2,618 results match your criteria Angiomyolipoma Kidney


A Genome-Wide Association Study implicates in Lymphangioleiomyomatosis Pathogenesis.

Eur Respir J 2019 Apr 18. Epub 2019 Apr 18.

Division of Pulmonary and Critical Care Medicine and of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

Rationale: Lymphangioleiomyomatosis occurs either associated with Tuberous Sclerosis Complex or as sporadic disease (S-LAM). Risk factors for development of S-LAM are unknown.

Objectives: We hypothesised that DNA sequence variants outside of / might be associated with susceptibility for S-LAM, and performed a Genome Wide Association Study (GWAS). Read More

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00329
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http://dx.doi.org/10.1183/13993003.00329-2019DOI Listing
April 2019
1 Read

Deceased Donor Renal Transplantation Combined with Bilateral Nephrectomy in a Patient with Tuberous Sclerosis and Renal Failure.

Case Rep Transplant 2019 6;2019:2172163. Epub 2019 Mar 6.

Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Introduction: A 27-year-old female patient with known tuberous sclerosis complex (TSC), polycystic kidneys with multiple large bilateral angiomyolipomas, and failing renal functions with prehemodialysis values (urea: 19 mmol/L; creatinine: 317 mol/L; CKD-EPI 0,27) was admitted to our department for pre-renal transplant evaluation. The patient was placed on the transplant waiting list as the living donor did not pass pretransplant workup and was subsequently contraindicated. Patient was placed on the "cadaverous kidney transplant waiting list". Read More

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http://dx.doi.org/10.1155/2019/2172163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431358PMC
March 2019
1 Read

Pediatric Renal Neoplasms:: MR Imaging-Based Practical Diagnostic Approach.

Magn Reson Imaging Clin N Am 2019 May;27(2):279-290

Department of Radiology, Seattle Children's, University of Washington, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA.

Pediatric renal tumors may be malignant or benign. Wilms tumor, the most common malignant pediatric renal tumor, arises sporadically or with various syndromes. Renal cell carcinoma typically presents in older children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10649689193000
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http://dx.doi.org/10.1016/j.mric.2019.01.006DOI Listing
May 2019
5 Reads

Angiomyolipoma of the Adrenal Glands.

Clin Genitourin Cancer 2019 Feb 13. Epub 2019 Feb 13.

Department of Diagnostic Radiology, University of Illinois at Chicago, Chicago, IL. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2019.02.004DOI Listing
February 2019

New radiologic classification of renal angiomyolipoma: frequently asked questions.

Clin Imaging 2019 Feb 1;55:156-160. Epub 2019 Feb 1.

Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Recently, a new classification of renal angiomyolipoma (AML) has been introduced to clinical practice. This classification categorizes AMLs into three subtypes (fat-rich, fat-poor, and fat-invisible AMLs) based on quantitative CT and MRI criteria. Radiologists who get used to previous AML classification may have questions about how to apply a new classification. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.01.025DOI Listing
February 2019

Our experience in emergency treatment of renal haemorrhage.

Nefrologia 2019 Feb 23. Epub 2019 Feb 23.

Servei d'Angiologia, Cirurgia Vascular i Endovascular, Hospital Universitari Joan XXIII, Tarragona, España.

Introduction: Renal haemorrhage is a potentially life-threatening event requiring emergency surgery. Endovascular therapy is currently the first-line treatment option.

Objectives: Review patients with renal haemorrhage who required emergency endovascular therapy at our center. Read More

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http://dx.doi.org/10.1016/j.nefro.2018.10.010DOI Listing
February 2019
1 Read

Renal Epithelioid Angiomyolipoma Undergoing Aggressive Clinical Outcome: The MDM2 Expression in Tumor Cells of Two Cases.

Tohoku J Exp Med 2019 02;247(2):119-127

Department of Anatomic Pathology, Tohoku University Graduate School of Medicine.

Epithelioid angiomyolipoma (EAML) has been known as a potentially malignant tumor which occasionally recur and/or metastasize to other organs, and clinically and pathologically recognized as distinct entity. However, the mechanisms of recurrence and/or metastasis (recurrence/metastasis) has still remained unknown. Here, we report two cases of renal EAML associated with recurrence/metastasis, and three cases of EAML in kidney or liver without recurrence/metastasis. Read More

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http://dx.doi.org/10.1620/tjem.247.119DOI Listing
February 2019

Diagnostic Imaging for Solid Renal Tumors: A Pictorial Review.

