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Clin Respir J 2020 May 27. Epub 2020 May 27.

Ankara University, Faculty of Medicine, Department of Chest Diseases, Ankara, Turkey.

Introduction: Home noninvasive mechanical ventilation (HNIV) in patients with chronic hypercapnic respiratory failure (CHRF) may improve the health related quality of life (HRQL) and reduce hospitalizations.

Objective: To determine the effects of HNIV on HRQL, sleep quality and hospitalization rates in restrictive thoracic diseases (RTD) and COPD patients with CHRF.

Methods: In this prospective, single center study patients divided into two groups; the COPD and the RTD groups. Read More

Dent Traumatol 2020 May 27. Epub 2020 May 27.

Faculty of Medicine and Dentistry, University of Alberta, Alberta, Canada.

Avulsion of permanent teeth is one of the most serious dental injuries. Prompt and correct emergency management is essential for attaining the best outcome after this injury. The International Association of Dental Traumatology (IADT) has developed these Guidelines as a consensus statement after a comprehensive review of the dental literature and working group discussions. Read More

Eur J Obstet Gynecol Reprod Biol 2020 May 13;250:195-202. Epub 2020 May 13.

Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey.

Objective: To share our experience in diagnosis of congenital central nervous system (CNS) abnormalities by fetal magnetic resonance imaging (MRI).

Study Design: This study consisted of 110 pregnancies. Neurosonography (NS) findings were compared with MRI results. Read More

Gait Posture 2020 May 16;79:251-255. Epub 2020 May 16.

Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Samanpazarı, Ankara, 06100, Turkey.

Background: It is known that the patients with chronic low back pain (CLBP) has different spatiotemporal characteristics than healthy controls such as average speed, cadence, step and stride length parameters. CLBP is a heterogeneous phenomenon in terms of causing various level of disability.

Research Question: Does disability levels make a difference on spatiotemporal characteristics of patients with CLBP?

Methods: 66 patients with CLBP and 32 healthy controls between the ages of 25 and 65 years participated to study. Read More

Plast Reconstr Surg 2020 Jun;145(6):1073e-1088e

Seattle, Wash.; Birmingham, United Kingdom; Lisbon, Portugal; and Ankara, Turkey From the Division of Plastic Surgery, University of Washington; the Craniofacial Center, Seattle Children's Hospital; the Craniofacial Unit, Birmingham Children's Hospital; the Facial Reconstructive Unit, Hospital da Luz; and the Department of Plastic, Reconstructive and Aesthetic Surgery, Hacettepe University Faculty of Medicine.

Learning Objectives: After studying this article and viewing the video, the participant should be able to: 1. Compare the relative stability and neurosensory changes following mandible distraction osteogenesis with those after traditional advancement and fixation. 2. Read More

J Glaucoma 2020 May 26. Epub 2020 May 26.

Gazi University School of Medicine, Department of Ophthalmology, Ankara, TURKEY.

PRéCIS:: The present study demonstrates that the surgical success rate of circumferential trabeculotomy is 64.7% according to target IOP ≤21▒mmHg and 30% ≥reduction from baseline in patients with neonatal-onset primary congenital glaucoma, with an average follow-up of 35.1 months. Read More

Wound Manag Prev 2020 Jan;66(1):30-38

Koç University, Faculty of Nursing, Istanbul, Turkey.

The creation of a stoma is a life-saving surgical procedure that requires major adjustments.

Purpose: The aim of this study was to examine the relationships among family functioning, perceived social support, and adaptation to living with a stoma.

Method: A descriptive, cross-sectional survey was conducted between October 2013 and June 2015 among consecutive patients who visited the stomatherapy unit of a university hospital in Ankara, Turkey, for regular follow-up visits. Read More

Ocul Immunol Inflamm 2020 May 27:1-7. Epub 2020 May 27.

Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.

: To report a case of choroidal neovascularization (CNV), which was not obvious with dye angiography but was detected with optical coherence tomography angiography (OCTA).: A 50-year-old female presented with decreased vision in her right eye. Funduscopic examination revealed a swollen hyperemic disc, peripapillary exudation, and choroidal infiltration. Read More

Soft Matter 2020 May 27. Epub 2020 May 27.

Department of Physics, University of Gothenburg, SE-41296 Gothenburg, Sweden. and Soft Matter Lab, Department of Physics and UNAM - National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.

