Listing
September 2018
5 Reads

A cross-sectional comparison between the perception of physicians and pharmacists concerning the role of the pharmacist in physician training.

Ann Pharm Fr 2018 Sep 23;76(5):408-417. Epub 2018 May 23.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland; Service de Pharmacie, Geneva University Hospitals (HUG), Rue Gabrielle Perret-Gentil, 41205 Geneva, Switzerland. Electronic address:

Objectives: This study aimed to identify and compare physician-pharmacist perceptions concerning drug teaching to physicians by pharmacists in Swiss hospital settings.

Material And Methods: Questionnaires were emailed to all French-speaking physicians (survey A) and pharmacists (survey B) working in Swiss hospitals where medical directors/chief-pharmacists had approved the study. Questions were developed based on previous physician interviews. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.04.002DOI Listing
September 2018
3 Reads

On the dimorphism and the pressure-temperature state diagram of racemic m-nisoldipine, a dihydropyridine calcium ion antagonist.

Ann Pharm Fr 2018 Sep 21;76(5):341-347. Epub 2018 May 21.

Laboratoire SMS, EA 3233, Normandie université, université de Rouen, 76821 Mont-Saint-Aignan, France; Faculté de pharmacie, université Paris-Descartes, USPC, 4, avenue de l'observatoire, 75006 Paris, France. Electronic address:

The pressure-temperature phase diagram of the dimorphism of racemic m-nisoldipine is constructed using temperatures and enthalpies of fusion of forms A and B. At ordinary pressure, the transition from form B to form A is found to occur around 192K, which indicates that these polymorphs are enantiotropically related and that form A is stable at room temperature. Nevertheless, the phase relationship turns to be monotropic when pressures become greater than about 100MPa, which indicates that form B becomes the sole stable phase. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.010DOI Listing
September 2018
3 Reads

[Problems encountered by hospital pharmacists with information systems: Analysis of exchanges within social networks].

Ann Pharm Fr 2018 Sep 21;76(5):368-381. Epub 2018 May 21.

Service pharmacie, centre hospitalier Robert Bisson, 4, rue Roger Aini, 14100 Lisieux, France; Association pour le digital et l'information en pharmacie (ADIPh), 56000 Lorient, France.

Objective: The development of information systems in French hospitals is mandatory. The aim of this work was to analyze the content of exchanges carried out within social networks, dealing with problems encountered with hospital pharmacies information systems.

Methods: Messages exchanged via the mailing list of the Association pour le Digital et l'Information en Pharmacie and abstracts of communications presented at hospital pharmacists trade union congresses were analyzed. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.007DOI Listing
September 2018
12 Reads

What drives intentional overdose with non-prescription drugs? A cross-sectional study.

Ann Pharm Fr 2018 Sep 26;76(5):348-354. Epub 2018 Apr 26.

Pharmacy Practice and Pharmacotherapeutics Department, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates; Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, 27272 Sharjah, United Arab Emirates. Electronic address:

Background: Use of overdosage of Non-Prescription Drugs (NPD) among university students is a serious public health issue. However, there are no extensive studies that measured the prevalence of taking more than the recommended dose of NPD and/or identified the risk associated with this behavior among university students.

Objectives: This study was undertaken to assess the prevalence and associated risks of self-overdosage with NPDs in university students in United Arab Emirates (UAE). Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.008DOI Listing
September 2018
3 Reads

[Assessing post-hospitalization therapeutic ranges in elderly patients treated for atrial fibrillation with vitamin k antagonists].

Ann Pharm Fr 2018 Sep 26;76(5):382-390. Epub 2018 Apr 26.

Service d'accueil des urgences, centre hospitalier Saint-Esprit, route de la Villeneuve-sur-Lot, 47923 Agen cedex 9, France. Electronic address:

Background: In France, anticoagulants are among the most recommended treatments for serious accidents, particularly among the elderly.

Objectives: The purpose of this study was to evaluate the impact of practical and validated tools designed to reduce the negative effects of vitamin K antagonist (VKA) treatments by assessing patients before and after the tools were implemented.

Methods: An exhaustive before and after multi-centric cohort study was performed in the Agen territory. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.009DOI Listing
September 2018
6 Reads

[Which information is given during the purchase of an HIV self-test in a Caen pharmacy? A Comprehensive transversal and observational study using surveys, without modification of practice].

Authors:
S Guitton A Rabiaza

Ann Pharm Fr 2018 Sep 16;76(5):355-360. Epub 2018 Apr 16.

Département de médecine générale, Normandie université, 2, rue des Rochambelles, 14032 Caen cedex 5, France.

Introduction: HIV infection affects about 150,000 people in France. In total, 30,000 of them are unaware of their serostatus. In this context, HIV self-testing has arrived in France in September 2015. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.005DOI Listing
September 2018
4 Reads

[Cost of clotting factors in hospitalization].

Ann Pharm Fr 2018 Sep 11;76(5):361-367. Epub 2018 Apr 11.