Kidney Cancer 2018 Aug 1;2(2):79-93. Epub 2018 Aug 1.

Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.

The prognosis of renal tumors depends on histologic subtype. The increased use of abdominal imaging has resulted in an increase in the number of small renal incidentaloma in recent decades. Of these incidentally discovered tumors, 20% are benign lesions warranting conservative management, but most are renal cell carcinomas that warrant a more aggressive therapeutic approach due to their malignant potential. Read More

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http://dx.doi.org/10.3233/KCA-180028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364093PMC
August 2018
1 Read

Tsc1 ablation in Prx1 and Osterix lineages causes renal cystogenesis in mouse.

Sci Rep 2019 Jan 29;9(1):837. Epub 2019 Jan 29.

Department of Ophthalmology, XinHua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Tuberous Sclerosis Complex (TSC) is caused by mutations in TSC1 or TSC2, which encode negative regulators of the mTOR signaling pathway. The renal abnormalities associated with TSC include angiomyolipoma, cysts, and renal cell carcinoma. Here we report that specific ablation of Tsc1 using the mesenchymal stem cell-osteoblast lineage markers induced cystogenesis in mice. Read More

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http://www.nature.com/articles/s41598-018-37139-9
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http://dx.doi.org/10.1038/s41598-018-37139-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351533PMC
January 2019
9 Reads

Effect of histopathologic characteristics on pseudocapsular invasion in the case of partial nephrectomy for renal tumours.

Asian J Surg 2019 Mar 26;42(3):507-513. Epub 2019 Jan 26.

Ministry of Health, Diskapi Yildirim Beyazid Education and Research Hospital, Department of Urology, Ankara, Turkey.

Objective: It is aimed to define the existence of pseudocapsular structure on renal tumours, illuminate the relation between pseudocapsular invasion and Fuhrman grade histological type that are among histopathologic prognostic risk factors and determine the relation between surgical margin positivity and existence of pseudocapsular invasion. Sequential partial nephrectomy series and relevant pathological preparations were retrospectively reviewed in order to evaluate these issues.

Methods: The study includes 123 patients diagnosed with T1 renal tumour and treated with partial nephrectomy in between January 2007 and June 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10159584183060
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http://dx.doi.org/10.1016/j.asjsur.2018.12.001DOI Listing
March 2019
11 Reads

Imaging of Unusual Renal Tumors.

Curr Urol Rep 2019 Jan 21;20(1). Epub 2019 Jan 21.

Department of Radiology, University of Miami/Miller School of Medicine, 1611 NW 12th Avenue, Miami, FL, 33136, USA.

Purpose Of Review: Renal masses are a wide entity and a common finding in clinical practice. Detection of these masses has increased in the last years, yet mortality rates have slightly decreased.

Recent Findings: According to the World Health Organization classification, there are 8 types, 51 subtypes, and a lot more subsequent subclassifications of renal tumors. Read More

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http://link.springer.com/10.1007/s11934-019-0867-7
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http://dx.doi.org/10.1007/s11934-019-0867-7DOI Listing
January 2019
8 Reads

Late local, peritoneal and systemic recurrence of renal angiomyolipoma: A case report.

Mol Clin Oncol 2019 Jan 31;10(1):43-48. Epub 2018 Oct 31.

Department of Pathology, Medical School of Crete University Hospital, 71110 Heraklion, Greece.

Renal angiomyolipoma (AML) is a relatively rare tumor that is generally considered as merely benign. However, epithelioid AML (EAML), an uncommon subtype, is associated with potentially malignant behavior. We herein present the case of a 60-year old male patient who had undergone left nephrectomy with left adrenalectomy and lymphadenectomy for a renal tumor 12 years earlier, and presented to our hospital with dull abdominal pain. Read More

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http://dx.doi.org/10.3892/mco.2018.1755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313948PMC
January 2019

Renal Angiomyolipoma Based on New Classification: How to Differentiate It From Renal Cell Carcinoma.

Authors:
Byung Kwan Park

AJR Am J Roentgenol 2019 Mar 8;212(3):582-588. Epub 2019 Jan 8.

1 Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul, 135-710, Republic of Korea.

Objective: The purpose of this article is to describe useful imaging features for differentiating angiomyolipoma (AML) subtypes from renal cell carcinoma subtypes.

Conclusion: A newer radiologic classification of renal AML consists of fat-rich AML (≤ -10 HU), fat-poor AML (> -10 HU; tumor-to-spleen ratio < 0.71; signal intensity index, > 16. Read More

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http://dx.doi.org/10.2214/AJR.18.20408DOI Listing
March 2019
1 Read

An unusual case of tuberous sclerosis incidentally discovered in adulthood: case report and review of the literature.

