154 results match your criteria Animal Cells And Systems[Journal]


Identification and prevention of heterotopias in mouse neocortical neural cell migration incurred by surgical damages during utero electroporation procedures.

Anim Cells Syst (Seoul) 2020 9;24(2):114-123. Epub 2020 Mar 9.

Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University,Chuncheon, South Korea.

electroporation (IUE) is a useful technique for gene delivery in embryonic mouse brain. IUE technique is used to investigate the mammalian brain development . However, according to recent studies, IUE methodology has some limitations like the formation of artificial ectopias and heterotopias at the micro-injection site. Read More

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http://dx.doi.org/10.1080/19768354.2020.1737225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241496PMC

Knockdown of LncRNAZFAS1 suppresses cell proliferation and metastasis in non-small cell lung cancer.

Anim Cells Syst (Seoul) 2020 2;24(2):107-113. Epub 2020 Mar 2.

Department of Respiratory Medicine, HwaMei Hospital, University Of Chinese Academy Of Sciences, Ningbo, People's Republic of China.

To evaluate the effects of LncRNAZFAS1 on cell proliferation and tumor metastasis in non-small cell lung cancer (NSCLC), we detected the expression level of LncRNAZFAS1 in NSCLC-related tissues and cells. qRT-PCR results revealed that LncRNAZFAS1 in tumor tissues was significantly higher than that in normal lung tissue, especially significantly up-regulated in stage III / IV and in metastatic NSCLC tissues. LncRNAZFAS1 expression was dramatically up-regulated in 4 NSCLC-related cells (A549, SPC-A1, SK-MES-1, and NCI-H1299), with having the highest expression level in A549 cells. Read More

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http://dx.doi.org/10.1080/19768354.2020.1736623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241457PMC

Trim45 is essential to the development of the diencephalon and eye in zebrafish embryos.

Anim Cells Syst (Seoul) 2020 22;24(2):99-106. Epub 2020 Apr 22.

Department of Biological Sciences, College of Biosciences and Biotechnology, Brain Korea 21 Plus, Chungnam National University, Daejeon, South Korea.

Trim45 is one of the RING (really interesting new gene) finger containing E3 ligase, which belongs to TRIM (Tripartite motif) protein family. Its molecular biological functions have been well characterized but not in light of developmental aspects. Here, we are reporting its expression patterns and developmental functions in zebrafish embryos. Read More

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http://dx.doi.org/10.1080/19768354.2020.1751281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241540PMC

Generation of embryonic stem cells derived from the inner cell mass of blastocysts of outbred ICR mice.

Anim Cells Syst (Seoul) 2020 16;24(2):91-98. Epub 2020 Apr 16.

Department of Animal Life Science, Kangwon National University, Chuncheon, Korea.

Embryonic stem cells (ESCs) derived from outbred mice which share several genetic characteristics similar to humans have been requested for developing stem cell-based bioengineering techniques directly applicable to humans. Here, we report the generation of ESCs derived from the inner cell mass of blastocysts retrieved from 9-week-old female outbred ICR mice mated with 9-week-old male outbred ICR mice (ESCs). Similar to those from 129/Ola mouse blastocysts (ESCs), the established ESCs showed inherent characteristics of ESCs except for partial and weak protein expression and activity of alkaline phosphatase. Read More

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http://dx.doi.org/10.1080/19768354.2020.1752306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241472PMC

Hesperidin depolarizes the pacemaker potentials through 5-HT receptor in murine small intestinal interstitial cells of Cajal.

Anim Cells Syst (Seoul) 2020 26;24(2):84-90. Epub 2020 Mar 26.

Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan, Republic of Korea.

Hesperidin, a citrus flavonoid, can exert numerous beneficial effects on human health. Interstitial cells of Cajal (ICC) are pacemaker cells in the gastrointestinal (GI) tract. In the present study, we investigated potential effects of hesperidin on pacemaker potential of ICC in murine small intestine and GI motility. Read More

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http://dx.doi.org/10.1080/19768354.2020.1746398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241530PMC

Avenanthramide C suppresses hypoxia-induced cyclooxygenase-2 expression through sirtuin1 activation in non-small-cell lung cancer cells.

Anim Cells Syst (Seoul) 2020 2;24(2):79-83. Epub 2020 Apr 2.

Department of Physical Education, Inha University, Incheon, South Korea.

Avenanthramide C (AVC), found mainly in oats, mediates anti-inflammatory activities by reducing the anti-inflammatory cytokine levels. This study investigated the effects of AVC on hypoxia-induced cyclooxygenase-2 (COX-2) expression in A549 cells. AVC suppressed the hypoxia-induced increase in COX-2 protein levels and promoter activity. Read More

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http://dx.doi.org/10.1080/19768354.2020.1748108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241542PMC

JAK2-STAT5 signaling is insensitive to porcine growth hormone (pGH) in hepatocytes of neonatal pig.

