9,993 results match your criteria Ann. Surg. Oncol.[Journal]


ASO Author Reflections: An Optimal Biological Model for Successful Drug Discovery.

Authors:
V Craig Jordan

Ann Surg Oncol 2019 Apr 17. Epub 2019 Apr 17.

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://link.springer.com/10.1245/s10434-019-07337-4
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http://dx.doi.org/10.1245/s10434-019-07337-4DOI Listing
April 2019
1 Read

Reply to Letter to the Editor Regarding "The Importance of Diagnosing Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) Based on the Defined Criteria".

Ann Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Otolaryngology - Head and Neck Surgery/Surgical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1245/s10434-019-07358-zDOI Listing

Multicenter Phase II Study of Intraoperative Radiotherapy of Early Breast Cancer: Ipsilateral Tumor Recurrence.

Ann Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

Background: We performed a multicenter phase II study on the efficacy and safety of intraoperative radiotherapy (IORT) as partial breast irradiation using multiple devices.

Methods: The primary endpoint was ipsilateral breast tumor recurrence (IBTR). Key inclusion criteria were T < 2. Read More

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http://dx.doi.org/10.1245/s10434-019-07350-7DOI Listing

ASO Author Reflections: Perioperative Genomic Profiles and Prognosis of Peripheral and Perihepatic Circulating Tumor DNA in Patients with Colorectal Liver Metastases.

Ann Surg Oncol 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Hepatopancreatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1245/s10434-019-07360-5DOI Listing

Oncologic Outcomes of Self-Expandable Metallic Stent as a Bridge to Surgery and Safety and Feasibility of Minimally Invasive Surgery for Acute Malignant Colonic Obstruction.

Ann Surg Oncol 2019 Apr 15. Epub 2019 Apr 15.

Division of Colon and Rectal Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Although self-expandable metal stents (SEMS) are widely used as a bridge to surgery (BTS) in patients with malignant colorectal cancer obstruction, there has been some debate about their effect on long-term oncological outcomes. Furthermore, data on the safety and feasibility of minimally invasive surgery (MIS) combined with stent placement are scarce. We aimed to determine the long-term oncological outcomes of SEMS as a BTS, and the short-term outcomes of SEMS used with minimally invasive colorectal surgery. Read More

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http://dx.doi.org/10.1245/s10434-019-07346-3DOI Listing
April 2019
1 Read

The Best Approach to Esophagectomy: Do We Know Yet?

Ann Surg Oncol 2019 Apr 15. Epub 2019 Apr 15.

Division of Surgical Oncology, Department of Surgery, SUNY Upstate Medical Center, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA.

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http://dx.doi.org/10.1245/s10434-019-07355-2DOI Listing

Salvage Surgery for Jejunal Necrosis After a Free Jejunal Transfer.

Ann Surg Oncol 2019 Apr 15. Epub 2019 Apr 15.

Department of Plastic and Reconstructive Surgery, Kagawa Rosai Hospital, Marugame, Kagawa, Japan.

Introduction: Given the few reports regarding the salvage methods for managing jejunal necrosis, finding candidates for a meta-analysis or systematic review is difficult. Thus, this study aimed to describe the interventions for jejunal necrosis and investigate important points relating to this condition.

Methods: The interventions used to treat free jejunal necrosis are external fistula formation with jejunal debridement, secondary reconstruction of the local site, and overall status improvement, and re-free jejunal transfer with removal of the necrotic jejunum. Read More

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http://dx.doi.org/10.1245/s10434-019-07348-1DOI Listing

Laparoscopic Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (L-CRS/HIPEC) for Perforated Low-Grade Appendiceal Mucinous Neoplasm (LAMN II).

Ann Surg Oncol 2019 Apr 15. Epub 2019 Apr 15.

The Christie NHS Foundation Trust, Colorectal and Peritoneal Oncology Centre, Manchester, UK.

Introduction: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is an established treatment for pseudomyxoma peritonei resulting from a perforated low-grade appendiceal mucinous neoplasm (LAMN II). In patients with localized disease, a laparoscopic procedure (L-CRS/HIPEC) can be undertaken.