Acta Radiol Open 2018 Dec 6;7(12):2058460118806328. Epub 2018 Dec 6.

Department of Advanced Biomedical Sciences, University "Federico II," Naples, Italy.

Tuberous sclerosis (TS) is a relatively rare multi-organ disorder generally diagnosed in infancy and described as a clinical triad of sebaceous adenoma, mental retardation, and seizures. Angiomyolipoma (AML) is the most common benign renal tumor usually found incidentally as a solitary small echogenic lesion on grayscale ultrasound. Less commonly, it is part of the TS complex and is seen as multiple lesions in both kidneys. Read More

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http://dx.doi.org/10.1177/2058460118806328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299912PMC
December 2018
3 Reads

[The 467th case: proteinuria, periungual fibromas, and facial steatadenomas].

Zhonghua Nei Ke Za Zhi 2019 Jan;58(1):74-77

Department of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.

A 22-year-old manpresented as a refractory nephrotic syndrome with edema and proteinuria for more than one year. Physical examination revealed facial steatadenomas and periungual fibromas. Images were characterized by hamartomatous lesions in multiple organs, including the central nervous system, heart, lungs, liver, and kidneys. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.01.014DOI Listing
January 2019
2 Reads

Use of a mixture of Lipiodol and Cyanoacrylate in percutaneous embolization treatment of symptomatic renal Angiomyolipomas: Our experience.

Radiol Case Rep 2019 Mar 13;14(3):343-347. Epub 2018 Dec 13.

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Via S. Camillo 8, 98122 Messina, Italy.

Purpose of this report is to describe safety and effectiveness of selective artery embolization in the treatment of bleeding angiomyolipomas (AMLs) of the kidney using a mixture of Lipiodol and Cyanoacrylate. Two patients with bleeding AMLs underwent to superselective embolization of the lesions using microcatheter and Lipiodol mixed with Cyanoacrylate in the ratio 3:1. Primary bleeding control rate was 100% with no major complications. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297069PMC
March 2019
1 Read

Kidney transplantation from a living donor to a mentally disabled recipient with bilateral angiomyolipomas-A case report.

Int J Surg Case Rep 2018 24;53:444-447. Epub 2018 Nov 24.

Clinic for Obstetrics and Reproduction, Faculty of Veterinary Medicine, University of Zagreb, Croatia. Electronic address:

Introduction: Many centers do not perform transplantation in mentally disabled people. Our patient with progressive psychomotor developmental delay had bilateral angiomyolipomas.

Presentation Of The Case: Three years ago she underwent a right nephrectomy for massive spontaneous hemorrhage. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275201PMC
November 2018
1 Read

Giant renal angiomyolipoma in a solitary kidney.

Can J Urol 2018 12;25(6):9614-9616

Department of Urology, Stanford University, Stanford, California, USA.

While renal angiomyolipomas (AMLs) generally remain small and asymptomatic, larger AMLs are more common in tuberous sclerosis patients. Giant AMLs over 20 cm are a rare entity and little is known about their management. We present a unique case of a 48-year-old woman with tuberous sclerosis and a 39 cm AML arising from a solitary kidney, after undergoing nephrectomy for a prior AML. Read More

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December 2018
2 Reads

Dia-gnostic Challenges and Extraordinary Treatment Response in Rare Malignant PEComa Tumor of the Kidney.

Klin Onkol 2018 ;31(6):448-452

Background: Epithelioid angiomyolipoma (EAML) of the kidney, in contrast to classic benign renal angiomyolipoma, is a rare mesenchymal neoplasm with malignant potential. Represent-ing a member of the perivascular epithelioid cells (PEComa) tumor family aris-ing from the perivascular epithelioid cells, its accurate dia-gnosis and therapeutic approach remains challenging.

Methods: We report a case of a patient with malignant EAML, initially treated as renal cell carcinoma (RCC) at our institution. Read More

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http://dx.doi.org/10.14735/amko2018448DOI Listing
January 2018
1 Read

Can we predict the existence of extrarenal feeders to renal angiomyolipomas?

Eur Radiol 2019 May 12;29(5):2499-2506. Epub 2018 Dec 12.

Department of Radiology, School of Medicine, Juntendo University, Tokyo, Japan.

