6,803,422 results match your criteria Animal welfare South Mimms England[Journal]

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Early graft function and intrarenal resistant index after kidney transplantation using Biolasol - a new solid organ preservation fluid.

Artif Organs 2020 May 28. Epub 2020 May 28.

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland.

Background: Biolasol is a newly developed preserving solution for cold organ storage prior to transplantation. To date, only animal model experiments results are available.

Objective: The aim of this single center analysis was to summarize the clinical experience concerning the early post-transplant course of kidney grafts preserved with Biolasol in comparison with other preservation solutions. Read More

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http://dx.doi.org/10.1111/aor.13742DOI Listing

Two novel lsa(E)-carrying mobile genetic elements in Streptococcus suis.

J Antimicrob Chemother 2020 May 28. Epub 2020 May 28.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, P. R. China.

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http://dx.doi.org/10.1093/jac/dkaa199DOI Listing

Direct-write 3D printing and characterization of a GelMA-based biomaterial for intracorporeal tissue engineering.

Biofabrication 2020 May 28. Epub 2020 May 28.

Mechanical and Aerospace Engineering, The Ohio State University, Columbus, Ohio, UNITED STATES.

We develop and characterize a biomaterial formulation and robotic methods tailored for intracorporeal tissue engineering (TE) via direct-write (DW) 3D printing. Intracorporeal TE is defined as the biofabrication of 3D TE scaffolds inside of a living patient, in a minimally invasive manner. A biomaterial for intracorporeal TE requires to be 3D printable and crosslinkable via mechanisms that are safe to native tissues and feasible at physiological temperature (37 °C). Read More

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http://dx.doi.org/10.1088/1758-5090/ab97a1DOI Listing

CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues.

iScience 2020 May 15;23(6):101163. Epub 2020 May 15.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; Institut National de la Santé et de la Recherche Médicale (Inserm), Languedoc Roussillon, France. Electronic address:

Cyclin-dependent kinases (CDKs) are emerging regulators of adipose tissue metabolism. Here we aimed to explore the role of CDK7 in thermogenic fat. We found that CDK7 brown adipose tissue (BAT)-specific knockout mice (Cdk7) have decreased BAT mass and impaired β3-adrenergic signaling and develop hypothermia upon cold exposure. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101163DOI Listing

Novel potent antiplatelet thrombotic agent derived from biguanide for ischemic stroke.

Eur J Med Chem 2020 May 18;200:112462. Epub 2020 May 18.

Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Platelet thrombosis is the main pathogeny resulting in the low curability of ischemic stroke, a leading cause of mortality and disability worldwide. Metformin, a biguanide derivative that is the first-line oral medicine for type 2 diabetes, alleviates the severity of ischemic stroke in diabetic patients and suppresses platelet activation in experimental animal model. However, the clinical implementation of commercial biguanide analogs for stroke related to platelet thrombosis remains challenging due to its weak potency, poor pharmacokinetic characteristics and possible hypoglycemia. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112462DOI Listing

Digoxin: Pharmacology and toxicology-A review.

Environ Toxicol Pharmacol 2020 May 7;79:103400. Epub 2020 May 7.

Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic. Electronic address:

Digoxin is a cardiac glycoside used as drug in case of heart problems, including congestive heart failure, atrial fibrillation or flutter, and certain cardiac arrhythmias. It has a very narrow therapeutic window of the medication. Digoxin is toxic substance with well known cardiotoxic effect. Read More

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http://dx.doi.org/10.1016/j.etap.2020.103400DOI Listing

Cysteamine triggered "turn-on" fluorescence sensor for total detection of fumonisin B, B and B.

Food Chem 2020 May 18;327:127058. Epub 2020 May 18.

College of Animal Sciences/ College of Life Science, Yangtze University, Jingzhou 434023, China. Electronic address:

A "turn-on" fluorescence sensor was developed for total detection of fumonisin B, B and B (FB, FB and FB) in maize samples. Rhodamine B isothiocyanate (RBITC) and gold nanoparticles (AuNPs) were employed as the energy donor-acceptor pairs. The intensity of restored fluorescence was inversely proportional to the concentration of the FBs. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127058DOI Listing

Role of arginine kinase in Paramecium tetraurelia (Ciliophora, Peniculida): Subcellular localization of AK3 and phosphoarginine shuttle system in cilia.

