6,731,717 results match your criteria Animals : an open access journal from MDPI[Journal]

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The effect of ellagic acid on spinal cord and sciatica function in a mice model of multiple sclerosis.

J Biochem Mol Toxicol 2020 Jul 8:e22564. Epub 2020 Jul 8.

Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Multiple sclerosis (MS) is a well-known neurodegenerative disorder, causing toxicity in different organs, such as spinal cord tissue. The goal of this study was to investigate the protective effect of ellagic acid (EA) against spinal cord and sciatica function in cuprizone (Cup)-induced demyelination model. Animals were divided into six equal groups. Read More

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http://dx.doi.org/10.1002/jbt.22564DOI Listing
July 2020
1.925 Impact Factor

Anti-oxidant and anti-inflammatory effects of caffeic acid: in vivo evidences in a model of noise-induced hearing loss.

Food Chem Toxicol 2020 Jul 5:111555. Epub 2020 Jul 5.

Fondazione Policlinico Universitario A, Gemelli IRCCS, Roma, Italia; Department of Head and Neck Surgery, Università Cattolica del Sacro Cuore, Roma, Italia. Electronic address:

Scope: The imbalance of cellular redox status, in conjunction with the activation of inflammatory processes, have been considered common predominant mechanisms of noise-induced hearing loss. The identification of novel natural products as potential therapeutics, targeting oxidative stress and inflammatory pathways, is an emerging field. Here, we focused on the polyphenol caffeic acid (CA), the major representative of hydroxycinnamic acids and phenolic acid, in order to investigate its protective capacity in a model of sensorineural hearing loss induced by noise. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111555DOI Listing

Modulation by chronic stress and ketamine of ionotropic AMPA/NMDA and metabotropic glutamate receptors in the rat hippocampus.

Prog Neuropsychopharmacol Biol Psychiatry 2020 Jul 5:110033. Epub 2020 Jul 5.

Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. Electronic address:

Converging clinical and preclinical evidence has shown that dysfunction of the glutamate system is a core feature of major depressive disorder. In this context, the N-methyl-d-aspartate (NMDA) receptor antagonist ketamine has raised growing interest as fast acting antidepressant. Using the chronic mild stress (CMS) rat model of depression, performed in male rats, we aimed at analyzing whether hippocampal specific changes in subunit expression and regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) or NMDA ionotropic receptors and in metabotropic glutamate receptors could be associated with behavioral vulnerability/resilience to CMS. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.110033DOI Listing

Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.

Cell Rep 2020 Jul;32(1):107847

Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), 50009 Zaragoza, Spain; Aragon I+D Foundation (ARAID), Zaragoza, Spain; Nanoscience Institute of Aragon (INA), University of Zaragoza, 50018 Zaragoza, Spain; Department Biochemistry and Molecular and Cell Biology and Department Microbiology, Preventive Medicine and Public Health, University of Zaragoza, 50009 Zaragoza, Spain; CIBER-BBN, Madrid, Spain. Electronic address:

If not properly regulated, the inflammatory immune response can promote carcinogenesis, as evident in colorectal cancer (CRC). Aiming to gain mechanistic insight into the link between inflammation and CRC, we perform transcriptomics analysis of human CRC, identifying a strong correlation between expression of the serine protease granzyme A (GzmA) and inflammation. In a dextran sodium sulfate and azoxymethane (DSS/AOM) mouse model, deficiency and pharmacological inhibition of extracellular GzmA both attenuate gut inflammation and prevent CRC development, including the initial steps of cell transformation and epithelial-to-mesenchymal transition. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107847DOI Listing

The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP.

PLoS Genet 2020 Jul 8;16(7):e1008884. Epub 2020 Jul 8.

Department of Dermatology and Cutaneous Biology, Jefferson Institute of Molecular Medicine and PXE International Center of Excellence in Research and Clinical Care, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.

The membrane protein ANKH was known to prevent pathological mineralization of joints and was thought to export pyrophosphate (PPi) from cells. This did not explain, however, the presence of ANKH in tissues, such as brain, blood vessels and muscle. We now report that in cultured cells ANKH exports ATP, rather than PPi, and, unexpectedly, also citrate as a prominent metabolite. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008884DOI Listing

Comprehensive RNA-Seq profiling of the lung transcriptome of Bashbay sheep in response to experimental Mycoplasma ovipneumoniae infection.

PLoS One 2020 8;15(7):e0214497. Epub 2020 Jul 8.

College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China.

