104 results match your criteria Animal Cells And Systems[Journal]


Functional morphology and structural characteristics of the hind wings of the bamboo weevil (Coleoptera, Curculionidae).

Anim Cells Syst (Seoul) 2019 Apr 24;23(2):143-153. Epub 2019 Mar 24.

College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, People's Republic of China.

Research data of the microstructure and surface morphology of insect wings have been used to help design micro air vehicles (MAV) and coating materials. The present study aimed to examine the microstructure and morphology of the hind wings of using inverted fluorescence microscopy (IFM), scanning electron microscopy (SEM), and a mechanical testing system. IFM was used to investigate the distribution of resilin in the hind wing, and SEM was performed to assess the functional characteristics and cross-sectional microstructure of the wings. Read More

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http://dx.doi.org/10.1080/19768354.2019.1592020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440521PMC

Differential activity of 16K rat prolactin in different organic systems.

Anim Cells Syst (Seoul) 2019 Apr 20;23(2):135-142. Epub 2019 Feb 20.

Department of Life Science, The Catholic University of Korea, Bucheon, Korea.

The 16K isoform of rat prolactin (16K rPRL) performs multiple functions in various systems including angiogenesis, tumorigenesis, and reproduction. Recently, 16K rPRL has attained prominence as a possible therapeutic target in pathophysiological conditions. However, the integral function and mechanism of 16K rPRL in various systems has not been elucidated. Read More

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http://dx.doi.org/10.1080/19768354.2018.1554543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440500PMC
April 2019
1 Read

Upregulated lncRNA Gm2044 inhibits male germ cell development by acting as miR-202 host gene.

Anim Cells Syst (Seoul) 2019 Apr 14;23(2):128-134. Epub 2019 Mar 14.

Department of Biological Sciences, Bengbu Medical College, Bengbu, People's Republic of China.

Long non-coding RNAs (lncRNAs) have been found to participate in the regulation of human spermatogenic cell development. However, little is known about the abnormal expression of lncRNAs associated with spermatogenic failure and their molecular mechanisms. Using lncRNA microarray of testicular tissue for male infertility and bioinformatics methods, we identified the relatively conserved lncRNA Gm2044 which may play important roles in non-obstructive azoospermia. Read More

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http://dx.doi.org/10.1080/19768354.2019.1591506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440523PMC

Platycodin D, a bioactive component of , induces cancer cell death associated with extreme vacuolation.

Anim Cells Syst (Seoul) 2019 Apr 5;23(2):118-127. Epub 2019 Mar 5.

Department of Molecular Medicine, Inha University College of Medicine, Incheon, Republic of Korea.

Platycodin D (PD) is a major active component of the roots of and possesses multiple biological and pharmacological properties, including anti-cancer activity. The aim of this study was to characterize PD-induced cytoplasmic vacuolation in human cancer cells and investigate the underlying mechanisms. PD-induced cancer cell death was associated with cytoplasmic pinocytic and autophagic vacuolation. Read More

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http://dx.doi.org/10.1080/19768354.2019.1588163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440520PMC
April 2019
1 Read

VNN3 is a potential novel biomarker for predicting prognosis in clear cell renal cell carcinoma.

Anim Cells Syst (Seoul) 2019 Apr 1;23(2):112-117. Epub 2019 Mar 1.

Department of Anatomy, Pusan National University School of Medicine, Yangsan, Republic of Korea.

Although pathological observations provide approximate prognoses, it is difficult to achieve prognosis in patients with existing prognostic factors. Therefore, it is very important to find appropriate biomarkers to achieve accurate cancer prognosis. Renal cell carcinoma (RCC) has several subtypes, the discrimination of which is crucial for proper treatment. Read More

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http://dx.doi.org/10.1080/19768354.2019.1583126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440501PMC
April 2019
1 Read

G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses.

Anim Cells Syst (Seoul) 2019 Apr 1;23(2):106-111. Epub 2019 Mar 1.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Gunpo-si, Republic of Korea.

Leucine rich-repeat kinase 2 (LRRK2) is involved in the pathogenesis of Parkinson's disease (PD). LRRK2 has kinase and GTPase activities, and mediates several cell functions, including vesicle trafficking, apoptosis, autophagy, mitochondrial dynamics, and neuroinflammation. G2019S (GS) is the most prevalent mutation of LRRK2. Read More

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https://www.tandfonline.com/doi/full/10.1080/19768354.2019.1
Publisher Site
http://dx.doi.org/10.1080/19768354.2019.1585948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440522PMC
April 2019
4 Reads

Immune response of heterologous recombinant antigenic protein of viral hemorrhagic septicemia virus (VHSV) in mice.

Anim Cells Syst (Seoul) 2019 Apr 8;23(2):97-105. Epub 2019 Feb 8.

