18,989 results match your criteria Ankylosing Spondylitis


Genomewide Association Study of Acute Anterior Uveitis Identifies New Susceptibility Loci.

Invest Ophthalmol Vis Sci 2020 Jun;61(6)

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Purpose: Acute anterior uveitis (AAU) is a common intraocular inflammatory disease. AAU occurs in 30% to 50% of patients with ankylosing spondylitis (AS), and both conditions are strongly associated with human leukocyte antigen (HLA)-B27, implying a shared etiology. This study aims to apply genomewide association study (GWAS) to characterize the genetic associations of AAU and their relationship to the genetics of AS. Read More

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http://dx.doi.org/10.1167/iovs.61.6.3DOI Listing

Cervical Flexion Osteotomy through One-Stage Posterior-Anterior-Posterior Approach for Cervical Extension Deformity in Ankylosing Spondylitis: A Novel Surgical Technique.

Orthop Surg 2020 Jun 3. Epub 2020 Jun 3.

Orthopedics Department, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

The present study was to introduce a new surgical technique of cervical flexionosteotomy, with an emphasis on the clinical and radiographic outcomes. Two male patients aged 45 and 21 years presented with cervical extension deformity in ankylosing spondylitis (AS). Both patients exhibited upward deviation of the forward gaze. Read More

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http://dx.doi.org/10.1111/os.12670DOI Listing

Ultra-widefield fundus fluorescein angiography findings in patients with ankylosing spondylitis experiencing uveitis.

Int Ophthalmol 2020 Jun 2. Epub 2020 Jun 2.

Department of Ophthalmology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey.

Aim: To evaluate ultra-widefield fundus fluorescein angiography (FFA) findings in cases of ankylosing spondylitis (AS)-associated uveitis.

Materials And Methods: Forty-five eyes of 23 AS patients followed up with a diagnosis of uveitis were included.

Results: Sixteen (69. Read More

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http://dx.doi.org/10.1007/s10792-020-01443-zDOI Listing

Rheumatologic Disorders and the Nervous System.

Continuum (Minneap Minn) 2020 Jun;26(3):591-610

Purpose: This article describes the neurologic manifestations of systemic autoimmune diseases.

Recent Findings: Systemic autoimmune diseases can be associated with a wide spectrum of neurologic comorbidities involving the central and peripheral nervous systems. Systemic lupus erythematosus (SLE) can be associated with a number of manifestations predominantly affecting the central nervous system (CNS), whereas peripheral neuropathy is less common. Read More

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http://dx.doi.org/10.1212/CON.0000000000000856DOI Listing

Non-Steroidal Anti-Inflammatory Drug Etoricoxib Facilitates the Application of Individualized Exercise Programs in Patients with Ankylosing Spondylitis.

Medicina (Kaunas) 2020 May 29;56(6). Epub 2020 May 29.

Department of Physical and Rehabilitation Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

The main objective of this study is to highlight the efficiency of different therapeutic means in patients with ankylosing spondylitis, resulting in the improvement of their quality of life. We conducted a randomized, longitudinal, controlled trial on 92 patients with ankylosing spondylitis over a period of 6 years. Disease activity was assessed using the BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) score. Read More

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http://dx.doi.org/10.3390/medicina56060270DOI Listing

Pityriasis Lichenoides Chronica in a Patient With Ankylosing Spondylitis Treated With Etanercept.

J Drugs Dermatol 2020 May;19(5):560-561

Background: Pityriasis lichenoides chronica, a papulosquamous disorder often considered a subtype of pityriasis lichenoides. It is considered a clonal T-cell disorder, which may be associated with cutaneous T-cell lymphoma that may develops in response to foreign antigens.

Case Presentation: We present a 38-year-old male patient with ankylosing spondylitis who was on treatment with etanercept. Read More

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Sarcoidosis with ankylosing spondylitis: changing therapeutic landscape.

Sarcoidosis Vasc Diffuse Lung Dis 2018 28;35(3):285-288. Epub 2018 Apr 28.

