6,807,185 results match your criteria Animal Nutrition And Feed Technology[Journal]

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Oxidative state in equine neonates: anti and pro-oxidants.

Equine Vet J 2020 Jun 3. Epub 2020 Jun 3.

Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, Prof. Orlando Marques de Paiva Avenue, 87, São Paulo, 05508-270, Brazil.

Background: In newborns, exposure to the extrauterine environment with high oxygen tension and sudden pulmonary adaptation lead to an increase in reactive oxygen species (ROS). ROS have several physiological roles, which are essential for neonatal development, however, when unbalanced, these highly unstable molecules can cause cellular destabilisation, compromising vital processes.

Objectives: To characterise the oxidative status in healthy equine neonates, evaluating an indicator of lipid peroxidation and both enzymatic and non-enzymatic antioxidant systems, during the first week of life. Read More

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http://dx.doi.org/10.1111/evj.13297DOI Listing

Differentiation between Cistus L. (Sub-) Species (Cistaceae) Using NMR Metabolic Fingerprinting.

Planta Med 2020 Jun 3. Epub 2020 Jun 3.

University of Innsbruck, Institute for Pharmacy/Department of Pharmacognosy, Center for Molecular Biosciences Innsbruck (CMBI), Innsbruck, Austria.

The genus is taxonomically complex, as taxonomic classification of individual species based on morphological criteria is often difficult and ambiguous. However, specific species contain valuable natural products, especially terpenoids and polyphenols, which exert various biological effects and might therefore be used for treatment of a broad array of disorders. Hence, a fast and reliable method for clear identification of different (sub-) species is required. Read More

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http://dx.doi.org/10.1055/a-1176-1937DOI Listing

Influenza infection has fiber type-specific effects on cellular and molecular skeletal muscle function in aged mice.

J Gerontol A Biol Sci Med Sci 2020 Jun 3. Epub 2020 Jun 3.

University of Massachusetts Amherst.

Skeletal muscle myopathies represent a common non-pulmonary manifestation of influenza infection, leading to reduced physical function and hospitalization in older adults. However, underlying mechanisms remain poorly understood. Our study examined the effects of influenza virus A pulmonary infection on contractile function at the cellular (single fiber) and molecular (myosin-actin interactions and myofilament properties) levels in soleus and extensor digitorum longus muscles of aged (20 months) C57BL/6 male mice that were healthy or flu infected for 7 (7-days post-infection; 7-DPI) or 12 days (12-DPI). Read More

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http://dx.doi.org/10.1093/gerona/glaa136DOI Listing

Testicular organoid formation is a property of immature somatic cells, which self-assemble and exhibit long-term hormone-responsive endocrine function.

Biofabrication 2020 Jun 3. Epub 2020 Jun 3.

OB/GYN, Northwestern University Feinberg School of Medicine, Chicago, Illinois, UNITED STATES.

Testicular organoid models are tools to study testicular physiology, development, and spermatogenesis. However, few side-by-side comparisons of organoid generation method have been evaluated. Here, we directly tested whether the culture microenvironment is the prime determinant promoting testicular organoid self-assembly. Read More

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http://dx.doi.org/10.1088/1758-5090/ab9907DOI Listing

Biological applications of a turn-on bioluminescent probe for monitoring sulfite oxidase deficiency in vivo.

Eur J Med Chem 2020 May 23;200:112476. Epub 2020 May 23.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong, 250012, China. Electronic address:

Sulfites are widely used as preservative and antioxidant additives in food and drug. A non-invasive method for in vivo imaging of sulfite represents a powerful tool for estimating its potential effects in living organisms. Herein, we report the design, development, and application of sulfite bioluminescent probes (SBPs) for the analyte-specific detection of sulfite through sulfite-mediated intramolecular cleavage. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112476DOI Listing

IgE sensitivity to Malassezia pachydermatis and mite allergens in dogs with atopic dermatitis.

Vet Immunol Immunopathol 2020 May 21;226:110070. Epub 2020 May 21.

