18,070 results match your criteria Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy


PD-1 Polymorphisms Are Associated with Susceptibility of Acute Anterior Uveitis in Chinese Population.

DNA Cell Biol 2018 Dec 12. Epub 2018 Dec 12.

1 The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and Optometry, Wenzhou Medical University , Wenzhou, Zhejiang, China .

Acute anterior uveitis (AAU) is an ordinary type of uveitis, which is an autoimmune disease produced by T cells. Programmed apoptosis protein 1 (PD-1) is a vital negative regulatory protein of immune tolerance. We detect the single nucleotide polymorphisms (SNPs) rs41386349, rs10204525, and rs2227982 of PD-1 to investigate the correlation between PD-1 polymorphisms and AAU. Read More

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December 2018

Safety of dual biological therapy in Crohn's disease: a case series of vedolizumab in combination with other biologics.

BMJ Open Gastroenterol 2018 9;5(1):e000243. Epub 2018 Nov 9.

Department of Medicine, Division of Gastroenterology, University of California, San Francisco, San Francisco, California, USA.

Uncertainty exists regarding safety and efficacy of dual biological therapy (DBT) in inflammatory bowel disease. We present four cases of DBT in Crohn's disease. Three patients had refractory disease non-responsive to biological monotherapy or combination therapy with immunomodulators. Read More

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November 2018

Lateral position and utility of navigation for posterior fixation of unstable cervical fracture with ankylosing spondylitis.

Surg Neurol Int 2018 2;9:225. Epub 2018 Nov 2.

Grant Medical Center, Department of Neurosurgery, Ohio Health, Columbus, Ohio, USA.

Background: Ankylosing spondylitis (AS) is a seronegative spondyloarthropathy within the spectrum of rheumatologic diseases. The systemic inflammation that characterizes AS leads to bone resorption and reformation. Pathologic remodeling may include kyphosis, osteoporosis, and multi-segment auto-fusion. Read More

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November 2018

Genetic Polymorphisms of G-Protein Coupled Receptor65 Gene are associated with Ankylosing Spondylitis in a Chinese Han population: a case-control study.

Hum Immunol 2018 Dec 4. Epub 2018 Dec 4.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. Electronic address:

Objective: This study aimed to assess the association between two tag single nucleotide polymorphisms (SNPs) (rs68177277 and rs11624293) of G-protein coupled receptor 65 (GPR65) gene and ankylosing spondylitis (AS) in a Chinese Han population.

Methods: 673 patients with AS diagnosed according to the modified New York criteria and 679 age- and gender-matched healthy controls were recruited. SNP genotyping for rs68177277 and rs11624293 polymorphisms were performed using the SNPscan technique. Read More

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December 2018

The Unstable Spine: A Surgeon's Perspective.

Semin Ultrasound CT MR 2018 Dec 13;39(6):618-629. Epub 2018 Oct 13.

Department of Orthopedic Surgery & Rehabilitation, University of Nebraska Medical Center, Omaha, NE.

Instability of the spine is a complex clinical entity that exists on a wide spectrum encompassing many aspects of spinal pathology including traumatic, neoplastic, infectious, and degenerative processes. The importance of determining stability is paramount in the decision-making process regarding the need for operative or nonoperative care. Defining clinical instability can be a challenging and requires careful attention to the pathology involved, findings of necessary imaging, and a thorough clinical exam. Read More

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December 2018

New bone formation in the intervertebral joint space in spondyloarthritis: An MRI study.

Eur J Radiol 2018 Dec 6;109:210-217. Epub 2018 Nov 6.

Department of Radiology and Medical Imaging, Ghent University Hospital, Corneel Heymanslaan 10, B-9000 Gent, Belgium. Electronic address:

Objectives: To study the presence of high signal intensity of the intervertebral disc, syndesmophytes, vertebral corner bridging and transdiscal ankylosis on spinal T1-weighted MR images in spondyloarthritis (SpA).

