49,000 results match your criteria Ann. N. Y. Acad. Sci.[Journal]


RNA stabilization in hyperthermophilic archaea.

Ann N Y Acad Sci 2019 Apr 17. Epub 2019 Apr 17.

Prokaryotic Small RNA Biology, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.

Analyses of the RNA metabolism of hyperthermophilic archaea highlight the efficiency of regulatory RNAs and RNA-guided processes at extreme temperatures. These organisms must overcome the intrinsic thermolability of RNAs. Elevated levels of RNA modifications and structured GC-rich regions are observed for many universal noncoding RNA families. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/nyas.14060
Publisher Site
http://dx.doi.org/10.1111/nyas.14060DOI Listing
April 2019
1 Read

Maternal hemoglobin concentrations across pregnancy and maternal and child health: a systematic review and meta-analysis.

Ann N Y Acad Sci 2019 Apr 17. Epub 2019 Apr 17.

Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany.

Maternal anemia is a well-recognized global health problem; however, there remain questions on specific hemoglobin (Hb) thresholds that predict health risk or protection for mother and child. We conducted a systematic review and meta-analysis to examine the associations of maternal Hb concentrations with a range of maternal and infant health outcomes, accounting for the timing of measurement (preconception, and first, second, and third trimesters), etiology of anemia, and cutoff category. The systematic review included 272 studies and the meta-analysis included 95 studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14093DOI Listing
April 2019
1 Read

Polymeric mesh and insulin-like growth factor 1 delivery enhance cell homing and graft-cartilage integration.

Ann N Y Acad Sci 2019 Apr;1442(1):138-152

Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York.

Cartilage injury, such as full-thickness lesions, predisposes patients to the premature development of osteoarthritis, a degenerative joint disease. While surgical management of cartilage lesions has improved, long-term clinical efficacy has stagnated, owing to the lack of hyaline cartilage regeneration and inadequate graft-host integration. This study tests the hypothesis that integration of cartilage grafts with native cartilage can be improved by enhancing the migration of chondrocytes across the graft-host interface via the release of chemotactic factor from a degradable polymeric mesh. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14054DOI Listing
April 2019
1 Read

Arts engagement and self-esteem in children: results from a propensity score matching analysis.

Ann N Y Acad Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of Behavioural Science and Health, University College London, London, UK.

Self-esteem is regarded as vital to children's social and cognitive development and emotional well-being. To date, a few studies have suggested that arts activities can improve self-esteem in young people. However, such studies mainly focused on small, nonrepresentative samples. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/nyas.14056
Publisher Site
http://dx.doi.org/10.1111/nyas.14056DOI Listing
April 2019
4 Reads

Small molecule targeting of RNA structures in neurological disorders.

Ann N Y Acad Sci 2019 Apr 9. Epub 2019 Apr 9.

Department of Chemistry, The Scripps Research Institute, Jupiter, Florida.

Aberrant RNA structure and function operate in neurological disease progression and severity. As RNA contributes to disease pathology in a complex fashion, that is, via various mechanisms, it has become an attractive therapeutic target for small molecules and oligonucleotides. In this review, we discuss the identification of RNA structures that cause or contribute to neurological diseases as well as recent progress toward the development of small molecules that target them, including small molecule modulators of pre-mRNA splicing and RNA repeat expansions that cause microsatellite disorders such as Huntington's disease and amyotrophic lateral sclerosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14051DOI Listing
April 2019
1 Read

What can we learn from the construction of in vitro replication systems?

Ann N Y Acad Sci 2019 Apr 8. Epub 2019 Apr 8.

Graduate School of Arts and Sciences and Komaba Institute for Science, The University of Tokyo, Tokyo, Japan.

Replication is a central function of living organisms. Several types of replication systems have been constructed in vitro from various molecules, including peptides, DNA, RNA, and proteins. In this review, I summarize the progress in the construction of replication systems over the past few decades and discuss what we can learn from their construction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14042DOI Listing

Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling.

Ann N Y Acad Sci 2019 Apr 7. Epub 2019 Apr 7.

