Search Our Scientific Publications & Authors

Case Rep Cardiol 2019 7;2019:7916298. Epub 2019 Mar 7.

Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands.

The incidence of heart valve hemangioma is very low and is mostly observed in the mitral and tricuspid valve. In 2006, two cases of aortic valve hemangioma were reported for the first time, including one with calcifying aortic valve stenosis. We now present a case of aortic valve hemangioma in a patient suffering from aortic valve insufficiency combined with atherosclerotic thickening. Read More

Oral Maxillofac Surg 2019 Apr 23. Epub 2019 Apr 23.

Department of Oral and Maxillofacial Surgery and Plastic Operations, Central Medical Centre Bremen, Bremen, Germany.

Introduction: Chronic inflammatory diseases of the skin are the most common differential diagnosis of tumorous lesions of the craniofacial region. Detailed information about a patient's medical history is important for the clinical diagnosis of such cases. Previous radiotherapy should be taken into account, especially in cases of chronic dermatitis, since complications include osteoradionecrois of the adjacent bone strucutres with surrounding inflammation. Read More

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Neurosurgery Department, Saint Joseph hospital, Beirut, Lebanon; Faculty of Medicine - Saint Joseph University, Achrafieh, Lebanon. Electronic address:

Dural presentation of a cavernous hemangioma is a rare occurrence. Classically an intraparenchymal lesion with varying symptomatology including mostly headaches, seizures, and neurologic deficits depending on its location, a few cases have been reported along the convexity of the brain, even less eroding the calvaria, with none occasioning abnormal movements as the initial presentation. This is a case of a 67-year-old male who presented to the clinic for atypical progressive choreiform movements of the right side of his body and a soft subgaleal mass. Read More

Magn Reson Imaging 2019 Apr 19. Epub 2019 Apr 19.

Wake Forest University and Baptist Health, Medical Center Boulevard, Winston-Salem, NC 27157, United States of America. Electronic address:

Hepatic complications of oral contraceptive pills and exogenous estrogens include intrahepatic canalicular cholestasis, neoplasm formation and vascular pathologies. While it remains controversial as to whether estrogen plays a role in focal nodular hyperplasia, hemangioma or hamartoma, exposure to oral contraceptive pills and estrogen has a strong association with hepatic adenomas. Four different subgroups of adenomas have been described: Inflammatory, HNF-1α-mutated, β-catenin-mutated and unclassified. Read More

Indian J Ophthalmol 2019 May;67(5):704-706

Shree Bhagwan Mahavir Vitreoretinal Services Department, Sankara Nethralaya, College Road, Nungambakkam, Tamil Nadu, India.

Circumscribed choroidal hemangioma is a benign vascular hamartoma without systemic associations. For symptomatic cases, treatment options are photodynamic therapy (PDT), transpupillary thermotherapy (TTT), intravitreal injection of anti-vascular endothelial growth factor (VEGF), or radiation therapy. CyberKnife radiosurgery is an image-guided radiation therapy that delivers radiation to lesions anywhere in the body with an accuracy of 0. Read More

Indian J Ophthalmol 2019 May;67(5):701-703

Department of Vitreo-Retina and Ocular Oncology, Sankara Eye Hospital, Bangalore, Karnataka, India.

In this series, we discuss the role of optical coherence tomography angiography (OCTA) in assessing response to treatment in intraocular vascular tumors. This is a series of two cases: Multiple retinal capillary hemangioblastoma (RCH) treated with laser photocoagulation and diffuse choroidal hemangioma (DCH) with radiotherapy. In large RCH and DCH, optical coherence tomography (OCT) showed significant reduction of subretinal and intraretinal fluid. Read More

Indian J Ophthalmol 2019 May;67(5):579-581

The New York Eye Cancer Center, New York City, New York, USA.

J Cutan Pathol 2019 Apr 21. Epub 2019 Apr 21.

Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, SP, Brazil.