Anim Cells Syst (Seoul) 2020 27;24(2):69-78. Epub 2020 Apr 27.

College of Animal Science and Technology, Jilin Agricultural University, Changchun, People's Republic of China.

Porcine growth hormone (pGH) is most important hormone which is involved in the growth and development of pig. However, a series of studies have indicated that neonatal pig is insensitive to pGH; the reason for this phenomenon is still not fully understood. In this work, we try to investigate this issue from the angle of intracellular signaling induced by pGH. Read More

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http://dx.doi.org/10.1080/19768354.2020.1735518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241498PMC

Honokiol ameliorates oxidative stress-induced DNA damage and apoptosis of c2c12 myoblasts by ROS generation and mitochondrial pathway.

Anim Cells Syst (Seoul) 2020 28;24(1):60-68. Epub 2019 Dec 28.

Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan, Republic of Korea.

Honokiol is one of the main active components of , and has been demonstrated to have multiple pharmacological activities against a variety of diseases. Recently, this phenolic compound is known to have antioxidant activity, but its mechanism of action remains unclear. The purpose of the current study was to evaluate the preventive effects of honokiol against oxidative stress-induced DNA damage and apoptosis in C2C12 myoblasts. Read More

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http://dx.doi.org/10.1080/19768354.2019.1706634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048179PMC
December 2019

SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3β activity in neuroblastoma cells.

Anim Cells Syst (Seoul) 2020 12;24(1):53-59. Epub 2020 Feb 12.

Department of Molecular Biology, Dankook University, Cheonan-si, Korea.

SIRT1, the best-characterized member of the sirtuin family of deacetylases, is involved in cancer, apoptosis, inflammation, and metabolism. Active regulator of SIRT1 (AROS) was the first identified direct regulator of SIRT1. An increasing number of reports have indicated that SIRT1 plays an important role in controlling brain tumors. Read More

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http://dx.doi.org/10.1080/19768354.2020.1726461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048222PMC
February 2020

Decursin negatively regulates LPS-induced upregulation of the TLR4 and JNK signaling stimulated by the expression of PRP4 .

Anim Cells Syst (Seoul) 2020 17;24(1):44-52. Epub 2020 Feb 17.

School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu, Korea.

The current investigation was carried out to analyze the correlation of bacterial lipopolysaccharide (LPS) and pre-mRNA processing factor 4B (PRP4) in inducing inflammatory response and cell actin cytoskeleton rearrangement in macrophages (Raw 264.7) and colorectal (HCT116) as well as skin cancer (B16-F10) cells. Cell lines were stimulated with LPS, and the expression of PRP4 as well as pro-inflammatory cytokines and proteins like IL-6, IL-1β, TLR4, and NF-κB were assayed. Read More

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http://dx.doi.org/10.1080/19768354.2020.1726811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048231PMC
February 2020
0.440 Impact Factor

Ethylparaben induces apoptotic cell death in human placenta BeWo cells via the Caspase-3 pathway.

Anim Cells Syst (Seoul) 2020 9;24(1):34-43. Epub 2020 Jan 9.

Department of Life Science, Chung-Ang University, Seoul, South Korea.

Parabens are generally used as preservatives in foods, pharmaceuticals, and various other commercial products. Among them, ethylparaben has weaker estrogenic characteristics than endogenous estrogen. However, growing evidence indicates that ethylparaben has an adverse effect on various human tissues. Read More

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http://dx.doi.org/10.1080/19768354.2020.1711804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048193PMC
January 2020

extract-induced G1 phase cell cycle arrest and apoptosis in gastric cancer cells.

Anim Cells Syst (Seoul) 2020 4;24(1):26-33. Epub 2019 Dec 4.

Department of Biomedical Science & BK21-Plus Research Team for Bioactive Control Technology, Chosun University, Gwangju, Republic of Korea.

is a traditional East Asian medicine for stomach diseases including dysentery and stomach ulcers in East Asia and has been reported to possess biological activity. The benefits of in gastric cancer are unknown. In this study, we demonstrate that extract suppresses proliferation and induces death and G1/S cell cycle arrest of gastric cancer cells. Read More

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http://dx.doi.org/10.1080/19768354.2019.1699161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048224PMC
December 2019

Autophagy inhibition in 3T3-L1 adipocytes breaks the crosstalk with tumor cells by suppression of adipokine production.

Anim Cells Syst (Seoul) 2020 8;24(1):17-25. Epub 2019 Dec 8.

Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Republic of Korea.