Methods: A retrospective case-control study of whole spine MRI examinations, obtained in 100 patients with axial SpA and in 100 control patients, was performed. All disco-vertebral units (DVUs) were analyzed on T1-weighted MR images for normal or high signal intensity of the intervertebral disc, presence of syndesmophytes, vertebral corner bridging or transdiscal ankylosis and correlated with final diagnosis. Read More

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December 2018

Spinal arachnoiditis ossificans: report of a quadruple triggered case.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurological Surgery, Policlinico "G. Rodolico" University Hospital, Via Santa Sofia 86, 95123 - Catania, Italy.

Background: Arachnoiditis ossificans (AO) is a rare condition often associated with previous spine surgery. Here we describe a unique case of a patient affected by ankylosing spondylitis (AS), presenting with progressive neurological deterioration due to AO. We also review the literature on evaluation and management of patients suffering from AO. Read More

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December 2018
2 Reads

Dendritic cells in the pathogenesis of ankylosing spondylitis and axial spondyloarthritis.

Clin Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

The interaction of dendritic cells (DCs) with the human microbiome, with distorted handling of the microbiota or its products via the direct effect of HLA B27, probably represents the initial element in the chain of events leading to the development of clinical axial spondyloarthritis. The mechanism of disease extension onto the skeleton and other tissues involved, such as uvea, may also involve migratory DCs. Finally, the role of DCs in the initiation of the inflammatory tissue response with activation of the IL-17 axis has been demonstrated. Read More

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December 2018
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Analysis of drug utilization and health care resource consumption in patients with psoriasis and psoriatic arthritis before and after treatment with biological therapies.

Biologics 2018 12;12:151-158. Epub 2018 Nov 12.

Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.

Objectives: To describe the therapeutic pathways of patients with psoriasis (PSO) and psoriatic arthritis (PsA) before and after treatment with biological therapies in a real-world setting and to determine the relative consumption of health care resources.

Design: Retrospective observational study.

Setting: Real-life clinical setting in 5 Italian local health units. Read More

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November 2018

Evaluation of ERAP1 Gene Single Nucleotide Polymorphism in Impressing the Inflammatory Cytokine Profile of Ankylosing Spondylitis Patients.

Iran J Allergy Asthma Immunol 2018 Oct 20;17(5):464-474. Epub 2018 Oct 20.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AND Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran AND Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Ankylosing spondylitis (AS), an autoinflammatory disease, has been associated with impaired Endoplasmic reticulum aminopeptidase (ERAP) 1 activity, which is involved in priming antigenic peptides. The purpose of this study was to evaluate if the genetic variant of ERAP1 gene could impress the inflammation status of the AS patients. For genotyping, 140 AS cases and 140 healthy controls were enrolled. Read More

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October 2018

A Drug with Lipophilicity-Dependent Potency Can Be Metabolically Stable: Discovery of a Potent and Selective Retinoic Acid Receptor-Related Orphan Receptor C2 (RORC2) Inverse Agonist as an Orally Bioavailable Anti-Inflammatory Agent.

J Med Chem 2018 Dec 3. Epub 2018 Dec 3.

State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.

IL-17 drives an amplification mechanism in inflammatory diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis. The production of IL-17 depends on the activity of RORC2 in immune cells, which suggests that RORC2 inverse agonists are capable of anti-inflammatory therapy by reducing IL-17 levels. However, oral delivery of inverse agonists remains a challenge since the binding pocket of RORC2 prefers to accommodate lipophilic ligands, which tend to have poor metabolic stability. Read More

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December 2018

The Early Phases of Ankylosing Spondylitis: Emerging Insights From Clinical and Basic Science.

Front Immunol 2018 16;9:2668. Epub 2018 Nov 16.

Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, United Kingdom.

In our paper, we discuss how the early phases of ankylosing spondylitis (AS) are linked to peri-firbocartilagenous osteitis in the sacroiliac joint and entheseal bone related anchoring sites. This skeletal proclivity is linked to an abnormal immunological response to skeletal biomechanical stress and associated microdamage. A key event in the early stages of AS appears to be the association with subclinical Crohn's-like colitis with this gut inflammation being pivotal to the osteitis reaction. Read More

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November 2018
2 Reads

Hyperthermia in rheumatic diseases. A promising approach?