Intramuscular hemangioma represents less than 1% of all hemangiomas. In the head and neck region, it occurs mostly in the masseter, temporalis and sternocleidomastoid muscles. Besides its infiltrative growth pattern and several worrisome histological features, such as increased mitotic activity, plumpness of the nuclei, intraluminal papillary projections or perineural infiltration, the lesion is benign, and complete surgical excision is the preferred treatment for such oral lesions. Read More

J Cosmet Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

Lasers are fast becoming the vogue of dermatology ranging from ablative, nonablative, fractional photothermolysis to vascular lasers. There are a range of vascular lasers including potassium titanyl phosphate (KTP 532 nm), pulsed dye laser (PDL -595 nm), diode (810 nm), and Nd:YAG (1064 nm). PDL is a laser that emits yellow light using Rhodamine dye as it is lasing medium. Read More

Breast J 2019 Apr 18. Epub 2019 Apr 18.

Department of Pathology, Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Benign vascular lesions of breast are uncommon findings on core biopsy and surgical excision has been recommended to rule out a more serious lesion. However, a recent study suggested that excision may be spared for vascular lesion without atypia. The aim of this study was to assess the follow-up outcomes in lesions yielding benign vascular lesions on core biopsy. Read More

J Midlife Health 2019 Jan-Mar;10(1):48-50

Department of Pathology, Chettinad Hospital and Research Institute, Kanchipuram, Tamil Nadu, India.

Anastomosing hemangioma (AH) is a rare vascular tumor, which has a predilection for the genitourinary system. Ovarian AH is rare, only few cases have been reported in literature so far. Here, we report a case of 50-year-old woman with right ovarian mass clinically diagnosed as ovarian epithelial malignancy. Read More

J Neurosci Rural Pract 2019 Apr-Jun;10(2):339-341

Department of Neurosurgery, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, Karnataka, India.

Cavernomas are vascular malformations which are collections of endothelium-lined sinusoids without intervening cerebral parenchyma. Hypothalamic location of cavernoma is extremely rare. We present a case of a 34-year-old male who presented with complaints of recent memory loss and vomiting. Read More

Klin Monbl Augenheilkd 2019 Apr 18. Epub 2019 Apr 18.

Benign orbital neoplasms comprise a wide spectrum of different entities. The origin of the tumours can be epithelial or mesenchymal. Epithelial neoplasms of the orbit originate from the lacrimal gland. Read More

Radiol Case Rep 2019 Jun 3;14(6):750-754. Epub 2019 Apr 3.

Department of Radiological Sciences, University of California Irvine, Orange, CA, USA.

Renal capillary hemangiomas are rare and benign vascular tumors which are typically incidentally discovered on imaging. Surgical excision is often performed, as imaging appearance is similar to malignant lesions. Renal hemangiomas are typically solitary and unilateral. Read More

Iran J Otorhinolaryngol 2019 Mar;31(103):119-122

Department of Pathology, Dokuz Eylül University School of Medicine, Izmir, Turkey.

Introduction: Sialolipoma is an extremely rare salivary gland tumor characterized by a well circumscribed mass composed of glandular tissue and mature adipose elements. Herein our aim was to present the fifth case of congenital sialolipoma, which was firstly followed up as a parotid gland hemangioma, and underline the fact that sialolipomas should be kept in mind in the differential diagnosis of congenital parotid gland masses.

Case Report: A 10-month old male presented with a left-sided huge neck mass which progressed after birth. Read More

Am J Case Rep 2019 Apr 16;20:525-530. Epub 2019 Apr 16.

Department of Diagnostic Radiology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.

BACKGROUND Intraosseous cavernous skull hemangiomas are rare benign vascular tumors that are usually found incidentally on imaging, with an asymptomatic and slow-growing course. We present a case in which the patient had a mass on her forehead for many years, which began to grow rapidly after head trauma. Imaging characteristics play a crucial role in the diagnosis and description of this disease, and in differentiating it from other more common calvarial lesions that may present with a similar clinical picture. Read More

Brain Nerve 2019 Apr;71(4):350-353

Department of Neurology, Graduate School of Medicine, Chiba University.

Skin changes, including peripheral edema, hyperpigmentation, hypertrichosis, and hemangioma are frequent and early manifestations of POEMS (polyneuropathy, organomegaly, enndocrinopathy, M-protein, and skin changes) syndrome. Hemangiomata is presumably caused by overproduction of the vascular endothelial growth factor, and hypertrichosis results from the deposition of melanin; however, the pathogenesis of the skin symptoms are poorly understood. Nevertheless, recognition of the skin changes facilitates early diagnosis and treatment. Read More

Z Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Department of Internal Medicine 1, University of Tuebingen, Tuebingen, Germany.