Department of Veterinary Microbiology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan. Electronic address:

In this study, dogs with atopic dermatitis were separated into non-food-induced atopic dermatitis (NFIAD) group (n = 15) and food-induced atopic dermatitis (FIAD) group (n = 37) based on an elimination diet test. IgE reactivity for crude Malassezia pachydermatis (M. pachydermatis) and house dust mites (HDM) allergen extracts was investigated in the two groups using fluorometric enzyme-linked immunosorbent assay (ELISA) and intradermal skin test (IDST). Read More

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http://dx.doi.org/10.1016/j.vetimm.2020.110070DOI Listing

Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?

Med Hypotheses 2020 May 18;143:109843. Epub 2020 May 18.

Faculty of Medicine of University of Colombo, Kynsey Road, Colombo 00800, Sri Lanka. Electronic address:

SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109843DOI Listing

Photothermal/sonodynamic therapy of melanoma tumor by a gold/manganese dioxide nanocomposite: In vitro and in vivo studies.

Photodiagnosis Photodyn Ther 2020 May 31:101846. Epub 2020 May 31.

Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Nanosized materials have favorable applications in nanomedicine including photothermal therapy (PTT) and sonodynamic therapy (SDT) of most malignancies. Since conventional methods of cancer treatment encounter some limitations to this serious disorder, development of efficient routes is quite necessary. In this study, a gold/manganese dioxide nanocomposite (Au/MnO NC) was synthesized as a novel photo- and sono- responsive nanomaterial that was activated upon laser light of 808-nm wavelength irradiation or ultrasound exposure for cancer treatment applications. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101846DOI Listing

Effect of bee venom on reproductive performance and immune response of male rabbits.

Physiol Behav 2020 May 31:112987. Epub 2020 May 31.

Animal Production Research Institute, Agriculture Research Center, Egypt.

The current study aimed to investigate the effects of injecting bucks with different doses of bee venom (BV) on reproductive performance and immune response during the summer season. Forty-eight male V-line rabbits were randomly distributed among four homogeneous groups (12 bucks each). Three groups were injected BV under the neck skin with 0. Read More

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http://dx.doi.org/10.1016/j.physbeh.2020.112987DOI Listing

Amelioration of muscular spasm-induced pain of Guangtongxiao recipe in a non-everted gut sac in vitro model.

J Ethnopharmacol 2020 May 31:113040. Epub 2020 May 31.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.

Background: The modern study of the traditional Chinese medicine (TCM) compound recipes is a complex issue because of the large number of components in the recipes that would produce several metabolites after entering the body. The TCM compound recipes are known to have the advantage of synergistic treatment by multiple targets due to diverse components. Therefore, a research method that can reflect the overall effect of compounds with multi-components is essential. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113040DOI Listing

Ethnobotany, phytochemistry and pharmacological significance of the genus Bulbine (Asphodelaceae).

J Ethnopharmacol 2020 May 31:112986. Epub 2020 May 31.

Department of Agriculture and Animal Health, University of South Africa, Florida Campus, Florida, 1710, South Africa. Electronic address:

Ethnopharmacological Relevance: The genus Bulbine (Asphodelaceae) is spread across Southern Africa and Australia and has been traditionally used for various medicinal applications such as treating skin diseases, burns, diarrhoea, and sexually transmitted diseases.

Aim Of This Review: The aim is to present a critical review of the ethnomedicinally important species of the genus Bulbine with a comprehensive overview of their chemical constituents and biological activities.

Materials And Methods: This paper is an overview of literature published on the genus Bulbine in the last six decades with regards to phytochemical composition and their respective pharmacological potentials with the aid of data obtained from the search engine Google Scholar with string searches performed using keywords to obtain relevant publications from scientific databases including ACS Journals, PubMed, Science Direct, SciELO, Sci Finder, Springer, Tailor & Francis, The Plant List Database, Web of Science and Wiley. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112986DOI Listing

Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis.

Pharmacol Res 2020 May 31:104981. Epub 2020 May 31.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China. Electronic address:

Tumor initiation and progression are not only ascribed to the behavior of cancer cells, but also profoundly influenced by the tumor microenvironment. Inside, cancer-associated fibroblasts (CAFs) have become key factors to accelerate growth and metastasis for the abundance in most solid tumors. Our group previously reported that Oroxylin A (OA), a flavone from Scutellaria Baicalensis Georgi, possess the ability to suppress growth and invasion of several tumor cells. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104981DOI Listing

Designing neuroreparative strategies using aged regenerating animal models.

