6,562,689 results match your criteria Animal Nutrition And Feed Technology[Journal]

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Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar Dynein function in primary cilia.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

St. Vincent's Institute of Medical Research.

Mutations in subunits of the cilia-specific cytoplasmic Dynein-2 (CD2) complex cause short-rib thoracic dystrophy syndromes (SRTDs), characterized by impaired bone growth and life-threatening perinatal respiratory complications. Different SRTD mutations result in varying disease severities. It remains unresolved whether this reflects the extent of retained hypomorphic protein functions or relative importance of the affected subunits for the activity of the CD2 holoenzyme. Read More

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http://dx.doi.org/10.1093/hmg/ddz083DOI Listing

CIDR estrous synchronization in the Arabian Oryx (Oryx leucoryx).

Theriogenology 2019 Apr 15;132:113-117. Epub 2019 Apr 15.

Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Egypt; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, King Faisal University, Saudi Arabia.

In Jordan, the Arabian Oryx (Oryx leucoryx) is considered among the most important wild ungulates. The Arabian Oryx is listed as vulnerable species according to the International Union for Conservation of Nature (IUCN). Based on author's knowledge, estrus synchronization in the Arabian Oryx has never been investigated. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.04.017DOI Listing

Degradation of bisphenol a using peroxymonosulfate activated by WO@MoS/Ag hollow nanotubes photocatalyst.

Chemosphere 2019 Apr 16;227:589-597. Epub 2019 Apr 16.

Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, 4888 Shengbei Rd, Changchun, 130102, China. Electronic address:

WO@MoS/Ag (HW@MA) hollow tubes were successfully engineered to photodegrade bisphenol A (BPA) combined with peroxymonosulfate (PMS) for the first time. XRD, XPS, TEM and SEM were conducted. The HW@MA tubes present excellent photocatalytic performance on the removal of BPA. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.067DOI Listing
April 2019
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Inhibitory effects of sildenafil and tadalafil on inflammation, oxidative stress and nitrosative stress in animal model of bronchial asthma.

Pharmacol Rep 2019 Feb 15;71(3):517-521. Epub 2019 Feb 15.

Vallabhbhai Patel Chest Institute, New Delhi, India.

Background: Cyclic neucleotides are involved in many cellular functions including smooth muscle relaxation, inflammation, and signal transduction. Sildenafil and tadalafil are phosphodiesterase-5 (PDE-5) inhibitors which prevent the degradation of cyclic neucleotide i.e. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.008DOI Listing
February 2019

Copper nanoparticles modify the blood plasma antioxidant status and modulate the vascular mechanisms with nitric oxide and prostanoids involved in Wistar rats.

Pharmacol Rep 2019 Feb 15;71(3):509-516. Epub 2019 Feb 15.

Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.

Background: We aimed to analyze whether a diet supplemented with a standard dose of copper (Cu) in the form of nanoparticles, as an alternative to carbonate, exerts beneficial effects within the vasculature and improves the blood antioxidant status.

Methods: Male Wistar rats were fed for 8 weeks with a diet supplemented with Cu (6.5 mg Cu/kg in the diet) either as nanoparticles (40 nm diameter) or carbonate - the control group. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.007DOI Listing
February 2019

CRAC channels and disease - From human CRAC channelopathies and animal models to novel drugs.

Authors:
Stefan Feske

Cell Calcium 2019 Mar 11;80:112-116. Epub 2019 Mar 11.

Department of Pathology, New York University School of Medicine, New York, NY, 10016, USA. Electronic address:

Ca release-activated Ca (CRAC) channels are intimately linked with health and disease. The gene encoding the CRAC channel, ORAI1, was discovered in part by genetic analysis of patients with abolished CRAC channel function. And patients with autosomal recessive loss-of-function (LOF) mutations in ORAI1 and its activator stromal interaction molecule 1 (STIM1) that abolish CRAC channel function and store-operated Ca entry (SOCE) define essential functions of CRAC channels in health and disease. Read More

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http://dx.doi.org/10.1016/j.ceca.2019.03.004DOI Listing

The value of manure - Manure as co-product in life cycle assessment.

J Environ Manage 2019 Apr 19;241:293-304. Epub 2019 Apr 19.

Innovation Center for U.S. Dairy, USA.