Purpose:  The purpose of this study was to analyze imaging findings in hepatic epithelioid hemangioendothelioma (HEHE) with a particular focus on contrast-enhanced ultrasound (CEUS).

Materials And Methods:  This retrospective multicenter study included 10 patients with histologically proven HEHE from 5 European centers. All existing ultrasound images/videos were independently analyzed by 2 experienced examiners (DEGUM level III, internal medicine) using a standardized evaluation form. Read More

Anticancer Drugs 2019 Jun;30(5):501-507

Department of Pharmacy, Fuwai Central China Cardiovascular Hospital.

Propranolol could repress infantile hemangioma cell growth and induce apoptosis. miR-125b could inhibit cell proliferation in some tumors. However, whether propranolol exerts its proliferation inhibition and apoptosis-promoting effect by regulating the expression of miR-125b needs to be further investigated. Read More

Am J Surg Pathol 2019 May;43(5):581-590

Division of Anatomic Pathology, Mayo Clinic, Rochester, MN.

Angiosarcoma is a rare malignant neoplasm of the liver. The various morphologic patterns seen with angiosarcomas of the liver have not been systematically studied and their recognition remains a major diagnostic challenge. In order to provide more comprehensive data on the morphologic patterns, angiosarcomas that had been diagnosed between 1996 and 2016 at a large medical referral center were reviewed. Read More

Int J Surg Case Rep 2019 Apr 4;58:1-5. Epub 2019 Apr 4.

Department of Gastrointestinal Surgery, Hokkaido Cancer Center, Sapporo, Japan.

Introduction: Hepatic sclerosing hemangiomas are rare tumors whose appearance on imaging is similar to that of malignant tumors. The resulting difficulties in preoperative diagnosis frequently lead to surgical resection in order to accurately identify the tumor.

Case Presentation: A 68-year-old man was diagnosed with multiple gastric carcinoid tumors (T1N1M0, pStage IIIB) after total gastrectomy with D2 lymph node dissection. Read More

Medicine (Baltimore) 2019 Apr;98(15):e15038

Diagnostic Radiology, Imaging Institute.

Rationale: Sclerosing pneumocytoma is a rare benign lung neoplasm seen in middle aged adults with a female predominance. Originally thought to be vascular in origin, this rare entity is now understood to be epithelial in nature. On imaging, sclerosing pneumocytoma manifests as a well circumscribed nodule or mass, often juxtapleural in location. Read More

Indian J Dermatol 2019 Mar-Apr;64(2):159-161

Department of Dermatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Eur J Orthop Surg Traumatol 2019 Apr 12. Epub 2019 Apr 12.

Department of Orthopedic Surgery, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.

Background: Synovial hemangioma is a benign intra-articular tumor. This condition is rare and unfamiliar soft tissue tumor to most orthopedic surgeons. Delayed diagnosis causes osteoarthritic damage and the destruction of joint structures due to infiltrating tumor growth. Read More

Ultrasound Med Biol 2019 Apr 9. Epub 2019 Apr 9.

Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. Electronic address:

The aim of the present study was to prospectively evaluate the clinical efficiency of 2-D shear wave elastography (2-D-SWE) for differentiating hepatoblastoma and hepatic hemangioma in children under 3 y of age. 2-D-SWE was performed in 109 consecutive patients with confirmed hepatic neoplasms by pathologic analysis or contrast-enhanced computed tomography plus follow-up observation, in which 71 patients were defined as the test group, and the remaining 38 patients were defined as the validation group. An elasticity value was obtained from each lesion. Read More

Endoscopy 2019 Apr 12. Epub 2019 Apr 12.

Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Foot (Edinb) 2019 Apr 6;39:76-78. Epub 2019 Apr 6.

Resident Physician, Department of Podiatric Medicine & Surgery, East Liverpool City Hospital, 425 W 5th St, East Liverpool, OH 43920, USA. Electronic address:

Capillary hemangiomas are rarely seen in the foot, especially in the deeper soft tissue compartment. If left untreated, they can give rise to benign soft-tissue tumors. A rare case of a capillary hemangioma on the right dorsal medial midfoot that, because of its location adjacent to the saphenous nerve, mimicked the signs and symptoms of a neuroma. Read More

Dermatol Ther 2019 Apr 12:e12919. Epub 2019 Apr 12.