Correction for 'Controlling the dynamics of colloidal particles by critical Casimir forces' by Alessandro Magazzù et al., Soft Matter, 2019, 15, 2152-2162, DOI: 10.1039/C8SM01376D. Read More

Dent Traumatol 2020 May 27. Epub 2020 May 27.

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

Traumatic injuries to the primary dentition present special problems that often require far different management when compared to that used for the permanent dentition. The International Association of Dental Traumatology (IADT) has developed these Guidelines as a consensus statement after a comprehensive review of the dental literature and working group discussions. Experienced researchers and clinicians from various specialties and the general dentistry community were included in the working group. Read More

J Sci Food Agric 2020 May 26. Epub 2020 May 26.

Department of Food Engineering, Faculty of Engineering, Hacettepe University, Beytepe Campus, 06800, Ankara, Turkey.

Background: Heat treatment is the most common practice for the microbiological safety of milk; hence determination of the heat-treatment of milk is essential. Also, mislabeling or adulteration of expensive milk samples like ewe or goat milk with cow's milk is a growing problem in the dairy market. Thus, the determination of the authenticity of milk samples has crucial importance for both producers and consumers. Read More

Clin Rheumatol 2020 May 26. Epub 2020 May 26.

Faculty of Medicine Rheumatology Department, Gazi University, Ankara, Turkey.

Background: There has been a substantial improvement in classifying patients with primary Sjögren's syndrome (pSS), with the new 2016 ACR/EULAR classification criteria. It was aimed to investigate the potential role of parotid elastography in the classification of patients with pSS, as well as the clinical diagnosis of those who do not otherwise fulfil the criteria.

Method: This is a cross-sectional analysis of patients with pSS followed up in tertiary out-patient rheumatology clinic. Read More

Tech Coloproctol 2020 May 26. Epub 2020 May 26.

Department of Colon & Rectum Surgery, University of Health Science, Ankara Bilkent City Hospital, General Surgery, Çankaya, 06800, Ankara, Turkey.

Eur Arch Otorhinolaryngol 2020 May 26. Epub 2020 May 26.

Faculty of Dentistry, Department of Oral and Dentomaxillofacial Radiology, Gazi University, Ankara, Turkey.

Purpose: This study sought to assess the relationships between a morphological characteristic of the superior semicircular canal (SSC) and both the roof thickness of the glenoid fossa (GF) and bone changes of the temporomandibular joint (TMJ) on three-dimensional images.

Methods: Cone-beam computed tomography (CBCT) images of 200 individuals (105 females and 95 males; 400 temporal bone regions) were examined by two different observers. The correlations between the bone thickness overlying the SSC and the thickness of the roof of the GF with TMJ's bone pathologies were analyzed. Read More

Aesthetic Plast Surg 2020 May 26. Epub 2020 May 26.

Department of Statistics, Faculty of Science, Hacettepe University, Cankaya, Ankara, 06800, Turkey.

Background: Rhinoplasty is one of the most unforgiving operations in facial plastic surgery. The correction of nasal deviation in an asymmetrical face can be challenging because known facial landmarks may mislead the surgeon. Eyebrows trimmed asymmetrically in an effort to create a more symmetrical facial appearance may be overlooked by surgeons. Read More

Front Physiol 2020 7;11:434. Epub 2020 May 7.

Molecular Entomology Lab., Department of Plant Protection Ankara, Faculty of Agriculture, Ankara University, Ankara, Turkey.

Lipids are the primary storage molecules and an essential source of energy in insects during reproduction, prolonged periods of flight, starvation, and diapause. The coordination center for insect lipid metabolism is the fat body, which is analogous to the vertebrate adipose tissue and liver. The fat body is primarily composed of adipocytes, which accumulate triacylglycerols in intracellular lipid droplets. Read More

Heart Lung 2020 May 23. Epub 2020 May 23.

Gazi University Faculty of Medicine, Department of Cardiology, Ankara, Turkey.

Background: Pulmonary and extrapulmonary impairments are prevalent in pulmonary arterial hypertension (PAH) which is a rare, chronic and progressive disease.

Objectives: To investigate the effects of upper extremity aerobic exercise training on exercise capacity, oxygen consumption, dyspnea and quality of life in patients with PAH.

Methods: In a prospective, randomized controlled, double-blinded study, eleven patients in training group applied upper extremity aerobic exercise training (50-80% of maximal heart rate), 15-45 min/day, 3 days a week for 6 weeks and 11 patients in control group alternating active upper extremity exercises for the same period. Read More

Talanta 2020 Aug 24;216:120960. Epub 2020 Mar 24.