Livestock production is important for food security, nutrition, and landscape maintenance, but it is associated with several environmental impacts. To assess the risk and benefits arising from livestock production, transparent and robust indicators are required, such as those offered by life cycle assessment. A central question in such approaches is how environmental burden is allocated to livestock products and to manure that is re-used for agricultural production. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.03.059DOI Listing

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection.

Microbes Infect 2019 Apr 19. Epub 2019 Apr 19.

Illawarra Health and Medical Research Institute and School of Chemistry and Molecular Bioscience, Molecular Horizons, University of Wollongong, Wollongong, New South Wales, Australia. Electronic address:

Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA mice compared to AlbPLG1 mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12864579193005
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http://dx.doi.org/10.1016/j.micinf.2019.04.004DOI Listing
April 2019
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Origin and evolution of core components responsible for monitoring light environment changes during plant terrestrialization.

Mol Plant 2019 Apr 19. Epub 2019 Apr 19.

School of Advanced Agriculture Sciences and School of Life Sciences, State Key Laboratory of Protein and Plant Gene Research, Peking University, Beijing 100871, China. Electronic address:

Light serves as the source of energy as well as information signals for photosynthetic plants. During evolution, plants have acquired the ability to monitor environmental light radiation and adjust their developmental patterns to optimally utilize light energy for photosynthesis. The mechanisms of light perception and signal transduction have been comprehensively studied in the past decades, mostly in a few model plants, including Arabidopsis thaliana. Read More

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http://dx.doi.org/10.1016/j.molp.2019.04.006DOI Listing

Genetic status of indigenous poultry (red jungle fowl) from India.

Gene 2019 Apr 19. Epub 2019 Apr 19.

Department of Biotechnology, Assam University, Silchar, Assam Pin-788011, India; University of Kalyani, Nadia, West Bengal Pin-741235, India. Electronic address:

The global biodiversity of domesticated red jungle fowl (Gallus gallus) is gradually eroding by replacement with commercial poultry breeds and results loss of valuable genetic and physical traits like resistance to disease, extreme environment, etc. posing a threat to the poultry genetic resources. Very fewer reports exist on Indian poultry diversity, especially native chicken of India. Read More

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http://dx.doi.org/10.1016/j.gene.2019.04.051DOI Listing

Medium optimization and characterization of cell culture system from Penaeus vannamei for adaptation of white spot syndrome virus (WSSV).

J Virol Methods 2019 Apr 19. Epub 2019 Apr 19.

Aquatic animal health and environment division, ICAR-Central Institute of Brackishwater Aquaculture, #75, Santhome High Road, Raja Annamalaipuram; Chennai, Tamil Nadu, 600028, India. Electronic address:

The lack of shrimp cell lines and difficulty in establishing shrimp cell culture systems, with an appropriate medium is a major concern in the aquaculture sector. The present study attempts to address this issue by developing an in vitro cell culture system from various tissues (hemocytes, heart, lymphoid tissue, hepatopancreas, gill, eye stalk, and muscle) of Penaeus vannamei (P.vannamei) using commercially available L-15 medium. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.04.016DOI Listing

Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition.

Behav Brain Res 2019 Apr 19:111921. Epub 2019 Apr 19.

Johns Hopkins University (JHU), Department of Anesthesiology and Critical Care Medicine, Baltimore, MD, United States. Electronic address:

Neonatal brain injury from hypoxia-ischemia (HI) causes major morbidity. Piglet HI is an established method for testing neuroprotective treatments in large, gyrencephalic brain. Though many neurobehavior tests exist for rodents, such tests and their associations with neuropathologic injury remain underdeveloped and underutilized in large, neonatal HI animal models. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111921DOI Listing

A path to cooperation between China and Mongolia towards the control of echinococcosis under the Belt and Road Initiative.

Acta Trop 2019 Apr 19. Epub 2019 Apr 19.

London School of Hygiene and Tropical Medicine, United Kingdom.

Health is the core of development. Health cooperation between countries plays a pivotal role under the 'Belt and Road' Initiative. In 2013, China launched its Belt and Road Initiative to improve the international cooperation of which health was an important component. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183108
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http://dx.doi.org/10.1016/j.actatropica.2019.04.022DOI Listing
April 2019
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Tissue Clearing and Its Application to Bone and Dental Tissues.

J Dent Res 2019 Apr 22:22034519844510. Epub 2019 Apr 22.

