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Br J Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Departments of Dermatology, St George's Hospital, Tooting, London, UK.

A 30-year-old Caucasian woman with no relevant medical history or family history presented to dermatology with a benign fibrous papule on her nose and was incidentally found to have an unusual rash on her legs. It had developed after birth, was itchy and aggravated by hot weather. She had no previous miscarriages and had a healthy 2-year-old daughter. Read More

Australas J Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.

Int J Dermatol 2019 Mar 27;58(3):e62-e64. Epub 2018 Nov 27.

Department of Pathology, Dr Ram Manohar Lohia Hospital & Post Graduate Institute of Medical Education & Research, New Delhi, India.

J Clin Aesthet Dermatol 2018 May 1;11(5):43-47. Epub 2018 May 1.

Dr. Tas is with the Health Sciences University, Istanbul Bagcilar Research and Training Hospital, Department of Dermatology in Istanbul, Turkey.

We present the case of a 15-year-old girl who presented with an unusual grouping of lesions on her upper left leg. The lesions had been present since birth. The patient had five different types of lesions: 1) transparent grouped or scattered yellowish vesicles; 2) keratotic-surfaced, grouped dark-yellowish papules; 3) bright-red grouped papules; 4) keratotic-surfaced grouped dark-red papules; and 5) patchy, punctate, and erythematous red macules. Read More

Indian Dermatol Online J 2018 Mar-Apr;9(2):127-129

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

Indian J Dermatol Venereol Leprol 2018 May-Jun;84(3):338-341

Department of Pathology, University College of Medical Sciences, GTB Hospital, University of Delhi, New Delhi, India.

J Cutan Med Surg 2018 Sep/Oct;22(5):511-513. Epub 2018 Feb 9.

1 Hospital For Sick Children, Toronto, ON, Canada.

Background: Angioma serpiginosum (AS) is a rare vascular abnormality consisting of proliferation and dilation of superficial blood vessels in the skin. AS typically presents in the first 2 decades of life and remains stable with time.

Case Summary: We report the case of a 13-year-old female with an acquired, recurrent erythematous lesion with serpiginous borders on her left upper arm. Read More

Indian J Dermatol 2016 Sep-Oct;61(5):570-2

Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India. E-mail:

Indian J Dermatol Venereol Leprol 2016 Sep-Oct;82(5):588

Department of Pathology, Institute of Pathology, Indian Council of Medical Research, New Delhi, India.

Eur J Dermatol 2016 Jan-Feb;26(1):118

Department of Dermatology and Venereology, Hôpital de Beaumont, Lausanne University Hospital Center, CH-1011 Lausanne, Switzerland.

Indian J Dermatol Venereol Leprol 2016 May-Jun;82(3):335-7

Department of Dermatology, Venereology and Leprosy, BYL Nair Charitable Hospital and Topiwala National Medical College, Mumbai, Maharashtra, India.

Indian J Dermatol 2016 Mar-Apr;61(2):226-7

Department of Dermatology, Katihar Medical College, Katihar, Bihar, India.

An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):26-8

University Hospital of Fuenlabrada, Madrid, ES.

We report the case of a 35-year-old woman with deep-red asymptomatic macules on the plantar and dorsal skin of the right great toe. Histopathologic findings were compatible with Angioma serpiginosum. Immunohistochemical stains for estrogens and progesterone receptors were negative. Read More

J Dermatol 2015 Jul 11;42(7):750-1. Epub 2015 May 11.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

J Eur Acad Dermatol Venereol 2015 Dec 10;29(12):2295-305. Epub 2015 Apr 10.

Department of Dermatology, Freiburg University Medical Center, Freiburg, Germany.

The name capillary malformation has caused much confusion because it is presently used to designate numerous quite different disorders such as naevus flammeus, the salmon patch, the vascular naevus of the hereditary 'megalencephaly-capillary malformation syndrome' and the skin lesions of non-hereditary traits such as 'capillary malformation-arteriovenous malformation' and 'microcephaly-capillary malformation'. To avoid such bewilderment, the present review describes the distinguishing clinical and genetic criteria of 20 different capillary malformations, and a specific name is given to all of them. The group of capillary naevi includes naevus flammeus, port-wine naevus of the Proteus type, port-wine naevus of the CLOVES type, naevus roseus, rhodoid naevus, cutis marmorata telangiectatica congenita, congenital livedo reticularis, segmental angioma serpiginosum, naevus anaemicus, naevus vascularis mixtus and angiokeratoma circumscriptum. Read More

Int J Dermatol 2015 Mar;54(3):e88-9

Department of Dermatology, Afyonkarahisar Government Hospital, Afyonkarahisar, Turkey.

