9,599 results match your criteria Angiosarcoma


Posterior Mediastinal Epithelioid Angiosarcoma Arising in Schwannoma: A Case Report and Review of the Literature.

Front Surg 2021 28;8:666389. Epub 2021 May 28.

Lishui Municipal Central Hospital, Lishui, China.

Epithelioid angiosarcoma arising in schwannoma is an extremely rare mesenchymal tumor that accounts for only 1 to 2% of all sarcomas. This type of tumor occurs in all parts of the body, most often in the skin and soft tissues and rarely in the mediastinum. The present study describes the case of an asymptomatic, 58-year-old male who presented with epithelioid angiosarcoma in the posterior mediastinum during a physical examination. Read More

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Successful perioperative management of a primary pulmonary arterial angiosarcoma - Case report.

Braz J Anesthesiol 2021 Jun 9. Epub 2021 Jun 9.

Hospital Universitari Son Espases, Cardiovascular Surgery, Quiron Clinica Rotger and Head of Service, Lead Consultant Cardiac Surgeon, Palma de Mallorca, Spain.

Introduction: Primary pleomorphic pulmonary angiosarcomas are extremely rare tumors which could be easily mistaken for pulmonary emboli.

Background And Findings: We describe the successful perioperative management of a patient with a pulmonary arterial mass which turned out to be a primary pulmonary angiosarcoma. The severe pulmonary hypertension was a particular challenge compounded with the site and adhesions of the tumor, and pulmonary hemorrhage. Read More

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Aortic Angiosarcoma in Association with Endovascular Aneurysm Repair: Case Report and Review of the Literature.

Am J Case Rep 2021 Jun 12;22:e931740. Epub 2021 Jun 12.

Division of Clinical Pathology, Niigata University Faculty of Medicine, Niigata, Japan.

BACKGROUND Primary aortic sarcoma often poses diagnostic challenges for pathologists and clinicians because of a very low incidence and controversy over nomenclature and definition. We report a case of aortic angiosarcoma in association with a graft. We also conducted a clinicopathological review of cases of primary aortic sarcomas associated with implanted grafts. Read More

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The role of radiation therapy in the management of cutaneous malignancies. Part II: When is radiation therapy indicated?

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Departments of Dermatology and Head and Neck Surgery, The University of Texas MD Anderson Cancer, Houston, Texas, USA.

Radiation therapy may be performed for a variety of cutaneous malignancies depending on patient health status, tumor clinical and histologic features, patient preference, and resource availability. Dermatologists should be able to recognize the clinical scenarios in which radiation therapy is appropriate as this may reduce morbidity, decrease risk of disease recurrence, and improve quality of life. The second article in this 2-part continuing medical education series focuses on the most common indications for radiation therapy in the treatment of basal cell carcinoma, cutaneous squamous cell carcinoma, dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi sarcoma, angiosarcoma, cutaneous lymphoma, melanoma, undifferentiated pleomorphic sarcoma, and sebaceous carcinoma. Read More

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[An autopsy case of hepatic angiosarcoma diagnosed with ultrasonography-guided percutaneous needle biopsy of the liver].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(6):562-570

Department of Gastroenterological Medicine, South-nara General Medical Center.

Contrast medium-enhanced computed tomography revealed a mass in the liver of a 65-year-old man. The edge but not the center of the mass was enhanced. Ultrasonography-guided percutaneous needle biopsy revealed the diagnosis of angiosarcoma of the liver, and it was treated with chemotherapy. Read More

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Unusual presentation of metastatic radiogenic breast angiosarcoma.

Jpn J Clin Oncol 2021 Jun 9. Epub 2021 Jun 9.

Peritoneal Tumours Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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Current Management of Angiosarcoma: Recent Advances and Lessons From the Past.

Curr Treat Options Oncol 2021 Jun 7;22(7):61. Epub 2021 Jun 7.

Department of Medicine, Division of Medical Oncology, University of Colorado School of Medicine, 1665 Aurora Court Anschutz Cancer Pavilion, Aurora, CO, USA.

