4,043 results match your criteria Animal Genetics[Journal]


Genome-wide association studies reveal genetic loci associated with plasma cholinesterase activity in ducks.

Anim Genet 2019 Apr 17. Epub 2019 Apr 17.

Key Laboratory of Animal (Poultry) Genetics Breeding and Reproduction, Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.

Plasma cholinesterase (PCHE) activity is an important auxiliary test in human clinical medicine. It can distinguish liver diseases from non-liver diseases and help detect organophosphorus poisoning. Animal experiments have confirmed that PCHE activity is associated with obesity and hypertension and changes with physiological changes in an animal's body. Read More

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http://dx.doi.org/10.1111/age.12791DOI Listing

Genome-wide association analysis and gene set enrichment analysis with SNP data identify genes associated with 305-day milk yield in Holstein dairy cows.

Anim Genet 2019 Apr 17. Epub 2019 Apr 17.

Department of Animal Sciences, Center for Reproductive Biology, Washington State University, PO Box 646310, Pullman, WA, 99164-6310, USA.

Milk production traits, such as 305-day milk yield (305MY), have been under direct selection to improve production in dairy cows. Over the past 50 years, the average milk yield has nearly doubled, and over 56% of the increase is attributable to genetic improvement. As such, additional improvements in milk yield are still possible as new loci are identified. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/age.12792
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http://dx.doi.org/10.1111/age.12792DOI Listing
April 2019
1 Read

Genome-wide association studies for milk production traits in Valle del Belice sheep using repeated measures.

Anim Genet 2019 Apr 14. Epub 2019 Apr 14.

Dipartimento Scienze Agrarie, Alimentari e Forestali, University of Palermo, 90128, Palermo, Italy.

Genome-wide association studies (GWASes) have become a powerful tool for identifying genomic regions associated with important traits in livestock. Milk production traits in dairy sheep are measured at different time points during their life span. Using phenotypic data generated from longitudinal traits could improve the power of association studies but until now have received less attention in GWASes as a methodology and has not been implemented. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/age.12789
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http://dx.doi.org/10.1111/age.12789DOI Listing
April 2019
4 Reads

Genome-wide identification and comparison of mRNAs, lncRNAs and circRNAs in porcine intramuscular, subcutaneous, retroperitoneal and mesenteric adipose tissues.

Anim Genet 2019 Apr 14. Epub 2019 Apr 14.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.

Many types of RNAs, including messenger RNAs (mRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), play crucial roles in regulating fat cell differentiation and tissue development. However, the expression profiles of these RNAs in different adipose tissues are still largely unknown. To shed light on this issue, we performed a transcriptome analysis of mRNAs, lncRNAs and circRNAs obtained from intramuscular adipose tissue, subcutaneous adipose tissue, retroperitoneal adipose tissue and mesenteric adipose tissue of Chinese Erhualian pigs. Read More

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http://dx.doi.org/10.1111/age.12781DOI Listing

Validation of SNP associations with bovine ovulation and twinning rate.

Anim Genet 2019 Apr 12. Epub 2019 Apr 12.

Roman L. Hruska U.S. Meat Animal Research Center (USMARC), United States Department of Agriculture, Agricultural Research Service (USDA, ARS), Clay Center, NE, 68933, USA.

Previous work identified SNP associations with twinning rate in the US Holstein population and developed a model for genomic prediction. The current study was conducted to assess the association of these SNPs with twinning rate and ovulation rate in a genetically diverse, outbred population selected for twinning and ovulation rate. A total of 18 SNPs that were components of a prediction equation for twinning rate in Holstein cattle were genotyped on 731 animals from the USDA Meat Animal Research Center production efficiency or twinning population. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/age.12793
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http://dx.doi.org/10.1111/age.12793DOI Listing
April 2019
3 Reads

Two insertion/deletion variants in the promoter region of the QPCTL gene are significantly associated with body weight and carcass traits in chickens.

Anim Genet 2019 Apr 11. Epub 2019 Apr 11.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China.