J Dermatol 2014 Nov 9;41(11):996-8. Epub 2014 Oct 9.

Leaders Aesthetic Laser and Cosmetic Surgery Center, Seoul, Korea.

Angioma serpiginosum (AS) is a rare, benign, vascular disorder comprising non-blanchable punctate red to purple lesions in a gyrate or serpiginous configuration. We report a case of a 38-year-old woman with a red colored eruption on her chest which was present since puberty. A novel 532 nm potassium-titanyl phosphate (KTP) laser (Excel V, Cutera Inc. Read More

Indian Dermatol Online J 2014 Jul;5(3):316-9

Department of Pathology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

Angioma serpiginosum is a cutaneous vascular nevoid disorder that presents as red, nonblanchable and grouped macules distributed in a serpiginous pattern and resembles purpura. It usually begins in childhood and commonly affects the lower limbs and the buttocks. Late onset of the lesions is unusual. Read More

Clin Exp Dermatol 2014 Aug 1;39(6):757-9. Epub 2014 Jul 1.

Department of Dermatology, Oklahoma University Health Sciences Center, Oklahoma City, OK, USA.

Int J Dermatol 2014 Dec 16;53(12):1505-7. Epub 2014 Apr 16.

Department of Dermatopathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Dermatol Online J 2014 Nov 16;21(2). Epub 2014 Nov 16.

Department of Dermatology, Hospital Universitario de Fuenlabrada, Madrid.

Angioma serpiginosum (AS) is an unusual vascular disorder that typically affects female patients, begins in childhood and stabilizes in adulthood and not frequently involve acral skin. We herein present a 13 year-old girl with an asymptomatic erythematous punctuate first noticed on the right palm three years ago, with a proximal serpiginous progression up to the forearm. On examination there was a nonblanching erythematous punctuate on the palm and the inner aspect of right hand and forearm. Read More

Arch Dermatol 2011 Jul;147(7):878

Duke University Medical Center, Durham, North Carolina, USA.

Dermatol Online J 2011 May 15;17(5). Epub 2011 May 15.

Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

We report on a 43-year-old Caucasian female who presented with bright red macules in a unilateral distribution in the left C5-8 and L3-5 dermatomes. Histopathologic examination showed superficial papillary dermal telangiectasia with minimal chronic inflammation. Immunohistochemical stains for estrogen and progesterone receptors (ER/PR) were negative. Read More

Hum Mutat 2011 Jul 21;32(7):723-8. Epub 2011 Jun 21.

Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Mutations in the PORCN gene were first identified in Goltz-Gorlin syndrome patients in 2007. Since then, several reports have been published describing a large variety of genetic defects resulting in the Goltz-Gorlin syndrome, and mutations or deletions were also reported in angioma serpiginosum, the pentalogy of Cantrell and Limb-Body Wall Complex. Here we present a review of the published mutations in the PORCN gene to date and report on seven new mutations together with the corresponding clinical data. Read More

Eur J Hum Genet 2009 Jul 1;17(7):881-2; author reply 882. Epub 2009 Apr 1.

Hautarzt 2009 May;60(5):428-32

Universitätsklinik für Dermatologie und Allergologie, Maienweg 12, 89081, Ulm, Deutschland.

A 44-year-old woman developed punctate erythematous maculae on the backs of her hands, arms and shoulders following a pregnancy. Laboratory evaluation was unremarkable. Our differential diagnosis includes idiopathic teleangiectases, teleangiectasia eruptiva perstans, angioma serpiginosum and angiokeratoma corporis diffusum Fabry. Read More

J Drugs Dermatol 2008 Sep;7(9):882-3

Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran.

