Ann Chir 2006 Dec 19;131(10):626-30. Epub 2006 Jun 19.
Service de Chirurgie Viscérale et Vasculaire, Hôpital d'Instruction des Armées du Val-de-Grâce, 74, boulevard de Port-Royal, 75230 Paris cedex 05, France.
Non-functional paraganglioma have not clinical or biological characteristics, so that the diagnostic is most of the time delayed and made on the occasion of advanced abdominal tumor or symptomatic metastasis management. Hereditary forms, notably those with SDHB mutation, seem to have a poor prognosis. On the other hand, and on the oposite to sporadic forms, they are the only ones to benefit from genetic testing which make possible, if positive, an earlier diagnostic, before apparition of symptoms, recurrence or metastasis. Read More