Istanbul University-Cerrahpasa, Engineering Faculty, Chemistry Department, Avcilar, 34320, Istanbul, Turkey; Turkish Academy of Sciences (TUBA), Piyade Sokak No: 27, Cankaya, 06690, Ankara, Turkey.

A novel ferricyanide/Prussian blue (PB) assay for total antioxidant capacity (TAC) determination was developed exploiting the formation of PB nanoparticles in the presence of polyvinylpyrrolidone (PVP) as stabilizer. This improved method, named as "nanoparticle-based ferricyanide/Prussian blue assay (PBNP)", was applied to the TAC measurement of Cynara Scolymus L. (globe artichoke). Read More

Orphanet J Rare Dis 2020 May 26;15(1):126. Epub 2020 May 26.

Division of Child Neurology and Metabolic Disorders, University Children's Hospital, Heidelberg, Germany.

Background: Tetrahydrobiopterin (BH) deficiencies comprise a group of six rare neurometabolic disorders characterized by insufficient synthesis of the monoamine neurotransmitters dopamine and serotonin due to a disturbance of BH biosynthesis or recycling. Hyperphenylalaninemia (HPA) is the first diagnostic hallmark for most BH deficiencies, apart from autosomal dominant guanosine triphosphate cyclohydrolase I deficiency and sepiapterin reductase deficiency. Early supplementation of neurotransmitter precursors and where appropriate, treatment of HPA results in significant improvement of motor and cognitive function. Read More

Clin Nurs Res 2020 May 26:1054773820917299. Epub 2020 May 26.

Nursing Department, Faculty of Health Science, Gazi University, Ankara, Turkey.

This study aimed to investigate the effect of a discharge training program structured according to the Roy adaptation model (RAM) on patient outcomes (quality of life, coping-adaptation, self-esteem) following gynecologic oncology surgery. This nonrandomized intervention studies consisted of two stages. In the first stage, patients were interviewed, patient needs after discharges were determined. Read More

Plants (Basel) 2020 May 22;9(5). Epub 2020 May 22.

Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago 8330507, Chile.

Background: L. (Solanaceae) generally known as henbane, is commonly distributed in Europe and Asia. In Turkey, henbane seeds have been used in folk medicine to remove worms from the eyes. Read More

Sensors (Basel) 2020 May 21;20(10). Epub 2020 May 21.

Deptartment of Electrical and Electronics Engineering, Hacettepe University, Ankara 06800, Turkey.

This study presents the design and fabrication of a flexible tactile sensor printed on a cellulose paper substrate using a carbon black (CB) - filled polyvinyl alcohol (PVA) polymer matrix as ink material. In the design, electrodes are obtained by screen printing of CB/PVA composite on dielectric cellulose paper. The screen-printing method is preferred for fabrication because of its simplicity and low manufacturing cost. Read More

Turk J Pharm Sci 2019 Mar 31;16(1):96-100. Epub 2018 Dec 31.

Ankara University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey.

Objectives: A negative association between Y:X sperm ratio and high levels of boron exposure was suggested in an epidemiological study conducted in boron mining areas of China. That study, however, was criticized by many authors due to some weaknesses in the study design. The present epidemiological study was designed to corroborate or refute the above-mentioned negative association between boron exposure and Y:X sperm ratio in men. Read More

Turk J Pharm Sci 2019 Mar 31;16(1):69-75. Epub 2018 Dec 31.

Atatürk University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Ankara, Turkey.

Objectives: To determine the chemical composition and antimicrobial activity of the essential oils of the aerial parts of L., roots of Peşmen and Quézel, and aerial parts of Petrov.

Materials And Methods: Essential oils were analyzed by gas chromatography and gas chromatography/mass spectrometry. Read More

Turk J Pharm Sci 2019 Mar 31;16(1):32-36. Epub 2018 Dec 31.

Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey.

Objectives: This study describes the qualitative and quantitative analysis of galantamine in species growing in Turkey.

Materials And Methods: Galantamine was isolated from bulbs and the structure of the compound elucidated by spectroscopic methods. The qualitative and quantitative analysis of galantamine was investigated in subsp. Read More

Turk J Pharm Sci 2019 Mar 31;16(1):1-7. Epub 2018 Dec 31.

Ankara University, Faculty of Pharmacy, Department of Biochemistry, Ankara, Turkey.