Department of Medicine, College of Medicine, Chung-Ang University, Seoul, South Korea.

Viral hemorrhagic septicemia (VHS) is an important infectious disease in fish worldwide caused by viral hemorrhagic septicemia virus (VHSV). VHSV is the causative agent of serious systemic diseases in fish, affecting a number of teleost fish species. In this study, VHSV glycoprotein (G), including its epitope, as a subunit vaccine candidate, was expressed in tobacco plant (). Read More

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http://dx.doi.org/10.1080/19768354.2019.1575904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440531PMC

A case study of male tawny owl () vocalizations in South Korea: call feature, individuality, and the potential use for census.

Anim Cells Syst (Seoul) 2019 Apr 19;23(2):90-96. Epub 2019 Mar 19.

Research Center of Ecomimetics and Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea.

Vocal individuality has been used as a monitoring tool, and two criteria are a prerequisite: high variation among individuals and low variation within individuals, and vocal consistency within and across seasons. We examined individual variation in the territorial hoot calls of the tawny owl () to discriminate between males and to assess a possible conservation technique that would allow for monitoring individuals within a study area. The territorial calls were recorded from five males in the Naejang Mountain National Park in South Korea during the breeding season in 2015 and 2016 and analyzed both quantitatively and qualitatively to determine the amount of variation within and between individuals. Read More

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http://dx.doi.org/10.1080/19768354.2019.1592022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440519PMC

MiR-15b can target insulin receptor to regulate hepatic insulin signaling in mice.

Anim Cells Syst (Seoul) 2019 Apr 27;23(2):82-89. Epub 2019 Feb 27.

Department of Preventive Medicine, Jiangsu health vacation College, Nanjing, Jiangsu Province, People's Republic of China.

Now diabetes is growing to be a health problems globally. However, its specific pathogenesis still needs further exploration. Here we showed that miR-15b was upregulated in the palmitate-induced HepG2 cells and livers of hyperglycemic mice. Read More

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http://dx.doi.org/10.1080/19768354.2019.1583125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440518PMC

Hydrangenol suppresses VEGF-stimulated angiogenesis by targeting p27KIP1-dependent G1-cell cycle arrest, VEGFR-2-mediated signaling, and MMP-2 expression.

Anim Cells Syst (Seoul) 2019 Apr 14;23(2):72-81. Epub 2019 Feb 14.

Department of Food and Nutrition, Chung-Ang University, Anseong, Republic of Korea.

We previously reported that hydrangenol has potent antitumor activity against human bladder cancer EJ cells. Here, we investigated the antiangiogenic activity of hydrangenol using and models. Treatment with hydrangenol significantly inhibited the proliferation of vascular endothelial growth factor (VEGF)-induced HUVECs in a concentration-dependent manner (EC= 10 μM). Read More

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http://dx.doi.org/10.1080/19768354.2019.1578262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440517PMC
April 2019
1 Read

Spring and summer microhabitat use by Schlegel's Japanese gecko, (Reptilia: Squamata: Gekkonidae), in urban areas.

Anim Cells Syst (Seoul) 2019 Feb 4;23(1):64-70. Epub 2018 Dec 4.

Division of Science Education, Kangwon National University, Chuncheon, South Korea.

Differential microhabitat use may be beneficial to achieving fitness in seasonally variable environmental conditions. To explore whether the microhabitat use of the nocturnal Schlegel's Japanese gecko, , varies seasonally and depends on juvenile, male, and female reproductive groups, we investigated five categorical and five quantitative measure variables of microhabitat use in a wild population both in spring and summer. Most geckos were found on white, vertical planes of concrete and plastered brick walls. Read More

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http://dx.doi.org/10.1080/19768354.2018.1554542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394305PMC
February 2019
1 Read

A new southern distribution limit for Ognev, 1937 (Eulipotyphla, Soricidae).

Anim Cells Syst (Seoul) 2019 Feb 3;23(1):59-63. Epub 2019 Jan 3.

Department of Forest Sciences, CALS, Seoul National University, Seoul, Korea.

, a small insectivorous mammal, is a very rare, poorly known species distributed at high latitudes and altitudes of northeastern Asia. The occurrence of this species in the Republic of Korea was known from late 1990s. We found a new specimen from a location of a 50' lower latitude and 400 m lower altitude than the previously known locations of the first record in the Republic of Korea. Read More

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http://dx.doi.org/10.1080/19768354.2018.1561515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394333PMC
February 2019

Comparison of long noncoding RNA between muscles and adipose tissues in beef cattle.

Anim Cells Syst (Seoul) 2019 Feb 20;23(1):50-58. Epub 2018 Dec 20.

