49,252 results match your criteria Ann. N. Y. Acad. Sci.[Journal]


DNA methylation in the pathology of Alzheimer's disease: from gene to cognition.

Ann N Y Acad Sci 2020 Jun 3. Epub 2020 Jun 3.

Neuromodulation Laboratory, Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, the University of Hong Kong, Hong Kong, P. R. China.

Alzheimer's disease (AD) is a debilitating disorder that manifests with amyloid beta plaque deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although much effort has been made to decipher the pathogenesis of this disease, the mechanisms causing these detrimental outcomes remain obscure. Over the past few decades, neuroepigenetics has emerged as an important field that, among other things, explores how reversible modifications can change gene expression to control behavior and cognitive abilities. Read More

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http://dx.doi.org/10.1111/nyas.14373DOI Listing

A highly selective and sensitive fluorescence probe for a specific binding site on insect ryanodine receptors.

Ann N Y Acad Sci 2020 Jun 1. Epub 2020 Jun 1.

Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, China.

There is a significant need to study the binding of active compounds to the specific sites on insect ryanodine receptors (RyRs) that are the targets of two novel classes of diamide insecticides to which insects are becoming increasingly resistant. Here, we describe a rapid assay to study the action of potential compounds on the flubendiamide (Flu) binding site of insect RyRs that uses a fluorescence polarization assay with the fluorescence probe Flu-R-L that we synthesized. The IC of Flu for inhibiting probe binding on insect RyR was 18. Read More

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http://dx.doi.org/10.1111/nyas.14362DOI Listing

LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.

Ann N Y Acad Sci 2020 Jun 1. Epub 2020 Jun 1.

Department of Geriatrics, The Second Xiangya Hospital, Institute of Aging and Age-Related Disease Research, Central South University, Changsha, Hunan, People's Republic of China.

Long noncoding RNAs (lncRNAs) have been investigated as novel regulatory molecules involved in diverse biological processes. Our previous study demonstrated that lncRNA-ES3 is associated with the high glucose-induced calcification/senescence of human aortic vascular smooth muscle cells (HA-VSMCs). However, the mechanism of lncRNA-ES3 in vascular calcification/aging remained largely unknown. Read More

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http://dx.doi.org/10.1111/nyas.14381DOI Listing

Alternatives to amyloid for Alzheimer's disease therapies-a symposium report.

Ann N Y Acad Sci 2020 May 29. Epub 2020 May 29.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

For decades, Alzheimer's disease research has focused on amyloid as the primary pathogenic agent. This focus has driven the development of numerous amyloid-targeting therapies; however, with one possible exception, none of these therapies have been effective in preventing or delaying cognitive decline in patients, and there are no approved disease-modifying agents. It is becoming more apparent that alternative drug targets are needed to address this complex disease. Read More

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http://dx.doi.org/10.1111/nyas.14371DOI Listing

Short-term caloric restriction induced bone loss in both axial and appendicular bones by increasing adiponectin.

Ann N Y Acad Sci 2020 May 29. Epub 2020 May 29.

Department of Orthopedics, Peking University Third Hospital, Beijing, China.

Caloric restriction (CR) is well described and has received extensive attention for its multiple benefits, including longevity and stress resistance. However, some studies have shown that CR negatively influences bone, although a mechanism hasn't been provided. Adiponectin, an adipocyte-derived hormone, can affect bone metabolism by various pathways. Read More

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http://dx.doi.org/10.1111/nyas.14380DOI Listing

Relationships between objective sleep parameters and inflammatory biomarkers in pregnancy.

Ann N Y Acad Sci 2020 May 28. Epub 2020 May 28.

College of Nursing, University of Illinois at Chicago, Chicago, Illinois.

We examined the relationships between sleep and inflammatory biomarkers during late pregnancy. Seventy-four women underwent an overnight sleep assessment by polysomnography. Blood samples were collected before bedtime and again within 1 h upon awakening to measure C-reactive protein (CRP), interleukin (IL)-6, and IL-6 soluble receptor. Read More

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http://dx.doi.org/10.1111/nyas.14375DOI Listing

Glial evolution as a determinant of human behavior and its disorders.