Objectives: To synthesize and characterize 2-[[6-(4-bromophenyl)imidazo[2,1-]thiazol-3-yl]acetyl]--alkyl/arylhydrazinecarbothioamide and 3-alkyl/aryl-2-[((6-(4-bromophenyl)imidazo[2,1-]thiazol-3-yl)acetyl)hydrazono]-5-nonsubstituted/methyl-4-thiazolidinone derivatives and evaluate them for their aldose reductase (AR) inhibitory effect.

Materials And Methods: 2-[[6-(4-bromophenyl)imidazo[2,1-]thiazol-3-yl]acetyl]--alkyl/arylhydrazinecarbothioamides () and 3-alkyl/aryl-2-[((6-(4-bromophenyl)imidazo[2,1-]thiazol-3-yl)acetyl)hydrazono]-5-nonsubstituted/methyl-4-thiazolidinones () were synthesized from 2-[6-(4-bromophenyl)imidazo[2,1-]thiazole-3-yl]acetohydrazide (). Their structures were elucidated by elemental analyses and spectroscopic data. Read More

Turk J Pharm Sci 2018 Dec 20;15(3):382-385. Epub 2018 Nov 20.

University of Karachi, International Center for Chemical and Biological Sciences, Karachi, Pakistan.

Objectives: The aim of this study was to investigate the probable toxicity on brine shrimp, phytotoxicity, and insecticidal activity of Aytac & Anderb.

Materials And Methods: The MeOH (80%) extract obtained from the whole plant of was fractionated through subsequent solvent extractions in increasing polarity with -hexane, chloroform, and -butanol. The MeOH (80%) extract and all fractions of were evaluated for their biologic activities using screening bioassays such as brine shrimp lethality test and phytotoxicity against , as well as insecticidal activity against and . Read More

Turk J Pharm Sci 2018 Dec 20;15(3):370-375. Epub 2018 Nov 20.

Ankara University, Department of Pharmacognosy, Ankara, Turkey.

Objectives: The aim of this study was to prepare pharmaceutical formulations of mouthwashes and to examine the antimicrobial activities of essential oils obtained from plants used traditionally in Turkey for oral infections.

Materials And Methods: Essential oils were obtained from herbal drugs using water distillation with Clevenger apparatus. The antimicrobial capacities of mouthwash formulations containing a mixture of essential oils with proportions of 4. Read More

Turk J Pharm Sci 2018 Dec 20;15(3):364-369. Epub 2018 Nov 20.

Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey.

Objectives: Pendimethalin and trifluralin are commonly used in many countries to control broadleaf weeds and grassy weed species because of their inhibitor effects on growth and cell division. In this study, we examined the apoptotic and anti-apoptotic potentials of pendimethalin and trifluralin on A549 human non-small lung cancer cells with several concentrations .

Materials And Methods: The expression levels of apoptosis-related genes , and were examined using quantitative RT-PCR after 24 h treatment of 1, 10, 50, 100 and 500 μM pendimethalin and trifluralin. Read More

Turk J Pharm Sci 2018 Dec 20;15(3):328-332. Epub 2018 Nov 20.

Başkent University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey.

Objectives: The aim of this study was to investigate the effect of SUM on IR-induced injury in rat heart and its effect on IPC-induced protection.

Materials And Methods: The rats were randomly divided into four groups: IR, SUM-IR, IPC, and SUM-IPC. The mean arterial blood pressure and heart rate were recorded to calculate PRP. Read More

Turk J Pharm Sci 2018 Dec 20;15(3):291-297. Epub 2018 Nov 20.

Cardiff University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Cardiff, United Kingdom.

Objectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of biologic activities such as antibacterial and antifungal. In this study antimicrobial activities of some indole derivatives mainly substituted with 1,2,4-triazole, 1,3,4-thiadiazole and hydrazinecarbothioamide were investigated to evaluate their efficacy. Read More

Turk J Pharm Sci 2018 Dec 20;15(3):271-277. Epub 2018 Nov 20.

Gazi University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Turkey.

Objectives: In the present study, an accurate, precise and simple method has been developed for the determination of TMZ in its pharmaceutical form by using HPLC.

Materials And Methods: An HPLC method with a DAD was validated according to ICH guidelines. A C18 column (150x4. Read More

Turk J Pharm Sci 2018 Dec 20;15(3):231-237. Epub 2018 Nov 20.

Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey.

Objectives: To determine the secondary metabolites from Lam. and evaluate their antimicrobial activity.

