9,999 results match your criteria Angiosarcoma

Diagnosis of metastatic angiosarcoma of the aorta in colonic lesion biopsies.

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

UGC de Aparato Digestivo, Hospital Universitario Virgen del Rocío, ESPAÑA.

Angiosarcomas are rare tumors that usually entail a poor prognosis because of extensive invasiveness and high rates of distant metastasis. Gastrointestinal tract involvement is uncommon but may cause digestive bleeding. A definitive diagnosis requires histological and immunohistochemical testing. Read More

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Chemotherapy in patients with localized angiosarcoma of any site: A retrospective european study.

Eur J Cancer 2022 Jun 18;171:183-192. Epub 2022 Jun 18.

Pathology Department, University Hospital of Canary Islands, Canary Islands, Spain.

Background: We retrospectively investigated the role of (neo)adjuvant chemotherapy in patients with primary, localized angiosarcoma.

Methods: We selected all patients with primary, localized angiosarcoma, who had received radical surgery between January 2005 and December 2019 at 33 European sarcoma reference centers. The primary objective was to compare the outcome of patients who received (neo)adjuvant chemotherapy versus those who did not, in terms of overall survival (OS), disease-free survival (DFS) and distant metastasis-free survival (DMFS). Read More

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A mouse model for Li-Fraumeni-Like Syndrome with cardiac angiosarcomas associated to POT1 mutations.

PLoS Genet 2022 Jun 21;18(6):e1010260. Epub 2022 Jun 21.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.

The shelterin protein POT1 has been found mutated in many different familial and sporadic cancers, however, no mouse models to understand the pathobiology of these mutations have been developed so far. To address the molecular mechanisms underlying the tumorigenic effects of POT1 mutant proteins in humans, we have generated a mouse model for the human POT1R117C mutation found in Li-Fraumeni-Like families with cases of cardiac angiosarcoma by introducing this mutation in the Pot1a endogenous locus, knock-in for Pot1aR117C. We find here that both mouse embryonic fibroblasts (MEFs) and tissues from Pot1a+/ki mice show longer telomeres than wild-type controls. Read More

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Primary central nervous system angiosarcoma with recurrent acute subdural hematoma.

Neurocirugia (Astur : Engl Ed) 2022 Jul-Aug;33(4):199-203

Department of Neurosurgery, Hospital General Universitario Gregorio Marañón, Calle Doctor Esquerdo 46, 28007 Madrid, Spain.

Angiosarcoma is an infrequent tumor among sarcomas, especially presenting as a primary tumor within the central nervous system, which can lead to a rapid neurological deterioration and death in few months. We present a 41-year old man with a right frontal enhancing hemorrhagic lesion. Surgery was performed with histopathological findings suggesting a primary central nervous system angiosarcoma. Read More

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Epithelioid angiosarcoma of the masseter muscle: a rare clinicopathological diagnosis.

Med Pharm Rep 2022 Jan 31;95(1):92-96. Epub 2022 Jan 31.

Focus Imaging and Research Centre Pvt Ltd-Laboratory Medicine Division, New Delhi, India.

Epithelioid angiosarcoma (EA) is a subtype of angiosarcoma which is a rare tumor of endothelial origin. Here, we report a case of 15-year-old boy who presented with soft tissue mass lesion in the parotid region mimicking as a benign parotid tumor. Cytology was suggestive of inflammatory swelling. Read More

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January 2022

Dosimetric Superiority of High-Dose-Rate (HDR) Brachytherapy Using a Surface Mold Applicator for Primary Cutaneous Angiosarcoma of the Scalp.

Cureus 2022 May 16;14(5):e25056. Epub 2022 May 16.

Department of Radiology, Tokyo Medical University, Tokyo, JPN.

The aim of this study was to demonstrate the utility of the dose-volume parameters of the target lesions and the radiation dose to the organ at risk (OAR) in two patients with primary cutaneous angiosarcoma of the scalp (CAS) treated with high-dose-rate brachytherapy (HDR-BT) using a surface mold applicator. In 2020, two men, aged 80 years and 60 years, respectively, were treated with HDR-BT with paclitaxel for CAS with no distant metastases and no surgical indication at our institution. The total irradiated dose was 57 Gy administered in daily fractions of 3 Gy four days per week. Read More

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Innovative approach to lymphadenectomy in breast sarcoma.

Bull Cancer 2022 Jun 15. Epub 2022 Jun 15.