Eur J Protistol 2020 Apr 23;74:125705. Epub 2020 Apr 23.

Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Science and Technology, Kochi University, Kochi 780-8520, Japan.

The ciliate Paramecium tetraurelia has four arginine kinase genes (AK1, AK2, AK3, and AK4). Of these genes, only AK3 has a signal sequence for farnesylation, a post-translational modification that enables anchoring of the modified enzyme to the ciliary membrane. To confirm this modification, AK3 was synthesized using a cell-free protein synthesis system and the peptide masses were analyzed using peptide mass fingerprinting (PMF). Read More

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http://dx.doi.org/10.1016/j.ejop.2020.125705DOI Listing

Design, synthesis, and biological evaluation of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents.

Eur J Med Chem 2020 May 1;198:112396. Epub 2020 May 1.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, PR China. Electronic address:

A novel series of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents were designed, synthesized, biologically evaluated. Compounds 3n, 3o and 3j proved to be good NQO1 substrates that showed increased metabolic rates relative to that of β-lapachone. In addition, 3n, 3o and 3j potently inhibited the growth of NQO1-rich breast cancer MCF-7 cell, liver hepatocellular HepG2 cell, and lung cancer A549 cell. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112396DOI Listing

Moringa oleifera leaves extract enhances fresh and cryopreserved semen characters of Barki rams.

Theriogenology 2020 May 13;153:133-142. Epub 2020 May 13.

Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Menoufia University, Sheben El-Koom, 32512, Egypt. Electronic address:

This study was carried out to evaluate the efficacy of Moringa oleifera leaves extract (MOLE) to improve the characters of fresh and cryopreserved semen of Barki rams compared to vitamin E and Selenium combination. Twenty-four mature Barki rams (50-70 Kg) were randomly assigned into three groups, eight rams each. The first group was given distilled water orally. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2020.04.007DOI Listing

Effects of concentrated poultry operations and cropland manure application on antibiotic resistant Escherichia coli and nutrient pollution in Chesapeake Bay watersheds.

Sci Total Environ 2020 May 13;735:139401. Epub 2020 May 13.

Division of Environmental Health Sciences, University of California, Berkeley School of Public Health, 2121 Berkeley Way, Berkeley, CA 94704, United States of America. Electronic address:

Manure from poultry operations is typically applied to nearby cropland and may affect nutrient loading and the spread of antibiotic resistance (ABR). We analyzed the concentrations of nitrogen and phosphorus and the occurrence of ABR in Escherichia coli (E. coli) and extra-intestinal pathogenic E. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139401DOI Listing

Dynamics of bacteriophages in gut of giant pandas reveal a potential regulation of dietary intake on bacteriophage composition.

Sci Total Environ 2020 May 19;734:139424. Epub 2020 May 19.

Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangdong Academy of Science, Guangzhou, China. Electronic address:

Fecal samples of cubs and adults of giant pandas were examined to determine the effects of diets on the diversity and dynamics of gut bacteriophages. Enterobacteria phage, Salmonella phage, Escherichia phage, Shigella phage, Klebsiella phage, and Lactococcus phage were found to be dominant in both cub and adult samples. Citrobacter phage, Cronobacter phage, Pectobacterium phage, Erwinia phage, Dickeya phage, Erwinia phage, Enterococcus phage, and Pseudomonas phage were more abundant in adults, while Lactococcus phage, Streptococcus phage, Lactobacillus phage, and Leuconostoc phage were more abundant in cubs. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139424DOI Listing

Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta.

Stem Cell Res 2020 May 20;46:101849. Epub 2020 May 20.

Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA; Department of Women's Health, Spectrum Health System, Grand Rapids, MI 49341, USA. Electronic address:

The Wnt pathway co-receptor, Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5), labels tumor-prone stem cell populations in certain types of tissue. In this study, we show that ARID1A and PIK3CA mutations in LGR5 cells result in renal angiosarcomas in adult mice. The tumors originate in the renal medulla. Read More

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http://dx.doi.org/10.1016/j.scr.2020.101849DOI Listing

Control it and it is yours: Children's reasoning about the ownership of living things.

Cognition 2020 May 25;202:104319. Epub 2020 May 25.