The Bashbay sheep (Ovis aries), an indigenous breed of Xinjiang, China, has many excellent characteristics. It is resistant to Mycoplasma ovipneumoniae infection, the causative agent of mycoplasma ovipneumonia, a chronic respiratory disease that is harmful to the sheep industry. To date, knowledge regarding the mechanisms responsible for M. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214497PLOS

A novel mutation in PDE6B in Spanish Water Dogs with early-onset progressive retinal atrophy.

Vet Ophthalmol 2020 Jul 8. Epub 2020 Jul 8.

Department of Small Animal Clinical Sciences, Veterinary Medical Center, Michigan State University, East Lansing, MI, USA.

Objective: To identify the underlying mutation in a recently identified early-onset progressive retinal atrophy (PRA) in the Spanish Water Dog (SWD) breed.

Animal Studied: Eighteen SWDs were used in this study. Six SWDs diagnosed with PRA and 12 phenotypically normal SWDs. Read More

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http://dx.doi.org/10.1111/vop.12792DOI Listing

The report of the use of patient-derived xenograft models in the development of anticancer drugs in Japan.

Cancer Sci 2020 Jul 8. Epub 2020 Jul 8.

Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, 277-8577, Japan.

Cell line-derived xenograft (CDX) models created by implanting cancer cell lines into immunodeficient mice have been largely contributed to develop cancer drug therapies. However, cell lines often lose their original biological characteristics through many passages and cancer tissues in CDX models have many cancer cells and few cancer stromal cells, therefore, CDX models are currently considered not suitable for predicting the results of clinical studies. On the other hand, patient-derived xenograft (PDX) models are gaining importance, in which human cancer biological characteristics and microenvironments are recreated by implanting tumor tissue into immunodeficient mice. Read More

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http://dx.doi.org/10.1111/cas.14564DOI Listing

Stall-side screening potential of a smartphone electrocardiogram recorded over both sides of the thorax in horses.

J Vet Intern Med 2020 Jul 8. Epub 2020 Jul 8.

Servicio de Cardiología, Hospital Clínico Veterinario, Universidad Cardenal Herrera CEU, CEU Universities, Valencia, Spain.

Background: Comparisons between smartphone ECG (SpECG) recordings obtained from the right and left sides of the thorax have not been reported in animals.

Objectives: To evaluate the screening potential of a SpECG obtained from both sides of the thorax and to compare the degree of agreement between the SpECG and a reference ECG (rECG) for measurement of the duration of baseline electrical deflections recorded over both sides of the thorax.

Animals: Fifty horses admitted to the equine hospital, university-owned horses, and horses from an endurance riding facility. Read More

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http://dx.doi.org/10.1111/jvim.15795DOI Listing

Surveys for ticks on wildlife hosts and in the environment at Asian longhorned tick (Haemaphysalis longicornis)-positive sites in Virginia and New Jersey, 2018.

Transbound Emerg Dis 2020 Jul 8. Epub 2020 Jul 8.

Southeastern Cooperative Wildlife Disease Study, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States.

Haemaphysalis longicornis, the Asian longhorned tick (ALT), is native to eastern Asia, but it has become invasive in several countries, including Australia, New Zealand, and recently in the eastern United States (US). To identify wild mammal and avian host species in the US, we conducted active wildlife surveillance in two states with known ALT infestations (Virginia and New Jersey). In addition, we conducted environmental surveys in both states. Read More

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http://dx.doi.org/10.1111/tbed.13722DOI Listing

First molecular characterization of the hepatitis E virus in humans in Cameroon: Confirmation of the HEV outbreak in Touboro, North-Cameroon.

J Med Virol 2020 Jul 8. Epub 2020 Jul 8.

Department of Virology, Centre Pasteur of Cameroon, Yaoundé, Cameroon.

Hepatitis E virus (HEV) is a major causative agent of acute viral hepatitis in many regions of the world including Africa. In Cameroon, there is no published molecular study on HEV in humans. However, based on serological assays, the first outbreak of HEV was detected in North-Cameroon. Read More

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http://dx.doi.org/10.1002/jmv.26277DOI Listing

Association of Outdoor Artificial Light at Night With Mental Disorders and Sleep Patterns Among US Adolescents.

JAMA Psychiatry 2020 Jul 8. Epub 2020 Jul 8.

Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland.

Importance: Indoor nighttime light exposure influences sleep and circadian rhythms and is known to affect mood-associated brain circuits in animals. However, little is known about the association between levels of nighttime outdoor light and sleep and mental health in the population, especially among adolescents.