Glutaminyl-peptide cyclotransferase-like (QPCTL) is an isoenzyme of glutaminyl-peptide cyclotransferase (QPCT). QPCTL and QPCT catalyze the formation of N-terminal modified pyroglutamate-fractalkine and the chemokine CCL2. The objective of this study was to investigate the association between insertions/deletions in the chicken QPCTL promoter region with growth traits in chickens. Read More

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http://dx.doi.org/10.1111/age.12741DOI Listing

Explicit evidence for a missense mutation in exon 4 of SLC45A2 gene causing the pearl coat dilution in horses.

Anim Genet 2019 Apr 10. Epub 2019 Apr 10.

Departamento de Producción Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, 28040, Spain.

Four loci seem responsible for the dilution of the basic coat colours in horse: Dun (D), Silver Dapple (Z), Champagne (CH) and Cream (C). Apart from the current phenotypes ascribed to these loci, pearl has been described as yet another diluted coat colour in this species. To date, this coat colour seems to segregate only in the Iberian breeds Purebred Spanish horse and Lusitano and has also been described in breeds of Iberian origin, such as Quarter Horses and Paint Horse, where it is referred to as the 'Barlink Factor'. Read More

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http://dx.doi.org/10.1111/age.12784DOI Listing

Using genotyping-by-sequencing to predict gender in animals.

Anim Genet 2019 Apr 7. Epub 2019 Apr 7.

Invermay Agricultural Centre, AgResearch, Private Bag 50034, Mosgiel, 9053, New Zealand.

Gender assignment errors are common in some animal species and lead to inaccuracies in downstream analyses. Procedures for detecting gender misassignment are available for array-based SNP data but are still being developed for genotyping-by-sequencing (GBS) data. In this study, we describe a method for using GBS data to predict gender using X and Y chromosomal SNPs. Read More

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http://dx.doi.org/10.1111/age.12782DOI Listing

Genome-wide association study for body weight in cattle populations from Siberia.

Anim Genet 2019 Apr 7. Epub 2019 Apr 7.

Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russia.

Body weight is a complex trait in cattle associated with commonly used commercial breeding measurements related to growth. Although many quantitative trait loci (QTL) for body weight have been identified in cattle so far, searching for genetic determinants in different breeds or environments is promising. Therefore, we carried out a genome-wide association study (GWAS) in two cattle populations from the Russian Federation (Siberian region) using the GGP HD150K array containing 139 376 single nucleotide polymorphism (SNP) markers. Read More

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http://dx.doi.org/10.1111/age.12786DOI Listing

Whole blood transcriptome analysis reveals footprints of cattle adaptation to sub-arctic conditions.

Anim Genet 2019 Apr 7. Epub 2019 Apr 7.

Production Systems, Natural Resources Institute Finland (Luke), Myllytie 1, Jokioinen, FI-31600, Finland.

Indigenous cattle breeds in northern Eurasia have adapted to harsh climate conditions. The local breeds are important genetic resources with cultural and historical heritages, and therefore, their preservation and genetic characterization are important. In this study, we profiled the whole-blood transcriptome of two native breeds (Northern Finncattle and Yakutian cattle) and one commercial breed (Holstein) using high-throughput RNA sequencing. Read More

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http://dx.doi.org/10.1111/age.12783DOI Listing
April 2019
2 Reads

Development of a simple SLA-1 copy-number-variation typing and the comparison of typing accuracy between real-time quantitative and droplet digital PCR.

Anim Genet 2019 Apr 7. Epub 2019 Apr 7.

Department of Stem Cell and Regenerative Biology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea.

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http://dx.doi.org/10.1111/age.12785DOI Listing

Systematic analyses for candidate genes of milk production traits in water buffalo (Bubalus Bubalis).

Anim Genet 2019 Apr 1. Epub 2019 Apr 1.

Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Wuhan, 430070, China.

Water buffalo (Bubalus bubalis) is of great economic importance as a provider of milk and meat in many countries. However, the milk yield of buffalo is much lower than that of Holstein cows. Selection of candidate genes related to milk production traits can be applied to improve buffalo milk performance. Read More

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http://dx.doi.org/10.1111/age.12739DOI Listing
April 2019
1 Read

Rainbow trout resistance to bacterial cold water disease: two new quantitative trait loci identified after a natural disease outbreak on a French farm.

Anim Genet 2019 Mar 18. Epub 2019 Mar 18.

GABI, INRA, AgroParisTech, Université Paris-Saclay, F-78350, Jouy-en-Josas, France.