Authors:
Steven A Goldman

Ann N Y Acad Sci 2020 May 25. Epub 2020 May 25.

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York.

Astroglial complexity and pleomorphism have increased significantly with hominid evolution. This suggests a potential association between glial evolution and the development of human cognition, as well as between glial evolution and the advent of human-selective neurodegenerative and neuropsychiatric disorders. Read More

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http://dx.doi.org/10.1111/nyas.14372DOI Listing

A multimodel evaluation of the water vapor budget in atmospheric rivers.

Ann N Y Acad Sci 2020 May 22. Epub 2020 May 22.

Center for Western Weather and Water Extremes, Scripps Institution of Oceanography, University of California, San Diego, California.

Atmospheric rivers (ARs) are narrow regions of strong horizontal water vapor transport that play important roles in the global water cycle, weather, and hydrology. Motivated by challenges in simulating ARs with state-of-the-art global models, this paper diagnoses model errors with a focus on relative contributions of moisture convergence, evaporation, and precipitation to AR column-integrated water vapor (IWV) budget. Using 20-year simulations by 24 global weather/climate models, budget terms are calculated for four AR sectors: postfrontal, frontal, prefrontal, and pre-AR, with biases assessed against two reanalysis products. Read More

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http://dx.doi.org/10.1111/nyas.14368DOI Listing

Macrophage targeting in cancer.

Ann N Y Acad Sci 2020 May 22. Epub 2020 May 22.

MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.

Tumorigenesis is not only determined by the intrinsic properties of cancer cells but also by their interactions with components of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are among the most abundant immune cells in the TME. During initial stages of tumor development, macrophages can either directly promote antitumor responses by killing tumor cells or indirectly recruit and activate other immune cells. Read More

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http://dx.doi.org/10.1111/nyas.14377DOI Listing

Changes in South American hydroclimate under projected Amazonian deforestation.

Ann N Y Acad Sci 2020 May 22. Epub 2020 May 22.

Non-Linear Physics Group, Universidade de Santiago de Compostela, Galicia, Spain.

Continued deforestation in the Amazon forest can alter the subsurface/surface and atmospheric branches of the hydrologic cycle. The sign and magnitude of these changes depend on the complex interactions between the water, energy, and momentum budgets. To understand these changes, we use the weather research and forecasting (WRF) model with improved representation of groundwater dynamics and the added feature of Amazonian moisture tracers. Read More

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http://dx.doi.org/10.1111/nyas.14364DOI Listing

Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[ F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [ F]-VXS.

Ann N Y Acad Sci 2020 May 20. Epub 2020 May 20.

Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana.

Oxime antidotes regenerate organophosphate-inhibited acetylcholinesterase (AChE). Although they share a common mechanism of AChE reactivation, the rate and amount of oxime that enters the brain are critical to the efficacy, a process linked to the oxime structure and charge. Using a platform based on the organophosphate [ F]-VXS as a positron emission tomography tracer for active AChE, the in vivo distribution of [ F]-VXS was evaluated after an LD dose (250 μg/kg) of the organophosphate paraoxon (POX) and following oximes as antidotes. Read More

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http://dx.doi.org/10.1111/nyas.14363DOI Listing

Diagnosis of gastroesophageal reflux: an update on current and emerging modalities.

Ann N Y Acad Sci 2020 May 19. Epub 2020 May 19.

Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri.

Gastroesophageal reflux disease (GERD) is a common condition characterized by troublesome symptoms or esophageal mucosal lesions attributed to excessive esophageal acid exposure. Various pathophysiological mechanisms account for GERD, including impaired esophageal peristalsis and anatomical or physiological defects at the esophagogastric junction (EGJ). Endoscopy identifies GERD complications and detects potential alternative diagnoses. Read More

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http://dx.doi.org/10.1111/nyas.14369DOI Listing

Tissue stiffness contributes to YAP activation in bladder cancer patients undergoing transurethral resection.

Ann N Y Acad Sci 2020 May 19. Epub 2020 May 19.