Metro Centre for Respiratory Diseases, Metro Multispecialty Hospital, Noida, UP, India.

Sarcoidosis is an inflammatory multisystem disease which rarely may coexist in patients with other autoimmune disease like ankylosing spondylitis (AS). The presence of such as association causes diagnostic and management dilemmas as sarcoidosis has been reported to develop in patients of AS treated with tumour necrosis factor alpha (TNF-α) inhibitors. We describe a 49-year-old male with ankylosing spondylitis and histologically proven sarcoidosis who was treated with infliximab and improved. Read More

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http://dx.doi.org/10.36141/svdld.v35i3.6679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170151PMC

Risk of incident autoimmune diseases in patients with thymectomy.

Ann Clin Transl Neurol 2020 Jun 1. Epub 2020 Jun 1.

Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Objectives: The data concerning the association between Tx and ADs remain unclear and are scarce. This study was undertaken to investigate whether people with Tx are more likely to develop ADs, compared to those without Tx.

Methods: Individuals who received Tx between 2002 and 2015 were identified and matched on age and sex with individuals without Tx. Read More

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http://dx.doi.org/10.1002/acn3.51055DOI Listing

Treatment Patterns and Health Care Resource Utilization Among Japanese Patients With Ankylosing Spondylitis: a Hospital Claims Database Analysis.

Mod Rheumatol 2020 May 31:1-23. Epub 2020 May 31.

Eli Lilly Japan K.K., Kobe, Japan.

To understand the current state of treatment patterns and health care resource utilization among patients in Japan with ankylosing spondylitis (AS) managed in the real-world setting. Patient records from the Medical Data Vision database were analyzed to identify patients with ICD-10 AS from April 2009 through July 2017. Measures evaluated included demographic, clinical, and other characteristics at diagnosis; treatment patterns; health care resource utilization; and costs. Read More

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http://dx.doi.org/10.1080/14397595.2020.1775927DOI Listing

Olfactory and Gustatory Dysfunction in a COVID-19 Patient with Ankylosing Spondylitis Treated with Etanercept: Case Report.

J Korean Med Sci 2020 Jun 1;35(21):e201. Epub 2020 Jun 1.

Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.

The neurologic manifestations concerning coronavirus disease 2019 (COVID-19) are highly penetrated. Anosmia and ageusia are one of the common acute neurologic symptoms, which develop in the early stage of COVID-19. However, it is not reported that how immunosuppressive agents affect these symptoms. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e201DOI Listing

Response to: 'Finding the right one' by Zanwar.

Ann Rheum Dis 2020 May 28. Epub 2020 May 28.

Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1136/annrheumdis-2020-217856DOI Listing

'Finding the right one'.

Ann Rheum Dis 2020 May 28. Epub 2020 May 28.

Department of Rheumatology, Ruby Hall Clinic, Pune, Maharashtra, India

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http://dx.doi.org/10.1136/annrheumdis-2020-217731DOI Listing

Forward flexed posture: reliability and determinants of tragus-to-wall measurement.

Physiother Theory Pract 2020 May 29:1-8. Epub 2020 May 29.

Physical Therapy, Campbell University College of Pharmacy and Health Sciences , Buies Creek, NC, USA.

Introduction: Forward flexed posture is an impairment in body structure commonly seen among older adults and those with pathologies such as ankylosing spondylitis and osteoporosis. Accurate measurement of forward flexed posture is important as it is related to pain, mobility limitations, and falls. Our purpose was to examine the reliability and determinants of forward flexed posture as indicated by tragus-to-wall (TTW) distance. Read More

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http://dx.doi.org/10.1080/09593985.2020.1771801DOI Listing

Traditional Chinese Eight Brocade Exercise Prescription for Ankylosing Spondylitis: A Quantitative Synthesis.

Complement Med Res 2020 May 28:1-5. Epub 2020 May 28.

Department of Traditional Chinese Medicine, Jiangyin Lingang Hospital, Jiangyin, China,

Introduction: The aim of this research was to assess the safety and effectiveness of traditional Chinese Eight Brocade exercise for ankylosing spondylitis (AS).