1 Department of Restorative Sciences, School of Dentistry, Texas A&M University, Dallas, TX, USA.

Opaqueness of animal tissue can be attributed mostly to light absorption and light scattering. In most noncleared tissue samples, confocal images can be acquired at no more than a 100-µm depth. Tissue-clearing techniques have emerged in recent years in the neuroscience field. Read More

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http://dx.doi.org/10.1177/0022034519844510DOI Listing

Social preferences for ecosystem services in a biodiversity hotspot in South America.

PLoS One 2019 22;14(4):e0215715. Epub 2019 Apr 22.

Department of Ecology, Social-Ecological Systems Laboratory, Universidad Autónoma de Madrid, Madrid, Spain.

Identifying which ecosystem services are relevant to different stakeholders and understanding stakeholders' perceptions of such services is useful for making informed decisions, especially in regions of the world where the achievement of biodiversity conservation goals is threatened by economically productive activities. In this article, we assess social preferences for ecosystem services in a biodiversity hotspot in central Chile. We use a consultative case study to ask local stakeholders (n = 70) from the Campana Peñuelas Biosphere Reserve to identify the most important ecosystem services the area provides for them and inquire about the perceived vulnerability of the services to changes in the future. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215715PLOS

Energy partitioning in cattle fed diets based on tropical forage with the inclusion of antibiotic additives.

PLoS One 2019 22;14(4):e0211565. Epub 2019 Apr 22.

Department of Animal Sciences, Veterinary School, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil, Pampulha.

The aim of this study was to describe energy partitioning in dairy crossbreed bulls fed tropical forage-based diets supplemented with different additives. Twenty F1 crossbred bulls (Holstein x Gyr) with initial and final live weight (LW) averages of 190 ± 17 and 275 ± 20 kg were fed sorghum (Sorghum bicolour) and Tanzania grass (Panicum maximum cv. Tanzania) silage (70:30 DM basis) with supplemented concentrate at a forage to concentrate ratio of 50:50. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211565PLOS

Fatty acid-binding protein 1 increases steer fat deposition by facilitating the synthesis and secretion of triacylglycerol in liver.

PLoS One 2019 22;14(4):e0214144. Epub 2019 Apr 22.

College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, China.

Castration is an important means of improving the beef quality via increasing fat deposition. However, little is known about the molecular mechanism underlying the fat deposition after castration. Here, the intramuscular fat (IMF) content of the steer group was shown to be much higher than the bull group. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214144PLOS

Assessment on reticuloendotheliosis virus infection in specific-pathogen-free chickens based on detection of yolk antibody.

PLoS One 2019 22;14(4):e0213978. Epub 2019 Apr 22.

College of Veterinary Medicine, Shandong Agricultural University, Taian, China.

Reticuloendotheliosis virus (REV) is the most frequent exogenous virus that contaminates attenuated vaccines. Therefore, it is extremely important to select REV-free specific-pathogen-free (SPF) chicken embryos. Generally, REV infection is assessed by detecting REV antibodies in SPF chickens. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213978PLOS

Anti-interferon-α receptor 1 antibodies attenuate inflammation and organ injury following hemorrhagic shock.

J Trauma Acute Care Surg 2019 May;86(5):881-890

From the Elmezzi Graduate School of Molecular Medicine, (J.C., W-L.Y., P.W.); Center for Immunology and Inflammation, (J.C., W-L.Y., Z.W., P.W.) The Feinstein Institute for Medical Research, Manhasset; Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, (W-L.Y., J.T.M., P.W.) Hempstead, New York.

Background: Hemorrhagic shock (HS) is a life-threatening condition resulting from rapid and significant loss of intravascular volume, leading to hemodynamic instability and death. Inflammation contributes to the multiple organ injury in HS. Type I interferons (IFNs), such as IFN-α and IFN-β, are a family of cytokines that regulate the inflammatory response through binding to IFN-α receptor (IFNAR) which consists of IFNAR1 and IFNAR2 chains. Read More

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http://dx.doi.org/10.1097/TA.0000000000002214DOI Listing

Towards a neurobiological understanding of pain in neurofibromatosis type 1: mechanisms and implications for treatment.

Pain 2019 May;160(5):1007-1018

Departments of Pharmacology and.