Objective: To estimate associations of outdoor artificial light at night (ALAN) with sleep patterns and past-year mental disorder among US adolescents. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2020.1935DOI Listing

Combined Transplantation With Human Mesenchymal Stem Cells Improves Retinal Rescue Effect of Human Fetal RPE Cells in Retinal Degeneration Mouse Model.

Invest Ophthalmol Vis Sci 2020 Jul;61(8)

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Purpose: We verified whether fetal RPE (fRPE) cells and mesenchymal stem cells (MSCs) cotransplantation can combine the features of these two cell types and alleviate retinal degeneration in a retinal degenerative disease mouse model.

Methods: Tail vein injection of sodium iodate (NaIO3) was conducted to establish the retinal degenerative disease mouse model. MSCs and fRPE cells were transplanted either separately or combined in the subretinal space of retinal degenerative disease animals. Read More

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http://dx.doi.org/10.1167/iovs.61.8.9DOI Listing

Immune responses of meningococcal B outer membrane vesicles in middle-aged mice.

Pathog Dis 2020 Jul 8. Epub 2020 Jul 8.

Department of Immunology, Adolfo Lutz Institute, Sao Paulo, Brazil.

The elderly are more likely to die when infected with Neisseria meningitidis. Aging is associated with immune system dysfunctions that impair responses to vaccines and infections. Therefore, immunization of middle-aged individuals could be beneficial. Read More

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http://dx.doi.org/10.1093/femspd/ftaa028DOI Listing

The Prolyl Hydroxylase Inhibitor Dimethyl Oxalyl Glycine Decreases Early Gastrointestinal GVHD in Experimental Allogeneic Hematopoietic Cell Transplantation.

Transplantation 2020 Jun 29. Epub 2020 Jun 29.

Department of Internal Medicine, Division of Hematology & Blood and Marrow Transplantation, Markey Cancer Center, University of Kentucky, Lexington, KY.

Background: Prolyl hydroxylase inhibitors (PHI) promote stabilization of hypoxia-inducible factor-1 alpha (HIF-1α) and affect signaling cascades of inflammation and cell death. Their beneficial use in experimental models of ulcerative colitis and lung allograft rejection led us to test the effect of the PHI dimethyl oxalyl glycine (DMOG) in the pathophysiology of graft versus host disease (GVHD).

Methods: Acute GVHD was induced in lethally irradiated BALB/c mice. Read More

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http://dx.doi.org/10.1097/TP.0000000000003383DOI Listing

SEVERE ACUTE TOXIC EXPOSURES IN CHILDREN AND ADOLESCENTS: CASE SERIES.

Rev Paul Pediatr 2021 3;39:e2019262. Epub 2020 Jul 3.

Universidade Estadual de Campinas, Campinas, SP, Brazil.

Objective: To describe a case series of severe acute toxic exposures (SATE) in individuals <20 years old followed-up by a regional Poison Control Center (PCC).

Methods: Descriptive cross-sectional study. All patients who were <20yo and classified as score 3 (severe) and 4 (fatal) following Poisoning Severity Score were included for analysis. Read More

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http://dx.doi.org/10.1590/1984-0462/2021/39/2019262DOI Listing

The influence of platelet-rich plasma (PRP) on colonic anastomosis healing impaired by intraperitoneal 5-flourouracil application. An experimental study.

Acta Cir Bras 2020 Jul 6;35(5):e202000504. Epub 2020 Jul 6.

MD, Department of General Surgery, University of Health Sciences Adana City Training and Research Hospital, Adana, Turkey. Acquisition of data.

Purpose: 5-flourourasil (5-FU) is commonly used for early intraperitoneal chemotherapy in colorectal or appendiceal cancer patients with peritoneal carcinomatosis. Due to its effect, anastomosis healing can be impaired and leads to anastomotic leakage. In this study, we aimed to investigate the potential healing effect of platelet-rich plasma (PRP) on colonic anastomosis impaired by intraperitoneal 5-flourouracil application. Read More

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http://dx.doi.org/10.1590/s0102-865020200050000004DOI Listing

Opinion paper: Severe Acute Respiratory Syndrome Coronavirus 2 and domestic animals: what relation?

Animal 2020 Jun 23:1-4. Epub 2020 Jun 23.

UMR Virologie, ENVA, INRAE, ANSES Laboratoire de santé animale, 94700Maisons-Alfort, France.

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http://dx.doi.org/10.1017/S1751731120001639DOI Listing

[Great Folk Medicine Book from Poljica (Bratulic's Folk Medicine Book)].