Department of Psychology, University of Toronto, Canada. Electronic address:

One of the hallmarks of ownership is the right to control one's property. Living beings thus pose an interesting puzzle for ownership, since they have some capacity to decide what happens to themselves-they can direct their own motion, pursue their own goals, and make their own decisions. Recent work has shown that adults consider this autonomy to be the key factor in determining whether a human (or human-like) being can be owned. Read More

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http://dx.doi.org/10.1016/j.cognition.2020.104319DOI Listing

Okanin in Coreopsis tinctoria Nutt is a major quorum-sensing inhibitor against Chromobacterium violaceum.

J Ethnopharmacol 2020 May 25:113017. Epub 2020 May 25.

Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps/College of Life Sciences, China; College of Animal Sciences/Key Laboratory of Tarim Animal Husbandry & Science Technology of Xinjiang Production & Construction Corps, Tarim University, Alar, 86-843300, China. Electronic address:

Ethnopharmacological Relevance: Coreopsis tinctoria Nutt has various medical and functional properties and its flower is widely used as health-care tea to decrease blood glucose and to lower blood lipids. However, the quorum sensing (QS) inhibition activity of Coreopsis tinctoria Nutt flower remains unclear.

Aim Of The Study: To assess inhibitory activity against quorum sensing by Chromobacterium violaceum, to identify the chemical composition of the extracts and to disclose the action mechanism of separated compound. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113017DOI Listing

Expression and function assessment of two serpin-type serine protease inhibitors from Haemaphysalis doenitzi.

Res Vet Sci 2020 May 20;132:1-9. Epub 2020 May 20.

Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China. Electronic address:

Serine protease inhibitors (serpins) in ticks are implicated in the modulation of the vertebrate host response to the tick bite. Experimentally, it has been demonstrated that serpins interfere with tick-borne pathogen transmission. However, knowledge on serpins in the tick Haemaphysalis doenitzi is lacking. Read More

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http://dx.doi.org/10.1016/j.rvsc.2020.05.015DOI Listing

Welfare of horses from Mexico and the United States of America transported for slaughter in Mexico: Fitness profiles for transport and pre-slaughter logistics.

Prev Vet Med 2020 May 16;180:105033. Epub 2020 May 16.

Department of Animal Production & Food Science, Agri-Food Institute of Aragon (IA2), University of Zaragoza, Zaragoza, Spain.

Every year thousands of horses from Mexico and the United States of America (USA) are transported to slaughter in Mexico, but little is known about their welfare or pre-slaughter logistics. In this study, we recorded the origin, sex, age and condition of horses (121 journeys, 2648 animals) upon arrival to an abattoir in northern Mexico, including transport details. Horse welfare was measured indirectly via individual scores for body condition, coat quality, lameness, ocular and nasal discharge, as well as reactivity to a chute restraint test, all performed shortly after unloading. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2020.105033DOI Listing

Decellularized Tissues as Platforms for In Vitro Modeling of Healthy and Diseased Tissues.

Acta Biomater 2020 May 25. Epub 2020 May 25.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. BMS J257, Gainesville, FL USA 32611. Electronic address:

Biomedical engineers are at the forefront of developing novel treatments to improve human health, however, many products fail to translate to clinical implementation. In vivo pre-clinical animal models, although the current best approximation of complex disease conditions, are limited by reproducibility, ethical concerns, and poor accurate prediction of human response. Hence, there is a need to develop physiologically relevant, low cost, scalable, and reproducible in vitro platforms to provide reliable means for testing drugs, biomaterials, and tissue engineered products for successful clinical translation. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.031DOI Listing

Microminipig: A Suitable Animal Model to Estimate Oral Absorption of Sustained-Release Formulation in Humans.

Int J Pharm 2020 May 25:119457. Epub 2020 May 25.

Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.

We investigated the gastrointestinal absorption characteristics of oral sustained-release formulations in microminipigs, dogs, and monkeys in order to clarify the similarities in absorption properties between these animals and humans. Time profiles of oral absorption of nifedipine and valproic acid were calculated from the plasma concentration-time profiles of the drugs by a deconvolution method. The curves for both drugs in microminipigs were close to or slightly higher than those in humans, whereas those in monkeys were lower. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119457DOI Listing

Organs infected with Trypanosoma cruzi and DTU identification in the naturally infected rodent Octodon degus.

Exp Parasitol 2020 May 25:107931. Epub 2020 May 25.

