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    4554 results match your criteria Annales Pharmaceutiques Francaises[Journal]

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    Validated spectrophotometric and chromatographic methods for analysis of the recently approved hepatitis C antiviral combination ledipasvir and sofosbuvir.
    Ann Pharm Fr 2017 Aug 22. Epub 2017 Aug 22.
    Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah 21521, Alexandria, Egypt. Electronic address:
    This work describes five simple and reliable spectrophotometric and chromatographic methods for analysis of hepatitis C antiviral binary mixture of ledipasvir (LPV) and sofosbuvir (SBV). Method I is based on the use of Amax and derivative spectrophotometry with the zero-crossing technique where LPV was determined using its Amax and (1)D amplitudes at 324 and 338nm respectively, while SBV was determined by measuring the (1)D amplitudes at 276nm. Method II involves the application of the ratio spectra derivative spectrophotometry. Read More

    [Use of a Delphi survey to assess the hospital economic impact of innovative products: The example of idarucizumab a dabigatran-specific reversal agent].
    Ann Pharm Fr 2017 Aug 14. Epub 2017 Aug 14.
    Service pharmacie, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France. Electronic address:
    Objectives: The economic impact of therapeutic innovations on the hospital patient management cannot be easily estimated. The objective of this study is to illustrate the use of a Delphi survey as a support tool to identify the changes following the use of idarucizumab in dabigatran-treated patients with uncontrolled/life-threatening bleeding or who required emergency surgery/urgent procedures.

    Methods: The Delphi questionnaires have been administrated to 8 emergency physicians or anesthetists from 6 different hospital centers. Read More

    [A comparative cost analysis of single-use versus reusable fiberoptic bronchoscopes: Is single-use fiberscope worth it?]
    Ann Pharm Fr 2017 Aug 14. Epub 2017 Aug 14.
    Service de pharmacie, centre hospitalier d'Ardèche-Nord, BP 119, rue du Bon-Pasteur, 07103 Annonay cedex, France.
    Objective: To present a minimization-cost analysis to compare reusable and single-use fiberscopes in a French health institution.

    Materials And Methods: The amortization cost assessment has been achieved over a period of five years, and took into account the acquisition and maintenance costs, as well as the costs related to disinfection of reusable fiberscopes. The cost of single-use fiberscopes was calculated according to its acquisition and elimination costs. Read More

    [Particulate contamination associated with the manipulation of drugs in glass ampules: A literature review].
    Ann Pharm Fr 2017 Aug 8. Epub 2017 Aug 8.
    Unité de recherche en pratique pharmaceutique, département de pharmacie, CHU Sainte-Justine, 3175, chemin de la Côte-Sainte-Catherine, H3T1C5 Montréal, Québec, Canada; Faculté de pharmacie, université de Montréal, Montréal, QC, Canada. Electronic address:
    Objectives: The manipulation of drugs from glass ampules can generate particles when the ampule is broken. Several authors recommend the use of filter needle to withdraw the drug content. The aim of this study is to make an assessment of the presence of particles during the manipulation of glass ampules and to discuss the current practices. Read More

    Multivariate statistical process control in product quality review assessment - A case study.
    Ann Pharm Fr 2017 Aug 7. Epub 2017 Aug 7.
    Pharmaceutical and toxicological analysis research team, laboratory of pharmacology and toxicology, faculty of medicine and pharmacy, university Mohammed V. Souissi, avenue Med Belarbi El Alaoui, BP 6203, 10000 Rabat, Morocco. Electronic address:
    According to the Food and Drug Administration and the European Good Manufacturing Practices (GMP) guidelines, Annual Product Review (APR) is a mandatory requirement in GMP. It consists of evaluating a large collection of qualitative or quantitative data in order to verify the consistency of an existing process. According to the Code of Federal Regulation Part 11 (21 CFR 211. Read More

    Extended stability of the rituximab biosimilar CT-P10 in its opened vials and after dilution and storage in polyolefin bags.
    Ann Pharm Fr 2017 Aug 4. Epub 2017 Aug 4.
    UPREC, service de pharmacie, groupe hospitalo-universitaire Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
    The stability of the rituximab biosimilar CT-P10, in 50mL vials at a concentration of 10mg/mL, and after dilution to final concentrations of 1 and 4mg/mL and storage in polyolefin bags at 4°C and 25°C was studied by several orthogonal and complementary methods. No significant change (as defined by a magnitude greater than the inter-batch variability) was observed, for each of the parameters characterizing physical and chemical stability studied, for the two concentrations and temperatures tested, or for any of the three batches tested. This implies that cold-chain rupture and exposure to room temperature up to 15 days both for vials and diluted bags have no deleterious consequence on the quality of the product. Read More