Ageing Res Rev 2020 May 31:101086. Epub 2020 May 31.

Laboratory of Neural Circuit Development and Regeneration, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Leuven, Belgium. Electronic address:

In our ever-aging world population, the risk of age-related neuropathies has been increasing, representing both a social and economic burden to society. Since the ability to regenerate in the adult mammalian central nervous system is very limited, brain trauma and neurodegeneration are often permanent. As a consequence, novel scientific challenges have emerged and many research efforts currently focus on triggering repair in the damaged or diseased brain. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101086DOI Listing

A recombinase polymerase amplification combined with lateral flow dipstick for rapid and specific detection of African swine fever virus.

J Virol Methods 2020 May 31:113885. Epub 2020 May 31.

Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, Sichuan, PR China. Electronic address:

African swine fever (ASF) is an acute, hemorrhagic, highly contagious disease caused by African swine fever virus (ASFV) infection of domestic pigs and wild boars, showing mortality rates up to 100 %. There are no effective vaccines or antiviral drugs available for ASFV. Therefore, disease control is mainly based on animal slaughtering and the enforcement of strict sanitary measures. Read More

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http://dx.doi.org/10.1016/j.jviromet.2020.113885DOI Listing

Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells.

Cell Rep 2020 Jun;31(9):107711

Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219-3110, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address:

The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a bioengineered human liver derived from induced pluripotent stem cells (iPSCs) has not been previously described. By improving methods for liver decellularization, recellularization, and differentiation of different liver cellular lineages of human iPSCs in an organ-like environment, we generated functional engineered human mini livers and performed transplantation in a rat model. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107711DOI Listing

Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer.

Cell Rep 2020 Jun;31(9):107701

Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA; Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Bioengineering, Rice University, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer progression remain to be fully understood. While altered glucose metabolism in CAFs could fuel cancer cells, how such metabolic reprogramming emerges and is sustained needs further investigation. Studying fibroblasts isolated from patients with benign breast tissues and breast cancer, in conjunction with multiple animal models, we demonstrate that CAFs exhibit a metabolic shift toward lactate and pyruvate production and fuel biosynthetic pathways of cancer cells. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107701DOI Listing

Illuminating Genetic Mysteries of the Dead Sea Scrolls.

Cell 2020 May 15. Epub 2020 May 15.

Department of Neurobiology, George Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel. Electronic address:

The discovery of the 2,000-year-old Dead Sea Scrolls had an incomparable impact on the historical understanding of Judaism and Christianity. "Piecing together" scroll fragments is like solving jigsaw puzzles with an unknown number of missing parts. We used the fact that most scrolls are made from animal skins to "fingerprint" pieces based on DNA sequences. Read More

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http://dx.doi.org/10.1016/j.cell.2020.04.046DOI Listing

Cell-Penetrating Anti-Protein Kinase C Theta Antibodies Act Intracellularly to Generate Stable, Highly Suppressive Regulatory T Cells.

Mol Ther 2020 May 23. Epub 2020 May 23.

Graduate Program in Molecular and Cellular Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA; Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA. Electronic address:

Regulatory T cells maintain immunological tolerance and dampen inflammatory responses. Administering regulatory T cells can prevent the immune-mediated tissue destruction of graft-versus-host disease, which frequently accompanies hematopoietic stem cell transfer. Neutralizing the T cell-specific kinase, protein kinase C theta, which promotes T cell effector functions and represses regulatory T cell differentiation, augments regulatory T cell immunosuppression and stability. Read More

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http://dx.doi.org/10.1016/j.ymthe.2020.05.020DOI Listing

Evaluation of two lipid removal methods for stable carbon and nitrogen isotope analysis in whale tissue.

Rapid Commun Mass Spectrom 2020 Jun 3. Epub 2020 Jun 3.

Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, USA.