Methods: A literature search was conducted using twelve databases (Web of Science, EBSCO, AMED, SCOPUS, CINAHL, MEDLINE, EMBASE, DBPIA, KoreaMed Synapse, Oriental Medicine Advanced Searching Integrated System, Chinese Wan Fang, and China National Knowledge Infrastructure) from inception to June 2019. We only included randomized controlled trials (RCTs) regarding traditional Chinese Eight Brocade exercise for AS. Read More

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http://dx.doi.org/10.1159/000505312DOI Listing

Early detection of ankylosing spondylitis using texture features and statistical machine learning, and deep learning, with some patient age analysis.

Comput Med Imaging Graph 2020 Apr 26;82:101718. Epub 2020 Apr 26.

Department of Electrical and Computer Engineering, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada. Electronic address:

Ankylosing spondylitis (AS) is an arthritis with symptoms visible in medical imagery. This paper proposes, to the authors' best knowledge, the first use of statistical machine learning- and deep learning-based classifiers to detect erosion, an early AS symptom, via analysis of computed tomography (CT) imagery, giving some consideration to patient age in so doing. We used gray-level co-occurrence matrices and local binary patterns to generate input features to machine learning algorithms, specifically k-nearest neighbors (k-NN) and random forest. Read More

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http://dx.doi.org/10.1016/j.compmedimag.2020.101718DOI Listing

A Randomized, Double-Blind, Parallel-Group, Phase 1 Clinical Trial Comparing the Pharmacokinetic, Safety, and Immunogenicity of the Biosimilar HS016 and the Originator Adalimumab in Chinese Healthy Male Subjects.

Clin Pharmacol Drug Dev 2020 May 28. Epub 2020 May 28.

Phase I Clinical Trial Center, Huashan Hospital, Fudan University, Shanghai, China.

A comparison of the immunogenicity, safety, and pharmacokinetic properties of HS016 and its originator, adalimumab, was conducted in Chinese healthy male subjects. This was a phase 1 single-center, randomized, parallel-group double-blind clinical trial. Chinese healthy male subjects (1:1) allocated to HS016 and adalimumab groups were treated with single subcutaneous injections (40 mg/0. Read More

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http://dx.doi.org/10.1002/cpdd.816DOI Listing

Anti-tumour necrosis factor α therapy - Does it increase the risk of thyroid disease or protect against its development?

Pediatr Endocrinol Diabetes Metab 2020 May 28. Epub 2020 May 28.

Institute of Paediatrics, Department of Children and Youth Endocrinology, Jagiellonian University Me-dical College, Krakow, Poland.

Aim Of The Study: Tumour necrosis factor α (TNF-α) is a cytokine involved in the pathogenesis of many diseases, primarily those associated with auto-immunisation. Anti-TNF-α drugs are used in the therapy of many of them, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, psoriasis, or inflammatory bowel disease. TNF-α is also a key factor in the pathogenesis of autoimmune thyroid disease (AITD). Read More

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http://dx.doi.org/10.5114/pedm.2020.95618DOI Listing

Lower concentration of vitamin D is associated with lower DAS28 and VAS-pain scores in patients with inflammatory rheumatic diseases treated with infliximab: a pilot study.

Rheumatol Int 2020 May 27. Epub 2020 May 27.

Department of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Vinogradska 29, Zagreb, Croatia.

Vitamin D is beneficial in patients with immune-mediated rheumatic diseases as it has been shown that it lowers the incidence risk and the level of inflammation. To examine the association between clinical outcomes and initial 25-hydroxyvitamin D [25(OH)D] concentrations in patients with the immune-mediated rheumatic diseases treated with infliximab for 9 months. This study was performed in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) treated with infliximab for at least 38 weeks. Read More

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http://dx.doi.org/10.1007/s00296-020-04607-3DOI Listing

Home storage of biological medications administered to patients with rheumatic diseases.

Adv Rheumatol 2020 May 27;60(1):30. Epub 2020 May 27.