Department of Animal Biotechnology, College of Agricultural and Life Sciences, Chonbuk National University, Jeonju, Republic of Korea.

Long noncoding RNAs (lncRNAs) regulate the expression of mRNA and can affect various biological processes and phenotypes. Currently, studies of lncRNAs in cattle are under way, but their exact function for several tissues has not yet been established. cattle () have inhabited the Korean peninsula for about 6000 years and are one of the representative domesticated animals in Korea. Read More

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http://dx.doi.org/10.1080/19768354.2018.1512522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394308PMC
February 2019

Potential use of transgenic domestic pigs expressing recombinant human erythropoietin in diabetes translation research.

Anim Cells Syst (Seoul) 2019 Feb 18;23(1):42-49. Epub 2018 Dec 18.

Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, Republic of Korea.

Recently, diabetes mellitus (DM) has shown rapid global increases with about five million deaths annually. Animal models are imperative to understand disease mechanisms and develop diagnostic, preventive, and therapeutic interventions in translational research. Rodent and mini-pig models have been established and widely used for DM research. Read More

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http://dx.doi.org/10.1080/19768354.2018.1554544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394289PMC
February 2019
1 Read

Lithium chloride promotes proliferation of neural stem cells , possibly by triggering the Wnt signaling pathway.

Anim Cells Syst (Seoul) 2019 Feb 30;23(1):32-41. Epub 2018 Nov 30.

Department of Neurobiology, The Third Military Medical University, Chongqing, People's Republic of China.

The objective of this study was to clarify the relationship between the effect and associated mechanisms of lithium chloride on neural stem cells (NSCs) and the Wnt signaling pathway. The expression of key molecules proteins related to the Wnt signaling pathway in the proliferation and differentiation of control NSCs and lithium chloride-treated NSCs was detected by Western blot analysis. Flow cytometry analysis was applied to study the cell cycle dynamics of control NSCs and NSCs treated with lithium chloride. Read More

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http://dx.doi.org/10.1080/19768354.2018.1487334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394309PMC
February 2019
0.440 Impact Factor

Znf76 is associated with development of the eyes, midbrain, MHB, and hindbrain in zebrafish embryos.

Anim Cells Syst (Seoul) 2019 Feb 22;23(1):26-31. Epub 2019 Feb 22.

Department of Bioscience and Biotechnology, Graduate School, Chungnam National University, Daejeon, South Korea.

ZNF76 is a transcriptional repressor that targets the TATA-binding protein (TBP) and plays an essential role during brain development; however, its function during embryogenesis remains unclear. Here, we report the expression pattern and potential functions of in zebrafish embryos. Maternal transcripts of were detected at low levels in embryos at the 1-cell stage, with zygotic transcripts appearing at the sphere stage. Read More

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http://dx.doi.org/10.1080/19768354.2018.1557744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394295PMC
February 2019
1 Read

β-Adrenergic receptor (β-AR) agonist formoterol suppresses differentiation of L6 myogenic cells by blocking PI3K-AKT pathway.

Anim Cells Syst (Seoul) 2019 Feb 22;23(1):18-25. Epub 2019 Feb 22.

Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, Republic of Korea.

β-Adrenergic receptor (β-AR) is implicated in muscle metabolic activities such as glycogen metabolism, glucose uptake, lipolysis and muscle growth. However, the functional role of β-AR in the differentiation of skeletal muscle is largely unknown. Here, we examined the functional role of β-AR in L6 myoblast differentiation using the long-term-acting β-AR-specific agonist formoterol. Read More

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http://dx.doi.org/10.1080/19768354.2018.1561516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394304PMC
February 2019

Effects of hypoxic preconditioning on memory evaluated using the T-maze behavior test.

Anim Cells Syst (Seoul) 2019 Feb 12;23(1):10-17. Epub 2019 Feb 12.

Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Ansan, Korea.

Perioperative brain ischemia and stroke are leading causes of morbidity and mortality. Brief hypoxic preconditioning is known to have protective effects against hypoxic-ischemic insult in the brain. Current studies on the neuroprotective effects of ischemic preconditioning are based on histologic findings and biomarker changes. Read More

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http://dx.doi.org/10.1080/19768354.2018.1557743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394327PMC
February 2019

The ATP-dependent RNA helicase, DDX42 interacts with paxillin and regulates apoptosis and polarization of Ba/F3 cells.

Anim Cells Syst (Seoul) 2019 Feb 21;23(1):1-9. Epub 2019 Jan 21.

Department of Biochemistry, Medical School, Chonnam National University, Jeollanam-do, Republic of Korea.