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Methadone is a synthetic opioid used to treat opiate withdrawal and addiction. Studies have demonstrated the impact of methadone on seizure susceptibility. This study investigated the modulatory impacts of acute and subchronic (three times daily for 5 days) intraperitoneal methadone treatment on pentylenetetrazole-induced clonic seizure threshold (CST) in mice, as well as the involvement of the nitric oxide, N-methyl-d-aspartate (NMDA), and μ-opioid pathways. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14043DOI Listing
April 2019
4.313 Impact Factor

Indocyanine green-assisted dental imaging in the first and second near-infrared windows as compared with X-ray imaging.

Ann N Y Acad Sci 2019 Apr 5. Epub 2019 Apr 5.

Division of Electrical and Computer Engineering, College of Engineering, Louisiana State University, Baton Rouge, Louisiana.

Indocyanine green (ICG) has been widely used in medical imaging, such as in retinal angiography. Here, we describe a pilot ex vivo study of ICG-assisted near-infrared fluorescence (NIRF) dental imaging in the first (700-950 nm for ICG-NIRF-I) and second (1000-1700 nm for ICG-NIRF-II) NIR windows using human extracted teeth; our study is compared with the traditional prevalent X-ray imaging and NIR II illumination (NIRi-II, 1310 nm) without ICG enhancement. The results show that ICG fluorescence has much better imaging contrast in both windows compared with NIRi-II (by quantitatively comparing NIR intensity of the critical neighboring structures, such as enamel and dentin). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14086DOI Listing

Anti-CTLA-4 synergizes with dendritic cell-targeted vaccine to promote IL-3-dependent CD4 effector T cell infiltration into murine pancreatic tumors.

Ann N Y Acad Sci 2019 Apr 4. Epub 2019 Apr 4.

Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, New York City, New York.

One successful class of cancer immunotherapies, immune checkpoint inhibitory antibodies, disrupts key pathways that regulate immune checkpoints, such as cytotoxic T lymphocyte-associated antigen-4 (CTLA-4). These agents unleash the potency of antigen-experienced T cells that have already been induced as a consequence of the existing tumor. But only 20% of cancers naturally induce T cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14049DOI Listing
April 2019
2 Reads

Coordinating Nigeria's micronutrient deficiency control programs is necessary to prevent deficiencies and toxicity risks.

Ann N Y Acad Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Human Nutrition, Faculty of Public Health, University of Ibadan, Ibadan, Nigeria.

Nigeria has an alarming prevalence of micronutrient deficiencies that has persisted over decades. National Micronutrient Deficiency Control (MNDC) guidelines describe several interventions to address the issue. This study identified and described currently implemented interventions, assessed coverage and coordination of the interventions, and considered the risk of overdosage and gaps. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14055DOI Listing
April 2019
1 Read

Engineering of hairpin ribozyme variants for RNA recombination and splicing.

Ann N Y Acad Sci 2019 Apr 2. Epub 2019 Apr 2.

Institut für Biochemie, Universität Greifswald, Greifswald, Germany.

The hairpin ribozyme is a small, naturally occurring RNA that catalyzes the reversible cleavage of RNA substrates. Among the small endonucleolytic ribozymes, the hairpin ribozyme possesses the unique feature of the internal equilibrium between cleavage and ligation being shifted toward ligation. This allows control of the reaction outcome by structural design: fragments that are strongly bound to the ribozyme are preferentially ligated, whereas substrates that easily dissociate upon cleavage, such that they are not available for religation, are preferentially cleaved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14052DOI Listing
April 2019
2 Reads

Endothelin-A receptor in gastric cancer and enhanced antitumor activity of trastuzumab in combination with the endothelin-A receptor antagonist ZD4054.

Ann N Y Acad Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.

Endothelin-A receptor (ETAR) is overexpressed in cancers and can function through transactivation of the epidermal growth factor receptor. We explored ETAR in gastric cancer and investigated the antitumor effect of trastuzumab in combination with the ETAR antagonist ZD4054. The expression of ETAR was significantly correlated with the expression of vascular endothelial growth factor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14053DOI Listing
April 2019
1 Read

Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes.

Ann N Y Acad Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa.

Obesity is the major contributing factor for the increased prevalence of type 2 diabetes (T2D) in recent years. Sustained positive influx of lipids is considered to be a precipitating factor for beta cell dysfunction and serves as a connection between obesity and T2D. Importantly, fatty acids (FA), a key building block of lipids, are a double-edged sword for beta cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14037DOI Listing
April 2019
1 Read

A review of the major threats and challenges to global bat conservation.

