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Clin Case Rep 2022 May 12;10(5):e05850. Epub 2022 May 12.

Departement of General Surgery Internal Security Forces Hospital Marsa Tunisia.

Primary retroperitoneal cavernous hemangioma is an extremely rare disease in clinical practice. It is classified as a vascular tumor. Only three cases have been reported in the literature. Read More

Eur J Cardiothorac Surg 2022 May 19. Epub 2022 May 19.

Department of Cardiac Surgery, Wuhan Asia Heart Hospital, Wuhan, P.R. China.

Front Pediatr 2022 2;10:849496. Epub 2022 May 2.

Department of Dermatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Background And Purpose: This study was conducted to explore the plasma drug concentration of propranolol in Chinese Han patients with infantile haemangioma (IH) and the influencing factors, as well as the relationship among plasma drug concentrations of propranolol, β1-AR mutation and CYP2D6 188C>T, efficacy, and safety.

Experimental Approach: From January 2018 to April 2019, 140 patients with IH who were admitted to the hospital for oral propranolol and agreed to have their plasma concentration of propranolol tested, including 112 patients with β1-AR and CYP2D6 gene tested.

Key Results And Conclusions And Implications: The mean peak blood levels of propranolol, 4-hydroxypropranolol (4-OH-P), and N-deisopropylpropranolol (NDP) were 60. Read More

Front Oncol 2022 2;12:892943. Epub 2022 May 2.

Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.

Extraskeletal osteosarcoma is a rare malignant soft-tissue sarcoma that is difficult to diagnose. Surgery is a common treatment, although chemotherapy and radiotherapy are also used. Patients at risk of bleeding can undergo embolization combined with resection. Read More

J Interv Med 2022 Feb 26;5(1):6-9. Epub 2022 Feb 26.

Department of Radiology, Tianjin Third Central Hospital, Tianjin, 300170, China.

Hepatic hemangiomas (HHs) are the most common benign tumors of the liver. These tumors are mainly asymptomatic and do not require treatment. Nevertheless, there are some special cases that require therapeutic intervention, and surgery and intervention are currently the primary treatment modalities. Read More

J Vet Med Sci 2022 May 19. Epub 2022 May 19.

Laboratory of Veterinary Pathology, Joint Graduate School of Veterinary Sciences, Gifu University.

Peroxiredoxin (PRDX) is an antioxidant enzyme family with six isoforms (PRDX1-6). The main function of PRDXs is to decrease cellular oxidative stress by reducing reactive oxygen species, such as hydrogen peroxide, to HO. Recently, it has been reported that PRDXs are overexpressed in various malignant tumors in humans, and are involved in the development, proliferation, and metastasis of tumors. Read More

J Belg Soc Radiol 2022 25;106(1):17. Epub 2022 Apr 25.

Ibn Sina Teaching hospital, MA.

Although frequent, the coexistence of diffuse hepatic hemangiomatosis (DHH) with giant cavernous hemangioma (GCH) should be mentioned clearly and communicated to the referring physician for an appropriate management. Read More

Dermatol Surg 2022 May 17. Epub 2022 May 17.

Department of Plastic and Reconstructive Surgery, Yokohama City University Hospital, Yokohama, Japan.

Background: Infantile hemangioma (IH) often causes cosmetic disfigurement. Early intervention with propranolol for large, high-risk lesions is recommended in the American Academy of Pediatrics' Clinical Practice Guideline. Conversely, strategies for the management of small, low-risk lesions have not been established; however, pulsed dye laser (PDL) is often used to treat these lesions. Read More

Radiology 2022 May 17:212302. Epub 2022 May 17.

Department of Radiology, Pardis Noor Medical Imaging Center, Tehran, Iran.

Curr Pharm Des 2022 May 16. Epub 2022 May 16.

Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.

Background: As a member of long non-coding RNAs (lncRNAs), maternally expressed gene 8 (MEG8) has been found involving in the progression of a variety of cancers and playing a regulatory role. Therefore, MEG8 may turn into a new therapeutic target for cancer in the future. The purpose of this review is to illustrate the molecular mechanism and physiological function of MEG8 in various cancers. Read More

Pediatr Dermatol 2022 May 16. Epub 2022 May 16.

Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Oral propranolol is recommended as the first-line agent for infantile hemangioma requiring systemic treatment. Life-threatening complications such as obstructive infantile hemangioma of the airway or infantile hepatic hemangioma associated with high-output congestive heart failure are major indications for the consideration of early treatment. We present the case of an infant with life-threatening diffuse neonatal hemangiomatosis, including airway obstruction due to subglottic hemangioma, heart failure due to multiple hepatic hemangiomas with portohepatic venous shunts, and severe anemia due to continuous gastrointestinal bleeding, in which treatment with intravenous propranolol proved successful. Read More

Womens Health (Lond) 2022 Jan-Dec;18:17455057221099018

Department of Neurology, Louis Pasteur University Hospital, Kosice, Slovakia.

