11,386 results match your criteria Ann. Surg. Oncol.[Journal]


ASO Author Reflections: Which Patients with Colon Cancer Refuse Recommended Surgery?

Ann Surg Oncol 2020 Jul 1. Epub 2020 Jul 1.

Cooper Medical School of Rowan University, Camden, NJ, USA.

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http://dx.doi.org/10.1245/s10434-020-08798-8DOI Listing

Virtual Interviews for the Complex General Surgical Oncology Fellowship: The Dana-Farber/Partners Experience.

Ann Surg Oncol 2020 Jul 1. Epub 2020 Jul 1.

Division of Surgical Oncology, Department of Surgery, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1245/s10434-020-08778-yDOI Listing

ASO Author Reflections: Local Periostin Expression and Systemic Immunoinflammatory Measures in Esophageal Cancer: A Single-Center, Retrospective Study.

Ann Surg Oncol 2020 Jul 1. Epub 2020 Jul 1.

Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.

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http://dx.doi.org/10.1245/s10434-020-08779-xDOI Listing

Correlation Between Immunoinflammatory Measures and Periostin Expression in Esophageal Squamous Cell Carcinoma: A Single-Center, Retrospective Cohort Study.

Ann Surg Oncol 2020 Jul 1. Epub 2020 Jul 1.

Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.

Background: Immunoinflammatory measures such as the neutrophil-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), and the C-reactive protein (CRP)-albumin ratio (CAR) are useful prognostic measures in various malignancies. However, no study has investigated the correlation of these measures with microenvironmental inflammation. Periostin (POSTN), a small extracellular matrix protein, strongly associates with cancer microenvironmental inflammation. Read More

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http://dx.doi.org/10.1245/s10434-020-08765-3DOI Listing

Current Practice and Perceptions Regarding Cost Communication in Breast Cancer Reconstruction: Survey Results of the American Society of Plastic Surgeons.

Ann Surg Oncol 2020 Jul 1. Epub 2020 Jul 1.

Department of Plastic and Reconstructive Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Rising out-of-pocket costs (OOCs) are a major concern for breast cancer survivors. However, information on how plastic surgeons performing breast reconstruction (BR) perceive and communicate cost information is limited.

Methods: An electronic, anonymous survey eliciting plastic surgeons' attitudes and behaviors regarding BR cost communication was distributed to active American Society of Plastic Surgery members. Read More

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http://dx.doi.org/10.1245/s10434-020-08750-wDOI Listing

Is it Wise to Omit Sentinel Node Biopsy in Elderly Patients with Breast Cancer?

Ann Surg Oncol 2020 Jul 1. Epub 2020 Jul 1.

Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Background: The Society of Surgical Oncology's Choosing Wisely guidelines recommend against routine sentinel lymph node biopsy (SLNB) in clinically node-negative (cN0), hormone receptor (HR)-positive breast cancer patients aged ≥ 70 years. We examined the effect of SLNB on treatment and outcomes in this population.

Materials And Methods: A single-institution retrospective review of consecutive cN0 women ≥ 70 years of age who received SLNB was performed. Read More

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http://dx.doi.org/10.1245/s10434-020-08759-1DOI Listing

ASO Author Reflections: Accuracy of Maxillary and Mandibular Reconstruction Enhanced by Advances in Technology.

Ann Surg Oncol 2020 Jul 1. Epub 2020 Jul 1.

Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1245/s10434-020-08749-3DOI Listing

Transthoracic Versus Transhiatal Esophagectomy for Esophageal Cancer: A Nationwide Propensity Score-Matched Cohort Analysis.

Ann Surg Oncol 2020 Jun 30. Epub 2020 Jun 30.

Amsterdam UMC, Department of Surgery, Cancer Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.

Background: Chemoradiation followed by resection has been the standard therapy for resectable (cT1-4aN0-3M0) esophageal carcinoma in the Netherlands since 2010. The optimal surgical approach remains a matter of debate. Therefore, the purpose of this study was to compare the transhiatal and the transthoracic approach concerning morbidity, mortality and oncological quality. Read More

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http://dx.doi.org/10.1245/s10434-020-08760-8DOI Listing

ASO Author Reflections: Extraskeletal Myxoid Chondrosarcoma: A Rare Sarcoma Associated With Prolonged Survival.

