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    Angiolymphoid hyperplasia of external ear treated with intralesional radiofrequency ablation.
    BMJ Case Rep 2018 Apr 20;2018. Epub 2018 Apr 20.
    All India Institute of Medical Sciences, Department of Dermatology and Venereology, New Delhi, India.
    A 21-year-old woman presented with multiple erythematous to skin-coloured dome-shaped firm papules and plaques over the right ear concha and external auditory canal for 1 year. It was associated with occasional itching and bleeding. Her main concern was cosmetic disfigurement. Read More
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    Giant Renal Hemangioma in an Adolescent Girl: A Very Rare Entity.
    Urology 2018 Apr 17. Epub 2018 Apr 17.
    Istanbul University, Istanbul Faculty of Medicine, Dept of Urology, Division of Pediatric Urology,. Electronic address:
    Hemangiomas are benign vascular tumors of childhood and they usually tend to be located in the upper parts of the body (head and neck). However, renal hemangiomas are very rare and usually occur to be small (1-2 cm) in size. Here, we report an adolescent girl with a giant renal hemangioma of 15 cm diameter. Read More
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    Mesenteric infantile hemangioma: diagnostic work-up.
    Quant Imaging Med Surg 2018 Mar;8(2):252-256
    Radiology Department, Santobono Hospital, Napoli, Italy.
    A very rare localization of infantile hemangioma (IH) is mesentery. It may manifest with intra-luminal or intra-peritoneal bleeding. Here there is the case of a 45-day-old infant, presenting with anemia and poor growth, subsequently referred to an uncommon hemangioma of the mesentery. Read More
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    Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations.
    Front Physiol 2018 5;9:334. Epub 2018 Apr 5.
    Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China.
    The formation of hepatic hemangiomas (HH) is associated with VEGF and IL-7 that alter conduit arteries and small arterioles. To our knowledge, there are no studies to investigate the effects of HH on the hemodynamics in conduit arteries. The aim of the study is to perform morphometric and hemodynamic analysis in abdominal conduit arteries and bifurcations of HH patients and controls. Read More
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    Medical, Surgical, and Wound Care Management of Ulcerated Infantile Hemangiomas: A Systematic Review.
    J Cutan Med Surg 2018 Apr 1:1203475418770570. Epub 2018 Apr 1.
    5 Division of Dermatology, Women's College Hospital, University of Toronto, Toronto, ON, Canada.
    Ulcerated infantile hemangiomas may present a therapeutic challenge, especially if there is concurrent hemorrhage or infection. The aim of this study was to systematically review the published evidence on the treatment of ulcerated hemangiomas, focusing on wound healing as the outcome of interest. We searched MEDLINE, Embase, SCOPUS, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science from inception to July 2016. Read More
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    Synovial Haemangioma of the Elbow: A rare paediatric case and imaging dilemma.
    Sultan Qaboos Univ Med J 2018 Feb 4;18(1):e93-e96. Epub 2018 Apr 4.
    Department of Orthopaedics & Traumatology, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.
    Synovial haemangiomas are rare benign vascular proliferations arising in synovium-lined surfaces. While the knee is by far the joint most commonly involved, this condition can also occur in the elbow. We report an eight-year-old boy who presented to the National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia, in 2016 with a left elbow swelling of one year's duration. Read More
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    PEDF/VEGF ratio plays a crucial role in the spontaneous regression of infant hemangioma and the therapeutic effect of propranolol.
    Cancer Sci 2018 Apr 17. Epub 2018 Apr 17.
    Program of Molecular Medicine Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine Sun Yat-sen University, Guangzhou, 510080, China.
    Infantile hemangioma (IH) is a benign tumor that is formed by aberrant angiogenesis and that undergoes spontaneous regression over time. Propranolol, the first-line therapy for IH, inhibits angiogenesis by downregulating the activation of the VEGF pathway, which is hyperactivated in IH. However, this treatment is reportedly ineffective for 10% of tumors, and 19% of patients relapse after propranolol treatment. Read More
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    Detailed Imaging Findings in a Rare Case of Kimura Disease, with Special Mention on Diffusion Weighted Imaging.