Urology & Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Changes in the cellular microenvironment play a critical role in the development of bladder cancer (BC). Yes-associated protein (YAP), a central mediator of the Hippo pathway, functions as a nuclear sensor of mechanotransduction that can be induced by stiffness of the extracellular matrix (ECM), including stiffness resulting from surgical manipulations. We aimed to clarify the possible association between surgically-related ECM stiffness and YAP activation in BC patients. Read More

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http://dx.doi.org/10.1111/nyas.14358DOI Listing

Acute cytotoxicity and increased vascular endothelial growth factor after in vitro nitrogen mustard vapor exposure.

Ann N Y Acad Sci 2020 May 14. Epub 2020 May 14.

Department of Pediatrics, Pulmonology Section, Pediatric Airway Research Center, University of Colorado Denver, Aurora, Colorado.

Nitrogen mustard (NM) is a highly toxic alkylating agent. Inhalation exposure can cause acute and chronic lung injury. This study's aims were to develop an in vitro coculture model of mustard-induced airway injury and to identify growth factors contributing to airway pathology. Read More

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http://dx.doi.org/10.1111/nyas.14367DOI Listing

Biodiversity conservation through the lens of metacommunity ecology.

Ann N Y Acad Sci 2020 May 14. Epub 2020 May 14.

German Centre for Integrative Biodiversity Research (iDiv), Halle-Jena-Leipzig, Germany.

Metacommunity ecology combines local (e.g., environmental filtering and biotic interactions) and regional (e. Read More

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http://dx.doi.org/10.1111/nyas.14378DOI Listing

Characteristics and trends of flash droughts in Spain, 1961-2018.

Ann N Y Acad Sci 2020 May 14. Epub 2020 May 14.

Instituto Pirenaico de Ecología, Consejo Superior de Investigaciones Científicas (IPE-CSIC), Zaragoza, Spain.

Flash droughts are characterized by rapid onset and intensification, as well as major environmental and agricultural impacts. In this study, we developed an objective method for identifying flash droughts using the standardized evaporation precipitation index (SPEI) based on a short time scale (1-month) and high-frequency data (weekly). The identification of flash droughts was focused on the development phase, anomalous decreases in index values in a short time period (4 weeks), and the magnitude of the events. Read More

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http://dx.doi.org/10.1111/nyas.14365DOI Listing

Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations.

Ann N Y Acad Sci 2020 May 13. Epub 2020 May 13.

Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.

Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric upper and lower airway diseases. However, the diagnosis of proximal reflux-associated disease remains challenging due to evolving clinical criteria and institutional and regional variances in diagnostic practices. Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators of and biomarkers for reflux in the upper airway. Read More

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http://dx.doi.org/10.1111/nyas.14366DOI Listing

Designer drugs: a medicinal chemistry perspective (II).

Ann N Y Acad Sci 2020 May 12. Epub 2020 May 12.

Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina.

During 2012-2018, the clandestine manufacture of new psychoactive substances (NPS) designed to circumvent substance control regulations increased exponentially worldwide, with concomitant increase in fatalities. This review focuses on three compound classes identified as synthetic opioids, synthetic amphetamines, and synthetic cannabinoids and highlights the medicinal chemistry precedents utilized by clandestine laboratories to develop new NPS with increased brain penetration, longer duration of action, and greater potency. Chemical approaches to illicit drug abuse treatment options, particularly for opioid use disorder, are also discussed. Read More

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http://dx.doi.org/10.1111/nyas.14349DOI Listing
May 2020
4.313 Impact Factor

The SARS-CoV-2/COVID-19 pandemic and challenges in stroke care in India.

Ann N Y Acad Sci 2020 May 12. Epub 2020 May 12.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India.

Stroke care in India has evolved rapidly in the last decade with a focus on stroke awareness, prevention, rapid triage, treatment, and rehabilitation. But acute stroke care and poststroke rehabilitation in the country have limitations owing to the economic constraints and poor access to health care. The SARS-CoV-2/COVID-19 pandemic has made stroke care even more challenging. Read More

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http://dx.doi.org/10.1111/nyas.14379DOI Listing

Exploring food security and nutrition among young women in the formally regulated garment sector of Myanmar.