Materials And Methods: Antimicrobial activities of the isolated metabolites were determined using broth microdilutions against the bacteria ( ATCC 25922, ATCC 29212, ATCC 27853, ATCC 29213) and fungi ( ATCC 90028, ATCC 6258, ATCC 90018). Read More

Turk J Pharm Sci 2018 Aug 17;15(2):212-218. Epub 2018 Jul 17.

Hacettepe University, Faculty of Pharmacy, Department of Clinical Pharmacy, Ankara, Turkey.

Objectives: Committed legal regulations in primary healthcare services have resulted in certain issues and requirements about community pharmacy practices in Turkey. A professional collaboration between general practitioners and pharmacists is essential for the continuity of care in primary care settings. Therefore, the aim of this was study to explore community pharmacists' opinions on collaborative care along with new primary care regulations. Read More

Turk J Pharm Sci 2018 Aug 17;15(2):200-206. Epub 2018 Jul 17.

Ankara University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey.

Objectives: Genetic polymorphisms may help for individualized drug dosing and improved therapeutics. CYP3A4 is responsible for the metabolism of more than 50% of the commonly used drugs and metabolizes typical antipsychotic medications and antidepressant drugs. The objective of the study was to assess the genotype and allele frequencies of in Turkish patients with major depressive disorder receiving any SSRIs and to compare these results with the frequencies of other ethnic groups. Read More

Turk J Pharm Sci 2018 Aug 17;15(2):166-170. Epub 2018 Jul 17.

Hacettepe Unversity, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey.

Objectives: Diabetes, a heteregenous metabolic and chronic disease, is a growing health problem in most countries. It has been claimed that diabetes is associated with the increased formation of free radicals and decreased in antioxidant potential. Oxidative stress formed in diabetes may cause DNA damage in the tissues. Read More

Turk J Pharm Sci 2018 Aug 17;15(2):125-129. Epub 2018 Jul 17.

Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Ankara, Turkey.

Objectives: In this study, the antioxidant capacity, antimicrobial activity and phenolic contents of aerial parts and roots extracts of three endemic L. (Leguminosae) species ( Bornm., Hub. Read More

Turk J Pharm Sci 2018 Apr 2;15(1):97-102. Epub 2018 Apr 2.

Ankara University, Faculty of Science, Department of Biology, Ankara, Turkey.

Objectives: The aim of the study was to investigate the effects of methanol extracts from the flowers and leaves of and on the activity of AR, CAT, GST, and GPx.

Materials And Methods: Total phenolic and flavonoid contents of the plant samples were evaluated using Folin-Ciocalteu reagent and aluminum chloride colorimetric methods. Also, the effects of extracts on CAT, GST, GPx, and AR enzyme activities were investigated using kinetic assays. Read More

Turk J Pharm Sci 2018 Apr 2;15(1):44-49. Epub 2018 Apr 2.

Gazi University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Turkey.

Objectives: To describe a method for the determination of urea in blood serum using urease enzyme and 3-MPA-capped CdTe quantum dots.

Materials And Methods: The method is based on the increase in pH of the solution as a result of the reaction between urea and urease, which causes an increase in the phosphorescence signal of MPA-CdTe quantum dots in the pH range of 2.5-5. Read More

Turk J Pharm Sci 2017 Dec 20;14(3):324-334. Epub 2017 Nov 20.

Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey.

Gynecologic cancers are among the most common cancers in humans and animals. Treatment success depends on several factors including stage at diagnosis, tumor type, origin and metastasis. Currently, surgery, chemotherapy, and radiotherapy are preferred in the treatment of these cancers. Read More

Turk J Pharm Sci 2017 Dec 20;14(3):319-323. Epub 2017 Nov 20.

Ankara University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey.

Lung cancer is an increasing worldwide public health problem. Most patients with lung cancer have non-small cell lung cancer (NSCLC). These patients are mainly treated with standard platinum-based chemotherapy. Read More

Turk J Pharm Sci 2017 Dec 20;14(3):311-318. Epub 2017 Nov 20.

Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey.

It is well known that free oxygen radicals play an important role in the pathogenesis of several chronic disorders. Antioxidants are known as potential scavengers of reactive oxygen species that can protect biologic membranes against oxidative damage. Recent interest in phytochemicals has increased because of their protective effects against free oxygen radicals. Read More

Turk J Pharm Sci 2017 Dec 20;14(3):290-293. Epub 2017 Nov 20.

University of Karachi, International Center for Chemical and Biological Sciences, Karachi, Pakistan.