ICANS (Strasbourg Europe), Surgery Department, 17, rue Albert Calmette, 67033 Strasbourg, France; University of Strasbourg, Institute of Genetics and Molecular and Cellular Biology CNRS UMR 7104, INSERM U964, 67400 Illkirch, France. Electronic address:

Lymphatic dissemination is thought to be a rare event in breast sarcomas. The decision to perform axillary clearance is challenging. In our prospective cohort, we aimed to evaluate the frequency and factors determining lymph node (LN) involvement in breast sarcomas, with the aim of proposing a decision tree/algorithm for the realization of LN clearance in breast sarcomas. Read More

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Management of Skin Sarcomas.

Surg Oncol Clin N Am 2022 Jul 31;31(3):511-525. Epub 2022 May 31.

Sarcoma Service - Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, Milan 20133, Italy. Electronic address:

Skin sarcomas are tumors that are superficial and small in size in comparison with other sarcomas arising in intramuscular or intrabdominal sites. Skin sarcomas are often underrecognized and misdiagnosed. A high level of suspicion is needed, as early recognition and appropriate management including initial surgery is important for oncologic outcomes. Read More

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Management of Vascular Sarcoma.

Surg Oncol Clin N Am 2022 Jul;31(3):485-510

Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.

Vascular sarcomas encompass 3 well-defined sarcoma types: hemangioendothelioma, Kaposi sarcoma, and angiosarcoma. These distinct types are exceedingly rare and very different in terms of clinical behavior, biological features, and treatment approach. Because of this rarity and heterogeneity, it is crucial that vascular sarcomas are treated in sarcoma reference centers or networks, in order to ensure optimal management. Read More

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Immunotherapy in Sarcoma: Where Do Things Stand?

Surg Oncol Clin N Am 2022 Jul;31(3):381-397

Department of Medical Oncology, Centre Leon Berard, 28 rue Laennec, Lyon 69008, France.

Early experiences with modern immunotherapy have been disappointing in trials of unselected sarcoma subtypes. However, remarkable efficacy has been observed with immune checkpoint inhibitors (ICIs) in a subset of patients, with the most promising outcomes to date in alveolar soft part sarcoma, cutaneous angiosarcoma, undifferentiated pleomorphic sarcoma (UPS), and dedifferentiated liposarcoma (dLPS). Adoptive cellular therapies targeting cancer testis antigens have shown promising activity, but only synovial sarcoma (SS) and myxoid/round cell liposarcomas reliably express these targets. Read More

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Composite reconstruction of right ventricle and tricuspid valve for cardiac angiosarcoma.

JTCVS Tech 2022 Jun 18;13:67-69. Epub 2022 Apr 18.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

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Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma.

Nat Commun 2022 Jun 16;13(1):3477. Epub 2022 Jun 16.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.

PD-1 blockade (nivolumab) efficacy remains modest for metastatic sarcoma. In this paper, we present an open-label, non-randomized, non-comparative pilot study of bempegaldesleukin, a CD122-preferential interleukin-2 pathway agonist, with nivolumab in refractory sarcoma at Memorial Sloan Kettering/MD Anderson Cancer Centers (NCT03282344). We report on the primary outcome of objective response rate (ORR) and secondary endpoints of toxicity, clinical benefit, progression-free survival, overall survival, and durations of response/treatment. Read More

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Third-degree atrioventricular block secondary to infiltrative cardiac hemangiosarcoma in a dog.

J Vet Cardiol 2022 May 18;42:43-46. Epub 2022 May 18.

Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Rd, North Grafton, MA 01536, USA.

A nine-year-old male, castrated Pembroke Welsh Corgi presented with a two-month history of lethargy, hyporexia, and occasional vomiting. There was also a two-week history of exercise intolerance; no syncopal episodes were reported. Auscultation revealed bradycardia with an irregular rhythm and otherwise normal heart and lung sounds. Read More

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Imaging Findings and Clinical Features of Primary Spinal Epithelioid Hemangioendothelioma.

Front Oncol 2022 30;12:713947. Epub 2022 May 30.

Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Rationale And Objectives: Primary spinal epithelioid hemangioendothelioma (SEHE) is an extremely rare angiocentric vascular neoplasm with inherent metastatic potential, which pursues a clinical course intermediate between hemangioma and angiosarcoma. The present study sought to present computed tomography (CT) and magnetic resonance imaging (MRI) findings and clinical features of primary SEHE and review the literature.

Materials And Methods: Clinical data of four patients with primary SEHE confirmed by pathology from January 2011 to May 2020 were analyzed retrospectively. Read More

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Clinical and Pathologic Characterization of 94 Radiation-Associated Sarcomas: Our Institutional Experience.