Rationale: The presence of lipids in animal tissues can influence the interpretation of stable isotope data, particularly in lipid-rich tissues such as the skin and muscle of marine mammals. The traditionally employed chloroform:methanol delipidation protocol has the potential to alter δ N values in proteinaceous tissues. Our objective was to determine whether cyclohexane is an alternative extraction method, effectively removing lipids without altering δ N values. Read More

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http://dx.doi.org/10.1002/rcm.8851DOI Listing

T2* mapping in an equine articular groove model - visualizing changes in collagen orientation.

J Orthop Res 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.

T2* mapping is promising for the evaluation of articular cartilage collagen. In this work, a groove model in a large animal is used as a model for post-traumatic arthritis. We hypothesized that T2* mapping could be employed to differentiate between healthy and (subtly) damaged cartilage. Read More

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http://dx.doi.org/10.1002/jor.24764DOI Listing

Reawakening of ancestral dental potential as a mechanism to explain dental pathologies.

Integr Comp Biol 2020 Jun 3. Epub 2020 Jun 3.

Institute of Experimental Medicine, Czech Academy of Sciences, Videnska 1083, Prague 4, Czech Republic.

During evolution there has been a trend to reduce both the number of teeth and the location where they are found within the oral cavity. In mammals the formation of teeth is restricted to a horseshoe band of odontogenic tissue, creating a single dental arch on the top and bottom of the jaw. Additional teeth and structures containing dental tissue, such as odontogenic tumours or cysts, can appear as pathologies. Read More

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http://dx.doi.org/10.1093/icb/icaa053DOI Listing

Electroretinogram of the Cone-Dominant Thirteen-Lined Ground Squirrel during Euthermia and Hibernation in Comparison with the Rod-Dominant Brown Norway Rat.

Invest Ophthalmol Vis Sci 2020 Jun;61(6)

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Purpose: The majority of small animal species used in research are nocturnal, with retinae that are anatomically and functionally dissimilar from humans, complicating their use as disease models. Herein we characterize the retinal structure and electrophysiological function of the diurnal, cone-dominant 13-lined ground squirrel (13-LGS) retina during euthermia and in hibernation.

Methods: Full-field electroretinography (ERG) was performed in 13-LGS and Brown Norway (BN) rat models to establish baseline values for retinal function in each species, including following intravitreal injection of pharmacologic agents to selectively block the contributions of ON- and OFF-bipolar cells. Read More

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http://dx.doi.org/10.1167/iovs.61.6.6DOI Listing

A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure.

PLoS One 2020 3;15(6):e0233007. Epub 2020 Jun 3.

Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, England, United Kingdom.

Background: In humans, stillbirth describes the death of a fetus before birth after 28 weeks gestation, and accounts for approximately 2.6 million deaths worldwide annually. In high-income countries, up to half of stillbirths have an unknown cause and are described as "unexplained stillbirths"; this lack of understanding impairs efforts to prevent stillbirth. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233007PLOS

The effect of early burn injury on sensitivity to future painful stimuli in dairy heifers.

PLoS One 2020 3;15(6):e0233711. Epub 2020 Jun 3.

Center for Animal Welfare, Department of Animal Science, University of California, Davis, California, United States of America.

Animals that experience painful procedures as neonates are more sensitive to pain later in life. We evaluated whether disbudding with a heated iron at 3 (n = 12), 35 (n = 9), or 56 (n = 20) d of age affected heifers' pain responses to vaccine injections at 11 mo of age. Heifers responded to the injection procedure with struggling and changes in eye temperature and heart rate variability compared to a sham procedure the day before, and still had a heightened response 6 d later, regardless of disbudding age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233711PLOS

Transcriptional activities of human elongation factor-1α and cytomegalovirus promoter in transgenic dogs generated by somatic cell nuclear transfer.

PLoS One 2020 3;15(6):e0233784. Epub 2020 Jun 3.

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seongbuk-gu, Seoul, Republic of Korea.