Edumed Educação em Saúde, Rua Bispo Dom José, 2495, Curitiba, Paraná, 80440-080, Brazil.

Background: The inadequate storage of biopharmaceuticals may result in an ineffective therapeutic response since poor conservation can lead to the emergence of protein aggregates and cause immunogenicity in patients, which can increase the risk of adverse events by inducing the production of anti-drug antibodies. This can also lead to significant economic losses for public health, given the high cost of these medicines. The aim of this study was to verify whether the home storage of biopharmaceuticals dispensed by the Unified Public System was in accordance with the manufacturers' specified standards and whether external variables interfered with the correct home storage. Read More

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http://dx.doi.org/10.1186/s42358-020-00131-xDOI Listing

Risk for development of inflammatory bowel disease under inhibition of interleukin 17: A systematic review and meta-analysis.

PLoS One 2020 27;15(5):e0233781. Epub 2020 May 27.

Division of Gastroenterology, Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.

Objective: Cases of inflammatory bowel disease (IBD) during treatment with interleukin (IL)-17 antagonists have been reported from trials in psoriasis, psoriatic arthritis, and ankylosing spondylitis. The aim of this study was to assess the overall risk for development of IBD due to IL-17 inhibition.

Design: Systematic review and meta-analysis of studies conducted 2010-2018 of treatment with IL-17 antagonists in patients with psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233781PLOS

Lessons learnt from delayed diagnosis of FGF-23-producing tumour-induced osteomalacia and post-operative hungry bone syndrome.

Authors:
S Kumar T Diamond

Bone Rep 2020 Jun 6;12:100276. Epub 2020 May 6.

St George Public Hospital, Kogarah, NSW 2217, Australia.

Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by a fibroblast growth-factor-23 (FGF-23)-secreting phosphaturic mesenchymal tumour (PMT) and is characterised by hypophosphataemic osteomalacia. We present a 36-year-old man initially presenting with diffuse bone and joint pain who was inappropriately treated for presumed ankylosing spondylitis for 2 years. Whole-body bone scan suggested metabolic bone disease, prompting referral to our endocrine institution. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235936PMC

Surgical Treatment for Severe Fixed Hyperkyphosis in an Adult Patient Suffering From Ankylosing Spondylitis and Hereditary Hypophosphatemia With Vertebral Osteopetrosis.

Clin Spine Surg 2020 May 22. Epub 2020 May 22.

Department of Orthopedics and Trauma-Surgery, Krankenhaus Nord-Klinik Floridsdorf, Vienna.

Purpose: Ankylosing spondylitis and hereditary hypophosphatemia with long-term high dose supplementation of phosphorous and calcitriol can both lead to severe structural abnormalities of the vertebrae. Impairment of spinal mobility and spinal deformity may ultimately necessitate surgical treatment. A severe fixed hyperkyphosis in a patient with ankylosing spondylitis is a surgically demanding condition, therefore, the indication for surgical treatment should be thoroughly considered and chosen individually. Read More

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http://dx.doi.org/10.1097/BSD.0000000000001011DOI Listing

Spondyloarthritis evolution: what is in your history?

Curr Opin Rheumatol 2020 Jul;32(4):321-329

Division of Rheumatology, Cedars-Sinai Medical Center, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.

Purpose Of Review: This review encompasses a detailed history of spondyloarthritis (SpA) evolution as early as the 17th century, continues on to the current concept of SpA, and ends with current gaps in our understandings of SpA.

Recent Findings: Until the early 1960s, ankylosing spondylitis and other SpA family members were considered to be variants of rheumatoid arthritis (RA). The formal medical community separated them from RA at that time, and shortly thereafter they were recognized to be inter-connected based on shared clinical, laboratory, and imaging features. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000712DOI Listing

Safety and efficacy of secukinumab treatment in a patient with ankylosing spondylitis and concomitant multiple sclerosis: a commentary.

Clin Exp Rheumatol 2020 May 20. Epub 2020 May 20.

Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

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Reply to: Safety and efficacy of secukinumab treatment in a patient with ankylosing spondylitis and concomitant multiple sclerosis: a commentary.