    [Targeted pharmacist-led medication order review in hospital: Assessment of a selection method for drug prescriptions].
    Ann Pharm Fr 2017 Jul 28. Epub 2017 Jul 28.
    Service pharmacie, centre hospitalier Lucien-Hussel, montée du Docteur-Chapuis, 38200 Vienne, France.
    Objectives: The aim of this study was to assess a selection method for drug prescriptions developed at the hospital level that allows to target pharmacist-led medication order review for at-risk patients and drugs.

    Methods: A one-month study has been conducted on all targeted medication orders in 19 care units. Selection criteria have been identified: biological criteria, alert medications and drug interactions. Read More

    A non-interventional retrospective cohort study of the interaction between methotrexate and proton pump inhibitors or aspirin.
    Ann Pharm Fr 2017 Sep 10;75(5):344-348. Epub 2017 Jul 10.
    Division of Clinical Pharmacy, OLVG, Oosterpark 9, 1090HM Amsterdam, Netherlands. Electronic address:
    Introduction: Methotrexate (MTX) is an antifolate drug, which is frequently used in the treatment of cancer. Proton pump inhibitors (PPIs) could delay the elimination of plasma MTX in high-dose MTX therapy by inhibition of tubular secretion, which could lead to MTX toxicity. However, the evidence of the clinical relevance of this drug-drug interaction is inconsistent. Read More

    Preparation and efficacy assessment of malva nut polysaccharide for skin hydrating products.
    Ann Pharm Fr 2017 Jul 6. Epub 2017 Jul 6.
    School of Cosmetic Science, Mae Fah Luang University, 57100 Chiang Rai, Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, 57100 Chiang Rai, Thailand.
    Introduction: Scaphium scaphigerum or malva nut has long been served in Chinese medicine. However, the use of this herb in modern health care applications has, to date, been rarely reported.

    Materials And Methods: Maceration of the herb in water afforded malva nut polysaccharide which was standardized. Read More

    [The roles and the impacts of pharmacists in the management of medical devices at the hospital: A literature review].
    Ann Pharm Fr 2017 Jun 27. Epub 2017 Jun 27.
    Unité de recherche en pratique pharmaceutique, département de pharmacie, CHU Sainte-Justine, 3175, chemin de la Côte-Sainte-Catherine, Montréal, QC, Canada, H3T 1C5; Faculté de pharmacie, université de Montréal, Montréal, QC, Canada. Electronic address:
    Objectives: Identify the training profile and the published evidences about the roles and the impacts of hospital pharmacists in medical devices.

    Methods: A literature review was conducted using Google, Google Scholar and Pubmed for 1990-2016 associated with a manual search conducted in three non-indexed pharmaceutical journals for 2000-2016.

    Results: The analysis of training programs available did not allow us to identify a specific training profile. Read More

    [Synthesis and binding affinity to human steroid hormone receptors of 3-phenoxy-4-hydroxycoumarins and 3-phenoxy-4-phenylcoumarins].
    Ann Pharm Fr 2017 Jun 12. Epub 2017 Jun 12.
    Laboratoire de chimie thérapeutique, faculté de pharmacie de Paris Sud, 5, rue Jean-Baptiste-Clément, 92296 Chatenay-Malabry cedex, France. Electronic address:
    The synthesis and the study of the binding affinity to human receptors of glucocorticoids, mineralcorticoids, androgens, estrogens and progesterone of 3-phenoxy-4-hydroxycoumarins and 3-phenoxy-4-phenylcoumarins were performed. It shows the absence of any binding affinity of all these derivatives to glucocorticoid and mineralcorticoid receptors and a non-selective binding affinity to androgen, oestrogen and progesterone receptors with 3-phenoxy-4-phényl-coumarins. Read More

    [Pharmacist's interview with type 2 diabetes: Development of a follow-up form].
    Ann Pharm Fr 2017 Sep 2;75(5):385-397. Epub 2017 Jun 2.
    Clermont université, université d'Auvergne, EA ACCEPPT, BP 10448, 63000 Clermont-Ferrand, France; Laboratoire de pharmacie galénique, Clermont université, université d'Auvergne, BP 10448, 63000 Clermont-Ferrand, France.
    Objectives: Type 2 diabetes is a major public health concern because of its prevalence, the severity of complications and the financial implications. Compliance and patient's autonomy in medications intake play key roles in the success of treatment. Pharmacists' interviews ensure an optimized and individual follow-up. Read More