Acta Med Hist Adriat 2020 Jun;18(1):89-104

Ante Topića Mimare 23, 10090 Zagreb, Hrvatska. E-mail:

The paper presents a folk recipe collection manuscript written by an unknown author in Poljica area, in the 18th century. It is owned by the philologist, historian of literature and bibliophile, Josip Bratulic. Therefore, the author suggests that this recipe collection should bear the name Great folk medicine book from Poljica (Bratulic's folk medicine book). Read More

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First glimpse into the origin and spread of the Asian longhorned tick, Haemaphysalis longicornis, in the United States.

Zoonoses Public Health 2020 Jul 7. Epub 2020 Jul 7.

Center for Vector Biology, Department of Entomology, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.

Established populations of Asian longhorned ticks (ALT), Haemaphysalis longicornis, were first identified in the United States (US) in 2017 by sequencing the mitochondrial cytochrome c oxidase subunit I (cox1) 'barcoding' locus followed by morphological confirmation. Subsequent investigations detected ALT infestations in 12, mostly eastern, US states. To gain information on the origin and spread of US ALT, we (1) sequenced cox1 from ALT populations across 9 US states and (2) obtained cox1 sequences from potential source populations [China, Japan and Republic of Korea (ROK) as well as Australia, New Zealand and the Kingdom of Tonga (KOT)] both by sequencing and by downloading publicly available sequences in NCBI GenBank. Read More

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http://dx.doi.org/10.1111/zph.12743DOI Listing

The thermal ecology and physiology of reptiles and amphibians: A user's guide.

J Exp Zool A Ecol Integr Physiol 2020 Jul 8. Epub 2020 Jul 8.

Department of Biology, California State University, Fresno, California.

Research on the thermal ecology and physiology of free-living organisms is accelerating as scientists and managers recognize the urgency of the global biodiversity crisis brought on by climate change. As ectotherms, temperature fundamentally affects most aspects of the lives of amphibians and reptiles, making them excellent models for studying how animals are impacted by changing temperatures. As research on this group of organisms accelerates, it is essential to maintain consistent and optimal methodology so that results can be compared across groups and over time. Read More

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http://dx.doi.org/10.1002/jez.2396DOI Listing

Cellular dynamics of double fertilization and early embryogenesis in flowering plants.

J Exp Zool B Mol Dev Evol 2020 Jul 8. Epub 2020 Jul 8.

Department of Plant and Soil Sciences, University of Kentucky, Lexington, Kentucky.

Flowering plants (angiosperms) perform a unique double fertilization in which two sperm cells fuse with two female gamete cells in the embryo sac to develop a seed. Furthermore, during land plant evolution, the mode of sexual reproduction has been modified dramatically from motile sperm in the early-diverging land plants, such as mosses and ferns as well as some gymnosperms (Ginkgo and cycads) to nonmotile sperm that are delivered to female gametes by the pollen tube in flowering plants. Recent studies have revealed the cellular dynamics and molecular mechanisms for the complex series of double fertilization processes and elucidated differences and similarities between animals and plants. Read More

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http://dx.doi.org/10.1002/jez.b.22981DOI Listing

The phenotypic characteristics and relational database for Vietnamese native pig populations.

Anim Sci J 2020 Jan;91(1):e13411

Institute of Agrobiological Sciences, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.

Although there are a number of Vietnamese native pig (VnP) populations, some are on the verge of extinction, and therefore adequate management and conservation are necessary. In this study, we conducted a field survey of VnP populations and analyzed interrelationships among their characteristics. We also established a relational database for management of field data on these populations. Read More

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http://dx.doi.org/10.1111/asj.13411DOI Listing
January 2020

Photobiomodulation modulates the expression of inflammatory cytokines during the compensatory hypertrophy process in skeletal muscle.

Lasers Med Sci 2020 Jul 7. Epub 2020 Jul 7.

Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), Rua Vergueiro, 349, São Paulo, SP, 01504001, Brazil.

Compensatory hypertrophy (CH) occurs due to excessive mechanical load on a muscle, promoting an increase in the size of muscle fibers. In clinical practice, situations such as partial nerve injuries, denervation, and muscle imbalance caused by trauma to muscles and nerves or diseases that promote the loss of nerve conduction can induce CH in muscle fibers. Photobiomodulation (PBM) has demonstrated beneficial effects on muscle tissue during CH. Read More

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http://dx.doi.org/10.1007/s10103-020-03095-yDOI Listing

Feedlot performance of Tanzanian Shorthorn Zebu finished on local feed resources.

Authors:
D E Mushi

Trop Anim Health Prod 2020 Jul 7. Epub 2020 Jul 7.