Neurofibromatosis type 1 (NF1) is the most common of a group of rare diseases known by the term, "Neurofibromatosis," affecting 1 in 3000 to 4000 people. NF1 patients present with, among other disease complications, café au lait patches, skin fold freckling, Lisch nodules, orthopedic complications, cutaneous neurofibromas, malignant peripheral nerve sheath tumors, cognitive impairment, and chronic pain. Although NF1 patients inevitably express pain as a debilitating symptom of the disease, not much is known about its manifestation in the NF1 disease, with most current information coming from sporadic case reports. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001486DOI Listing

Recombinant Expression of Zinc Transporter SLC39A6 and Its Functional Antibody Production.

Monoclon Antib Immunodiagn Immunother 2019 Apr;38(2):70-74

1 Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran.

Zinc transporter ZIP6 (SLC39A6) or LIV-1 is a protein that belongs to a subfamily of proteins group that displays structural specifications of zinc transporters in the cell membrane. Overexpression of this protein is observed in breast, prostate, and kidney tumor cells. Lately, LIV-1 is a dependable marker for detection of estrogen receptor positive breast cancer, which can be used to detect luminal breast cancer type A. Read More

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http://dx.doi.org/10.1089/mab.2018.0045DOI Listing

Analyses of Livestock-Associated Pan-Genomes Suggest Virulence Is Not Primary Interest in Evolution of Its Genome.

OMICS 2019 Apr;23(4):224-236

1 Department of Animal Behaviour & Physiology, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, India.

is not only part of normal flora but also an opportunistic pathogen relevant to microbial genomics, public health, and veterinary medicine. In addition to being a well-known human pathogen, causes various infections in economically important livestock animals such as cows, sheep, goats, and pigs. There are very few studies that have examined the pan-genome of or the host-specific strains' pan-genomes. Read More

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http://dx.doi.org/10.1089/omi.2019.0005DOI Listing

Characterization of Plasmid-Mediated Quinolone Resistance in Gram-Negative Bacterial Strains from Animals and Humans in China.

Microb Drug Resist 2019 Apr 22. Epub 2019 Apr 22.

Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, P.R. China.

The aim of this study was to determine the molecular epidemiology of plasmid-mediated quinolone resistance (PMQR) determinants in , ( spp.), , and Four hundred seventy-two nonrepetitive isolates were collected from different sources in China and screened for the presence of PMQR genes (PMQRs). Then, 49 PMQR producers were selected to study the coexistence of PMQRs and other resistance genes using whole-genome sequencing (WGS). Read More

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https://www.liebertpub.com/doi/10.1089/mdr.2018.0405
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http://dx.doi.org/10.1089/mdr.2018.0405DOI Listing
April 2019
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PARTIAL PROTECTION IN BALB/C HOUSE MICE () AND ROCKY MOUNTAIN ELK () AFTER VACCINATION WITH A KILLED, MUCOSALLY DELIVERED VACCINE.

J Wildl Dis 2019 Apr 22. Epub 2019 Apr 22.

2   Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.

Brucellosis, caused by , has been eliminated from livestock in the US. Remaining wildlife reservoirs are the bison () and elk () populations in Yellowstone National Park and the surrounding area, from which there is periodic exposure and transmission to surrounding livestock herds. Elk account for nearly all of the livestock exposure, and the infection appears to be expanding in the elk population. Read More

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QUANTIFYING THE SEVERITY OF GIRAFFE SKIN DISEASE VIA PHOTOGRAMMETRY ANALYSIS OF CAMERA TRAP DATA.

J Wildl Dis 2019 Apr 22. Epub 2019 Apr 22.

1   Research on the Ecology of Carnivores and Their Prey Laboratory, Department of Fisheries and Wildlife, Michigan State University, 480 Wilson Road, 13 Natural Resources Building, East Lansing, Michigan 48824, USA.

Developing techniques to quantify the spread and severity of diseases afflicting wildlife populations is important for disease ecology, animal ecology, and conservation. Giraffes () are in the midst of a dramatic decline, but it is not known whether disease is playing an important role in the broad-scale population reductions. A skin disorder referred to as giraffe skin disease (GSD) was recorded in 1995 in one giraffe population in Uganda. Read More

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Oral Capillariosis Due to in Migrating Sharp-shinned Hawks () in New York, USA, 2016-18.