In rainbow trout farming, Flavobacterium psychrophilum, the causative agent of bacterial cold water disease, is responsible for important economic losses. Resistance to F. psychrophilum is heritable, and several quantitative trait loci (QTL) with moderate effects have been detected, opening up promising perspectives for the genetic improvement of resistance. Read More

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http://dx.doi.org/10.1111/age.12777DOI Listing
March 2019
1 Read

Association of a novel SNP in the ASIP gene with skin color in black-bone chicken.

Authors:
S Yu G Wang J Liao

Anim Genet 2019 Mar 18. Epub 2019 Mar 18.

Engineering Research Center of Sichuan Province Higher School of Local Chicken Breeds Industrialization in Southern Sichuan, College of Life Science, Leshan Normal University, Leshan, 614000, China.

The agouti signaling protein gene (ASIP) is a widely studied pigmentation gene that plays an important role in melanin synthesis. To determine the variety of ASIP expression in the Muchuan Black-Bone chicken, we examined genetic variation in the ASIP promoter region. A single nucleotide polymorphism (c. Read More

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http://dx.doi.org/10.1111/age.12768DOI Listing
March 2019
1 Read

Population structure and genetic diversity of four Henan pig populations.

Anim Genet 2019 Mar 18. Epub 2019 Mar 18.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.

To investigate the population structure and genetic diversity of Henan indigenous pig breeds, samples from a total of 78 pigs of 11 breeds were collected, including four pig populations from Henan Province, three Western commercial breeds, three Chinese native pig breeds from other provinces and one Asian wild boar. The genotyping datasets were obtained by genotyping-by-sequencing technology. We found a high degree of polymorphism and rapid linkage disequilibrium decay in Henan pigs. Read More

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http://dx.doi.org/10.1111/age.12775DOI Listing

Detecting selection signatures in three Iranian sheep breeds.

Anim Genet 2019 Mar 18. Epub 2019 Mar 18.

Department of Animal Science, Faculty of Animal and Aquatic Science, Sari Agricultural Sciences and Natural Resources University, Sari, 4818168984, Iran.

The objective of genome mapping is to achieve valuable insight into the connection between gene variants (genotype) and observed traits (phenotype). Part of that objective is to understand the selective forces that have operated on a population. Finding links between genotype-phenotype changes makes it possible to identify selective sweeps by patterns of genetic variation and linkage disequilibrium. Read More

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http://dx.doi.org/10.1111/age.12772DOI Listing

Genetic diversity and population structure in multiple Chinese goat populations using a SNP panel.

Anim Genet 2019 Mar 18. Epub 2019 Mar 18.

Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing, 100193, China.

Information about genetic diversity and population structure among goat breeds is essential for genetic improvement, understanding of environmental adaptation as well as utilization and conservation of goat breeds. Here, we measured genetic diversity and population structure in multiple Chinese goat populations, namely, Nanjiang, Qinggeda, Arbas Cashmere, Jining Grey, Luoping Yellow and Guangfeng goats. A total of 193 individuals were genotyped for about 47 401 autosomal single nucleotide polymorphisms (SNPs). Read More

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http://dx.doi.org/10.1111/age.12776DOI Listing

The European sea bass: a key marine fish model in the wild and in aquaculture.

Anim Genet 2019 Mar 18. Epub 2019 Mar 18.

MARBEC, Ifremer-CNRS-IRD-UM, Université de Montpellier, 34250, Palavas-les-Flots, France.

The European sea bass (Dicentrarchus labrax L.) is a marine fish of key economic and cultural importance in Europe. It is now more an aquaculture than a fisheries species (>96% of the production in 2016), although modern rearing techniques date back only from the late 1980s. Read More

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http://dx.doi.org/10.1111/age.12779DOI Listing

CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats.

Anim Genet 2019 Mar 10. Epub 2019 Mar 10.

Section of Medical Genetics (PennGen), Section of Medical Genetics (PennGen), School of Veterinary Medicine University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104-6010, USA.

In domestic cats, the AB blood group system consists of the three types A, B and C (also called AB). Mismatches can cause acute hemolytic transfusion reactions and hemolysis of the newborn (neonatal isoerythrolysis, NI). As blood types B and C are inherited recessively to A, breeders need to know the genotype to predict blood types in offspring and avoid NI. Read More

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http://dx.doi.org/10.1111/age.12778DOI Listing
March 2019
1 Read

Genetic diversity and maternal origin of Northeast African and South American donkey populations.

