1,783 results match your criteria Ann Diagn Pathol[Journal]


Editorial: On continuing to educate during these times.

Ann Diagn Pathol 2020 Jun 27;47:151555. Epub 2020 Jun 27.

Cleveland Clinic Lerner College of Medicine, Department of Anatomic Pathology, Cleveland Clinic, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320264PMC

Pathologists should probably forget about kappa. Percent agreement, diagnostic specificity and related metrics provide more clinically applicable measures of interobserver variability.

Ann Diagn Pathol 2020 Jun 28;47:151561. Epub 2020 Jun 28.

Department of Pathology, UMC, Vrije Universiteit Amsterdam, the Netherlands.

Kappa statistics have been widely used in the pathology literature to compare interobserver diagnostic variability (IOV) among different pathologists but there has been limited discussion about the clinical significance of kappa scores. Five representative and recent pathology papers were queried using clinically relevant specific questions to learn how IOV was evaluated and how the clinical applicability of results was interpreted. The papers supported our anecdotal impression that pathologists usually assess IOV using Cohen's or Fleiss' kappa statistics and interpret the results using some variation of the scale proposed by Landis and Koch. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151561DOI Listing

Clinicopathological features of 50 mismatch repair (MMR)-deficient endometrial carcinomas, tested by immunohistochemistry: A single institutional feasibility study, India.

Ann Diagn Pathol 2020 Jun 20;47:151558. Epub 2020 Jun 20.

Department of Radiation Oncology (Gynecology, Disease Management group), Tata Memorial Hospital, HBNI University, Mumbai, India.

There are few comprehensive studies from Asia on clinicopathologic features of mismatch repair (MMR)-deficient endometrial carcinomas, including rarely from our country. One hundred and four cases of endometrial carcinomas were tested for four MMR proteins by immunohistochemistry. Among 50 MMR-deficient (MMRd) tumors(48%), age-range was 27-68 years(median = 53) and tumor size(n = 34) varied from 1. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151558DOI Listing

Novel FEMASK-score, a histopathologic assessment for destructive Charcot neuropathic arthropathy, reveals intraneural vasculopathy and correlates with progression and best treatment.

Ann Diagn Pathol 2020 Mar 23;47:151509. Epub 2020 Mar 23.

Penn State College of Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Orthopedic Surgery, Hershey, PA, USA.

Background: Charcot neuropathic arthropathy is a debilitating, rapidly destructive degenerative joint disease that occurs in diabetic, neuropathic midfoot. Clinicoradiologic assessment for Charcot neuropathic arthropathy previously relied on Eichenholtz stage. There is limited histopathologic data on this entity. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151509DOI Listing

CRABP2 and FABP5 expression levels in diseased and normal pancreas.

Ann Diagn Pathol 2020 Jun 20;47:151557. Epub 2020 Jun 20.

Centre for Tumour Biology, Barts Cancer Institute - a CR-UK Centre of Excellence, Queen Mary University of London, Charterhouse Square, EC1M 6BQ London, UK; Barts and the London HPB Centre, Department of Surgery and Pathology, Barts Health NHS Trust, The Royal London Hospital, London E1 1BB, UK. Electronic address:

Recently, stromal targeting, by agents such as All trans retinoic acid (ATRA), has been regarded as a promising avenue for the treatment of pancreatic ductal adenocarcinoma (PDAC). The intra-cellular transportation of ATRA to the nuclear receptors is performed by either: fatty acid binding protein 5 (FABP5) or cellular retinoic acid binding protein 2 (CRABP2), dictating the transcription of downstream genes and, thus, eventual cell phenotype. Here, we explored the levels of each protein, in pancreatic tissues of patients presenting with a range of pancreatic diseases (pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), cholangiocarcinoma (CC)). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151557DOI Listing

Lesions of anogenital mammary-like glands: Four cases including novel pathologic and immunohistochemical observations.