Clin Exp Rheumatol 2020 May 20. Epub 2020 May 20.

Dipartimento di Medicina di Precisione, Section of Rheumatology, Università della Campania L. Vanvitelli, Napoli, Italy.

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Gender bias in therapeutic effort: from research to health care.

Farm Hosp 2020 Apr 14;44(3):109-113. Epub 2020 Apr 14.

Clinical Pharmacology Unit and Instituto de Investigación Sanitaria y Biomédica de ISABIAL. Hospital General de Alicante, Alicante. Spain.

There are relevant dimensions from a gender perspective related to  therapeutic effort. To illustrate and discuss possible gender bias related  to medicines, through the consumption analysis in women, the  prescription of biological drugs according to sex, the potential gender  inequality in adverse drug reactions, and research with clinical trials, as  well as the decisions of international institutions in the marketing of  medicinal products. There is greater tendency to prescribe pain  relievers, regardless of pain, and drugs for low intensity depressive  symptoms in women than in men. Read More

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http://dx.doi.org/10.7399/fh.11394DOI Listing

Down-regulated miR-495 can target programmed cell death 10 in ankylosing spondylitis.

Mol Med 2020 May 25;26(1):50. Epub 2020 May 25.

School of Basic Medicine, Gannan Medical University, Ganzhou, 341000, Jiangxi, People's Republic of China.

Background: MicroRNAs (miRNAs) play crucial roles in regulating eukaryotic gene expression. Recent studies indicated that aberrantly expressed miRNAs are involved in the pathogenesis of ankylosing spondylitis (AS). Indeed, hsa-miR-495-3p (miR-495) has been reported as an anti-oncogene in different cancers. Read More

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http://dx.doi.org/10.1186/s10020-020-00157-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249445PMC

Microbes, helminths, and rheumatic diseases.

Best Pract Res Clin Rheumatol 2020 May 7:101528. Epub 2020 May 7.

Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHULN and Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Lisboa, Portugal.

There has been a progressive interest on modifications of the human defense system following insults occurring in the interface between our body and the external environment, as they may provoke or worsen disease states. Studies suggest that billions of germs, which compose the gut microbiota influence one's innate and adaptive immune responses at the intestinal level, but these microorganisms may also impact rheumatic diseases. The microbiota of the skin, respiratory, and urinary tracts may also be relevant in rheumatology. Read More

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http://dx.doi.org/10.1016/j.berh.2020.101528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203059PMC

Effects of dihydrotestosterone on osteoblast activity in curdlan-administered SKG mice and osteoprogenitor cells in patients with ankylosing spondylitis.

Arthritis Res Ther 2020 May 24;22(1):121. Epub 2020 May 24.

Hanyang University Institute for Rheumatology Research, Seoul, Republic of Korea.

Background: Ankylosing spondylitis (AS) is characteristically male-predominant, and progressive spinal ankylosis affects male patients more severely; however, the hormonal effects in males with AS are poorly understood.

Methods: In the present study, the regulatory effects of dutasteride, a 5-α reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone (DHT), were examined in curdlan-administered male SKG mice to determine spinal bone formation, bone metabolism-related markers, and interleukin (IL)-17A cytokine and T cell populations. In addition, the effects of DHT on primary osteoprogenitors from the facet joints of AS patients were assessed based on osteoblast-related parameters. Read More

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http://dx.doi.org/10.1186/s13075-020-02217-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245802PMC

A case of severe flare reaction observed in HLA B27 associated acute anterior uveitis.

BMC Ophthalmol 2020 May 24;20(1):201. Epub 2020 May 24.

Department of Ophthalmology, Dongguk University, Ilsan Hospital, 814, Siksadong, Ilsan-dong-gu, Goyang, Gyunggido, 410-773, South Korea.

Background: Anterior chamber flare reaction refers to the light reflection from the protein in aqueous humor. We report a case of very severe flare reaction observed in human leukocyte antigen (HLA)- B27 associated acute anterior uveitis (AAU).