Anim Genet 2019 Mar 10. Epub 2019 Mar 10.

Key laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.

To investigate the mtDNA variation and origin of maternal lineages in South American donkeys and to reassess the domestication of donkeys in northeast Africa, we analyzed sequences (489 bp of the D-loop) from 323 domestic donkeys sampled from Peru, Brazil, Ethiopia and Egypt. Altogether, the 323 sequences displayed 53 different haplotypes (45 in Ethiopia, 14 in Egypt, eight in Peru and six in Brazil). Among the four populations, Egyptian donkeys possessed the highest haplotype diversity (0. Read More

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http://dx.doi.org/10.1111/age.12774DOI Listing
March 2019
1 Read

Genetic association of DDIT3, RPL23A, SESN2 and NR4A1 genes with milk yield and composition in dairy cattle.

Anim Genet 2019 Apr 28;50(2):123-135. Epub 2019 Feb 28.

Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, Beijing, 100193, China.

Previously, we identified by RNA sequencing that DDIT3, RPL23A, SESN2 and NR4A1 genes were significantly differentially expressed between the mammary glands of lactating Holstein cows with extremely high and low milk protein and fat percentages; thus, these four genes are considered as promising candidates potentially affecting milk yield and composition traits in dairy cattle. In the present study, we further verified whether these genes have genetic effects on milk traits in a Chinese Holstein population. By re-sequencing part of the non-coding and the entire coding regions of the DDIT3, RPL23A, SESN2 and NR4A1 genes, a total of 35 SNPs and three insertions/deletions were identified, of which three were found in DDIT3, 12 in RPL23A, 16 in SESN2 and seven in NR4A1. Read More

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http://dx.doi.org/10.1111/age.12750DOI Listing

Molecular cloning of WIF1 and HMGA2 reveals ear-preferential expression while uncovering a missense mutation associated with porcine ear size in WIF1.

Anim Genet 2019 Apr 28;50(2):157-161. Epub 2019 Feb 28.

State Key Laboratory of Animal Nutrition; Key Laboratory of Animal (Poultry) Genetics Breeding and Reproduction, Ministry of Agriculture; Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.

Considerable diversity exists in porcine ear size, which is an important morphological feature of pig breeds. Previously, we localized four crucial candidate genes-high mobility group AT-hook 2 (HMGA2), LEM domain-containing 3 (LEMD3), methionine sulfoxide reductase B3 (MSRB3) and Wnt inhibitory factor 1 (WIF1)-on Sus Scrofa chromosome 5 affecting porcine ear size, then cloned LEMD3 and MSBR3. In this study, we performed rapid amplification of cDNA ends to obtain full-length cDNA sequences of 2338-bp WIF1 and 2998-bp HMGA2. Read More

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http://dx.doi.org/10.1111/age.12759DOI Listing

Genome-wide association study identifies markers associated with meat ultimate pH in Duroc pigs.

Anim Genet 2019 Apr 28;50(2):154-156. Epub 2019 Feb 28.

Department of Agricultural and Food Sciences (DISTAL), Bologna University, Viale G. Fanin 46, 40127, Bologna, Italy.

In this study we aimed to identify genomic regions associated with muscle pH, meat colour and water-holding capacity in a population of 280 Italian Duroc pigs genotyped by the Illumina PorcineSNP60 v2 Genotyping BeadChip. After quality control, the remaining 32 597 SNPs and 278 subjects were used to perform a genome-wide association study with the genabel package, using a kinship matrix in a model with the effects of sex, age and slaughter day. Bonferroni correction was applied, and the significant markers and regions were then further investigated to identify the nearest genes and the linkage disequilibrium (LD) between markers. Read More

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http://dx.doi.org/10.1111/age.12757DOI Listing

Copy number variation and variant discovery in Bullmastiff dogs.

Anim Genet 2019 Apr 21;50(2):177-181. Epub 2019 Feb 21.

School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, NSW, 2006, Australia.

