9,222 results match your criteria Angiosarcoma


Angiosarcoma heterogeneity and potential therapeutic vulnerability to immune checkpoint blockade: insights from genomic sequencing.

Genome Med 2020 Jul 9;12(1):61. Epub 2020 Jul 9.

Center for Personalized Cancer Therapy, University of California, Moores Cancer Center, La Jolla, CA, 92093, USA.

Background: Angiosarcoma is an aggressive tumor. Recent case series describe exceptional responses to checkpoint blockade in this disease.

Methods: Herein, we explored the genomic correlates of 48 angiosarcomas from the Angiosarcoma Project (12,499 variants analyzed in 6603 genes; whole-exome sequencing) versus 10,106 pan-cancer tumors in The Cancer Genome Atlas including 235 sarcomas but no angiosarcoma. Read More

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http://dx.doi.org/10.1186/s13073-020-00753-2DOI Listing

Acute progressing hepatic angiosarcoma: An autopsy case report.

Radiol Case Rep 2020 Aug 29;15(8):1403-1407. Epub 2020 Jun 29.

Department of Gastroenterology and Hepatology, Graduate school of Medicine, Hokkaido University, kita 14-jo nishi 5-chome kita-ku, Sapporo 060-8648, Japan.

A man in his 50s presented with pitting edema of both lower legs and abdominal distension as his chief complaint. His personal medical history and family history were unremarkable, except that he was a heavy drinker consuming 66 g of alcohol per day and a heavy smoker. Blood tests upon admission showed slight hepatic dysfunction, thrombocytopenia, jaundice, hypoalbuminemia, and decreased coagulability. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329938PMC

Evaluation of intrinsic and extrinsic risk factors for dog visceral hemangiosarcoma: A retrospective case-control study register-based in Lazio region, Italy.

Prev Vet Med 2020 Jun 20;181:105074. Epub 2020 Jun 20.

Istituto Zooprofilattico Sperimentale Del Lazio e Della Toscana "M.Aleandri", via Appia Nuova 1411, 00178, Rome, Italy.

The genetic and breed susceptibility of visceral hemangiosarcoma in dogs has been studied, but there is no evidence of environmental risk factors as reported in human medicine. We conducted a case-control study in which the sampling population was the list of canine oncology cases of the Animal Tumour Registry of Lazio region, Italy (2009-2017). We defined cases as dogs with visceral hemangiosarcoma and controls as dogs affected by another neoplasm. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2020.105074DOI Listing

Bispecific Targeting of EGFR and Urokinase Receptor (uPAR) Using Ligand-Targeted Toxins in Solid Tumors.

Biomolecules 2020 Jun 25;10(6). Epub 2020 Jun 25.

School of Medicine, Department of Radiation Oncology, University of Minnesota, Minneapolis, MN 55455 USA.

Ligand-targeted toxins (LTTs) are bioengineered molecules which are composed of a targeting component linked to a toxin that induces cell death once the LTT binds its target. Bispecific targeting allows for the simultaneous targeting of two receptors. In this review, we mostly focus on the epidermal growth factor receptor (EGFR) as a target. Read More

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http://dx.doi.org/10.3390/biom10060956DOI Listing

Intravascular Cutaneous Disorders. A Clinicopathologic Review.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Intravascular proliferations of the skin are clinically heterogeneous and may present with a wide range of clinical features, including violaceous papules, nodules, plaques, or other unspecific cutaneous lesions. Histopathologically, these conditions are characterized by proliferation of different cell types within the lumina of dermal vessels and endothelial cell hyperplasia. Immunohistochemistry is the best tool to identify the nature of the intravascular proliferating cells and the type of involved vessel. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001706DOI Listing

Radiotherapy for Adult Soft Tissue Sarcomas of the Head and Neck.

Am J Clin Oncol 2020 Jun 30. Epub 2020 Jun 30.

Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL.

Objective: Surgery followed by postoperative radiation therapy (RT) is the standard of care for soft tissue sarcomas (STS) of the head and neck that are high grade or have close or positive margins.

Methods: The authors retrospectively reviewed adult patients with head and neck STS treated with RT at a single institution between 1981 and 2017. All patients who were 19 years and older with STS of the head and neck-excluding rhabdomyosarcoma, angiosarcoma, and Ewing tumors-were included in this study. Read More

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http://dx.doi.org/10.1097/COC.0000000000000729DOI Listing

Angiosarcoma of bone: a retrospective study of the European Musculoskeletal Oncology Society (EMSOS).