Recent advances in somatic cell nuclear transfer (SCNT) in canines facilitate the production of canine transgenic models. Owing to the importance of stable and strong promoter activity in transgenic animals, we tested human elongation factor 1α (hEF1α) and cytomegalovirus (CMV) promoter sequences in SCNT transgenic dogs. After transfection, transgenic donor fibroblasts with the hEF1α-enhanced green fluorescence protein (EGFP) transgene were successfully isolated using fluorescence-activated cell sorting (FACS). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233784PLOS

Cecal microbiome composition and metabolic function in probiotic treated broilers.

PLoS One 2020 3;15(6):e0225921. Epub 2020 Jun 3.

Department of Animal Sciences, The Ohio State University, Columbus, Ohio, United States of America.

Probiotics have become increasingly popular in the poultry industry as a promising nutritional intervention to promote the modulation of intestinal microbial communities and their metabolic activities as a means of improving health and performance. This study aimed to determine the influence of different probiotic formulations on the taxonomic and metabolic profiling of cecal microbial communities, as well as to define associations between cecal microbiota and growth parameters in 21 and 42-day-old broilers. Probiotics investigated included a synbiotic (SYNBIO), a yeast-based probiotic (YEAST), and three single-strain formulations of spore-forming Bacillus amyloliquefaciens (SINGLE1), B. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225921PLOS

Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.

PLoS Negl Trop Dis 2020 Jun 3;14(6):e0008364. Epub 2020 Jun 3.

School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom.

Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is one of the most widespread medically important arboviruses, causing human infections that result in mortality rates of up to 60%. We describe the selection of a high-affinity small protein (Affimer-NP) that binds specifically to the nucleoprotein (NP) of CCHFV. We demonstrate the interference of Affimer-NP in the RNA-binding function of CCHFV NP using fluorescence anisotropy, and its inhibitory effects on CCHFV gene expression in mammalian cells using a mini-genome system. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008364DOI Listing

[Structure of Neuroglobin from Cold-Water Sponge Halisarca dujardinii].

Mol Biol (Mosk) 2020 May-Jun;54(3):474-479

Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334 Russia.

The iron-containing protein neuroglobin (Ngb) involved in the transport of oxygen is generally considered the precursor of all animal globins. In this report, we studied the structure of Ngb of the cold-water sponge Halisarca dujardinii. In sponges, the oldest multicellular organisms, the Ngb gene contains three introns. Read More

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http://dx.doi.org/10.31857/S0026898420030039DOI Listing
October 2019

High-intensity focused ultrasound ablation of muscle in an anticoagulated swine model.

Minim Invasive Ther Allied Technol 2020 Jun 3:1-5. Epub 2020 Jun 3.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Image-guided non-invasive high-intensity focused ultrasound (HIFU) has been gaining recognition in treating musculoskeletal tumors and desmoids. However, there is no consensus on the appropriate perioperative management for patients on ongoing anticoagulation who undergo HIFU ablation. Image-guided HIFU treatment was performed in swine on an ongoing oral anticoagulation protocol ( = 5) in two treatment sessions seven days apart. Read More

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http://dx.doi.org/10.1080/13645706.2020.1760301DOI Listing

Pituitary adenylate cyclase activating polypeptide concentrations in the sheep mammary gland, milk, and in the lamb blood plasma after suckling.

Physiol Int 2020 Mar;107(1):92-105

6Institute of Animal Science, Faculty of the Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.

Pituitary adenylate cyclase activating polypeptide (PACAP) is involved in development and reproduction. We previously described elevated PACAP levels in the milk compared to the plasma, and the presence of its specific PAC1 receptor in the mammary gland. This study aimed to determine PACAP and vasoactive intestinal peptide (VIP) levels in female suckling lambs compared to ewe plasma and mammary gland, as well as their age-dependent alterations. Read More

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http://dx.doi.org/10.1556/2060.2020.00006DOI Listing

Applied anatomy and clinical significance of the maxillofacial and mandibular regions of the barking deer (Muntiacus muntjak) and sambar deer (Rusa unicolor).

Folia Morphol (Warsz) 2020 Jun 3. Epub 2020 Jun 3.

Department of Animal Genetics and Breeding, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (I), Selesih, Aizawl, Mizoram, India.