J Wildl Dis 2019 Apr 22. Epub 2019 Apr 22.

2 Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, 240 Farrier Road, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.

Oral lesions focused around the oral commissures were documented in several Sharp-shinned Hawks () in the 2016-18 spring migration season at a banding station located on the southern shore of Lake Ontario, New York. Samples of the inflamed and caseous lesions repeatedly tested negative for and poxvirus; however, large numbers of capillariid eggs and embedded worms were consistently present. Morphologically, the nematodes were identified as , which was confirmed by PCR and genetic sequencing. Read More

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in Bats from Hubei Province, China, 2018.

J Wildl Dis 2019 Apr 22. Epub 2019 Apr 22.

1 School of Health Sciences, and State Key Laboratory of Virology, Wuhan University, Wuhan 430071, China.

To understand the potential role of bats in the epidemiology of , we investigated the frequency of in bats from Central China in 2018. Sixty bats belonging to four species of two families were captured from rural areas of Xianning City, Hubei Province, China. We extracted DNA from the kidneys of bats, and spp. Read More

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Evaluation of a Human Virtual-Reality Endoscopy Trainer for Teaching Early Endoscopy Skills to Veterinarians.

J Vet Med Educ 2019 Apr 22:1-11. Epub 2019 Apr 22.

Competency in flexible endoscopy is a major goal of small animal internal medicine residency training programs. Hands-on laboratories to teach entry-level skills have traditionally used anesthetized laboratory dogs (live dog laboratory [LDL]). Virtual-reality endoscopy trainers (VRET) are used for this purpose in human medicine with the clear benefits of avoiding live animal use, decreasing trainee stress, and allowing repeated, independent training sessions. Read More

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http://dx.doi.org/10.3138/jvme.0418-037rDOI Listing

Comparison of the Moral Sensitivity, Judgment, and Actions of Australian and Turkish Veterinary Students in Relation to Animal Ethics Issues.

J Vet Med Educ 2019 Apr 22:1-10. Epub 2019 Apr 22.

Veterinarians regularly face animal ethics conflicts, and research has identified the moral reasoning methods that they utilize to solve these. It is unclear whether students' sensitivity to animal ethics conflicts influences their reasoning methods, and the recent development of appropriate tests allows this to be assessed. We compared the moral reasoning methods, intended action and sensitivity of 112 first-year veterinary students in two contrasting veterinary schools, in Australia and Turkey. Read More

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http://dx.doi.org/10.3138/jvme.1117-178r1DOI Listing

The Effect of Ovariohysterectomy Model Practice on Surgical Times for Final-Year Veterinary Students' First Live-Animal Ovariohysterectomies.

J Vet Med Educ 2019 Apr 22:1-12. Epub 2019 Apr 22.

This study evaluated whether one supervised simulated ovariohysterectomy (OVH) using a locally developed canine OVH model, decreased surgical time for final-year veterinary students' first live-animal OVH. We also investigated student perceptions of the model as a teaching aid. Final-year veterinary students were exposed to an OVH model (Group M, = 48) and compared to students without the exposure (Group C, = 58). Read More

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http://dx.doi.org/10.3138/jvme.1217-181r1DOI Listing

Veterinary Behavior: Assessment of Veterinarians' Training, Experience, and Comfort Level with Cases.

J Vet Med Educ 2019 Apr 22:1-12. Epub 2019 Apr 22.

Studies of US animal shelters consistently indicate that behavior is often a major reason for relinquishment and, thereby, euthanasia of millions of dogs and cats annually. Even though this is an area in which veterinarians can intervene to support the human-animal bond, prior research has documented that they frequently do not bring the topic up during appointments. This study explored veterinarians' training in animal behavior and behavioral medicine, along with their level of comfort in treating common behavioral problems. Read More

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http://dx.doi.org/10.3138/jvme.0318-035r1DOI Listing
April 2019
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Guidelines for Implementing a Low-Cost Volunteer Desexing Skills Training Program for Veterinary and Veterinary Technology Students.

J Vet Med Educ 2019 Apr 22:1-13. Epub 2019 Apr 22.