Ann N Y Acad Sci 2019 Apr 2. Epub 2019 Apr 2.

Bat Conservation International, Austin, Texas.

Bats are an ecologically and taxonomically diverse group accounting for roughly a fifth of mammalian diversity worldwide. Many of the threats bats face (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14045DOI Listing

Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish.

Ann N Y Acad Sci 2019 Apr 2. Epub 2019 Apr 2.

College of Medicine, Member of QU Health, Qatar University, Doha, Qatar.

Calmodulin (CaM) is a universal calcium (Ca )-binding messenger that regulates many vital cellular events. In cardiac muscle, CaM associates with ryanodine receptor 2 (RyR2) and regulates excitation-contraction coupling. Mutations in human genes CALM1, CALM2, and CALM3 have been associated with life-threatening heart disorders, such as long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14033DOI Listing
April 2019
4 Reads
4.313 Impact Factor

Antimicrobial-resistant bacterial infections from foods of animal origin: understanding and effectively communicating to consumers.

Ann N Y Acad Sci 2019 Apr;1441(1):40-49

Independent Contractor, New York, New York.

Consumers are increasingly interested in the attributes of the food they consume. This includes what is in the food and how it was raised; and at least some consumers are willing to pay a premium for products with specific attributes. However, the current plethora of labels on the market does not adequately address this issue; rather than providing actionable information, most labels add to the consumer confusion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14091DOI Listing

From farm management to bacteriophage therapy: strategies to reduce antibiotic use in animal agriculture.

Ann N Y Acad Sci 2019 Apr;1441(1):31-39

University of Western Ontario and Agriculture and Agri-Food Canada, London, Ontario, Canada.

To reduce the use of antibiotics in animal agriculture, a number of effective or commercially viable alternatives have been implemented by food animal producers or are under development. Perhaps the most well-established strategies are flock and herd management practices to mitigate disease introduction and spread, and, subsequently, reduce the need for antibiotic use. While vaccines in food animal production have been used to prevent both bacterial and viral diseases, but historically, most vaccines have targeted viral diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14034DOI Listing

Antimicrobial resistance in a One Health context: exploring complexities, seeking solutions, and communicating risks.

Ann N Y Acad Sci 2019 Apr;1441(1):3-7

Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota.

Four articles presented in this special issue of Annals of the New York Academy of Sciences stem from a meeting of experts on antimicrobial resistance (AMR) in food animal production hosted by the New York Academy of Sciences on May 8 and 9, 2018. The articles discuss (1) competing considerations of the criticality of different classes of antimicrobials used for human and animal health and how guidelines and regulations might result in more prudent patterns of use; (2) the increasingly recognized importance of the environment (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14057DOI Listing

Critically important antibiotics: criteria and approaches for measuring and reducing their use in food animal agriculture.

Ann N Y Acad Sci 2019 Apr;1441(1):8-16

College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.

Globally, increasing acquired antimicrobial resistance among pathogenic bacteria presents an urgent challenge to human and animal health. As a result, significant efforts, such as the One Health Initiative, are underway to curtail and optimize the use of critically important antimicrobials for human medicine in all applications, including food animal production. This review discusses the rationale behind multiple and competing "critically important antimicrobial" lists and their contexts as created by international, regional, and national organizations; identifies discrepancies among these lists; and describes issues surrounding risk management recommendations that have been made by regulatory organizations on the use of antibiotics in food animal production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14058DOI Listing

Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems.

Ann N Y Acad Sci 2019 Apr;1441(1):17-30

Department of Veterinary Preventive Medicine, Ohio State University, Columbus, Ohio.

Antimicrobial resistance (AMR) is a significant threat to both human and animal health. The spread of AMR bacteria and genes across systems can occur through a myriad of pathways, both related and unrelated to agriculture, including via wastewater, soils, manure applications, direct exchange between humans and animals, and food exposure. Tracing origins and drivers of AMR bacteria and genes is challenging due to the array of contexts and the complexity of interactions overlapping health practice, microbiology, genetics, applied science and engineering, as well as social and human factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14036DOI Listing

Giant viruses: spore-like missing links between Rickettsia and mitochondria?