There is no previously reported information on the applied anatomy and clinical significance of the maxillofacial and mandibular regions of the barking deer and sambar deer. Therefore, the present study was designed to provide some important clinical landmarks related to tracking of the infraorbital, mental and mandibular nerves with its clinical implications in regional anaesthesia in both the species. In the present study, the distance between the most lateral bulging of the facial tuberosity to the infraorbital foramen and from the latter to the root of the alveolar tooth directly ventral to it was found to be 2. Read More

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http://dx.doi.org/10.5603/FM.a2020.0061DOI Listing

A historical review of the techniques of recovery of parasites for their detection in human stools.

Rev Soc Bras Med Trop 2020 1;53:e20190535. Epub 2020 Jun 1.

Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.

Since the early 20th century, the detection of intestinal parasites has improved with the development of several techniques for parasitic structures recovery and identification, which differ in sensitivity, specificity, practicality, cost, and infrastructure demand. This study aims to review, in chronological order, the stool examination techniques and discuss their advantages, limitations, and perspectives, and to provide professionals and specialists in this field with data that lays a foundation for critical analysis on the use of such procedures. The concentration procedures that constitute the main techniques applied in routine research and in parasitological kits are a) spontaneous sedimentation; b) centrifugation-sedimentation with formalin-ethyl acetate; and c) flotation with zinc sulfate solution. Read More

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http://dx.doi.org/10.1590/0037-8682-0535-2019DOI Listing

Community ecology of the metazoan parasites of the Atlantic thread herring, Opisthonema oglinum (Lesueur, 1818) (Actinopterygii: Clupeidae) from the Sepetiba Bay, Rio de Janeiro, Brazil.

Authors:
L Chaves F Paschoal

Braz J Biol 2020 May 29. Epub 2020 May 29.

Laboratório de Parasitologia Animal, Centro de Pesquisas em Biologia, Universidade Castelo Branco, Rio de Janeiro, RJ, Brasil.

This study aimed to evaluate the parasitic fauna of Opisthonema oglinum (Lesueur, 1818) from Southeastern Brazil. Between September 2017 and March 2018, a total of 100 specimens of O. oglinum from the Sepetiba Bay, Rio de Janeiro, Brazil (22°54'S, 43°34'W) were examined. Read More

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http://dx.doi.org/10.1590/1519-6984.229814DOI Listing

BPA toxicity during development of zebrafish embryo.

Braz J Biol 2020 May 20. Epub 2020 May 20.

Programa de Pós-graduação em Ciências Aplicadas à Saúde, Laboratório de Genética e Biologia Molecular, Universidade Federal de Goiás, Jataí, GO, Brasil.

Bisphenol A (BPA) is a monomer used in the production of polycarbonate, a polymer commonly found in plastics, epoxy resins and thermal papers. The presence of BPA in food, water, air and dust has been of great concern in recent years not only due to environmental and ecological issues but also because of its supposed risk to public health related to its mutagenic and carcinogenic potential. In this study we evaluated the toxicity of bisphenol A in zebrafish embryos (Danio rerio) and determined the 50% lethal concentration (LC50) of this chemical. Read More

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http://dx.doi.org/10.1590/1519-6984.230562DOI Listing

Change in malate dehydrogenase and alpha amylase activities in Rubus fruticosus and Valeriana jatamansi treated granary weevil, Sitophilus granarius.

Braz J Biol 2020 Jun 1. Epub 2020 Jun 1.

Department of Biological Science, Karakoram International University, Gilgit Baltistan, Pakistan.

Poor storage conditions provide favorable environment to stored grain pests for their growth. The bio-pesticides are the best alternatives to synthetic pesticides. Present study was conducted to compare toxicity of Rubus fruticosus and Valeriana jatamansi against granary weevil, Sitophilus granarius and subsequent changes in enzyme activity responsible for grain damage. Read More

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http://dx.doi.org/10.1590/1519-6984.226952DOI Listing

application of carbonic anhydrase to accelerate the equilibration of O between HO and CO for the rapid measurement of O/O isotope ratios in aqueous samples.

Isotopes Environ Health Stud 2020 Jun 3:1-10. Epub 2020 Jun 3.