Several studies have revealed the functional importance of autophagy in both adipogenesis and carcinogenesis. Here, we investigated autophagy as a link between tumorigenesis and adipogenesis using 3T3-L1 cells, which have been shown to closely mimic the in vivo differentiation process. The relative levels of LC3-II/I showed that autophagy was the highest after 4-6 days of initiation of differentiation and it diminished thereafter. Read More

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http://dx.doi.org/10.1080/19768354.2019.1700159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048175PMC
December 2019

Genome editing methods in animal models.

Anim Cells Syst (Seoul) 2020 17;24(1):8-16. Epub 2020 Feb 17.

Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.

Genetically engineered animal models that reproduce human diseases are very important for the pathological study of various conditions. The development of the clustered regularly interspaced short palindromic repeats (CRISPR) system has enabled a faster and cheaper production of animal models compared with traditional gene-targeting methods using embryonic stem cells. Genome editing tools based on the CRISPR-Cas9 system are a breakthrough technology that allows the precise introduction of mutations at the target DNA sequences. Read More

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http://dx.doi.org/10.1080/19768354.2020.1726462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048190PMC
February 2020
0.440 Impact Factor

How to interpret and integrate multi-omics data at systems level.

Anim Cells Syst (Seoul) 2020 30;24(1):1-7. Epub 2020 Jan 30.

Department of Biology, Kyung Hee University, Seoul, Republic of Korea.

Current parallel sequencing technologies generate biological sequence data explosively and enable omics studies that analyze collective biological features. The more omics data that is accumulated, the more they show the regulatory complexity of biological phenotypes. This high order regulatory complexity needs systems-level approaches, including network analysis, to understand it. Read More

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http://dx.doi.org/10.1080/19768354.2020.1721321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048189PMC
January 2020
0.440 Impact Factor

Predicting climate-driven shifts in the breeding phenology of Varied Tits () in South Korean forests.

Anim Cells Syst (Seoul) 2019 10;23(6):422-432. Epub 2019 Oct 10.

Department of Forest Sciences, Seoul National University, Seoul, Republic of Korea.

Phenological shifts of plants and animals due to climate change can vary among regions and species, requiring study of local ecosystems to understand specific impacts. The reproductive timing of insectivorous songbirds in temperate forests is tightly synchronized with peak prey abundance, and thus they can be susceptible to such shift in timing. We aimed to investigate the effect of future climate change on the egg-laying phenology of the Varied Tit (), which is common and widely distributed in South Korean forests. Read More

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http://dx.doi.org/10.1080/19768354.2019.1675759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913659PMC
October 2019

Shwachman-Bodian-Diamond syndrome protein desensitizes breast cancer cells to apoptosis in stiff matrices by repressing the caspase 8-mediated pathway.

Anim Cells Syst (Seoul) 2019 20;23(6):414-421. Epub 2019 Sep 20.

Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul, Republic of Korea.

Certain cancer types, including breast cancer, are accompanied with stiffening of the surrounding extracellular matrix (ECM). Previous studies suggest that this stiffened matrix influences cancer cell progression, such as proliferation and invasion, both biochemically and mechanically. However, the contribution of ECM stiffness to cellular response to diverse stresses, which most cancer cells are exposed to, has not been elucidated. Read More

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http://dx.doi.org/10.1080/19768354.2019.1666030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913620PMC
September 2019

AEG-1 aggravates inflammation via promoting NALP3 inflammasome formation in murine endometriosis lesions.

Anim Cells Syst (Seoul) 2019 21;23(6):407-413. Epub 2019 Nov 21.

Department of Obstetrics and Gynecology, Beijing Luhe Hospital, Capital Medical University, Beijing, People's Republic of China.

Endometriosis (EMs) is one of the most common gynaecological diseases in women of childbearing age. Astrocyte elevated gene-1 (AEG-1) is associated with the invasion, migration, apoptosis and prognosis of various cancers. However, the roles of AEG-1 in EMs and its corresponding molecular mechanism are still unknown. Read More

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http://dx.doi.org/10.1080/19768354.2019.1691052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913626PMC
November 2019

Calcineurin regulates male ray development and counteracts with kinase in .

Anim Cells Syst (Seoul) 2019 16;23(6):399-406. Epub 2019 Nov 16.

Department of Life Sciences, Hanyang University, Seoul, Republic of Korea.

Phosphorylation is one of the critical protein modifications, which can lead to changing the activity of the proteins and regulating a variety of biological processes. Therefore, it is essential to properly maintain the phosphorylation level on proteins by balancing the activity of kinases and phosphatases. In this study, we report that calcineurin, a serine/threonine phosphatase, counteracts with a salt inducible kinase (SIK) to control male tail development in . Read More

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http://dx.doi.org/10.1080/19768354.2019.1687584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913648PMC
November 2019
0.440 Impact Factor

Reprogramming of spermatogonial stem cells into pluripotent stem cells in the spheroidal state.