Identification of genomic variants within dogs is important for understanding genetic factors contributing to breed diversity and phenotypic traits. This study aimed to identify sources of variation in the Bullmastiff using high-density signal intensity and whole-genome sequence data. Close to 3000 copy number variants (CNVs) were identified in Bullmastiff dogs using Canine HD BeadChip data. Read More

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http://dx.doi.org/10.1111/age.12754DOI Listing

A 4-bp deletion in the ASIP gene is associated with the recessive black coat colour in domestic guinea pigs (Cavia porcellus).

Anim Genet 2019 Apr 12;50(2):190-191. Epub 2019 Feb 12.

College of Animal Science, Jilin University, Changchun, 130062, China.

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http://dx.doi.org/10.1111/age.12766DOI Listing
April 2019
3 Reads

Genome-wide association study identifies variants in the CAPN9 gene associated with umbilical hernia in pigs.

Anim Genet 2019 Apr 12;50(2):162-165. Epub 2019 Feb 12.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China.

Pig umbilical hernia (UH) affects pig welfare and brings considerable economic loss to the pig industry. To date, the molecular mechanisms underlying pig UH are still poorly understood. To identify potential loci for susceptibility to this disease, we performed a genome-wide association study in an Erhualian × Shaziling F intercross population. Read More

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http://dx.doi.org/10.1111/age.12760DOI Listing

Signatures of de-domestication in autochthonous pig breeds and of domestication in wild boar populations from MC1R and NR6A1 allele distribution.

Anim Genet 2019 Apr 11;50(2):166-171. Epub 2019 Feb 11.

Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy.

Autochthonous pig breeds are usually reared in extensive or semi-extensive production systems that might facilitate contact with wild boars and, thus, reciprocal genetic exchanges. In this study, we analysed variants in the melanocortin 1 receptor (MC1R) gene (which cause different coat colour phenotypes) and in the nuclear receptor subfamily 6 group A member 1 (NR6A1) gene (associated with increased vertebral number) in 712 pigs of 12 local pig breeds raised in Italy (Apulo-Calabrese, Casertana, Cinta Senese, Mora Romagnola, Nero Siciliano and Sarda) and south-eastern European countries (Krškopolje from Slovenia, Black Slavonian and Turopolje from Croatia, Mangalitsa and Moravka from Serbia and East Balkan Swine from Bulgaria) and compared the data with the genetic variability at these loci investigated in 229 wild boars from populations spread in the same macro-geographic areas. None of the autochthonous pig breeds or wild boar populations were fixed for one allele at both loci. Read More

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http://dx.doi.org/10.1111/age.12771DOI Listing
April 2019
2 Reads

The MUC1 gene polymorphism is not associated with milk productive traits and somatic cell count in Jersey cattle.

Anim Genet 2019 Apr 11;50(2):188-189. Epub 2019 Feb 11.

Departamento de Ecologia, Zoologia e Genética, Universidade Federal de Pelotas, Campus Universitário, Capão do Leão, Pelotas, Rio Grande do Sul, 96160-000, Brazil.

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http://dx.doi.org/10.1111/age.12773DOI Listing
April 2019
1 Read

Characterization and expression analysis of KIT and MITF-M genes in llamas and their relation to white coat color.

Anim Genet 2019 Apr 7;50(2):143-149. Epub 2019 Feb 7.

Laboratorio de Genética Molecular, Instituto Multidisciplinario de Biología Celular (IMBICE), CONICET-UNLP-CIC, Calle 526 e/10 y 11, La Plata, 1900, Buenos Aires, Argentina.

The llama (Lama glama) is a fiber-producing species that presents a wide range of coat colors, among which white is one of the most important for the textile industry. However, there is little information about the molecular mechanisms that control the white phenotype in this species. In domestic mammals, a white coat is usually produced by mutations in the KIT proto-oncogene receptor tyrosine kinase (KIT) and microphthalmia-associated transcription factor (MITF) genes. Read More

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http://dx.doi.org/10.1111/age.12769DOI Listing
April 2019
1 Read

Effective genetic markers for identifying the Escherichia coli F4ac receptor status of pigs.

Anim Genet 2019 Apr 6;50(2):136-142. Epub 2019 Feb 6.

Institute of Agricultural Sciences, ETH Zurich, Tannenstrasse 1, 8092, Zurich, Switzerland.