Department of Animal, aquaculture and Range Sciences, Sokoine University of Agriculture, Morogoro, Tanzania.

A study was conducted in Hanang District to assess potential for on-farm feedlot finishing of Tanzanian Shorthorn Zebu (TSHZ) in dry season using locally available feed resources. A total of 65 (2-3 years old, 150-250 kg LWT) steers were randomly distributed into two dietary treatments in three villages. The steers were finished either in feedlots using compounded diets or under free grazing in accordance with farmers' practice. Read More

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http://dx.doi.org/10.1007/s11250-020-02346-yDOI Listing

Evaluation of the efficacy of platelet-rich plasma in preventing postoperative intraabdominal adhesions.

Turk J Surg 2020 Mar 18;36(1):53-58. Epub 2020 Mar 18.

Department of General Surgery, Selcuk University School of Medicine, Konya, Turkey.

Objectives: Postoperative intraabdominal adhesions still maintain their currency as serious causes of morbidity and mortality. This study aimed at evaluating the role of platelet-rich plasma (PRP) in the prevention of intraabdominal adhesions.

Material And Methods: A total of 16 healthy rabbits were used within the scope of the study. Read More

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http://dx.doi.org/10.5578/turkjsurg.4421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315448PMC

Development of a Pemetrexed/Folic Acid Nanoformulation: Synthesis, Characterization, and Efficacy in a Murine Colorectal Cancer Model.

ACS Omega 2020 Jun 16;5(25):15424-15432. Epub 2020 Jun 16.

Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, Oregon 97201, United States.

The folate analogue pemetrexed (PEM) is an approved therapeutic for non-small cell lung cancer and malignant pleural mesothelioma with the potential for broader application in combination therapies. Here, we report the development of a nanoformulation of PEM and its efficacy against the CT26 murine colorectal cancer cell line and . Utilizing layer-by-layer deposition, we integrate PEM, along with folic acid (FA), onto a fluorescent polystyrene nanoparticle (NP) substrate. Read More

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http://dx.doi.org/10.1021/acsomega.0c01550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331029PMC

Magnetic Resonance Imaging as a Novel Method for Elucidating Sediment Burrow Structures and Functions.

ACS Omega 2020 Jun 15;5(25):14933-14941. Epub 2020 Jun 15.

Center for Regional Environmental Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan.

Burrow structures produced by various benthic animals in sediments are important components of aquatic ecosystems, allowing the circulation of interstitial water via ingress of fresh bottom water into the burrows upon feeding and intraburrow migration. Although X-ray computed tomography has been used to visualize burrow structures, it could not reveal the structures in the soft mud in Lake Kasumigaura, where evaluation of the water-circulation effect of burrows is an important issue. Here, we describe the first attempt to use magnetic resonance (MR) imaging (MRI) to visualize intact burrow structures in the soft mud sediment cores collected from a eutrophic lake. Read More

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http://dx.doi.org/10.1021/acsomega.8b00192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330907PMC

Recursive sequence generation in monkeys, children, U.S. adults, and native Amazonians.

Sci Adv 2020 Jun 26;6(26):eaaz1002. Epub 2020 Jun 26.

Carnegie Mellon University, Pittsburgh, PA, USA.

The question of what computational capacities, if any, differ between humans and nonhuman animals has been at the core of foundational debates in cognitive psychology, anthropology, linguistics, and animal behavior. The capacity to form nested hierarchical representations is hypothesized to be essential to uniquely human thought, but its origins in evolution, development, and culture are controversial. We used a nonlinguistic sequence generation task to test whether subjects generalize sequential groupings of items to a center-embedded, recursive structure. Read More

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http://dx.doi.org/10.1126/sciadv.aaz1002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319756PMC

Sperm DNA Integrity and Male Fertility in Farm Animals: A Review.

Front Vet Sci 2020 19;7:321. Epub 2020 Jun 19.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.

The accurate prediction of male fertility is of major economic importance in the animal breeding industry. However, the results of conventional semen analysis do not always correlate with field fertility outcomes. There is evidence to indicate that mammalian fertilization and subsequent embryo development depend, in part, on the inherent integrity of the sperm DNA. Read More

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http://dx.doi.org/10.3389/fvets.2020.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317013PMC

New Biological Morphogenetic Methods for Evolutionary Design of Robot Bodies.

Front Bioeng Biotechnol 2020 19;8:621. Epub 2020 Jun 19.

Robotics and Autonomous Systems Group, Cyber-Physical Systems, Data61, Commonwealth Scientific and Industrial Research Organization (CSIRO), Pullenvale, QLD, Australia.