Angioma serpiginosum is a rare benign vascular disorder usually beginning in childhood. It is characterized clinically by multiple minute, bright red to purple, grouped macules and histopathologically by an ectatic dilatation of capillaries. Angiokeratoma of the vulva is an uncommon lesion occurring in older women. Read More

Clin Exp Dermatol 2009 Jul 10;34(5):e186-8. Epub 2008 Dec 10.

Laser Division, Dermatology Centre, Salford Royal Hospitals Foundation Trust, Salford, Manchester, UK.

Angioma serpiginosum (AS) is a rare, benign, vascular disorder comprising nonblanchable punctate red to purple lesions in a gyrate or serpiginous configuration. Tunable pulsed-dye laser (PDL) therapy has been successfully used in the treatment of AS. We report our results of treatment of 12 AS sites in eight patients who were treated with PDL. Read More

Eur J Dermatol 2008 Nov-Dec;18(6):708-9. Epub 2008 Oct 27.

Dept of Dermatology, Kocaeli Universitesi Dermatoloji AD Umuttepe, 41080 Kocaeli, Turkey.

Angioma serpiginosum, which is characterized by multiple, minute, angiomatous puncta, is mainly located on the lower extremities of girls under the age of 16. Although any region of the body may be involved, lesions located on the palms and soles have never been reported. The lesions occur in groups, forming serpiginous patterns and rarely follow Blaschko's lines. Read More

J Cutan Med Surg 2008 Jul-Aug;12(4):180-3

Division of Dermatology, University of Alberta, Edmonton, AB.

Background: Angioma serpiginosum is a vascular anomaly that classically presents in childhood and predominantly affects females.

Objective: To present a case of a young woman with linear distribution of angioma serpiginosum and review the common clinical characteristics and presentation of this condition.

Methods: Case report with skin biopsies and dermoscopic findings. Read More

Yonsei Med J 2008 Jun;49(3):509-13

Department of Dermatology, Taipei Municipal Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan.

Angioma serpiginosum is an uncommon, acquired vascular nevoid disorder with capillary dilation and proliferation in the papillary dermis. The eruptions are asymptomatic and characterized by grouped, erythematous to violaceous, serpiginous and punctate macules. The condition usually appears in females during adolescence on unilateral lower extremities and the buttocks. Read More

Eur J Hum Genet 2008 Sep 14;16(9):1027-8. Epub 2008 May 14.

Eur J Hum Genet 2007 May 7;15(5):543-7. Epub 2007 Mar 7.

Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.

We report on a four-generation family with localized subepidermal telangiectasias following Blaschko's lines (angioma serpiginosum). The vascular streaks are present at birth and progress slowly thereafter. In several family members papillomatosis of the entire oesophagus was found to be part of the condition. Read More

Am J Clin Dermatol 2006 ;7(6):383-6

Kirikkale University Faculty of Medicine, Kirikkale, Turkey.

Angioma serpiginosum is a disorder of dilated superficial dermal capillaries. The disease is considered by some authors to be a consequence of increasing levels of estrogens. We present a case of angioma serpiginosum in a 46-year-old White woman. Read More

Dermatology 2006 ;213(3):256-8

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Dermatology 2006 ;213(3):236-8

Department of Dermatology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan.

In a 15-year-old Taiwanese girl, multiple purple punctate lesions arranged in a systematized, segmental pattern had developed since childhood, beginning from the right thigh and gradually progressing upwards to the right buttock, the left side of the abdomen, circumventing to the left side of the back, and extending to the right arm as well as to the posterolateral aspect of the left leg. Histopathological examination showed dilated capillaries in the uppermost part of the dermal papillae characteristic of angioma serpiginosum. The systematized, segmental and asymmetric arrangement of lesions as noted in the present case suggest that angioma serpiginosum reflects genetic mosaicism. Read More

J Dtsch Dermatol Ges 2006 Aug;4(8):650-3

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Mannheim, Ruprecht-Karls-Universität Heidelberg, Mannheim.

Angioma serpiginosum, first described by Hutchinson in 1889, is a rare benign vascular nevus with dilatation and proliferation of the capillaries in the upper dermis. A 15-year-old boy presented with an angioma serpiginosum on the right side of the body following the lines of Blaschko. Both the clinical pattern and the appearance in a male are unusual. Read More

J Dermatol 2006 Apr;33(4):252-5

Department of Dermatology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.