Ann Diagn Pathol 2020 Jun 17;47:151551. Epub 2020 Jun 17.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA. Electronic address:

Anogenital mammary-like glands, formerly described as ectopic breast tissue, are currently considered to be normal histologic components of the anogenital region. Anogenital mammary-like glands can give rise to many lesions identical to counterparts in the native female breast. We describe four cases of such lesions, including fibroadenoma, gynecomastia-like hyperplasia, and ectopic mammary-type tissue with a spectrum of usual ductal hyperplasia, apocrine metaplasia, adenosis, and pseudolactational change. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151551DOI Listing

Comparison of Estrogen receptors, Progesterone receptors and HER2-neu immunohistochemistry results in breast cancer with those of Oncotype Dx.

Ann Diagn Pathol 2020 Jun 20;47:151556. Epub 2020 Jun 20.

Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan.

Oncotype Dx (ODx) recurrence score (RS) is used in early breast cancer to guide the use of adjuvant therapy. In addition to RS the test produces results of reverse transcriptase-polymerase chain reaction (RT-PCR) of Estrogen receptors (ER), Progesterone receptors (PgR) and Human epidermal growth factor receptor 2 (HER2-neu). Our goal was to determine the correlation between immunohistochemistry (IHC) and RT-PCR testing of ER, PgR and HER2-neu and to correlate the results of ODx RS with tumors' grade, age and PgR status. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151556DOI Listing
June 2020
1.112 Impact Factor

Non-random adenomatoid tumours of the female genital system: A comparative clinicopathologic analysis of 14 cases.

Ann Diagn Pathol 2020 Jun 17;47:151553. Epub 2020 Jun 17.

Department of Pathology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey. Electronic address:

The aim of this study was to evaluate adenomatoid tumours (AT) clinicopathologically in the female genital tract and compare the histomorphological features of ATs according to their uterine or tuba-ovarian location. Cases of AT were excised and collected from female genital tracts between the years of 2010-2017. Cases were evaluated depending on their clinical findings, localisation and pathological properties. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151553DOI Listing

Renal angiomyolipoma: Clinico-pathologic study of 17 cases with emphasis on the epithelioid histology and p53 gene abnormalities.

Ann Diagn Pathol 2020 May 23;47:151538. Epub 2020 May 23.

Department of Pathology, Sfax University Medical Center, Sfax 3029, Tunisia.

Background: Epithelioid angiomyolipoma (EAML) is a rare potentially malignant variant of renal angiomyolipoma (RAML). This study aims to determine whether RAML clinico-pathologic and molecular features (i.e. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151538DOI Listing
May 2020
1.112 Impact Factor

The utility of immunohistochemical testing for mismatch repair proteins in fine needle aspiration specimens of pancreatic adenocarcinoma.

Ann Diagn Pathol 2020 Jun 17;47:151552. Epub 2020 Jun 17.

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, United States of America. Electronic address:

Introduction: Microsatellite instability (MSI) testing is recommended for all colonic and endometrial carcinomas to screen for Lynch syndrome. The role of MSI testing in pancreatic adenocarcinoma has not been well-established. Screening can be done via immunohistochemical (IHC) staining for mismatch repair (MMR) proteins (MLH1, MSH2, MSH6, PMS2). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151552DOI Listing

Quantitative analysis of p16 methylation in Barrett's carcinogenesis.

Ann Diagn Pathol 2020 Jun 17;47:151554. Epub 2020 Jun 17.

CIBERehd, Instituto de Salud Carlos III, Calle Monforte de Lemos 3-5, 28029 Madrid, Spain; IIS Aragón, Instituto de Investigación Sanitaria Aragón, Avenida San Juan Bosco 13, 50009 Zaragoza, Spain; IACS Aragón, Instituto Aragonés de Ciencias de la Salud, Avenida San Juan Bosco 13, 50009 Zaragoza, Spain. Electronic address:

p16 hypermethylation in Barrett's carcinogenesis has been evaluated in studies which did not take into account sample heterogeneity and yielded qualitative (methylated/unmethylated) instead of accurate quantitative (percentage of CpG methylation) data. We aimed to measure the degree of p16 methylation in pure samples representing all the steps of Barrett's tumorogenesis and to evaluate the influence of sample heterogeneity in methylation analysis.