Although desexing surgeries are considered a core clinical skill for small animal veterinary practice, it can be challenging for veterinary schools to provide students with adequate training opportunities in the traditional curriculum. At the Massey University School of Veterinary Science, we recently established an innovative extracurricular volunteer program designed to have students teaching other students how to perform different elements of desexing procedures as they progress through their degree. This program includes administrative and assistant roles for first-year students (responsible for client communication, patient restraint, and medical record keeping), physical exam and recovery roles for second-year students (responsible for assessing patient fitness for surgery, drawing up anesthetic drugs, and monitoring patients in recovery), anesthesia and neuter surgeon roles for third-year students (responsible for inducing, preparing, and monitoring spay patients and performing cat neuter surgeries), and spay surgeon roles for fourth- and fifth-year students (responsible for performing cat spay surgeries, discharging patients, and following up with clients to monitor recovery). Read More

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http://dx.doi.org/10.3138/jvme.0418-047r1DOI Listing

Development and Validation of a Canine Castration Model and Rubric.

J Vet Med Educ 2019 Apr 22:1-13. Epub 2019 Apr 22.

Veterinary educators use models to allow repetitive practice of surgical skills leading to clinical competence. Canine castration is a commonly performed procedure that is considered a Day One competency for a veterinarian. In this study, we sought to create and evaluate a canine pre-scrotal closed castration model and grading rubric using a validation framework of content evidence, internal structure evidence, and relationship with other variables. Read More

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http://dx.doi.org/10.3138/jvme.1117-158r1DOI Listing

Effect of Knockout Serum Replacement During Postwarming Recovery Culture on the Development and Quality of Vitrified Parthenogenetic Porcine Blastocysts.

Biopreserv Biobank 2019 Apr 19. Epub 2019 Apr 19.

1 Yunnan Provincial Engineering Laboratory of Animal Genetic Resource Conservation and Germplasm Enhancement, Yunnan Animal Science and Veterinary Institute, Kunming, P.R. China.

The postwarming recovery culture, as one of the steps in cryopreservation process, is directly correlated with the survival and quality of embryos. Generally, recovery medium includes undefined serum or serum components that may cause the instability of results and other problems. The objective of this study was to evaluate the effect of knockout serum replacement (KSR) as a substitute for serum during recovery culture on the development and quality of vitrified parthenogenetic porcine blastocysts. Read More

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http://dx.doi.org/10.1089/bio.2018.0132DOI Listing

Antibacterial Effects of Phytic Acid against Foodborne Pathogens and Investigation of Its Mode of Action.

J Food Prot 2019 Apr 22:826-833. Epub 2019 Apr 22.

1 Laboratory of Food Microbiology, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, People's Republic of China (ORCID: https://orcid.org/0000-0003-4483-1386 [Q.Z.]).

This study investigated the antimicrobial mechanism of phytic acid (PA) and its antibacterial effects in combination with ethanol. The MIC of PA on ATCC 11229, ATCC 6538P, ATCC 6633, and Typhimurium CICC 27483 were 0.24, 0. Read More

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http://jfoodprotection.org/doi/10.4315/0362-028X.JFP-18-418
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http://dx.doi.org/10.4315/0362-028X.JFP-18-418DOI Listing
April 2019
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CARBOSILANE DENDRONS-PEPTIDES NANOCONJUGATES AS ANTIMICROBIAL AGENTS.

Mol Pharm 2019 Apr 22. Epub 2019 Apr 22.

Over last decades, multidrug resistant bacteria have emerged and spread, increasing the number of bacteria against which, commonly used antibiotics are no longer effective. It has become a serious public health problem whose solution requires medical research in order to explore novel effective antimicrobial molecules. On one hand, antimicrobial peptides (AMPs) are regarded as a good alternative due to their generally broad-spectrum activities, but sometimes they can be easily degraded by the organism or be toxic to animal cells. Read More

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http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00222
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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00222DOI Listing
April 2019
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Eudesmane Glycosides from Ambrosia artemisiifolia (Common Ragweed) as Potential Neuroprotective Agents.

J Nat Prod 2019 Apr 22. Epub 2019 Apr 22.

Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.

In Alzheimer's disease, amyloid-β (Aβ) accumulation in the brain results in neuronal cell death and is one of the major causes of dementia. Because the current therapeutic agents are not yet sufficiently effective or safe, there have been attempts to find new neuroprotective chemicals against Aβ-induced cytotoxicity. A 70% EtOH extract of whole plants of Ambrosia artemisiifolia (common ragweed) was selected after the screening of a natural extract library. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b00841DOI Listing

Cholix toxin, an eEF2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes.