Paxillin is a focal adhesion adaptor protein, heavily phosphorylated at multiple tyrosine residues, as well as at serine 273 (S273), and is known to be critical for cytoskeleton rearrangement and cell migration. We previously found that paxillin plays a regulatory role in IL-3-dependent survival of Ba/F3 cells, a mouse pro-B cell line. In this study, by using overexpressed His6 tagged-paxillin as a bait, we found that DDX42, a DEAD-box RNA helicase, interacted with paxillin, inhibited apoptosis, and promoted polarization of Ba/F3 cells. Read More

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http://dx.doi.org/10.1080/19768354.2019.1567580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394298PMC
February 2019

Gastrodin exerts robust neuroprotection in the postischemic brain via its protective effect against Zn-toxicity and its anti-oxidative effects in astrocytes.

Anim Cells Syst (Seoul) 2018 30;22(6):429-437. Epub 2018 Nov 30.

Department of Anatomy, Inha University School of Medicine, Incheon, Republic of Korea.

Gastrodin (GAS) is a predominant bioactive constituent of the Chinese herbal medicine Tianma ( Blume). Many authors have reported GAS has the beneficial effect on diverse diseases of the CNS, including epilepsy, Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Here, we report GAS exhibited a robust neuroprotective effect in an Sprague-Dawley rat model of stroke (transient middle cerebral artery occlusion, tMCAO), and show that the underlying molecular mechanism involves its protective effect against Zn-toxicity and its anti-oxidative effects in astrocytes. Read More

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https://www.tandfonline.com/doi/full/10.1080/19768354.2018.1
Publisher Site
http://dx.doi.org/10.1080/19768354.2018.1549099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282451PMC
November 2018
8 Reads

Fine structure of the aggregate silk nodules in the orb-web spider .

Authors:
Myung-Jin Moon

Anim Cells Syst (Seoul) 2018 14;22(6):421-428. Epub 2018 Nov 14.

Department of Biological Sciences, Dankook University, Cheonan, South Korea.

Among the triad spinning units for capture thread producing system in the orb-web spiders, aqueous gluey substances are produced from two pairs of aggregate silk glands (ASG). Although biochemical analysis of glue substance is produced by way of their passage through the ASG, its structural modifications in the nodular area have been nearly neglected till now. This paper focused on identifying the fine structural characteristics of the aggregate nodules in the golden orb-web spider using both of light and transmission electron microscopes. Read More

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http://dx.doi.org/10.1080/19768354.2018.1546227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282475PMC
November 2018
1 Read

A revision of the genus (Mollusca: Gastropoda) in Korea.

Anim Cells Syst (Seoul) 2018 14;22(6):415-420. Epub 2018 Nov 14.

Division of EcoScience, Ewha Womans University, Seoul, Korea.

Férussac, 1822 is an abundant genus of small gastropods found in the upper littoral zone of rocky seashores worldwide. Although ecologically important, shell-based species identification in this genus is challenging due to phenotypic variation in shell morphology and lack of diagnostic characters among morphologically similar species. In this study, we revised the taxonomy of Korean species using morphological characters (shell and radula) and mitochondrial DNA sequences for three Korean species: , and . Read More

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http://dx.doi.org/10.1080/19768354.2018.1545697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282416PMC
November 2018
2 Reads

Steroidogenic effects of extract on the levels of steroidogenic enzymes in mouse Leydig cells.

Anim Cells Syst (Seoul) 2018 8;22(6):407-414. Epub 2018 Nov 8.

Department of Urology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

In this study, we investigated the steroidogenic effect of extract on mouse TM3 Leydig cells, which produce male hormones by increasing the levels of steroidogenic enzymes. Steroidogenic enzymes are involved in the production of testosterone in the testis. To date, the steroidogenic effect of has not been reported. Read More

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http://dx.doi.org/10.1080/19768354.2018.1494628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282421PMC
November 2018
1 Read

Protective effects of ginsenoside Rg2 and astaxanthin mixture against UVB-induced DNA damage.

Anim Cells Syst (Seoul) 2018 9;22(6):400-406. Epub 2018 Oct 9.

Research Institute for Basic Science and Division of Biological Science, Wonkwang University, Iksan, Korea.

Ultraviolet B (UVB) radiation induces skin damage, skin matrix degradation, and wrinkle formation through photochemical reaction and oxidative stress. Therefore, protecting the skin from UVB can prevent skin aging. In this study, we investigated the effects of a mixture (RA) of Rg2, a ginsenoside, and astaxanthin, an antioxidant, on the responses of HaCaT cells exposed to UVB (700 J/m). Read More

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https://www.tandfonline.com/doi/full/10.1080/19768354.2018.1
Publisher Site
http://dx.doi.org/10.1080/19768354.2018.1523806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282468PMC
October 2018
22 Reads
0.440 Impact Factor

Involvement of inflammatory responses in the early development of calcific aortic valve disease: lessons from statin therapy.

