322,191 results match your criteria Angiology - The Journal of Vascular Diseases [Journal]


Comparison of 0.9-mm and 1.4-mm catheters in excimer laser coronary angioplasty for acute myocardial infarction.

Lasers Med Sci 2019 Mar 16. Epub 2019 Mar 16.

Department of Cardiovascular Medichine, Tokyo Medical and Dental Hospital, Tokyo, Japan.

Excimer laser coronary angioplasty (ELCA) is a unique revascularization modality that can vaporize plaque and thrombus. Compared to thrombus aspiration therapy, ELCA is reported to provide better microcirculation and reduced peripheral embolism in treatment for acute coronary syndrome. Excimer laser catheters come in various sizes, and we sought to compare the 0. Read More

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http://dx.doi.org/10.1007/s10103-019-02772-xDOI Listing

Activator protein-1 and caspase 8 mediate p38α MAPK-dependent cardiomyocyte apoptosis induced by palmitic acid.

Apoptosis 2019 Mar 16. Epub 2019 Mar 16.

Phoenix VA Healthcare System, Phoenix, USA.

Lipoapoptosis of cardiomyocytes may underlie diabetic cardiomyopathy. Numerous forms of cardiomyopathies share a common end-pathway in which apoptotic loss of cardiomyocytes is mediated by p38α mitogen activated protein kinase (MAPK). Although we have previously shown that palmitic acid (PA), a saturated fatty acid (SFA) elevated in plasma of type 2 diabetes mellitus and morbid obesity, induces apoptosis in cardiomyocytes via p38α MAPK-dependent signaling, the downstream cascade events that cause cell death remain unknown. Read More

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http://dx.doi.org/10.1007/s10495-018-01510-yDOI Listing

Implementation of an intensified outpatient follow-up protocol improves outcomes in patients with ventricular assist devices.

Clin Res Cardiol 2019 Mar 16. Epub 2019 Mar 16.

Department of Internal Medicine III, Division of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Background: Ventricular assist devices (VAD) are increasingly used as long-term treatment for advanced heart failure. However, survival after VAD implantation is still unsatisfactory, and no specific outpatient follow-up algorithms have been formally established. Here, we evaluate the effect of an intensified follow-up protocol (IFUP) on survival rates and VAD-associated complications. Read More

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http://dx.doi.org/10.1007/s00392-019-01451-9DOI Listing

Long-term follow-up of implantable cardioverter-defibrillators in Short QT syndrome.

Clin Res Cardiol 2019 Mar 16. Epub 2019 Mar 16.

First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Background: Short QT syndrome (SQTS) is associated with sudden cardiac death and implantable cardioverter-defibrillator (ICD) implantation is recommended in this rare disease. However, only a few SQTS families have been reported in literature with limited follow-up data.

Objectives: In the recent study, we describe the outcome data of 57 SQTS patients receiving ICD implantation. Read More

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http://dx.doi.org/10.1007/s00392-019-01449-3DOI Listing

The Significance of Left Axis Deviation in the Pediatric Population: A Meta-Analysis.

Pediatr Cardiol 2019 Mar 16. Epub 2019 Mar 16.

Section of Pediatrics and Section of Cardiology, Department of Medicine, Lakes Region General Hospital, Laconia, NH, USA.

Left axis deviation (LAD) in children is rare but may be associated with structural heart disease. The aim of this study is to systematically assess the significance of LAD in the pediatric population. We included studies listed in PubMed, EMBASE, Web of Science, Cochrane databases, and Google Scholar before May 31, 2018 and their reference lists. Read More

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http://dx.doi.org/10.1007/s00246-019-02086-3DOI Listing

First report of a hybrid robotic beating-heart quadruple totally endoscopic coronary artery bypass: toward complete revascularization.

Eur J Cardiothorac Surg 2019 Mar 16. Epub 2019 Mar 16.

Department of Surgery, Section of Cardiac and Thoracic Surgery, University of Chicago, Chicago, IL, USA.