Objectives: To investigate the cytotoxic, phytotoxic, and insecticidal activity of (DC.) Boiss.

Materials And Methods: The crude methanol (80%) extract of the aerial parts of was fractionated to obtain -hexane, chloroform, -butanol, and remaining water fractions. Read More

Turk J Pharm Sci 2017 Dec 20;14(3):285-289. Epub 2017 Nov 20.

Ankara University, Faculty of Pharmacy, Department of Pharmacology, Ankara, Turkey.

Objectives: In this study, some novel 2-(2-phenyl)-1-benzo[d]imidazol-1-yl)-N'-(arylmethylene) acetohydrazide derivatives (1-12) were designed and synthesized.

Materials And Methods: Compounds 1-12 were obtained by condensing 2-(2-phenyl)-1-benzo[d]imidazol-1-yl)acetohydrazide (III) with the corresponding aromatic aldehyde derivatives in the presence of catalytic amounts of hydrochloric acid in ethanol.

Results: Following the structure elucidation, epidermal growth factor receptor kinase inhibitor activity was measured. Read More

Turk J Pharm Sci 2017 Dec 20;14(3):264-273. Epub 2017 Nov 20.

Ankara University, Faculty of Pharmacy, Department of Pharmacy Management, Ankara, Turkey.

Objectives: Countries' national drug policies include all key stakeholders (pharmacists, physicians, pharmaceutical firms, and patients) in the public, the private sector, and the field of pharmacy. The aim of this study was to outline pharmaceutical patents and data protection, orphan drugs, drug pricing, and surplus goods regarding pharmacoeconomics, promotions, inspections in the pharmaceutical industry, and policies in pharmacies with respect to buying and selling drugs, and to discuss ethics in particular.

Materials And Methods: Written laws in force relating to drugs in Turkey constitute the materials of this study. Read More

Turk J Pharm Sci 2017 Dec 20;14(3):257-263. Epub 2017 Nov 20.

Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey.

Objectives: Pycnogenol (PYC), a standardized extract from the bark of , consists of different phenolic compounds. PYC has shown to have protective effects on chronic diseases such as diabetes, asthma, cancer, and immune disorders. The aim of this study was to determine the effects of PYC against the DNA damage and biochemical changes in blood, liver, and lung tissues of ischemia-reperfusion (IR)-induced Wistar albino rats. Read More

Turk J Pharm Sci 2017 Dec 20;14(3):237-242. Epub 2017 Nov 20.

Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey.

Objectives: The deletion polymorphisms of glutathione S-transferase (GST) and genes result in the absence of the corresponding protein, which decreases the detoxification of carcinogens. Studies evaluating polymorphisms and protein expressions in the same patients are limited. Therefore, in this study, we aimed to investigate the association between polymorphisms and protein expressions of and in lung tissues of patients with non-small cell lung cancer (NSCLC). Read More

Turk J Pharm Sci 2017 Aug 15;14(2):207-212. Epub 2017 Aug 15.

Ankara University, Faculty Of Pharmacy, Department Of Pharmacology, Ankara, Turkey.

Vascular tonus is controlled by endothelium-derived relaxing factor (EDRF), endothelium-derived hyperpolarizing factor (EDHF) and endothelium-derived contracting factor (EDCF) under physiological circumstances. In pathological conditions, impairment of endothelium-derived relaxation can be caused by both decrease in EDRF release and increase in EDCF release. The increase in EDCF is observed with diseases such as hypertension and diabetes. Read More

Turk J Pharm Sci 2017 Aug 15;14(2):201-206. Epub 2017 Aug 15.

Hacettepe University, Faculty Of Pharmacy, Department Of Pharmaceutical Toxicology, Ankara, Turkey.

Eugenol is a volatile phenolic constituent of clove essential oil obtained from buds and leaves. It is a functional ingredient of numerous products which have been used in the pharmaceutical, food and cosmetic industry in restricted concentrations. Its derivatives have been used in medicine as a local antiseptic and anesthetic. Read More

Turk J Pharm Sci 2017 Aug 15;14(2):185-190. Epub 2017 Aug 15.

Hacettepe University, Faculty Of Pharmacy, Department Of Pharmaceutical Toxicology, Ankara, Turkey.

Objectives: Pendimethalin (-(1-ethylpropyl)-3,4-dimethyl-2,6-dinitrobenzeneamine) is a dinitroaniline herbicide compound which selectively controls weeds. It is a cell division and growth inhibitor. It descends plants in a short time after seedling. Read More