Anim Cells Syst (Seoul) 2018 28;22(6):390-399. Epub 2018 Sep 28.

Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.

Calcific aortic valve disease (CAVD) is the most common degenerative heart valve disease. Among the many risk factors for this disease are age, hypercholesterolemia, hypertension, smoking, type-2 diabetes, rheumatic fever, and chronic kidney disease. Since many of these overlap with risk factors for atherosclerosis, the molecular and cellular mechanisms of CAVD development have been presumed to be similar to those for atherogenesis. Read More

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http://dx.doi.org/10.1080/19768354.2018.1528175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282465PMC
September 2018
8 Reads

Upregulation of autophagy by Ginsenoside Rg2 in MCF-7 cells.

Anim Cells Syst (Seoul) 2018 19;22(6):382-389. Epub 2018 Nov 19.

Division of Biological Sciences, Wonkwang University, Iksan, Republic of Korea.

Autophagy is a major intracellular degradation process that plays an important role in cell survival, stress responses, nutrient sensing and development. Our previous studies have shown that Rg2, a triterpenoid saponin contained in ginseng, protects cells against UVB-induced genotoxicity by increasing DNA repair, in possible association with modulation of protein levels involved in p53 pathway. In this study, we determined an upregulation of autophagy by Rg2. Read More

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https://www.tandfonline.com/doi/full/10.1080/19768354.2018.1
Publisher Site
http://dx.doi.org/10.1080/19768354.2018.1545696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282429PMC
November 2018
2 Reads
0.440 Impact Factor

Pancreatic-cancer-cell-derived trefoil factor 2 impairs maturation and migration of human monocyte-derived dendritic cells .

Anim Cells Syst (Seoul) 2018 1;22(6):368-381. Epub 2018 Oct 1.

Institute for Healthcare and Life Science and Institute for Translational and Clinical Research, Catholic Kwandong University International St. Mary's Hospital, Incheon, Republic of Korea.

Pancreatic cancer is a challenging disease with a high mortality rate. While the importance of crosstalk between cancer and immune cells has been well documented, the understanding of this complex molecular network is incomplete. Thus, identification of the secreted proteins contributing to the immunosuppressive microenvironment in pancreatic cancer is crucial for effective diagnosis and/or therapy. Read More

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http://dx.doi.org/10.1080/19768354.2018.1527721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282439PMC
October 2018

BRG1 Promotes chromatin remodeling around DNA damage sites.

Anim Cells Syst (Seoul) 2018 1;22(6):360-367. Epub 2018 Oct 1.

Department of Bioscience, Changchun Normal University, Changchun, People's Republic of China.

Chromatin remodeling complexes play important roles in various DNA metabolism processes, including DNA damage repair. BRG1 is the core subunit of the SWI/SNF complex, which plays critical roles in cell cycle regulation, cell development, cell differentiation, and tumorigenesis. In the present study, we report that BRG1 depletion increased the percentage of apoptotic cells in etoposide-treated cells. Read More

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http://dx.doi.org/10.1080/19768354.2018.1525429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282460PMC
October 2018
1 Read

Zebrafish model of -initiated pancreatic cancer.

Anim Cells Syst (Seoul) 2018 8;22(6):353-359. Epub 2018 Oct 8.

Department of Molecular and Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

Pancreatic cancer constitutes a genetic disease in which somatic mutations in the proto-oncogene are detected in a majority of tumors. mutations represent an early event during pancreatic tumorigenesis that crucial for cancer initiation and progression. Here, we established a zebrafish pancreatic cancer model that highly recapitulates human pancreatic intraepithelial neoplasia (PanIN) development. Read More

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http://dx.doi.org/10.1080/19768354.2018.1530301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282427PMC
October 2018
6 Reads

Multiple calmodulin genes of the Pacific abalone, (Mollusca: Vetigastropoda: Haliotidae).

Anim Cells Syst (Seoul) 2018 19;22(5):341-351. Epub 2018 Sep 19.

Department of Marine and Fisheries Resources, Mokpo National University, Korea.

In this study, we identified four canonical calmodulin genes in the Pacific abalone, . Their full-length cDNAs were variable in the 5' and 3' untranslated regions, but highly similar (91-97%) in the coding region. Each of the genes encoded 149 amino acids, with 93-97% similarity among themselves and 94-98% similarity with human CAM I. Read More

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http://dx.doi.org/10.1080/19768354.2018.1509126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171432PMC
September 2018
15 Reads

Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis.

Anim Cells Syst (Seoul) 2018 30;22(5):334-340. Epub 2018 Aug 30.

Department of Biological Sciences, College of Natural Sciences, Wonkwang University, Iksan, Chunbuk, Korea.