    Pol J Radiol 2017 20;82:607-611. Epub 2017 Oct 20.
    Department of Radiodiagnosis, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Poona, Maharashtra, India.
    Background: Kimura disease is an uncommon, benign, chronic, idiopathic disease that is seen mainly in the Asian population, particularly in females. It mainly affects the salivary glands and in particular parotid and cervical lymph nodes. So far, the diagnosis of Kimura disease has been based on histopathology. Read More
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    Oncosuppressors and Oncogenes: Role in Haemangioma Genesis and Potential for Therapeutic Targeting.
    Int J Mol Sci 2018 Apr 13;19(4). Epub 2018 Apr 13.
    Department of Physiology, Faculty of Health Sciences, University of Pretoria, 9 Botshelo Road, Pretoria 0007, South Africa.
    Genetic lesions in proto-oncogenes result in the perturbation of angiogenesis, the formation of neovessels from a pre-existing microvasculature. Similarly, the subversion of tumor suppressor genes promotes tumor vascularization. Excessive neovessel formation is associated with various neoplasms such as infantile hemangiomas (IH). Read More
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    The Effect of Oral Propranolol versus Oral Corticosteroids in Management of Pediatric Hemangiomas.
    World J Plast Surg 2018 Jan;7(1):16-24
    Sir Syed Nagar, JNMCH, AMU, Aligarh, India.
    Background: Hemangiomas are the most common benign tumors of infancy. This study evaluated the efficacy of oral propranolol comparing to oral steroids in management of pediatric hemangiomas.

    Methods: In North India from January 2012 to January 2015, sixty children <6 years old with superficial hemangiomas were divided into 2 groups; oral propranolol vs. Read More
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    Endoscopic transseptal approach with a bilateral nasoseptal flap in challenging skull-base tumors.
    World Neurosurg 2018 Apr 9. Epub 2018 Apr 9.
    Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address:
    Objective: To examine the utility of an endoscopic transseptal approach and the creation of a bilateral nasoseptal flap using a two-nostrils/four-hands technique in patients with challenging skull-base tumors.

    Methods: The medical records of patients operated on via an endoscopic transseptal approach between 2009 and 2017 were retrospectively reviewed. Two patients with ossifying fibroma, two with orbital hemangioma, two with trigeminal nerve schwannoma, and one patient each with juvenile angiofibroma, meningioma, and myxofibrosarcoma were included in the study. Read More
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    Atypical Hemangioma Mimicking Metastasis on 18F-Sodium Fluoride Positron Emission Tomography-Computed Tomography and Magnetic Resonance Imaging: Gallium-68-Prostate-Specific Membrane Antigen Positron Emission Tomography Improves the Specificity of Bone Lesions.
    Indian J Nucl Med 2018 Apr-Jun;33(2):171-173
    Department of Radiology, Jack Brignall PET/CT Centre, Castle Hill Hosptial, Cottingham, England.
    Vertebral hemangioma is a benign condition, but sometimes, it might represent as diagnostic dilemma especially in elderly patient mimicking serious pathology like metastasis. We report a case of a 66-year-old man with prostate cancer. 18F-sodium fluoride positron emission tomography-computed tomography (F-NaF PET-CT) demonstrates increased radiotracer uptake at body of D4 vertebra. Read More
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    The poor prognosis of the primary gastric epithelioid angiosarcoma: A case report.
    Medicine (Baltimore) 2018 Apr;97(15):e0287
    Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
    Rationale: Primary gastric epithelioid angiosarcoma is a highly aggressive endothelial cell malignancy and may pose a great diagnostic challenge.

    Patient Concerns: Here we describe the case of a 56-year-old man presented with melena and epigastric dull pain for 2 weeks.