Methods: 77 paraffin-embedded human esophageal samples were analyzed. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151554DOI Listing

Is it mycosis fungoides? A comprehensive guide to reaching the diagnosis and avoiding common pitfalls.

Authors:
Ahmed Alsayyah

Ann Diagn Pathol 2020 Jun 6;47:151546. Epub 2020 Jun 6.

Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, Post Box No. 1982, Dammam 31441, Saudi Arabia. Electronic address:

Mycosis Fungoides (MF) is known as 'the great mimicker' due to its capacity to emulate several dermatoses, both in the clinic and on histology. This often leads to the diagnosis being missed or delayed, which consequently leads to poorer prognosis. For a timely diagnosis, it is crucial that the physician is aware of the various clinical and histological presentations of MF, as well as the proper diagnostic protocols. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151546DOI Listing

Automated quantification and architectural pattern detection of hepatic fibrosis in NAFLD.

Ann Diagn Pathol 2020 Apr 12;47:151518. Epub 2020 Apr 12.

Department of Computer and Information Science, Indiana University Purdue University, Indianapolis, IN, United States of America.

Accurate detection and quantification of hepatic fibrosis remain essential for assessing the severity of non-alcoholic fatty liver disease (NAFLD) and its response to therapy in clinical practice and research studies. Our aim was to develop an integrated artificial intelligence-based automated tool to detect and quantify hepatic fibrosis and assess its architectural pattern in NAFLD liver biopsies. Digital images of the trichrome-stained slides of liver biopsies from patients with NAFLD and different severity of fibrosis were used. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151518DOI Listing

Degos disease: A radiological-pathological correlation of the neuroradiological aspects of the disease.

Ann Diagn Pathol 2020 May 30;47:151545. Epub 2020 May 30.

Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States of America.

Malignant atrophic papulosis (Degos disease) is an unusual thrombotic microangiopathy of uncertain etiology. The disease characteristically involves the skin and internal organs, with nervous system involvement more common in children. We present a case with diverse neurological manifestations including cranial nerve palsies, gait instability, and urinary incontinence. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151545DOI Listing

Histologic diagnosis of a case of anal duct carcinoma with cytological correlation and differential diagnoses.

Ann Diagn Pathol 2020 May 20;47:151535. Epub 2020 May 20.

Department of Pathology and Anatomical Sciences, University of Missouri, United States of America.

Anal duct carcinoma is an uncommon malignancy of the glands of the anal duct. This entity poses a diagnostic challenge, both clinically and histologically. This article describes histopathologic findings in a case of anal duct carcinoma, including the initial diagnosis on biopsy and subsequent cytology specimens. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151535DOI Listing

Complexities in the diagnosis of large B-cell lymphomas, classic Hodgkin lymphomas and overlapping peripheral T-cell lymphomas simplified: An evidence-based guide.

Ann Diagn Pathol 2020 May 15;46:151534. Epub 2020 May 15.

Department of Pathology, University of California, San Francisco, CA 94143, United States of America. Electronic address:

The diagnosis of a large B-cell lymphoma and classic Hodgkin lymphoma (CHL) is often straightforward. However, in select circumstances, these simple diagnoses can be quite complex. In part, diagnostic difficulty may be due to uncertainty in the evaluation of morphologic and immunophenotypic features along a biologic continuum, or alternatively arise from uncertainty in predicting the behavior and outcomes of patients. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151534DOI Listing

The spectrum of muscle pathologies: Three decades of experience from a reference laboratory in Saudi Arabia.

Ann Diagn Pathol 2020 Apr 28;47:151532. Epub 2020 Apr 28.