Department of Dermatology, Division of Pediatric Dermatology, Stanford University School of Medicine, Stanford, CA.

J Dermatolog Treat 2019 Apr 11:1-6. Epub 2019 Apr 11.

a Dermatology Department , Security Forces Hospital , Dammam , Saudi Arabia.

Ulceration is the most common complication of Infantile Hemangioma (IH). We reported 2 cases of ulcerated IH treated by new cream formulation of brimonidine 0.2%-timolol 0. Read More

Hawaii J Med Public Health 2019 Apr;78(4):128-131

National Cancer Consortium, Walter Reed National Military Medical Center (WRNMMC), Bethesda, MD (WAK).

The majority of giant hepatic cavernous hemangiomas are asymptomatic and can safely be observed. However, when a lesion becomes symptomatic, affecting quality of life or cannot be distinguished from a malignancy, then operative therapy should be considered. We herein present a case of a symptomatic 12cm × 14cm × 17cm "mega" hemangioma (>10cm) of the left hepatic lobe. Read More

J Int Med Res 2019 Apr 10:300060519840898. Epub 2019 Apr 10.

1 Department of Respiratory Medicine, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Hubei, China.

Background: Pulmonary sclerosing hemangioma (PSH) is a rare tumor that usually develops in middle-aged Asian women. PSH has four histological types (hemorrhagic, sclerotic, solid, and papillary) and often grows slowly in a lower lobe of the lung. Preoperative misdiagnosis frequently occurs because of the absence of specific clinical manifestations and imaging findings. Read More

Pediatr Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background/objectives: First-line therapy for infantile hemangiomas (IH) is oral propranolol, a systemic beta-blocker with the risk of rare but serious adverse effects. Topical timolol presents an attractive off-label alternative with good tolerability, but sequential therapy with propranolol followed by timolol is not well studied. Here, we report effects of topical timolol preceding or following oral propranolol as adjunct therapy for IH. Read More

Mol Clin Oncol 2019 May 14;10(5):521-523. Epub 2019 Mar 14.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.

von Hippel Lindau (VHL) disease is caused by inactivation of the VHL tumor suppressor gene, resulting in formation of multiple systemic tumors. Juxtapapillary retinal capillary hemangioma (JRCH) is one of the major manifestations in VHL disease; however, treatments are challenging, especially in children. The present study reports the case of a 6-year-old girl with suspected VHL disease presenting with JRCH. Read More

Biomed Pharmacother 2019 Apr 6;114:108823. Epub 2019 Apr 6.

Department of Hemangioma & Vascular Malformation, The People's Hospital of Zhengzhou University, 7 Weiwu Road, Jinshui District, Zhengzhou 450003, China.

We previously developed propranolol-encapsulated liposomes-in-microspheres (PLIM) to realize the sustained propranolol release for the treatment of hemangiomas. However, the liposomes released from the microspheres still lacked specificity for CD133-positive hemangioma-derived stem cells (HemSCs) which are considered to be the seeds of hemangiomas. Therefore, we hereby encapsulated propranolol-loaded CD133 aptamers conjugated liposomes in poly(lactic-co-glycolic acid (PLGA) microspheres to develop propranolol-loaded CD133 aptamers conjugated liposomes-in-microspheres (PCLIM), to realize the aim of the sustained and targeted therapy of hemangiomas. Read More

Thorac Cancer 2019 Apr 9. Epub 2019 Apr 9.

Department of Thoracic Surgery, Gyeongsang National University School of Medicine, Jinju, South Korea.

Br J Neurosurg 2019 Apr 9:1-3. Epub 2019 Apr 9.

c Neuropathology , Mikro Lab , Alsancak, Izmir , Turkey.

Intravascular papillary endothelial hyperplasia (Masson's vegetated hemangioendothelioma) is a rare condition affecting the neuroaxis. In the literature, only eight cases of this lesion involving the vertebral canal with spinal cord compression has been reported. We present a 37-year-old man with thoracic location mimicking schwannoma. Read More

Laryngoscope 2019 Apr 8. Epub 2019 Apr 8.