Vertebral haemangioma is a benign vascular tumour mostly seen in the thoracic region of the spine. Spinal haemangiomas are usually asymptomatic and are discovered incidentally. In a few patients, however, aggressive vertebral haemangiomas can cause local pain, radicular pain or neurologic deficits, which result from neural compression. Read More

Front Surg 2022 27;9:868187. Epub 2022 Apr 27.

Gillies McIndoe Research Institute, Wellington, New Zealand.

Cells exhibiting embryonic stem cell (ESC) characteristics have been demonstrated in vascular anomalies (VAs), cancer, and fibroproliferative conditions, which are commonly managed by plastic surgeons and remain largely unsolved. The efficacy of the mTOR inhibitor sirolimus, and targeted therapies that block the Ras/BRAF/MEK/ERK1/2 and PI3KCA/AKT/mTOR pathways in many types of cancer and VAs, further supports the critical role of ESC-like cells in the pathogenesis of these conditions. ESC-like cells in VAs, cancer, and fibroproliferative conditions express components of the renin-angiotensin system (RAS) - a homeostatic endocrine signaling cascade that regulates cells with ESC characteristics. Read More

Front Oncol 2022 27;12:650797. Epub 2022 Apr 27.

Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Objectives: To investigate the feasibility of computer-aided discriminative diagnosis among hepatocellular carcinoma (HCC), hepatic metastasis, hepatic hemangioma, hepatic cysts, hepatic adenoma, and hepatic focal nodular hyperplasia, based on radiomics analysis of unenhanced CT images.

Methods: 452 patients with 77 with HCC, 104 with hepatic metastases, 126 with hepatic hemangioma, 99 with hepatic cysts, 24 with FNH, 22 with HA, who underwent CT examination from 2016 to 2018, were included. Radcloud Platform was used to extract radiomics features from manual delineation on unenhanced CT images. Read More

Hand Surg Rehabil 2022 May 12. Epub 2022 May 12.

Department of Orthopedics and Traumatology, Cliniques Universitaires de Bruxelles, Hôpital Erasme, Université libre de Bruxelles, 808 Lennik str., 1070 Bruxelles, Belgium.

Pediatric cases of post-traumatic hemangioma of the palm are rare. Clinical evaluation and imaging are sometimes ambiguous and surgical exploration may show more conclusive results. This case report discusses the diagnosis and treatment of a teenager with post-traumatic hemangioma infiltrating the flexor digitorum profundus tendon of the index finger. Read More

Int J Environ Res Public Health 2022 May 5;19(9). Epub 2022 May 5.

Shaanxi Key Laboratory of Ultrasound, School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062, China.

The development of appropriate photothermal detection of skin diseases to meet complex clinical demands is an urgent challenge for the prevention and therapy of skin cancer. An extensive body of literature has ignored all high-order harmonics above the second order and their influences on low-order harmonics. In this paper, a new iterative numerical method is developed for solving the nonlinear thermal diffusion equation to improve nonlinear photothermal detection for the noninvasive assessment of the thickness of port-wine stain (PWS). Read More

Int J Mol Sci 2022 May 5;23(9). Epub 2022 May 5.

BRIC, UMR 1312, Inserm, University Bordeaux, F-33076 Bordeaux, France.

Infantile hemangioma (IH) is the most common infantile tumor, affecting 5-10% of newborns. Propranolol, a nonselective β-adrenergic receptor (ADRB) antagonist, is currently the first-line treatment for severe IH; however, both its mechanism of action and its main cellular target remain poorly understood. Since betablockers can antagonize the effect of natural ADRB agonists, we postulated that the catecholamine produced in situ in IH may have a role in the propranolol response. Read More

Int J Mol Sci 2022 Apr 30;23(9). Epub 2022 Apr 30.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Cerebral cavernous malformation (CCM) is a cerebromicrovascular disease that affects up to 0.5% of the population. Vessel dilation, decreased endothelial cell-cell contact, and loss of junctional complexes lead to loss of brain endothelial barrier integrity and hemorrhagic lesion formation. Read More

J Dermatol 2022 May 13. Epub 2022 May 13.

Department of Dermatology, Japanese Red Cross Saitama Hospital, Saitama, Japan.

J Gastrointest Oncol 2022 Apr;13(2):787-791

Department of Interventional Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

Background: Computed tomography (CT) is a common imaging technique for diagnosis of liver tumors. However, the intensity similarity on non-contrast CT images is small, making it difficult for radiologists to visually identify hepatic cavernous hemangioma (HCH) and hepatocellular carcinoma (HCC). Recently, convolutional neural networks (CNN) have been widely used in the study of medical image classification because more discriminative image features can be extracted than the human eye. Read More

J AAPOS 2022 May 9. Epub 2022 May 9.

Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Canada; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada. Electronic address:

Purpose: To highlight prevalence, spectrum of anomalies, and outcome of ophthalmic involvement in PHACES syndrome (posterior fossa malformations, infantile hemangiomas, arterial, cardiac, eye, and sternal anomalies).

Methods: A retrospective, noncomparative, single-institution observational case series of children with PHACES was conducted from 2000 to 2019. Data on ocular presentations, interventions and visual outcomes were collected. Read More

Front Med (Lausanne) 2022 25;9:872824. Epub 2022 Apr 25.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Background: Surgery is the mainstay treatment for patients with symptomatic intramedullary spinal cavernous hemangioma (ISCH), however the time of surgical intervention remains controversial. In this study, we proposed emergency rescue surgery (ERS) for patients in deteriorative type. The prognostic factors of patients with ISCH after microsurgery and the clinical effect of ERS were analyzed. Read More

Magn Reson Med Sci 2022 May 11. Epub 2022 May 11.

Department of Radiology, Faculty of Medicine, Kyorin University.

Purpose: To assess the effect of an ultrahigh b value of 3000 s/mm and the minimal TE of 53 ms on image quality and T2 shine-through effect in liver diffusion-weighted imaging (DWI) using a 3-Tesla MRI scanner with a peak gradient of 100 mT/m.

Methods: At b values of 1000 and 3000 s/mm and at the minimal (44-53 ms) and routine TEs (70 ms), DWI of our original phantom and liver DWI in 10 healthy volunteers and 26 patients with 35 hepatic hemangiomas were acquired with this scanner, and the quantified SNR of the phantom and the hepatic parenchyma in the volunteers and the contrast-to-noise ratio (CNR) of the hepatic hemangiomas were calculated; two independent readers qualitatively graded the overall image quality in the volunteers and determined the presence or absence of the T2 shine-through effect related to the hemangiomas in the patients. We compared the SNR and subjective overall image quality between the minimal and routine TEs and the CNR and incidence of the T2 shine-through effect between b values of 1000 and 3000 s/mm. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Mar;47(3):390-395

Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, China.

Pseudomyogenic hemangioendothelioma (PHE) is a rare angiogenic tumor. Histologically, the morphological characteristics of neoplastic vessels and endothelial differentiation are not obvious, and it is easy to be confused with epithelioid sarcoma, epithelioid hemangioendothelioma and myogenic tumor. PHE usually occurs in arms and legs in young people and has a significant male predominance. Read More

Abdom Radiol (NY) 2022 May 10. Epub 2022 May 10.

Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, 1053 Carling Avenue, C1 Radiology, Ottawa, ON, K1Y 4E9, Canada.

Objective: To compare diagnostic accuracy of washout (WO)-CT to chemical shift (CS)-MRI + T2W adrenal MRI Calculator (T2W-Calculator) to diagnose adrenal adenoma in indeterminate adrenal masses.

Methods: This retrospective, cross-sectional, non-inferiority study evaluated 40 consecutive indeterminate adrenal masses; each with WO-CT and MRI. Two blinded radiologists independently evaluated in mixed order: pre-contrast attenuation (Hounsfield Units, HU) and absolute WO ([Peak. Read More

J Ultrasound Med 2022 May 10. Epub 2022 May 10.

Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Santiago, Chile.

The advances in dermatologic ultrasound have been significantly influenced by the development of high- and ultrahigh-frequency probes, the provision of guidelines for performing the examinations, and a growing number of publications in the field. This review analyzes the most significant contributions that have impacted the daily practice of dermatologists in recent years. This includes the advances in anatomical detection and the patterns of benign and malignant cutaneous tumors, inflammatory dermatologic conditions, vascular anomalies, nail abnormalities, and aesthetic procedures. Read More

J Neurosurg 2022 Apr 29:1-9. Epub 2022 Apr 29.

Objective: Giant cerebral cavernous malformations (GCCMs) are rare vascular malformations. Unlike for tumors and aneurysms, there is no clear definition of a "giant" cavernous malformation (CM). As a result of variable definitions, working descriptions and outcome data of patients with GCCM are unclear. Read More

Neurosurg Focus 2022 05;52(5):E4

1Department of Neurosurgery, University Hospital of Basel.

Objective: Sturge-Weber syndrome (SWS) is a rare neurocutaneous disorder presenting mostly with a facial port-wine stain and leptomeningeal angiomatosis. More than 85% of the patients are affected by epilepsy by the age of 2 years. Seizure and symptom control is the focus of SWS treatment, since no causal therapy exists yet. Read More

Neurol India 2022 Mar-Apr;70(2):822-823

Departments of Neurological Surgery, Juntendo University Urayasu Hospital, Urayasu, Chiba.