Here, we investigated the possible anti-cancer properties of bromelain in Kras mutant human colorectal carcinoma cell lines and a mouse model harboring a Kras mutation. Cell growth and proliferation were significantly reduced in the Kras mutant colorectal carcinoma cell lines following treatment with 50 μg/mL bromelain as assessed by crystal violet staining and a proliferation assay. To identify the molecules responsible for this action, the expression levels of genes involved in signaling pathways and miRNAs were analyzed by real-time PCR. Read More

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http://dx.doi.org/10.1080/19768354.2018.1512521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171431PMC
August 2018
17 Reads

Modulatory effect of linoleic and oleic acid on cell proliferation and lipid metabolism gene expressions in primary bovine satellite cells.

Anim Cells Syst (Seoul) 2018 9;22(5):324-333. Epub 2018 Sep 9.

Department of Animal Biotechnology, Chonbuk National University, Jeonju-si, Republic of Korea.

This study was performed to elucidate the effects of linoleic acid (LA), oleic acid (OA) and their combination (LA + OA) on cell proliferation, apoptosis, necrosis, and the lipid metabolism related gene expression in bovine satellite cells (BSCs), isolated from bovine muscles. Cell viability was significantly increased with the OA and LA treatment. Furthermore, LA + OA enhanced cell proliferation in a dose-dependent manner (10 to 100 µM), whereas it lowered at 250 µM. Read More

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http://dx.doi.org/10.1080/19768354.2018.1517824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171434PMC
September 2018
11 Reads
0.440 Impact Factor

The effects of mouse ovarian granulosa cell function and related gene expression by suppressing BMP/Smad signaling pathway.

Anim Cells Syst (Seoul) 2018 19;22(5):317-323. Epub 2018 Sep 19.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, People's Republic of China.

BMP I type receptor inhibitor can selectively inhibit BMP/Smad signaling pathways, mainly by inhibiting the BMP I type receptor activity to prevent phosphorylation of Smad1, Smad5 and Smad9. The aim of the present study was to explore the effects of mouse ovarian granulosa cell function and related gene expression by suppressing BMP/Smad signaling pathway with LDN-193189(A type of BMP I type receptor inhibitor). In this study, we cultivate the original generation of mouse ovarian granular cells then collect cells and cell culture medium after treatment. Read More

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http://dx.doi.org/10.1080/19768354.2018.1497706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171428PMC
September 2018
11 Reads
0.440 Impact Factor

Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats.

Anim Cells Syst (Seoul) 2018 5;22(5):305-316. Epub 2018 Sep 5.

Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

Neuroinflammation is considered a major factor in several neuropsychiatric disorders. Gypenosides (GPS) have pharmacological properties with multiple beneficial effects including antiinflammatory, antioxidative, and protective properties. The present study was performed to examine whether GPS shows anxiolytic-like effects in a model of chronic inflammation induced by injection of lipopolysaccharide (LPS) into the rat hippocampus. Read More

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http://dx.doi.org/10.1080/19768354.2018.1517825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171448PMC
September 2018
17 Reads

The microRNA-127-3p directly targeting in C2C12 myoblasts.

Anim Cells Syst (Seoul) 2018 25;22(5):299-304. Epub 2018 Aug 25.

Herbivorous Livestock Institute, Chongqing Academy of Animal Sciences, Chongqing, People's Republic of China.

MicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well elucidated. Read More

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http://dx.doi.org/10.1080/19768354.2018.1512520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171451PMC
August 2018
13 Reads
0.440 Impact Factor

Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1.

Authors:
Min Jung Kim

Anim Cells Syst (Seoul) 2018 30;22(5):289-298. Epub 2018 Aug 30.

Department of Biological Sciences, Sookmyung Women's University, Seoul, South Korea.

Betaine is a key metabolite of the methionine cycle and known for attenuating alcoholic steatosis in the liver. Recent studies have focused on the protection effect of betaine in mitochondrial regulation through the enhanced oxidative phosphorylation system. However, the mechanisms of its beneficial effects have not been clearly identified yet. Read More

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http://dx.doi.org/10.1080/19768354.2018.1512523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171430PMC
August 2018
6 Reads

Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment.

Anim Cells Syst (Seoul) 2018 5;22(5):281-288. Epub 2018 Sep 5.

Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, South Korea.

Chemotherapy-induced bone marrow damage is accompanied by acute nerve injury in the bone marrow (BM), resulting in sensory and autonomic neuropathy. Cisplatin, a popular chemotherapy drugs, induces the impairment of hematopoietic stem cells (HSCs) and bone marrow regeneration, leading to chronic bone marrow abnormalities. Previously, we reported the protective roles of neuropeptide Y (NPY) against cisplatin-induced bone marrow impairment. Read More

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http://dx.doi.org/10.1080/19768354.2018.1517826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171453PMC
September 2018
9 Reads

Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity.

