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    4575 results match your criteria Annales Pharmaceutiques Francaises[Journal]

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    [Review of patient-specific instrumentation for total knee prosthesis].
    Ann Pharm Fr 2018 Feb 2. Epub 2018 Feb 2.
    Unité évaluation et achats des dispositifs médicaux, service évaluations pharmaceutiques et bon usage, Agence générale des équipements et produits de santé, Assistance publique-Hôpitaux de Paris, 75005 Paris, France.
    Objectives: Single use patient-specific instruments (PSI) for total knee prosthesis are introduced as a new alternative to conventional ancillaries and computer assisted surgery by improving implants positioning. An exhaustive review was carried out to identify their specific characteristics, with their advantages and disadvantages.

    Methods: Medical devices suppliers were consulted in 2015 for reviewing their PSI. Read More

    [Economic impact of centralization of chemotherapy preparation: Experience of the National institute of oncology of Rabat].
    Ann Pharm Fr 2018 Mar 13;76(2):147-153. Epub 2018 Feb 13.
    Service de pharmacie, Institut national d'oncologie, centre hospitalier Ibn-Sina de Rabat, 1000 Rabat, Maroc; Laboratoire de pharmacologie et de toxicologie, faculté de médecine et de pharmacie de Rabat, université Mohamed V, Rabat, Maroc.
    Introduction: Centralized preparation of anticancer drugs meets quality and safety objectives. Its economic interest has been the subject of several studies, with very heterogeneous methodological approaches.

    Objective: This study evaluates the economic impact of the centralization of the preparation of chemotherapy in the national institute of oncology of Rabat, the referral institute in the management of cancer in Morocco. Read More

    [Physicochemical stability of individualized parenteral nutrition in neonatal period].
    Ann Pharm Fr 2018 Mar 13;76(2):154-162. Epub 2018 Feb 13.
    Pédiatrie Néonatale et Réanimations, CHU de Dijon, 14, rue Gaffarel, 21079 Dijon cedex, France. Electronic address:
    Individualized parenteral nutrition is frequently used in neonatal period because of specific nutritional needs of preterm neonates which are not always covered by industrially produced parenteral nutrition. This review summarizes the risks of physicochemical instability associated with parenteral nutrition preparation in order to make recommendations to secure this mode of preparation. Read More

    [HEV and transfusion-recipient risk].
    Ann Pharm Fr 2018 Mar 1;76(2):89-96. Epub 2018 Feb 1.
    Laboratoire de virologie, centre national de référence virus des hépatites à transmission entérique (hépatites A et E), institut fédératif de biologie, CHU de Purpan, 330, avenue de Grande-Bretagne, TSA 40031, 31059 Toulouse, France; Inserm U1043/CNRS 5282, université Paul-Sabatier, centre de physiopathologie de Toulouse-Purpan, 31024 Toulouse cedex 03, France. Electronic address:
    HEV infections are mainly food- and water-borne but transfusion-transmission has occurred in both developing and developed countries. The infection is usually asymptomatic but it can lead to fulminant hepatitis in patients with underlying liver disease and pregnant women living in developing countries. It also causes chronic hepatitis E, with progressive fibrosis and cirrhosis, in approximately 60 % of immunocompromised patients infected with HEV genotype 3. Read More

    [Outcomes after a 2-year pharmaceutical care program for patients taking vitamin K antagonist therapy? Community pharmacist's perception].
    Ann Pharm Fr 2018 Mar 1;76(2):114-121. Epub 2018 Feb 1.
    Pôle pharmacie-pharmacovigilance, centre hospitalier universitaire de Reims, avenue du Général-Koening, 51100 Reims, France; UFR de pharmacie de Reims, UMR CNRS/URCA n(o) 7369 MEDyC, université de Reims Champagne-Ardenne, 51, rue Cognacq-Jay, 51100 Reims, France.
    Objectives: Since 2013 French community pharmacist are involved in pharmaceutical care program (PCP) for patients treated with vitamin K antagonist (VKA). While PCPs are now extending to other patient populations, we aimed to evaluate pharmacists' perception after 2-years implementation and leading of PCP.