Anim Cells Syst (Seoul) 2019 8;23(6):392-398. Epub 2019 Oct 8.

Department of Stem Cell Biology, Konkuk University School of Medicine, Seoul, Korea.

Spermatogonial stem cells (SSCs) are unipotent adult stem cells, capable of differentiating into sperm cells. SSCs can be cultured for a long time. SSCs expressing Oct4, a pluripotency marker, and are the only adult cells which pluripotency can be induced under defined culture conditions. Read More

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http://dx.doi.org/10.1080/19768354.2019.1672578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913676PMC
October 2019

Palmitate-induced autophagy liberates monounsaturated fatty acids and increases expression in hypothalamic cells.

Anim Cells Syst (Seoul) 2019 1;23(6):384-391. Epub 2019 Dec 1.

Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.

Fatty acids regulate food intake, although the exact mechanism remains unknown. Emerging evidence suggests that intracellular free fatty acids generated by starvation-induced autophagy regulate food intake. Starvation for 6 h elevated fatty acids such as palmitate, oleate, arachidonate, eicosatrienoate, and docosahexaenoate in the mouse serum. Read More

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http://dx.doi.org/10.1080/19768354.2019.1696407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913639PMC
December 2019

Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus.

Anim Cells Syst (Seoul) 2019 24;23(6):380-383. Epub 2019 Nov 24.

Department of Neuroscience, College of Medicine, Korea University, Seoul, South Korea.

Recent molecular genetic studies have suggested that two members of the cytoplasmic FMR1-interacting protein () gene family, and , are causally associated with several brain disorders. However, the clinical features of individuals with and variants are quite different. In addition, null mice for either or are lethal, indicating that these two genes cannot compensate for each other in vivo. Read More

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http://dx.doi.org/10.1080/19768354.2019.1696406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913624PMC
November 2019

Dexmedetomidine ameliorates memory impairment in sleep-deprived mice.

Anim Cells Syst (Seoul) 2019 16;23(6):371-379. Epub 2019 Nov 16.

Department of Anesthesiology and Pain Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

The selective α2-adrenergic receptor agonist dexmedetomidine acts as an analgesic, sedative, and anesthetic adjuvant. The most common consequence of sleep deprivation is memory impairment. We investigated whether dexmedetomidine can counteract memory impairment caused by sleep deprivation and suppress the production of inflammatory factors. Read More

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http://dx.doi.org/10.1080/19768354.2019.1688185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913667PMC
November 2019

Prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma.

Anim Cells Syst (Seoul) 2019 25;23(5):365-369. Epub 2019 Aug 25.

Department of Anatomy, Pusan National University School of Medicine, Yangsan, Republic of Korea.

The beta-2 adrenergic receptor (ADRB2) regulates the proliferation, apoptosis, angiogenesis, migration, and metastasis of cancer cells. However, its function in the progression of clear cell renal cell carcinoma (ccRCC) is unknown. Here, we report that ADRB2 can be a novel prognostic factor for patients with ccRCC. Read More

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http://dx.doi.org/10.1080/19768354.2019.1658638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830282PMC

Effects of eicosapentaenoic acid and docosahexaenoic acid on C2C12 cell adipogenesis and inhibition of myotube formation.

Anim Cells Syst (Seoul) 2019 3;23(5):355-364. Epub 2019 Sep 3.

Department of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville AR, USA.

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) modulate cellular metabolic functions and gene expression. This study investigated the impacts of EPA and DHA on gene expression and morphological changes during adipogenic inducement in C2C12 myoblasts. Cells were cultured and treated with differentiation medium with and without 50 μM EPA and DHA. Read More

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http://dx.doi.org/10.1080/19768354.2019.1661282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830227PMC
September 2019

Vascular endothelial growth factor improves the therapeutic effects of cyclodextrin in Niemann-Pick type C mice.

Anim Cells Syst (Seoul) 2019 25;23(5):346-354. Epub 2019 Aug 25.

KNU Alzheimer's disease Research Institute, Kyungpook National University, Daegu, Korea.

Niemann-Pick type C disease (NP-C) is a fatal neurodegenerative disorder caused by a deficiency in the function of the gene. Malfunction of this gene/protein leads to progressive accumulation of unesterified cholesterol and sphingolipids in many organs, including the brain. To date, drugs that target pivotal stages in the pathogenic cascade have been tested as monotherapies or in combination with a second agent, showing additive benefits. Read More

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http://dx.doi.org/10.1080/19768354.2019.1651768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830204PMC

Delay of cell growth and loss of stemness by inhibition of reverse transcription in human mesenchymal stem cells derived from dental tissue.