Reumatologia 2018 31;56(5):316-320. Epub 2018 Oct 31.

Department of Gerontology, Public Health, and Didactics, National Institute of Geriatrics, Rheumatology, and Rehabilitation, Warsaw, Poland.

Hyperthermia is a method applied in the treatment of many diseases, including rheumatic diseases. There are relatively few reports concerning the role of that method in the treatment of these diseases, and most studies have not been randomised. Hyperthermia includes directed application of thermal energy. Read More

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October 2018

A Retrospective Observational Study of Uveitis in a Single Center in Poland with a Review of Findings in Europe.

Med Sci Monit 2018 Dec 3;24:8734-8749. Epub 2018 Dec 3.

Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND This study aimed to review the causes, presentation, and clinicopathological associations of uveitis in a single department of ophthalmology in Poland, and to compare the findings with previously published studies from other European countries. MATERIAL AND METHODS Review of local patient records between 2005-2015 identified patients diagnosed with uveitis. Data obtained included age, gender, imaging findings, and laboratory diagnostic findings. Read More

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December 2018
3 Reads

Pulmonary high-resolution computed tomography findings in patients with synovitis, acne, pustulosis, hyperostosis and osteitis syndrome.

PLoS One 2018 5;13(12):e0206858. Epub 2018 Dec 5.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Objective: To characterize the high-resolution computed tomography (HRCT) pulmonary abnormalities in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.

Methods: Pulmonary HRCT images were reconstructed from whole-spine computed tomography (CT) images of 67 patients with SAPHO syndrome. HRCT images of 58 healthy controls were also obtained and reviewed. Read More

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December 2018

Corrigendum to "The Protective Effect of Extract against Ankylosing Spondylitis in Mouse Models".

Biomed Res Int 2018 1;2018:8097342. Epub 2018 Nov 1.

Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

[This corrects the article DOI: 10.1155/2017/8206281.]. Read More

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November 2018

Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors.

J Clin Med 2018 Dec 1;7(12). Epub 2018 Dec 1.

Rheumatology Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.

The prevalence of sarcopenia in rheumatic diseases has been evaluated in single diseases using various diagnostic approaches, generating conflicting data on the pathogenetic mechanism(s). Herein, we evaluated both muscle mass index (MMI) and muscle strength to assess sarcopenia and presarcopenia in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Moreover, we evaluated the possible impact of disease/patient-related characteristics, therapeutic regimens, and nutritional aspects on sarcopenia. Read More

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December 2018

[Vitamin D3 regulates mononuclear phagocyte polarization induced by serum from patients with ankylosing spondylitis].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):389-394

Department of Rheumatism and Immunology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.

Objective: To investigate the effect of vitamin D3 on polarization of monocyte macrophages induced by serum from patients with ankylosing spondylitis (AS).

Methods: Twenty AS naïve patients and 20 healthy controls from Wenzhou People's Hospital during January 2016 and December 2017 were enrolled. The macrophages were differentiated from THP1 cells induced by phorbol 12-myristate 13-acetate (PMA), and then co-cultured with the serum from healthy subjects (control group) or AS patients. Read More

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February 2018

Foot functions in ankylosing spondylitis.

Clin Rheumatol 2018 Dec 3. Epub 2018 Dec 3.

Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Turkey.

Abtract: AIM: Because of the wide diversity of developmental stages in spondyloarthropathies (SpA), clinical and radiographic weak correlations are often found in the development of enthesopathies. In this study, foot functions of ankylosing spondylitis (AS) patients were analyzed with clinical and radiological features.

Method: Sixty-two AS patients and 39 age-matched, gender-matched, and body mass index (BMI)-matched healthy volunteers were included in this study. Read More

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December 2018
4 Reads

The effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis.

Biologics 2018 8;12:143-149. Epub 2018 Nov 8.

Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Reade, Amsterdam, The Netherlands,

Background: Diastolic left ventricular (LV) dysfunction appears more prevalent in ankylosing spondylitis (AS). The effects of tumor necrosis factor alpha (TNF-α) blocking therapy, a strong and effective anti-inflammatory drug, on diastolic LV function in AS are unknown. The objective of the study was to find the effects of 1-year treatment with golimumab 50 mg subcutaneously once per month on systolic and diastolic LV dysfunction in AS patients. Read More

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November 2018
2 Reads

Born to run: The paradox of biomechanical force in spondyloarthritis from an evolutionary perspective.

Best Pract Res Clin Rheumatol 2017 12 1;31(6):887-894. Epub 2018 Sep 1.

Department of Rheumatology - MRB2, Ghent University Hospital, Corneel Heymanslaan 10, BE-9000, Ghent, Belgium; VIB Center for Inflammation Research, Ghent University, Ghent, Belgium. Electronic address:

Spondyloarthritis (SpA) refers to a group of chronic inflammatory arthritic diseases that can be severely debilitating. The most common form of SpA affecting the peripheral skeleton is psoriatic arthritis, while that affecting the axial skeleton is ankylosing spondylitis. SpA has a multifactorial nature, with both genetic and environmental factors initiating and maintaining the disease. Read More

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December 2017

Evolving concepts of new bone formation in axial spondyloarthritis: Insights from animal models and human studies.

Best Pract Res Clin Rheumatol 2017 12 20;31(6):877-886. Epub 2018 Sep 20.

Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada; Krembil Research Institute, University Health Network, University of Toronto, ON, Canada.

New bone formation potentially leading to ankylosis of the sacroiliac joints and the spine is the main type of structural damage to the skeleton that characterizes axial spondyloarthritis. New data from animal models, imaging, and patient cohort studies support the view that sustained suppression of inflammation by therapeutic interventions can slow down the ankylosing process, at least in a large proportion of the patients. Although specific growth factor molecular signaling pathways are the key to drive the progenitor cell differentiation process that leads to ankylosis, inflammation plays an important role, most likely in combination with biomechanical and environmental factors, in both the onset and progression of the disease. Read More

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December 2017

Gut inflammation in spondyloarthritis.

Best Pract Res Clin Rheumatol 2017 12 27;31(6):863-876. Epub 2018 Sep 27.

Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy. Electronic address:

Spondyloarthritis (SpA) is a group of related diseases sharing common etiopathogenic mechanisms and clinical manifestations supported by a complex genetic predisposition. Gut inflammation is present in patients with SpA including patients showing clinically evident intestinal inflammation in the form of Crohn's disease or ulcerative colitis and patients who despite the absence of signs and symptoms of intestinal inflammation display a subclinical gut inflammation. Emerging evidence suggests that subclinical gut inflammation in patients with SpA, apparently driven by intestinal dysbiosis, is not the consequence of the systemic inflammatory process but rather an important pathophysiological event actively participating in the pathogenesis of the disease. Read More

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December 2017

Uveitis and spondyloarthropathies.

Best Pract Res Clin Rheumatol 2017 12 25;31(6):846-862. Epub 2018 Oct 25.

Oxford Eye Hospital, John Radcliffe Hospital, Headley Way, Oxford, United Kingdom. Electronic address:

Uveitis is a frequently occurring extra-articular manifestation of spondyloarthropathies (SpAs), ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA) and inflammatory bowel disease (IBD), occurring in both adults and children with SpA. Uveitis occurs with varying frequency according to the SpA subtype (33% in AS, 6-9% in PsA, 25% in ReA, 13% in undifferentiated SpA and 2-5% in IBD), the presence of HLA-B27 and with increasing duration of disease. The majority of cases of uveitis in SpA are attributed to acute anterior uveitis but a minority of uveitis cases occur in the posterior segment of the eye. Read More

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December 2017

Pain in spondyloarthritis: A neuro-immune interaction.

Best Pract Res Clin Rheumatol 2017 12 17;31(6):830-845. Epub 2018 Aug 17.

Spondylitis Program, Department of Rheumatology, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada; Krembil Research Institute, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada; Department of Immunology, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada; Institute of Medical Science, Medical Sciences Building, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.