    Methods: A prospective investigational survey from 1st August to 31st December, 2015 from 400 community pharmacies in Champagne-Ardenne Region. Read More

    [The role of pharmacist in a telemedicine collaboration in hemodialysis: Water bacteriological quality monitoring].
    Ann Pharm Fr 2018 Jan 17. Epub 2018 Jan 17.
    Centre hospitalier François-Dunan, boulevard Port-en-Bessin, BP 4216, 97500 Saint-Pierre-et-Miquelon, France.
    Objectives: In French health centers, the pharmacist is responsible for the quality of hemodialysis fluids. In an insular hospital, it is difficult to make bacteriological controls because of the lack of an environmental laboratory. Alternative choices of methods must be seek to facilitate water control and ensure the security of hemodialysis for patients. Read More

    Description and analysis of hospital pharmacies in Madagascar.
    Ann Pharm Fr 2018 Jan 15. Epub 2018 Jan 15.
    Grenoble Alpes University Hospital, 38043 Grenoble, France; School of Pharmacy of Grenoble Alpes, 38043 Grenoble, France; Techniques for Evaluation and Modeling of Health Actions (ThEMAS), Techniques for biomedical engineering and complexity management-informatics, mathematics and applications (TIMC-IMAG), National Institute of Sciences of the Universe-Research Unit 5525 (UMR CNRS), Grenoble Alpes University, 38043 Grenoble, France. Electronic address:
    Objective: Madagascar's health care system has operated without formal hospital pharmacies for more than two decades. The gradual integration of pharmacists in public hospitals since 2012 will allow the structuring of this field. This study was conducted to characterize the current situation regarding all aspects relating to the general functioning of hospital pharmacies and the services provided. Read More

    [3D printed medical devices and anatomical models: What kind of distribution and which uses in French hospitals?]
    Ann Pharm Fr 2018 Mar 23;76(2):139-146. Epub 2017 Dec 23.
    Service pharmacie, hôpital Européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France; Groupe de recherche et d'accueil en droit et économie de santé (GRADES), faculté de pharmacie, université Paris Sud, 5, rue Jean-Baptiste-Clément, 92290 Châtenay-Malabry, France. Electronic address:
    3D printing plays an increasingly important role in the medical sector and particularly in surgery. Nowadays, numerous manufacturers benefit from this technology to produce their medical devices and some hospitals have also purchased 3D printers. In this context, the aim of the present study was to study the distribution and the use of 3D printing in French hospitals in order to its main features in surgery. Read More

    Bacterial keratitis treated by strengthened antibiotic eye drops: An 18 months review of clinical cases and antibiotic susceptibilities.
    Ann Pharm Fr 2018 Mar 19;76(2):107-113. Epub 2017 Dec 19.
    Pharmacy department, University Hospital of Angers, 4, rue Larrey, 49933 Angers, France; University of Angers, MINT Inserm U1066/CNRS 6021, 4, rue Larrey, 49933 Angers, France. Electronic address:
    Purpose: To describe, in patients treated for infectious keratitis, the microorganisms identified and their antibiotic susceptibility over a period of 18 months.

    Method: Retrospective, descriptive, non-comparative study. Medical and biological data were extracted from the patients' file treated with strengthened antibiotic eye drops at Angers University Hospital between January 2015 and June 2016. Read More

    [Study of the reproducibility of the sterilization process and proposal of an sterilizer requalification protocol].
    Ann Pharm Fr 2018 Mar 6;76(2):129-138. Epub 2017 Dec 6.
    Service stérilisation, centre hospitalier universitaire d'Angers, 4, rue Larrey, 49933 Angers, France. Electronic address:
    Unlike EN 554, and since the publication of ISO 17665-1 standard, the user of autoclaves may use methods other than those indicated in the guidelines. Outsourcing the requalification of sterilizers by an external service provider and after observing from the previous requalification reports that the thermometric data seemed reproducible, we decided to propose and validate a validation method for the reproducibility of the sterilization process. This is to exempt from the study of the repeatability of the EN 554 standard in future requalifications. Read More

    [Perspective of the transition from reusable instruments to single use ancillary in orthopedic surgery].
    Ann Pharm Fr 2018 Mar 6;76(2):122-128. Epub 2017 Dec 6.
    Service évaluations pharmaceutiques et bon usage, agence générale des équipements et produits de santé, Assistance publique-Hôpitaux de Paris, 7, rue du Fer-à-Moulin, 75005 Paris, France.
    Objectives: Since 2009, single-use (SU) ancillaries for total knee arthroplasty (TKA) and total hip arthroplasty (THA) have been marketed to replace reusable ancillaries. The concept is not innovative but their use in orthopedics is still uncommon. An assessment has been done for the use of SU ancillary in Assistance publique-hôpitaux de Paris with the consequences for the patient, the surgeon and the hospital. Read More

    [Economic impact of etanercept and adalimumab biosimilars on hospitals scale covered by PharmAlp'Ain, a hospitals grouping of orders for health products].
    Ann Pharm Fr 2018 Jan 26;76(1):57-63. Epub 2017 Nov 26.
    Service évaluations pharmaceutiques et bon usage, AGEPS, AP-HP, Paris, France; Faculté de pharmacie de Paris, institut droit et santé, Inserm UMR S 1145, université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
    Objectives: To evaluate the economic impact of future prescriptions of etanercept and adalimumab biosimilars at the territorial scale covered by PharmAlp'Ain, a hospitals grouping of orders for health products.