We present some currently unused morphogenetic mechanisms from evolutionary biology and guidelines for transfer to evolutionary robotics. (1) DNA patterns providing mutation of mutability, lead to canalization of evolvable bauplans, via kin selection. (2) Morphogenetic mechanisms (i) Epigenetic cell lines provide functional cell types, and identification of cell descent. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317032PMC

Type III Secretion 1 Effector Gene Diversity Among Isolates From Coastal Areas in China.

Front Cell Infect Microbiol 2020 18;10:301. Epub 2020 Jun 18.

Department of Marine Biology, College of Oceanography, Hohai University, Nanjing, China.

Vibrios, which include more than 120 valid species, are an abundant and diverse group of bacteria in marine and estuarine environments. Some of these bacteria have been recognized as pathogens of both marine animals and humans, and therefore, their virulence mechanisms have attracted increasing attention. The type III secretion system (T3SS) is an important virulence determinant in many gram-negative bacteria, in which this system directly translocates variable effectors into the host cytosol for the manipulation of the cellular responses. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318850PMC

Use of adrenaline continuous infusion to treat hypotension during general anaesthesia in a cow and a calf.

Ir Vet J 2020 2;73:13. Epub 2020 Jul 2.

UCD Veterinary Hospital, University College Dublin, Belfield, Dublin 4, Eircode: D04 V1W8 Ireland.

Background: Hypotension is one of the most common complications observed during inhalation anaesthesia in veterinary patients. Treatment of hypotension in cattle is more challenging than in other species, owing to the limited number of drugs licensed in food producing animals. The use of adrenaline as an infusion to support blood pressure has not been described previously in bovines. Read More

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http://dx.doi.org/10.1186/s13620-020-00164-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333263PMC

Investigation of Infection in Aborted Fetuses of Sheep Using PCR: A Study in North Khorasan Province, Iran.

Vet Med Int 2020 20;2020:7913912. Epub 2020 Jun 20.

Student Research Committee, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

is a zoonotic obligate intracellular protozoan parasite that infects warm-blooded animals as well as humans worldwide. The purpose of this study was to delineate the prevalence of infection in aborted fetuses of sheep in North Khorasan province, Iran. Three hundred and ninety-nine samples of the liver (133 samples), placenta (133 samples), and brain (133 samples) from 133 aborted fetuses of sheep were collected from 2015 to 2017. Read More

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http://dx.doi.org/10.1155/2020/7913912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322599PMC

Chronic venous ulcers: a review on treatment with fibrin sealant and prognostic advances using proteomic strategies.

J Venom Anim Toxins Incl Trop Dis 2020 Jun 22;26:e20190101. Epub 2020 Jun 22.

Department of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Botucatu Medical School (FMB), São Paulo State University (UNESP), Botucatu, SP, Brazil.

Venous ulcers are the main causes of chronic lower-limb ulcers. The healing difficulties encourage the research and development of new products in order to achieve better therapeutic results. Fibrin sealant is one of these alternatives. Read More

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http://dx.doi.org/10.1590/1678-9199-JVATITD-2019-0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315627PMC

Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design.

Front Microbiol 2020 19;11:1313. Epub 2020 Jun 19.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

H7N9 influenza virus was first isolated in 2013 and has caused five epidemic waves among humans to date. Treatment opinions are currently limited. Previously, we characterized a human neutralizing antibody, HNIgGA6, by isolating rearranged heavy- and light-chain genes from convalescent patients. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316883PMC

The Magnetic Receptor of M7: Gene Clone and Its Heterologous Expression in .

Front Microbiol 2020 19;11:1112. Epub 2020 Jun 19.

Hubei International Scientific and Technological Cooperation Base of Traditional Fermented Foods, Huazhong Agricultural University, Wuhan, China.

It is well known that many organisms can perceive the magnetic field (MF), including the geomagnetic field, but how to feel MF is unclear. Recently, a study has claimed that a biological compass, namely a complex of the magnetic receptor (MagR) and blue light (BL) receptor (cryptochrome), has been found in , , and , which may bring some new ideas to explore the mechanism of biomagnetism. spp. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318567PMC

Imaging Biomarkers and Pathobiological Profiling in a Rat Model of Drug-Induced Interstitial Lung Disease Induced by Bleomycin.

Front Physiol 2020 19;11:584. Epub 2020 Jun 19.

Department of Medical Radiation Physics, Institution of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.