Authors:
Hervé Seligmann

Ann N Y Acad Sci 2019 Mar 28. Epub 2019 Mar 28.

The National Natural History Collections, the Hebrew University of Jerusalem, Jerusalem, Israel.

Phyloproteomics indicate common viral origin from ancient cells before archaea, bacteria, and eukaryota split and subsequent size and complexity reductions occurred. Further independent evidence for the cellular origin of viruses is reviewed for the virus order Megavirales, focusing on the family Poxviridae. Megavirales comprises giant viruses, double-stranded DNA viruses whose genomes exceed some bacterial ones and large enough to parasitize large-celled protists (amoeba). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14022DOI Listing
March 2019
1 Read

Unravelling the intersections between consolidation, refreshing, and removal.

Ann N Y Acad Sci 2018 Jul;1424(1):5-7

University of Geneva, Geneva, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.13943DOI Listing

No genome is an island: toward a 21st century agenda for evolution.

Authors:
James A Shapiro

Ann N Y Acad Sci 2019 Mar 22. Epub 2019 Mar 22.

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois.

Conventional 20th century evolution thinking was based on the idea of isolated genomes for each species. Any possibility of life-history inputs to the germ line was strictly excluded by Weismann's doctrine, and genome change was attributed to random copying errors. Today, we know that many life-history events lead to rapid and nonrandom evolutionary change mediated by specific cellular functions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14044DOI Listing
March 2019
1 Read

Knockdown of endothelin receptor B inhibits the progression of triple-negative breast cancer.

Ann N Y Acad Sci 2019 Mar 22. Epub 2019 Mar 22.

Department of Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China.

Endothelin receptor B (EDNRB) is one of the receptors in the endothelin axis and its upregulated expression is associated with tumorigenesis and metastasis of several types of solid tumors. However, the expression profile of EDNRB in breast cancer and its role in the progression of breast cancer are unclear. Here, we show that EDNRB expression is higher in metastatic tumors than in primary breast cancer, and is associated significantly with lymph node metastasis and poor survival in Chinese patients with breast cancer. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/nyas.14039
Publisher Site
http://dx.doi.org/10.1111/nyas.14039DOI Listing
March 2019
8 Reads

The mystery of our mathematical universe.

Ann N Y Acad Sci 2019 Mar 22. Epub 2019 Mar 22.

Institute for Figuring, Los Angeles, California.

Why is it that fundamental laws discovered through pure mathematics have been able to describe the behavior of our physical world with such precision? Given that the physical universe is composed of mathematical properties, some have posited that mathematics is the language of the universe, whose laws reveal what appears to be a hidden order in the natural world. Physicist S. James Gates, Jr. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14026DOI Listing

Excess iodine intake: sources, assessment, and effects on thyroid function.

Ann N Y Acad Sci 2019 Mar 20. Epub 2019 Mar 20.

Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland.

Iodine is essential for thyroid hormone synthesis. High iodine intakes are well tolerated by most healthy individuals, but in some people, excess iodine intakes may precipitate hyperthyroidism, hypothyroidism, goiter, and/or thyroid autoimmunity. Individuals with preexisting thyroid disease or those previously exposed to iodine deficiency may be more susceptible to thyroid disorders due to an increase in iodine intake, in some cases at intakes only slightly above physiological needs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14041DOI Listing
March 2019
1 Read

CITED2 mediates the mechanical loading-induced suppression of adipokines in the infrapatellar fat pad.

Ann N Y Acad Sci 2019 Apr 19;1442(1):153-164. Epub 2019 Mar 19.

Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York.

Adipokines secreted from the infrapatellar fat pad (IPFP), such as adipsin and adiponectin, have been implicated in osteoarthritis pathogenesis. CITED2, a mechanosensitive transcriptional regulator with chondroprotective activity, may modulate their expression. Cited2 haploinsufficient mice (Cited2 ) on a high-fat diet (HFD) exhibited increased body weight and increased IPFP area compared to wild-type (WT) mice on an HFD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14025DOI Listing
April 2019
1 Read

Sputum from chronic obstructive pulmonary disease patients inhibits T cell migration in a microfluidic device.

Ann N Y Acad Sci 2019 Mar 19. Epub 2019 Mar 19.

Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada.