Objectives: To identify factors predicting the presence of extrarenal feeders to renal angiomyolipomas (AMLs) METHODS: This is a retrospective study of 44 patients with 58 renal AMLs embolized in our department. Arteriography obtained during embolization and CT angiography obtained before and after embolization were reviewed to characterize AMLs with and without extrarenal feeders. Tumor characteristics were compared between the two groups. Read More

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http://dx.doi.org/10.1007/s00330-018-5877-1DOI Listing

Percutaneous microwave ablation of renal angiomyolipomas in tuberous sclerosis complex to improve the quality of life: preliminary experience in an Italian center.

Radiol Med 2019 Mar 11;124(3):176-183. Epub 2018 Dec 11.

Diagnostic and Interventional Radiology Department, ASST Santi Paolo e Carlo, San Paolo Hospital, University of Milan, Via A di Rudinì 8, 20142, Milan, Italy.

Aim: To evaluate efficacy, safety and quality of life of the patients with renal angiomyolipomas (AMLs) associated with tuberous sclerosis complex (TSC) treated with percutaneous microwave ablation (MWA).

Materials And Methods: Nine patients (7 females and 2 males; mean age 27.6 years, range 23-34), with 10 renal AMLs with a mean size of 6. Read More

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http://dx.doi.org/10.1007/s11547-018-0967-3DOI Listing
March 2019
2 Reads

[Magnetic resonance imaging findings and differential diagnosis of renal epithelioid angiomyolipoma comparing with renal no-epithelioid angiomyolipoma].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(45):3701-3704

Department of X-ray, the Affiliated Chinese Medical Hospital of Southwest Medical University, Luzhou 646300, China.

To investigate whether MRI findings can differentiate renal epithelioid angiomyolipoma (EAML) from renal no-epithelioid (typical) angiomyolipoma. A total of 44 patients were collected from General Hospital of PLA.These cases were obtained from January 2009 to June 2015. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.45.014DOI Listing
December 2018
2 Reads

Observational study of characteristics and clinical outcomes of Dutch patients with tuberous sclerosis complex and renal angiomyolipoma treated with everolimus.

PLoS One 2018 15;13(11):e0204646. Epub 2018 Nov 15.

Groupe d'analyse, Ltée, Montréal, QC, Canada.

Objective: To compare kidney size (used as proxy for total renal angiomyolipoma [rAML] size) and kidney function outcomes between patients with tuberous sclerosis complex (TSC) and rAML treated and not treated with everolimus.

Methods: Medical charts of adults with TSC-associated rAML followed at a specialty medical center in the Netherlands (1990-2015). Included patients treated with everolimus (n = 33, of which 27 were included in the kidney size analyses and 27 in the kidney function analyses [21 patients in both]; index date = everolimus initiation) and non-treated patients (n = 39, of which 29 were included in the kidney size analyses and 33 in the kidney function analyses [23 patients in both]; index date = one date among all dates with outcome measurement). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204646PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237294PMC
April 2019
15 Reads

Giant exophytic renal angiomyolipoma masquerading as a retroperitoneal liposarcoma: A case report and review of literature.

World J Clin Oncol 2018 Nov;9(7):162-166

Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Delhi 110095, India.

A 42-years-old lady, presented with a large retroperitoneal mass which was preoperatively diagnosed as a retroperitoneal liposarcoma following an image guided core biopsy. She underwent a margin-negative resection of the retroperitoneal mass (multi visceral resection - enbloc excision of the retroperitoneal mass with a left nephrectomy and a segmental descending colectomy). The final histopathological examination of the resected specimen confirmed an exophytic renal angiomyolipoma (AML) which was extending into the retroperitoneum. Read More

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http://dx.doi.org/10.5306/wjco.v9.i7.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230916PMC
November 2018
5 Reads

Does epithelioid angiomyolipoma have poorer prognosis, compared with classic angiomyolipoma?

Investig Clin Urol 2018 11 4;59(6):357-362. Epub 2018 Oct 4.

Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Classic angiomyolipoma (AML) is common benign kidney tumor. However, some studies have claimed that epithelioid angiomyolipoma (EAML) has malignant potential. We compared the patient characteristics and prognosis of EAML and classic AML to demonstrate predicting factors and poorer prognosis of EAML. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4111/icu.2018.59
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http://dx.doi.org/10.4111/icu.2018.59.6.357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215778PMC
November 2018
20 Reads

Evaluation of ABO blood groups and blood-based biomarkers as a predictor of growth kinetics of renal angiomyolipoma.

Int Urol Nephrol 2018 Dec 15;50(12):2131-2137. Epub 2018 Oct 15.