    [The French medecine pricing committee].
    Ann Pharm Fr 2017 Sep 2;75(5):373-384. Epub 2017 Jun 2.
    Université Paris Dauphine, 75000 Paris, France. Electronic address:
    The French medicine pricing committee (CEPS) has to reconcile several major constraints, including optimal patient access to medicines and a good control of expenditures on reimbursable medicines. From 2013 to 2015, drug price decreases and discounts obtained by CEPS contributed more than € 5 billion to the balance of the health insurance accounts. As for price setting, there is a significant drop in the prices of medicines in France once they are registered for reimbursement. Read More

    Formulation development and evaluation of antimicrobial polyherbal gel.
    Ann Pharm Fr 2017 Sep 2;75(5):349-358. Epub 2017 Jun 2.
    Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, 415404 Kasegaon, Maharashtra, India.
    Objective: In the recent years, there has been a gradual revival of interest in the use of medicinal plants in developing countries because herbal medicines have been reported safe with minimal adverse side effect especially when compared with synthetic drugs.

    Method: In the present study we prepared gel formulations (formulations A and B) which comprised of ethanolic extract of Azadirachta indica, Curcuma longa, Allium sativum, Ocimum sactum, Cinnamomum zeylanicum nees and Tamarindus indica in a concentration of 0.1 and 0. Read More

    [Critical analysis of reference studies on aluminium-based adjuvants toxicokinetics].
    Ann Pharm Fr 2017 Jul 31;75(4):245-256. Epub 2017 May 31.
    Inserm U955 E10, centre expert de pathologie neuromusculaire, « Biologie du système neuromusculaire », hôpital Henri-Mondor, faculté de médecine, université Paris-Est-Créteil, 94010 Créteil, France. Electronic address:
    We reviewed the three reference toxicokinetic studies commonly used to suggest innocuity of aluminum (Al)-based adjuvants. A single experimental study was carried out using isotopic (26)Al (Flarend et al., 1997). Read More

    [Direct mechanism of action in toxic myopathies].
    Ann Pharm Fr 2017 Sep 17;75(5):323-343. Epub 2017 May 17.
    Service de toxicologie, CHU Bab-El-Oued, rue Mohamed-Lamine-Debaghine, 16009 Alger, Algérie; Centre national de toxicologie, route du Petit-Staouali-Delly-Brahim, 16062 Alger, Algérie.
    Toxic myopathies are a large group of disorders generated by surrounding agents and characterized by structural and/or functional disturbances of muscles. The most recurrent are those induced by commonly used medications. Illicit drugs, environmental toxins from animals, vegetables, or produced by micro-organisms as well as chemical products commonly used are significant causes of such disorders. Read More

    [The French medecine pricing committee and the medicine economic policy: Rules and competences].
    Ann Pharm Fr 2017 Sep 15;75(5):359-372. Epub 2017 May 15.
    Paris sciences et lettres, université Paris Dauphine, 75000 Paris, France. Electronic address:
    The French medicine pricing committee (CEPS), a governmental and inter-institutional body exercises essential competences for the regulation of the economy of the reimbursable drugs in France. It provides a good example of administered price regulation. It also supervises the proper use of products (control of promotion, conventional control of sales volumes). Read More

    UPLC-MS/MS method for determination of sofosbuvir in human plasma.
    Ann Pharm Fr 2017 Jul 8;75(4):257-266. Epub 2017 May 8.
    Department of Pharmaceutical Analysis, St. Paul's College of Pharmacy, Turkayamjal, Hyderabad, TS, India.
    Introduction: A sensitive and rapid method for quantitation of Sofosbuvir in human plasma has been established using ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS).

    Materials And Methods: Sofosbuvir d3 was used as an internal standard. Sofosbuvir and internal standard in plasma sample were extracted using ethyl acetate (liquid liquid extraction). Read More

    Pattern and consequences of cardiologic medications management for patients with elevated troponin I upon admission into an intensive care unit not linked to type 1 acute myocardial infarction: A prospective observational cohort study.
    Ann Pharm Fr 2017 Jul 26;75(4):285-293. Epub 2017 Apr 26.
    Réanimation polyvalente, centre hospitalier universitaire Félix-Guyon, Bellepierre, allée des Topazes, 97405 Saint-Denis, Reunion. Electronic address:
    Objectives: No recommendations are currently available to help the clinician with the pharmacological management of intensive care unit (ICU) patients with elevated cardiac troponin (cTn) not linked to type 1 AMI. The aim of this study was to evaluate the pattern of cardiologic medications for patients with elevated cTnI in ICU not link to type 1 AMI and their effects on in-hospital mortality.