    Methods: Determination of the number and status of patients (naive or in continuation of treatment) from the National Database "Datamart de Consommation Inter-Régimes" of health insurance, concerned by a dispensation in a pharmacy of etanercept or adalimumab in 2015. Calculation of potential savings in case of biosimilar requirements according to 3 hypotheses: 63% (rate observed in a previous study) of initiations are treated with biosimiliaries and the others by princeps (H); all initiations under biosimilars and continuation therapy with the princeps (H) or all patients are treated with biosimilars (H). Read More

    [Impact of an automated dispensing system for medical devices in cardiac surgery department].
    Ann Pharm Fr 2018 Jan 23;76(1):64-70. Epub 2017 Nov 23.
    Hôpital Henri-Mondor, 94000 Créteil, France.
    To secure medical devices' management, the implementation of automated dispensing system in surgical service has been realized. The objective of this study was to evaluate security, organizational and economic impact of installing automated dispensing system for medical devices (ASDM). The implementation took place in a cardiac surgery department. Read More

    Effect of surfactants and hydrophilic polymers on the stability of an antihypertensive drug candesartan cilexetil: Evaluation by HPLC.
    Ann Pharm Fr 2018 Jan 22;76(1):32-43. Epub 2017 Nov 22.
    National Institute of Pharmaceutical Education and Research-Ahmedabad, Opposite Air Force Station, Palaj, Gandhinagar 382355, Gujarat, India.
    Objectives: The objective of this study is to investigate the effect of surfactants (polysorbate 80 and sodium lauryl sulphate) and hydrophilic polymers (polyvinylpyrrolidone and polyethylene glycol 6000) on the stability of candesartan cilexetil under isothermal stress conditions (100°C, 48h).

    Methods: HPLC method was employed to evaluate the drug content and formation of degradation products in stress samples. Drug and degradation products were separated on Hypersil BDS C18 (250×4. Read More

    Studies on in-vitro hypoglycemic effects of root bark of Caesalpinia bonducella.
    Ann Pharm Fr 2018 Jan 14;76(1):44-49. Epub 2017 Nov 14.
    Department of pharmacognosy, Government college of pharmacy, Dist-Satara, 415124 Karad, Maharashtra, India. Electronic address:
    Objective: The present investigation was undertaken to assess the hypoglycemic potential of ethanolic (ECB) and aqueous extracts (ACB) of root bark of Caesalpinia bonducella using various in vitro techniques.

    Method: The ethanolic and aqueous extracts of root bark of C. bonducella were studied for their effects on glucose adsorption capacity, in vitro glucose diffusion, in-vitro amylolysis kinetics and glucose transport across membrane of yeast cells. Read More

    [Erratum to "Synthesis and binding affinity to human steroid hormone receptors of 3-phenoxy-4-hydroxycoumarins and 3-phenoxy-4-phenylcoumarins" [Ann. Pharm. Fr. 2017;75:455-462]].
    Ann Pharm Fr 2018 Jan 14;76(1):78. Epub 2017 Nov 14.
    Laboratoire de chimie thérapeutique, faculté de pharmacie de Paris Sud, 5, rue Jean-Baptiste-Clément, 92296 Chatenay-Malabry cedex, France. Electronic address:

    [Comparative profile of the use of filter needles in Quebec and France in healthcare facility].
    Ann Pharm Fr 2018 Jan 14;76(1):71-77. Epub 2017 Nov 14.
    Unité de recherche en pratique pharmaceutique, département de pharmacie, CHU Sainte-Justine, 3175, chemin de la Côte-Sainte-Catherine, H3T1C5 Montréal, Québec, Canada; Faculté de pharmacie, université de Montréal, Montréal, QC, Canada. Electronic address:
    Objectives: The manipulation of drugs from glass ampules can generate particles when the ampule is broken. Several authors recommend the use of filter needle to withdraw the drug content. The main objective is to establish an inventory of the use of filter needles and the perception of pharmacists in Quebec and in France. Read More

    PLGA-based monolithic filaments prepared by hot-melt extrusion: In-vitro comparative study.
    Ann Pharm Fr 2018 Mar 14;76(2):97-106. Epub 2017 Nov 14.
    Pharmaceutics department, Damanhour University, Egypt.
    To avoid frequent drug administration, PLGA-based monolithic filament-shaped implants were prepared. In this study, the effect of different formulation variables was studied, namely: type of PLGA (PLGA 502 and PLGA 503), type of drug (the lipophilic Prednisolone acetate, PA and the hydrophilic Propranolol Hydrochloride, PH) and drug loading (10 and 30% w/w). PLGA 503-based implants showed a lower water uptake, lower mass loss and erosion, slower drug release, and better mechanical properties and elasticity (P<0. Read More