Ann Surg Oncol 2020 Jun 30. Epub 2020 Jun 30.

Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

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http://dx.doi.org/10.1245/s10434-020-08774-2DOI Listing

Patient-Reported Outcome Measures for Post-mastectomy Breast Reconstruction: A Systematic Review of Development and Measurement Properties.

Ann Surg Oncol 2020 Jun 29. Epub 2020 Jun 29.

Bristol Centre for Surgical Research, Population Health Sciences, Bristol Medical School, Bristol, UK.

Background: Breast reconstruction (BR) is performed to improve outcomes for patients undergoing mastectomy. A recently developed core outcome set for BR includes six patient-reported outcomes that should be measured and reported in all future studies. It is vital that any instrument used to measure these outcomes as part of a core measurement set be robustly developed and validated so data are reliable and accurate. Read More

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http://dx.doi.org/10.1245/s10434-020-08736-8DOI Listing

ASO Author Reflection: Systemic Pharmacokinetics of Pressurized Intraperitoneal Aerosol Chemotherapy with Oxaliplatin in Patients with Colorectal Peritoneal Metastases.

Ann Surg Oncol 2020 Jun 29. Epub 2020 Jun 29.

Department of Clinical Pharmacy, Catharina Hospital, Michelangelolaan 2, 5623 EJ, Eindhoven, The Netherlands.

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http://dx.doi.org/10.1245/s10434-020-08780-4DOI Listing

Evidence-Based Follow-Up Schedules After Primary Cancer Treatment.

Ann Surg Oncol 2020 Jun 29. Epub 2020 Jun 29.

Melanoma Institute Australia, The University of Sydney, 40 Rocklands Road, North Sydney, NSW, 2060, Australia.

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http://dx.doi.org/10.1245/s10434-020-08768-0DOI Listing

Remote Home Monitoring of Older Surgical Cancer Patients: Perspective on Study Implementation and Feasibility.

Ann Surg Oncol 2020 Jun 29. Epub 2020 Jun 29.

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Remote home monitoring might fill the perceived surveillance gap after hospital discharge. However, it is unclear whether older oncologic patients will be able to use the required new digital technologies. The study aimed to assess the feasibility of postoperative remote home monitoring for this population. Read More

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http://dx.doi.org/10.1245/s10434-020-08705-1DOI Listing

Major Laparoscopic Versus Open Resection for Hepatocellular Carcinoma: A Propensity Score-Matched Analysis Based on Surgeons' Learning Curve.

Ann Surg Oncol 2020 Jun 29. Epub 2020 Jun 29.

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Background: Surgical complications for surgeons still in the learning phase of major laparoscopic liver resection (LLR) have been frequently observed. We aimed to compare perioperative and long-term outcomes of laparoscopic and open surgery based on the surgeons' learning curve for LLR after propensity score-matched (PSM) analysis.

Methods: This was a retrospective study of all patients with a histologic diagnosis of hepatocellular carcinoma who underwent major hepatectomy between January 2013 and December 2018. Read More

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http://dx.doi.org/10.1245/s10434-020-08764-4DOI Listing

Prognostic Implication of Postoperative Weight Loss After Esophagectomy for Esophageal Squamous Cell Cancer.

Ann Surg Oncol 2020 Jun 27. Epub 2020 Jun 27.

Department of Digestive Surgery, Osaka International Cancer Institute, Osaka, Japan.

Background: Preoperative weight loss in esophageal cancer is reported to be associated with a poor prognosis. However, the impact of postoperative weight loss on the prognosis of patients with esophageal cancer remains unclear.