    Material And Methods: A prospective observational cohort study conducted in two ICU units. Read More

    [Which useful Apps are installed on my smartphone as a clinical pharmacist?]
    Ann Pharm Fr 2017 Jul 8;75(4):309-317. Epub 2017 Apr 8.
    Centre national hospitalier d'information sur le médicament, 75/77, rue du Père-Corentin, CS 91425, 75993 Paris cedex 14, France; CNRS/TIMC-IMAG UMR5525/Themas, université Grenoble Alpes, 38041 Grenoble, France; Pôle Pharmacie, CHU Grenoble Alpes, Grenoble, France.
    Since the advent of PDAs (Personal Digital Assistants), smartphones and Apps have been widely adopted by medical professionals. This craze has increased since 2007 and the first generation iPhone. In this context, 3 questions emerged for the pharmacist that we studied in this review: (1) What Apps are available for practice and how to find them? (2) What is useful for practice? (3) What precautions should be taken? Read More

    Current trends in vasopressor use to the operating room: A pharmacoepidemiologic study in French teaching and military hospitals.
    Ann Pharm Fr 2017 Jul 24;75(4):276-284. Epub 2017 Mar 24.
    Délégation à la recherche clinique et a l'innovation, cellule innovation, UMR-CNRS 5510/MATEIS, hospices civils de Lyon, 69500 Bron, France.
    Objectives: Phenylephrine, ephedrine and norepinephrine are the vasopressors most commonly used in the operating room to treat anaesthesia-induced hypotension. Two new diluted forms of phenylephrine were released in 2011 (500μg/10mL and 500μg/5mL). We initiated a study to evaluate trends in the use of vasopressors in the operating room in French hospitals over the period 2011-2014. Read More

    [Economic evaluation of medical devices not included in the French list of products and services qualifying for reimbursement: Example of biologic meshes].
    Ann Pharm Fr 2017 Sep 16;75(5):398-407. Epub 2017 Mar 16.
    Cellule innovation/UMR-CNRS 5510/Mateis, délégation à la recherche clinique et à l'innovation, hospices civils de Lyon, 69500 Bron, France.
    Objectives: To present a method aimed to evaluate the economic impact associated with the use of medical devices (DM) not reimbursed in addition to diagnosis related groups (DRGs) tariffs using the example of biological meshes for parietal reinforcement.

    Methods: In this multicenter retrospective cohort study, we included all patients who received a biological mesh between January 2010-April 2014 (University hospitals of Saint-Étienne, France) or between January 2010-March 2015 (Lyon University hospitals, France). Measured costs associated with biologic meshes were compared to those of the "Étude nationale des coûts à méthodologie commune" (2012) to weigh the economic impact of biologic meshes with the French DRGs costs. Read More

    [Decontamination of organophosphorus compounds: Towards new alternatives].
    Ann Pharm Fr 2017 May 6;75(3):209-226. Epub 2017 Mar 6.
    Inserm, CNRS, IRD, URMITE, Aix Marseille université, Marseille, France; Gene&GreenTK, faculté de médecine, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France. Electronic address:
    Organophosphorus coumpounds (OP) are toxic chemicals mainly used for agricultural purpose such as insecticides and were also developed and used as warfare nerve agents. OP are inhibitors of acetylcholinesterase, a key enzyme involved in the regulation of the central nervous system. Chemical, physical and biological approaches have been considered to decontaminate OP. Read More

    Toxicodynetics in nordiazepam and oxazepam overdoses.
    Ann Pharm Fr 2017 May 24;75(3):163-171. Epub 2017 Feb 24.
    UMR 8257 cognitive action group, Paris Descartes university, 45, rue des Saints-Pères, 75270 Paris cedex 06, France; Paris poison control centre, hôpital Fernand-Widal, 200, rue du Faubourg-Saint-Denis, 75010 Paris, France; Department of anesthesiology-intensive care, hôpital Necker, 149, rue de Sèvres, 75015 Paris, France; Paris Diderot university, Paris, France. Electronic address:
    Objectives: Toxicodynetics aims at defining the time-course of major clinical events in drug overdose. We report the toxicodynetics in mono-intoxications with oxazepam and nordiazepam.