    [City-hospital network and quality control of officinal preparations].
    Ann Pharm Fr 2017 Oct 13. Epub 2017 Oct 13.
    Service central de la qualité et de l'information pharmaceutiques, AP-HM, hôpital de la Conception, 147, boulevard Baille, 13005 Marseille, France; CNRS, UMR 7273, laboratoire de pharmaco-chimie radicalaire, faculté de pharmacie, institut de chimie radicalaire ICR, Aix-Marseille université, 27, boulevard Jean-Moulin, CS 30064, 13385 Marseille cedex 05, France. Electronic address:
    Objectives: In a hospital environment, the quality control of the hospital preparations allows to release homogeneous batches in a secure way. These controls are totally integrated into the process of production and can also, in certain cases, be realized for high-alert magistral preparations. In community pharmacy, these controls were not required, but the Agence régionale de santé (ARS) recently incited compounding community pharmacies to realize this type of analyses. Read More

    [Pharmaceutical record's use in drugs sales service: Analysis of five months of experimentation].
    Ann Pharm Fr 2018 Jan 19;76(1):50-56. Epub 2017 Sep 19.
    Service pharmacie et stérilisation, centre hospitalier Lucien-Hussel, montée du Docteur-Chapuis, 38200 Vienne, France.
    Objective: The pharmaceutical record integrated in the health insurance card is now exploitable by hospital pharmacists. The aim of this study is to assess the impact of pharmaceutical record's use in hospital drugs sales service and the relevance of this tool to secure the ambulatory dispensing of drugs.

    Method: All patients admitted in hospital drugs sales service between June and October 2016 were included. Read More

    Validated spectrophotometric and chromatographic methods for analysis of the recently approved hepatitis C antiviral combination ledipasvir and sofosbuvir.
    Ann Pharm Fr 2018 Jan 23;76(1):16-31. Epub 2017 Aug 23.
    Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah 21521, Alexandria, Egypt. Electronic address:
    This work describes five simple and reliable spectrophotometric and chromatographic methods for analysis of hepatitis C antiviral binary mixture of ledipasvir (LPV) and sofosbuvir (SBV). Method I is based on the use of Aand derivative spectrophotometry with the zero-crossing technique where LPV was determined using its AandD amplitudes at 324 and 338nm respectively, while SBV was determined by measuring theD amplitudes at 276nm. Method II involves the application of the ratio spectra derivative spectrophotometry. Read More

    [Use of a Delphi survey to assess the hospital economic impact of innovative products: The example of idarucizumab a dabigatran-specific reversal agent].
    Ann Pharm Fr 2017 Nov 14;75(6):480-488. Epub 2017 Aug 14.
    Service pharmacie, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France. Electronic address:
    Objectives: The economic impact of therapeutic innovations on the hospital patient management cannot be easily estimated. The objective of this study is to illustrate the use of a Delphi survey as a support tool to identify the changes following the use of idarucizumab in dabigatran-treated patients with uncontrolled/life-threatening bleeding or who required emergency surgery/urgent procedures.

    Methods: The Delphi questionnaires have been administrated to 8 emergency physicians or anesthetists from 6 different hospital centers. Read More

    [A comparative cost analysis of single-use versus reusable fiberoptic bronchoscopes: Is single-use fiberscope worth it?]
    Ann Pharm Fr 2017 Nov 14;75(6):473-479. Epub 2017 Aug 14.
    Service de pharmacie, centre hospitalier d'Ardèche-Nord, BP 119, rue du Bon-Pasteur, 07103 Annonay cedex, France.
    Objective: To present a minimization-cost analysis to compare reusable and single-use fiberscopes in a French health institution.