King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdulaziz Medical City, Jeddah, Saudi Arabia. Electronic address:

Background: When investigating patients with a suspected neuromuscular disorder, a muscle biopsy is considered an instrumental tool to reach a definitive diagnosis. There is a paucity of publications that assess the diagnostic utilization and yield of muscle biopsies. We intend to present our experience in this regard over an extended period of more than three decades. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151532DOI Listing
April 2020
1.112 Impact Factor

Mucosal Schwann cell hamartoma of the gastroesophageal junction: A series of 6 cases and comparison with colorectal counterpart.

Ann Diagn Pathol 2020 Apr 28;47:151531. Epub 2020 Apr 28.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States. Electronic address:

Mucosal Schwann cell hamartoma (MSCH) is an uncommon neural lesion characterized by an ill-defined proliferation of S100-positive Schwann cells in the lamina propria, with reported cases exclusively occurring in the colorectum. Here we describe the first series of MSCHs arising in the gastroesophageal junction (GEJ) and discuss their clinicopathologic features in comparison with their colorectal counterparts. We searched the UCLA pathology database from 01/2014 to 12/2018 to identify cases carrying the diagnosis of MSCH. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151531DOI Listing
April 2020
1.112 Impact Factor

Oral manifestations of Langerhans cell histiocytosis with unusual histomorphologic features.

Ann Diagn Pathol 2020 May 21;47:151536. Epub 2020 May 21.

Oral and Dental Surgery Unit, Rashid Hospital, Dubai, United Arab Emirates.

Langerhans cell histiocytosis (LCH) is a bone marrow-derived immature myeloid dendritic cell proliferative disorder with diverse clinical manifestations commonly involves bone, skin, lymph node and lung. Oral involvement is uncommon. Intraoral lesions can be the first sign of either a localized LCH or clinically undiagnosed systemic LCH, predates systemic manifestations of LCH, or an early indicator of recurrence in known cases. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151536DOI Listing

Abundant CD8+ tumor infiltrating lymphocytes and beta-2-microglobulin are associated with better outcome and response to interleukin-2 therapy in advanced stage clear cell renal cell carcinoma.

Ann Diagn Pathol 2020 May 19;47:151537. Epub 2020 May 19.

Oregon Health & Science University, Department of Pathology, Portland, OR 97239, United States of America. Electronic address:

Studies assessing tumor-infiltrating lymphocytes (TILs) in clear cell renal cell carcinoma (ccRCC) and clinical outcomes have mixed results. Given fundamental interaction of MHC class I with CD8+ T-cells, we hypothesized that expression of MHC class I associated protein, beta-2-microglobulin (B2M), may be an important immunologic marker in RCC. We sought to understand potential implications of CD8 + TILs and tumor B2M expression on overall survival and response to high-dose interleukin-2 (IL-2) therapy, in a cohort of patients with high-stage (clinical stage III and IV) ccRCC. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151537DOI Listing

Non-small cell lung carcinomas with CTNNB1 (beta-catenin) mutations: A clinicopathological study of 26 cases.

Ann Diagn Pathol 2020 Apr 20;46:151522. Epub 2020 Apr 20.

Department of Pathology, Marie Lannelongue Hospital, 133 avenue de la Résistance, 92350 Le Plessis Robinson, France.

Beta-catenin, encoded by the CTNNB1 gene, plays an important role in cell proliferation. Mutations of CTNNB1 are oncogenic in several tumor types and are often associated with a nuclear abnormal expression. However, such mutations have only rarely been reported in non-small cell lung carcinomas and their clinical signification is not well described. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151522DOI Listing

Detection of cryptic CCND1 rearrangements in mantle cell lymphoma by next generation sequencing.

Ann Diagn Pathol 2020 May 6;46:151533. Epub 2020 May 6.

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

The accurate detection of recurrent genetic abnormalities for most hematologic neoplasms is critical for diagnosis, prognosis and/or treatment. Rearrangements involving CCND1 are observed in a subset of mature B-cell neoplasms and can be reliably detected by fluorescence in situ hybridization (FISH) in most cases. However, cryptic and complex chromosomal rearrangements may pose a technical challenge for accurate diagnosis. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151533DOI Listing

Morphological features useful in the differential diagnosis between undifferentiated carcinoma and gastrointestinal stromal tumor.