Methods: This study included 186 patients with esophageal squamous cell carcinoma who underwent surgery between January 2012 and January 2015. Read More

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http://dx.doi.org/10.1245/s10434-020-08762-6DOI Listing

ASO Author Reflections: Identification of Intrahepatic Cholangiocarcinoma Clusters Using Machine Learning Techniques: Should Patients be Treated Differently?

Ann Surg Oncol 2020 Jun 26. Epub 2020 Jun 26.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA.

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http://dx.doi.org/10.1245/s10434-020-08697-yDOI Listing

Long-Term Safety of Delayed Surgery After Upfront Endoscopic Resection for Early Gastric Cancer: A Propensity Matched Study.

Ann Surg Oncol 2020 Jun 26. Epub 2020 Jun 26.

Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: When non-curative resection is confirmed after endoscopic resection (ER) of early gastric cancer (EGC), delayed surgery is recommended because it provides favorable survival outcomes. Long-term outcome after surgery of EGC with or without previous ER has not been evaluated.

Objective: The aim of this study was to compare the long-term oncologic safety between primary surgery and delayed surgery after ER. Read More

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http://dx.doi.org/10.1245/s10434-020-08769-zDOI Listing

Virtual Biobanking for Retroperitoneal Sarcoma: A Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) Initiative.

Ann Surg Oncol 2020 Jun 26. Epub 2020 Jun 26.

Surgical Oncology, Princess Margaret Cancer Centre, Mount Sinai Hospital, Department of Surgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1245/s10434-020-08775-1DOI Listing

The Landmark Series: Neoadjuvant Endocrine Therapy for Breast Cancer.

Ann Surg Oncol 2020 Jun 26. Epub 2020 Jun 26.

Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Patients with estrogen receptor (ER)-positive breast cancer generally do not have significant response to neoadjuvant chemotherapy. In these patients, neoadjuvant endocrine therapy (NET) is an alternative for those who may benefit from tumor downsizing prior to surgery. This article reviews clinical trials that have defined the role of NET. Read More

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http://dx.doi.org/10.1245/s10434-020-08530-6DOI Listing

ASO Author Reflections: Prediction of the Therapeutic Efficacy in Patients with Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma.

Ann Surg Oncol 2020 Jun 26. Epub 2020 Jun 26.

Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

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http://dx.doi.org/10.1245/s10434-020-08772-4DOI Listing

ASO Author Reflections: Minimally Invasive Ivor-Lewis Esophagectomy for Esophageal Cancer After Gastric Bypass.

Ann Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Department of Surgery, University of Florida College of Medicine, Jacksonville, FL, USA.

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http://dx.doi.org/10.1245/s10434-020-08756-4DOI Listing

Hepatectomy Combined with Diaphragmatic Resection for Hepatocellular Carcinoma with Diaphragmatic Involvement: A Propensity Score-Matched Analysis.

Ann Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

Purpose: We evaluated the short- and long-term surgical outcomes of hepatectomy combined with diaphragmatic resection for hepatocellular carcinoma (HCC) with diaphragmatic involvement.

Methods: We retrospectively reviewed the surgical outcomes of HCC patients with diaphragmatic resection (DR group) and HCC patients without diaphragmatic resection (non-DR group). We applied 1:1 propensity score matching (PSM) to these subjects. Read More

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http://dx.doi.org/10.1245/s10434-020-08754-6DOI Listing

Distal Pancreatectomy with Celiac Axis Resection (Modified Appleby Procedure) and Arterial Reconstruction for Locally Advanced Pancreatic Adenocarcinoma After FOLFIRINOX Chemotherapy and Chemoradiation Therapy.

Ann Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Department of Surgical Oncology, Institut du Cancer de Montpellier (ICM), Montpellier, France.

Background: Resectability of pancreatic carcinoma (PC) is directly linked to vascular extension (Tempero MA et al. in J Natl Compr Canc Netw 15(8):1028-1061, 2017. https://doi. Read More

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http://dx.doi.org/10.1245/s10434-020-08740-yDOI Listing

Editorial on "Simultaneous Ipsilateral Vascularized Lymph Node Transplantation and Contralateral Lymphovenous Anastomosis in Bilateral Different-Severities Extremity Lymphedema".