Anim Cells Syst (Seoul) 2019 13;23(5):335-345. Epub 2019 Aug 13.

Department of Biology Education, Gyeongsang National University, Jinju, Republic of Korea.

The present study investigated the cellular properties in the dental tissue-derived mesenchymal stem cells (DSCs) exposed to nevirapine (NVP), an inhibitor of reverse transcriptase (RTase). After a prolonged exposure of DSCs for 2 weeks, the population doubling time (PDT) was significantly ( < .05) increased by delayed cell growth in the DSCs treated with 250 and 500 μM NVP, compared with untreated DSCs. Read More

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http://dx.doi.org/10.1080/19768354.2019.1651767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830198PMC
August 2019
0.440 Impact Factor

HIF1α promotes prostate cancer progression by increasing ATG5 expression.

Anim Cells Syst (Seoul) 2019 28;23(5):326-334. Epub 2019 Aug 28.

The Second Affiliated Hospital & YuYing Children's Hospital of Wenzhou Medical University, Wenzhou City, People's Republic of China.

Prostate cancer (PCa) is the most frequently diagnosed cancer among men. However, the major modifiable risk factors for PCa are poorly known and its specific mechanism of progression remains unclear. Here we reported that, in prostate cancer cells, the autophagy level was elevated under hypoxic condition, as well as the mRNA and protein level of ATG5, which is an important gene related to autophagy. Read More

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http://dx.doi.org/10.1080/19768354.2019.1658637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830197PMC

Endogenous leptin promotes autophagy in EBSS-induced PFCs.

Anim Cells Syst (Seoul) 2019 16;23(5):318-325. Epub 2019 Aug 16.

Key Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Kunming, People's Republic of China.

Leptin is an important adipokine and plays a vital role in animals. However, the role of leptin in the autophagic response of pig fibroblast cells (PFCs) has not been fully elucidated. In this study, we investigated the relationship between leptin and autophagy as well as underlying molecular basis. Read More

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http://dx.doi.org/10.1080/19768354.2019.1651766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830286PMC

Ubiquitin-specific peptidase 3 induces TPA-mediated leukemia cell differentiation via regulating H2AK119ub.

Anim Cells Syst (Seoul) 2019 6;23(5):311-317. Epub 2019 Sep 6.

Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul, South Korea.

Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Owing to the chemotherapy associated side effects and toxicity, it is necessary to find a new mechanism, which can identify new potential therapeutic targets at the molecular level. Here, we identified new target genes that are induced during the TPA-induced HL-60 cell differentiation by ChIP-seq and microarray data analysis. Read More

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http://dx.doi.org/10.1080/19768354.2019.1661283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830191PMC
September 2019

Metformin inhibits cervical cancer cell proliferation via decreased AMPK O-GlcNAcylation.

Anim Cells Syst (Seoul) 2019 14;23(4):302-309. Epub 2019 May 14.

Gyeongsang National University, Jinju, The Republic of Korea.

Metformin is a widely used drug for the treatment of type 2 diabetes. Antidiabetic drugs are also known to influence cancer progression, as high glucose levels affect both cancer and diabetes. Metformin induces cell cycle arrest in cancer cells, but the underlying mechanism remains unclear in cervical cancer system. Read More

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http://dx.doi.org/10.1080/19768354.2019.1614092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711131PMC

Anoctamin-1 affects the migration and invasion of anaplastic thyroid carcinoma cells.

Anim Cells Syst (Seoul) 2019 10;23(4):294-301. Epub 2019 May 10.

Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea.

Anaplastic thyroid carcinoma (ATC) is a rare malignancy with very poor prognosis. The exact cause underlying its strong aggressive nature is not clear. Here, we discovered the elevated expression of anoctamin-1 (ANO1; Ca-activated Cl channels) in advanced-stage ATC tissue. Read More

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https://www.tandfonline.com/doi/full/10.1080/19768354.2019.1
Publisher Site
http://dx.doi.org/10.1080/19768354.2019.1614981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711113PMC
May 2019
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Paternal bias expression of Igf2as is enhancer-dependent on the imprinting cluster of Igf2, H19 and Nctc1 in muscle cells.

Anim Cells Syst (Seoul) 2019 16;23(4):288-293. Epub 2019 May 16.

Core-Laboratory for Convergent Translational Research, Korea University College of Medicine, Seoul, South Korea.