Service de pharmacie clinique, hôpitaux universitaires Paris centre, AP-HP, site Cochin, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.

Objectives: Hemophilia is a rare genetic disease, characterized by uncontrolled bleeding. Injections of clotting factor are the principal are the principal treatment. This drug is very expensive. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.006DOI Listing
September 2018
5 Reads

Oral pentobarbital suspension for children sedation during MR imaging.

Ann Pharm Fr 2018 Jul 11;76(4):286-290. Epub 2018 Apr 11.

Service pharmacie clinique, hôpital Jean-Verdier, hôpitaux universitaires de Paris-Seine-Saint-Denis, Bondy, France.

Objectives: The efficacy and safety of an oral pentobarbital suspension for sedation during pediatric MR imaging were assessed.

Methods: Data were recorded from October 2016 to January 2017. The exact dose of oral pentobarbital suspension was given for each child with an oral syringe. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.002DOI Listing
July 2018
6 Reads

Immunoglobulin G particles manufacturing by spray drying process for pressurised metered dose inhaler formulations.

Ann Pharm Fr 2018 Jul 5;76(4):291-298. Epub 2018 Apr 5.

UNIROUEN, SMS EA 3233, Normandie université, 76821 Mont-Saint-Aignan cedex, France.

Objective: The objective of this work is to show the feasibility of manufacturing from a spray drying process particles containing immunoglobulin G capable of being administered by inhalation via a pressurized metered dose inhaler.

Methods: Spray drying were made from aqueous solutions containing IgG and two types of excipients, mannitol and trehalose, with two ratios: 25% w/w and 75%w/w. The physicochemical and aerodynamic properties of the powders obtained were characterized just after manufacturing and after 1 month of storage at 40°C/75% RH according to criteria defined as needed to satisfy an inhaled formulation with a pressurized metered dose inhaler. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.003DOI Listing
July 2018
7 Reads

[Implementation and assessment of anticancer drugs batch preparation circuit in a teaching hospital].

Ann Pharm Fr 2018 Jul 4;76(4):306-320. Epub 2018 Apr 4.

Hôpital Saint-Louis, AP-HP, 75010 Paris, France.

Introduction: In 2011, the anticancer preparation unit in a teaching hospital implemented a circuit for batch preparation of anticancer drugs. In this circuit, a manual and a semi-automatic production process coexist. The aim of the study is to describe the circuit in 2016 and to assess the impact of batch preparation in a anticancer preparation unit. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.001DOI Listing
July 2018
5 Reads

[Prevent bacteria from communicating: Divide to cure].

Ann Pharm Fr 2018 Jul 26;76(4):249-264. Epub 2018 Mar 26.

Gene&GreenTK, 19-21, boulevard Jean-Moulin, 13005 Marseille, France. Electronic address:

Quorum Sensing (QS) is a communication system used by numerous bacteria to synchronize their behavior according to the cell density. In this way, bacteria secrete and sense small mediating molecules, called autoinducers (AI), which concentration increases in the environment proportionally to bacterial cell number. QS induces major physiological and phenotypic changes such as virulence induction and biofilm formation. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.02.004DOI Listing
July 2018
5 Reads

Micellar HPLC method for the simultaneous determination of three anticonvulsant drugs in dosage forms and biological fluids. Application to dissolution-rate testing.

Ann Pharm Fr 2018 May 22;76(3):172-186. Epub 2018 Mar 22.

Department of pharmaceutical analytical chemistry, faculty of pharmacy, Mansoura university, 35516 Mansoura, Egypt. Electronic address:

This work describes a micellar liquid chromatographic method which was developed and validated to determine simultaneously three structurally-related antiepileptic drugs; namely carbamazepine (CMZ), oxcarbazepine (OCZ) and eslicarbazepine acetate (ECZ). The analysis was achieved using a phenyl column (250mm×4.6mm i. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.02.003DOI Listing
May 2018
14 Reads

[Market access agreements: Definition and features. Could MAA be defined as a solution for immunotherapy funding by French health system?]

Ann Pharm Fr 2018 Jul 21;76(4):265-272. Epub 2018 Mar 21.

Faculté de pharmacie de Paris, université Paris-Descartes, 4, avenue de l'Observatoire, 75006 Paris, France; Institut droit et santé, Inserm UMR S 1145, université Paris-Descartes, Sorbonne Paris Cité, 45, rue des Saints-Pères, 75270 Paris cedex 6, France.

Over the last few years, many therapeutic innovations have been approved and marketed in France, within a strained financial setting. Legal dispositions allowed manufacturers (LEEM - les enterprises du medicament) and the economic committee for health products (CEPS) to contract various confidential market access agreements to contain health product expenses. The purposes of this article are to define and describe these different existing market access agreements and to open discussion on their applicability to the problematic of immune-oncology drugs financing. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.01.005DOI Listing
July 2018
5 Reads