Programa de Biología Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile. Electronic address:

Chagas disease is a public health problem in America. Its parasite, Trypanosoma cruzi, presents different discrete typing units (DTUs), colonizes organs of mammalian hosts in chronic infections, and presents tropism for particular organs in experimental infections. We evaluated T. Read More

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http://dx.doi.org/10.1016/j.exppara.2020.107931DOI Listing

CRISPR/Cas9-mediated metabolic pathway reprogramming in a novel humanized rat model ameliorates primary hyperoxaluria type 1.

Kidney Int 2020 May 25. Epub 2020 May 25.

Department of Pediatric Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 KongJiang Road, Shanghai, 200092, China; Children's Stone Treatment Center of National Health and Family Planning Commission of the People's Republic of China, 1665 KongJiang Road, Shanghai, 200092, China. Electronic address:

Primary hyperoxaluria type I is caused by mutations in the alanine glyoxylate aminotransferase gene (AGXT), leading to accumulation of glyoxylate and subsequent production of oxalate and urolithiasis. Here, we generated a novel rat model of primary hyperoxaluria type I that carries a D205N mutation in the partially humanized Agxt gene through the CRISPR/Cas9 system. The AgxtD205N mutant rats showed undetectable alanine glyoxylate aminotransferase protein expression, developed hyperoxaluria at 1 month of age and exhibited severe renal calcium oxalate deposition after ethylene glycol challenge. Read More

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http://dx.doi.org/10.1016/j.kint.2020.04.049DOI Listing

Immunoprotection against lethal effects of Crotalus durissus snake venom elicited by synthetic epitopes trapped in liposomes.

Int J Biol Macromol 2020 May 25. Epub 2020 May 25.

Departamento de Bioquímica e Imunologia, ICB, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, CEP: 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Snakebites caused by Crotalus genus are the second most frequent in Brazil. Crotoxin is a beta-neurotoxin responsible for the main envenomation effects of Crotalus biting, while crotamine immobilizes the animal hind limbs, contributing to prey immobilization and to envenoming symptoms. As crotoxin and crotamine represent about 90% of Crotalus venom dry weight, these toxins are of great importance for antivenom therapy. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.05.171DOI Listing

Vaccarin promotes proliferation of and milk synthesis in bovine mammary epithelial cells through the Prl receptor-PI3K signaling pathway.

Eur J Pharmacol 2020 May 25:173190. Epub 2020 May 25.

School of Animal Science, Yangtze University, Jingzhou, 434023, China. Electronic address:

Semen Vaccariae, the seed of Vaccaria segetalis, is traditionally used in East Asian countries for the treatment of breast milk deficiency, but the underlying molecular mechanism has not been discovered yet. The present study assessed the stimulatory effect of vaccarin, one of the major constituents of Semen Vaccariae, on proliferation of and milk synthesis in bovine mammary epithelial cells (BMECs) and explored the corresponding molecular mechanism. Vaccarin affected cell proliferation and milk fat and protein synthesis in a concentration-dependent manner, with the best stimulatory effects at 0. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173190DOI Listing

Sunlight and health: shifting the focus from vitamin D3 to photobiomodulation by red and near-infrared light.

Ageing Res Rev 2020 May 25:101089. Epub 2020 May 25.

Department of Public Health Solutions, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.

Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101089DOI Listing

An analytical workflow for seed-based correlation and independent component analysis in interventional resting-state fMRI studies.

Neurosci Res 2020 May 25. Epub 2020 May 25.

Centre for Microscopy, Characterisation and Analysis, Research Infrastructure Centres, The University of Western Australia, Perth, WA, Australia; School of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia. Electronic address:

Resting-state functional MRI (rs-fMRI) is a task-free method of detecting spatially distinct brain regions with correlated activity, which form organised networks known as resting-state networks (RSNs). The two most widely used methods for analysing RSN connectivity are seed-based correlation analysis (SCA) and independent component analysis (ICA) but there is no established workflow of the optimal combination of analytical steps and how to execute them. Rodent rs-fMRI data from our previous longitudinal brain stimulation studies were used to investigate these two methods using FSL. Read More

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http://dx.doi.org/10.1016/j.neures.2020.05.006DOI Listing

Neuroprotective effect of quercetin nanoparticles: A possible prophylactic and therapeutic role in alzheimer's disease.

J Chem Neuroanat 2020 May 25:101795. Epub 2020 May 25.

Department of Histology and Cell Biology, Minia University- Faculty of Medicine, Egypt.