    Materials And Methods: The amortization cost assessment has been achieved over a period of five years, and took into account the acquisition and maintenance costs, as well as the costs related to disinfection of reusable fiberscopes. The cost of single-use fiberscopes was calculated according to its acquisition and elimination costs. Read More

    [Particulate contamination associated with the manipulation of drugs in glass ampules: A literature review].
    Ann Pharm Fr 2018 Jan 8;76(1):3-15. Epub 2017 Aug 8.
    Unité de recherche en pratique pharmaceutique, département de pharmacie, CHU Sainte-Justine, 3175, chemin de la Côte-Sainte-Catherine, H3T1C5 Montréal, Québec, Canada; Faculté de pharmacie, université de Montréal, Montréal, QC, Canada. Electronic address:
    Objectives: The manipulation of drugs from glass ampules can generate particles when the ampule is broken. Several authors recommend the use of filter needle to withdraw the drug content. The aim of this study is to make an assessment of the presence of particles during the manipulation of glass ampules and to discuss the current practices. Read More

    Multivariate statistical process control in product quality review assessment - A case study.
    Ann Pharm Fr 2017 Nov 7;75(6):446-454. Epub 2017 Aug 7.
    Pharmaceutical and toxicological analysis research team, laboratory of pharmacology and toxicology, faculty of medicine and pharmacy, university Mohammed V. Souissi, avenue Med Belarbi El Alaoui, BP 6203, 10000 Rabat, Morocco. Electronic address:
    According to the Food and Drug Administration and the European Good Manufacturing Practices (GMP) guidelines, Annual Product Review (APR) is a mandatory requirement in GMP. It consists of evaluating a large collection of qualitative or quantitative data in order to verify the consistency of an existing process. According to the Code of Federal Regulation Part 11 (21 CFR 211. Read More

    Extended stability of the rituximab biosimilar CT-P10 in its opened vials and after dilution and storage in polyolefin bags.
    Ann Pharm Fr 2017 Nov 4;75(6):420-435. Epub 2017 Aug 4.
    UPREC, service de pharmacie, groupe hospitalo-universitaire Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
    The stability of the rituximab biosimilar CT-P10, in 50mL vials at a concentration of 10mg/mL, and after dilution to final concentrations of 1 and 4mg/mL and storage in polyolefin bags at 4°C and 25°C was studied by several orthogonal and complementary methods. No significant change (as defined by a magnitude greater than the inter-batch variability) was observed, for each of the parameters characterizing physical and chemical stability studied, for the two concentrations and temperatures tested, or for any of the three batches tested. This implies that cold-chain rupture and exposure to room temperature up to 15 days both for vials and diluted bags have no deleterious consequence on the quality of the product. Read More

    [Targeted pharmacist-led medication order review in hospital: Assessment of a selection method for drug prescriptions].
    Ann Pharm Fr 2017 Nov 29;75(6):463-472. Epub 2017 Jul 29.
    Service pharmacie, centre hospitalier Lucien-Hussel, montée du Docteur-Chapuis, 38200 Vienne, France.
    Objectives: The aim of this study was to assess a selection method for drug prescriptions developed at the hospital level that allows to target pharmacist-led medication order review for at-risk patients and drugs.

    Methods: A one-month study has been conducted on all targeted medication orders in 19 care units. Selection criteria have been identified: biological criteria, alert medications and drug interactions. Read More

    A non-interventional retrospective cohort study of the interaction between methotrexate and proton pump inhibitors or aspirin.
    Ann Pharm Fr 2017 Sep 10;75(5):344-348. Epub 2017 Jul 10.
    Division of Clinical Pharmacy, OLVG, Oosterpark 9, 1090HM Amsterdam, Netherlands. Electronic address:
    Introduction: Methotrexate (MTX) is an antifolate drug, which is frequently used in the treatment of cancer. Proton pump inhibitors (PPIs) could delay the elimination of plasma MTX in high-dose MTX therapy by inhibition of tubular secretion, which could lead to MTX toxicity. However, the evidence of the clinical relevance of this drug-drug interaction is inconsistent. Read More

    Preparation and efficacy assessment of malva nut polysaccharide for skin hydrating products.
    Ann Pharm Fr 2017 Nov 8;75(6):436-445. Epub 2017 Jul 8.
    School of Cosmetic Science, Mae Fah Luang University, 57100 Chiang Rai, Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, 57100 Chiang Rai, Thailand.
    Introduction: Scaphium scaphigerum or malva nut has long been served in Chinese medicine. However, the use of this herb in modern health care applications has, to date, been rarely reported.

    Materials And Methods: Maceration of the herb in water afforded malva nut polysaccharide which was standardized. Read More

    [The roles and the impacts of pharmacists in the management of medical devices at the hospital: A literature review].
    Ann Pharm Fr 2017 Nov 27;75(6):409-419. Epub 2017 Jun 27.
    Unité de recherche en pratique pharmaceutique, département de pharmacie, CHU Sainte-Justine, 3175, chemin de la Côte-Sainte-Catherine, Montréal, QC, Canada, H3T 1C5; Faculté de pharmacie, université de Montréal, Montréal, QC, Canada. Electronic address:
    Objectives: Identify the training profile and the published evidences about the roles and the impacts of hospital pharmacists in medical devices.