    Diagnosis: Primary gastric epithelioid angiosarcomas: the definitive diagnosis was provided by immunohistochemical analysis with endothelial markers such as cluster of differentiation 31 (CD31), ether-a-go-go-related gene (ERG), and Freund leukemia integration (FLI-1). Read More
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    Capillary hemangioma associated with dermal atrophy masquerading as a deep fungal infection.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.
    Hemangiomas are benign vascular neoplasms which arise in early adulthood. Herein we present a 79-year-old woman with a hemangioma of the lower flank masquerading as a cutaneous manifestation of a systemic fungal infection upon initial histological analysis. Decreased elastin and collagen within the lesion likely accounted for the clumping and splaying of the capillaries into "hyphae-like" structures. Read More
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    Safety and efficacy of single-fraction gamma knife radiosurgery for benign confined cavernous sinus tumors: our experience and literature review.
    Neurosurg Rev 2018 Apr 9. Epub 2018 Apr 9.
    Department of Medical Physics, Panjab University, Chandigarh, 160012, India.
    Gamma knife radiosurgery (GKRS) has emerged as a suitable primary treatment option for confined cavernous sinus tumors (CSTs) and residual/recurrent benign tumors extending from the surrounding neighborhood. The aim of this review was to further investigate the safety and efficacy of single-fraction GKRS for primary confined CSTs (hemangioma, meningioma, and schwannoma). This was a retrospective analysis of 16 patients of CSTs, primarily treated with GKRS between 2009 and 2017. Read More
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    Malignant tumors misdiagnosed as benign vascular anomalies.
    Pediatr Blood Cancer 2018 Apr 6:e27051. Epub 2018 Apr 6.
    Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.
    Background: Malignant soft tissue tumors are rare and difficult to diagnose in children. These can initially be misdiagnosed as benign vascular anomalies. Management of these two conditions differs drastically and delay in diagnosis may impact overall survival. Read More
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    The Houdini Tumor: A Case Report and Literature Review of Pregnancy Associated Meningiomas.
    World Neurosurg 2018 Apr 4. Epub 2018 Apr 4.
    Department of Radiology, LLUMC, CA, United States.
    Background: Meningiomas are common intracranial neoplasms of undetermined etiology. Accelerated growth during episodes of elevated serum estrogen and progesterone have been demonstrated in pregnant patients, as exhibited by an overexpression of estrogen or progesterone upon immunohistochemical analysis. This case report and literature review describes a case of complete meningioma regression in a postpartum patient. Read More
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    Choroidal and Sub-Retinal Pigment Epithelium Caverns: Multimodal Imaging and Correspondence with Friedman Lipid Globules.
    Ophthalmology 2018 Apr 3. Epub 2018 Apr 3.
    Vitreous Retina Macula Consultants of New York, New York, New York. Electronic address:
    Purpose: To survey Friedman lipid globules by high-resolution histologic examination and to compare with multimodal imaging of hyporeflective caverns in eyes with geographic atrophy (GA) secondary to age-related macular (AMD) and other retinal diseases.

    Design: Histologic survey of donor eyes with and without AMD. Clinical case series with multimodal imaging analysis. Read More
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    Multidisciplinary management of an intra-sellar cavernous hemangioma: Case report and review of the literature.
    J Clin Neurosci 2018 Apr 2. Epub 2018 Apr 2.
    Radiotherapy Department, Paul Strauss Centre, Strasbourg, France.
    Extra-axial cavernous hemangiomas (ECH) are rare vascular lesions with a tendency to grow within the medial structures of the middle cranial fossa. This pathological entity lacks specific symptoms, and falls into the category of differential diagnosis of space occupying lesions in the cavernous sinus (CS) with or without sellar involvement, including those of tumoral, vascular and inflammatory nature. Of note, ECH can also be indolent, and is at times discovered incidentally during autopsy investigations. Read More
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    Imaging of Pediatric Salivary Glands.