Sci Rep 2020 Jul 2;10(1):10853. Epub 2020 Jul 2.

IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Angiosarcoma of bone (B-AS) is a rare malignant tumor of vascular origin. The aim of this retrospective study is to report on treatments and prognosis. Data were collected from the EMSOS website. Read More

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http://dx.doi.org/10.1038/s41598-020-66579-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331738PMC

Radiation-induced angiosarcoma in a patient with breast cancer.

Lancet Oncol 2020 07;21(7):e369

Department of Surgical Oncology, Geisinger Medical Center, Danville, PA, USA.

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http://dx.doi.org/10.1016/S1470-2045(20)30212-6DOI Listing

Antiprogrammed cell death protein 1 immunotherapy for angiosarcoma with high programmed death-ligand 1 expression: a case report.

Immunotherapy 2020 Jul 2. Epub 2020 Jul 2.

Department of Respiratory Diseases, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, China.

Angiosarcoma (AS) is a rare malignancy originating from lymphatic or vascular endothelial cells. Prognosis of the disease is usually dismal and there is no effective treatment. Immunotherapy has been proved to be effective for various cancer types. Read More

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http://dx.doi.org/10.2217/imt-2020-0122DOI Listing

Bone up on spinal osseous lesions: a case review series.

Insights Imaging 2020 Jun 29;11(1):80. Epub 2020 Jun 29.

Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Spinal osseous neoplasms are frequently encountered and can be challenging when present as solitary lesions. Familiarity with the range of benign and malignant spinal pathology can help the radiologist formulate a comprehensive differential diagnosis. This article focuses on the spectrum of extradural spinal tumors, accounting for the majority of primary spinal tumors, by comparing the epidemiology, pathophysiology, clinical presentation, and characteristic imaging appearance of these lesions. Read More

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http://dx.doi.org/10.1186/s13244-020-00883-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324468PMC

Comparison of the clinical and MRI features of patients with hepatic hemangioma, epithelioid hemangioendothelioma, or angiosarcoma.

BMC Med Imaging 2020 Jun 29;20(1):71. Epub 2020 Jun 29.

Department of Radiology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University, No. 23 Haibang Street, Jiangmen, 529000, Guangdong, China.

Background: Comparisons of hepatic epithelioid hemangioendothelioma (HEHE), hepatic hemangioma, and hepatic angiosarcoma (HAS) have rarely been reported. The purpose of our study was to analyze the clinical and magnetic resonance imaging (MRI) findings of these conditions.

Methods: A total of 57 patients (25 with hemangioma, 13 with HEHE, and 19 with HAS) provided hepatic vascular endothelial cell data between June 2006 and May 2017. Read More

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http://dx.doi.org/10.1186/s12880-020-00465-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322860PMC

Anastomosing Hemangioma of the Breast: An Unusual Case at an Unusual Site.

J Breast Cancer 2020 Jun 17;23(3):326-330. Epub 2020 Feb 17.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, Texas, USA.

Anastomosing hemangioma (AH) is an unusual benign vascular lesion that commonly occurs in the kidney and genitourinary tract. We report a case of AH in a 49-year-old woman presenting as a mass in the breast, a site which, to the best of our knowledge, has not been previously documented in the English literature. Microscopic examination of the mass revealed a well-demarcated proliferation of anastomosing vascular spaces lined by bland endothelial cells, with focal hobnailing and scattered intravascular fibrin thrombi. Read More

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http://dx.doi.org/10.4048/jbc.2020.23.e15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311365PMC

The β-adrenergic receptor antagonist propranolol offsets resistance mechanisms to chemotherapeutics in diverse sarcoma subtypes: a pilot study.

Sci Rep 2020 Jun 26;10(1):10465. Epub 2020 Jun 26.

Experimental Pharmacology Laboratory, IRCCS Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124, Bari, Italy.

Standard chemotherapy for soft tissue sarcomas has shown limited efficacy. Here, we sought to evaluate whether β-adrenergic receptor (β-AR) signalling contributed to the progression of sarcomas and therapy resistance. To assess the translational potential of β-adrenergic receptors, we performed immunohistochemical detection of β1-AR, β2-AR and β3-AR in leiomyosarcoma, liposarcoma and angiosarcoma tissue specimens, reporting the results scored for the intensity. Read More

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http://dx.doi.org/10.1038/s41598-020-67342-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320177PMC

Giant primary angiosarcoma of an adolescent girl's breast diagnosed postmortem: a case report.