    Methods: A literature review was conducted using Google, Google Scholar and Pubmed for 1990-2016 associated with a manual search conducted in three non-indexed pharmaceutical journals for 2000-2016.

    Results: The analysis of training programs available did not allow us to identify a specific training profile. Read More

    [Synthesis and binding affinity to human steroid hormone receptors of 3-phenoxy-4-hydroxycoumarins and 3-phenoxy-4-phenylcoumarins].
    Ann Pharm Fr 2017 Nov 12;75(6):455-462. Epub 2017 Jun 12.
    Laboratoire de chimie thérapeutique, faculté de pharmacie de Paris Sud, 5, rue Jean-Baptiste-Clément, 92296 Chatenay-Malabry cedex, France. Electronic address:
    The synthesis and the study of the binding affinity to human receptors of glucocorticoids, mineralcorticoids, androgens, estrogens and progesterone of 3-phenoxy-4-hydroxycoumarins and 3-phenoxy-4-phenylcoumarins were performed. It shows the absence of any binding affinity of all these derivatives to glucocorticoid and mineralcorticoid receptors and a non-selective binding affinity to androgen, oestrogen and progesterone receptors with 3-phenoxy-4-phényl-coumarins. Read More

    [Pharmacist's interview with type 2 diabetes: Development of a follow-up form].
    Ann Pharm Fr 2017 Sep 2;75(5):385-397. Epub 2017 Jun 2.
    Clermont université, université d'Auvergne, EA ACCEPPT, BP 10448, 63000 Clermont-Ferrand, France; Laboratoire de pharmacie galénique, Clermont université, université d'Auvergne, BP 10448, 63000 Clermont-Ferrand, France.
    Objectives: Type 2 diabetes is a major public health concern because of its prevalence, the severity of complications and the financial implications. Compliance and patient's autonomy in medications intake play key roles in the success of treatment. Pharmacists' interviews ensure an optimized and individual follow-up. Read More

    [The French medecine pricing committee].
    Ann Pharm Fr 2017 Sep 2;75(5):373-384. Epub 2017 Jun 2.
    Université Paris Dauphine, 75000 Paris, France. Electronic address:
    The French medicine pricing committee (CEPS) has to reconcile several major constraints, including optimal patient access to medicines and a good control of expenditures on reimbursable medicines. From 2013 to 2015, drug price decreases and discounts obtained by CEPS contributed more than € 5 billion to the balance of the health insurance accounts. As for price setting, there is a significant drop in the prices of medicines in France once they are registered for reimbursement. Read More

    Formulation development and evaluation of antimicrobial polyherbal gel.
    Ann Pharm Fr 2017 Sep 2;75(5):349-358. Epub 2017 Jun 2.
    Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, 415404 Kasegaon, Maharashtra, India.
    Objective: In the recent years, there has been a gradual revival of interest in the use of medicinal plants in developing countries because herbal medicines have been reported safe with minimal adverse side effect especially when compared with synthetic drugs.

    Method: In the present study we prepared gel formulations (formulations A and B) which comprised of ethanolic extract of Azadirachta indica, Curcuma longa, Allium sativum, Ocimum sactum, Cinnamomum zeylanicum nees and Tamarindus indica in a concentration of 0.1 and 0. Read More

    [Critical analysis of reference studies on aluminium-based adjuvants toxicokinetics].
    Ann Pharm Fr 2017 Jul 31;75(4):245-256. Epub 2017 May 31.
    Inserm U955 E10, centre expert de pathologie neuromusculaire, « Biologie du système neuromusculaire », hôpital Henri-Mondor, faculté de médecine, université Paris-Est-Créteil, 94010 Créteil, France. Electronic address:
    We reviewed the three reference toxicokinetic studies commonly used to suggest innocuity of aluminum (Al)-based adjuvants. A single experimental study was carried out using isotopicAl (Flarend et al., 1997). Read More

    [Direct mechanism of action in toxic myopathies].
    Ann Pharm Fr 2017 Sep 17;75(5):323-343. Epub 2017 May 17.
    Service de toxicologie, CHU Bab-El-Oued, rue Mohamed-Lamine-Debaghine, 16009 Alger, Algérie; Centre national de toxicologie, route du Petit-Staouali-Delly-Brahim, 16062 Alger, Algérie.
    Toxic myopathies are a large group of disorders generated by surrounding agents and characterized by structural and/or functional disturbances of muscles. The most recurrent are those induced by commonly used medications. Illicit drugs, environmental toxins from animals, vegetables, or produced by micro-organisms as well as chemical products commonly used are significant causes of such disorders. Read More