Opinion Statement: Despite their rarity, angiosarcomas are one of the most aggressive soft tissue sarcomas. Management can often be challenging due to their location and infiltrative nature. A multidisciplinary treatment approach is always warranted, but the recurrence remains high even for localized tumors despite multimodality treatment. Read More

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Epithelioid Haemangioma of Bone: A Case Series and Comprehensive Literature Review Reappraising the Diagnostic Classification of All Epithelioid Vascular Neoplasms of Bone.

Cureus 2021 Jun 1;13(6):e15371. Epub 2021 Jun 1.

Pathology, Woodland Hospital, Shillong, IND.

Epithelioid vascular neoplasms of the bone are classified by the World Health Organization (WHO) into only two tiers: low-grade epithelioid hemangioma (EH) and a more malignant category including both epithelioid hemangioendothelioma and epithelioid angiosarcoma. The World Health Organization defines bone EH as a locally aggressive neoplasm with no connotation of benign or intermediate malignancy. We reviewed three cases of EH in our lab archives with the perspective of appraising their histomorphological approach toward diagnosis. Read More

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Cutaneous symplastic hemangioma: a series of four cases.

J Cutan Pathol 2021 Jun 5. Epub 2021 Jun 5.

From the Department of Pathology, Cleveland Clinic, Cleveland, OH.

Symplastic hemangiomas are benign vascular lesions that demonstrate atypia in vascular smooth muscle and interstitial cells with sparing of endothelial cells. We present four cases of this rare tumor. The patients (2M;2F) ranged in age from 57-83 years (median 74); lesions were located on the leg (n=3) and back (n=1), and ranged from 6-8 mm. Read More

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Photodynamic therapy of classic Kaposi's sarcoma with video-fluorescence control.

Photodiagnosis Photodyn Ther 2021 Jun 1;35:102378. Epub 2021 Jun 1.

Department of Laser Micro-, Nano-, and Biotechnology, Institute of Engineering Physics for Biomedicine, National Research Nuclear University "MEPhI", Kashirskoe sh., 31, Moscow 115409, Russian Federation; Prokhorov General Physics Institute of the Russian Academy of Sciences, ul. Vavilova 38, Moscow 119991, Russian Federation.

Background: Kaposi's sarcoma (multiple idiopathic hemorrhagic sarcoma, Kaposi's angiosarcoma) is an angioproliferative neoplasm of endothelial origin associated with human herpes virus 8 (HHV - 8) and human immunodeficiency virus (HIV). The incidence of the classical form of Kaposi's sarcoma (КS) varies significantly in different geographical areas from 0.14/1 million people (both men and women) to 10. Read More

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Rare Mimic of Angiosarcoma: Erythema Ab Igne with Reactive Angiomatosis.

J Cutan Pathol 2021 Jun 4. Epub 2021 Jun 4.

Section of Dermatology, Department of Internal Medicine Department of Basic Science Education, Virginia Tech Carilion School of Medicine and Carilion Clinic.

Erythema ab igne is an uncommon physical dermatosis that presents with localized patches of reticulated erythema and hyperpigmentation corresponding with the underlying dermal venous plexus. The rash occurs in response to chronic heat exposure that does not meet the threshold for thermal burn of the skin. The histopathologic findings are characterized by atrophy and thinning of the epidermis, focal hyperkeratosis, and keratinocyte atypia. Read More

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PARP inhibition in UV-associated angiosarcoma preclinical models.

J Cancer Res Clin Oncol 2021 Jun 3. Epub 2021 Jun 3.

Department of Medical Oncology, Radboud University Medical Center, Internal Postal Code 452, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Purpose: Angiosarcoma (AS) is a rare vasoformative sarcoma, with poor overall survival and a high need for novel treatment options. Clinically, AS consists of different subtypes, including AS related to previous UV exposure (UV AS) which could indicate susceptibility to DNA damage repair inhibition. We, therefore, investigated the presence of biomarkers PARP1 (poly(ADP-ribose)polymerase-1) and Schlafen-11 (SLFN11) in UV AS. Read More

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Living donor liver transplantation for hepatic malignancies in children.

Pediatr Transplant 2021 Jun 2:e14047. Epub 2021 Jun 2.

Pediatric and Transplantation Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Background: Living donor liver transplantation is a treatment option for unresectable hepatic tumors in children.