J Med Case Rep 2020 Jun 27;14(1):80. Epub 2020 Jun 27.

Department of Pathology, University Teaching Hospital of Lomé, Lomé, BP 1515, Togo.

Background: Angiosarcoma is an endothelial malignant tumor; angiosarcoma located in the breast is extremely rare, less than 0.01%. We report a case of a giant angiosarcoma diagnosed postmortem in a 16-year-old girl in a resource-constrained country. Read More

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http://dx.doi.org/10.1186/s13256-020-02403-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320594PMC

Reirradiation for Recurrent Scalp Angiosarcoma: Dosimetric Advantage of PBT over VMAT and EBT.

Int J Part Ther 2020 16;6(3):13-18. Epub 2019 Dec 16.

Department of Radiation Oncology, University Hospitals Seidman Cancer Center at Case Western Reserve University, Cleveland, OH, USA.

Purpose: Reirradiation in the scalp area can be challenging given the proximity to organs at risk (OARs), such as the eye and brain. Our aim is to evaluate the dosimetric differences of volumetric modulated arc therapy (VMAT) and electron beam therapy (EBT) compared with 3-dimensional proton beam therapy (PBT).

Patients And Methods: We evaluated a patient with recurrent angiosarcoma of the left temporal scalp after prior surgical resections and radiation therapy to 60 Gy in 30 fractions who needed reirradiation. Read More

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http://dx.doi.org/10.14338/IJPT-19-00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038915PMC
December 2019

Primary pericardial angiosarcoma: case report and review of treatment options.

Ecancermedicalscience 2020 15;14:1056. Epub 2020 Jun 15.

Department of Hematology and Oncology, Case Western University School of Medicine, Cleveland, OH, USA.

A primary cardiac angiosarcoma is a rare type of soft-tissue sarcoma with a high mortality rate. This report describes a young woman who presented with chest pain and worsening shortness of breath over the course of a year. She was diagnosed with and treated for latent tuberculosis and autoimmune pericarditis over the last year, however, her condition kept worsening. Read More

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http://dx.doi.org/10.3332/ecancer.2020.1056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302885PMC

A rare case of multimetastatic cardiac angiosarcoma.

Radiol Case Rep 2020 Aug 18;15(8):1271-1274. Epub 2020 Jun 18.

Department of Pathology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Cardiac malignant tumors are rare entities with nonspecific clinical presentation and poor prognosis. Here, we report a case of about a 30-year-old man who was admitted for right thoracic pain. Imaging indicated a cardiac malignant tumor, and pathology confirmed the diagnosis. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305366PMC

Chromatin run-on sequencing analysis finds that ECM remodeling plays an important role in canine hemangiosarcoma pathogenesis.

BMC Vet Res 2020 Jun 22;16(1):206. Epub 2020 Jun 22.

Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

Background: Canine visceral hemangiosarcoma (HSA) is a highly aggressive cancer of endothelial origin that closely resembles visceral angiosarcoma in humans, both clinically and histopathologically. Currently there is an unmet need for new diagnostics and therapies for both forms of this disease. The goal of this study was to utilize Chromatin run-on sequencing (ChRO-seq) and immunohistochemistry (IHC) to identify gene and protein expression signatures that may be important drivers of HSA progression. Read More

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http://dx.doi.org/10.1186/s12917-020-02395-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310061PMC

Primary Ewing sarcoma of the lung: a challenging case.

J R Coll Physicians Edinb 2020 Jun;50(2):141-143

Department of Respiratory Medicine, Royal Lancaster Infirmary, University Hospitals of Morecambe Bay NHS Foundation Trust.

Ewing sarcoma usually develops in the second decade of life as a primary osseous malignancy. An extraskeletal primary source of this condition from the lung parenchyma is extremely uncommon. We report the case of a 33-year old man with primary Ewing sarcoma of the lung diagnosed upon postsurgical histological examination. Read More

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http://dx.doi.org/10.4997/JRCPE.2020.212DOI Listing

Outcomes of 43 small breed dogs treated for splenic hemangiosarcoma.