The F4ac receptor locus (F4acR), which encodes susceptibility or resistance to Escherichia coli diarrhoea, is inherited as an autosomal recessive monogenetic trait. F4acR is localized on pig chromosome 13 (SSC13q41-q44) near the MUC13 gene. Two flanking markers (CHCF1 and ALGA0106330) with a high linkage disequilibrium (LD) with F4acR were found to be effective for the genetic identification of F4ac-resistant pigs in the Swiss Large White breed (one recombinant out of 2034 genotyped pigs). Read More

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http://dx.doi.org/10.1111/age.12770DOI Listing

Genetic variation in CSN3 exon 4 region of Indian goats and a new nomenclature of CSN3 variants.

Anim Genet 2019 Apr 6;50(2):191-192. Epub 2019 Feb 6.

Animal Genomics Lab, Animal Biotechnology Center, ICAR-National Dairy Research Institute (NDRI), Karnal, 132001, India.

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http://dx.doi.org/10.1111/age.12767DOI Listing
April 2019
1 Read

Mocha tyrosinase variant: a new flavour of cat coat coloration.

Anim Genet 2019 Apr 4;50(2):182-186. Epub 2019 Feb 4.

Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri - Columbia, Columbia, MO, 65201, USA.

A novel coloration named 'mocha' has been identified in the Burmese cat breed from Thailand. Tyrosinase (TYR) mutations are known to be associated with coat coloration in cats, such as the sable Burmese, the points of the Siamese and albino cats. Additionally, sable Burmese that produced mocha-colored cats had unexpected genotypes for TYR. Read More

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http://dx.doi.org/10.1111/age.12765DOI Listing

Genome-wide analysis identifies potentially causative genes explaining the phenotypic variability in Pinzirita sheep.

Anim Genet 2019 Apr 15;50(2):189-190. Epub 2019 Jan 15.

Dipartimento di Agricoltura, Alimentazione, Ambiente, University of Catania, 95125, Catania, Italy.

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http://dx.doi.org/10.1111/age.12763DOI Listing

Hornless Nellore cattle (Bos indicus) carrying a novel 110 kbp duplication variant of the polled locus.

Anim Genet 2019 Apr 15;50(2):187-188. Epub 2019 Jan 15.

Department of Support, Production and Animal Health, School of Veterinary Medicine, São Paulo State University (Unesp), 16050-680 R. Clóvis Pestana 793 - Dona Amelia, Araçatuba/SP, Brazil.

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http://dx.doi.org/10.1111/age.12764DOI Listing

Whole-genome sequencing reveals a large deletion in the MITF gene in horses with white spotted coat colour and increased risk of deafness.

Anim Genet 2019 Apr 15;50(2):172-174. Epub 2019 Jan 15.

Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001, Bern, Switzerland.

White spotting phenotypes in horses are highly valued in some breeds. They are quite variable and may range from the common white markings up to completely white horses. EDNRB, KIT, MITF, PAX3 and TRPM1 represent known candidate genes for white spotting phenotypes in horses. Read More

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http://dx.doi.org/10.1111/age.12762DOI Listing
April 2019
1 Read

Genome-wide association studies pathway-based meta-analysis for residual feed intake in beef cattle.

Anim Genet 2019 Apr 15;50(2):150-153. Epub 2019 Jan 15.

Department of Animal Science, Universidade Federal de Viçosa, Viçosa, 36570-000, Minas Gerais, Brazil.

Genome-wide association studies (GWASes) have been performed to search for genomic regions associated with residual feed intake (RFI); however inconsistent results have been obtained. A meta-analysis may improve these results by decreasing the false-positive rate. Additionally, pathway analysis is a powerful tool that complements GWASes, as it enables identification of gene sets involved in the same pathway that explain the studied phenotype. Read More

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http://dx.doi.org/10.1111/age.12761DOI Listing

Comparing two commercial domestic dog (Canis familiaris) STR genotyping kits for forensic identity calculations in a mixed-breed dog population sample.

Anim Genet 2019 Feb 28;50(1):105-111. Epub 2018 Dec 28.

School of Mathematics and Natural Sciences, Arizona State University (ASU) at the West Campus, Glendale, AZ, 85306, USA.