Methods: This video demonstrates L-CRS/HIPEC in a 66-year-old male who had previously undergone an appendicectomy for an LAMN II lesion. Read More

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http://dx.doi.org/10.1245/s10434-019-07277-zDOI Listing
April 2019
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The Importance of Diagnosing Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) Based on the Defined Criteria.

Ann Surg Oncol 2019 Apr 15. Epub 2019 Apr 15.

Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil.

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http://dx.doi.org/10.1245/s10434-019-07354-3DOI Listing

Correction to: Postoperative Complications Independently Predict Cancer-Related Survival in Peritoneal Malignancies.

Ann Surg Oncol 2019 Apr 11. Epub 2019 Apr 11.

Division of Surgical Oncology, Koch Regional Perfusion Center, University of Pittsburgh, Pittsburgh, PA, USA.

In the original article, the Comprehensive Complication Index (CCI) was incorrectly identified as the Comprehensive Comorbidity Index. Wherever CCI appears, it refers to the Comprehensive Complication Index. Read More

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http://dx.doi.org/10.1245/s10434-019-07349-0DOI Listing
April 2019
1 Read

A Consensus Definition and Classification System of Oncoplastic Surgery Developed by the American Society of Breast Surgeons.

Ann Surg Oncol 2019 Apr 11. Epub 2019 Apr 11.

Avera Medical Group McHale Institute, Sioux Falls, SD, USA.

Background: Several definitions of oncoplastic surgery have been reported in the literature. In an effort to facilitate communication regarding oncoplastic surgery to patients, trainees, and among colleagues, the American Society of Breast Surgeons (ASBrS) aimed to create a consensus definition and classification system for oncoplastic surgery.

Methods: We performed a comprehensive literature search for oncoplastic surgery definitions using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

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http://link.springer.com/10.1245/s10434-019-07345-4
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http://dx.doi.org/10.1245/s10434-019-07345-4DOI Listing
April 2019
6 Reads

Clinical Implication of HER2 Status in Hormone Receptor-Positive Mucinous Breast Cancer.

Ann Surg Oncol 2019 Apr 11. Epub 2019 Apr 11.

Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

Purpose: Mucinous carcinoma (MC) is a rare breast cancer with favorable outcome. Unlike typical breast cancer, the current guidelines do not recommend chemotherapy or anti-human epidermal growth factor receptor 2 (HER2) therapy for hormone receptor (HR)-positive MC, regardless of HER2 status. We evaluated the prognostic implication of HER2 status in HR-positive MC. Read More

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http://dx.doi.org/10.1245/s10434-019-07332-9DOI Listing
April 2019
1 Read

Survival Benefit of Neoadjuvant Chemotherapy with S-1 Plus Docetaxel for Locally Advanced Gastric Cancer: A Propensity Score-Matched Analysis.

Ann Surg Oncol 2019 Apr 11. Epub 2019 Apr 11.

Department of Frontier Surgery, Chiba University, Chiba, Japan.

Background: Postoperative docetaxel plus S-1 (DS) chemotherapy is expected to be the standard therapeutic strategy for pStage III gastric cancer based on the results of the JACCRO GC-07 study. Neoadjuvant chemotherapy (NAC) is thought to have several advantages over adjuvant settings.

Objective: This study aimed to compare the efficacies of NAC DS and the surgery-first strategy for advanced gastric cancer patients with D2 gastrectomy. Read More

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http://dx.doi.org/10.1245/s10434-019-07299-7DOI Listing

Effects of Progressive Upper Limb Exercises and Muscle Relaxation Training on Upper Limb Function and Health-Related Quality of Life Following Surgery in Women with Breast Cancer: A Clinical Randomized Controlled Trial.

Ann Surg Oncol 2019 Apr 10. Epub 2019 Apr 10.

School of Nursing, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.

Objective: The aim of this study was to examine the effects of progressive upper limb exercises and muscle relaxation training (PULE-MRT) on upper limb function and health-related quality of life (HRQoL) following surgery in Chinese mainland women with breast cancer (BC).