Ann Diagn Pathol 2020 May 3;46:151527. Epub 2020 May 3.

Sikl's Institute of Pathology, Faculty of Medicine and Teaching Hospital in Plzen, Charles University, Plzen, Czech Republic; Bioptical Laboratory, Ltd., Plzen, Czech Republic. Electronic address:

Undifferentiated (sarcomatoid) carcinomas may closely mimic gastrointestinal stromal tumors (GISTs) due to possible histological and immunohistochemical overlap between these two entities. To avoid unnecessary employment of a wide spectrum of immunohistochemical stainings and molecular genetics and thus decrease costs, finding simple morphological features to target further investigation of such neoplasms of the gastrointestinal tract would be helpful. Five cases classified as undifferentiated (sarcomatoid) carcinomas with a definite proof of the diagnosis, i. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151527DOI Listing

Are polyploid giant cancer cells in high grade serous carcinoma of the ovary blastomere-like cancer stem cells?

Ann Diagn Pathol 2020 Mar 18;46:151505. Epub 2020 Mar 18.

Baylor University Medical Center, Department of Pathology, 3600 Gaston Avenue, Dallas, TX 75246, United States of America; University of Texas MD Anderson Cancer Center, Department of Pathology, 1515 Holcombe Blvd. Unit 0072, Houston, TX 77030, United States of America. Electronic address:

Polyploid giant cancer cells, either multinucleated or mononucleated, in high grade serous carcinoma of the ovary have been previously recognized. Different theories including degenerative changes or an important step in the development of high grade serous carcinoma have been proposed. Here we investigate possible explanations for the presence of polyploid giant cancer cells in high grade serous carcinoma. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151505DOI Listing

Analysis of complement deposition and viral RNA in placentas of COVID-19 patients.

Ann Diagn Pathol 2020 Apr 25;46:151530. Epub 2020 Apr 25.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, United States of America. Electronic address:

COVID-19, the disease caused by the novel Coronavirus, SARS-CoV-2, is increasingly being recognized as a systemic thrombotic and microvascular injury syndrome that may have its roots in complement activation. We had the opportunity to study the placental pathology of five full-term births to COVID-19 patients. All five exhibited histology indicative of fetal vascular malperfusion characterized by focal avascular villi and thrombi in larger fetal vessels. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182529PMC

WITHDRAWN: A mechanistic analysis placental intravascular thrombus formation in COVID-19 patients.

Ann Diagn Pathol 2020 Apr 25;46:151529. Epub 2020 Apr 25.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195270PMC

Prognosis in pathology: Are we "prognosticating" or only establishing correlations between independent variables and survival? A study with various analytics cautions about the overinterpretation of statistical results.

Ann Diagn Pathol 2020 Apr 21;46:151525. Epub 2020 Apr 21.

Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

Survival data from 225 patients with resected pulmonary typical carcinoids were analyzed with Kaplan-Meier statistics (K-M) and "deep learning" methods to illustrate the difference between establishing "correlations" and "prognostications". Cases were stratified into G1 and G2 classes using a ≤5% Ki-67% cut-point. Overall survival, number of patients at risk and 95% confidence intervals (CI) were estimated for the two classes. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151525DOI Listing

Central giant cell granuloma: A clinicopathological and immunohistochemical study of macrophages, blood vessels, lymphatic vessels and regulatory proteins.

Ann Diagn Pathol 2020 Apr 20;46:151526. Epub 2020 Apr 20.

Dentistry and Health Postgraduate Program, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil; Laboratory of Oral and Maxillofacial Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil. Electronic address:

Objective: This study seeks to investigate immunohistochemical parameters that could distinguish non-aggressive Central giant cell granuloma (CGCG) from aggressive CGCG, two groups of lesions which differ in their clinical and radiographic features and prognosis.