Igf2, H19, and Nctc1 are linked co-regulated genes on distal mouse chromosome 7. This locus is an important model both for studying mechanisms of monoallelic expression and for elucidating the role of cis-regulatory elements - enhancers and insulators - in organizing chromatin and gene expression across a large domain. In this study we characterize regulated expression of the Igf2 antisense transcript (Igf2as) in primary muscle cells. Read More

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http://dx.doi.org/10.1080/19768354.2019.1612780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711144PMC

Comparative analysis of three different protocols for cholinergic neuron differentiation in vitro using mesenchymal stem cells from human dental pulp.

Anim Cells Syst (Seoul) 2019 10;23(4):275-287. Epub 2019 Jun 10.

Department of Theriogenology and Biotechnology, College of Veterinary Medicine and Research Institute of Life Science, Gyeongsang National University, Jinju, Republic of Korea.

A decrease in the activity of choline acetyltransferase, the enzyme responsible for acetylcholine synthesis in the cholinergic neurons cause neurological disorders involving a decline in cognitive abilities, such as Alzheimer's disease. Mesenchymal stem cells (MSCs) can be used as an efficient therapeutic agents due to their neuronal differentiation potential. Different source derived MSCs may have different differentiation potential under different inductions. Read More

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http://dx.doi.org/10.1080/19768354.2019.1626280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711138PMC

Transcriptome analyses suggest minimal effects of Shank3 dosage on directional gene expression changes in the mouse striatum.

Anim Cells Syst (Seoul) 2019 12;23(4):270-274. Epub 2019 Apr 12.

Department of Neuroscience, College of Medicine, Korea University, Seoul, South Korea.

Both deletions and duplications of the SH3 and multiple ankyrin repeat domains 3 () gene, encoding excitatory postsynaptic scaffolds, are causally associated with various brain disorders, suggesting that proper Shank3 dosage is critical for normal brain development and function. In addition to its well-established synaptic functions, recent studies have suggested that Shank3 can also affect gene expression in the nucleus. However, it has not been investigated whether there are a group of genes whose directional expression is regulated in a Shank3 dosage-dependent manner (i. Read More

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http://dx.doi.org/10.1080/19768354.2019.1595142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711111PMC

Long-term exposure to moderate noise induces neural plasticity in the infant rat primary auditory cortex.

Anim Cells Syst (Seoul) 2019 19;23(4):260-269. Epub 2019 Jul 19.

Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai, People's Republic of China.

Previous studies have reported that rearing infant rat pups in continuous moderate-level noise delayed the formation of topographic representational order and the refinement of response selectivity in the primary auditory (A1) cortex. The present study further verified that exposure to long-term moderate-intensity white noise (70 dB sound pressure level) from postnatal day (P) 12 to P30 elevated the hearing thresholds of infant rats. Compared with age-matched control rats, noise exposure (NE) rats had elevated hearing thresholds ranging from low to high frequencies, accompanied by decreased amplitudes and increased latencies of the two initial auditory brainstem response waves. Read More

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http://dx.doi.org/10.1080/19768354.2019.1643782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711034PMC

KAT5 Negatively regulates the proliferation of prostate cancer LNCaP cells via the caspase 3-dependent apoptosis pathway.

Anim Cells Syst (Seoul) 2019 1;23(4):253-259. Epub 2019 Aug 1.

Department of Life Science, Chung-Ang University, Seoul, Republic of Korea.

Prostate cancer is one of the most common cancers in men over the age of sixty. Lysine acetyltransferase 5 (KAT5) is a histone acetyltransferase involved in transcriptional regulation, DNA repair, and cell signaling pathways. Previous studies have shown that KAT5 expression is reduced in the cytoplasm of the prostate cancer cell line LNCaP when exposed to androgen. Read More

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http://dx.doi.org/10.1080/19768354.2019.1644372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711033PMC

Effects of resveratrol and oxyresveratrol on hippocampal cell death induced by kainic acid.

Anim Cells Syst (Seoul) 2019 31;23(4):246-252. Epub 2019 May 31.

Department of Pharmacology, Institute of Natural Medicine, College of Medicine Hallym University, Chuncheon, Republic of Korea.

In the present study, we have examined the possible neuroprotective effects of resveratrol and oxyresveratrol against kainic-acid (KA)-induced hippocampal neuronal cell death. Either resveratrol or oxyresvertrol was orally administered 30 min prior to intracerebroventricular (i.c. Read More

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http://dx.doi.org/10.1080/19768354.2019.1620853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711029PMC

PRDX6 regulates the H2O2 and blue light-induced APRE-19 cell apoptosis via down-regulating and interacting with RARA.

Anim Cells Syst (Seoul) 2019 11;23(4):241-245. Epub 2019 Apr 11.

Department of the Ophthalmology, Second Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.