To the best of our knowledge, this is the first report describing robotic beating-heart quadruple all-arterial totally endoscopic coronary artery bypass combined with percutaneous coronary intervention attempting complete revascularization (residual SYNTAX score 0). A 66-year-old male with severe triple-vessel coronary artery disease underwent percutaneous coronary intervention for a sub-total occlusion of the right coronary artery as the initial component of a hybrid revascularization strategy. Subsequently, the left coronary system was revascularized via robotic beating-heart totally endoscopic coronary artery bypass with bilateral internal mammary artery grafts. Read More

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http://dx.doi.org/10.1093/ejcts/ezz076DOI Listing

Pros and cons of antithrombotic therapy in end-stage kidney disease: a 2019 update.

Nephrol Dial Transplant 2019 Mar 16. Epub 2019 Mar 16.

the Academy of Romanian Scientists (AOSR).

Dialysis patients manifest both an increased thrombotic risk and a haemorrhagic tendency. A great number of patients with chronic kidney disease requiring dialysis have cardiovascular comorbidities (coronary artery disease, atrial fibrillation or venous thromboembolism) and different indications for treatment with antithrombotics (primary or secondary prevention). Unfortunately, few randomized controlled trials deal with antiplatelet and/or anticoagulant therapy in dialysis. Read More

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http://dx.doi.org/10.1093/ndt/gfz040DOI Listing

Brugada electrocardiogram pattern and right bundle branch block: Authors' reply.

Europace 2019 Mar 16. Epub 2019 Mar 16.

Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center Lübeck, Medical Clinic II, University of Lübeck, Ratzeburger Allee 160, Lübeck, Germany.

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http://dx.doi.org/10.1093/europace/euz049DOI Listing

Epicardial ablation for ventricular tachycardia in Freidreich's ataxia cardiomyopathy.

Europace 2019 Mar 16. Epub 2019 Mar 16.

Department of Cardiology, Instituto de Investigación Sanitaria del, Hospital General Universitario Gregorio Marañón, CIBERCV and Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, Madrid, Spain.

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http://dx.doi.org/10.1093/europace/euz030DOI Listing

Brugada electrocardiogram pattern and right bundle branch block.

Europace 2019 Mar 16. Epub 2019 Mar 16.

Department of Medicine, Division of Cardiology, Heart Rhythm Service, Queen's University, Kingston General Hospital, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1093/europace/euz020DOI Listing

Endocarditis after percutaneous edge-to-edge in a heart transplant recipient: management through the HeartPort technique.

Interact Cardiovasc Thorac Surg 2019 Mar 15. Epub 2019 Mar 15.

Division of Thoracic and Cardiovascular Surgery, Pontchaillou University Hospital, Rennes, France.

In the case illustrated in this study, a heart transplant recipient received percutaneous mitral edge-to-edge for secondary mitral regurgitation on the basis of increased reoperative risk. After development of mitral endocarditis, reoperation and mitral valve replacement were successfully performed through the HeartPort technique. We discuss the technical aspects, including the positioning of the Intraclude® device and the access to the mitral valve in this context. Read More

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https://academic.oup.com/icvts/advance-article/doi/10.1093/i
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http://dx.doi.org/10.1093/icvts/ivz052DOI Listing
March 2019
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Adjacent multiple accessory pathways demonstrated on ultra-high-resolution mapping.

Europace 2019 Mar 16. Epub 2019 Mar 16.

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://dx.doi.org/10.1093/europace/euz044DOI Listing

From mitral valve prolapse to catheter ablation.

Eur Heart J 2019 Mar 16. Epub 2019 Mar 16.

Department of Cardiology, University Hospital of Angers, MitoVasc Institute, Mitolab Team, University of Angers, UMR CNRS 6015 - INSERM U1083, 4 rue Larrey, Angers Cedex 9, France.

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http://dx.doi.org/10.1093/eurheartj/ehz139DOI Listing

Misclassification of Myocardial Injury as Myocardial Infarction: Implications for Assessing Outcomes in Value-Based Programs.

JAMA Cardiol 2019 Mar 17. Epub 2019 Mar 17.

Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.

Importance: Similar to other patients with acute myocardial infarction, patients with type 2 myocardial infarction (T2MI) are included in several value-based programs, including the Hospital Readmissions Reduction Program and the Hospital Value-Based Purchasing Program. To our knowledge, whether nonischemic myocardial injury is being misclassified as T2MI is unknown and may have implications for these programs.

Objective: To determine whether patients with nonischemic myocardial injury are being miscoded as having T2MI and if this has implications for 30-day readmission and mortality rates. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.0716DOI Listing

Morphine in acute coronary syndrome: systematic review and meta-analysis.

BMJ Open 2019 Mar 15;9(3):e025232. Epub 2019 Mar 15.

Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.

Objective: Morphine is frequently used in acute coronary syndrome (ACS) due to its analgesic effect, it being recommended in the main cardiology guidelines in Europe and the USA. However, controversy exists regarding its routine use due to potential safety concerns. We conducted a systematic review of randomised-controlled trials (RCTs) and observational studies to synthesise the available evidence. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025232DOI Listing

Delayed diagnosis of coarctation of the aorta with marked collateral circulation.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Department of Cardiology, Japanese Red Cross Ashikaga Hospital, Ashikaga, Japan.

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http://dx.doi.org/10.1136/bcr-2019-229894DOI Listing

Total occlusion of the left main coronary artery presenting as ST-elevation myocardial infarction.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.1136/bcr-2018-228658DOI Listing

Iatrogenic Aortic Regurgitation after Radiofrequency Ablation of Idiopathic Ventricular Arrhythmias Originating from the Aortic Valvular Region.

Heart Rhythm 2019 Mar 13. Epub 2019 Mar 13.

Department of Cardiology, Faculty of Medicine, University of Tsukuba.

Background: Radiofrequency ablation at the aortic root has the potential risk of aortic regurgitation (AR).

Objective: This study investigated the incidence and clinical features of iatrogenic AR after catheter ablation of idiopathic ventricular arrhythmias (VAs) originating from the aortic root.

Methods: We studied 45 consecutive patients with idiopathic VAs originating from the aortic cusps (AC group; n=32) and papillary muscles (control group; n=13) who underwent ablation via a retrograde aortic approach and serial echocardiography before and within 24 hours after the ablation procedure. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.03.010DOI Listing

Can cardiovascular drugs support cancer treatment? The rationale for drug repurposing.

Drug Discov Today 2019 Mar 13. Epub 2019 Mar 13.

Poznan University of Medical Sciences, Chair and Department of Pharmaceutical Chemistry, 6 Grunwaldzka Street, 60-780 Poznan, Poland.

Research on the concept of biological overlap between cardiovascular and oncological diseases is gaining momentum. In fact, in both conditions, the malfunction of common regulatory mechanisms, such as the renin-angiotensin system (RAS), sympathetic nervous system (SNS), coagulation cascade, sodium-potassium ATP-ases, and mevalonate pathway, occurs. Thus, targeting these mechanisms with well-known cardiology drugs, including angiotensin-converting enzyme inhibitors (ACE-Is), angiotensin receptor blockers (ARBs), β-adrenergic receptor blockers, statins, cardiac glycosides (CGs), and low-molecular-weight heparins (LMWHs), could be a novel, promising adjuvant strategy in cancer management. Read More

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http://dx.doi.org/10.1016/j.drudis.2019.03.010DOI Listing

Glycerol derived process contaminants in refined coconut oil induce cholesterol synthesis in HepG2 cells.

Food Chem Toxicol 2019 Mar 13. Epub 2019 Mar 13.

Division of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA; Dell Pediatric Research Institute and the Depts. of Chemistry, of Pediatrics, and of Nutrition, University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX, 78723, USA. Electronic address:

Despite its 50-year history, the conventional diet-heart hypothesis holding that dietary saturated fats raise serum cholesterol, and with it, cardiovascular risk, remains controversial. Harsh chemical and physical treatment generates process contaminants, and refined oils raise serum and tissue cholesterol in vivo independent of saturated fat content. We developed an in vitro bioassay for rapidly assessing the influence of oils on cholesterol metabolism in the human liver HepG2 cell line, and tested it using coconut oil (CO) of various stages of refinement. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.005DOI Listing

Adaptations to Coronary Physiology in a Patient With Severe Aortic Stenosis and Complete Heart Block Undergoing Transcatheter Aortic Valve Replacement.