Institute of Nutritional Physiology "Oskar Kellner", Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany.

A novel method of the accelerated equilibration of O between CO and HO for the measurement of the O/O isotope ratios in aqueous samples with natural isotope abundances is presented. This rapid equilibrium method is based on the application of the enzyme carbonic anhydrase (CA). The CA from bovine erythrocytes was adsorptively fixed to 3-mm glass beads with an etched surface. Read More

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http://dx.doi.org/10.1080/10256016.2020.1772253DOI Listing

Development and Evaluation of Motion-activated System for Improved Chest Drainage: Bench, In Vivo Results, and Pilot Clinical Use of Technology.

Surg Innov 2020 Jun 3:1553350620927579. Epub 2020 Jun 3.

R1 Engineering , OH, USA.

. The aim of this study was to evaluate a motion-activated system (MAS) that applies motion-activated energy (vibration) to prevent chest tube clogging and maintain tube patency. We performed chest tube blood flow analysis in vitro, studied MAS effects on intraluminal clot deposition in vivo, and conducted a pilot clinical test. Read More

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http://dx.doi.org/10.1177/1553350620927579DOI Listing

Development of a Man-probe-based multiplex real-time PCR for the simultaneous detection of emerging and reemerging swine coronaviruses.

Virulence 2020 Jan;11(1):707-718

MOE Joint International Research Laboratory of Animal Health and Food Safety, Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing, China.

With the outbreak of the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, coronaviruses have become a global research hotspot in the field of virology. Coronaviruses mainly cause respiratory and digestive tract diseases, several coronaviruses are responsible for porcine diarrhea, such as porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and emerging swine acute diarrhea syndrome coronavirus (SADS-CoV). Those viruses have caused huge economic losses and are considered as potential public health threats. Read More

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http://dx.doi.org/10.1080/21505594.2020.1771980DOI Listing
January 2020

Harnessing Nerve-Muscle Cell Interactions for Biomaterials-based Skeletal Muscle Regeneration.

J Biomed Mater Res A 2020 Jun 3. Epub 2020 Jun 3.

Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, Indiana.

Nerve cells secrete neurotrophic factors that play a critical role in neuronal survival, proliferation and regeneration. However, their role in regulating myoblast behavior and skeletal muscle repair remains largely unexplored. In the present study, we investigated the effects of PC12 secreted signaling factors in modulating C2C12 myoblast behavior in physiologically relevant conditions. Read More

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http://dx.doi.org/10.1002/jbm.a.37022DOI Listing

Drug-loading three-dimensional scaffolds based on hydroxyapatite-sodium alginate for bone regeneration.

J Biomed Mater Res A 2020 Jun 3. Epub 2020 Jun 3.

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.

Bone tissue engineering is a promising approach for tackling clinical challenges. Osteoprogenitor cells, osteogenic factors, and osteoinductive/osteoconductive scaffolds are employed in bone tissue engineering. However, scaffold materials remain limited due to their source, low biocompatibility and so on. Read More

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http://dx.doi.org/10.1002/jbm.a.37018DOI Listing

Mechanical interplay between cell shape and actin cytoskeleton organization.

Soft Matter 2020 Jun 3. Epub 2020 Jun 3.

Instituut-Lorentz, Leiden University, P.O. Box 9506, 2300 RA Leiden, The Netherlands.

We investigate the mechanical interplay between the spatial organization of the actin cytoskeleton and the shape of animal cells adhering on micropillar arrays. Using a combination of analytical work, computer simulations and in vitro experiments, we demonstrate that the orientation of the stress fibers strongly influences the geometry of the cell edge. In the presence of a uniformly aligned cytoskeleton, the cell edge can be well approximated by elliptical arcs, whose eccentricity reflects the degree of anisotropy of the cell's internal stresses. Read More

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http://dx.doi.org/10.1039/d0sm00492hDOI Listing

Nanobodies derived from Camelids represent versatile biomolecules for biomedical applications.

Biomater Sci 2020 Jun 3. Epub 2020 Jun 3.