Int J Surg Pathol 2022 Jun 12:10668969221105626. Epub 2022 Jun 12.

Department of Laboratory Medicine and Pathology, 7284University of Washington, Seattle, WA, USA.

Radiation-associated sarcomas are an uncommon complication of therapeutic radiation. However, their prevalence has increased with the more widespread use of this treatment modality. The clinical, pathologic and genetic characteristics of radiation-associated sarcomas are not fully understood. Read More

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Angiosarcoma and Vascular Surgery A Case Report and Review of the Literature to Focus on a Possible Risk Factor.

Vasc Endovascular Surg 2022 Jun 11:15385744221108248. Epub 2022 Jun 11.

Dermatology Unit, 198202Ospedale San Bortolo, Vicenza, Italy.

Introduction: Angiosarcomas (AS) are rare and aggressive neoplasms originating from the endothelium: they represent less than 2% of all soft tissue sarcomas and usually have a poor prognosis. Although more often primary, different risk factors have been described and some cases are associated with vascular surgery. We present the case of an 84-year-old man who developed an AS on his thigh 3 years after a popliteal bypass with autologous saphenous vein. Read More

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Liver Resection for Primary Hepatic Angiosarcoma: Bicentric Analysis of a Challenging Entity.

J Clin Med 2022 May 25;11(11). Epub 2022 May 25.

Department for General, Visceral, and Transplant Surgery, University Hospital Muenster, 48149 Muenster, Germany.

Primary hepatic angiosarcoma (PHA) is a rare malignant tumor of the liver, and data on patient outcome after surgical treatment are scarce. The aim of this study was to evaluate postoperative morbidity and overall survival (OS) of patients who underwent hepatectomy for PHA. This is a bicentric retrospective analysis of all consecutive patients who underwent liver resection in curative intent for PHA between 2012 and 2019 at the University Hospital of Muenster and the University Hospital of Bern. Read More

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Cohort profile: The Golden Retriever Lifetime Study (GRLS).

PLoS One 2022 9;17(6):e0269425. Epub 2022 Jun 9.

Scientific Programs Department, Morris Animal Foundation, Denver, Colorado, United States of America.

The aim of this article is to provide a detailed description of the Golden Retriever Lifetime Study (GRLS), a prospective cohort study investigating nutritional, environmental, lifestyle, and genetic risk factors for cancer and other common diseases in dogs. Primary outcomes of interest include hemangiosarcoma, lymphoma, osteosarcoma, and high-grade mast cell tumors. Secondary outcomes of interest include other cancers, hypothyroidism, epilepsy, atopy, otitis externa, hip dysplasia, heart failure, and renal failure. Read More

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Anastomosing hemangioma: a current update on clinical, pathological and imaging features.

Abdom Radiol (NY) 2022 Jul 9;47(7):2335-2346. Epub 2022 Jun 9.

Department of Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1473, Houston, TX, 77030, USA.

Anastomosing hemangioma (AH) is a rare, benign vascular neoplasm with distinctive histopathology and characteristic tumor distribution. AHs show marked proclivity to involve the kidneys, gonads and the retroperitoneal soft tissues; kidney is the most common target site often in the context of end stage renal disease. Recent studies have identified activating mutations of GNA genes that drive the molecular pathogenesis of AHs. Read More

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A rare presentation of pregnancy associated primary angiosarcoma of the breasts.

Radiol Case Rep 2022 Aug 1;17(8):2708-2713. Epub 2022 Jun 1.

Division of Breast Imaging, Department of Radiology, Breast Imaging Fellowship Program, UNC School of Medicine, Chapel Hill, NC.

Primary angiosarcoma of the breast is a rare malignancy that is important for radiologists to recognize in young patients because its imaging appearance may mimic benign lesions resulting in advanced stages of disease and overall decreased patient survival. We present a unique case of a bilateral primary angiosarcoma in a pregnant patient in her twenties. She presented with a self-detected, rapidly enlarging, non-tender right breast mass while in her third trimester. Read More

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Multimodality Imaging for Pericardial Epithelioid Angiosarcoma Presenting With Pericardial Effusion and Constrictive Pericarditis.

Korean Circ J 2022 May 17. Epub 2022 May 17.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

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Primary splenic angiosarcoma. An aggressive and infrequent pathology.

Rev Esp Enferm Dig 2022 Jun 3. Epub 2022 Jun 3.

HLA. La Inmaculada.