A large number of systemically administered drugs have the potential to cause drug-induced interstitial lung disease (DIILD). We aim to characterize a model of DIILD in the rat and develop imaging biomarkers (IBs) for detection and quantification of DIILD. In this study, Sprague-Dawley rats received one single dose of intratracheal (i. Read More

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http://dx.doi.org/10.3389/fphys.2020.00584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317035PMC

Anxious Behavior of Adult CD1 Mice Perinatally Exposed to Low Concentrations of Ethanol Correlates With Morphological Changes in Cingulate Cortex and Amygdala.

Front Behav Neurosci 2020 19;14:92. Epub 2020 Jun 19.

Instituto de Biología Celular y Neurociencia (IBCN), Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina.

Perinatal ethanol (EtOH) exposure is associated with high incidence of behavioral disorders such as depression and anxiety. The cerebral areas related with these consequences involve the corticolimbic system, in particular the prefrontal cortex, hippocampus, amygdala, and cingulate cortex, although the latter has not been thoroughly studied yet. Different animal models of prenatal or perinatal EtOH exposure have reported morphofunctional alterations in the central nervous system, which could explain behavioral disorders along life; these results focus on youth and adolescents and are still controversial. Read More

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http://dx.doi.org/10.3389/fnbeh.2020.00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319189PMC

Effect of pre-supplementation with crude extracts on body weight and consequence responses of leukocytes and immune organs in fancy carp following inoculation with .

Vet World 2020 May 31;13(5):1010-1016. Epub 2020 May 31.

Department of Microbiology, Faculty of Veterinary Medicine, Mahanakorn University of Technology, Bangkok, Thailand.

Aim: The present study aimed at highlighting the effects of oyster mushroom (), as a dietary supplement on growth performance, differential leukocytes population, and histological changes of melanomacrophage centers (MMCs) in spleen and kidney of fancy carp on bacterial infection.

Materials And Methods: A total of 60 fancy carp were allocated into four groups according to feed formulations including; (1) basal diet with 2% crude extract of , (2) basal diet with 2% b-glucan, whereas Group 3, and Group 4 were positive and negative control, which were fed only basal diet. Diets were provided for 30 days, thereafter, fish of Group 1 to Group 3 were intraperitoneally injected with (1. Read More

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http://dx.doi.org/10.14202/vetworld.2020.1010-1016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311868PMC

Incidence risk of bronchopneumonia in newborn calves associated with intrauterine diselementosis.

Vet World 2020 May 29;13(5):987-995. Epub 2020 May 29.

Laboratory of Environmental Biogeochemistry, V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Moscow, Russia.

Background And Aim: Macro- and micro-elements are required to ensure the normal course of biochemical processes in the development of an animal's body. Any excess, deficiency, or imbalance in chemical elements in an animal's body can cause the development of various latent or clinically expressed pathological conditions. Diselementosis in pregnant cows may lead to impaired embryo and fetal development, as well as reduced neonatal viability. Read More

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http://dx.doi.org/10.14202/vetworld.2020.987-995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311866PMC

antiproliferation activity of leaves ethanol extract and its combination with canine interferons on several tumor-derived cell lines.

Vet World 2020 May 19;13(5):931-939. Epub 2020 May 19.

Division of Pharmacy, Faculty of Veterinary Medicine; IPB University, Bogor, Indonesia.

Background And Aim: Tumor disorder is one of the degenerative diseases that affected human and animals and recently is tend to increase significantly. The treatment of tumor diseases can be performed through surgical, chemotherapy, radiotherapy, biological substances, and herbs medicine. leaves extract known to have an antiproliferation activity, while interferons (IFNs) one of the cytokines that first used as an antiviral agent was also known to have antitumor activity. Read More

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http://dx.doi.org/10.14202/vetworld.2020.931-939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311872PMC

Biochemical and immunological investigation of fascioliasis in cattle in Egypt.

Vet World 2020 May 18;13(5):923-930. Epub 2020 May 18.

Department of Food Hygiene, Faculty of Veterinary Medicine, New Valley University, El-Kharga, Egypt.

Background And Aim: and are two commonly reported liver flukes that cause fascioliasis in ruminants. Among the members of the genus , was identified in the study area. Fascioliasis is a major disease that affects the production of livestock by causing liver damage. Read More

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http://dx.doi.org/10.14202/vetworld.2020.923-930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311878PMC

Cardiac troponin I as a cardiac biomarker has prognostic and predictive value for poor survival in Egyptian buffalo calves with foot-and-mouth disease.

Vet World 2020 May 14;13(5):890-895. Epub 2020 May 14.