Vet Surg 2020 Jun 20. Epub 2020 Jun 20.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.

Objective: To determine outcome and prognostic factors in small breed dogs in which hemangiosarcoma was diagnosed and whether outcomes differed between small and large breed dogs with splenic hemangiosarcoma.

Study Design: Bi-institutional retrospective study.

Animals: Forty-three small breed (<20 kg) and 94 large breed client-owned dogs. Read More

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http://dx.doi.org/10.1111/vsu.13470DOI Listing

Prominent Bone Marrow Metastases Without Concurrent Intra-Chest Metastasis in a Case of Cardiac Angiosarcoma.

Clin Nucl Med 2020 Aug;45(8):638-639

From the Department of Nuclear Medicine, West China Hospital; Sichuan University, Chengdu, Sichuan, People's Republic of China.

Primary cardiac angiosarcoma is rare and often advances by dissemination. Lungs are the most common metastatic sites, especially when the tumor originates in the right side of the heart. Bone metastases from cardiac angiosarcoma very rarely occur without concurrent pulmonary metastases. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003130DOI Listing

Secondary Angiosarcoma With C-MYC Amplification Following Prophylactic Bilateral Mastectomy and Autologous Breast Reconstruction: Report of a Case and Review of the Literature.

Int J Surg Pathol 2020 Jun 18:1066896920930100. Epub 2020 Jun 18.

UT Southwestern Medical Center, Dallas, TX, USA.

In this article, we report a very rare case of secondary angiosarcoma in a young woman with no prior history of breast cancer who had bilateral prophylactic mastectomies with autologous reconstruction due to a strong family history of breast cancer and gene variant of uncertain significance. The surgery was complicated by recurrent fat necrosis requiring several excisions and additional reconstruction followed by the development of localized lymphedema and subsequent angiosarcoma in the reconstructed breast 10 years later. The angiosarcoma was high grade with prominent epithelioid features associated with abundant tumor-infiltrating lymphocytes. Read More

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http://dx.doi.org/10.1177/1066896920930100DOI Listing

Duodenal metastases of an angiosarcoma of the thyroid gland.

Clin Gastroenterol Hepatol 2020 Jun 13. Epub 2020 Jun 13.

Department of Gastroenterology, University Hospital Augsburg, Germany.

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http://dx.doi.org/10.1016/j.cgh.2020.06.009DOI Listing

Benefits of the Multidisciplinary Approach After Curative Surgery for the Treatment of Scalp Angiosarcoma.

Ann Plast Surg 2020 Jun 11. Epub 2020 Jun 11.

From the Department of Plastic Surgery.

Background: Patients with scalp angiosarcoma still present with a dismal prognosis, indicating the need for a multidisciplinary approach. The present study aimed to investigate the treatment outcomes of scalp angiosarcoma with a focus on the effect of radiotherapy and chemotherapy, performed in either an adjuvant or palliative setting, after curative surgical treatment.

Methods: Patients with scalp angiosarcoma without evidence of systemic metastasis who were treated with curative ablative surgery between 2008 and 2018 were assessed. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002462DOI Listing

Immunotherapy in sarcoma: combinations or single agents? In whom?

Curr Opin Oncol 2020 Jul;32(4):339-343

Medical Oncology Department, Centre Leon Berard, Lyon, France.

Purpose Of Review: First clinical trials investigating immune check point (ICP) inhibitors in patients with sarcoma, regardless histological or molecular subtypes did not demonstrate any prolonged benefit. To maximize the chance of benefit from immunotherapy, recent strategies explore the combination of treatments and aim to improve identification of responsive histological subtypes.

Recent Findings: Combination of several ICP inhibitors tends to increase toxicity and efficacy. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000651DOI Listing

Angiosarcoma on the scalp and face associated with Kasabach-Merritt phenomenon.

Eur J Dermatol 2020 Jun 14. Epub 2020 Jun 14.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1684/ejd.2020.3788DOI Listing

A Genomic Survey of Sarcomas on Sun-Exposed Skin Reveals Distinctive Candidate Drivers and Potentially Targetable Mutations.

Hum Pathol 2020 Jun 12. Epub 2020 Jun 12.