    Methods: Cases of oxazepam or nordiazepam overdoses collected at the Paris poison control centre from 1999 to 2014 on the basis of self-report. Read More

    A survey of pharmacists' knowledge and views of biosimilars in Quebec and France.
    Ann Pharm Fr 2017 Jul 23;75(4):267-275. Epub 2017 Feb 23.
    Pharmacy Practice Research Unit, Pharmacy department, CHU Sainte-Justine, 3175, chemin de la Côte Sainte-Catherine, H3T 1C5 Montréal, QC, Canada; Faculty of pharmacy, Université de Montréal, 2900, boulevard Édouard-Montpetit, H3T 1J4 Montréal, QC, Canada. Electronic address:
    Objective: The objective of this study was to survey pharmacists' knowledge and views of biosimilars in Quebec and France.

    Methods: An online and anonymous survey was conducted. The survey was divided into two parts including: (1) ten multiple choice questions on main characteristics that distinguish biosimilars from generic drugs; (2) fifteen statements on biosimilars key issues (interchangeability, immunogenicity risk management…). Read More

    Physical stability of highly concentrated injectable drugs solutions used in intensive care units.
    Ann Pharm Fr 2017 May 13;75(3):185-188. Epub 2017 Feb 13.
    Medical Laboratory, CHU Dinant Godinne, UCL Namur, avenue Therasse, 1, 5530 Yvoir, Belgium; Drug Stability Research Group, CHU Dinant Godinne, UCL Namur, avenue Therasse, 1, 5530 Yvoir, Belgium.
    Background: The intensive care department of the institution use drug solutions within higher concentration to avoid fluid overload. The purpose of the study is to prove the physical stability of different injectable drugs within high concentration (amiodarone 25mg/mL, isosorbide 0.60mg/mL, lorazepam 0. Read More

    A case report of rare palmoplantar keratosis and nail dystrophy with imatinib.
    Ann Pharm Fr 2017 May 9;75(3):172-175. Epub 2017 Feb 9.
    Service of pharmacy, National institute of oncology, 10170 Rabat, Morocco.
    A 48-year-old woman developed palmoplantar hyperkeratosis during treatment with imatinib (400mg/day) for treatment of chronic myeloid leukemia. After 5months of treatment, she developed plantar lesions with yellow-brownish plaques and palmar desquamations. The skin biopsy has eliminated psoriasis. Read More

    [Management and prevention of cow's milk protein allergy: Contribution of community pharmacists].
    Ann Pharm Fr 2017 May 8;75(3):236-244. Epub 2017 Feb 8.
    UFR des sciences pharmaceutiques, université de Caen Normandie, 14000 Caen, France; UMR 1086 Inserm « cancers et préventions », centre François-Baclesse, avenue du général-Harris, 14076 Caen cedex 05, France.
    Cow's milk protein allergy (CMPA) is a public health issue in children whose quality of life is strongly affected. The objective of this article is to review the present state of knowledge on the CMPA, and highlight some emerging alternatives in its management and in its prevention. Good knowledge in the appropriate infant formula, exclusion diets, the handling of the emergency treatment thanks to the use of epinephrine auto-injector pens, the use of personalized care project and accessibility to allergic patients' association are factors that secure the management. Read More

    Validated stability-indicating HPLC-DAD method for determination of the recently approved hepatitis C antiviral agent daclatasvir.
    Ann Pharm Fr 2017 May 8;75(3):176-184. Epub 2017 Feb 8.
    Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah, 21521 Alexandria, Egypt. Electronic address:
    A comprehensive stability indicating HPLC with diode array detection method was developed for the determination of the recently approved antiviral drug daclatasvir dihydrochloride (DCV) which is used for the treatment of chronic Hepatitis C Virus (HCV) genotype 3 infection. Effective chromatographic separation was achieved using Waters C8 column (4.6×250mm, 5μm particle size) with isocratic elution of the mobile phase composed of mixed phosphate buffer pH 2. Read More

    [Patient's own medications in a Swiss regional hospital: where are we and where should we go?]
    Ann Pharm Fr 2017 Jul 4;75(4):294-301. Epub 2017 Feb 4.
    Service de pharmacie, institut central des hôpitaux (ICH), hôpital du Valais, avenue du Grand-Champsec 86, 1951 Sion, Suisse. Electronic address:
    Objective: The use of patient's own medications (POMs) during inpatient admissions may represent a risk if not adequately supervised. The objective of this work was: (i) to assess the management of POMs in our hospital, and (ii) to identify actions to assure this practice.