JACC Cardiovasc Interv 2019 Mar 9. Epub 2019 Mar 9.

Monash Cardiovascular Research Centre and MonashHeart, Monash University and Monash Health, Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2019.01.215DOI Listing

Hemodynamic Effects of Transcatheter Aortic Valve Replacement for Moderate Aortic Stenosis With Reduced Left Ventricular Ejection Fraction.

JACC Cardiovasc Interv 2019 Mar 9. Epub 2019 Mar 9.

Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcentrum, Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2019.01.244DOI Listing

Depression and Angina Among Patients Undergoing Chronic Total Occlusion Percutaneous Coronary Intervention: The OPEN-CTO Registry.

JACC Cardiovasc Interv 2019 Mar 9. Epub 2019 Mar 9.

Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts.

Objectives: This study sought to examine depression prevalence among chronic total occlusion (CTO) patients and compared symptom improvement among depressed and nondepressed patients after percutaneous coronary intervention (PCI).

Background: Depression in cardiovascular patients is common, but its prevalence among CTO patients and its association with PCI response is understudied.

Methods: Among 811 patients from the OPEN-CTO (Outcomes, Patient Health Status, and Efficiency in Chronic Total Occlusion Hybrid Procedures) registry, we evaluated change in health status between baseline and 1-year post-PCI, as measured by the Seattle Angina Questionnaire (SAQ) and the Rose Dyspnea Score. Read More

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http://dx.doi.org/10.1016/j.jcin.2018.12.029DOI Listing

Impact of Intravascular Ultrasound-Guided Percutaneous Coronary Intervention on Long-Term Clinical Outcomes in Patients Undergoing Complex Procedures.

JACC Cardiovasc Interv 2019 Mar 9. Epub 2019 Mar 9.

Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: This study sought to determine whether intravascular ultrasound (IVUS) guidance compared with angiographic guidance reduces long-term risk of cardiac death in patients undergoing complex percutaneous coronary intervention (PCI).

Background: Although IVUS is a useful tool for accurate assessment of lesion profiles and optimal stent implantation, there are limited data on long-term clinical outcomes between IVUS-guided and angiography-guided PCI for patients with complex lesions.

Methods: From March 2003 through December 2015, a total of 6,005 patients undergoing PCI for complex lesions with drug-eluting stents were enrolled from a prospective institutional registry. Read More

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http://dx.doi.org/10.1016/j.jcin.2019.01.227DOI Listing

Non-invasive functional molecular phenotyping of human smooth muscle cells utilized in cardiovascular tissue engineering.

Acta Biomater 2019 Mar 13. Epub 2019 Mar 13.

Department of Women's Health, Research Institute for Women's Health, Eberhard-Karls-University, Tübingen, Germany; Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.

Smooth muscle cell (SMC) diversity and plasticity are limiting factors in their characterization and application in cardiovascular tissue engineering. This work aimed to evaluate the potential of Raman microspectroscopy and Raman imaging to distinguish SMCs of different tissue origins and phenotypes. Cultured human SMCs isolated from different vascular and non-vascular tissues as well as fixed human SMC-containing tissues were analyzed. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.026DOI Listing

Left Atrial Dynamics During Exercise in Mitral Regurgitation of Primary and Secondary Origin: Pathophysiological Insights by Exercise Echocardiography Combined With Gas Exchange Analysis.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Cardiology University Department, Heart Failure Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy; Department for Biomedical Sciences for Health, University of Milano, Milan, Italy. Electronic address:

Objectives: The aim of this study was to identify the pattern of exercise left atrial (LA) dynamics, its gas exchange correlates, and prognosis in mitral regurgitation (MR) of primary and secondary origin.