Methods: We enrolled 45 living donor transplantations performed between 1993 and 2018 for liver malignacies, which included hepatoblastoma (n = 33), hepatocellular carcinoma (n = 10), hepatic angiosarcoma (n = 1), and rhabdomyosarcoma (n = 1).

Results: No mortality or major morbidities were encountered in any donor, and the complication rate was 9%. Read More

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Plasma Metabolomics Analysis of Polyvinyl Chloride Workers Identifies Altered Processes and Candidate Biomarkers for Hepatic Hemangiosarcoma and Its Development.

Int J Mol Sci 2021 May 11;22(10). Epub 2021 May 11.

Department of Medicine, University of Louisville, Louisville, KY 40202, USA.

Background: High-level occupational vinyl chloride (VC) exposures have been associated with hepatic hemangiosarcoma, which typically develops following a long latency period. Although VC is genotoxic, a more comprehensive mode of action has not been determined and diagnostic biomarkers have not been established. The purpose of this study is to address these knowledge gaps through plasma metabolomics. Read More

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CT Findings of Pulmonary Metastases from Primary Cardiac Angiosarcoma.

Curr Med Imaging 2021 May 21. Epub 2021 May 21.

Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Background: Primary cardiac angiosarcoma is a rare malignancy with high predilection to involve surrounding structures such as pulmonary metastases. We analysed the chest computed tomography (CT) imaging features of patients diagnosed with primary cardiac angiosarcoma with pulmonary metastases in this study.

Methods: This study retrospectively reviewed 12 patients with confirmed primary cardiac angiosarcoma, out of which eight (all men) with pulmonary metastasis were included in the analysis. Read More

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Tertiary lymphoid structures correlate with better prognosis in cutaneous angiosarcoma.

J Dermatol Sci 2021 May 25. Epub 2021 May 25.

Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Japan.

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Intravascular histiocytosis: mimicker of cellulitis, angiosarcoma, inflammatory breast cancer, and others.

Int J Dermatol 2021 May 31. Epub 2021 May 31.

Mayo Clinic, Rochester, MN, USA.

Background: Intravascular histiocytosis is an underrecognized reactive skin condition characterized by the clinical finding of poorly demarcated erythematous to violaceous patches and plaques. The diagnosis is confirmed by the histologic findings of intraluminal histiocytes on skin biopsy and exclusion of an alternative diagnosis.

Methods: A review of patients with a histologic diagnosis of intravascular or intralymphatic histiocytosis and seen at Mayo Clinic, Rochester, Minnesota, from January 1, 2010, to October 10, 2020, was performed. Read More

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Prognostic implications of PD-L1 expression in patients with angiosarcoma.

Future Sci OA 2021 Mar 2;7(5):FSO691. Epub 2021 Mar 2.

Department of Internal Medicine, Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

Aim: There are limited data on the feasibility of programmed death ligand-1 (PD-L1) expression as a prognostic biomarker in metastatic angiosarcoma.

Patients & Methods: We retrospectively collected and analyzed the data on PD-L1 expression in 70 angiosarcoma patients who were diagnosed at our center between 2005 and 2019.

Results: Thirteen (19%) patients had PD-L1 expression. Read More

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Ovarian epithelioid angiosarcoma complicating pregnancy: a case report and review of the literature.

J Int Med Res 2021 May;49(5):3000605211019641

Department of Gynecology and Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.

Epithelioid angiosarcoma is a rare and highly aggressive soft tissue angiosarcoma most commonly arising in the deep soft tissues. Given that abundant vascular cavities anastomose with each other, most angiosarcomas prone to metastasis recur quickly, and the overall prognosis is poor. We report a 25-year-old woman at 24 weeks' gestation who presented with a 1-month history of abdominal distension. Read More

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Metastatic Cutaneous Angiosarcoma: A Rare Entity.

Cureus 2021 Apr 20;13(4):e14577. Epub 2021 Apr 20.

Pulmonary Medicine, Saint Peter's University Hospital, New Brunswick, USA.