    Methods: A questionnaire survey was conducted among caregivers of the medical, surgery and geriatric units of a Swiss regional hospital. Read More

    The topological phase diagram of cimetidine: A case of overall monotropy.
    Ann Pharm Fr 2017 Mar 1;75(2):89-94. Epub 2017 Feb 1.
    Caracterisation des matériaux moléculaires à activité thérapeutique (CAMMAT), faculté de pharmacie, université Paris-Descartes, 4, avenue de l'observatoire, 75006 Paris, France. Electronic address:
    Cimetidine is a histamine H2-receptor antagonist used against peptic ulcers. It is known to exhibit crystalline polymorphism. Forms A and D melt within 0. Read More

    [Retrospective study of the assessment and management of benzodiazepine withdrawal syndrome in hospital between 2000 and 2015].
    Ann Pharm Fr 2017 May 22;75(3):196-208. Epub 2016 Dec 22.
    Département de médecine interne, gériatrie, thérapeutique, CHU de Rouen, hôpital Saint-Julien, 2, rue Danton, 76141 Le Petit-Quevilly, France. Electronic address:
    Introduction: Benzodiazepines are prescribed in many indications and are provider of adverse effects in case of abrupt withdrawal or poorly framed. Withdrawal rules are established by the High Authority for Health.

    Methods: To evaluate the diagnostic and therapeutic modalities of the benzodiazepine withdrawal syndrome, we performed a retrospective single-center study at the University Hospital of Reims, between January 2000 and May 2015, in patients with a withdrawal syndrome following hospital coding. Read More

    Development and efficacy assessments of tea seed oil makeup remover.
    Ann Pharm Fr 2017 May 14;75(3):189-195. Epub 2016 Dec 14.
    School of Cosmetic Science, Mae Fah Luang University, 333, Tasud Muang, 57100 Chiang Rai, Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, 333, Tasud Muang, 57100 Chiang Rai, Thailand. Electronic address:
    Introduction: The efficacy of tea seed oil to clean foundation and eyeliner was evaluated. The safe and efficient tea seed oil makeup remover was developed.

    Materials And Methods: In vitro cleansing efficacy of makeup remover was UV-spectrophotometric validated. Read More

    [Data regarding the roles and impact of pharmaceutical activities: Quantitative and qualitative study with four groups of experts].
    Ann Pharm Fr 2017 Mar 14;75(2):152-162. Epub 2016 Nov 14.
    Unité de recherche en pratique pharmaceutique, département de pharmacie, CHU Sainte-Justine, 3175, chemin de la Côte-Sainte-Catherine, Montréal, Québec H3T 1C5, Canada; Faculté de pharmacie, université de Montréal, succursale centre-ville, 6128 Montréal, Québec H3C 3J7, Canada. Electronic address:
    Objectives: The use of scientific data about the roles and the impact of pharmacists is suboptimal. The objective is to evaluate the opinion and attitude of expert pharmacists on the measurement of indicators for the pharmaceuticals activities, sharing and appropriation of scientific knowledge and the place of the website "Impact Pharmacie".

    Methods: This is a descriptive cross-sectional study. Read More

    Antioxidant activity and total phenolic and flavonoids content variations of leaves extracts of white Horehound (Marrubium vulgare Linné) from three geographical origins.
    Ann Pharm Fr 2016 Nov 21;74(6):453-462. Epub 2016 Aug 21.
    Laboratory of vegetal biodiversity: conservation and valorization, faculty of life and natural sciences, Djillali Liabes university, 22000 Sidi Bel-Abbes, Algeria.
    Objectifs: To elucidate the effect of the sampling location of Marrubium vulgare L. leaves on phenolic contents and antioxidant proprieties of flavonoids extracts.

    Materials And Methods: M. Read More

    Publications presenting negative impacts of pharmacists.
    Ann Pharm Fr 2016 Nov 27;74(6):448-452. Epub 2016 Jul 27.
    Pharmacy department, CHU Sainte-Justine, 3175, Côte-Sainte-Catherine, Montréal, Quebec, Canada; Faculty of pharmacy, université de Montréal, Montréal, Québec, Canada. Electronic address:
    Objectives: The main objective was to evaluate the rate of publications with at least one indicator of the negative impact of clinical pharmaceutics activity.