Case Presentation: An age 43 male patient visited the uveitis clinic complaining of decreased visual acuity in the right eye which developed 1 week before. Read More

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http://dx.doi.org/10.1186/s12886-020-01472-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247201PMC

Paradoxical Skin Reaction to Certolizumab, an Overlap of Pyoderma Gangrenosum and Psoriasis in a Young Woman Treated for Ankylosing Spondylitis: Case Report with Literature Review.

Dermatol Ther (Heidelb) 2020 May 23. Epub 2020 May 23.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wrocław, Poland.

Introduction: Biologic agents form an indispensable part of modern therapeutic regimens for the treatment of severe inflammatory diseases, especially in the fields of rheumatology, dermatology and gastroenterology. They are favoured by both physicians and patients due to their high effectiveness, good patient tolerance and safety. However, interference in the regulation and dynamics of inflammatory cytokines can on occasion lead to an onset of a dermatological condition also known as paradoxical skin reaction. Read More

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http://dx.doi.org/10.1007/s13555-020-00398-4DOI Listing

Non-steroidal anti-inflammatory drugs in patients with stable ankylosing spondylitis receiving tumor necrosis factor inhibitor: continued vs withdrawn.

Clin Rheumatol 2020 May 23. Epub 2020 May 23.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Objective: To investigate the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on disease activity in patients with stable ankylosing spondylitis (AS) receiving tumor necrosis factor inhibitor (TNFi).

Methods: In this retrospective observational study, a total of 189 patients with stable AS receiving TNFi were included. Patients were classified into NSAID withdrawn group (n = 48) and NSAID continued group (n = 141), according to the use of NSAIDs. Read More

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http://dx.doi.org/10.1007/s10067-020-05157-6DOI Listing

Patients with ankylosing spondylitis treatment by golimumab: a systematic review and meta-analysis.

Eur Spine J 2020 May 23. Epub 2020 May 23.

Department of Spinal Surgery, General Hospital of Ningxia Medical University, Ningxia Medical University, 804 Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.

Purpose: The goal of this study was to review relevant randomized controlled trials in order to determine the clinical efficacy of golimumab in the treatment of ankylosing spondylitis (AS).

Methods: Using appropriate keywords, we identified relevant studies using PubMed, Cochrane and Embase. Key pertinent sources in the literature were also reviewed, and all articles published through November 2019 were considered for inclusion. Read More

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http://dx.doi.org/10.1007/s00586-020-06466-9DOI Listing

Predictive value of semi-quantitative index from F-18-fluoride PET/CT for treatment response in patients with ankylosing spondylitis.

Eur J Radiol 2020 May 12;129:109048. Epub 2020 May 12.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Hanyang UniversityMedical Center, 222-1 Wangsimni-ro, Seongdong-gu, Seoul, 04764, South Korea. Electronic address:

Purpose: We aimed to investigate whether the lesion-to-background ratio (LBR) of the whole spinal column in ankylosing spondylitis (AS) patients based on baseline F-18-fluoride positron emission tomography/computed tomography (PET/CT) is associated with treatment response.

Methods: Twenty-eight male patients with a wide range of disease activity were included in this study. Abnormal bone metabolic lesions on baseline F-18-fluoride PET/CT were visually assessed in three areas: anterior discovertebral units (DVUs) and posterior joints (cervical, thoracic, and lumbar facet joints, costovertebral joints, and costotransverse joints) of vertebrae and sacroiliac joints of the sacrum. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109048DOI Listing

Risk of Serious Infection Associated with Agents that Target T-Cell Activation and Interleukin-17 and Interleukin-23 Cytokines.

Authors:
Stanford Shoor

Infect Dis Clin North Am 2020 Jun;34(2):179-189

Stanford University, 1000 Welch Road Suite 203, Palo Alto, CA 94304, USA. Electronic address:

Co-stimulatory T-cell inhibitors are used in the treatment of rheumatoid arthritis and to prevent rejection of renal transplants. Inhibitors of the intereukin (IL-17) cytokine are indicated for psoriasis, psoriatic arthritis and ankylosing spondylitis and anti- IL-23 drugs for psoriasis. Serious infections occur in 4. Read More

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http://dx.doi.org/10.1016/j.idc.2020.02.001DOI Listing

Risks of solid cancers in elderly persons with osteoarthritis or ankylosing spondylitis.