Ann N Y Acad Sci 2020 May 12;1468(1):35-54. Epub 2020 May 12.

School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom.

Malnutrition can adversely influence women's overall health and development and that of their children. In the Yangon region of Myanmar, young women aged 15-19 years can be excessively thin, overweight, or anemic. A significant proportion of these young women working within the formal sector are employed in the garment industry. Read More

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http://dx.doi.org/10.1111/nyas.14370DOI Listing

Projected changes in flooding: a continental U.S. perspective.

Ann N Y Acad Sci 2020 May 9. Epub 2020 May 9.

IIHR-Hydroscience & Engineering, The University of Iowa, Iowa City, Iowa.

Our study focuses on the projected changes in annual and seasonal maximum daily runoff (used as a proxy for flooding) across the continental United States based on outputs from eight global climate models (GCMs) from the Sixth Coupled Model Intercomparison Project (CMIP6). Analyses performed at the regional scale indicate that the GCMs are generally able to reproduce the observed changes in runoff extremes, especially at the seasonal scale, with no single model that outperforms the others across the different seasons and regions. Overall, annual maximum daily runoff is projected to increase during the 21st century, especially in large areas of the southeastern United States and Pacific Northwest, and to decrease in the Rocky Mountains and the northern Great Plains. Read More

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http://dx.doi.org/10.1111/nyas.14359DOI Listing
May 2020
4.313 Impact Factor

Intensification of the global water cycle and evidence from ocean salinity: a synthesis review.

Ann N Y Acad Sci 2020 May 9. Epub 2020 May 9.

Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California.

The ocean plays a dominant role in the global water cycle. It is the center of action for global evaporation and precipitation and supplies the moisture that falls as continental precipitation. It also acts to some extent as nature's rain gauge, as it tells us about the long-term changes in the global water cycle through monitoring of the changes in ocean surface salinity. Read More

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http://dx.doi.org/10.1111/nyas.14354DOI Listing

Atmospheric heat and moisture transport to energy- and water-limited ecosystems.

Ann N Y Acad Sci 2020 May 7. Epub 2020 May 7.

Hydro-Climate Extremes Lab, Ghent University, Ghent, Belgium.

The land biosphere is a crucial component of the Earth system that interacts with the atmosphere in a complex manner through manifold feedback processes. These relationships are bidirectional, as climate affects our terrestrial ecosystems, which, in turn, influence climate. Great progress has been made in understanding the local interactions between the terrestrial biosphere and climate, but influences from remote regions through energy and water influxes to downwind ecosystems remain less explored. Read More

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http://dx.doi.org/10.1111/nyas.14357DOI Listing

Antidotal effects of methylene blue against cyanide neurological toxicity: in vivo and in vitro studies.

Ann N Y Acad Sci 2020 May 6. Epub 2020 May 6.

Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania.

The aim of the present study was to determine whether methylene blue (MB) could directly oppose the neurological toxicity of a lethal cyanide (CN) intoxication. KCN, infused at the rate of 0.375 mg/kg/min intravenously, produced 100% lethality within 15 min in unanaesthetized rats (n = 12). Read More

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http://dx.doi.org/10.1111/nyas.14353DOI Listing

Is the prevalence of anemia in children living at high altitudes real? An observational study in Peru.

Ann N Y Acad Sci 2020 May 6. Epub 2020 May 6.

Laboratorio de Endocrinología y Reproducción, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.

Anemia diagnosis in populations residing at high altitude (HA) involves an adjustment of hemoglobin (Hb) values owing to the increase in its concentration with altitude. The suitability of the adjustment has been questioned since Hb concentrations depend on how adapted a population is to HA. In Peru, anemia in preschool children (PSC) is a matter of severe public concern for its high rates; in the city of Puno (∼3800 MASL), for example, 67. Read More

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http://dx.doi.org/10.1111/nyas.14356DOI Listing

Gait training for adults with cerebral palsy following harmonic modification in rhythmic auditory stimulation.

Ann N Y Acad Sci 2020 Apr 30. Epub 2020 Apr 30.

Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea.