Splenic angiosarcoma is a very rare and aggressive neoplasm originating from the splenic vascular endothelium whose prognosis is very poor despite surgical treatment. Preoperative diagnosis using imaging tests is a challenge due to its similarity to other vascular splenic tumors. The most common treatment is splenectomy, although it is rarely curative because of the aggressive and metastatic nature of the disease. Read More

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Primary hepatic angiosarcoma manifesting as hepatic sinusoidal obstruction syndrome: A case report.

World J Gastrointest Oncol 2022 May;14(5):1050-1056

The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China.

Background: Primary hepatic angiosarcoma (PHA) is a rare malignancy with a poor prognosis. It is difficult to diagnose PHA because of the lack of specific symptoms or tumour markers, and it rapidly progresses and has a high mortality. To our knowledge, PHA has not been reported to mimic hepatic sinusoidal obstruction syndrome. Read More

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Angiosarcoma of the aorta diagnosed with endoscopic ultrasound.

Rev Esp Enferm Dig 2022 May 31. Epub 2022 May 31.

Aparato Digestivo, Hospital Clínico Universitario de Salamanca, España.

A 54-year-old man consulted for low back pain of 5 weeks of evolution, refractory to regular analgesics, and significant weight loss. The PET-CT revealed a retroperitoneal mass in contact with the anterior wall of the abdominal aorta. After consulting with the Endoscopy Unit, an endoscopic ultrasound-guided FNAP was performed due to the accessibility of the lesion and the less invasive nature of these procedures. Read More

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Gene expression profiles of beta-adrenergic receptors in canine vascular tumors: a preliminary study.

BMC Vet Res 2022 May 30;18(1):206. Epub 2022 May 30.

Department of Animal Medicine and Surgery, Universitat Autònoma de Barcelona, 08193, Barcelona, Spain.

Beta adrenergic receptors (β-AR) play a key role in regulating several hallmark pathways of both benign and malignant human and canine tumors. There is scarce information on the expression of β-AR in canine vascular tumors. Therefore, the purpose of the present research work was to study the mRNA expression levels of the three subtypes of the β-AR genes (ADRB1, ADRB2, ADRB3) in hemangiosarcoma (HSA) and hemangioma (HA), as well as in vascular hamartomas (VH) from dogs. Read More

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Treatment Outcomes for Primary Hepatic Angiosarcoma: National Cancer Database Analysis 2004-2014.

Curr Oncol 2022 05 17;29(5):3637-3646. Epub 2022 May 17.

Seidman Cancer Center, University Hospitals, Cleveland, OH 44106, USA.

Background: To determine the risk of mortality and factors associated with survival amongst patients diagnosed with primary hepatic angiosarcoma (PHA).

Methods: All patients diagnosed with hepatocellular carcinoma (HCC) or PHA from 2004 to 2014 were identified from the National Cancer Database (NCDB). Further analysis was performed within the cohort of patients with PHA to assess the impact of surgery, chemotherapy, radiation, and facility type on overall survival (OS). Read More

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Primary Angiosarcoma of the Breast: A Single-Center Retrospective Study in Korea.

Curr Oncol 2022 05 4;29(5):3272-3281. Epub 2022 May 4.

Division of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Due to the rarity of primary angiosarcoma of the breast, optimal management is based on expert opinion. The aim of this study was to review all primary angiosarcomas of the breast obtained from a single center in terms of clinicopathologic characteristics, treatment, and survival outcomes. From 1997 to 2020, 15 patients with primary angiosarcoma of the breast underwent either mastectomy or wide excision. Read More

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Angiosarcoma of breast and chest wall complicated with tuberculous empyema: A case report.

Thorac Cancer 2022 May 26. Epub 2022 May 26.

Thoracic Surgery Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China.

Angiosarcoma is a highly malignant endothelial tumor, accounting for 1% to 2% of soft tissue sarcomas. The most common site of the disease is the skin, accounting for approximately 60% of cases, especially the skin of the head. It can also occur in soft tissue, bone, and retroperitoneum. Read More

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Non-alpine primary thyroid angiosarcoma.

Arch Endocrinol Metab 2022 May 25. Epub 2022 May 25.

Departamento de Endocrinologia, Hospital Beatriz Ângelo, Loures, Portugal.

Thyroid angiosarcoma is an extremely rare malignancy, which occurs more frequently in the alpine region, likely associated with iodine deficiency and endemic goiter. This is an aggressive neoplasm that usually harbors a poor prognosis. We report the case of a 49-year-old Portuguese female patient presenting with a large nodule in the anterior neck region, with rapid growth and associated dysphonia. Read More

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