Rheumatology (Oxford) 2020 May 23. Epub 2020 May 23.

National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.

Objectives: Patients with osteoarthritis and ankylosing spondylitis have lower cancer-related mortality than the general population. We examined risks of solid cancers at 16 sites in elderly patients with knee or hip osteoarthritis (KHOA) or ankylosing spondylitis.

Methods: In this population-based retrospective cohort study, we used US Medicare data from 1999 to 2010 to identify cohorts of persons with KHOA or ankylosing spondylitis, and a general population group without either condition, who were followed through 2015. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa166DOI Listing

Impact of Persistence with Tumor Necrosis Factor Inhibitors on Healthcare Resource Utilization and Costs in Chronic Inflammatory Joint Diseases.

Br J Clin Pharmacol 2020 May 22. Epub 2020 May 22.

Sorbonne Université, GRC 08, Institut Pierre Louis d'Epidémiologie et Santé Publique, AP-HP, Service de rhumatologie, Hôpital Pitié-Salpêtrière, F 75013, Paris, France.

Aim: To assess persistence with subcutaneous (SC) Tumor Necrosis Factor (TNF) inhibitors as well as the impact of persistence on healthcare resource utilization (HCRU) and costs in patients with chronic inflammatory joint diseases.

Methods: In this cohort study using population-based French claims data (from 2011 to 2014), we measured persistence with SC TNF inhibitors within 12 months (M0-12) following treatment initiation in treatment-naïve and treatment-experienced users (divided into 3 cohorts: rheumatoid arthritis [RA], ankylosing spondylitis [AS], and psoriatic arthritis [PsA]). Persistent patients were propensity score matched to non-persistent patients at M12. Read More

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http://dx.doi.org/10.1111/bcp.14387DOI Listing

Robot-Assisted Total Hip Arthroplasty for Arthrodesed Hips.

Ther Clin Risk Manag 2020 4;16:357-368. Epub 2020 May 4.

Department of Orthopedics, Chinese PLA General Hospital, Beijing, People's Republic of China.

Background: Conversion of arthrodesed hips to total hip arthroplasty (THA) remains technically demanding. This study aims to evaluate the safety and efficacy of robot-assisted THA in arthrodesed hips.

Methods: We retrospectively analyzed 45 ankylosing spondylitis patients with hip arthrodesis in the Chinese PLA General Hospital between August 2018 and August 2019. Read More

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http://dx.doi.org/10.2147/TCRM.S246565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213954PMC

Association of body mass index on disease activity in axial spondyloarthritis: systematic review and meta-analysis.

RMD Open 2020 May;6(1)

Division of Rheumatology, University of California San Francisco, San Francisco, California, USA.

Objectives: In axial spondyloarthritis (axSpA), higher body mass index (BMI) is associated with worse outcomes including response to biologics. Further clarity is needed on whether BMI is associated with disease activity overall, independent of treatment response. We performed a systematic review and meta-analysis to assess the association between BMI and disease activity as reported by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) or Ankylosing Spondylitis Disease Activity Score (ASDAS) in axSpA. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001225DOI Listing

Evaluation of changes in choroidal vascularity during acute anterior uveitis attack in patients with ankylosing spondylitis by using binarization of EDI-optical coherence tomography images.

Photodiagnosis Photodyn Ther 2020 May 17:101778. Epub 2020 May 17.

Department of Ophthalmology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.

Background: To evaluate the effect of the first acute anterior uveitis (AAU) attack on the choroid by using an image binarization tool on images from enhanced depth imaging (EDI)-optical coherence tomography (OCT) scans in patients with ankylosing spondylitis (AS).