Almost half of all US households own a dog (Canis familiaris). Though these household pets can attack humans and other animals, they are also frequently victims of cruelty, neglect and theft. In human-oriented investigations, the tendency of domestic dogs to leave behind physical traces (such as hair) can serve as valuable links between crime scenes and suspects/victims. Read More

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http://dx.doi.org/10.1111/age.12758DOI Listing
February 2019

Genome-wide differential DNA methylation in tropically adapted Creole cattle and their Iberian ancestors.

Anim Genet 2019 Feb 22;50(1):15-26. Epub 2018 Nov 22.

School of Biosciences, Cardiff University, Cathays Park, Cardiff, CF10 3AX, UK.

Enhancing climate resilience and sustainable production for animals in harsh environments are important goals for the livestock industry given the predicted impacts of climate change. Rapid adaptation to extreme climatic conditions has already been imposed on livestock species, including those exported after Columbus's arrival in the Americas. We compared the methylomes of two Creole cattle breeds living in tropical environments with their putative Spanish ancestors to understand the epigenetic mechanisms underlying rapid adaptation of a domestic species to a new and more physiologically challenging environment. Read More

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http://dx.doi.org/10.1111/age.12731DOI Listing
February 2019

Genetic diversity analysis of French goat populations reveals selective sweeps involved in their differentiation.

Anim Genet 2019 Feb 13;50(1):54-63. Epub 2018 Dec 13.

GenPhySE, INRA, Université de Toulouse, INPT, ENVT, 31326, Castanet Tolosan, France.

After domestication 11 000 years ago in Asia Minor, the goat followed human migration to Europe and Asia. It was then introduced in Africa and is now raised all over the world. In this study, we exploited a dataset composed of 54 000 SNPs (Illumina goat DNA chip) to analyze the genetic diversity of 223 individuals belonging to eight French breeds (Alpine, Angora, Corse, Fossés, Poitevine, Provençale, Pyrénées and Saanen). Read More

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http://dx.doi.org/10.1111/age.12752DOI Listing
February 2019

Comprehensive characterization of horse genome variation by whole-genome sequencing of 88 horses.

Anim Genet 2019 Feb 7;50(1):74-77. Epub 2018 Dec 7.

Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001, Bern, Switzerland.

Whole-genome sequencing studies are vital to gain a thorough understanding of genomic variation. Here, we summarize the results of a whole-genome sequencing study comprising 88 horses and ponies from diverse breeds at 19.1× average coverage. Read More

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http://dx.doi.org/10.1111/age.12753DOI Listing
February 2019

NHLRC1 dodecamer repeat expansion demonstrated by whole genome sequencing in a Chihuahua with Lafora disease.

Anim Genet 2019 Feb 7;50(1):118-119. Epub 2018 Dec 7.

Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001, Bern, Switzerland.

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http://dx.doi.org/10.1111/age.12756DOI Listing
February 2019

Four structural variants associated with human-directed sociability in dogs are not found in tame red foxes (Vulpes vulpes).

Anim Genet 2019 Feb 10;50(1):116-118. Epub 2018 Dec 10.

Department of Animal Science, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/age.12755
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http://dx.doi.org/10.1111/age.12755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349532PMC
February 2019
5 Reads

A non-coding regulatory variant in the 5'-region of the MITF gene is associated with white-spotted coat in Brown Swiss cattle.

Anim Genet 2019 Feb 2;50(1):27-32. Epub 2018 Dec 2.

Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001, Bern, Switzerland.

Recently, the Swiss breeding association reported an increasing number of white-spotted cattle in the Brown Swiss breed, which is normally solid brown coloured. A total of 60 Brown Swiss cattle with variably sized white abdominal spots, facial markings and depigmented claws were collected for this study. A genome-wide association study using 40k SNP genotypes of 20 cases and 1619 controls enabled us to identify an associated genome region on chromosome 22 containing the MITF gene, encoding the melanogenesis associated transcription factor. Read More

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http://dx.doi.org/10.1111/age.12751DOI Listing
February 2019

Comparative transcriptome analysis of Ethiopian indigenous chickens from low and high altitudes under heat stress condition reveals differential immune response.

Anim Genet 2019 Feb 25;50(1):42-53. Epub 2018 Nov 25.

Animal Genomics and Bioinformatics Division, National Institute of Animal Science, RDA, Wanju, 55365, Korea.