Material And Methods: 12 cases of non-aggressive CGCG and 11 cases of aggressive CGCG were investigated and associated the immunohistochemical expression of macrophages (CD68 and CD163), blood vessels (CD34 and CD105), lymphatic vessels (D2-40) and regulator proteins (p63 and Ki-67). Clinical and radiographic features were also studied. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151526DOI Listing

From the archives of MD Anderson Cancer Center: BCR-ABL1-like B acute lymphoblastic leukemia with IGH/EPOR fusion.

Ann Diagn Pathol 2020 Apr 15;46:151514. Epub 2020 Apr 15.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151514DOI Listing
April 2020
1.112 Impact Factor

A broad-based approach to differentiate CIN from its mimics: The utility of in situ hybridization and immunohistochemistry.

Authors:
Gerard Nuovo

Ann Diagn Pathol 2020 Apr 13;46:151515. Epub 2020 Apr 13.

The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States of America; Discovery Life Sciences, Powell, OH, United States of America. Electronic address:

The hematoxylin and eosin slides of 100 consecutive cases diagnosed as CIN 1-2 were combined with 25 CIN 1 and 25 negative for CIN as documented by in situ HPV testing. The 150 cases were then reviewed blinded and scored as "CIN" or "negative for CIN". Each of the 50 controls was correctly scored. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151515DOI Listing

mTOR pathway activation in focal cortical dysplasia.

Ann Diagn Pathol 2020 Apr 10;46:151523. Epub 2020 Apr 10.

Institute of Genomics and Integrative Biology - Council of Scientific and Industrial Research, New Delhi, India.

Background: Focal cortical dysplasia (FCD) is a localized cortical malformation and considerable morphological overlap exists between FCD IIB and neurological lesions associated with Tuberous sclerosis complex (TSC). Abnormal mTOR pathway secondary to somatic mTOR mutation and TSC gene mutation linked to PI3K/AKT/mTOR pathway have supported the hypothesis of common pathogenesis involved. Role of converging pathway, viz. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151523DOI Listing

B-cell lymphomas associated with breast implants: Report of three cases and review of the literature.

Ann Diagn Pathol 2020 Mar 28;46:151512. Epub 2020 Mar 28.

Department of Medicine, Hematology/Oncology Division, University of California Irvine (UCI) Medical Center, Orange, CA, United States of America. Electronic address:

Since the first reported case in 1997, over 600 women with breast implant-associated anaplastic large cell lymphoma (BI ALCL) have been reported. BI ALCL is a CD30-positive T-cell lymphoma that carries clonal T-cell receptor gene rearrangements, and a subset of cases harbors mutations in the JAK-STAT signaling pathway. Rarely, other histologic types of lymphoma have been reported in association with breast implants, including fewer than 10 cases of B-cell origin. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151512DOI Listing

Pediatric clear cell meningioma involving the middle cranial fossa in the context of NF2 and SMARCE1 mutations.

Ann Diagn Pathol 2020 Apr 13;46:151516. Epub 2020 Apr 13.

Cleveland Clinic Lerner College of Medicine and Cleveland Clinic Department of Anatomic Pathology, Cleveland, OH, United States of America. Electronic address:

Meningiomas are an uncommon entity in children and adolescents. <30 cases of pediatric clear cell meningioma (CCM), a World Health Organization (WHO) Grade II tumor, have been reported in the literature. These tumors are more likely to recur than the more common WHO Grade I meningiomas, especially with incomplete surgical resection. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151516DOI Listing

1p/19q co-deleted fibrillary astrocytomas: Not everything that is co-deleted is an oligodendroglioma.

Ann Diagn Pathol 2020 Apr 8;46:151519. Epub 2020 Apr 8.

University School and Cleveland Clinic Department of Anatomic Pathology, USA. Electronic address:

The presence of chromosome 1p/19q co-deletion is one of the hallmark required criteria for the diagnosis of oligodendroglioma, using the 2016 World Health Organization (WHO) Classification of Tumours of the Central Nervous System. Descriptions in the literature of astrocytomas, primarily glioblastomas, demonstrating partial losses on one or the other chromosome have been described. The significance of these small deletions is uncertain. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151519DOI Listing

Metastatic atypical meningioma to the parotid gland - A cytopathological correlation.