Hereditary retinal disease (HRD) is the primary retinal degeneration that leads to severe visual impairments and refractory blindness, and the therapy of HRD was most important in ophthalmology. The apoptosis of retinal cells plays important roles in HRD progression. Therefore, in this study, we explore the mechanism of H2O2 and blue light-induced apoptosis of ARPE-19 cells. Read More

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http://dx.doi.org/10.1080/19768354.2019.1592021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711153PMC

Low breeding success of the little egret () near residential areas and in colonies exposed to gales: a comparison of colony in Sichuan, Southwest China, with literature.

Anim Cells Syst (Seoul) 2019 Jun 26;23(3):235-240. Epub 2019 Mar 26.

College of Agriculture and Natural Resources, University of Maryland, College Park, MD, USA.

The breeding biology of the little egret () was studied in 20 nests within the mixed-species breeding colonies at Nanchong, Sichuan, Southwest China, in 2006. By measuring a set of physical characteristics of vegetation at the nests and at a set of 20 randomly chosen sites we showed that birds preferentially used taller trees in areas with fewer shrubs of higher species diversity. Nests at lower locations in trees had marginally lower hatching success due to their destruction by humans; this destruction contributed marginally significantly to lowering of the total nesting success in all studied nests. Read More

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http://dx.doi.org/10.1080/19768354.2019.1596980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567181PMC
June 2019
15 Reads

What is the taxonomic status of East Asian otter species based on molecular evidence?: focus on the position of the Japanese otter holotype specimen from museum.

Anim Cells Syst (Seoul) 2019 Jun 2;23(3):228-234. Epub 2019 May 2.

Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.

The Japanese otter (), once inhabited in most islands of Japan, is now considered as an extinct species. Although the Japanese otter is regarded as a distinct species from the Eurasian otter (), its phylogeny and taxonomic status are based on limited information on morphological and genetic data, and thus further clarification is required. Here, we assessed the phylogenetic relationship among the genus and taxonomic status of by using the complete sequences of cytochrome gene of its holotype. Read More

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http://dx.doi.org/10.1080/19768354.2019.1601133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567078PMC
June 2019
2 Reads

A proteomic analysis of differentiating dopamine neurons derived from human embryonic stem cells.

Anim Cells Syst (Seoul) 2019 Jun 11;23(3):219-227. Epub 2019 Apr 11.

Department of Bio and Environmental Technology, Seoul Women's University, Seoul, Korea.

Human embryonic stem cells (hESC) are being exploited for potential use in cell transplantation due to their capacity for self-renewal and pluripotency. Dopamine (DA) neurons derived from hESC represent a promising source of cell replacement therapy for Parkinson's disease (PD). While gene expression on the transcriptome level has been extensively studied, limited information is available for the proteome-level changes associated with DA neuron differentiation. Read More

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http://dx.doi.org/10.1080/19768354.2019.1595140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566932PMC
June 2019
11 Reads

Zebrafish model of -initiated pancreatic endocrine tumor.

Anim Cells Syst (Seoul) 2019 Jun 10;23(3):209-218. Epub 2019 May 10.

Division of Life Sciences, Incheon National University, Incheon, Republic of Korea.

Pancreatic cancer constitutes a genetic disease in which somatic mutations in the proto-oncogene are detected in 95% of cases. Activation of the KRAS proto-oncogene represents an initiating event in pancreatic tumorigenesis. Here, we established a zebrafish pancreatic neoplasia model that recapitulates human pancreatic tumors. Read More

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http://dx.doi.org/10.1080/19768354.2019.1610058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566937PMC
June 2019
7 Reads
0.440 Impact Factor

Photoperiod may regulate growth via leptin receptor A1 in the hypothalamus and saccus vasculosus of Atlantic salmon ().

Anim Cells Syst (Seoul) 2019 Jun 12;23(3):200-208. Epub 2019 Apr 12.

Institute of Oceanology Chinese Academy of Sciences, Qingdao, People's Republic of China.

Photoperiod is believed to regulate growth in fish, although the mechanism involved is still unclear. In this paper, we report a relationship between leptin-receptor A1 (), melatonin-receptor () and photoperiod in Atlantic salmon. Atlantic salmon (mean weight 1071. Read More

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http://dx.doi.org/10.1080/19768354.2019.1595138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566995PMC
June 2019
17 Reads

Histone deacetylase 6 interference protects mice against experimental stroke-induced brain injury via activating Nrf2/HO-1 pathway.

Anim Cells Syst (Seoul) 2019 Jun 18;23(3):192-199. Epub 2019 Apr 18.

Department of Neurology, Affiliated Yixing Hospital of Jiangsu University/Affiliated Yixing Clinical School of Medical School of Yangzhou University, Yixing, Jiangsu Province, Peoples' Republic of China.