    [The French medecine pricing committee and the medicine economic policy: Rules and competences].
    Ann Pharm Fr 2017 Sep 15;75(5):359-372. Epub 2017 May 15.
    Paris sciences et lettres, université Paris Dauphine, 75000 Paris, France. Electronic address:
    The French medicine pricing committee (CEPS), a governmental and inter-institutional body exercises essential competences for the regulation of the economy of the reimbursable drugs in France. It provides a good example of administered price regulation. It also supervises the proper use of products (control of promotion, conventional control of sales volumes). Read More

    UPLC-MS/MS method for determination of sofosbuvir in human plasma.
    Ann Pharm Fr 2017 Jul 8;75(4):257-266. Epub 2017 May 8.
    Department of Pharmaceutical Analysis, St. Paul's College of Pharmacy, Turkayamjal, Hyderabad, TS, India.
    Introduction: A sensitive and rapid method for quantitation of Sofosbuvir in human plasma has been established using ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS).

    Materials And Methods: Sofosbuvir d3 was used as an internal standard. Sofosbuvir and internal standard in plasma sample were extracted using ethyl acetate (liquid liquid extraction). Read More

    Pattern and consequences of cardiologic medications management for patients with elevated troponin I upon admission into an intensive care unit not linked to type 1 acute myocardial infarction: A prospective observational cohort study.
    Ann Pharm Fr 2017 Jul 26;75(4):285-293. Epub 2017 Apr 26.
    Réanimation polyvalente, centre hospitalier universitaire Félix-Guyon, Bellepierre, allée des Topazes, 97405 Saint-Denis, Reunion. Electronic address:
    Objectives: No recommendations are currently available to help the clinician with the pharmacological management of intensive care unit (ICU) patients with elevated cardiac troponin (cTn) not linked to type 1 AMI. The aim of this study was to evaluate the pattern of cardiologic medications for patients with elevated cTnI in ICU not link to type 1 AMI and their effects on in-hospital mortality.

    Material And Methods: A prospective observational cohort study conducted in two ICU units. Read More

    [Which useful Apps are installed on my smartphone as a clinical pharmacist?]
    Ann Pharm Fr 2017 Jul 8;75(4):309-317. Epub 2017 Apr 8.
    Centre national hospitalier d'information sur le médicament, 75/77, rue du Père-Corentin, CS 91425, 75993 Paris cedex 14, France; CNRS/TIMC-IMAG UMR5525/Themas, université Grenoble Alpes, 38041 Grenoble, France; Pôle Pharmacie, CHU Grenoble Alpes, Grenoble, France.
    Since the advent of PDAs (Personal Digital Assistants), smartphones and Apps have been widely adopted by medical professionals. This craze has increased since 2007 and the first generation iPhone. In this context, 3 questions emerged for the pharmacist that we studied in this review: (1) What Apps are available for practice and how to find them? (2) What is useful for practice? (3) What precautions should be taken? Read More

    Current trends in vasopressor use to the operating room: A pharmacoepidemiologic study in French teaching and military hospitals.
    Ann Pharm Fr 2017 Jul 24;75(4):276-284. Epub 2017 Mar 24.
    Délégation à la recherche clinique et a l'innovation, cellule innovation, UMR-CNRS 5510/MATEIS, hospices civils de Lyon, 69500 Bron, France.
    Objectives: Phenylephrine, ephedrine and norepinephrine are the vasopressors most commonly used in the operating room to treat anaesthesia-induced hypotension. Two new diluted forms of phenylephrine were released in 2011 (500μg/10mL and 500μg/5mL). We initiated a study to evaluate trends in the use of vasopressors in the operating room in French hospitals over the period 2011-2014. Read More

    [Economic evaluation of medical devices not included in the French list of products and services qualifying for reimbursement: Example of biologic meshes].
    Ann Pharm Fr 2017 Sep 16;75(5):398-407. Epub 2017 Mar 16.
    Cellule innovation/UMR-CNRS 5510/Mateis, délégation à la recherche clinique et à l'innovation, hospices civils de Lyon, 69500 Bron, France.
    Objectives: To present a method aimed to evaluate the economic impact associated with the use of medical devices (DM) not reimbursed in addition to diagnosis related groups (DRGs) tariffs using the example of biological meshes for parietal reinforcement.