Anim Cells Syst (Seoul) 2018 12;22(5):273-280. Epub 2018 Sep 12.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Gunpo-si, Republic of Korea.

Leucine-rich repeat kinase 2 (LRRK2) is involved in Parkinson's disease (PD) pathology. A previous study showed that rotenone treatment induced apoptosis, mitochondrial damage, and nucleolar disruption via up-regulated LRRK2 kinase activity, and these effects were rescued by an LRRK2 kinase inhibitor. Heat-shock protein 70 (Hsp70) is an anti-oxidative stress chaperone, and overexpression of Hsp70 enhanced tolerance to rotenone. Read More

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http://dx.doi.org/10.1080/19768354.2018.1518262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171436PMC
September 2018
15 Reads

Directional raids by army ants as an adaption to patchily distributed food: a simulation model.

Anim Cells Syst (Seoul) 2018 17;22(4):267-272. Epub 2018 Jul 17.

School of Biological Sciences, Seoul National University, Seoul, South Korea.

A typical colony of Neotropical army ants (subfamily Ecitoninae) regularly raids a large area around their bivouac by forming a narrow directional column that can reach up to one hundred meters in length. The raid is finished and then relaunched 12-17 times, each time toward different orientation. After completing all bouts the colony relocates to a new area. Read More

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http://dx.doi.org/10.1080/19768354.2018.1497708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138339PMC

Breeding biology of two wagtail subspecies on Ulleung Island, Korea: Amur Wagtails, and Black-backed Wagtails, .

Anim Cells Syst (Seoul) 2018 18;22(4):259-266. Epub 2018 Jul 18.

Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, Korea.

There is much controversy over the species and subspecies status of the white wagtail complex, which is further compounded by interbreeding between two subspecies, the Amur Wagtail () and the Black-backed Wagtail (). This study presents preliminary information on the breeding biology of both subspecies on Ulleung Island, Korea, over two breeding seasons (2012-2013). Mixed pairs of the two subspecies were common on this island, with almost 50% of all pairs being heterotypic or intermediate pairs; however, assortative mating was still present. Read More

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http://dx.doi.org/10.1080/19768354.2018.1496949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138363PMC
July 2018
1 Read

Genetic individualization of sable ( L. 1758) using microsatellites.

Anim Cells Syst (Seoul) 2018 9;22(4):253-258. Epub 2018 Jul 9.

College of Wildlife Resources, Northeast Forestry University, Harbin, People's Republic of China.

Genetic individualization based on non-invasive sampling is crucial for estimating the numbers of individuals in endangered mammalian populations. In sable ()-poaching cases, identifying the number of animals involved is critical for determining the penalty. In addition, investigating animal numbers for wild sable populations requires genetic individualization when collecting several samples in neighboring regions. Read More

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http://dx.doi.org/10.1080/19768354.2018.1494039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138352PMC
July 2018
1 Read
0.440 Impact Factor

High-fat-diet impaired mitochondrial function of cumulus cells but improved the efficiency of parthenogenetic embryonic quality in mice.

Anim Cells Syst (Seoul) 2018 22;22(4):243-252. Epub 2018 Aug 22.

College of Life Sciences, Northwest University, Xi'an, People's Republic of China.

Global human health has been compromised by high-fat diets. This study aimed to investigate the relationship between a high-fat diet and parthenogenetic embryo quality. Mice fed a high-fat or a normal diet was used as treated or control groups, respectively. Read More

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http://dx.doi.org/10.1080/19768354.2018.1497707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138337PMC
August 2018
21 Reads

Time-series transcriptomic analysis of the kelp grouper in response to low salinity stress.

Anim Cells Syst (Seoul) 2018 22;22(4):234-242. Epub 2018 Aug 22.

Aquatic Technology Promoting Station of Meijiang District, Meizhou, People's Republic of China.

The Kelp grouper is one of the most widely consumed and economically important marine fish in China. The species can tolerate a wide range of salinity, but genomic resources are not available, and the molecular mechanisms underlying adaptation to salinity at the transcriptomic level remain largely unclear. In this study, the transcriptomic responses of the liver of under low salinity were investigated using the Illumina digital gene expression system. Read More

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http://dx.doi.org/10.1080/19768354.2018.1487335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138362PMC
August 2018
12 Reads

Characterization of changes of pain behavior and signal transduction system in food-deprived mice.

Anim Cells Syst (Seoul) 2018 28;22(4):227-233. Epub 2018 Jun 28.

Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University, Chuncheon, Korea.