Department of Urology, Istanbul Taksim Gaziosmanpasa Training and Research Hospital, Karayolları Str. No:621, Gaziosmanpaşa, Istanbul, Turkey.

Purpose: The aim of our study was to investigate the impact of the ABO blood groups and blood-based biomarkers on the growth kinetics of renal angiomyolipoma (AML).

Methods: A total of 124 patients with AML who were followed-up between 2010 and 2018 were retrospectively reviewed. The patients' characteristics were recorded, including age, body mass index (BMI), blood pressure, smoking history, and ABO blood group. Read More

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http://dx.doi.org/10.1007/s11255-018-2012-9DOI Listing
December 2018

Renal manifestation of tuberous sclerosis complex.

Am J Med Genet C Semin Med Genet 2018 Sep 11;178(3):338-347. Epub 2018 Oct 11.

Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Centre, St. Georges University of London, London, United kingdom.

Tuberous sclerosis complex (TSC) is a tumor predisposition syndrome with significant renal cystic and solid tumor disease. It commonly causes several types of cystic disease and benign tumors (angiomyolipomata) in the kidneys that can both lead to significant premature loss of glomerular filtration rate. The main risks of angiomyolipomata, severe bleeding, loss of renal function, and pulmonary lymphangioleiomyomatosis, can be ameliorated by active surveillance and preemptive therapy with mTOR inhibitors. Read More

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http://doi.wiley.com/10.1002/ajmg.c.31654
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http://dx.doi.org/10.1002/ajmg.c.31654DOI Listing
September 2018
16 Reads

Burden of renal angiomyolipomas associated with tuberous sclerosis complex: results of a patient and caregiver survey.

J Patient Rep Outcomes 2018 Dec 13;2:30. Epub 2018 Jul 13.

6Le Bonheur Children's Hospital and the University of Tennessee, Memphis, TN USA.

Background: Tuberous sclerosis complex (TSC) is a rare genetic disorder characterized by benign tumors in multiple organs, including non-cancerous kidney lesions known as renal angiomyolipomas. This study's objective is to describe the age-stratified morbidity, treatment patterns, and health-related quality of life of TSC patients with renal angiomyolipomas in the United States. A cross-sectional, anonymous web-based survey was conducted with a convenience sample of TSC patients and caregivers identified through a patient advocacy organization. Read More

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https://jpro.springeropen.com/articles/10.1186/s41687-018-00
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http://dx.doi.org/10.1186/s41687-018-0055-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091699PMC
December 2018
12 Reads

Benign Neoplasm of Kidney: Angiomyolipoma.

J Med Ultrasound 2018 Jul-Sep;26(3):119-122. Epub 2018 Sep 14.

Division of Urology, Department of Surgery, Cathay General Hospital, Taipei, Taiwan.

Angiomyolipoma is one of the renal benign neoplasms. The most of the angiomyolipomas are asymptomatic and found incidentally with ultrasound. They are more prevalent in patients with tuberous sclerosis. Read More

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http://www.jmuonline.org/text.asp?2018/26/3/119/241145
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http://dx.doi.org/10.4103/JMU.JMU_48_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159326PMC
September 2018
4 Reads

A new drug combination significantly reduces kidney tumor progression in kidney mouse model.

Oncotarget 2018 Aug 31;9(68):32900-32916. Epub 2018 Aug 31.

Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, Bio-X Institutes, San Antonio, TX, USA.

Tuberous sclerosis complex (TSC) disease is associated with tumors in many organs, particularly angiomyolipoma (AML) in the kidneys. Loss or inactivation of results in high levels of HIF-α activity and VEGF expression. mTOR inhibitor (rapamycin) and the AMPK activator 5-aminoimidazole-4-carboxamide (AICA)-riboside (AICAR) are currently used separately to treat cancer patients. Read More

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http://dx.doi.org/10.18632/oncotarget.26004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152473PMC
August 2018
5 Reads

Renal disease in tuberous sclerosis complex: pathogenesis and therapy.

Nat Rev Nephrol 2018 Nov;14(11):704-716

Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by hamartomatous tumours of the brain, heart, skin, lung and kidney. Patients with TSC show a diverse range of neurological features (including seizures, cognitive disability and autism) and renal manifestations (including angiomyolipomas, epithelial cysts and renal cell carcinoma (RCC)). TSC is caused by inactivating mutations in TSC1 and TSC2, which encode hamartin and tuberin, respectively. Read More

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http://www.nature.com/articles/s41581-018-0059-6
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http://dx.doi.org/10.1038/s41581-018-0059-6DOI Listing
November 2018
10 Reads

Evaluation of diagnostic accuracy and a practical algorithmic approach for the diagnosis of renal masses by FNA.