    Methods: This is a descriptive and retrospective literature review. A literature search was conducted using Pubmed. Read More

    [Enzymes for disrupting bacterial communication, an alternative to antibiotics?]
    Ann Pharm Fr 2016 Nov 27;74(6):413-420. Epub 2016 Jul 27.
    IRD 198, Inserm 1095, URMITE, UM63, CNRS 7278, Aix Marseille université, 13385 Marseille cedex 05, France. Electronic address:
    Quorum sensing (QS) is used by bacteria to communicate and synchronize their actions according to the cell density. In this way, they produce and secrete in the surrounding environment small molecules dubbed autoinducers (AIs) that regulate the expression of certain genes. The phenotypic traits regulated by QS are diverse and include pathogenicity, biofilm formation or resistance to anti-microbial treatments. Read More

    Impact of pharmaceutical intervention on quality of life and coping strategies in patients with haematological malignancies.
    Ann Pharm Fr 2016 Nov 6;74(6):439-447. Epub 2016 May 6.
    Department of Pharmacy, University Hospital, 14, rue Gaffarel, 21000 Dijon, France; EA 4184, University of Burgundy, 21000 Dijon, France. Electronic address:
    Objectives: We conducted a prospective study approved by the local ethics committee to determine the impact of a pharmaceutical intervention (PI) on pain, fatigue, quality of life (QoL) and coping strategies in patients with HMs starting chemotherapy sessions.

    Material And Methods: Patients received either usual care (UC)+PI (PI group) or UC alone (UC group). They had to complete 2 questionnaires, QLQ-C30 and MAC 21, at 3 different time points: before starting the 1st chemotherapy session (T1), during the intercure (T2) and the day before starting the 2nd chemotherapy session (T3). Read More

    [Introduction of Health technology assessment at hospital].
    Ann Pharm Fr 2016 Nov 29;74(6):473-481. Epub 2016 Apr 29.
    Hôpital européen Georges-Pompidou, 75015 Paris, France. Electronic address:
    Introduction: The Medical Devices Committee (CODIMS) of the Assistance publique-Hôpitaux de Paris (AP-HP) is responsible for deciding whether innovative and costly sterile medical devices (SMD) should be adopted for the AP-HP network and for issuing recommendations on their proper use. The aim of this study was to qualify retrospectively the level of evidence of clinical studies used for the device evaluations by the CODIMS in 2012 and 2013 and to analyze the relationship between levels of evidence and decisions.

    Material And Method: Executive summaries written in 2012 and 2013 about studied SMD was analyzed and the level of evidence of clinical studies used was qualified in high/low levels of evidence according to the scale of Sackett et al. Read More

    [m-health in an age of e-health. Promises, challenges and liabilities].
    Ann Pharm Fr 2016 Nov 29;74(6):421-430. Epub 2016 Apr 29.
    Universités en droit pharmaceutique, Lille 2, Cabinet Simmons & Simmons, Lille, France. Electronic address:
    e-Health offers perspectives for patients, healthcare professionals and healthcare system, although this concept appears difficult to appreciate and to define. Uncertainties remain on the efficiency of these tools and their safety in particular with respect to personal data of the patients. Thus, we can observe the emergence of new categories of liabilities, not only with respect to the development of these new tools, but also regarding their distribution. Read More

    [Clinical pharmacist influence at hospital to prevent overdosed prescription of acetaminophen].
    Ann Pharm Fr 2016 Nov 25;74(6):482-488. Epub 2016 Apr 25.
    Service de pharmacie clinique, hôpitaux universitaires Paris-Centre, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
    Objectives: The recommended daily dose of acetaminophen is limited to 60mg/kg/day with a maximum of 3g daily dose in adults weighing less than 50kg or in patients undergoing certain risk factors. This study aimed at assessing the fulfillment of those recommendations and the possible impact on the liver dysfunction at supra-therapeutic doses of acetaminophen.