Department of Pathology, University of Michigan, 2800 Plymouth Rd, Ann Arbor, MI, 48109, USA; Department of Dermatology, University of Michigan, 1500 E. Medical Center Drive Ann Arbor, MI, 48109, USA; Rogel Cancer Center, University of Michigan, 1500 E. Medical Center Drive Ann Arbor, MI, 48109, USA. Electronic address:

Sarcomas on photodamaged skin vary in prognosis and management, but can display overlapping microscopic and immunophenotypic features. Improved understanding of molecular alterations in these tumors may provide diagnostic and therapeutic insights. We characterized 111 cutaneous sarcomatoid malignancies and their counterparts, including primary cutaneous angiosarcoma (n=7), atypical fibroxanthoma (AFX)(n=21), pleomorphic dermal sarcoma (PDS)(n=17), extracutaneous undifferentiated pleomorphic sarcoma (n=8), cutaneous leiomyosarcoma (LMS)(n=5), extracutaneous leiomyosarcoma (n=9), sarcomatoid squamous cell carcinoma (spindle cell squamous cell carcinoma)(S-SCC)(n=24), and conventional cutaneous squamous cell carcinoma (SCC)(n=20) by next generation sequencing (NGS) using the StrataNGS panel for copy number variations (CNVs), mutations, and/or fusions in over 60 cancer-related genes. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.06.003DOI Listing

Hepatic epithelioid hemangioendothelioma: An international multicenter study.

Dig Liver Dis 2020 Jun 10. Epub 2020 Jun 10.

BCLC group. Liver Unit. Hospital Clinic de Barcelona. IDIBAPS. CIBERehd. University of Barcelona, Barcelona, Spain. Electronic address:

Background And Aims: Hepatic epithelioid hemangioendothelioma is an ultra-rare hepatic vascular tumor, diagnosed more frequently in females. The knowledge about this tumor derives mainly from small case series with sub-optimal treatment outcomes. The aim of this study is to identify the clinical and radiological issues helpful to develop an international prospective registry. Read More

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http://dx.doi.org/10.1016/j.dld.2020.05.003DOI Listing

TP53-Deficient Angiosarcoma Expression Profiling in Rat Model.

Cancers (Basel) 2020 Jun 10;12(6). Epub 2020 Jun 10.

Department of Experimental Pharmacology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland.

Sarcomas are a heterogeneous group of malignant tumors, that develop from mesenchymal cells. Sarcomas are tumors associated with poor prognosis and expected short overall survival. Efforts to improve treatment efficacy and treatment outcomes of advanced and metastatic sarcoma patients have not led to significant improvements in the last decades. Read More

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http://dx.doi.org/10.3390/cancers12061525DOI Listing

Gingival Angiosarcoma: A Case Report and Clinicopathologic Review of 32 Cases of Primary Gingival Angiosarcoma.

Indian J Surg Oncol 2020 Jun 14;11(2):235-240. Epub 2020 Jan 14.

Department of Laboratory Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India.

Angiosarcoma is a malignant neoplasm of mesenchymal origin arising from vascular endothelium and most commonly involves extremities. Gingival angiosarcoma is a rare sporadic occurring tumor. We report a case of primary angiosarcoma of gingiva along with a review of 31 cases of primary gingival angiosarcoma reported in literature till 2018. Read More

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http://dx.doi.org/10.1007/s13193-020-01032-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260341PMC

Serum anti-p53 autoantibodies in angiosarcoma.

J Dermatol 2020 Jun 8. Epub 2020 Jun 8.

Departments of, Department of, Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

There is no biomarker for detecting the status of angiosarcoma patients. Studies have reported that serum anti-p53 antibody (Ab) levels are often high in patients with various types of malignant tumors, suggesting the potential use of this Ab as a biomarker for various tumors, including angiosarcoma. The aim of this study was to assess the usefulness of serum anti-p53 Ab as a potent angiosarcoma biomarker. Read More

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http://dx.doi.org/10.1111/1346-8138.15416DOI Listing

RANK-RANKL signalling pathway contributes to disease progression in cutaneous angiosarcoma: a case report with an immunohistochemical review and in vitro experiments.

J Eur Acad Dermatol Venereol 2020 Jun 8. Epub 2020 Jun 8.

Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1111/jdv.16714DOI Listing

Colonic Angiosarcoma Arising in Association with Amyloid Deposits.