Pain in spondyloarthritis is usually attributed to inflammation. However, treatment with potent biologic agents that control inflammation does not always control the pain. Pain is hence likely to be multifactorial. Read More

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December 2017
1 Read

Nonradiographic axial spondyloarthritis.

Best Pract Res Clin Rheumatol 2017 12 2;31(6):816-829. Epub 2018 Nov 2.

University of California, San Francisco, 400 Parnassus Avenue, Box A094, San Francisco, CA, 94143, USA. Electronic address:

Non-radiographic axial spondyloarthritis (nr-axSpA) is a complex disease process that is part of the spectrum of axial spondyloarthritis (axSpA). This article reviews the current state of the literature as the understanding of this disease spectrum expands. The conceptual history and terminology, genetics, and epidemiology are reviewed. Read More

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December 2017

The role of HLA-B*27 in spondyloarthritis.

Best Pract Res Clin Rheumatol 2017 12 23;31(6):797-815. Epub 2018 Aug 23.

Pediatric Translational Research Branch, NIAMS Intramural Research Program, NIH, USA. Electronic address:

The mechanism by which HLA-B*27 predisposes to spondyloarthritis remains unresolved. Arthritogenic peptides have not been defined in humans and are not involved in experimental models of spondyloarthritis. Aberrant properties of HLA-B*27 can activate the IL-23/IL-17 axis in HLA-B*27 transgenic rats and humans. Read More

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December 2017
1 Read

Th17 cell responses in spondyloarthritis.

Best Pract Res Clin Rheumatol 2017 12 30;31(6):777-796. Epub 2018 Aug 30.

Cambridge University Hospitals NHSFT, Department of Medicine, University of Cambridge, UK.

Targeting IL-17 has become an important option in the current treatment of spondyloarthritis (SpA). To place this therapeutic advancement in context, we review the discovery and properties of this cytokine, noting those which predispose to inflammation and led to it being considered as an attractive target for the treatment of arthritis, especially SpA. The processes that regulate the differentiation of IL-17-producing cells, particularly Th17 CD4+ T cells, have been investigated thoroughly, including the role of IL-23, as these point to additional potential therapies as alternatives to direct IL-17 blockade. Read More

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December 2017

Genetics in ankylosing spondylitis - Current state of the art and translation into clinical outcomes.

Best Pract Res Clin Rheumatol 2017 12 3;31(6):763-776. Epub 2018 Oct 3.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Ankylosing spondylitis (AS) is the prototypic form of axial spondyloarthritis (axSpA). It is highly heritable, with studies conducted in twins and in unrelated cases and controls showing that the heritability for AS is much higher than those for inflammatory bowel disease or rheumatoid arthritis. To date, 116 loci have been identified, contributing to 28% of the genetic variation in the disease. Read More

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December 2017

Anti IL-17 monoclonal antibodies for the treatment of ankylosing spondylitis.

Expert Opin Biol Ther 2018 Nov 30. Epub 2018 Nov 30.

a Department of Rheumatology , CHRU de BESANCON, University Teaching Hospital , Besançon , France.

Introduction: Ankylosing spondylitis is the prototype of spondyloarthritis, a chronic inflammatory disease involving mainly the axial skeleton. The treatment strategy was, until now, restricted to NSAIDs and anti TNF agents. Targeting Interleukin 17 is an emerging option with a currently available biologic agent, secukinumab. Read More

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November 2018
1 Read

[Application of TNF-alpha inhibitors in treatment of uveitis associated with ankylosing spondylitis].

Vestn Oftalmol 2018 ;134(5. Vyp. 2):257-262

Russian Medical Academy of Postgraduate Education, Rheumatology Department, 2/1 Barrikadnaya St., Moscow, Russian Federation, 123995.