Department of Animal Medicine, Faculty of Veterinary Medicine, Alexandria University, Egypt.

Background And Aim: Foot-and-mouth disease (FMD) causes huge economic losses in Egypt due to reductions in the production of red meat, milk, and milk by-products and can also lead to myocarditis in young animals. The aim of our study was to evaluate cardiac biomarkers, in particular cardiac troponin I (cTnI), and to reveal the relations of cardiac biomarkers with poor survival in FMD-infected Egyptian buffalo calves.

Materials And Methods: Forty-two Egyptian buffalo calves were included in this study. Read More

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http://dx.doi.org/10.14202/vetworld.2020.890-895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311879PMC

Celery () as a potential antibacterial agent and its effect on cytokeratin-17 and other healing promoters in skin wounds infected with methicillin-resistant .

Vet World 2020 May 9;13(5):865-871. Epub 2020 May 9.

Faculty of Veterinary Medicine, University of Wijaya Kusuma Surabaya, East Java, 60225, Indonesia.

Background And Aim: Antimicrobial resistance is a global problem caused by extensive utilization of antibiotics that promote gene resistant among bacteria, including . This study aimed to analyze the potential effects of celery () extract as an antioxidant and antimicrobial agent against methicillin-resistant (MRSA), and .

Materials And Methods: Celery was extracted and tested against a MRSA isolate . Read More

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http://dx.doi.org/10.14202/vetworld.2020.865-871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311862PMC

Ophthalmic findings in sheep treated with closantel in Curitiba, Brazil.

Vet World 2020 May 8;13(5):860-864. Epub 2020 May 8.

Department of Veterinary Sciences, Federal University of Parana, Curitiba, Brazil.

Background And Aim: Closantel is a widely used anti-parasitic drug that is known to cause ophthalmic problems that lead to blindness. The aim of this study was to investigate the possible electroretinographic changes in sheep that received closantel.

Materials And Methods: Twenty-four 30-day-old Suffolk sheep were split into control group (12 animals) and closantel group (12 animals). Read More

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http://dx.doi.org/10.14202/vetworld.2020.860-864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311881PMC

Environmental contaminants in coastal populations: Comparisons with the National Health and Nutrition Examination Survey (NHANES) and resident dolphins.

Sci Total Environ 2019 Dec 23;696. Epub 2019 Aug 23.

National Institute of Standards and Technology, Charleston, SC, USA.

Background: People living in coastal communities are at risk for exposure to environmental hazards, including legacy chemicals. We can use databases such as NHANES to assess whether contaminants in coastal communities are present in higher levels than in the United States overall. We can use information from studies of local animal populations to assess which of these contaminants could have been transferred to people from their shared environment. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.134041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340099PMC
December 2019

Toxicity of fluralaner, a companion animal insecticide, relative to industry-leading agricultural insecticides against resistant and susceptible strains of filth flies.

Sci Rep 2020 Jul 7;10(1):11166. Epub 2020 Jul 7.

Department of Entomology, Cornell University, Ithaca, NY, 14853, USA.

Filth flies cause billions of dollars of losses annually to the animal production industry. Fluralaner is a relatively new pesticide currently sold for control of fleas, ticks, and mites on companion animals and poultry. We examined the efficacy of fluralaner against three species of filth flies. Read More

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http://dx.doi.org/10.1038/s41598-020-68121-zDOI Listing

Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques.

Cell Res 2020 Jul 7. Epub 2020 Jul 7.

Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.

The 2019 novel coronavirus (SARS-CoV-2) outbreak is a major challenge for public health. SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases, with a mortality rate of ~6.4% worldwide (based on World Health Organization daily situation report). Read More

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http://dx.doi.org/10.1038/s41422-020-0364-zDOI Listing

High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.

Sci Rep 2020 Jul 7;10(1):11123. Epub 2020 Jul 7.

Department of Comparative Biomedicine and Food Science, University of Padua, 35020, Padua, Italy.

The presence of extended-spectrum β-lactamase (ESBL) or plasmid-mediated AmpC β-lactamase (pAmpC)-producing Escherichia coli (ESBL/pAmpC-EC) in livestock is a public health risk given the likelihood of their transmission to humans via the food chain. We conducted whole genome sequencing on 100 ESBL/pAmpC-EC isolated from the broiler production to explore their resistance and virulence gene repertoire, characterise their plasmids and identify transmission events derived from their phylogeny. Sequenced isolates carried resistance genes to four antimicrobial classes in addition to cephalosporins. Read More

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http://dx.doi.org/10.1038/s41598-020-68036-9DOI Listing
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