This study aimed to investigate the differences in gait outcomes of young adults with cerebral palsy (CP) following rhythmic auditory stimulation (RAS) with different types of cueing. A total of 13 ambulatory adults with CP were recruited. The participants were assigned to receive either RAS with simple chords or RAS with complex chords. Read More

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http://dx.doi.org/10.1111/nyas.14306DOI Listing

The spatial-numerical association of response codes effect and math skills: why related?

Ann N Y Acad Sci 2020 Apr 29. Epub 2020 Apr 29.

Faculty of Science, Department of Psychology, University of Tübingen, Tübingen, Germany.

Evidence from multiple studies conducted in the past few decades converges on the conclusion that numerical properties can be associated with specific directions in space. Such spatial-numerical associations (SNAs), as a signature of elementary number processing, seem to be a likely correlate of math skills. Nevertheless, almost three decades of research on the spatial-numerical association of response codes (SNARC) effect, the hallmark of SNAs, has not provided conclusive results on whether there is a relation with math skills. Read More

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http://dx.doi.org/10.1111/nyas.14355DOI Listing

Cutaneous lewisite exposure causes acute lung injury.

Ann N Y Acad Sci 2020 Apr 24. Epub 2020 Apr 24.

Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Lewisite is a strong vesicating and chemical warfare agent. Because of the rapid transdermal absorption, cutaneous exposure to lewisite can also elicit severe systemic injury. Lewisite (2. Read More

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http://dx.doi.org/10.1111/nyas.14346DOI Listing

Central neuroprotection demonstrated by novel oxime countermeasures to nerve agent surrogates.

Ann N Y Acad Sci 2020 Apr 21. Epub 2020 Apr 21.

Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi.

Oximes remain a long-standing element of the therapy for nerve agents, organophosphates (OPs) that poison by inhibiting the enzyme acetylcholinesterase (AChE), resulting in hypercholinergic activity both centrally and peripherally. Oximes, such as the pyridinium oxime pralidoxime (2-PAM) in the United States, can reactivate the inhibited AChE and restore cholinergic function. However, there are several drawbacks to the current oximes; one of them, the inability of these oximes to effectively enter the brain, is the subject of study by several laboratories, including ours. Read More

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http://dx.doi.org/10.1111/nyas.14352DOI Listing

About the interplay between internal and external spatial codes in the mind: implications for serial order.

Ann N Y Acad Sci 2020 Apr 20. Epub 2020 Apr 20.

Department of Experimental Psychology, Ghent University, Ghent, Belgium.

Previous studies have shown that serial order in verbal working memory is spontaneously coded along the horizontal axis (i.e., the spatial positional association response codes (SPoARC) effect), with the initial items being associated with left and the last items being associated with right. Read More

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http://dx.doi.org/10.1111/nyas.14341DOI Listing

Methylene blue and monosodium glutamate improve neurologic signs after fluoroacetate poisoning.

Ann N Y Acad Sci 2020 Apr 14. Epub 2020 Apr 14.

Pharmaceutical Sciences Department, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.

Fluoroacetate (FA) is a tasteless, odorless, water-soluble metabolic poison with severe toxicological effects. Characterized in the mid-1900s, it has been used as a rodenticide but is comparably lethal to all mammals. Many countries have restricted its use, and modern-day accidental human exposures are rare, but recently, concerns have been raised about its application as a chemical weapon with no known antidote. Read More

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http://dx.doi.org/10.1111/nyas.14347DOI Listing
April 2020
4.313 Impact Factor

Clinical course of gastroesophageal reflux disease and impact of treatment in symptomatic young patients.

Ann N Y Acad Sci 2020 Apr 8. Epub 2020 Apr 8.

Department of Surgery, University of Washington School of Medicine and VA Puget Sound Health Care System, Seattle, Washington.