Cerebral stroke is a fatal disease with increasing incidence. The study was to investigate the role and mechanism of Histone deacetylase 6 (HDAC6) on experimental stroke-induced brain injury. The recombinant shRNA-HDAC6 or scramble shRNA lentivirus was transfected to ICR mice. Read More

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http://dx.doi.org/10.1080/19768354.2019.1601132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566595PMC
June 2019
22 Reads
0.440 Impact Factor

TLR4-dependent effects of ISAg treatment on conventional T cell polarization .

Anim Cells Syst (Seoul) 2019 Jun 25;23(3):184-191. Epub 2019 Apr 25.

Department of Life Science and Multidisciplinary Genome Institute, Hallym University, Chuncheon, Korea.

We recently demonstrated that the polysaccharide component of the Korean medicinal herb (immuno-stimulatory fraction of ; ISAg) induces anticancer effects in mice by activating natural killer (NK) and natural killer T (NKT) cells. However, it is unclear whether the use of ISAg can affect the differentiation of conventional T cells. Here, we investigated the effects of ISAg on the activation of conventional CD4 and CD8 T cells. Read More

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http://dx.doi.org/10.1080/19768354.2019.1610059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566868PMC
June 2019
20 Reads

Buforin IIb induced cell cycle arrest in liver cancer.

Authors:
Dan Li Yong Xu

Anim Cells Syst (Seoul) 2019 Jun 26;23(3):176-183. Epub 2019 Apr 26.

Blood Purification Center, The Third Xiangya Hospital of Central South University, Changsha, People's Republic of China.

The inhibitory effect of buforin IIb on different types of cancer, although not liver cancer, has been demonstrated previously. The aim of the present study was to investigate the effects of buforin IIb on the progression of liver cancer. The human liver cancer cell line HepG2 was treated with purified buforin IIb and the cell activity was determined by MTT, colony formation and transwell assays. Read More

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http://dx.doi.org/10.1080/19768354.2019.1595139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566800PMC
June 2019
12 Reads

Endothelin-converting enzyme-1 expression in acute and chronic liver injury in fibrogenesis.

Anim Cells Syst (Seoul) 2019 Jun 9;23(3):170-175. Epub 2019 Jun 9.

Labratory of Developmental Biology and Stem Cell Differentiation/Transplantation, Department of Dental Regenerative Biotechnology, School of Dentistry, Seoul National University South Korea, Seoul, South Korea.

Endothelin-1 (ET-1) induces contraction, proliferation, and collagen synthesis of activated hepatic stellate cells and is a potent mediator of portal hypertension. Endothelin-converting enzyme-1 (ECE-1) generates ET-1 from the inactive precursor big-endothelin-1. The cellular distribution and activity of ECE-1 in the liver is unknown. Read More

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http://dx.doi.org/10.1080/19768354.2019.1595141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566842PMC
June 2019
17 Reads

Novel GFP-fused protein probes for detecting phosphatidylinositol-4-phosphate in the plasma membrane.

Anim Cells Syst (Seoul) 2019 Jun 11;23(3):164-169. Epub 2019 Apr 11.

Department of Ecological Science, College of Ecology and Environment, Kyungpook National University, Sangju-si, Republic of Korea.

Phosphatidylinositol-4-phosphate (PI4P) plays a crucial role in cellular functions, including protein trafficking, and is mainly located in the cytoplasmic surface of intracellular membranes, which include the trans-Golgi network (TGN) and the plasma membrane. However, many PI4P-binding domains of membrane-associated proteins are localized only to the TGN because of the requirement of a second binding protein such as ADP-ribosylation factor 1 (ARF1) in order to be stably localized to the specific membrane. In this study, we developed new probes that were capable of detecting PI4P at the plasma membrane using the known TGN-targeting PI4P-binding domains. Read More

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http://dx.doi.org/10.1080/19768354.2019.1599424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567041PMC
June 2019
9 Reads

Pharmacokinetic, metabolic stability, plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors.

Anim Cells Syst (Seoul) 2019 Jun 16;23(3):155-163. Epub 2019 May 16.

Department of Pharmacy, Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.

N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide (NHPPC) is a new potential of type 5 phosphodiesterase (PDE5) inhibitors, synthesized from the avanafil analogue for the treatment of erectile dysfunction. The targets of this article were to assess plasma protein binding, liver microsomal metabolic stability, inhibition and induction on cytochrome P450 isozymes and the pharmacokinetics of NHPPC. Equilibrium dialysis technique was applied to determine Plasma protein binding (PPB) and NHPPC was evaluated in male Sprague-Dawley rats and Beagle dogs in vivo pharmacokinetic. Read More

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http://dx.doi.org/10.1080/19768354.2019.1614091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567057PMC
June 2019
12 Reads