Methods: Overall, 102 patients following surgery (i.e. Read More

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http://dx.doi.org/10.1245/s10434-019-07305-yDOI Listing
April 2019
1 Read
3.930 Impact Factor

Palliative Care and Symptom Burden in the Last Year of Life: A Population-Based Study of Patients with Gastrointestinal Cancer.

Ann Surg Oncol 2019 Apr 9. Epub 2019 Apr 9.

Department of Surgery, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Introduction: The symptom profile in cancer patients and the association between palliative care (PC) and symptoms has not been studied in the general population. We addressed these gaps in gastrointestinal (GI) cancer patients in the final year of life.

Methods: Patients dying of esophageal, gastric, colon, and anorectal cancers during 2003-2015 were identified. Read More

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http://link.springer.com/10.1245/s10434-019-07320-z
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http://dx.doi.org/10.1245/s10434-019-07320-zDOI Listing
April 2019
2 Reads

Correction to: Minimally Invasive Lymphadenectomy for Biliary Tumors: Stepwise Progress.

Ann Surg Oncol 2019 Apr 9. Epub 2019 Apr 9.

Division of Surgical Oncology, Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.

In the original article, Schelomo Marmor's last name is misspelled. It is correct as reflected here. Read More

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http://dx.doi.org/10.1245/s10434-019-07347-2DOI Listing

Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients.

Ann Surg Oncol 2019 Apr 8. Epub 2019 Apr 8.

Breast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Background: Intratumor heterogeneity implies that subpopulations of cancer cells that differ in genetic, phenotypic, or behavioral characteristics coexist in a single tumor (Ma in Breast Cancer Res Treat 162(1):39-48, 2017; Martelotto in Breast Cancer Res 16(3):210, 2014). Tumor heterogeneity drives progression, metastasis and treatment resistance, but its relationship with tumor infiltrating immune cells is a matter of debate, where some argue that tumors with high heterogeneity may generate neoantigens that attract immune cells, and others claim that immune cells provide selection pressure that shapes tumor heterogeneity (McGranahan et al. in Science 351(6280):1463-1469, 2016; McGranahan and Swanton in Cell 168(4):613-628, 2017). Read More

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http://dx.doi.org/10.1245/s10434-019-07338-3DOI Listing

Phase II Trial of Neoadjuvant Chemotherapy, Chemoradiotherapy, and Laparoscopic Surgery with Selective Lateral Node Dissection for Poor-Risk Low Rectal Cancer.

Ann Surg Oncol 2019 Apr 8. Epub 2019 Apr 8.

Department of Gastroenterological Oncology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.

Purpose: The aim of this study is to evaluate the safety and efficacy of induction modified 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus bevacizumab followed by S- 1-based chemoradiotherapy in magnetic resonance imaging (MRI)-defined poor-risk locally advanced low rectal cancer.

Patients And Methods: This was a prospective phase II trial at a single comprehensive cancer center. The primary endpoint was the pathological complete response (pCR) rate. Read More

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http://dx.doi.org/10.1245/s10434-019-07342-7DOI Listing

Role of the Interval from Completion of Neoadjuvant Therapy to Surgery in Postoperative Morbidity in Patients with Locally Advanced Rectal Cancer.

Ann Surg Oncol 2019 Apr 8. Epub 2019 Apr 8.

Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Increasing the interval from completion of neoadjuvant therapy to surgery beyond 8 weeks is associated with increased response of rectal cancer to neoadjuvant therapy. However, reports are conflicting on whether extending the time to surgery is associated with increased perioperative morbidity.

Methods: Patients who presented with a tumor within 15 cm of the anal verge in 2009-2015 were grouped according to the interval between completion of neoadjuvant therapy and surgery: < 8 weeks, 8-12 weeks, and 12-16 weeks. Read More

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http://dx.doi.org/10.1245/s10434-019-07340-9DOI Listing

Desmoplastic Small Round Cell Tumor: Long-Term Complications After Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.

Ann Surg Oncol 2019 Apr 8. Epub 2019 Apr 8.