    Neuroimaging Clin N Am 2018 May 7;28(2):209-226. Epub 2018 Mar 7.
    Department of Medical Imaging, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724, USA.
    Salivary gland diseases in children are uncommon, and the relative incidence of pathologies is different than in adults. This article presents a comprehensive review of congenital and acquired disorders that affect the major salivary glands in the pediatric population, highlighting the imaging findings that are important in defining the appropriate diagnosis or narrowing of the differential diagnosis. Read More
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    Treatment of Facial Infantile Hemangioma: Comparative Study Between Propranolol and Ethanolamine Oleate.
    J Craniofac Surg 2018 Apr 4. Epub 2018 Apr 4.
    Institute of Plastic and Craniofacial Surgery, SOBRAPAR Hospital, Campinas, Brazil.
    Background: Infantile hemangiomas (IH) are the most common benign vascular tumors in childhood. Approximately 10% to 15% of these tumors require drug or surgical intervention. There are many options for IH treatment, of which propranolol is currently considered the gold standard. Read More
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    Primary racemose hemangioma with bronchial-pulmonary arterial fistula.
    Respirol Case Rep 2018 Jul 1;6(5):e00314. Epub 2018 Apr 1.
    Department of Thoracic and Cardiovascular SurgeryMie University School of MedicineMieJapan.
    Primary racemose hemangioma with bronchial-pulmonary arterial fistula is a very rare abnormality. We herein report an asymptomatic case of primary racemose hemangioma with no significant size change in 5 years. Read More
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    Intraosseous hemangioma of the orbit.
    Arch Craniofac Surg 2018 Mar 20;19(1):68-71. Epub 2018 Mar 20.
    Department of Pathology, Pusan National University School of Medicine, Busan, Korea.
    Intraosseous hemangioma is an extremely rare tumor that accounts for 1% or fewer of all osseous tumors. The most common sites of its occurrence are the vertebral column and calvaria. Occurrence in a facial bone is very rare. Read More
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    Cleft Palate Repair Using Single Flap Palatoplasty in Patient With Associated Palatal Hemangioma.
    J Craniofac Surg 2018 Mar 30. Epub 2018 Mar 30.
    Department of Plastic Reconstructive and Aesthetic Surgery.
    Hemangiomas are the most common tumors of childhood with an average incidence of 10%. It is unusual for hemangiomas, which are already rarely seen isolated on the palate, to coexist with cleft palate as in the authors' patient. Four months old baby was admitted with isolated Veau 2 cleft palate and a red-purple colored raised lesion involving almost the whole right side of the hard palate. Read More
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    Nonepithelial Tumors and Tumor-like Lesions of the Skin and Subcutis in Children.
    Pediatr Dev Pathol 2018 Mar-Apr;21(2):150-207
    3 Department of Pathology, University of Virginia, Charlottesville, Virginia.
    This overview of mesenchymal tumors presenting in the skin and/or subcutis in children brings together the range of neoplasms and hamartomas which are seen in this age-group. It is not surprising from the perspective of the pediatric or general surgical pathologist that vascular anomalies, including true neoplasms and vascular malformations, are the common phenotypic category. Since there is considerable morphologic overlap among these lesions, clinicopathologic correlation may be more important than for many of the other mesenchymal tumors. Read More
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    Angiolymphoid hyperplasia with eosinophilia: a case report.
    J Med Case Rep 2018 Apr 2;12(1):89. Epub 2018 Apr 2.
    Department of Pathology, Tishreen University Hospital, Tishreen University, Lattakia, Syria.
    Background: Angiolymphoid hyperplasia with eosinophilia is a benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate. Mostly, it affects middle-aged adults manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area.

    Case Presentation: In this case, we report a 13-year-old Caucasian girl with bilateral, huge, protruding, and yellowish nostril masses which were peculiar in location and of gross appearance. Read More
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    Open resection and laryngotracheal reconstruction in a case of subglottic hemangioma in PHACE syndrome.