Uveitis is one of the most frequent extraskeletal manifestations of ankylosing spondylitis (AS). Despite iridocyclitis being the most prevalent form of uveitis in patients with AS, and the rareness of the involvement of posterior eye segments in the inflammatory process, the frequent exacerbation of the disease, a significant number of patients develop complications that lead to decrease of visual acuity. The review features theoretical prerequisites for application of tumor necrosis factor alpha (TNF-alpha) inhibitors: infliximab, adalimumab and etanercept. Read More

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January 2018
1 Read

Comparison Between INSPIRE and Domjan method for measuring lumbar lateral flexion in patients of psoriatic arthritis (PsA) and correlation with radiographic damage.

Clin Rheumatol 2018 Nov 29. Epub 2018 Nov 29.

Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

Objective: Assessment of spinal lateral flexion (SLF) is important in spondyloarthritis (SpA). The INSPIRE method of measuring SLF requires one set of measurements, is faster, feasible, and correlates with the mSASSS in ankylosing spondylitis. The present study aimed to compare the INSPIRE to Domjan method in PsA patients and correlate with radiographic changes. Read More

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November 2018
4 Reads

The Relationship of Ankylosing Spondylitis and Subclinical Atherosclerosis: A Systemic Review and Meta-Analysis.

Angiology 2018 Nov 29:3319718814309. Epub 2018 Nov 29.

1 Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, China.

Cardiovascular disease has become the first cause of death for patients with ankylosing spondylitis (AS). However, the relevant data is limited and the relationship between AS and subclinical atherosclerosis remains questionable. Therefore, we assessed the relationship between subclinical atherosclerosis and AS in this meta-analysis. Read More

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November 2018
2 Reads

Uncovering the heterogeneity of disease impact in axial spondyloarthritis: bivariate trajectories of disease activity and quality of life.

RMD Open 2018 14;4(2):e000755. Epub 2018 Nov 14.

Department of Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, The Netherlands.

Objective: The goal of managing axial spondyloarthritis (axSpA) is to improve and maintain patients' health-related quality of life (HRQoL), mainly through targeting towards low disease activity. Here, we aim to gain insight into the joint evolution of HRQoL and disease activity by identifying and characterising latent subgroups of patients with longstanding disease displaying similar trajectories throughout 8  years of follow-up.

Methods: Data from Outcome in Ankylosing Spondylitis (AS) International Study (n=161) and Groningen Leeuwarden AS cohort (n=264) were used. Read More

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November 2018
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Silencing SOCS3 Markedly Deteriorates Spondyloarthritis in Mice Induced by Minicircle DNA Expressing IL23.

Front Immunol 2018 14;9:2641. Epub 2018 Nov 14.

Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.

Despite extensive studies, the precise mechanism underlying spondyloarthritis, especially ankylosing spondylitis, remains elusive. This study aimed to develop an ideal animal model for an insight into mechanism of spondyloarthritis and functional relevance of SOCS3 in spondyloarthritis. Since SOCS3 is a major regulator of IL23-STAT3 signaling, we generated SOCS3 knockdown transgenic (TG) mice for development of an animal model of spondyloarthritis. Read More

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November 2018
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Association study of copy number variation in BMP8A gene with the risk of ankylosing spondylitis in Iranian population.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Copy number variation (CNV) of DNA segments has been considered as an important component of genetic variation, affecting the quality and quantity of gene expression. Bone morphogenic protein 8A (BMP8A) has been reported to function in bone formation. With respect to the bone and joint complications in ankylosing spondylitis (AS), this investigation aimed to study the role of BMP8A gene CNV in impressing the gene expression as well as the disease risk. Read More

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November 2018
1 Read
3.263 Impact Factor

Complications of spinal osteotomy for thoracolumbar kyphosis secondary to ankylosing spondylitis in 342 patients: incidence and risk factors.

Authors:

J Neurosurg Spine 2018 Oct 1:1-8. Epub 2018 Oct 1.

OBJECTIVETo describe the incidence of complications in spinal osteotomy for thoracolumbar kyphosis caused by ankylosing spondylitis (AS) and to investigate the risk factors for these complications.METHODSFrom April 2000 to July 2017, 342 consecutive AS patients with a mean age (± SD) of 35.4 ± 9. Read More

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October 2018

Characteristics of deformity surgery in patients with severe and rigid cervical kyphosis (CK): results of the CSRS-Europe multi-centre study project.