    Methods: In this multicenter retrospective cohort study, we included all patients who received a biological mesh between January 2010-April 2014 (University hospitals of Saint-Étienne, France) or between January 2010-March 2015 (Lyon University hospitals, France). Measured costs associated with biologic meshes were compared to those of the "Étude nationale des coûts à méthodologie commune" (2012) to weigh the economic impact of biologic meshes with the French DRGs costs. Read More

    [Decontamination of organophosphorus compounds: Towards new alternatives].
    Ann Pharm Fr 2017 May 6;75(3):209-226. Epub 2017 Mar 6.
    Inserm, CNRS, IRD, URMITE, Aix Marseille université, Marseille, France; Gene&GreenTK, faculté de médecine, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France. Electronic address:
    Organophosphorus coumpounds (OP) are toxic chemicals mainly used for agricultural purpose such as insecticides and were also developed and used as warfare nerve agents. OP are inhibitors of acetylcholinesterase, a key enzyme involved in the regulation of the central nervous system. Chemical, physical and biological approaches have been considered to decontaminate OP. Read More

    Toxicodynetics in nordiazepam and oxazepam overdoses.
    Ann Pharm Fr 2017 May 24;75(3):163-171. Epub 2017 Feb 24.
    UMR 8257 cognitive action group, Paris Descartes university, 45, rue des Saints-Pères, 75270 Paris cedex 06, France; Paris poison control centre, hôpital Fernand-Widal, 200, rue du Faubourg-Saint-Denis, 75010 Paris, France; Department of anesthesiology-intensive care, hôpital Necker, 149, rue de Sèvres, 75015 Paris, France; Paris Diderot university, Paris, France. Electronic address:
    Objectives: Toxicodynetics aims at defining the time-course of major clinical events in drug overdose. We report the toxicodynetics in mono-intoxications with oxazepam and nordiazepam.

    Methods: Cases of oxazepam or nordiazepam overdoses collected at the Paris poison control centre from 1999 to 2014 on the basis of self-report. Read More

    A survey of pharmacists' knowledge and views of biosimilars in Quebec and France.
    Ann Pharm Fr 2017 Jul 23;75(4):267-275. Epub 2017 Feb 23.
    Pharmacy Practice Research Unit, Pharmacy department, CHU Sainte-Justine, 3175, chemin de la Côte Sainte-Catherine, H3T 1C5 Montréal, QC, Canada; Faculty of pharmacy, Université de Montréal, 2900, boulevard Édouard-Montpetit, H3T 1J4 Montréal, QC, Canada. Electronic address:
    Objective: The objective of this study was to survey pharmacists' knowledge and views of biosimilars in Quebec and France.

    Methods: An online and anonymous survey was conducted. The survey was divided into two parts including: (1) ten multiple choice questions on main characteristics that distinguish biosimilars from generic drugs; (2) fifteen statements on biosimilars key issues (interchangeability, immunogenicity risk management…). Read More

    Physical stability of highly concentrated injectable drugs solutions used in intensive care units.
    Ann Pharm Fr 2017 May 13;75(3):185-188. Epub 2017 Feb 13.
    Medical Laboratory, CHU Dinant Godinne, UCL Namur, avenue Therasse, 1, 5530 Yvoir, Belgium; Drug Stability Research Group, CHU Dinant Godinne, UCL Namur, avenue Therasse, 1, 5530 Yvoir, Belgium.
    Background: The intensive care department of the institution use drug solutions within higher concentration to avoid fluid overload. The purpose of the study is to prove the physical stability of different injectable drugs within high concentration (amiodarone 25mg/mL, isosorbide 0.60mg/mL, lorazepam 0. Read More

    A case report of rare palmoplantar keratosis and nail dystrophy with imatinib.
    Ann Pharm Fr 2017 May 9;75(3):172-175. Epub 2017 Feb 9.
    Service of pharmacy, National institute of oncology, 10170 Rabat, Morocco.
    A 48-year-old woman developed palmoplantar hyperkeratosis during treatment with imatinib (400mg/day) for treatment of chronic myeloid leukemia. After 5months of treatment, she developed plantar lesions with yellow-brownish plaques and palmar desquamations. The skin biopsy has eliminated psoriasis. Read More

    [Management and prevention of cow's milk protein allergy: Contribution of community pharmacists].
    Ann Pharm Fr 2017 May 8;75(3):236-244. Epub 2017 Feb 8.
    UFR des sciences pharmaceutiques, université de Caen Normandie, 14000 Caen, France; UMR 1086 Inserm « cancers et préventions », centre François-Baclesse, avenue du général-Harris, 14076 Caen cedex 05, France.
    Cow's milk protein allergy (CMPA) is a public health issue in children whose quality of life is strongly affected. The objective of this article is to review the present state of knowledge on the CMPA, and highlight some emerging alternatives in its management and in its prevention. Good knowledge in the appropriate infant formula, exclusion diets, the handling of the emergency treatment thanks to the use of epinephrine auto-injector pens, the use of personalized care project and accessibility to allergic patients' association are factors that secure the management. Read More

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