Background: The adaptive response and clinical significance of LA function during exercise in MR is undefined.

Methods: A total of 196 patients with MR (81 with primary MR, 115 with secondary MR) and 54 control subjects underwent exercise stress echocardiography and cardiopulmonary exercise testing with LA function assessment. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.12.031DOI Listing

Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Department of Cardiovascular Sciences, Glenfield Hospital, Leicester, United Kingdom, and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom. Electronic address:

Objectives: This study used optical coherence tomography to investigate the mechanism of false lumen (FL) formation in spontaneous coronary artery dissection (SCAD) by studying: 1) differences between fenestrated and nonfenestrated SCAD; 2) vasa vasorum density; and 3) light attenuation characteristics of the FL.

Background: SCAD is an increasingly recognized cause of acute coronary syndromes, characterized by FL formation and compression of the true lumen (TL). The mechanisms underlying FL formation remain poorly understood. Read More

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http://dx.doi.org/10.1016/j.jcmg.2019.01.015DOI Listing

Imaging Risk in Multisystem Inflammatory Diseases.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Second Cardiology Department, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Greece.

Rheumatic diseases are immune-mediated inflammatory multisystem diseases with frequent cardiovascular manifestations including perimyocarditis, valvular disease, coronary artery disease, heart failure with or without preserved ejection fraction, pulmonary hypertension, aneurysms, and thrombosis. Echocardiography, carotid ultrasonography, cardiac computed tomography, cardiac magnetic resonance imaging, and positron emission tomography are valid diagnostic tools for the detection of the cardiovascular complications of the multisystem diseases that frequently determine prognosis. Furthermore, the findings of these methods may offer additive risk stratification in asymptomatic patients over the conventional risk scores used to assess cardiovascular risk in the primary prevention setting. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X193017
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http://dx.doi.org/10.1016/j.jcmg.2018.06.033DOI Listing
March 2019
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Coronary Calcium in Type 1 Diabetes: To Screen or Not to Screen?

Authors:
Nathan D Wong

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Division of Cardiology, Heart Disease Prevention Program, University of California, Irvine, Irvine, California. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X193014
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http://dx.doi.org/10.1016/j.jcmg.2019.01.016DOI Listing
March 2019
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Opposing Wall Pushing and Stretching: Response to Cardiac Resynchronization Therapy Requires Electrical Delay and Viability.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.jcmg.2019.01.013DOI Listing

Breast Arterial Calcium: A Game Changer in Women's Cardiovascular Health?

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Department of Cardiology, Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, Maryland; Cardiology Department, Bellvitge University Hospital and Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain; Research Triangle Institute Health Solutions, Pharmacoepidemiology and Risk Management, Barcelona, Spain. Electronic address:

In 2018, cardiovascular disease (CVD) was the leading cause of death among women, and current CVD prevention paradigms may not be sufficient in this group. In that context, it has recently been proposed that detection of calcification in breast arteries may help improve CVD risk screening and assessment in apparently healthy women. This review provides an overview of breast arterial anatomy; and the epidemiology, pathophysiology, and measurement of breast artery calcium (BAC); and discusses the features of the BAC-CVD link. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.07.035DOI Listing
March 2019
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Improvement in the Assessment of Aortic Valve and Aortic Aneurysm Repair by 3-Dimensional Echocardiography.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg/Saar, Germany.

Reconstructive surgery of the aortic valve is being increasingly used in patients with aortic regurgitation and/or aortic aneurysm. Its success depends on restoring normal aortic valve and root form. Echocardiography is the most reliable and precise imaging technique because it defines abnormal morphology and function, essential for selecting appropriate substrates and guiding the surgical strategy. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.06.032DOI Listing

Multiparametric Cardiac Magnetic Resonance Imaging Can Detect Acute Cardiac Allograft Rejection After Heart Transplantation.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Department of Radiology, Northwestern University, Chicago, Illinois; Department of Biomedical Engineering, Northwestern University, Chicago, Illinois.