In symptomatic young patients with gastroesophageal reflux symptoms, early identification of progressive gastroesophageal reflux disease (GERD) is critical to prevent long-term complications associated with hiatal hernia, increased esophageal acid and nonacid exposure, release of proinflammatory cytokines, and development of intestinal metaplasia, endoscopically visible Barrett's esophagus, and dysplasia leading to esophageal adenocarcinoma. Progression of GERD may occur in asymptomatic patients and in those under continuous acid-suppressive medication. The long-term side effects of proton-pump inhibitors, chemopreventive agents, and radiofrequency ablation are contentious. Read More

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http://dx.doi.org/10.1111/nyas.14350DOI Listing

Hemispheric specialization in spatial versus ordinal processing in the day-old domestic chick (Gallus gallus).

Ann N Y Acad Sci 2020 Apr 8. Epub 2020 Apr 8.

Department of General Psychology, University of Padova, Padova, Italy.

Different species show an intriguing similarity in representing numerosity in space, starting from left to right. This bias has been attributed to a right hemisphere dominance in processing spatial information. Here, to disentangle the role of each hemisphere in dealing with spatial versus ordinal-numerical information, we tested domestic chicks during monocular versus binocular vision. Read More

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http://dx.doi.org/10.1111/nyas.14345DOI Listing

Advances in understanding large-scale responses of the water cycle to climate change.

Ann N Y Acad Sci 2020 Apr 4. Epub 2020 Apr 4.

L'Institut des Géosciences de l'Environnement/Centre National de la Recherche Scientifique, L'Université Grenoble Alpes, Grenoble, France.

Globally, thermodynamics explains an increase in atmospheric water vapor with warming of around 7%/°C near to the surface. In contrast, global precipitation and evaporation are constrained by the Earth's energy balance to increase at ∼2-3%/°C. However, this rate of increase is suppressed by rapid atmospheric adjustments in response to greenhouse gases and absorbing aerosols that directly alter the atmospheric energy budget. Read More

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http://dx.doi.org/10.1111/nyas.14337DOI Listing

Predictors of close faculty-student relationships and mentorship in higher education: findings from the Gallup-Purdue Index.

Ann N Y Acad Sci 2020 Apr 3. Epub 2020 Apr 3.

Department of Psychology, University of Massachusetts, Boston, Massachusetts.

College students' supportive relationships with mentors-professors, advisors, and other caring adults to whom students turn as they develop their interests and career paths-are critical to their development and academic success. The current study sought to explore factors that promote or impede the formation of positive mentor-student relationships during college using a large, nationally representative sample of 5,684 college graduates from the Gallup-Purdue Index. Linear regression models revealed that first-generation college students, as well as students attending larger institutions, rated faculty and other college staff as less caring and supportive, and were less able to identify a supportive mentoring relationship during college. Read More

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http://dx.doi.org/10.1111/nyas.14342DOI Listing

Unique bone marrow blood vessels couple angiogenesis and osteogenesis in bone homeostasis and diseases.

Ann N Y Acad Sci 2020 Apr 3. Epub 2020 Apr 3.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Blood vessels serve as a versatile transport system and play crucial roles in organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular stem cells or osteoprogenitor cells and thereby regulate bone formation. Recent studies reported that a specialized capillary subtype, termed type H vessels, is shown to couple angiogenesis and osteogenesis in rodents and humans. Read More

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http://dx.doi.org/10.1111/nyas.14348DOI Listing

A sex-balanced rodent model for evaluating phosphine inhalation toxicity.

Ann N Y Acad Sci 2020 Apr 3. Epub 2020 Apr 3.

Pharmaceutical Sciences Department, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.

Exposure to phosphine (PH ), a common grain fumigant, is characterized by diverse nonspecific symptoms and a high mortality rate. Although PH poisoning is thought to target oxidative respiration, the exact mechanism of action remains largely unknown, resulting in limited treatment options. In our study, the effects of PH on female rats were assessed to elucidate potential sex-specific differences and obtain a more comprehensive understanding of PH toxicity. Read More

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http://dx.doi.org/10.1111/nyas.14343DOI Listing

Electroencephalographic analysis in soman-exposed 21-day-old rats and the effects of midazolam or LY293558 with caramiphen.

Ann N Y Acad Sci 2020 Mar 31. Epub 2020 Mar 31.

Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

Acute nerve agent exposure induces status epilepticus (SE), which can cause brain damage or death. Research aiming at developing effective therapies for controlling nerve agent-induced SE is commonly performed in adult rats. The characteristics of nerve agent-induced SE in young rats are less clear; relevant knowledge is necessary for developing effective pediatric therapies. Read More

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http://dx.doi.org/10.1111/nyas.14331DOI Listing

Intramuscular aminotetrazole cobinamide as a treatment for inhaled hydrogen sulfide poisoning in a large swine model.

Ann N Y Acad Sci 2020 Mar 31. Epub 2020 Mar 31.

Department of Emergency Medicine, School of Medicine, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado.

Hydrogen sulfide (H S), a high-threat chemical agent, occurs naturally in a variety of settings. Despite multiple incidents of exposures and deaths, no FDA-approved antidote exists. A rapid-acting, easy to administer antidote is needed. Read More

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http://dx.doi.org/10.1111/nyas.14339DOI Listing

Alleviation of methyl isocyanate-induced airway obstruction and mortality by tissue plasminogen activator.

Ann N Y Acad Sci 2020 Mar 31. Epub 2020 Mar 31.

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Methyl isocyanate (MIC, "Bhopal agent") is a highly reactive, toxic industrial chemical. Inhalation of high levels (500-1000 ppm) of MIC vapor is almost uniformly fatal. No therapeutic interventions other than supportive care have been described that can delay the onset of illness or death due to MIC. Read More

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http://dx.doi.org/10.1111/nyas.14344DOI Listing

Pilot randomized trial of brief school-based mentoring for middle school students with elevated disruptive behavior.

Ann N Y Acad Sci 2020 Mar 31. Epub 2020 Mar 31.

The Curry School of Education, University of Virginia, Charlottesville, Virginia.

We report a pilot study of a brief (i.e., 10 sessions) goal-focused mentoring program for middle school students with elevated disruptive behavior. Read More

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http://dx.doi.org/10.1111/nyas.14334DOI Listing

Hydrological cycle changes under global warming and their effects on multiscale climate variability.

Ann N Y Acad Sci 2020 Mar 28. Epub 2020 Mar 28.

College of Marine Sciences, Shanghai Ocean University, Pudong, Shanghai, China.

Despite a globally uniform increase in the concentrations of emitted greenhouse gases, radiatively forced surface warming can have significant spatial variations. These define warming patterns that depend on preexisting climate states and through atmospheric and oceanic dynamics can drive changes of the hydrological cycle with global-scale feedbacks. Our study reviews research progress on the hydrological cycle changes and their effects on multiscale climate variability. Read More

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http://dx.doi.org/10.1111/nyas.14335DOI Listing

Citizen science in ecology: a place for humans in nature.

Ann N Y Acad Sci 2020 Mar 26. Epub 2020 Mar 26.

School of Biological Sciences, University of Utah, Salt Lake City, Utah.

By involving the public, citizen science runs against the grain of an idealized science that leaves out the human element, and thus provides new opportunities for ecological research and society. We classify the goals of citizen science in ecology and environment into four broad categories: (1) scientific, (2) participant benefits, (3) community, and (4) policy. Although none of these goals have been well studied, we review the literature showing that these projects are most effective in tracking ecological trends over large swaths of space and time, and discuss the challenges of recruiting, training, retaining, and educating participants, maintaining and disseminating high-quality data, and connecting with the larger community and policy. Read More

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http://dx.doi.org/10.1111/nyas.14340DOI Listing

Bisphosphonates and atrial fibrillation: revisiting the controversy.

Ann N Y Acad Sci 2020 Mar 24. Epub 2020 Mar 24.

Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.

Bisphosphonates (BPs) are widely prescribed drugs used to treat osteoporosis, commonly arising in postmenopausal women and in chronic glucocorticoid use. Their mechanism of action is through inhibiting osteoclast-induced bone remodeling, and they also possess calcium sequestering properties. Common side effects involve the gastrointestinal system and rare but serious side effects, including osteonecrosis of the jaw. Read More

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http://dx.doi.org/10.1111/nyas.14332DOI Listing

Grading animal distress and side effects of therapies.