Methods: In this study, three groups were formed: uveitic eyes (UE; n = 20) of patients with AS, the non-uveitic eyes (NUE; n = 20) of these patients, and the eyes of healthy controls (n = 20). EDI-OCT images were obtained during the first AAU attack and at three months after treatment in patients with AS. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101778DOI Listing

A Panoply of Rheumatological Manifestations in Patients with GATA2 Deficiency.

Sci Rep 2020 May 20;10(1):8305. Epub 2020 May 20.

Office of the Clinical Director, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Purpose: To characterize rheumatological manifestations of GATA2 deficiency.

Methods: Single-center, retrospective review of 157 patients with GATA2 deficiency. Disease course, laboratory results, and imaging findings were extracted. Read More

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http://dx.doi.org/10.1038/s41598-020-64852-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239896PMC
May 2020
5.078 Impact Factor

Back pain, ankylosing spondylitis and social media usage; a descriptive analysis of current activity.

Rheumatol Int 2020 May 19. Epub 2020 May 19.

Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Royal United Hospital Bath NHS Foundation Trust, Combe Park, Bath, BA1 3NG, UK.

Social media usage by back pain patients is a new and developing area. Analysing patterns of this online activity offers a new way to understand our patients' concerns and behaviour around disease. Large volume data can be evaluated on a scale not feasible through alternative methods. Read More

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http://dx.doi.org/10.1007/s00296-020-04600-wDOI Listing

Sex hormone-binding globulin and arthritis: a Mendelian randomization study.

Arthritis Res Ther 2020 May 18;22(1):118. Epub 2020 May 18.

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, 310009, Hangzhou, China.

Background: Sex hormone-binding globulin (SHBG) has been reported to be a risk factor associated with the development of arthritis by previous observational studies more so of three common forms of arthritis: osteoarthritis (OA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). This study aimed to determine whether the concentrations of circulating SHBG are causally associated with the risk of OA, RA, and AS.

Methods: The two-sample Mendelian randomization (MR) approach was used for this study. Read More

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http://dx.doi.org/10.1186/s13075-020-02202-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236473PMC

Association Between Tumor Necrosis Factor Inhibitor Exposure and Inflammatory Central Nervous System Events.

JAMA Neurol 2020 May 18. Epub 2020 May 18.

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Importance: Tumor necrosis factor (TNF) inhibitors are common therapies for certain autoimmune diseases, such as rheumatoid arthritis. An association between TNF inhibitor exposure and inflammatory central nervous system (CNS) events has been postulated but is poorly understood.

Objective: To evaluate whether TNF inhibitor exposure is associated with inflammatory demyelinating and nondemyelinating CNS events in patients with an indication for TNF inhibitor use and to describe the spectrum of those CNS events. Read More

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http://dx.doi.org/10.1001/jamaneurol.2020.1162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235930PMC

Effect of TNF-inhibitor therapy on spinal structural progression in ankylosing spondylitis patients: A systematic review and meta-analysis.

Int J Rheum Dis 2020 May 17. Epub 2020 May 17.

Division of Rheumatology, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

To review the effect of tumor necrosis factor-alpha inhibitor (TNFi) therapies on radiographic progression in ankylosing spondylitis (AS) patients as evaluated by the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Pubmed, MEDLINE, EMBASE, and the Cochrane Library databases were searched from inception to August 2019. All comparative and non-comparative studies that evaluated the clinical effectiveness of TNFi on radiographic progression as assessed by mSASSS change at a minimum follow-up of 1 year were included. Read More

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http://dx.doi.org/10.1111/1756-185X.13829DOI Listing

Revision Total Hip Arthroplasty in Patients With Ankylosing Spondylitis: Long-Term Results.

J Arthroplasty 2020 Apr 27. Epub 2020 Apr 27.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Ankylosing spondylitis (AS) is a common inflammatory spondyloarthropathy with hip involvement in 40% of patients. With the recent interest in the hip-spine interplay, the purpose of this study was to define the long-term outcomes of revision total hip arthroplasty (THA) in the setting of AS.

Methods: 174 hips in patients with AS treated with revision THA from 1969 to 2016 were identified. Read More

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http://dx.doi.org/10.1016/j.arth.2020.04.071DOI Listing