    Int J Pediatr Otorhinolaryngol 2018 May 9;108:186-189. Epub 2018 Mar 9.
    Department of Otolaryngology, Louisiana State University Health Sciences Center and Children's Hospital New Orleans, New Orleans, LA, USA. Electronic address:
    We describe a 1 month old infant with PHACE syndrome who underwent successful management of subglottic hemangioma by open resection and laryngotracheal reconstruction using a thyroid ala graft. Propranolol is typically the treatment of choice for subglottic hemangiomas however, recent reports have suggested adverse complications with the use of propranolol in children with PHACE syndrome. The child had cerebral and cervical vascular anomalies associated with her PHACE syndrome making her at an increased risk of stroke with the use of propranolol. Read More
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    Selected presentations of lip enlargement: clinical manifestation and differentiation.
    Postepy Dermatol Alergol 2018 Feb 20;35(1):18-25. Epub 2018 Feb 20.
    Department of Oral Surgery, Poznan University of Medical Sciences, Poznan, Poland.
    Lip enlargement may be an important symptom of either systemic or local diseases. On the basis of selected age-matched clinical cases we present the possible causes of lip swelling. We describe the most representative symptoms and recommend treatment of these pathologies. Read More
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    Analysis of Follicle-Stimulating Hormone Receptor in Infantile Hemangioma.
    Ann Plast Surg 2018 Apr;80(4 Suppl 4):S211-S213
    From the Department of Plastic and Oral Surgery, Vascular Anomalies Center, Boston Children's Hospital, Harvard Medical School, Boston, MA.
    Introduction: The life cycle of infantile hemangioma (IH) and secretion of follicle-stimulating hormone (FSH) are identical. We previously have shown that IH contains the FSH receptor (FSHR). The purpose of this study was to identify which cell type(s) in IH expresses FSHR. Read More
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    Interpreting body MRI cases: classic findings in abdominal MRI.
    Abdom Radiol (NY) 2018 Mar 28. Epub 2018 Mar 28.
    Radiology, Thomas Jefferson University Hospital, 132 South 10th Street, Suite 1087, Main Building, Philadelphia, PA, 19107, USA.
    Few things in radiology are "pathognomonic" in their appearance or presentation. However, having an awareness of those findings which are specific to a certain entity is important when interpreting imaging studies. These classic findings can be identified with many imaging modalities, but no modality provides as many recognizable observations as an MRI. Read More
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    [Repurposing of betablockers in dermatology].
    Rev Med Suisse 2018 Mar;14(600):670-675
    Service de dermatologie et vénéréologie, HUG, 1211 Genève 14.
    Betablockers are used for decades in the treatment of cardiovascular diseases. Recently, the repurposing of the wide spectrum betablocker propranolol revolutionized the infantile hemangioma management. Besides, betablockers have been shown to significantly improve the prognosis of melanoma patients. Read More
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    Optical coherence tomography angiography features of choroidal hemangioma.
    Indian J Ophthalmol 2018 Apr;66(4):581-583
    Department of Vitreoretina and Ocular Oncology, Sankara Eye Hospital, Bengaluru, Karnataka, India.
    This is an observational case series of four cases of choroidal hemangioma. All cases underwent OCT angiography with swept source OCTA (Topcon DRI OCT Triton plus) 6 mm * 6 mm protocol. OCTA at the level of large choroidal vessels demonstrated peculiar vascular pattern in all four eyes. Read More
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    Three Cases of Congenital Retinal Macrovessel, One Coexisting with Cilioretinal Artery.
    Turk J Ophthalmol 2018 Feb 23;48(1):52-55. Epub 2018 Feb 23.
    Ulucanlar Eye Training and Research Hospital, Ophthalmology Clinic, Ankara, Turkey.