Cell Microbiol 2019 Apr 22:e13033. Epub 2019 Apr 22.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Vibrio cholerae produced-Cholix toxin (Cholix) is a cytotoxin that ADP-ribosylates eukaryotic elongation factor 2, inhibiting protein synthesis, and inducing apoptosis. Here, we identified prohibitin (PHB) 1 and 2 as novel Cholix-interacting membrane proteins in immortalized human hepatocytes and HepG2 cells by Cholix immunoprecipitation assays. The expression level of PHB1 was decreased by Cholix after a 12 h incubation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13033
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http://dx.doi.org/10.1111/cmi.13033DOI Listing
April 2019
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Fate of Mycobacterium avium subsp. paratuberculosis and changes in bacterial diversity populations in dairy slurry after chemical treatments.

J Appl Microbiol 2019 Apr 22. Epub 2019 Apr 22.

Instituto de Medicina Preventiva Veterinaria.

Aims: A major drawback of using dairy slurry as fertilizer is that it may contains pathogens such as Mycobacterium avium subsp. paratuberculosis (MAP), and it could represent a risk to animal and public health. Thus, the aim of this study was to evaluate the fate of MAP and bacterial communities in dairy slurry after chemical treatments. Read More

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http://dx.doi.org/10.1111/jam.14288DOI Listing

Effects of pulsed inhaled nitric oxide on arterial oxygenation during mechanical ventilation in anaesthetised horses undergoing elective arthroscopy or emergency colic surgery.

Equine Vet J 2019 Apr 22. Epub 2019 Apr 22.

Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Background: Administration of pulsed inhaled nitric oxide (PiNO) improves arterial oxygenation in spontaneously breathing anaesthetised healthy horses and in horses undergoing colic surgery. However, because hypoventilation commonly occurs, horses are often mechanically ventilated to prevent hypercarbia.

Objectives: To evaluate the effects of PiNO on arterial oxygenation during anaesthesia in mechanically ventilated healthy horses and horses undergoing colic surgery. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/evj.13129
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http://dx.doi.org/10.1111/evj.13129DOI Listing
April 2019
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Technical Note: The first live treatment on a 1.0 Tesla inline MRI-linac.

Med Phys 2019 Apr 22. Epub 2019 Apr 22.

University of Sydney, ACRF ImageX Institute, Sydney Medical School, Australia.

Purpose: This work describes the first live imaging and radiation delivery performed on a prototype 1.0 Tesla inline MRI-Linac system in a rat brain tumour model, which was conducted on 29 January 2019.

Methods: A human scale 1. Read More

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http://dx.doi.org/10.1002/mp.13556DOI Listing

Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry.

J Vis Exp 2019 Apr 3(146). Epub 2019 Apr 3.

Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago;

Imaging mass spectrometry (IMS) has routinely been applied to three types of samples: tissue sections, spheroids, and microbial colonies. These sample types have been analyzed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) to visualize the distribution of proteins, lipids, and metabolites across the biological sample of interest. We have developed a novel sample preparation method that combines the strengths of the three previous applications to address an underexplored approach for identifying chemical communication in cancer, by seeding mammalian cell cultures into agarose in coculture with healthy tissues followed by desiccation of the sample. Read More

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http://dx.doi.org/10.3791/59490DOI Listing

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns).

J Vis Exp 2019 Apr 6(146). Epub 2019 Apr 6.

Univ. Bordeaux UMR INTERTRYP 177 IRD CIRAD; IRD UMR 177 INTERTRYP CIRAD; Centre Hospitalier Université Bordeaux;

This method allows the separation of trypanosomes, parasites responsible for animal and human African trypanosomiasis (HAT), from infected blood. This is the best method for diagnosis of first stage HAT and furthermore this parasite purification method permits serological and research investigations. HAT is caused by Tsetse fly transmitted Trypanosoma brucei gambiense and T. Read More

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http://dx.doi.org/10.3791/58415DOI Listing

Behavioral Tracking and Neuromast Imaging of Mexican Cavefish.

J Vis Exp 2019 Apr 6(146). Epub 2019 Apr 6.