Ann Diagn Pathol 2020 Apr 6;46:151521. Epub 2020 Apr 6.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States of America. Electronic address:

The tumors involving the parotid gland are mainly primary, with metastatic lesions comprising only 5% of malignant salivary gland neoplasms. We are presenting a rare case of metastatic meningioma to the parotid in a 51-year-old male with a past medical history of recurrent atypical meningioma involving the frontal lobe. For the past 1. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151521DOI Listing

Evaluation of deeper levels in initially negative temporal artery biopsies and likelihood of a positive result.

Ann Diagn Pathol 2020 Apr 8;46:151517. Epub 2020 Apr 8.

Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, OH 44195, USA. Electronic address:

Giant cell arteritis is a vasculitis that affects large- and medium-sized vessels in patients over the age of 50 years. The demonstration of granulomatous arteritis is the criterion standard to establish a definitive diagnosis. However, temporal arteritis is known to discontinuously involve the artery, and there is no standardization of the number of sections which should be examined in a length of sampled artery. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151517DOI Listing

The expression and prognostic role of IMPDH2 in ovarian cancer.

Ann Diagn Pathol 2020 Mar 23;46:151511. Epub 2020 Mar 23.

Cangzhou Medical College, Cangzhou City, Hebei Province 061001, China. Electronic address:

Object: Inosine 5'-monophosphate dehydrogenase type II (IMPDH2), as an oncogene, is reported to be involved in tumor formation and progression. However, the role of IMPDH2 in ovarian cancer remains unclear. Present study is aimed to investigate the expression and clinical significance of IMPDH2 in ovarian cancer. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151511DOI Listing

Should we perform cytokeratin immunostaining in cases of Russell body gastritis?

Ann Diagn Pathol 2020 Apr 6;46:151524. Epub 2020 Apr 6.

Department of General and Clinical pathology, Medical University, Plovdiv, Bulgaria; Service d'Anatomie et Cytologie Pathologiques, Grand Hôpital de l'Est Francilien, Jossigny, France.

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151524DOI Listing

Mapping of parathyroid neoplasms based on grey scale ultrasound images and histopathological whole slide images.

Ann Diagn Pathol 2020 Mar 3;46:151492. Epub 2020 Mar 3.

Department of Endocrinology and Metabolism, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.

Purpose: In this study, echogenicity and histopathological projections of parathyroid neoplasia in grey mode ultrasonography were compared with whole side imaging (WSI). The utility of the data obtained for clinical assessment was evaluated.

Methods: In 57 patients operated for hyperparathyroidism, the parathyroid gland was sampled in the sagittal plane. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151492DOI Listing

An investigation of European pathologists' approach to diagnose microscopic colitis.

Ann Diagn Pathol 2020 Apr 5;46:151520. Epub 2020 Apr 5.

Department of Pathology, Zealand University Hospital Roskilde, Sygehusvej 9, 4000 Roskilde, Denmark.

Microscopic colitis (MC) comprising lymphocytic colitis (LC), collagenous colitis (CC) and the incomplete forms of microscopic colitis (MCi) are frequent causes of chronic watery diarrhea. The diagnosis is based on specific histological features in colonic biopsies. Especially regarding MCi, the histological features may be subtle. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151520DOI Listing

SATB2 is frequently expressed in ossifying and non-ossifying peripheral oral fibroma of the gingival region but not in reactive fibromatous lesions from other intraoral sites.

Ann Diagn Pathol 2020 Apr 2;46:151510. Epub 2020 Apr 2.

Institute of Pathology, University Hospital, Erlangen, Germany.. Electronic address:

Ossifying and non-ossifying peripheral oral fibromas (POF) of the gingival and alveolar mucosa are localized, cellular, small fibrous nodular lesions likely resulting from diverse external/ internal physical and chemical irritation or injuries. A central nidus of metaplastic woven bone characterizes and defines the ossifying variant. The inherent tendency of these lesions to ossify remains elusive. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151510DOI Listing

Sinonasal papillomas: A single centre experience on 137 cases with emphasis on malignant transformation and EGFR/KRAS status in "carcinoma ex papilloma".