Ann N Y Acad Sci 2020 Mar 24. Epub 2020 Mar 24.

Rudolf-Zenker Institute of Experimental Surgery, University Medical Center, Rostock, Germany.

In order to combine high-quality research with minimal harm to animals, a prospective severity assessment for animal experiments is legally required in many countries. In addition, an assessment of the evidence-based severity level might allow realistic harm-benefit analysis and the appraisal of refinement methods. However, only a few examples describe the distress of animals by simple, cost-efficient, and noninvasive methods. Read More

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http://dx.doi.org/10.1111/nyas.14338DOI Listing

Myeloid cells in sepsis-acquired immunodeficiency.

Ann N Y Acad Sci 2020 Mar 23. Epub 2020 Mar 23.

EA 7426 Pathophysiology of Injury-Induced Immunosuppression (PI3), Claude Bernard University Lyon 1, Hospices Civils de Lyon, Lyon, France.

On May 2017, the World Health Organization recognized sepsis as a global health priority. Sepsis profoundly perturbs immune homeostasis by initiating a complex response that varies over time, with the concomitant occurrence of pro- and anti-inflammatory mechanisms. Sepsis deeply impacts myeloid cell response. Read More

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http://dx.doi.org/10.1111/nyas.14333DOI Listing

Diagnostics and treatment of nerve agent poisoning-current status and future developments.

Ann N Y Acad Sci 2020 Mar 21. Epub 2020 Mar 21.

Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.

Although 193 states have committed to the Chemical Weapons Convention and 98% of the declared chemical weapons stockpiles have been destroyed so far, nerve agent poisoning remains a lingering threat. The recent dissemination of sarin in Syria, the assassination of Kim Jong-Nam in Malaysia, and the assault on Sergei Skripal in the United Kingdom underline the need for effective treatment. The current therapeutic options of a muscarinic receptor antagonist, an oxime, and an anticonvulsant have been unchanged for decades. Read More

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http://dx.doi.org/10.1111/nyas.14336DOI Listing
March 2020
4.313 Impact Factor

An investigation of self-efficacy crossover between mentors and protégés within mentoring dyads.

Ann N Y Acad Sci 2020 Mar 17. Epub 2020 Mar 17.

Department of Psychology, Northern Illinois University, DeKalb, Illinois.

Our current research investigated how mentors enhance protégé self-efficacy. Drawing from social comparison theory, we propose that the shared experience between mentors and protégés facilitates the ability of protégés to adopt the perspective of their mentors. Additionally, the perspective-taking that a protégé engages in enables them to ascribe positive aspects of their mentor (i. Read More

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http://dx.doi.org/10.1111/nyas.14324DOI Listing

Antibodies against human papillomavirus proteins in Barrett's dysplasia and intramucosal esophageal adenocarcinoma.

Ann N Y Acad Sci 2020 Mar 13. Epub 2020 Mar 13.

Gastro-Intestinal Viral Oncology Group, Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia.

High-risk human papillomavirus (HPV) types 16/18 have been associated with Barrett's dysplasia (BD)/esophageal adenocarcinoma (EAC). Nevertheless, no data exist in relation to serological analysis for HPV antibodies in BD/EAC with site-specific viral DNA status. We prospectively examined antibodies to multiple HPV types in 438 patients representing hospital/reflux controls and Barrett's metaplasia (BM)/BD/intramucosal EAC. Read More

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http://dx.doi.org/10.1111/nyas.14328DOI Listing

Community context for mechanisms of disease dilution: insights from linking epidemiology and plant-soil feedback theory.

Ann N Y Acad Sci 2020 Mar 13. Epub 2020 Mar 13.

Department of Biology, Sarah Lawrence College, Bronxville, New York.

In many natural systems, diverse host communities can reduce disease risk, though less is known about the mechanisms driving this "dilution effect." We relate feedback theory, which focuses on pathogen-mediated coexistence, to mechanisms of dilution derived from epidemiological models, with the central goal of gaining insights into host-pathogen interactions in a community context. We first compare the origin, structure, and application of epidemiological and feedback models. Read More

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http://dx.doi.org/10.1111/nyas.14325DOI Listing