Chronic obstructive pulmonary disease (COPD) is a common lung disease characterized by narrowed airways, resulting in serious breathing difficulty. Previous studies have demonstrated that inflammatory infiltration of leukocytes in the airway is associated with the pathogenesis of COPD. In the present study, we employed a microfluidic approach to assess the effect of COPD sputum on activated human peripheral blood T cell migration and chemotaxis under well-controlled gradient conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14029DOI Listing
March 2019
1 Read

CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection.

Ann N Y Acad Sci 2019 Apr 19;1442(1):128-137. Epub 2019 Mar 19.

Departments of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York.

Osteoarthritis (OA) pathogenesis is mediated largely through the actions of proteolytic enzymes such as matrix metalloproteinase (MMP) 13. The transcriptional regulator CITED2, which suppresses the expression of MMP13 in chondrocytes, is induced by interleukin (IL)-4 in T cells and macrophages, and by moderate mechanical loading in chondrocytes. We tested the hypothesis that CITED2 mediates cross-talk between IL-4 signaling and mechanical loading-induced pathways that result in chondroprotection, at least in part, by downregulating MMP13. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14021DOI Listing
April 2019
1 Read

Anemia in Bolivian children: a comparative analysis among three regions of different altitudes.

Ann N Y Acad Sci 2019 Mar 18. Epub 2019 Mar 18.

Division of Food Security and Agriculture, RTI International, Washington DC.

Here, we analyzed four population-based demographic and health surveys conducted in Bolivia between 1998 and 2016 to understand trends in anemia in children from 6 to 59 months of age by selected sociodemographic characteristics and three categories of altitude: low, medium, and high. Over the 18-year period, the prevalence of anemia was virtually unchanged while that in children living at high altitude increased. Anemia in children living at all three altitude categories is more than 40% and a severe public health problem according to the World Health Organization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14038DOI Listing
March 2019
1 Read

Recent evidence that attention is necessary, but not sufficient, for conscious perception.

Ann N Y Acad Sci 2019 Mar 18. Epub 2019 Mar 18.

Department of Psychology, and Center for Mind and Brain, University of California, Davis, California.

Early descriptions of attention in the psychological literature highlighted its interdependence with conscious awareness. As the study of attention developed, consciousness and attention began to be considered separable phenomena, experimentally and theoretically. In recent years, an energetic debate has developed concerning the extent to which the two phenomena are related. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14030DOI Listing

New York City Panel on Climate Change 2019 Report Chapter 9: Perspectives on a City in a Changing Climate 2008-2018.

Ann N Y Acad Sci 2019 Mar;1439(1):280-305

NASA Goddard Institute for Space Studies, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14017DOI Listing

New York City Panel on Climate Change 2019 Report Chapter 3: Sea Level Rise.

Ann N Y Acad Sci 2019 Mar;1439(1):71-94

Center for Climate Systems Research, Columbia University, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14006DOI Listing

New York City Panel on Climate Change 2019 Report Chapter 8: Indicators and Monitoring.

Ann N Y Acad Sci 2019 Mar;1439(1):230-279

NASA Goddard Institute for Space Studies, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14014DOI Listing

New York City Panel on Climate Change 2019 Report: Conclusions and Recommendations.

Authors:

Ann N Y Acad Sci 2019 Mar;1439(1):306-311

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14032DOI Listing

Foreword.

Authors:
Bill de Blasio

Ann N Y Acad Sci 2019 Mar;1439(1):10

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14061DOI Listing

Disclaimers.

Authors:

Ann N Y Acad Sci 2019 Mar;1439(1)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14048DOI Listing

New York City Panel on Climate Change 2019 Report Executive Summary.

Authors:

Ann N Y Acad Sci 2019 Mar;1439(1):11-21

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14008DOI Listing

New York City Panel on Climate Change 2019 Report Chapter 5: Mapping Climate Risk.

Ann N Y Acad Sci 2019 Mar;1439(1):115-125

Jupiter Intelligence, San Mateo, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14015DOI Listing

New York City Panel on Climate Change 2019 Report Chapter 1: Introduction.

Ann N Y Acad Sci 2019 Mar;1439(1):22-29

City University of New York, Hunter College, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14004DOI Listing

New York City Panel on Climate Change 2019 Report Chapter 4: Coastal Flooding.