Babina Diagnostics, Imphal, India.

Anastomosing hemangioma (AH) is an uncommon benign vascular neoplasm first described in the genitourinary tract. Symptomatically and histologically mimicking malignant angiosarcoma, a few rare cases have been described in the nonrenal genitourinary tract. Here, we report a 37-year-old man with a nasal AH and epistaxis. Read More

Open Access Maced J Med Sci 2019 Mar 14;7(5):794-796. Epub 2019 Mar 14.

Clinic of Dermatology, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Angiolymphoid hyperplasia with eosinophilia is an uncommon, benign, vasoproliferative cutaneous neoplasm with uncertain origin. It preferably affects middle-aged adults, manifesting as plum-colored pruritic papules, nodules and plaques, which can persist indefinitely, relapsing over time. Different response/resistance to various therapeutic modalities and frequent recurrences impose a great therapeutic dilemma. Read More

Patient Saf Surg 2019 26;13:17. Epub 2019 Mar 26.

Department of Trauma and Orthopedic Surgery A, Hassan II Teaching Hospital, Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdellah University, Atlas, Avenue Hassan II, 1835 Fès, BP 30000 Morocco.

Background: Hemangiomas are benign tumors usually found in the lower extremity yet their surgical management on the location in the foot is rarely documented.

Case Presentation: We report a case of a plantar intramuscular hemangioma in 25-year-old patient with a history of percutaneous therapy. Patient had undergone intralesional sclerotherapy 3 years prior to his admission with persistent pain on weight bearing activities. Read More

J Fr Ophtalmol 2019 Apr 5. Epub 2019 Apr 5.

Service d'ophtalmologie, université catholique de Lille, groupement des hôpitaux de l'institut catholique de Lille, 59000 Lille, France.

Ear Nose Throat J 2019 Apr 8:145561319841229. Epub 2019 Apr 8.

1 Department of Otolaryngology, Head and Neck Surgery in Centro Hospitalar do Porto, Porto, Portugal.

J AAPOS 2019 Apr 5. Epub 2019 Apr 5.

Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, Missouri. Electronic address:

A 10-year-old boy was referred for a circumscribed choroidal hemangioma with underlying exudative detachment of the left eye. To avoid general anesthetics required for laser-based therapy in a child, we began a trial of oral propranolol. The patient's exudative detachment resolved, with resulting improvement in visual acuity, and remained quiescent for 3 years. Read More

Arch Pathol Lab Med 2019 Apr 8. Epub 2019 Apr 8.

From the Department of Pathology, Medical School, University of Crete, Voutes, Heraklion, Crete, Greece.

Anastomosing hemangioma is a rare neoplastic vascular lesion, histologically mimicking angiosarcoma. It is predominantly composed of irregularly anastomosing sinusoidal-like spaces lined by endothelial cells with minimal atypia, a frequently hobnail morphology, and minimally invasive margins. Since its original description in the genitourinary system, an increasing number of anastomosing hemangiomas have been reported, localized deep in the body in various organs, always with similar histologic features. Read More

J Obstet Gynaecol India 2019 Apr 8;69(2):185-187. Epub 2018 Dec 8.

3Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bhubaneswar, 751019 India.

Cell Chem Biol 2019 Mar 14. Epub 2019 Mar 14.

Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK. Electronic address:

Vascular endothelial growth factor (VEGF) is an important mediator of endothelial cell proliferation and angiogenesis via its receptor VEGFR2. A common tumor associated with elevated VEGFR2 signaling is infantile hemangioma that is caused by a rapid proliferation of vascular endothelial cells. The current first-line treatment for infantile hemangioma is the β-adrenoceptor antagonist, propranolol, although its mechanism of action is not understood. Read More

J Pediatr 2019 Apr 4. Epub 2019 Apr 4.

Department of General Pediatrics, Tokyo Metropolitan Children's Medical Center, Fuchu, Tokyo, Japan.

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019840736

2 Hand Microsurgery Orthopaedics and Traumatology (EMOT) Hospital, Izmir, Turkey.

Purpose:: Deep palmar tumors of the hand are very rare, and reported cases are usually benign. The most important issue is frequent anatomical variations with challenging surgical exposure and excision of these lesions. Some case reports or a small series of patients have been reported in the literature. Read More