Department of Biology, University of Hawai'i at Mānoa;

Cave-dwelling animals have evolved a series of morphological and behavioral traits to adapt to their perpetually dark and food-sparse environments. Among these traits, foraging behavior is one of the useful windows into functional advantages of behavioral trait evolution. Presented herein are updated methods for analyzing vibration attraction behavior (VAB: an adaptive foraging behavior) and imaging of associated mechanosensors of cave-adapted tetra, Astyanax mexicanus. Read More

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http://dx.doi.org/10.3791/59099DOI Listing

"Effectiveness of retrobulbar hyaluronidase injection in an iatrogenic blindness rabbit model using hyaluronic acid filler injection".

Plast Reconstr Surg 2019 Apr 15. Epub 2019 Apr 15.

Dept. of Plastic and Reconstructive Surgery, Cheil General Hospital and Women's Healthcare center, Dankook University, College of Medicine, South Korea.

Background: Blindness caused by soft tissue filler injection is the most tragic complication, with no standard treatments until recently. Retrobulbar hyaluronidase injection has been proposed as the treatment, but its effectiveness in visual compromise remains to be determined. The authors aimed to determine the effectiveness of retrobulbar hyaluronidase using soft tissue filler in an iatrogenic blindness animal model. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005716DOI Listing
April 2019
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Structure-function relationships in peripheral nerve contributions to diabetic peripheral neuropathy.

Pain 2019 May;160 Suppl 1:S29-S36

Department of Molecular Pharmacology, Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.

Diabetes mellitus (DM) is a major global health concern, affecting more than 9% of the world population. The most common complication of DM is diabetic peripheral neuropathy (DPN), which leads to neuropathic pain in as many as 50% of patients. Despite its prevalence, there is neither good prevention of nor treatments for DPN, representing a major gap in care for the many who are afflicted. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001530DOI Listing

Translational neuropathic pain research.

Pain 2019 May;160 Suppl 1:S23-S28

INSERM U987, Ambroise Paré Hospital, APHP, Boulogne-Billancourt, France.

The traditional translational approach in neuropathic pain research has mainly consisted to date in translating basic findings from animal models of nerve injury to the clinic. Because of the difficulty to extrapolate mechanisms from animals to humans, an inverse translational approach ("top-down") has been advocated and contributed to the development of therapy. In particular, a number of treatments such as neurostimulation techniques have been initially assessed in patients and then translated to animal models for further investigation of their mechanisms. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001522DOI Listing

Neuropathic itch.

Pain 2019 May;160 Suppl 1:S11-S16

Department of Experimental Pain Research, CBTM Mannheim, Heidelberg University, Mannheim, Germany.

Neuropathic itch is clinically important but has received much less attention as compared to neuropathic pain. In the past decade, itch-specific pathways have been characterized on a cellular and molecular level, but their exact role in the pathophysiology of neuropathic itch is still unclear. Traditionally, mutually exclusive theories for itch such as labeled line, temporal/spatial pattern, or intensity theory have been proposed, and experimental studies in mice mainly favor the specificity theory of itch. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001551DOI Listing

Current state of urethral tissue engineering.

Curr Opin Urol 2019 Apr 16. Epub 2019 Apr 16.

Sheffield Teaching Hospitals, Department of Female, Functional and Reconstructive Urology, Royal Hallamshire Hospital, Sheffield.

Purpose Of Review: Urethrotomy remains the first-line therapy in the treatment of a urethral stricture despite data showing no real chance of a cure after repeated urethroplasties. An anastomotic or an augmentation urethroplasty with oral mucosa should be offered to patients with a failed urethrotomy. The availability of grafts can be a concern for both patients and surgeons. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000637DOI Listing

Stem-cell regenerative medicine as applied to the penis.

Curr Opin Urol 2019 Apr 16. Epub 2019 Apr 16.

Department of Urology.

Purpose Of Review: Tissue engineering and regenerative medicine has emerged as a new scientific interdisciplinary field focusing on developing new strategies to repair or recreate tissues and organs. This review gathers findings on erectile dysfunction and, Peyronie's disease from recent preclinical and clinical studies under heading of stem-cell regenerative medicine.

Recent Findings: Over the last 2 years, preclinical studies on rat models demonstrated the tangible beneficial role of stem cells and stromal vascular fraction in the context of preventing fibrosis and restoring erectile function in different animal models of Erectile dysfunction and Peyronie's disease. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000636DOI Listing
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