We present a case of a 56-year-old female presented with a chief complaint of four months of dyspnea that had acutely worsened. The patient also reported a chronic right thigh wound. Chest radiograph on initial presentation demonstrated multiple bilateral rounded opacities. Read More

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[Successful surgical resection of primary cardiac angiosarcoma: a case report].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 May;49(5):513-515

Cardiac Surgery Ⅲ, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

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Diffuse Cutaneous Angiosarcoma in the Scalp and Face Demonstrated on FDG PET/CT Imaging.

Clin Nucl Med 2021 May 26. Epub 2021 May 26.

From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Abstract: Diffuse cutaneous angiosarcomas are rare. Herein, we reported FDG PET/CT findings of cutaneous angiosarcoma in a 59-year-old man. FDG PET/CT imaging was performed for staging, showing diffuse intense FDG uptake with an SUVmax of 19 in the scalp and face. Read More

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Zebrafish Tumor Graft Transplantation to Grow Tumors That Engraft Poorly as Single Cell Suspensions.

Zebrafish 2021 May 24. Epub 2021 May 24.

Department of Molecular Medicine, Greehey Children's Cancer Research Institute (GCCRI), UT Health Sciences Center, San Antonio, Texas, USA.

Angiosarcoma is a clinically aggressive tumor with a high rate of mortality. It can arise in vascular or lymphatic tissues, involve any part of the body, and aggressively spread locally or metastasize. Angiosarcomas spontaneously develop in the deleted () zebrafish mutant. Read More

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Primary Angiosarcoma of the Adrenal Gland: Report of 2 Cases and Review of the Literature.

Int J Surg Pathol 2021 May 24:10668969211020099. Epub 2021 May 24.

8789University of California Davis, Sacramento, USA.

Primary adrenal angiosarcoma is a rare, malignant, vascular neoplasm. These neoplasms typically arise in middle age (median age of 60 years) and are more common in males (65%) than in females. Although rare, these neoplasms are aggressive with a propensity for local recurrence and metastasis and a median survival of 18 months. Read More

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A Rare Cause of Pulmonary Nodules Diagnosed as Angiosarcoma Was Misdiagnosed as Vasculitis and Wegener's Granuloma in an Elderly Man: A Case Report.

Front Oncol 2021 5;11:629597. Epub 2021 May 5.

Department of Geriatrics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Angiosarcoma is a rare, highly malignant tumor prone to recurrence and metastasis. Angiosarcoma is insidious in the initial stage, and its clinical manifestation lacks specificity. The diagnosis is based on histopathology and immunohistochemistry findings. Read More

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KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma.

J Genet Genomics 2021 Mar 10. Epub 2021 Mar 10.

Laboratory of Comparative Pathology, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan.

Epigenetic regulators have been implicated in tumorigenesis of many types of cancer; however, their roles in endothelial cell cancers such as canine hemangiosarcoma (HSA) have not been studied. In this study, we find that lysine-specific demethylase 2b (KDM2B) is highly expressed in HSA cell lines compared with normal canine endothelial cells. Silencing of KDM2B in HSA cells results in increased cell death in vitro compared with the scramble control by inducing apoptosis through the inactivation of the DNA repair pathways and accumulation of DNA damage. Read More

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Aberrant cytoplasmic connexin43 expression as a helpful marker in vascular neoplasms.

J Cutan Pathol 2021 May 21. Epub 2021 May 21.

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Background: Gap junctions consisting of connexins (Cx) are fundamental in controlling cell proliferation, differentiation, and cell death. Cx43 is the most broadly expressed Cx in humans and is attributed an important role in skin tumor development. Its role in cutaneous vascular neoplasms is yet unknown. Read More

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Breast Sarcomas, Phyllodes Tumors, and Desmoid Tumors: Epidemiology, Diagnosis, Staging, and Histology-Specific Management Considerations.

Am Soc Clin Oncol Educ Book 2021 Mar;41:390-404

Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

Breast sarcomas arise from connective tissues of the breast and account for fewer than 1% of all breast malignancies. They can be subclassified as primary breast sarcomas, which arise de novo and are histologically diverse, and secondary breast sarcomas, which arise as a result of radiation or lymphedema and are most commonly angiosarcomas. Two other connective tissue neoplasms that occur within the breast include phyllodes tumors and desmoid tumors, which exhibit a spectrum of behaviors. Read More

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