Division of Surgical Oncology, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

Background: Desmoplastic small round cell tumor (DSRCT) is a rare intra-abdominal soft tissue sarcoma affecting adolescents and young adults. Cytoreduction, hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), and adjuvant radiotherapy may improve local control. We review our experience with patients who undergo CRS/HIPEC and adjuvant radiotherapy for DSRCT. Read More

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http://dx.doi.org/10.1245/s10434-019-07339-2DOI Listing
April 2019
1 Read

Robotic-Assisted Pelvic Lymphadenectomy for Metastatic Melanoma Results in Durable Oncologic Outcomes.

Ann Surg Oncol 2019 Apr 4. Epub 2019 Apr 4.

Department of Cutaneous Oncology, Moffitt Cancer Center and Research Institute, University of South Florida School of Medicine, 10920 N. McKinley Drive, Room 4123, Tampa, FL, 33612, USA.

Background: Robotic pelvic lymphadenectomy (rPLND) has been demonstrated to be a safe and effective minimally invasive approach for patients with metastatic melanoma to the iliac nodes. However, the long-term oncologic benefit of this procedure remains poorly defined.

Methods: A single-institutional study comparing perioperative outcomes and survival [recurrence-free (RFS) and overall survival (OS)] between rPLND and open PLND (oPLND) for metastatic melanoma was conducted. Read More

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http://dx.doi.org/10.1245/s10434-019-07333-8DOI Listing

Sidedness of Colorectal Cancer Impacts Risk of Second Primary Gastrointestinal Malignancy.

Ann Surg Oncol 2019 Apr 4. Epub 2019 Apr 4.

Division of Surgical Oncology, East Carolina University Brody School of Medicine, Greenville, NC, USA.

Introduction: A history of colorectal cancer (CRC) increases the risk of subsequent gastrointestinal (GI) cancer. Cancers of the right colon, left colon, and rectum differ according to molecular profiles, responses to treatment, and outcomes.

Objective: The purpose of this study was to determine if CRC location is associated with differential risk for secondary primary GI malignancy. Read More

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http://dx.doi.org/10.1245/s10434-019-07326-7DOI Listing
April 2019
1 Read

Longer Intervals from Neoadjuvant Therapy to Rectal Cancer Surgery: The Clock is Ticking….

Ann Surg Oncol 2019 Apr 3. Epub 2019 Apr 3.

Colorectal Surgery Division, University of São Paulo School of Medicine, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1245/s10434-019-07343-6DOI Listing

The Impact of Signet Ring Cell Differentiation on Outcome in Patients with Esophageal and Gastroesophageal Junction Adenocarcinoma.

Ann Surg Oncol 2019 Apr 2. Epub 2019 Apr 2.

Upper Gastrointestinal/Soft Tissue Unit, Princess Alexandra Hospital, Brisbane, QLD, Australia.

Background: Little is known about the association between signet ring cell (SRC) differentiation and response to neoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy (nCRT) in patients with esophageal and junctional adenocarcinoma (EAC). We aimed to assess if SRC differentiation is associated with survival and response to nCT or nCRT in patients with EAC.

Methods: Patients who underwent nCT and nCRT followed by surgery for EAC from 2000 until 2016 were identified from two institutional prospectively maintained databases. Read More

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http://dx.doi.org/10.1245/s10434-019-07322-xDOI Listing
April 2019
2 Reads

Germline Genetic Testing: What the Breast Surgeon Needs to Know.

Ann Surg Oncol 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA.

Purpose: The American Society of Breast Surgeons (ASBrS) sought to provide educational guidelines for breast surgeons on how to incorporate genetic information and genomics into their practice.

Methods: A comprehensive nonsystematic review was performed of selected peer-reviewed literature. The Genetics Working Group of the ASBrS convened to develop guideline recommendations. Read More

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http://dx.doi.org/10.1245/s10434-019-07341-8DOI Listing
April 2019
1 Read

Significance of Metabolic Tumor Volume at Baseline and Reduction of Mean Standardized Uptake Value in F-FDG-PET/CT Imaging for Predicting Pathological Complete Response in Breast Cancers Treated with Preoperative Chemotherapy.

Ann Surg Oncol 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgery, Division of Breast and Endocrine Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Background: The usefulness of F-fluorodeoxyglucose-positron emission tomography/computed tomography for evaluating the treatment efficacy of breast cancers is well-established; however, the predictive values of parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) remain unknown.