Fasting in general causes several metabolic changes. In the present study, we examined the possible changes of several types of nociception during the food deprivation were investigated in mice. After the mice were forced into the fasting for 12, 24, or 48 h, the changes of nociception were measured by the tail-flick, writhing, formalin or von-frey tests. Read More

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http://dx.doi.org/10.1080/19768354.2018.1490348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138332PMC
June 2018
13 Reads

Repeated immune activation with low-dose lipopolysaccharide attenuates the severity of Huntington's disease in R6/2 transgenic mice.

Anim Cells Syst (Seoul) 2018 20;22(4):219-226. Epub 2018 Jun 20.

Department of Integrative Bioscience and Biotechnology, Institute of Anticancer Medicine Development, Sejong University, Seoul, Korea.

Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the huntingtin gene. Previously, therapeutic approaches using anti-inflammatory agents were reportedly not effective for preventing HD progression. Since whether immune responses contribute to the onset of HD is not entirely understood, we herein investigated the role of immune activation in HD using the R6/2 transgenic (Tg) HD model mouse. Read More

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http://dx.doi.org/10.1080/19768354.2018.1473291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138304PMC
June 2018
13 Reads

Exploring glia to better understand Alzheimer's disease.

Anim Cells Syst (Seoul) 2018 12;22(4):213-218. Epub 2018 Aug 12.

Department of Molecular Biology, Dankook University, Cheonan, Korea.

The amyloid-β (Aβ) hypothesis has been the leading explanation for the pathogenesis of Alzheimer's disease (AD). The most common traits of AD are cognitive impairments and memory loss, which are associated with the accumulation of Aβ. Aβ aggregates activate glial cells, which in turn remove Aβ. Read More

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http://dx.doi.org/10.1080/19768354.2018.1508498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138241PMC
August 2018
11 Reads

Preference for natural borders in rice paddies by two treefrog species.

Anim Cells Syst (Seoul) 2018 1;22(3):205-211. Epub 2018 Jun 1.

Department of Life Sciences and Division of EcoScience, Ewha Womans University, Seoul, Republic of Korea.

In the Republic of Korea, one of the biggest threats to amphibians is habitat modification such as urbanisation and land conversion. With the loss of natural habitats, rice paddies play an important role as substitute habitats for amphibians that originally inhabited wetlands. However, since the 70's, traditional rice agriculture has been modernised, leading to an increase in the number of concrete ditches and roads bordering rice paddies. Read More

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http://dx.doi.org/10.1080/19768354.2018.1475301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138334PMC

VIG-1 is required for maintenance of genome stability in .

Anim Cells Syst (Seoul) 2018 24;22(3):197-204. Epub 2018 May 24.

Department of Biochemistry, College of Natural Sciences, Chungbuk National University, Cheongju, South Korea.

To explore the function of VIG-1 in , we analyzed the phenotypes of two deletion mutants: () and (). Both mutants exhibited phenotypes associated with genome instability, such as a high incidence of males (Him) and increased embryonic lethality. These phenotypes became more evident in succeeding generations, implying that the germline of accumulates DNA damage over generations. Read More

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http://dx.doi.org/10.1080/19768354.2018.1476410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138327PMC
May 2018
12 Reads

Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from .

Anim Cells Syst (Seoul) 2018 2;22(3):189-196. Epub 2018 Jun 2.

Department of Pharmacology, College of Medicine, Hallym University, Chuncheon, Korea.

The primary aim of this study was to determine whether the oral administration of AD-lico™, a functional extract from in combination with 5-aminosalicylic acid (5-ASA) could ameliorate the inflammatory symptoms in dextran sulfate sodium (DSS)-induced colitis in rodents. This DSS rodent model is used to study drug candidates for colitis, as part of the spectrum of diseases falling under the inflammatory bowel disease (IBD) category. Here, with oral AD-lico™ administration, there was a substantial disruption of the colonic architectural changes due to DSS and a significant reduction in colonic myeloperoxidase (MPO) activity, a marker of colitis. Read More

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http://dx.doi.org/10.1080/19768354.2018.1476409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138317PMC
June 2018
2 Reads

Inhibition of cell growth by cellular differentiation into adipocyte-like cells in dexamethasone sensitive cancer cell lines.

Anim Cells Syst (Seoul) 2018 18;22(3):178-188. Epub 2018 Jun 18.

Department of Biology Education, Gyeongsang National University, Jinju, Republic of Korea.

The stress responses in human body lead to secretion of cortisol hormone. The present study investigated the cellular responses on cell growth and cellular differentiation into adipocytes by exposure of synthetic stress hormone, dexamethasone (DEX) in various human cancer and normal cells. After prolonged exposure of cells with 1 μg/ml DEX for 2 weeks, population doubling time (PDT) was significantly ( < . Read More

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http://dx.doi.org/10.1080/19768354.2018.1476408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138305PMC
June 2018
0.440 Impact Factor