Ann N Y Acad Sci 2019 Mar;1439(1):95-114

City University of New York, Hunter College, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14011DOI Listing

Learning resources and talent development from a systemic point of view.

Ann N Y Acad Sci 2019 Mar 15. Epub 2019 Mar 15.

Department of Educational Sciences, University of Regensburg, Regensburg, Germany.

System theories postulate that a system needs resources in order to evolve and function as an entirety. According to the actiotope model of giftedness, exogenous and endogenous resources needed to develop excellence include five forms of educational capital (economic, cultural, social, infrastructural, and didactic) and five forms of learning capital (organismic, telic, actional, episodic, and attentional), independent of domain and level of talent development. In three studies, we addressed several blind spots in the empirical basis of the educational and learning capital (ELC) approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14018DOI Listing
March 2019
1 Read

Neural mechanisms of social homeostasis.

Ann N Y Acad Sci 2019 Mar 15. Epub 2019 Mar 15.

Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Social connections are vital to survival throughout the animal kingdom and are dynamic across the life span. There are debilitating consequences of social isolation and loneliness, and social support is increasingly a primary consideration in health care, disease prevention, and recovery. Considering social connection as an "innate need," it is hypothesized that evolutionarily conserved neural systems underlie the maintenance of social connections: alerting the individual to their absence and coordinating effector mechanisms to restore social contact. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/nyas.14016
Publisher Site
http://dx.doi.org/10.1111/nyas.14016DOI Listing
March 2019
12 Reads

Human pluripotent stem cell-derived models and drug screening in CNS precision medicine.

Ann N Y Acad Sci 2019 Mar 15. Epub 2019 Mar 15.

Chemical Neurobiology Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts.

Development of effective therapeutics for neurological disorders has historically been challenging partly because of lack of accurate model systems in which to investigate disease etiology and test new therapeutics at the preclinical stage. Human stem cells, particularly patient-derived induced pluripotent stem cells (iPSCs) upon differentiation, have the ability to recapitulate aspects of disease pathophysiology and are increasingly recognized as robust scalable systems for drug discovery. We review advances in deriving cellular models of human central nervous system (CNS) disorders using iPSCs along with strategies for investigating disease-relevant phenotypes, translatable biomarkers, and therapeutic targets. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14012DOI Listing
March 2019
1 Read

A model of different cognitive processes during spontaneous and intentional coupling to music in multiple sclerosis.

Ann N Y Acad Sci 2019 Mar 13. Epub 2019 Mar 13.

IPEM Institute of Psychoacoustics and Electronic Music, Faculty of Arts and Philosophy, Ghent University, Ghent, Belgium.

Evidence for using auditory-motor coupling in neurological rehabilitation to facilitate walking is increasing. However, the distinction between spontaneous and intended coupling and its underlying mechanisms is yet to be investigated. In this study, we include 30 persons with multiple sclerosis and 30 healthy controls (HCs) in an experiment with two sessions in which participants were asked to walk to music with various tempi, matching their preferred walking cadence (PWC) up to 10% above in incremental steps of 2%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14023DOI Listing
March 2019
1 Read

That is life: communicating RNA networks from viruses and cells in continuous interaction.

Ann N Y Acad Sci 2019 Mar 13. Epub 2019 Mar 13.

Telos-Philosophische Praxis, Buermoos, Austria.

All the conserved detailed results of evolution stored in DNA must be read, transcribed, and translated via an RNA-mediated process. This is required for the development and growth of each individual cell. Thus, all known living organisms fundamentally depend on these RNA-mediated processes. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/nyas.14040
Publisher Site
http://dx.doi.org/10.1111/nyas.14040DOI Listing
March 2019
2 Reads

The codon usage pattern of genes involved in ovarian cancer.

Ann N Y Acad Sci 2019 Mar 6;1440(1):67-78. Epub 2019 Mar 6.

Department of Biotechnology, Assam University, Assam, India.

In this study, we analyzed the compositional dynamics and codon usage pattern of genes involved in ovarian cancer (OC) using a computational method. Mutations in specific genes are associated with OC, and some genes are risk factors for progression of OC, but no work has been reported yet on the codon usage pattern of genes involved in OC. Nucleotide composition analysis of OC-related genes suggested that the overall GC content was higher than AT content; that is, the genes were GC rich. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14019DOI Listing