Cancer Cytopathol 2018 Sep 7;126(9):782-796. Epub 2018 Sep 7.

Department of Pathology, Stanford University School of Medicine, Stanford, California.

Background: The classification of renal neoplasms is essential for oncologic risk stratification and clinical management, and an accurate pretreatment pathologic diagnosis can provide useful guidance for active surveillance, minimally invasive ablative therapy, or surgical resection and can reduce the incidence of overtreatment. Previous studies evaluating the diagnostic accuracy of fine-needle aspiration (FNA) and core-needle biopsy (CNB) for renal masses are limited and show variable results.

Methods: Two hundred forty-seven renal FNA cases with or without concurrent CNB performed and/or reviewed at the Stanford University School of Medicine over the course of 20 years were identified. Read More

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http://dx.doi.org/10.1002/cncy.22037DOI Listing
September 2018
3 Reads

Angiomyolipoma rebound tumor growth after discontinuation of everolimus in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis.

PLoS One 2018 7;13(9):e0201005. Epub 2018 Sep 7.

Schlumberger Moscow Research Center, Moscow Research Institute of Pediatrics and Pediatric Surgery, Moscow, Russian Federation.

Introduction: The EXIST-2 (NCT00790400) study demonstrated the superiority of everolimus over placebo for the treatment of renal angiomyolipomas associated with tuberous sclerosis complex (TSC) or sporadic lymphangioleiomyomatosis (LAM). This post hoc analysis of EXIST-2 study aimed to assess angiomyolipoma tumor behavior among patients who submitted to continued radiographic examination following discontinuation of everolimus in the noninterventional follow-up phase.

Methods: For patients who discontinued everolimus at the completion of extension phase for reasons other than angiomyolipoma progression, a single CT/MRI scan of the kidney was collected after 1 year of treatment discontinuation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201005PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128468PMC
February 2019
17 Reads

Large Aneurysm in Renal Angiomyolipoma.

J Coll Physicians Surg Pak 2018 Sep;28(9):S160-S161

Department of Radiology, Civil Hospital and Dow University of Health Sciences, Karachi.

Large aneurysms seen in renal angiomyolipoma are usually more common in patients with tuberous sclerosis in comparison with sporadic cases and they are more prone to hemorrhage ranging from renal hematoma to life-threatening perirenal hemorrhages. We present a case of 13-year female patient who was referred to Civil Hospital, Karachi, with bilateral flank pain, cutaneous nodule and low intelligence. Her color doppler ultrasound revealed pseudoaneurysm in left kidney on the background of bilateral renal angiomyolipomas. Read More

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http://dx.doi.org/10.29271/jcpsp.2018.09.S160DOI Listing
September 2018
19 Reads

Immunohistochemical Pitfalls in Genitourinary Pathology: 2018 Update.

Adv Anat Pathol 2018 Nov;25(6):387-399

Robert J. Tomsich Institute of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH.

Immunohistochemistry may be a very useful adjunct to morphologic diagnosis in many areas of surgical pathology, including genitourinary pathology. In this review, we address common diagnostic dilemmas where immunophenotypic analysis may be utilized and we highlight pitfalls specific to each scenario. For prostate, we review the diagnosis of limited prostatic adenocarcinoma and the distinction of high-grade prostatic adenocarcinoma from urothelial carcinoma. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000205DOI Listing
November 2018
7 Reads

Ancillary studies in fine needle aspiration of the kidney.

Cancer Cytopathol 2018 Aug;126 Suppl 8:711-723

Baptist Hospital of Miami and Miami Cancer Institute, Miami, Florida.

An increasing number of renal cell carcinomas (RCCs) require ancillary studies for diagnosis. The majority of renal fine needle aspirates do not require ancillary studies. Among the most common useful stains are cytokeratin 7 (separating clear cell RCC [negative] from papillary RCC, clear cell papillary RCC, and multilocular cystic RCC [positive] as well as separating chromophobe RCC [diffusely positive] from oncocytoma [focally positive/negative]) and CD117 (separating chromophobe RCC and oncocytoma [positive] from granular variants of clear cell RCC [negative]). Read More

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http://dx.doi.org/10.1002/cncy.22029DOI Listing
August 2018
23 Reads

[Minimal fat renalangiomyolipoma with multiple lymph nodes enlargement and postoperative refractory lymphatic fistula: a case report and literature review].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Aug;50(4):717-721

Department of Urology, Peking University People's Hospital, Beijing 100044, China.