Angioma serpiginosum is a rare benign vascular disorder, characterized clinically by multiple minute, red to purple, grouped macules in serpiginous and gyrate patterns and histopathologically by ectatic dilatation of capillaries. Patients can undergo unnecessary hematological tests, because the condition can be confused with chronic purpuric dermatoses. An 18-year-old man with angioma serpiginosum of his left arm was evaluated by dermoscopy and treated with pulsed dye laser. Read More

J Eur Acad Dermatol Venereol 2005 Jan;19(1):127-8

Department of Dermatology, Venereology, Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Angioma serpiginosum (AS) is a rare vascular naevoid disorder due to ectatic dilation of capillaries in the papillary dermis. The condition is found almost exclusively in females who have grouped erythematous punctate lesions usually on the lower limbs or buttocks. We report two rare cases of AS, each representing a different and unusual clinical feature of AS: one with familial involvement and the other with an extensive distribution of lesions. Read More

Int J Dermatol 2004 Dec;43(12):917-8

Department of Dermatology and Pathology, BP Koirala Institute of Health Sciences, Dharan, Nepal.

J Eur Acad Dermatol Venereol 2004 Mar;18(2):238-9

Dermatol Online J 2003 Aug;9(3):19

Dermatology Department, Shiraz University of Medical Sciences, Iran. namazi_mr@ yahoo.com

Angioma serpiginosum is characterized by minute, coppery to bright-red, angiomatous puncta affecting mainly girls under age 16. The eruption predominates on the lower extremities. It is usually slowly progressive and chronic. Read More

Pediatr Dermatol 2003 Mar-Apr;20(2):167-8

Dermatology Unit, Department of Medicine, King Faisal Hospital, Taif, Saudi Arabia.

Angioma serpiginosum distributed in a linear fashion along the upper extremity of an adolescent boy is described. Histopathologic examination revealed the characteristic numerous thick-walled capillaries in the dermal papillae. Read More

J Am Acad Dermatol 2000 Feb;42(2 Pt 2):384-5

Department of Dermatology, Northwestern University Medical School, Children's Memorial Hospital Division of Dermatology, Chicago, Ill., USA.

Angioma serpiginosum is a rare condition that involves both the proliferation and dilatation of superficial blood vessels in the skin. It classically begins in childhood, is more common in females, and is asymptomatic. Typical lesions appear on the extremities and are often asymmetric. Read More

Arch Dermatol 1999 Nov;135(11):1366-8

Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.

Background: Angioma serpiginosum is a rare, acquired vascular lesion simulating purpura, and should be differentiated from purpuric dermatoses such as Henoch-Schonlein purpura.

Observations: We report 2 cases of angioma serpiginosum examined using epiluminescence microscopy. Characteristic findings of angiomas ("red lagoons") were observed entirely or focally in these 2 cases, but not in 4 cases of Henoch-Schonlein purpura and a case of senile purpura. Read More

Br J Dermatol 1997 Apr;136(4):631-2

Department of Dermatology, Bridgend General Hospital, Mid Glamorgan, U.K.

Angioma serpiginosum (AS) is a rare vascular naevoid disorder due to ectatic dilation of capillaries in the papillary dermis. The condition is found almost exclusively in females who have grouped erythematous punctate lesions usually on the lower limbs or buttocks, which may be unsightly. We report five patients with AS treated using a Candela SPLT1 pulsed tunable dye laser. Read More

Hautarzt 1995 Dec;46(12):847-9

Dermatologische Universitätsklinik, Bern.

We present a 34-year-old woman with angioma serpiginosum on the medial aspect of the left thigh, extending to the groin and the lower abdomen, and on the volar aspect of the left forearm. In addition to the late onset, the distribution along the lines of Blaschko was a remarkable feature of this case. We therefore reexamined our recent cases of angioma serpiginosum. Read More

Postgrad Med J 1991 Dec;67(794):1065-6

Department of Dermatology, Cumberland Infirmary, Carlisle, UK.

We describe two patients with angioma serpiginosum who had both undergone a variety of haematological tests for investigation of purpura, but in whom careful examination of the skin demonstrated abnormal blood vessels rather than extravasated blood. Recognition of vascular disorders which simulate purpura may avoid unnecessary investigations. Read More

Pediatriia 1991 (6):90-2