Methods: This study examined 199 breast cancers treated with primary systemic chemotherapy (PSC) followed by operation, and determined the values of maximum standardized uptake value (SUV), peak SUV (SUV), mean SUV (SUV), MTV, and TLG at baseline. Among these cases, data on early changes in these metabolic parameters in 70 breast cancers were also assessed. Read More

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http://dx.doi.org/10.1245/s10434-019-07325-8DOI Listing

Influence of Neoadjuvant Therapy on Poor Long-Term Outcomes of Postoperative Complications in Patients with Esophageal Squamous Cell Carcinoma: A Retrospective Cohort Study.

Ann Surg Oncol 2019 Apr 1. Epub 2019 Apr 1.

Department of Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Background: Postoperative complications have a negative impact on overall survival after esophagectomy because systemic inflammation may induce residual cancer cell growth. A solution that could suppress micrometastasis is neoadjuvant therapy; however, to date, no study has shown that neoadjuvant therapy suppresses proliferation of cancer cells due to postoperative complications after esophagectomy. The aim of this study is to investigate the influence of neoadjuvant therapy on poor long-term outcomes of postoperative complications in patients with esophageal carcinoma. Read More

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http://dx.doi.org/10.1245/s10434-019-07312-zDOI Listing
April 2019
3 Reads

Predictive Value of Body Mass Index for Short-Term Outcomes of Patients with Esophageal Cancer After Esophagectomy: A Meta-analysis.

Ann Surg Oncol 2019 Apr 1. Epub 2019 Apr 1.

Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China.

Background: The association between body mass index (BMI) and short-term outcomes after esophagectomy remains controversial.

Methods: A meticulous search for articles describing the association between BMI and perioperative outcomes after esophagectomy was conducted using PubMed, EMBASE, and the Cochrane Library. The study classified BMI according to the World Health Organization definitions and Asian-specific BMI cutoff values. Read More

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http://dx.doi.org/10.1245/s10434-019-07331-wDOI Listing

Thyroid Antibody Status is Associated with Central Lymph Node Metastases in Papillary Thyroid Carcinoma Patients with Hashimoto's Thyroiditis.

Ann Surg Oncol 2019 Apr 1. Epub 2019 Apr 1.

Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.

Objective: The aim of this study was to explore the impact of thyroid antibody status on central lymph node metastases (CLNM) in papillary thyroid carcinoma (PTC) patients with Hashimoto's thyroiditis (HT).

Methods: A retrospective analysis was performed on 346 PTC patients with HT who underwent thyroidectomy and ipsilateral central lymph node dissection (CLND). Histopathological characteristics of the tumor and serum levels of thyroid hormone, as well as antibodies, were collected and analyzed. Read More

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http://dx.doi.org/10.1245/s10434-019-07256-4DOI Listing
April 2019
1 Read
3.930 Impact Factor

Living Donor Liver Transplant for Hepatocellular Carcinoma.

Ann Surg Oncol 2019 Apr 1. Epub 2019 Apr 1.

Department of Surgery, Section of Abdominal Organ Transplant, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1245/s10434-019-07250-wDOI Listing
April 2019
2 Reads

Educating Surgical Oncology Providers on Perioperative Opioid Use: Results of a Departmental Survey on Perceptions of Opioid Needs and Prescribing Habits.

Ann Surg Oncol 2019 Apr 1. Epub 2019 Apr 1.

Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Patients undergoing oncologic surgery are at risk for persistent postoperative opioid use. As a quality improvement initiative, this study sought to characterize provider perceptions regarding opioid-prescribing after oncologic procedures.

Methods: Surgical oncology attending physicians, clinical fellows, and advanced practice providers (APPs) at a high-volume cancer center were surveyed before and after educational sessions focusing on the opioid epidemic with review of departmental data. Read More

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http://link.springer.com/10.1245/s10434-019-07321-y
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http://dx.doi.org/10.1245/s10434-019-07321-yDOI Listing
April 2019
7 Reads

Pure Laparoscopic Anatomical Segment V Resection Using the Extrafascial and Transfissural Glissonean Approach.