Renal angiomyolipoma (AML) is a common benign tumor in the urinary system, mainly composed of adipose tissue, blood vessels and muscle tissue. Renal AML is sporadic in most of patients, while a few are associated with tuberous sclerosis. Classical renal AML occurs predominantly in middle-aged females. Read More

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August 2018
20 Reads

[Comparison of safety and effectiveness between retroperitoneal laparoscopic tumor aspiration and laparoscopic partial nephrectomy in the treatment of renal angiomyolipoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Aug;50(4):700-704

Department of Urology, Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center, Beijing 100034, China.

Objective: To compare the safety and treatment effectiveness of retroperitoneal laparoscopic tumor aspiration and laparoscopic partial nephrectomy (LPN) in the treatment of renal angiomyolipoma (RAML).

Methods: We retrospectively reviewed the clinical data of patients with pathologically confirmed RAML who received operation between August 2010 and August 2016 in the Department of Urology, Peking University First Hospital. Among them, a series of 121 patients were included in this trial according to the inclusion criteria, of which 74 cases could be collected and followed-up effectively. Read More

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August 2018
15 Reads

Primary angiosarcoma arising in an angiomyolipoma of the kidney: case report and literature review.

Diagn Pathol 2018 Aug 16;13(1):53. Epub 2018 Aug 16.

Department of Pathology, Dalian Medical University First Hospital, 222 Zhongshan Road, Xigang District, Dalian, 116011, Liaoning, China.

Background: Primary angiosarcoma of the kidney is a rare and aggressive malignant tumor presenting with a recognizable vascular differentiation. Its prognosis is fatal and the pathogenesis remains unclear. Renal angiomyolipoma is a relatively infrequent renal cortical neoplasm and is composed of variable proportions of adipose tissue, spindle cells, epithelioid smooth muscle cells and abnormal thick-walled blood vessels. Read More

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http://dx.doi.org/10.1186/s13000-018-0730-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094454PMC
August 2018
14 Reads

Prophylactic selective arterial embolization for renal angiomyolipomas: efficacy and evaluation of predictive factors of significant shrinkage.

Int Urol Nephrol 2018 Oct 12;50(10):1765-1770. Epub 2018 Aug 12.

Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, 8 Xishiku St, Beijing, 100034, People's Republic of China.

Purpose: To evaluate the efficacy of prophylactic selective arterial embolization (SAE) of angiomyolipomas (AMLs) and to find out predictive factors of significant shrinkage of AMLs after SAE.

Methods: Patients receiving prophylactic SAE for renal AMLs with complete medical records were included. The changes of the size, urine erythrocyte counts, and serum creatinine of all patients pre- and post-embolization were assessed. Read More

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http://link.springer.com/10.1007/s11255-018-1953-3
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http://dx.doi.org/10.1007/s11255-018-1953-3DOI Listing
October 2018
26 Reads

Primary kidney malignant epithelioid angiomyolipoma: Two cases report and review of literature.

Medicine (Baltimore) 2018 Aug;97(32):e11805

Department of Pathology, First People's Hospital of Wujiang District, Suzhou.

Rationale: Epithelioid angiomyolipoma (EAML) is a subtype of angiomyolipoma with malignant potential. A diagnosis of malignant EAML of the kidney is based on extrarenal metastasis, and predicting early transformation is difficult. To propose criteria for indicators of malignant transformation, herein we report 2 cases and review 17 cases reported in the literature (2000-2017). Read More

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http://dx.doi.org/10.1097/MD.0000000000011805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133394PMC
August 2018
29 Reads

Effect of everolimus treatment for regrown renal angiomyolipoma associated with tuberous sclerosis complex after transcatheter arterial embolization.

Int J Clin Oncol 2018 Dec 1;23(6):1134-1139. Epub 2018 Aug 1.

Department of Urology, Jikei University School of Medicine, Tokyo, Japan.

Background: The aim of this study was to evaluate the effects and the utility of second-line everolimus treatment for regrown renal angiomyolipoma (AML) with tuberous sclerosis complex (TSC) after transcatheter arterial embolization (TAE).