Case Rep Gastrointest Med 2020 16;2020:3780763. Epub 2020 May 16.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Angiosarcoma of the colon is rare, as is colonic amyloidosis. To our knowledge, there have been no reported cases of angiosarcoma arising in association with amyloid deposition. Herein, we described a case of 77-year-old man who presented with hematochezia, and a sigmoid mass was found on colonoscopy. Read More

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http://dx.doi.org/10.1155/2020/3780763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246417PMC

IL-23 Expression in Stewart-Treves Syndrome: Two Case Reports and Immunohistochemical Investigation.

Case Rep Oncol 2020 Jan-Apr;13(1):462-467. Epub 2020 Apr 30.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Stewart-Treves syndrome (STS) is a rare cutaneous lymphangiosarcoma developing from chronic lymph edema as a consequence of radical mastectomy or surgical invasion of the groin for the treatment of cervical or penile cancer. Previous reports suggested possible mechanisms in the development of lymphangiosarcoma that correlate with the immunological background of STS patients. In this report, we described two cases of STS developing in patients who underwent radical dissection for cervical cancer, we employed immunohistochemical staining of IL-23 and IL-17. Read More

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http://dx.doi.org/10.1159/000506975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250377PMC

MYC Expression has Limited Utility in the Distinction of Undifferentiated Radiation-associated Sarcomas from Sporadic Sarcomas and Sarcomatoid Carcinoma.

Histopathology 2020 Jun 7. Epub 2020 Jun 7.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.

Aim: MYC is a proto-oncogene frequently dysregulated in various malignancies through translocation or amplification. Radiation-associated angiosarcoma frequently shows MYC amplification and immunohistochemistry has been shown to be a reliable surrogate marker for amplification, but less is known about MYC expression in other sarcoma types despite reported MYC amplification in some undifferentiated/unclassified radiation-associated sarcomas (RAS). Distinguishing putative RAS from non-radiation-associated sarcoma or sarcomatoid carcinoma can be difficult. Read More

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http://dx.doi.org/10.1111/his.14168DOI Listing

Giant pericardial-occupying compressive primary cardiac hemangiosarcoma in a cat.

J Vet Cardiol 2020 Jun 5;29:54-59. Epub 2020 May 5.

The Animal Medical Center, 510 East 62nd Street, New York, NY 10065, USA. Electronic address:

Hemangioarcoma in the cat is an infrequently diagnosed tumor, and cardiac involvement is rare. We report a previously healthy, 8-year-old, domestic shorthair cat with acute collapse associated with pericardial effusion and cardiac tamponade. Following pericardiocentesis and removal of 15 mL of fluid, the cat improved rapidly. Read More

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http://dx.doi.org/10.1016/j.jvc.2020.04.004DOI Listing

Imaging features of pathologically proven pediatric splenic masses.

Pediatr Radiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, 02115, USA.

Splenic masses present a diagnostic challenge to radiologists and clinicians alike, with a relative paucity of data correlating radiologic findings to pathological diagnosis in the pediatric population. To illustrate splenic mass imaging findings and approximate lesion prevalence, we retrospectively reviewed all splenectomies and splenic biopsies for splenic masses at a single academic pediatric hospital over a 10-year period in patients 18 years and younger. A total of 31 splenic masses were analyzed. Read More

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http://dx.doi.org/10.1007/s00247-020-04692-3DOI Listing

Genetic aberrations and molecular biology of cardiac sarcoma.

Ther Adv Med Oncol 2020 18;12:1758835920918492. Epub 2020 May 18.

Department of Specialized, Experimental and Diagnostic Medicine, Medical Oncology Unit, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, Bologna, Bologna 40138, Italy.

Cardiac tumors are rare and complex entities. Early assessment and differentiation between non-neoplastic and neoplastic masses, be they benign or malignant, is essential for guiding diagnosis, determining prognosis, and planning therapy. Cardiac sarcomas represent the most frequent primary malignant histotype. Read More

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http://dx.doi.org/10.1177/1758835920918492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238448PMC

Features of rare primary cardiac angiosarcoma in multimodality imaging.

Jpn J Clin Oncol 2020 Jun 2. Epub 2020 Jun 2.

Department of Cardiovascular Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1093/jjco/hyaa074DOI Listing
June 2020
1.747 Impact Factor

"The unusual suspects"-Mammographic, sonographic, and histopathologic appearance of atypical breast masses.