Ann Surg Oncol 2019 Mar 29. Epub 2019 Mar 29.

Department of Surgery, College of Medicine, Eulji University, Daejeon, Republic of Korea.

Background: The Glissonean approach is a widely used, effective technique for anatomical segmentectomy using an open or laparoscopic approach.14 In the extrafascial Glissonean approach, the deep tertiary branches of the right anterior portal pedicle may be difficult to dissect from the liver hilum.56 We present a pure laparoscopic anatomical segment V resection using the extrafascial and transfissural Glissonean approach. Read More

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http://dx.doi.org/10.1245/s10434-019-07324-9DOI Listing

Laparoscopic Complete Mesocolic Excision for Double Flexural Colon Cancers.

Ann Surg Oncol 2019 Mar 29. Epub 2019 Mar 29.

Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Laparoscopic complete mesocolic excision (CME) for hepatic or splenic flexural colon cancer is considered technically demanding. The double (hepatic and splenic) flexural colon cancers are rare, and the laparoscopic CME procedure for such disease is not standardized.

Methods: This video presents laparoscopic CME for double (hepatic and splenic) flexural colon cancers using a medial and cranial approach. Read More

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http://dx.doi.org/10.1245/s10434-019-07329-4DOI Listing

Colon Neuroendocrine Tumors: A New Lymph Node Staging Classification.

Ann Surg Oncol 2019 Mar 29. Epub 2019 Mar 29.

Department of Surgery, Division of Colorectal Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: The American Joint Commission on Cancer, the European Neuroendocrine Tumor Society, and the North American Neuroendocrine Tumor Society all classify colon neuroendocrine tumor (NET) nodal metastasis as N0 or N1. This binary classification does not allow for further prognostication by the total number of positive lymph nodes. This study aimed to evaluate whether the total number of positive lymph nodes affects the overall survival for patients with colon NET. Read More

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http://dx.doi.org/10.1245/s10434-019-07327-6DOI Listing

Compliance with Cancer Quality Measures Over Time and Their Association with Survival Outcomes: The Commission on Cancer's Experience with the Quality Measure Requiring at Least 12 Regional Lymph Nodes to be Removed and Analyzed with Colon Cancer Resections.

Ann Surg Oncol 2019 Mar 29. Epub 2019 Mar 29.

American College of Surgeons, Commission on Cancer, Chicago, IL, USA.

Background: Many quality measures in cancer care are process measures. The rates of compliance for these measures over time have not been well described, and the relationships between measure compliance and survival are not well understood.

Methods: The National Cancer Database, representing cancer registry data from approximately 1500 Commission on Cancer (CoC) cancer programs, was queried to determine the rates of compliance, with the CoC's colon cancer quality measure requiring 12 regional lymph nodes be removed at resection. Read More

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http://dx.doi.org/10.1245/s10434-019-07323-wDOI Listing

Should Utilization of Lymphadenectomy Vary According to Morphologic Subtype of Intrahepatic Cholangiocarcinoma?

Ann Surg Oncol 2019 Mar 29. Epub 2019 Mar 29.

Department of Surgery, The Urban Meyer III and Shelley Meyer Chair for Cancer Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Objective: We sought to evaluate the utilization of lymphadenectomy (LND) and the incidence of lymph node metastasis (LNM) among different morphologic types of intrahepatic cholangiocarcinoma (ICC).

Methods: Clinical data of patients undergoing curative-intent resection for ICC between 1990 and 2017 were collected and analyzed. The preoperative nodal status was evaluated by imaging studies, and the morphologic and lymph node (LN) status was collected on final pathology report. Read More

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http://dx.doi.org/10.1245/s10434-019-07336-5DOI Listing
March 2019
1 Read

The Value of Commission on Cancer Accreditation: Improving Survival Outcomes by Enhancing Compliance with Quality Measures.

Ann Surg Oncol 2019 Mar 29. Epub 2019 Mar 29.

Division of Surgical Oncology, Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1245/s10434-019-07335-6DOI Listing

Outcomes of Open Versus Minimally Invasive Ivor-Lewis Esophagectomy for Cancer: A Propensity-Score Matched Analysis of NSQIP Database.