Background: Alzheimer's disease (AD) is the most common cause of dementia in elderly. Quercetin is a well-known flavonoid with low bioavailability. Recently, quercetin nanoparticles (QNPs) has been shown to have a better bioavailability. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2020.101795DOI Listing

Construction and immunogenicity of a gE/gI/TK-deleted PRV based on porcine pseudorabies virus variant.

Mol Cell Probes 2020 May 25:101605. Epub 2020 May 25.

Zhengzhou Key Laboratory for Pig Disease Prevention and Control, College of Animal Science and Veterinary Medicine, Henan Agricultural University, Nongye Road 63#, Zhengzhou, 450002, Henan Province, People's Republic of China. Electronic address:

Pseudorabies (PR) caused by re-emerging pseudorabies virus (PRV) variant has outbroken among PRV vaccine-immunized swine herds on many Chinese pig farms, with severe socioeconomic consequences since late 2011. Here, a gE/gI/TK-deleted recombinant virus (rPRV NY-gE/gI/TK) was constructed based on PRV NY strain from 2012 through homologous DNA recombination and gene-editing technology termed clustered regularly interspaced palindromic repeats (CRISPR)/associated (Cas9) system. The rPRV NY-gE/gI/TK strain showed similar growth kinetics to the parental PRV NY strain in vitro, and was safe for mice. Read More

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http://dx.doi.org/10.1016/j.mcp.2020.101605DOI Listing

One-year chronic toxicity evaluation of single dose intravenously administered silica nanoparticles in mice and their Ex vivo human hemocompatibility.

J Control Release 2020 May 25. Epub 2020 May 25.

Utah Center for Nanomedicine, Nano Institute of Utah, and University of Utah, Salt Lake City, Utah, United States; Department of Pharmaceutics and Pharmaceutical Chemistry, Nano Institute of Utah, and University of Utah, Salt Lake City, Utah, United States; Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States. Electronic address:

Chronic toxicity evaluations of nanotechnology-based drugs are essential to support initiation of clinical trials. Ideally such evaluations should address the dosing strategy in human applications and provide sufficient information for long-term usage. Herein, we investigated one-year toxicity of non-surface modified silica nanoparticles (SNPs) with variations in size and porosity (Stöber SNPs 46 ± 4. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.05.027DOI Listing

Resveratrol protects the mitochondria from vitrification injury in mouse 2-cell embryos.

Cryobiology 2020 May 25. Epub 2020 May 25.

Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, China; College of Veterinary Medicine, Northwest A & F University, Yangling, Shaanxi, 712100, China. Electronic address:

Mitochondria play a key role in embryo development by providing energy. However, vitrification often causes mitochondrion damage of embryo, which further impairs embryo development. Therefore, the efficiency of embryo development after vitrification could be improved by protecting mitochondrial function from vitrification injury. Read More

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http://dx.doi.org/10.1016/j.cryobiol.2020.05.007DOI Listing

Deletion mutant of PGE receptor using CRISPR-Cas9 exhibits larval immunosuppression and adult infertility in a lepidopteran insect, Spodoptera exigua.

Dev Comp Immunol 2020 May 25:103743. Epub 2020 May 25.

Biological Control of Insect Research Laboratory, USDA/Agricultural Research Service, Colombia, MO, USA.

Prostaglandins (PGs) mediate various physiological processes in insects and other invertebrates, but there is very little information on PG receptors. This study identified a PGE receptor (SePGER) in the lepidopteran insect, Spodoptera exigua, and addressed its functional association with cellular immunity, development, and reproduction. SePGER is expressed in most developmental stages and tissues. Read More

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http://dx.doi.org/10.1016/j.dci.2020.103743DOI Listing

The N-glycans of lactoferrin: More than just a sweet decoration.

Biochem Cell Biol 2020 May 28. Epub 2020 May 28.

Leibniz Institute for Farm Animal Biology (FBN), Institute of Reproductive Biology , Wilhelm-Stahl-Allee 2 , Dummerstorf, Germany , 18196 ;

Nearly all extracellular proteins undergo posttranslational modification with sugar chains during their transit through the endoplasmic reticulum and the Golgi apparatus. These "sweet" modifications not only influence the activity of its carrier protein, but they themselves often have bioactivity, independent of the carrier function. Lactoferrin belongs to the group of glycoproteins and is modified with several different N-glycans. Read More

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http://dx.doi.org/10.1139/bcb-2020-0106DOI Listing

Platelet Concentrate Treatments for Temporomandibular Disorders: A Systematic Review and Meta-analysis.