Ann Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Department of Plastic Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1245/s10434-020-08721-1DOI Listing

Routine Opioid Prescriptions Are Not Necessary After Breast Excisional Biopsy or Lumpectomy Procedures.

Ann Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Opioid analgesics are overprescribed after surgery. In August 2018, the authors replaced routine discharge opioid prescription with a nonsteroidal anti-inflammatory drug (NSAID) for patients who had a lumpectomy or excisional biopsy (lump/ex). This study compared patient-reported post-discharge pain scores for patients treated before and after the change in routine discharge medication. Read More

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http://dx.doi.org/10.1245/s10434-020-08651-yDOI Listing

ASO Author Reflections: Remote Home Monitoring After Surgery: Focus on Feasibility for Older Cancer Patients.

Ann Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1245/s10434-020-08751-9DOI Listing

Total Lesion Glycolysis Ratio in Positron Emission Tomography/Computed Tomography Images During Neoadjuvant Chemotherapy Can Predict Pathological Tumor Regression Grade and Prognosis in Patients with Locally Advanced Squamous Cell Carcinoma of the Esophagus.

Ann Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Background: The usefulness of quantitating tumor lesion glycolysis (TLG) from F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) findings as a tool for determining the effect of neoadjuvant chemotherapy (NAC) in esophageal squamous cell carcinoma (ESCC) has not yet been established.

Methods: The cohort of this retrospective study comprised 46 patients who had undergone NAC and subsequent esophagectomy for locally advanced ESCC between January 2008 and December 2017. PET/CT was conducted before and after NAC to assess its therapeutic effect. Read More

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http://dx.doi.org/10.1245/s10434-020-08738-6DOI Listing

Predictors for Survival in an International Cohort of Patients Undergoing Distal Pancreatectomy for Pancreatic Ductal Adenocarcinoma.

Ann Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Surgical factors, including resection of Gerota's fascia, R0-resection, and lymph node yield, may be associated with survival after distal pancreatectomy (DP) for pancreatic ductal adenocarcinoma (PDAC), but evidence from large multicenter studies is lacking. This study aimed to identify predictors for overall survival after DP for PDAC, especially those related to surgical technique.

Patients And Methods: Data from an international retrospective cohort including patients from 11 European countries and the USA who underwent DP for PDAC (2007-2015) were analyzed. Read More

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http://dx.doi.org/10.1245/s10434-020-08658-5DOI Listing

Completion Thyroidectomy is Less Common Following Updated 2015 American Thyroid Association Guidelines.

Ann Surg Oncol 2020 Jun 24. Epub 2020 Jun 24.

Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Background: The 2015 American Thyroid Association (ATA) guidelines recommended that low-risk, differentiated thyroid cancers (DTC) between 1 and 4 cm may be treated with thyroid lobectomy alone. We sought to determine the effect of these guideline changes on the rate of completion thyroidectomy (CT) for low-risk DTC and factors influencing surgical decision-making.

Methods: All patients from 2014 to 2018 who received an initial thyroid lobectomy at our institution with final pathology demonstrating DTC were included. Read More

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http://dx.doi.org/10.1245/s10434-020-08709-xDOI Listing

Metastatic Colorectal Cancers with Mismatch Repair Deficiency Result in Worse Survival Regardless of Peritoneal Metastases.

Ann Surg Oncol 2020 Jun 24. Epub 2020 Jun 24.

Department of Surgery, University of Chicago, Chicago, IL, USA.

Background: Mismatch-repair deficiency (dMMR) predicts worse chemoresponsiveness but better survival in early-stage colorectal adenocarcinoma. This study examined metastatic colorectal and appendix cancers with and without peritoneal metastasis (PM) in the National Cancer Database (NCDB), hypothesizing that dMMR tumors show better survival.

Methods: Stage 4 colon, rectum, and appendix cancers (2010-2016) were identified in the NCDB (including goblet cell carcinoids, excluding neuroendocrine tumors). Read More

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http://dx.doi.org/10.1245/s10434-020-08733-xDOI Listing

Development of Prediction Model Including MicroRNA Expression for Sentinel Lymph Node Metastasis in ER-Positive and HER2-Negative Breast Cancer.