Objectives: The purpose of this study was to evaluate the sensitivity of multiparametric cardiac magnetic resonance imaging (CMR) for the detection of acute cardiac allograft rejection (ACAR).

Background: ACAR is currently diagnosed by endomyocardial biopsy, but CMR may be a noninvasive alternative because of its capacity for regional myocardial structure and function characterization.

Methods: Fifty-eight transplant recipients (mean age 47. Read More

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http://dx.doi.org/10.1016/j.jcmg.2019.01.026DOI Listing

Cardiac Magnetic Resonance Imaging-Based Right Ventricular Strain Analysis for Assessment of Coupling and Diastolic Function in Pulmonary Hypertension.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center, Giessen, Germany.

Objectives: This study sought to compare cardiac magnetic resonance (CMR) imaging-derived right ventricular (RV) strain and invasively measured pressure-volume loop-derived RV contractility, stiffness, and afterload and RV-arterial coupling in pulmonary hypertension (PH).

Background: In chronic RV pressure overload, RV-arterial uncoupling is considered the driving cause of RV maladaptation and eventual RV failure. The pathophysiological and clinical value of CMR-derived RV strain relative to that of invasive pressure-volume loop-derived measurements in PH remains incompletely understood. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.12.032DOI Listing

The Unrelenting Search for Bioprosthetic Aortic Valve Durability.

Authors:
Mohamad Alkhouli

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Division of Cardiology, West Virginia University School of Medicine, Morgantown, West Virginia. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2019.01.025DOI Listing

Meta-Analysis of the Prognostic Role of Late Gadolinium Enhancement and Global Systolic Impairment in Left Ventricular Noncompaction.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Fondazione Gabriele Monasterio CNR/Regione Toscana, Pisa, Italy. Electronic address:

Objectives: The objective of this meta-analysis was to assess the predictive value of late gadolinium enhancement (LGE) and global systolic impairment for future major adverse cardiovascular events in left ventricular noncompaction (LVNC).

Background: The prognosis of patients with LVNC, with and without left ventricular dysfunction and LGE, is still unclear.

Methods: A systematic review of published research and a meta-analysis reporting a combined endpoint of hard (cardiac death, sudden cardiac death, appropriate defibrillator firing, resuscitated cardiac arrest, cardiac transplantation, assist device implantation) and minor (heart failure hospitalization and thromboembolic events) events was performed. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.12.029DOI Listing

EPA:DHA 6:1 is a superior omega-3 PUFAs formulation attenuating platelets-induced contractile responses in porcine coronary and human internal mammary artery by targeting the serotonin pathway via an increased endothelial formation of nitric oxide.

Eur J Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

UMR CNRS 7213, Faculty of Pharmacy, University of Strasbourg, Illkirch. Electronic address:

At arterial sites of endothelial denudation and dysfunction, activated platelets contribute to vascular injury through the release of potent contracting factors such as serotonin (5-HT). This study evaluated whether omega-3 polyunsaturated fatty acids (PUFAs), known to protect the vascular system, are able to prevent platelets-induced contractile responses in isolated arteries and, if so, to investigate the underlying mechanism and the importance of the omega-3 PUFAs formulation. Porcine coronary arteries (PCA), human internal mammary arteries (IMA) and washed human platelets were prepared and vascular reactivity was studied in organ chambers. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.03.022DOI Listing

Feasibility of implanting 50-60 mm-tapered drug eluting stents in chronic total occlusions.

Cardiovasc Revasc Med 2019 Feb 20. Epub 2019 Feb 20.

Cardiology Department, Hospital Clínico Universitario de Valencia, INCLIVA, Universitat de Valencia, Valencia, Spain; CIBER Cardiovascular, Spain. Electronic address:

Background: Percutaneous coronary intervention (PCI) of chronic total occlusions (CTO) usually involves multiple overlapping stents implantation to cover long coronary segments. A higher rate of restenosis has been described with stent overlapping. Recently, new long tapered stents emerged as a potential tool for treating long coronary lesions. Read More

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http://dx.doi.org/10.1016/j.carrev.2019.02.020DOI Listing
February 2019

Association of autoantibodies against the M2-muscarinic receptor with long-term outcomes in peripartum cardiomyopathy patients: A 5-year prospective study.