JDR Clin Trans Res 2020 May 28:2380084420927326. Epub 2020 May 28.

Faculty of Dentistry, McGill University, Montreal, QC, Canada.

Objectives: This systematic review compared platelet concentrates (PCs) versus hyaluronic acid (HA) or saline/Ringer's solution injections as treatments of temporomandibular osteoarthritis and disc displacement in terms of pain and maximum mouth opening (MMO).

Methods: PubMed, Cochrane, and Scopus were searched up to March 6, 2020. Inclusion criteria were randomized clinical trials (RCTs). Read More

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http://dx.doi.org/10.1177/2380084420927326DOI Listing

Medicinal Mushroom, Grifola gargal (Agaricomycetes), Lowers Triglyceride in Animal Models of Obesity and Diabetes and in Adults with Prediabetes.

Int J Med Mushrooms 2020 ;22(1):79-91

Research Institute of Green Science and Technology, Shizuoka University, Shizuoka, Japan; Graduate School of Agriculture, Shizuoka University, Shizuoka, Japan; and Graduate School of Science and Technology, Shizuoka University, Japan.

Grifola gargal is a medicinal mushroom with biological effects, such as antiatherogenic activity, and is used as a treatment for various chronic inflammatory diseases. The aim of this study is to investigate the antidiabetic and antiobesity effects of a low-molecular weight hot water extract from G. gargal (GGL) against diabetes type 2. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019033285DOI Listing
January 2020

Effects of Substrates on the Production of Fruiting Bodies and the Bioactive Components by Different Cordyceps militaris Strains (Ascomycetes).

Int J Med Mushrooms 2020 ;22(1):55-63

College of Animal Science and Technology, Jilin Agricultural University, Xincheng Str. 2888, 130118, Changchun, China.

Cordyceps militaris is a type of food and medicinal species and is widely cultured in Asia. Substrate and strain are important factors for the production of fruiting bodies and bioactive components contents in fruiting bodies of C. militaris. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019033257DOI Listing
January 2020

BEVA primary care clinical guidelines: Wound Management in the Horse.

Equine Vet J 2020 May 28. Epub 2020 May 28.

Waikato Equine Veterinary Centre, Cambridge, New Zealand.

Background: There are currently no evidence summaries on wounds in the horse.

Objectives: To develop evidence-based guidelines on wound management in the horse. Study design Evidence review using the GRADE framework METHODS: Research questions were proposed by a panel of veterinarians, and developed into PICO format. Read More

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http://dx.doi.org/10.1111/evj.13289DOI Listing

Longitudinal Monitoring of Flow-Diverting Stent Tissue Coverage After Implant in a Bifurcation Model Using Neurovascular High-Frequency Optical Coherence Tomography.

Neurosurgery 2020 May 28. Epub 2020 May 28.

Department of Radiology, New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, Massachusetts.

Background: Tissue growth over covered branches is a leading cause of delayed thrombotic complications after flow-diverter stenting (FDS). Due to insufficient resolution, no imaging modality is clinically available to monitor this phenomenon.

Objective: To evaluate high-frequency optical coherence tomography (HF-OCT), a novel intravascular imaging modality designed for the cerebrovascular anatomy with a resolution approaching 10 microns, to monitor tissue growth over FDS in an arterial bifurcation model. Read More

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http://dx.doi.org/10.1093/neuros/nyaa208DOI Listing

Umai Dish Preparation Practices and Food Safety Behaviors in Bintulu Locals on Borneo Island, Malaysia.

J Food Prot 2020 May 28. Epub 2020 May 28.

Universiti Putra Malaysia.

Umai  is a popular, traditional, native dish of the Melanau ethnic group in Sarawak. It is prepared using thin slices of raw marine fish marinated with calamansi juice and seasoned with other ingredients. The local people believe that the acidity of the citrus juice along with the use of salt and spice, can slightly cook the fish and remove the fishy smell. Read More

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http://dx.doi.org/10.4315/JFP-19-543DOI Listing

Dilp-2-mediated PI3-kinase activation coordinates reactivation of quiescent neuroblasts with growth of their glial stem cell niche.

PLoS Biol 2020 May 28;18(5):e3000721. Epub 2020 May 28.

Department of Biology, University of Virginia, Charlottesville, Virginia, United States of America.