Ethiopia is an ecologically diverse country; the low altitude regions are hot and humid whereas the high altitude regions are cooler. In this study we analyzed the transcriptome response of high altitude (Addis Ababa) and low altitude (Awash) chickens to heat stress conditions that are prevalent in the low altitude regions. The chickens were free ranged for 20 h in an enclosure in Awash, and then the heart, breast muscle and spleen tissues were collected at 6:00 am, 12:00 noon and 6:00 pm to follow a daily circadian cycle. Read More

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http://dx.doi.org/10.1111/age.12740DOI Listing
February 2019
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A novel KRT71 variant in curly-coated dogs.

Anim Genet 2019 Feb 19;50(1):101-104. Epub 2018 Nov 19.

Department of Veterinary Biosciences, University of Helsinki, P.O. Box 66, 00014, Helsinki, Finland.

Curly fur is a common phenotype in many dog breeds, known to result from a missense variant (c.451C>T) in exon 2 of the keratin 71 (KRT71) gene. During screening for this variant across various breeds, we found that Curly Coated Retrievers (CCRs) fixed with the trait did not carry the known variant. Read More

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http://dx.doi.org/10.1111/age.12746DOI Listing
February 2019

A second KRT71 allele in curly coated dogs.

Anim Genet 2019 Feb 15;50(1):97-100. Epub 2018 Nov 15.

Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, 3001, Switzerland.

Major characteristics of coat variation in dogs can be explained by variants in only a few genes. Until now, only one missense variant in the KRT71 gene, p.Arg151Trp, has been reported to cause curly hair in dogs. Read More

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http://doi.wiley.com/10.1111/age.12743
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http://dx.doi.org/10.1111/age.12743DOI Listing
February 2019
24 Reads

Effects of genomic selection for intramuscular fat content in breast muscle in Chinese local chickens.

Anim Genet 2019 Feb 15;50(1):87-91. Epub 2018 Nov 15.

Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.

Improvements in living standards have resulted in consumers having higher expectations for chicken meat quality. This is particularly true in Asia, where there is high consumer preference for local breeds. Nothing is presently known about the effectiveness of using genomic selection (GS) strategies in chickens to genetically improve meat quality traits that cannot be measured in living potential parents. Read More

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http://doi.wiley.com/10.1111/age.12744
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http://dx.doi.org/10.1111/age.12744DOI Listing
February 2019
14 Reads

Atlantic salmon (Salmo salar L.) genetics in the 21st century: taking leaps forward in aquaculture and biological understanding.

Anim Genet 2019 Feb 14;50(1):3-14. Epub 2018 Nov 14.

School of Biological Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, UK.

Atlantic salmon (Salmo salar L.) is among the most iconic and economically important fish species and was the first member of Salmonidae to have a high-quality reference genome assembly published. Advances in genomics have become increasingly central to the genetic improvement of farmed Atlantic salmon as well as conservation of wild salmon stocks. Read More

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http://dx.doi.org/10.1111/age.12748DOI Listing
February 2019

SNP panel development for genetic management of wild and domesticated white bass (Morone chrysops).

Anim Genet 2019 Feb 14;50(1):92-96. Epub 2018 Nov 14.

School of Fisheries, Aquaculture, and Aquatic Sciences, Auburn University, Auburn, AL, 36849, USA.

White bass (Morone chrysops), striped bass and their interspecific hybrid are important game fishes, whereas the hybrid striped bass is an important aquaculture species in the US. Numerous state, federal and private hatcheries, therefore, rear these species for stocking purposes as well as for food fish. Although striped bass populations (both wild and domesticated) have been extensively evaluated, relatively little effort has been directed toward the study and improvement of white bass. Read More

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http://dx.doi.org/10.1111/age.12747DOI Listing
February 2019

Comprehensive analysis of the mitochondrial DNA diversity in Chinese cattle.

Anim Genet 2019 Feb 13;50(1):70-73. Epub 2018 Nov 13.

Key laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.

Complete mitochondrial DNA D-loop sequences of 1105 individuals were used to assess the diversity of maternal lineages of cattle populations in China. In total, 250 taurine and 88 zebu haplotypes were identified. Five main haplogroups-T1a, T2, T3, T4 and T5-were identified in Bos taurus, whereas Bos indicus harbored two haplogroups-I1 and I2. Read More

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http://dx.doi.org/10.1111/age.12749DOI Listing
February 2019