Clin Imaging 2020 May 3;66:111-120. Epub 2020 May 3.

Department of Radiology, St Louis University School of Medicine, United States of America. Electronic address:

Breast malignancy is the second most common cause of cancer death in women. However, less common breast masses can mimic carcinoma and can pose diagnostic challenges. This case-based review describes a spectrum of rare breast neoplastic and non-neoplastic masses ranging from malignant to benign entities. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.04.039DOI Listing
May 2020
0.596 Impact Factor

Combined nab-paclitaxel and irradiation for large cutaneous angiosarcoma of the face and scalp with pulmonary metastases.

J Dtsch Dermatol Ges 2020 May 29. Epub 2020 May 29.

Department of Dermatology, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1111/ddg.14127DOI Listing

Large primary cutaneous angiosarcoma of the nose successfully treated surgically.

Postepy Dermatol Alergol 2020 Feb 9;37(1):121-124. Epub 2020 Mar 9.

Clinic of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Faculty of Medicine in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

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http://dx.doi.org/10.5114/ada.2019.82638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247061PMC
February 2020

Report of two rare cases of adrenal incidentalomas with different origins: revisiting pathological and radiological findings with a short review of the literature.

J Egypt Natl Canc Inst 2020 May 27;32(1):25. Epub 2020 May 27.

Urology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

Background: Adrenal tumors can be detected incidentally in 4 to 8% of patients radiologically. Adenomas, pheochromocytomas, and adrenocortical carcinomas represent the most common tumors of the adrenal glands. Rare histopathological findings are uncommon. Read More

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http://dx.doi.org/10.1186/s43046-020-00039-zDOI Listing

Regional Lymph Node Metastasis of Scalp Angiosarcoma: A Detailed Clinical Observation Study of 40 Cases.

Ann Surg Oncol 2020 Aug 26;27(8):3018-3027. Epub 2020 May 26.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: The incidence of lymph node metastasis (LNM) of angiosarcomas is reported to be less than 15%, and elective neck management has not been indicated. This study evaluated the incidence and pattern of regional LNM in patients with scalp angiosarcomas using the clinical data of its full course to understand time-event sequences of scalp angiosarcomas.

Methods: This retrospective study included all consecutive cases of pathology-confirmed angiosarcomas and analyzed 40 cases of scalp angiosarcomas. Read More

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http://dx.doi.org/10.1245/s10434-020-08408-7DOI Listing

Complete Resection of Cardiac Angiosarcoma Invading Right Heart and Right Coronary Artery.

Ann Thorac Surg 2020 May 23. Epub 2020 May 23.

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Complete surgical resection is the most critical factor to achieve better long-term outcomes in treating primary cardiac sarcomas, however, it is oftentimes hampered when there is extensive tumor involvement into important cardiac apparatus. Here, we report a case of successful complete resection of a cardiac sarcoma infiltrating the right atrio-ventricle, tricuspid valve and right coronary artery. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.04.026DOI Listing

Norepinephrine release may play a critical role in the Warburg effect: an integrative model of tumorigenesis.

Neoplasma 2020 May 26. Epub 2020 May 26.

Department of Psychiatry, University of Michigan, Ann Arbor, United States.

Many cancer cells share the property of carrying out markedly elevated rates of glycolysis to generate energy even in the presence of sufficient oxygen, and this is known as the Warburg effect. In recent years, there has been a resurgence of interest in the Warburg effect, as the field of oncology has amassed evidence that cellular metabolism may play a prominent role in many neoplasms. Largely in the past decade, another prominent and perhaps surprising factor has emerged in the cancer literature: the catecholamine molecules, epinephrine (adrenaline) and norepinephrine (noradrenaline), appear to play a role in tumorigenesis and metastasis. Read More

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http://dx.doi.org/10.4149/neo_2020_200422N432DOI Listing

Prognostic significance of positive surgical margins for scalp angiosarcoma.

J Formos Med Assoc 2020 May 20. Epub 2020 May 20.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. Electronic address:

Background: Scalp angiosarcomas (AS) are aggressive soft tissue sarcomas that present with outcomes different from other AS of the head and neck region. Due to the rarity of the disease, limited data on the clinical outcome of scalp AS are available. In particular, the prognostic significance of surgical margins remains controversial and the impact of margin status on survival has not been documented. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.04.018DOI Listing