Dietary nutrients provide macromolecules necessary for organism growth and development. In response to animal feeding, evolutionarily conserved growth signaling pathways are activated, leading to increased rates of cell proliferation and tissue growth. It remains unclear how different cell types within developing tissues coordinate growth in response to dietary nutrients and whether coordinated growth of different cell types is necessary for proper tissue function. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000721DOI Listing

Antibiotic residues and antibiotic-resistant bacteria detected in milk marketed for human consumption in Kibera, Nairobi.

PLoS One 2020 28;15(5):e0233413. Epub 2020 May 28.

Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA, United States of America.

The use of veterinary antibiotics is largely unregulated in low-income countries. Consequently, food producers rarely observe drug withdrawal periods, contributing to drug residues in food products. Drug residues in milk can cause immunogenic reactions in people, and selectively favor antibiotic-resistant bacteria in unpasteurized products. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233413PLOS

Guinea worm in domestic dogs in Chad: A description and analysis of surveillance data.

PLoS Negl Trop Dis 2020 May 28;14(5):e0008207. Epub 2020 May 28.

Guinea Worm Eradication Program, The Carter Center, Atlanta, Georgia, United States of America.

After a ten-year absence of reported Guinea worm disease in Chad, human cases were rediscovered in 2010, and canine cases were first recorded in 2012. In response, active surveillance for Guinea worm in both humans and animals was re-initiated in 2012. As of 2018, the Chad Guinea Worm Eradication Program (CGWEP) maintains an extensive surveillance system that operates in 1,895 villages, and collects information about worms, hosts (animals and humans), and animal owners. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008207DOI Listing

Influence of human amylin on the membrane stability of rat primary hippocampal neurons.

Aging (Albany NY) 2020 May 28;12. Epub 2020 May 28.

Department of Pharmacology, Institution of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang, Hebei, China.

The two most common aging-related diseases, Alzheimer's disease and type 2 diabetes mellitus, are associated with accumulation of amyloid proteins (β-amyloid and amylin, respectively). This amylin aggregation is reportedly cytotoxic to neurons. We found that aggregation of human amylin (hAmylin) induced neuronal apoptosis without obvious microglial infiltration . Read More

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http://dx.doi.org/10.18632/aging.103105DOI Listing

Analytical challenges and perspectives of assessing viability of cysts and oocysts by live/dead simultaneous staining.

Environ Technol 2020 May 28:1-18. Epub 2020 May 28.

Department of Hydraulics and Sanitation, São Carlos School of Engineering, University of São Paulo, Avenida Trabalhador São-carlense 400, São Carlos, São Paulo 13566-590, Brazil.

and are pathogenic protozoa often present in the environment in their infective form(cysts and oocysts). These parasites are very resistant to disinfection, which makes them important target organisms in environmental quality monitoring and sanitation. Viability assessment provides an interpretation of cell inactivation, and it can be evaluated by membrane integrity as well as enzyme activity, usingdifferent staining methods. Read More

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http://dx.doi.org/10.1080/09593330.2020.1775712DOI Listing

[Prevalencia de leptospirosis en perros de trabajo vacunados y en población humana con riesgo ocupacional].

Biomedica 2020 May 1;40(Supl. 1):62-75. Epub 2020 May 1.

Grupo CIENVET, Departamento Salud Animal, Facultad de Ciencias Agropecuarias, Universidad de Caldas, Manizales, Colombia.

Introducción. Los perros de trabajo pueden infectarse con diversas serovariedades de Leptospira que se mantienen en sus túbulos renales e intersticios por mucho tiempo, por lo que se convierten en portadores y fuentes de infección para otros huéspedes. Objetivo. Read More

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http://dx.doi.org/10.7705/biomedica.5009DOI Listing

Assessment of Brix refractometry to estimate immunoglobulin G concentration in beef cow colostrum.

J Vet Intern Med 2020 May 28. Epub 2020 May 28.

Department of Production Animal Health, University of Calgary Faculty of Veterinary Medicine, Calgary, Alberta, Canada.

Background: Brix refractometry can be used to assess colostral immunoglobulin G (IgG) concentration, but studies identifying Brix percentages to detect high- and low-IgG colostrum are lacking for beef cows and interlaboratory agreement is unknown.

Objectives: Evaluate Brix refractometer performance and interlaboratory agreement for assessing beef cow colostrum IgG concentration, including determination of thresholds to identify colostrum containing IgG concentrations <100 g/L and ≥150 g/L.