Eur Spine J 2018 Nov 27. Epub 2018 Nov 27.

, Stockholm, Sweden.

Introduction And Purpose: Little information exists on surgical characteristics, complications and outcomes with corrective surgery for rigid cervical kyphosis (CK). To collate the experience of international experts, the CSRS-Europe initiated an international multi-centre retrospective study.

Methods: Included were patients at all ages with rigid CK. Read More

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November 2018
1 Read

Impact of adalimumab on clinical outcomes, healthcare resource utilization, and sick leave in patients with ankylosing spondylitis: an observational study from five Central and Eastern European countries.

Drugs Context 2018 21;7:212556. Epub 2018 Nov 21.

Department of Rheumatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Background: Patients with ankylosing spondylitis (AS) are substantial users of healthcare resources due to chronic and potentially disabling disease. This study assessed the impact of adalimumab on clinical outcomes, healthcare resource utilization, and sick leave in patients with AS in five Central and Eastern Europe (CEE) countries.

Methods: This was an observational study in the routine clinical setting. Read More

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November 2018
2 Reads

Discrepancies Between FDA-Required Labeling and Evidence that Payers Cite in Drug Coverage Policies.

J Manag Care Spec Pharm 2018 Dec;24(12):1240-1246

1 The Center for the Evaluation of Value and Risk in Health, Tufts Medical Center, Boston, Massachusetts.

Background: FDA-required labeling summarizes certain data that the FDA relies on in its drug approval process. However, when determining coverage of specialty drugs, health care payers may consider dissimilar evidence.

Objective: To compare evidence cited by the largest U. Read More

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December 2018
3 Reads

Ankylosing spinal disease - diagnosis and treatment of spine fractures.

World Neurosurg 2018 Nov 23. Epub 2018 Nov 23.

Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.

Background: In patients with ankylosing spinal diseases (ASD) including ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH) even low-impact trauma can lead to complex injury. They seem to be highly unstable and associated with higher mortality rates when compared to the general spine trauma population.

Methods: We reviewed the charts of a consecutive series of 41(34 male, 7 female) patients with ASD and unstable traumatic spine injuries who were admitted to our department between 2007 and 2016. Read More

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November 2018
2 Reads

The Safety Profile of Tumor Necrosis Factor Inhibitors in Ankylosing Spondylitis: Are TNF Inhibitors Safer Than We Thought?

J Clin Pharmacol 2018 Nov 26. Epub 2018 Nov 26.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

Tumor necrosis factor (TNF) inhibitors significantly improved the treatment options for patients with ankylosing spondylitis. Unfortunately, currently, there is no strategy for sustaining remission of the disease with TNF inhibitors; after discontinuation, a high percentage of patients experience flares in a short time. Therefore, up-to-date, long-term use of TNF inhibitors in patients with ankylosing spondylitis remains necessary. Read More

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November 2018
1 Read

Assessment of immunological profile in ankylosing spondylitis patients following a clinical trial with guluronic acid (G2013), as a new NSAID with immunomodulatory properties.

Immunol Res 2018 Nov 24. Epub 2018 Nov 24.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Box 14155-6446, Tehran, Iran.

The present research aims to study the effects of guluronic acid (G2013) on gene expression levels of the T-bet, GATA3, RORγt, AHR, and FOXP3 transcription factors and on gene expression of their related cytokines following oral administration of this drug in ankylosing spondylitis (AS) patients. In this trial (clinical trial identifier: IRCT2016091813739N4), 14 AS patients and 12 age- and sex-matched healthy individuals were enrolled. The level of transcription factors' gene expression and expression of their related cytokines were measured by quantitative real-time PCR, before and 3 months after G2013 therapy. Read More

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November 2018
6 Reads
3.100 Impact Factor

Persistence with biological drugs in patients treated in rheumatology practices in Germany.

Rheumatol Int 2018 Nov 24. Epub 2018 Nov 24.

Epidemiology, IQVIA, Commercial GmbH & Co OHG, Unterschweinstiege 2-14, 60549, Frankfurt am Main, Germany.