Ann Surg Oncol 2019 Mar 29. Epub 2019 Mar 29.

Division of Surgical Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL, USA.

Introduction: We conducted this analysis to compare the outcomes of open transthoracic esophagectomy (OTTE) and minimally invasive transthoracic esophagectomy (MITTE) when performed for oncologic indications.

Methods: The NSQIP esophagectomy-targeted database during 2-year period was used. Only patients who underwent elective TTE for oncologic indications were included. Read More

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http://dx.doi.org/10.1245/s10434-019-07319-6DOI Listing
March 2019
3.930 Impact Factor

Long-Term Outcomes After Surgical Resection for Pleural Dissemination of Thymoma.

Ann Surg Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Japan.

Background: Cases of thymoma with pleural dissemination are occasionally encountered, and their management is difficult. Some reports have noted that surgical treatment for dissemination is effective, although the long-term results and clinical course details remain unclear. The current study investigated the short- and long-term outcomes of surgical resection of pleural dissemination. Read More

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http://dx.doi.org/10.1245/s10434-019-07330-xDOI Listing
March 2019
1 Read

Genetic and Immunohistochemical Studies Investigating the Histogenesis of Neuroendocrine and Carcinomatous Components of Combined Neuroendocrine Carcinoma.

Ann Surg Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.

Background: Lung combined neuroendocrine carcinomas (NECs) comprise NEC and non-NEC components, such as adenocarcinoma and squamous cell carcinoma. Mutation of epidermal growth factor receptor (EGFR) often is observed in non-NEC but is very rare in sporadic NEC, which almost always has p53 mutation. Therefore, we hypothesized the following research concept: mutation analysis of EGFR and p53 in each component of combined NEC tissues can provide important information on whether such components originate from the same tumor cells or incidentally arise as collision cancers. Read More

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http://dx.doi.org/10.1245/s10434-019-07268-0DOI Listing
March 2019
1 Read

Surgical Resection for Metastatic Tumors in the Pancreas: A Single-Center Experience and Systematic Review.

Ann Surg Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.

Background: Metastatic lesion to the pancreas accounts for approximately 2% of pancreatic neoplasms. There is no prospective, randomized or case-controlled study evaluating the role of pancreatic metastasectomy.

Methods: The PubMed, EMBASE, and Cochrane Library electronic databases were searched for studies published between January 1, 2001 and December 31, 2017. Read More

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http://dx.doi.org/10.1245/s10434-019-07258-2DOI Listing
March 2019
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3.930 Impact Factor

Minimally Invasive Lymphadenectomy for Biliary Tumors: Stepwise Progress.

Ann Surg Oncol 2019 Mar 27. Epub 2019 Mar 27.

Division of Surgical Oncology, Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.

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http://dx.doi.org/10.1245/s10434-019-07249-3DOI Listing

ASO Author Reflections: Pleuropulmonary Recurrence Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion for Appendiceal Pseudomyxoma Peritonei.

Ann Surg Oncol 2019 Mar 27. Epub 2019 Mar 27.

Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1245/s10434-019-07284-0DOI Listing

Development of a New Comorbidity Assessment Tool for Specific Prediction of Perioperative Mortality in Contemporary Patients Treated with Radical Cystectomy.

Ann Surg Oncol 2019 Mar 27. Epub 2019 Mar 27.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, QC, Canada.

Purpose: The Deyo adaptation of the Charlson comorbidity index (DaCCI), which relies on 17 comorbid condition groupings defined with 200 ICD-9-CM diagnostic codes, lacks specificity in the context of radical cystectomy (RC) for bladder cancer (BCa). We attempted to develop a new comorbidity assessment tool based on individual comorbid conditions and/or BCa manifestations for specific prediction of perioperative mortality after RC.

Methods: We relied on 7076 T1-T4 nonmetastatic BCa patients treated with RC between 2000 and 2009 in the SEER-Medicare linked database. Read More

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http://dx.doi.org/10.1245/s10434-019-07313-yDOI Listing
March 2019
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Preoperative Carcinoembryonic Antigen as a Poor Prognostic Factor in Stage I-III Colorectal Cancer After Curative-Intent Resection: A Propensity Score Matching Analysis.