Animals: Beef cows (n = 416) from 11 cow-calf operations in Alberta, Canada. Read More

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http://dx.doi.org/10.1111/jvim.15805DOI Listing

Design of a surrogate Anticalin® protein directed against CD98hc for preclinical studies in mice.

Protein Sci 2020 May 28. Epub 2020 May 28.

Lehrstuhl für Biologische Chemie, Technische Universität München, Freising, Germany.

The human CD98 heavy chain (CD98hc) offers a promising biomedical target both for tumor therapy and for drug delivery to the brain. We have previously developed a cognate Anticalin protein with picomolar affinity and demonstrated its effectiveness in a xenograft animal model. Due to the lack of cross-reactivity with the murine ortholog, we now report the development and X-ray structural analysis of an Anticalin with high affinity towards CD98hc from mouse. Read More

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http://dx.doi.org/10.1002/pro.3894DOI Listing

Evaluation of a 3-dimensional ultrasound device for noninvasive measurement of urinary bladder volume in dogs.

J Vet Intern Med 2020 May 28. Epub 2020 May 28.

Pax Imaging PLLC, Hayden, Idaho, USA.

Background: The BladderScan Prime Plus (BPP; Verathon, Bothell, Washington) is an application-specific, three-dimensional ultrasound device used for human, point-of-care volumetry of the urinary bladder.

Objective: To estimate the BPP's accuracy, repeatability, and optimized settings for assessing urinary bladder volumes in dogs, a variable utilized in assessing micturition disorders.

Animals: Twenty-four, client-owned, healthy, male dogs presenting for routine examination. Read More

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http://dx.doi.org/10.1111/jvim.15811DOI Listing

Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys.

J Vet Intern Med 2020 May 28. Epub 2020 May 28.

Department of Animal Medicine and Surgery, University of Cordoba, Campus Rabanales, Road Madrid-Cadiz km 396, 14104, Cordoba, Spain.

Background: Little information is available about endotoxemia in donkeys. Characterizing the systemic inflammatory response (SIRS) to lipopolysaccharide (LPS) in donkeys would provide valuable clinical and therapeutic information. The effects of meloxicam on endotoxemia have not been studied in this species. Read More

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http://dx.doi.org/10.1111/jvim.15783DOI Listing

Effect of proximal abducting ulnar osteotomy (PAUL) on frontal plane thoracic limb alignment: An ex vivo canine study.

Vet Surg 2020 May 28. Epub 2020 May 28.

Department of Small Animal Clinical Sciences, Texas A&M University, College Station, Texas, USA.

Objective: To determine the effect of proximal abducting ulnar osteotomy (PAUL) on frontal plane thoracic limb alignment in standing and recumbent positions.

Study Design: Ex vivo cadaveric study.

Sample Population: Canine thoracic limbs (n = 15 limb pairs). Read More

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http://dx.doi.org/10.1111/vsu.13425DOI Listing

Effects of Aerosol Insecticide Application Location on the Patterns of Residual Efficacy Against Tribolium confusum (Coleoptera: Tenebrionidae) Larvae.

J Econ Entomol 2020 May 28. Epub 2020 May 28.

Department of Entomology, Kansas State University, Manhattan, KS.

Aerosol insecticides are one tool that pest management professionals can utilize as a spatial treatment inside food facilities and storage warehouses. Methods of aerosol application can vary significantly and can affect the spatial pattern of efficacy achieved. We investigated how the location from which an aerosol insecticide is applied inside a mill influenced the spatial dispersal of the insecticide. Read More

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http://dx.doi.org/10.1093/jee/toaa103DOI Listing

Metatranscriptomic Characterization of COVID-19 Identified A Host Transcriptional Classifier Associated With Immune Signaling.

Clin Infect Dis 2020 May 28. Epub 2020 May 28.

Department of Infection Diseases, Huashan Hospital affiliated to Fudan University, Shanghai, China.

Background: The recent identification of a novel coronavirus, also known as SARS-CoV-2, has caused a global outbreak of respiratory illnesses. The rapidly developing pandemic has posed great challenges to diagnosis of this novel infection. However, little is known about the metatranscriptomic characteristics of patients with Coronavirus Disease 2019 (COVID-19). Read More

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http://dx.doi.org/10.1093/cid/ciaa663DOI Listing
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