    In this report, we describe three cases of retinal macrovessel. Two of the three patients presented to our clinic for annual eye exam and had no visual complaints. The third patient presented because of vision loss in the left eye. Read More
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    Imaging and Pathologic findings of Hepatic Small Vessel Hemangioma.
    Curr Probl Diagn Radiol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Radiology University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address:
    Hepatic small vessel hemangioma represents a distinct yet very rare pathologic entity of the liver. The entity has also been in the past referred to as adult capillary hemangioma of the liver and congenital noninvoluting hemangioma. Imaging findings are not definitive and biopsy or resection is ultimately necessary. Read More
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    Cutaneous metastases of infantile choriocarcinoma can mimic infantile hemangioma both clinically and radiographically.
    Pediatr Radiol 2018 Mar 24. Epub 2018 Mar 24.
    Department of Medical Imaging, Phoenix Children's Hospital, Phoenix, AZ, USA.
    Infantile metastatic choriocarcinoma is a rare tumor of placental origin that can be observed with or without maternal metastases. A single cutaneous mass may be the only clinically observed sign. Reports of imaging findings are scarce given the extreme rarity of the tumor, and the disease can be rapidly fatal in the absence of prompt diagnosis. Read More
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    Safety Profile during Initiation of Propranolol for Treatment of Infantile Hemangiomas in an Ambulatory Day-Care Hospitalization Setting.
    J Eur Acad Dermatol Venereol 2018 Mar 24. Epub 2018 Mar 24.
    Pediatric Dermatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
    Background: Propranolol is the mainstay of treatment for infantile hemangioma. Despite its good safety profile, it is not risk-free. Guidelines for propranolol initiation and monitoring have been suggested, but protocols vary among practitioners. Read More
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    Massive hemorrhage: A rare complication of rapidly involuting congenital hemangioma.
    Pediatr Dermatol 2018 Mar 23. Epub 2018 Mar 23.
    Department of Dermatology, Paul Sabatier University and Toulouse University Hospital, Toulouse, France.
    Rapidly involuting congenital hemangioma is a subtype of congenital hemangioma. Ulceration and bleeding are rarely reported in rapidly involuting congenital hemangioma, with only four cases reported in the literature to our knowledge. We describe a case of a newborn girl who presented with rapidly involuting congenital hemangioma complicated by ulceration and severe bleeding and discuss treatment. Read More
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    [Benign aggressive vascular anomalies in children].
    Bull Cancer 2018 Mar 20. Epub 2018 Mar 20.
    Centre de référence des maladies rares de la peau d'origine génétique, hôpital Pellegrin-Enfants, centre hospitalier universitaire de Bordeaux, unité de dermatologie pédiatrique, 33076 Bordeaux cedex, France.
    Superficial vascular anomalies constitute a large group of malformative and tumoral conditions developed from all types of vessels. Vascular tumors are the result of cellular hyperplasia, whereas vascular malformations (VMs) are constituted of dysplastic vessels. The classification from International Society for the Study of Vascular Anomalies (ISSVA) is based on this pathogenic difference. Read More
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    Common and Uncommon Benign Pancreatic Lesions Mimicking Malignancy: Imaging Update and Review.
    Semin Ultrasound CT MR 2018 Apr 26;39(2):206-219. Epub 2017 Oct 26.
    Grupo Fleury, São Paulo, Brazil; Department of Imaging, Universidade Federal de São Paulo, São Paulo, Brazil.
    There is a broad range of inflammatory, pseudotumoral, and benign lesions that may masquerade as pancreatic malignancies, often representing a challenge to the radiologist. Unawareness of these entities can lead to inadequate differential diagnoses or misdiagnosis, with important prognostic and therapeutic consequences. The purpose of this article is to revisit a spectrum of lesions, varying from common to exceedingly rare nonmalignant, that may mimic malignant pancreatic neoplasms on imaging, identifying relevant features that may contribute to reaching the correct diagnosis. Read More
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