Ann Surg Oncol 2020 Jun 24. Epub 2020 Jun 24.

Department of Breast and Endocrine Surgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan.

Background: The aim of our study is to find microRNAs (miRNAs) associated with sentinel lymph node metastasis (SLNM) and to develop a prediction model for SLNM in ER-positive and HER2-negative (ER+/HER2-) breast cancer.

Patients And Methods: In the present study, only ER+/HER2- primary breast cancer was considered. The discovery set for SLNM-associated miRNAs included 10 tumors with and 10 tumors without SLNM. Read More

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http://dx.doi.org/10.1245/s10434-020-08735-9DOI Listing

Impact of Perioperative Steroid Administration in Patients Undergoing Major Hepatectomy with Extrahepatic Bile Duct Resection: A Randomized Controlled Trial.

Ann Surg Oncol 2020 Jun 23. Epub 2020 Jun 23.

Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: To date, five randomized controlled trials have assessed the clinical benefit of perioperative steroid administration in hepatectomy; however, all of these studies involved a substantial number of 'minor' hepatectomies. The benefit of steroid administration for patients undergoing 'complex' hepatectomy, such as major hepatectomy with extrahepatic bile duct resection, is still unclear. This study aimed to evaluate the clinical benefit of perioperative steroid administration for complex major hepatectomy. Read More

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http://dx.doi.org/10.1245/s10434-020-08745-7DOI Listing

Radioactive Seed Versus Wire-Guided Localization for Ductal Carcinoma in Situ of the Breast: Comparable Resection Margins.

Ann Surg Oncol 2020 Jun 23. Epub 2020 Jun 23.

Department of Pathology, Erasmus MC Cancer Institute Rotterdam, Rotterdam, The Netherlands.

Background: There are currently two widely used methods for preoperative localization of ductal carcinoma in situ (DCIS) of the breast: wire-guided localization (WGL) and radioactive seed localization (RSL). Several studies compared these localization techniques in small cohorts.

Objective: The aim of this study was to compare the surgical resection margin status between RSL and WGL in a large national cohort of patients with DCIS. Read More

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http://dx.doi.org/10.1245/s10434-020-08744-8DOI Listing

Diaphragmatic Involvement Should Not Preclude Curative-Intent Surgical Resection for Hepatocellular Carcinoma.

Ann Surg Oncol 2020 Jun 23. Epub 2020 Jun 23.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, 320 W. 10th Avenue, M-260 Starling Loving Hall, Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1245/s10434-020-08757-3DOI Listing

ASO Author Reflections: Is Hepatectomy Plus Diaphragmatic Resection for Hepatocellular Carcinoma with Diaphragmatic Involvement Justified?

Ann Surg Oncol 2020 Jun 23. Epub 2020 Jun 23.

Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

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http://dx.doi.org/10.1245/s10434-020-08755-5DOI Listing

Three-Dimensionally Printed Patient-Specific Surgical Plates Increase Accuracy of Oncologic Head and Neck Reconstruction Versus Conventional Surgical Plates: A Comparative Study.

Ann Surg Oncol 2020 Jun 22. Epub 2020 Jun 22.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong SAR, China.

Background: Surgeons are pursuing accurate head and neck reconstruction to enhance aesthetic and functional outcomes after oncologic resection. This study aimed to investigate whether accuracy of head and neck reconstruction is improved with the use of three-dimensionally (3D)-printed patient-specific surgical plates compared with conventional plates.

Methods: In this comparative study, patients were prospectively recruited into the study group (3DJP16) with 3D-printed patient-specific surgical plates. Read More

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http://dx.doi.org/10.1245/s10434-020-08732-yDOI Listing

ASO Author Reflections: Assessing the Value of Primary Tumor Resection in Midgut Neuroendocrine Tumors with Liver-Only Metastases.