Methods: We investigated a total of 14 patients who underwent second-line everolimus treatment for TSC-AML that regrew after TAE, and assessed their effects and adverse events. Everolimus treatment was performed for AML with a maximum diameter of 4 cm. Read More

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http://dx.doi.org/10.1007/s10147-018-1325-0DOI Listing
December 2018
2 Reads

Disseminated Intravascular Coagulation After Embolization to Treat Acutely Bleeding Bilateral Massive Angiomyolipoma: A Case Report.

J Endourol Case Rep 2018 1;4(1):117-119. Epub 2018 Jul 1.

Department of Urology, The Royal Adelaide Hospital, Adelaide, Australia.

Hemorrhage from an angiomyolipoma (AML) of the kidney can be life threatening and arterial embolization is the primary treatment. Embolization is less invasive than surgery, is well tolerated, and major complications are rare. We describe a case of disseminated intravascular coagulation (DIC) after embolization of a bleeding renal AML in a 44-year-old man with massive bilateral AMLs. Read More

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http://dx.doi.org/10.1089/cren.2018.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064195PMC
July 2018
6 Reads

[Renal Angiomyolipoma Extending into the Renal Vein --A Case Report-].

Hinyokika Kiyo 2018 May;64(5):213-217

The Department of Urology, Tokushima University Hospital.

We report a case of left renal angiomyolipoma extending into the renal vein. A 67-year-old woman showed a left renal tumor which was 6 cm in diameter and had density equal to fat tissue in computed tomography. We suspected liposarcoma and performed radical nephrectomy and resection of thrombus. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_5_213DOI Listing
May 2018
7 Reads

Efficacy and Safety of Mammalian Target of Rapamycin Inhibitor Use-Long-term Follow-up of First Tuberous Sclerosis Complex Patient Treated De Novo With Sirolimus After Kidney Transplantation: A Case Report.

Transplant Proc 2018 Jul - Aug;50(6):1904-1909. Epub 2018 Mar 15.

Department of Urology, Medical University of Gdańsk, Gdańsk, Poland.

Mammalian target of rapamycin inhibitors (mTORI) are increasingly used in the treatment of tuberous sclerosis complex (TSC) and as immunosuppressants after organ transplantation. In TSC patients, mTORI are the treatment of choice after kidney transplantation. It is still under debate if benefits from long-term mTORI use will not be limited by side effects. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.03.028DOI Listing
October 2018
12 Reads

Imaging of Solid Renal Masses.

Urol Clin North Am 2018 Aug 15;45(3):311-330. Epub 2018 Jun 15.

Department of Radiology; UT Southwestern Medical Center, 2201 Inwood Road, Suite 210, Dallas, TX 75390, USA. Electronic address:

The increase in serendipitous detection of solid renal masses on imaging has not resulted in a reduction in mortality from renal cell carcinoma. Consequently, efforts for improved lesion characterization have been pursued and incorporated into management algorithms for distinguishing clinically significant tumors from those with favorable histology or benign conditions. Although diagnostic imaging strategies have evolved for optimized lesion detection, distinction between benign tumors and both indolent and aggressive malignant neoplasms remain an important diagnostic challenge. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057157PMC
August 2018
23 Reads

Renal progression factors in young patients with tuberous sclerosis complex: a retrospective cohort study.

Pediatr Nephrol 2018 Nov 9;33(11):2085-2093. Epub 2018 Jul 9.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Background: Renal pathology in tuberous sclerosis complex (TSC) is characterized by the growth of angiomyolipoma and renal cysts, and in rare cases renal cell carcinoma. Other consequences of renal involvement in TSC, including hypertension, proteinuria, and hyperfiltration, are not well studied. We aimed to analyze the early manifestations of the renal TSC phenotype in a young TSC cohort and to explore common, modifiable risk factors. Read More

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http://dx.doi.org/10.1007/s00467-018-4003-6DOI Listing
November 2018
11 Reads

Gemstone spectral imaging dual-energy computed tomography for differentiation of renal cell carcinoma and minimal-fat renal angiomyolipoma.

J Cancer Res Ther 2018 Jun;14(Supplement):S394-S399

Department of Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China.

Purpose: To investigate the values of gemstone spectral imaging (GSI)-dual-energy computed tomography (DECT) in differentiation of renal cell carcinoma (RCC) and minimal-fat renal angiomyolipoma (MF-RAML).

Patients And Methods: Twenty-one patients with ischemic RCC and 19 patients with MF-RAML were enrolled in this study. GSI was performed on them, and the spectrum signs were analyzed. Read More

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http://www.cancerjournal.net/text.asp?2018/14/9/394/172714
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http://dx.doi.org/10.4103/0973-1482.172714DOI Listing
June 2018
4 Reads