Center for Global Health, School of Public Health, Nanjing Medical University, 211166 Nanjing, China. and Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University, Nanjing 211166, China and The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, 211166 Nanjing, China.

Nanobodies are antigen binding variable domains of heavy-chain antibodies without light-chains, and these biomolecules occur naturally in the serum of Camelidae species. Nanobodies have a compact structure and low molecular weight when compared with antibodies, and are the smallest active antigen-binding fragments. Because of their remarkable stability and manipulable characteristics, nanobodies have been incorporated into biomaterials and used as molecular recognition and tracing agents, drug delivery systems, molecular imaging tools and disease therapeutics. Read More

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http://dx.doi.org/10.1039/d0bm00574fDOI Listing

Type, Timing, and Diversity of Complementary Foods Among Native Hawaiian, Pacific Islander, and Filipino Infants.

Hawaii J Health Soc Welf 2020 May;79(5 Suppl 1):127-134

Nutrition Support Shared Resource, University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, HI (CJB).

Prevention is the recommended strategy for addressing childhood obesity and may be particularly important for minority groups such as Native Hawaiians, Pacific Islanders, and Filipinos (NHPIF) who display poorer health outcomes than other race/ethnic groups. Complementary feeding is a critical milestone in the first 1,000 days of life and plays a critical role in growth and eating habit formation. This cross-sectional study recruited NHPIF infants between 3 - 12 months of age residing on O'ahu, Hawai'i to examine timing and types of complementary foods introduced first as well as the dietary diversity of those infants 6 - 12 months of age. Read More

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Keiki Produce Prescription (KPRx) Program Feasibility Study to Reduce Food Insecurity and Obesity Risk.

Hawaii J Health Soc Welf 2020 May;79(5 Suppl 1):44-49

Wai'anae Coast Comprehensive Health Center, Wai'anae HI (AH, MH, MO).

One in 6 US children experience food insecurity, signifying that at some time during the last year their household did not have sufficient food, money, or resources to feed their family. These children experience little intake of fresh fruits and vegetables (FV), a risk factor for chronic disease, including obesity. Produce prescription programs provide vouchers to purchase fresh FV at participating retailers. Read More

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The impact of scavenging: perspective from casework in forensic anthropology.

Forensic Sci Res 2020 9;5(1):32-37. Epub 2020 Feb 9.

Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC, USA.

Forensic anthropology casework frequently encounters evidence of animal scavenging associated with fragmentation and loss of skeletal material. Published research demonstrates that patterns of destruction in bone can suggest the size and type of animal involved. This study analyzes 107 cases reported on by the first author at the Smithsonian Institution to investigate patterns of scavenging in forensic anthropology casework. Read More

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http://dx.doi.org/10.1080/20961790.2019.1704473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241500PMC
February 2020

Adjuvant activity of -derived mycolic acids.

Heliyon 2020 May 27;6(5):e04064. Epub 2020 May 27.

Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, 849-8501, Japan.

Successful vaccination, especially with safe vaccines such as component/subunit vaccines, requires proper activation of innate immunity and, for this purpose, adjuvant is used. For clinical use, alum is frequently used while, for experimental use, CFA, containing Mycobacterial components, was often used. In this report, we demonstrated that mycolic acids (MA), major and essential lipid components of the bacterial cell wall of the genus , has adjuvant activity. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260583PMC

Parity and season affect hematological, biochemical, and milk parameters during the early postpartum period in grazing dairy cows from high-tropics herds.

Heliyon 2020 May 26;6(5):e04049. Epub 2020 May 26.

One Health & Veterinary Research and Innovative Development Group - OHVRI, School of Veterinary Medicine, Faculty of Agrarian Sciences, University of Antioquia, Medellin, Colombia.

Improving the early detection of animals or herds at increased risk for diseases, reduced milk yield or impaired reproductive performance should be an essential component of herd health programs. The present study aimed to describe the findings of hematological, biochemical, and milk analytes of grazing cows from tropical dairy herds during the early postpartum period, and the effects of parity and calving season. In the North of Antioquia, Colombia which is the major area of specialized dairy production in the country, a longitudinal study comprising 260 dairy cows selected at calving, was conducted. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256465PMC
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