Ann Surg Oncol 2020 Jun 22. Epub 2020 Jun 22.

Division of Surgical Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1245/s10434-020-08753-7DOI Listing

Editorial Comment on: DPP9 Increases Chemoresistance and is an Indicator of Poor Prognosis in Colorectal Cancer.

Ann Surg Oncol 2020 Jun 22. Epub 2020 Jun 22.

Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.

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http://dx.doi.org/10.1245/s10434-020-08746-6DOI Listing

Extraskeletal Myxoid Chondrosarcoma with Molecularly Confirmed Diagnosis: A Multicenter Retrospective Study Within the Italian Sarcoma Group.

Ann Surg Oncol 2020 Jun 22. Epub 2020 Jun 22.

Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

Background: Extraskeletal myxoid chondrosarcoma (EMC) is a rare sarcoma of uncertain origin, marked by specific chromosomal translocations involving the NR4A3 gene, and usually characterized by an indolent course. Surgery (with or without radiotherapy) is the treatment of choice in localized disease. The treatment for advanced disease remains uncertain. Read More

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http://dx.doi.org/10.1245/s10434-020-08737-7DOI Listing

Systemic Pharmacokinetics of Oxaliplatin After Intraperitoneal Administration by Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC) in Patients with Unresectable Colorectal Peritoneal Metastases in the CRC-PIPAC Trial.

Ann Surg Oncol 2020 Jun 22. Epub 2020 Jun 22.

Department of Clinical Pharmacy, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ, Eindhoven, The Netherlands.

Background: Electrostatic pressurized intraperitoneal aerosol chemotherapy (ePIPAC) is a palliative treatment for unresectable peritoneal metastases from various primary cancers. However, little is known about the systemic pharmacokinetics of oxaliplatin after ePIPAC.

Methods: Twenty patients with unresectable colorectal peritoneal metastases were treated with repetitive ePIPAC monotherapy with oxaliplatin (92 mg/m) and a simultaneous intravenous bolus of leucovorin (20 mg/m) and 5-fluorouracil (400 mg/m). Read More

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http://dx.doi.org/10.1245/s10434-020-08743-9DOI Listing

ASO Author Reflections: Is Minimally Invasive Ivor-Lewis the Future of Esophagectomy?

Authors:
Samer A Naffouje

Ann Surg Oncol 2020 Jun 21. Epub 2020 Jun 21.

Department of General Surgery, University of Illinois Hospital and Health Sciences System, Chicago, IL, USA.

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http://dx.doi.org/10.1245/s10434-019-07772-3DOI Listing

Effects of Fibrin Sealant on Seroma Reduction for Patients with Breast Cancer Undergoing Axillary Dissection: Meta-Analysis of Randomized Controlled Trials.

Ann Surg Oncol 2020 Jun 20. Epub 2020 Jun 20.

Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Background: Seroma formation is common in patients with breast cancer after axillary dissection. Fibrin sealant, containing fibrinogen and thrombin, has been developed to improve wound healing. We conducted a systematic review and meta-analysis to evaluate the efficacy of fibrin sealants in reducing seroma among patients with breast cancer undergoing axillary dissection. Read More

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http://dx.doi.org/10.1245/s10434-020-08747-5DOI Listing

Significance of Frailty in Prognosis After Hepatectomy for Elderly Patients with Hepatocellular Carcinoma.

Ann Surg Oncol 2020 Jun 19. Epub 2020 Jun 19.

Department of Surgery, Tokushima University, Tokushima City, Tokushima, Japan.

Background: The concept of frailty becomes important for patients who undergo surgery in this recent aging society. The aim of this study is to investigate the frailty as a prognostic factor in elderly patients with hepatocellular carcinoma (HCC) who underwent hepatectomy.

Patients And Methods: A total of 92 patients over 75 years old who underwent hepatectomy were enrolled in this study. Read More

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http://dx.doi.org/10.1245/s10434-020-08742-wDOI Listing

Impact of Postoperative Chemotherapy on the Survival of Patients with High-Grade Gastroenteropancreatic Neuroendocrine Carcinoma.