    Methods: This study was performed one day in 9 services. Read More

    Synthesis, antioxidant and analgesic activities of Schiff bases of 4-amino-1,2,4-triazole derivatives containing a pyrazole moiety.
    Ann Pharm Fr 2016 Nov 20;74(6):431-438. Epub 2016 Apr 20.
    Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
    A series of Schiff bases of 4-amino-1,2,4-triazole derivatives containing pyrazole (5a-h) were synthesized from condensation of 4-amino-5-(5-methyl-1H-pyrazol-3-yl)-4H-1,2,4-triazole-3-thiol (3) derivative with various aromatic aldehydes (4a-h). The structures of the synthesized compounds were elucidated by IR, (1)H NMR, (13)C NMR, and mass spectrometry. All the synthesized compounds (5a-h) were screened for their in vivo analgesic and in vitro antioxidant activities revealing significant analgesic and antioxidant properties. Read More

    [Medical homes and poles including pharmacists: An inventory].
    Ann Pharm Fr 2016 Nov 16;74(6):463-472. Epub 2016 Mar 16.
    Collège universitaire de médecine générale, université Claude-Bernard Lyon 1, 69373 Lyon cedex 08, France; Équipe HESPER, université de Lyon 1, 69373 Lyon cedex 08, France. Electronic address:
    Introduction: The current restructuring of primary healthcare aims toward the creation of coordinated practices, which involves new roles for pharmacists. The objectives of this study were to identify all the French multidisciplinary medical homes and poles (MMHs and MMPs) with pharmacists currently active, and to describe how they are organized and operate.

    Methods: This study focused on metropolitan MMHs and MMPs, active during the second semester of 2013, which include one or several pharmacists. Read More

    Spray-dried microparticles of glutathione and S-nitrosoglutathione based on Eudragit(®) FS 30D polymer.
    Ann Pharm Fr 2017 Mar 19;75(2):95-104. Epub 2016 Oct 19.
    Faculté de pharmacie, université de Lorraine, EA 3452/CITHEFOR-5, rue Albert-Lebrun, 54000 Nancy, France. Electronic address:
    Objective: In recent years, S-nitrosoglutathione has been proposed for the treatment of Crohn's disease to prevent mucosal barrier failure. In this paper, we report the formulation of spray dried microparticles of glutathione and S-nitrosoglutathione based on Eudragit(®) FS 30D polymer (i.e. Read More

    [Clinical pharmacy: Evaluation of physician's satisfactions and expectations in a French regional hospital].
    Ann Pharm Fr 2017 Mar 18;75(2):144-151. Epub 2016 Oct 18.
    Pharmacie à usage intérieur, France; Centre hospitalier Annecy-Genevois, 21, impasse des Ilettes, 74370 Metz-Tessy, France.
    Introduction: The purpose of the study was to evaluate physician's satisfaction with the clinical pharmacy activities in a French regional hospital.

    Methods: Data were collected by face-to-face interviews carried out by a public health intern with physicians from 14 different departments of medicine and surgery. A specifically designed questionnaire was used for this study. Read More

    [Medico-economic evaluation of therapeutic strategies at hospital: A systematic review of French studies].
    Ann Pharm Fr 2017 May 10;75(3):227-235. Epub 2016 Oct 10.
    Service pharmacie, hôpital d'instruction des armées Desgenettes, 108, boulevard Pinel, 69275 Lyon, France; Laboratoire parcours santé systémique, EAM 4129, université Claude-Bernard Lyon 1, quai des Célestins, 69002 Lyon, France.
    Introduction: Therapeutic innovation contributes to the increase of health care expenditures in France. Medico-economic evaluation has still a minor role in the decision-making for the registration of drugs and medical devices in hospitals. This study aimed to systematically review published works on medico-economic studies conducted within French hospitals. Read More

    Implementation of flu vaccination in community pharmacies: Understanding the barriers and enablers.
    Ann Pharm Fr 2017 Jan 4;75(1):9-16. Epub 2016 Oct 4.
    University of Nottingham, Boots UK Ltd, Thane Road, Nottingham, Nottingham, UK.
    Improving influenza vaccination coverage has been, and still remains a challenge internationally. There are now many examples where countries have pursued a pharmacist-led influenza vaccination service in order to enhance vaccination coverage of at-risk populations. England, Portugal and the United States are successful examples where their experience implementing this service can now be explored retrospectively and learnt from. Read More

    Benefits of pharmacist-led flu vaccination services in community pharmacy.
    Ann Pharm Fr 2017 Jan 4;75(1):3-8. Epub 2016 Oct 4.
    University of Nottingham, Boots UK Ltd, Thane Road Nottingham, UK.
    Seasonal influenza is a major cause of excess winter deaths and increased hospital admissions. There is a high level of economic burden associated with the infection. Although vaccination targets have been set to tackle this international issue, many countries struggle to reach these coverage targets for their at-risk populations using traditional delivery methods. Read More

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