Ann Surg Oncol 2019 Mar 26. Epub 2019 Mar 26.

Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.

Background: Preoperative carcinoembryonic antigen (CEA) has yet to be used as a prognostic or adjuvant chemotherapy factor for colorectal cancer (CRC).

Methods: This retrospective cohort study included all stage I-III CRC patients with different preoperative serum CEA levels (≤ 5, 5-10, and > 10 ng/ml) at a single center between 1995 and 2010. Propensity score matching was performed in a 1:1 ratio between the two elevated CEA groups (5-10 ng/ml and > 10 ng/ml) and in a 1:2 ratio between the elevated and non-elevated groups (≤ 5 ng/ml), with a caliper of 0. Read More

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http://dx.doi.org/10.1245/s10434-019-07184-3DOI Listing

Long-Term Oncologic Outcomes After Isolated Limb Infusion for Locoregionally Metastatic Melanoma: An International Multicenter Analysis.

Ann Surg Oncol 2019 Mar 25. Epub 2019 Mar 25.

Department of Cutaneous Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Background: Isolated limb infusion (ILI) is a minimally invasive procedure for delivering high-dose regional chemotherapy to patients with locally advanced or in-transit melanoma located on a limb. The current international multicenter study evaluated the perioperative and long-term oncologic outcomes for patients who underwent ILI for stage 3B or 3C melanoma.

Methods: Patients undergoing a first-time ILI for stage 3B or 3C melanoma (American Joint Committee on Cancer [AJCC] 7th ed) between 1992 and 2018 at five Australian and four United States of America (USA) tertiary referral centers were identified. Read More

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http://link.springer.com/10.1245/s10434-019-07288-w
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http://dx.doi.org/10.1245/s10434-019-07288-wDOI Listing
March 2019
11 Reads

The SERM Saga, Something from Nothing: American Cancer Society/SSO Basic Science Lecture.

Authors:
V Craig Jordan

Ann Surg Oncol 2019 Mar 25. Epub 2019 Mar 25.

Dallas/Fort Worth Living Legend Chair of Cancer Research, Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: The discovery of nonsteroidal antiestrogens created a new group of medicines looking for an application; however, at the time, cytotoxic chemotherapy was the modality of choice to treat all cancers. Antiestrogens were orphan drugs until 1971, with the passing of the National Cancer Act. This enabled laboratory innovations to aid patient care. Read More

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http://dx.doi.org/10.1245/s10434-019-07291-1DOI Listing
March 2019
2 Reads

False-Positive Results and Incidental Findings with Annual CT or PET/CT Surveillance in Asymptomatic Patients with Resected Stage III Melanoma.

Ann Surg Oncol 2019 Mar 25. Epub 2019 Mar 25.

Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.

Objective: The aim of this study was to quantify false-positive and incidental findings from annual surveillance imaging in asymptomatic, American Joint Committee on Cancer stage III melanoma patients.

Methods: This was a cohort study of patients treated at Melanoma Institute Australia (2000-2015) with baseline computed tomography (CT) or positron emission tomography (PET)/CT imaging and at least two annual surveillance scans. False-positives were defined as findings suspicious for melanoma recurrence that were not melanoma, confirmed by histopathology, subsequent imaging, or clinical follow-up, while incidental findings were defined as non-melanoma-related findings requiring further action. Read More

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http://link.springer.com/10.1245/s10434-019-07311-0
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http://dx.doi.org/10.1245/s10434-019-07311-0DOI Listing
March 2019
6 Reads

Can We Accurately Identify Peritoneal Metastases Based on Their Appearance? An Assessment of the Current Practice of Intraoperative Gastrointestinal Cancer Staging.

Ann Surg Oncol 2019 Mar 25. Epub 2019 Mar 25.

Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.

Background: Peritoneal lesions are common findings during operative abdominal cancer staging. The decision to perform biopsy is made subjectively by the surgeon, a practice the authors hypothesized to be imprecise. This study aimed to describe optical characteristics differentiating benign peritoneal lesions from peritoneal metastases. Read More

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http://dx.doi.org/10.1245/s10434-019-07292-0DOI Listing
March 2019
1 Read