Ann Surg Oncol 2020 Jun 18. Epub 2020 Jun 18.

Department of Surgery, Duke University Medical Center, Durham, NC, USA.

Background: This study aimed to determine whether postoperative chemotherapy is associated with a survival benefit for patients with poorly differentiated neuroendocrine carcinoma (NEC) of the stomach, small bowel, or pancreas.

Methods: Patients were identified in the National Cancer Database (NCDB) between 2004 and 2014. Inverse probability of treatment weighting (IPTW) was used to reduce selection bias. Read More

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http://dx.doi.org/10.1245/s10434-020-08730-0DOI Listing

Total Laparoscopic Uncut Roux-en-Y for Radical Distal Gastrectomy: An Interim Analysis of a Randomized, Controlled, Clinical Trial.

Ann Surg Oncol 2020 Jun 18. Epub 2020 Jun 18.

Department of Digestive Surgery, State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Background: The traditional Billroth II and Roux-en-Y anastomosis after laparoscopic distal gastrectomy for gastric cancer are associated with bile reflux gastritis and roux stasis syndrome, respectively. The uncut Roux-en-Y gastrojejunostomy can decrease the incidence of these complications by blocking the entry of bile and pancreatic juice into the residual stomach and retaining the impulses originating from the duodenum. The purpose of the present study was to compare the short-term outcomes of uncut Roux-en-Y (URY) and Billroth II combined Braun (BB) anastomosis. Read More

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http://dx.doi.org/10.1245/s10434-020-08710-4DOI Listing

Simultaneous Ipsilateral Vascularized Lymph Node Transplantation and Contralateral Lymphovenous Anastomosis in Bilateral Extremity Lymphedema with Different Severities.

Ann Surg Oncol 2020 Jun 18. Epub 2020 Jun 18.

Plastic and Reconstructive Surgery, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

Background: Extremity lymphedema can occur bilaterally with different severities on each side. The aim of this study is to investigate the treatment outcomes of such patients with bilateral extremity lymphedema of different severities.

Patients And Methods: Between 2013 and 2017, patients with bilateral extremity lymphedema of different severities according to the Taiwan Lymphoscintigraphy Staging (TLS) system were retrospectively reviewed. Read More

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http://dx.doi.org/10.1245/s10434-020-08720-2DOI Listing

A Phase II Trial of Cytoreduction, Gastrectomy, and Hyperthermic Intraperitoneal Perfusion with Chemotherapy for Patients with Gastric Cancer and Carcinomatosis or Positive Cytology.

Ann Surg Oncol 2020 Jun 17. Epub 2020 Jun 17.

Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.

Background: Current national guidelines do not include hyperthermic intraperitoneal chemoperfusion (HIPEC) as treatment for gastric cancer, and there are no completed clinical trials of cytoreduction, gastrectomy, and HIPEC from the US.

Methods: Patients with gastric adenocarcinoma and positive peritoneal cytology or carcinomatosis who had completed systemic chemotherapy and laparoscopic HIPEC underwent cytoreduction, gastrectomy, and HIPEC with 30 mg mitomycin C and 200 mg cisplatin. The primary endpoint was overall survival (OS), with a secondary endpoint of postoperative complications (NCT02891447). Read More

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http://dx.doi.org/10.1245/s10434-020-08739-5DOI Listing

Prediction Efficacy for Clinical Outcome of Prognostic Nutritional Index in Patients with Resectable Biliary Tract Cancer Depends on Sex and Obstructive Jaundice Status.

Ann Surg Oncol 2020 Jun 16. Epub 2020 Jun 16.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: The Prognostic Nutritional Index (PNI), a marker of nutritional status and systemic inflammation, is a proven prognostic biomarker in some cancers. The predictive value of PNI in biliary tract cancer (BTC) has not been established.

Objective: The aim of this study was to determine the relationship between the PNI and outcomes of resectable BTC. Read More

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http://dx.doi.org/10.1245/s10434-020-08728-8DOI Listing