The goal of this study was to investigate the persistence with biological drugs in patients treated in rheumatology practices in Germany. This study included patients diagnosed with rheumatoid arthritis (RA), psoriatic arthritis (PA), or ankylosing spondylitis (AS) who received a first prescription of biological drugs between 2008 and 2016 (index date) in 21 rheumatology practices in Germany (n = 4925; Disease Analyzer database). The main outcome measure was the rate of persistence within 5 years of the index date. Read More

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November 2018
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Budget impact analysis of secukinumab versus adalimumab in the treatment of ankylosing spondylitis.

J Med Econ 2018 Nov 26:1-14. Epub 2018 Nov 26.

d South Karelia Social and Health Care District (Eksote) , Lappeenranta , Finland.

Background Biologic treatments have enhanced the treatment outcomes of patients with active ankylosing spondylitis (AS). Until recently, TNF-alpha-inhibitors have been the only biologics approved for the treatment of active AS. The objective of this study was to assess the potential financial impact of the first non-TNF-alpha biologic secukinumab (fully human IL-17A-inhibitor) versus adalimumab (TNF-alpha-inhibitor) in the treatment of AS in Finland. Read More

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November 2018
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The role of C-reactive protein as a predictor of treatment response in patients with ankylosing spondylitis.

Semin Arthritis Rheum 2018 Nov 2. Epub 2018 Nov 2.

Pfizer Innovative Health, Global Medical Affairs Pfizer Inc, Collegeville, PA, United States.

Objectives: To determine whether C-reactive protein (CRP) level is predictive of response to tumor necrosis factor-α blocker treatment in patients with ankylosing spondylitis (AS) and whether there is an optimal CRP range for treatment initiation.

Methods: In this post hoc analysis, data on etanercept-treated patients with AS were pooled from four randomized trials. Week 12 responses (ASAS20, ASAS50, ASDAS-CRP < 1. Read More

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November 2018
4 Reads

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial.

Ann Rheum Dis 2018 Nov 24. Epub 2018 Nov 24.

Inflammation-Immunopathology-Biotherapy Department (i2B), AP-HP, Pitié-Salpêtrière Hospital, Paris, France

Objective: Regulatory T cells (Tregs) prevent autoimmunity and control inflammation. Consequently, any autoimmune or inflammatory disease reveals a Treg insufficiency. As low-dose interleukin-2 (ld-IL2) expands and activates Tregs, it has a broad therapeutic potential. Read More

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November 2018
5 Reads

Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis.

Arthritis Res Ther 2018 Nov 21;20(1):259. Epub 2018 Nov 21.

Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Minsheng Road, Dalin, Chiayi, 62247, Taiwan.

Background: Interleukin (IL)-23 can facilitate the differentiation of IL-17-producing helper T cells (Th17). The IL-23/IL-17 axis is known to play a key role in the immunopathogenesis of ankylosing spondylitis (AS). We hypothesized that the expression of microRNAs (miRNAs, miRs) would be regulated by IL-23 and that these miRNAs could participate in the immunopathogenesis of AS. Read More

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November 2018
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Novel Imaging Modalities in Detection of Cardiovascular Involvement in Ankylosing Spondylitis.

Scand Cardiovasc J 2018 Nov 21:1-24. Epub 2018 Nov 21.

e Cardiology Department , Tekirdag, State Hospital , Tekirdag , Turkey.

Objectives: The diagnosis of cardiovascular involvement in ankylosing spondylitis (AS) is usually delayed since conventional echocardiography relies mainly on the morphological alterations. The aim of this study was to evaluate the role of echocardiographic methods such as tissue Doppler and strain imaging of left ventricle (LV) and proximal aorta; and concentrations of biomarkers of cardiac fibrosis such as galectin-3 (Gal-3) and soluble suppression-of-tumorogenicity-2 (sST2) in determining early cardiovascular impairment in AS.

Design: In this prospective study of 75 AS and 30 healthy subjects (mean age 41. Read More

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November 2018
3 Reads