Ann Diagn Pathol 2020 Mar 13;46:151504. Epub 2020 Mar 13.

Institute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), University Hospital, Erlangen, Germany. Electronic address:

Among the three major histological subtypes of sinonasal papillomas, inverted (ISP) and oncocytic (OSP) sinonasal papillomas tend to undergo malignant transformation to carcinoma. However, criteria determining risk of recurrence and malignant progression have not been established. Recently, EGFR and KRAS mutations were detected to be characteristic for ISP and OSP, respectively. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151504DOI Listing
March 2020
1.112 Impact Factor

Benign vascular anomalies: A transition from morphological to etiological classification.

Ann Diagn Pathol 2020 Mar 13;46:151506. Epub 2020 Mar 13.

Department of Radiodiagnosis, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi 110031, India.

The International Society for the Study of Vascular Anomalies (ISSVA) devised a multidisciplinary etiopathogenesis based approach to classify benign vascular anomalies into tumors and malformations. This classification scheme has major therapeutic and prognostic implications as treatment modalities differ for both the categories. Inappropriate usage of the term "hemangioma" for etiopathogenetically distinct entities is commonly seen in clinical practice leading to delivery of incorrect treatment to the patients. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151506DOI Listing
March 2020
1.112 Impact Factor

Prolactin receptor expression as a novel prognostic biomarker for triple negative breast cancer patients.

Ann Diagn Pathol 2020 Mar 13;46:151507. Epub 2020 Mar 13.

Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.

Prolactin receptor (PRLR) is a novel emerging prognostic biomarker in different cancers, especially in breast cancer. However, there is limited information about the association of PRLR expression and triple-negative breast cancers (TNBC) prognosis. In this study, 80 TNBC patients were evaluated for PRLR expression by immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151507DOI Listing

Presence of tumor cells in the vagina during surgical treatment could be the source of vaginal recurrence in patients with endometrial carcinoma - A pilot prospective study.

Ann Diagn Pathol 2020 Mar 13;46:151503. Epub 2020 Mar 13.

Department of Pathology, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

Background: The commonest site of recurrence in endometrial cancer (EC) is the vagina, with a rate of 16%. The aim of this study was to determine if vaginal recurrences in EC patients could develop due to contamination of the vagina with glandular tumor cells dropping off on polypoid, large size EC or tumors involving the endocervix, through manipulation of the uterus during surgery.

Methods: This pilot prospective study included 10 consecutive patients with EC, surgically treated with hysterectomy and additional lymphadenectomy according to stage. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151503DOI Listing

Clinical and histopathologic characteristics of patients undergoing surgical excision with Essure coils: Longitudinal experience at a women's specialty hospital.

Authors:
Natalie Banet

Ann Diagn Pathol 2020 Mar 13;46:151508. Epub 2020 Mar 13.

Department of Pathology and Laboratory Medicine, Women & Infants Hospital and the Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA.. Electronic address:

The introduction of the Essure (Bayer AG, Leverkusen, Germany) device made possible a less invasive approach for patients desiring sterilization. Following FDA approval in 2002, problems were reported in some patients with these devices including most commonly pain. Labeling changes were mandated in 2016, and as of late 2018, the devices are no longer being sold in the United States. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151508DOI Listing

Histological subtypes in triple negative breast cancer are associated with specific information on survival.

Ann Diagn Pathol 2020 Mar 3;46:151490. Epub 2020 Mar 3.

Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.

Much research has focused on finding novel prognostic biomarkers for triple negative breast cancer (TNBC), whereas only scattered information about the relation between histopathological features and survival in TNBC is available. This study aims to explore the prognostic value of histological subtypes in TNBC. A multicenter retrospective TNBC cohort was established from five Dutch hospitals. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151490DOI Listing