J Cardiol 2019 Mar 13. Epub 2019 Mar 13.

Heart Failure Center, Department of Cardiology, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Peripartum cardiomyopathy (PPCM) is characterized by heart failure. Our previous study found that autoantibodies against the M2-muscarinic receptor (anti-M2-R) are increased in PPCM patients. We aimed to evaluate the association of anti-M2-R on prognosis of PPCM patients with standard treatment. Read More

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http://dx.doi.org/10.1016/j.jjcc.2019.02.013DOI Listing

Mechanism, underlying substrate and predictors of atrial tachycardia following atrial fibrillation ablation using the second-generation cryoballoon.

J Cardiol 2019 Mar 13. Epub 2019 Mar 13.

University Heart Center Lübeck, Medical Clinic II (Department of Cardiology, Angiology and Intensive Care Medicine), University Hospital Schleswig-Holstein, Luebeck, Germany. Electronic address:

Background: Data regarding atrial tachycardia (AT) following second-generation cryoballoon ablation (CBA) of atrial fibrillation (AF) are limited.

Aim: To describe the incidence, mechanisms, and clinical predictors of ATs following CBA.

Methods And Results: In this retrospective single-center study 238 patients undergoing CBA for treatment of paroxysmal (91/238; 38. Read More

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http://dx.doi.org/10.1016/j.jjcc.2019.02.006DOI Listing

The Glasgow prognostic score as a significant predictor of clinical outcomes in patients with acute coronary syndrome.

J Cardiol 2019 Mar 13. Epub 2019 Mar 13.

Division of Cardiology, Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, South Korea. Electronic address:

Background: Many studies have reported both systemic inflammatory response and malnutrition provide valuable predictions of prognosis in patients with acute coronary syndrome (ACS). This study aims to assess the association between the Glasgow prognostic score (GPS) by combining C-reactive protein and serum albumin concentration, and clinical outcomes in patients with ACS.

Methods: This retrospective study included patients admitted for ACS between June 2010 and May 2013 in St. Read More

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http://dx.doi.org/10.1016/j.jjcc.2019.02.007DOI Listing

Biomarker assessment for early infarct size estimation in ST-elevation myocardial infarction.

Eur J Intern Med 2019 Mar 14. Epub 2019 Mar 14.

University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. Electronic address:

Background: High-sensitivity cardiac troponin T (hs-cTnT) represents the biomarker of choice for infarct size (IS) estimation in patients with acute ST-elevation myocardial infarction (STEMI). However, admission values of hs-cTnT are only weakly associated with IS. The aim of this study was to investigate the incremental value of different biomarkers measured on admission for IS estimation in STEMI patients. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.03.001DOI Listing

Editorial commentary: Pericardiocentesis: No more a subspecialty technique!

Trends Cardiovasc Med 2019 Feb 5. Epub 2019 Feb 5.

University Cardiology, AOU Città della Salute e della Scienza di Torino, Italy, Corso Bramante 88, 10126 Torino, Italy.

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http://dx.doi.org/10.1016/j.tcm.2019.01.010DOI Listing
February 2019

Effects of single species versus multispecies periodontal biofilms on the antibacterial efficacy of a novel bioactive Class-V nanocomposite.

Dent Mater 2019 Mar 13. Epub 2019 Mar 13.

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

Objective: The objectives of this studywere to: (1) develop a novel bioactive nanocomposite for Class V restorations with subgingival margins to inhibit periodontal pathogens; and (2) investigate if the bioactive nanocomposite could inhibit multi-species periodontal biofilms with a potency as strong as that against single species biofilms.

Methods: Nanocomposite was fabricated using dimethylaminohexadecyl methacrylate (DMAHDM), 2-methacryloyloxyethyl phosphorylcholine (MPC) and nanoparticles of amorphous calcium phosphate (NACP). Biofilms with 1, 3, 6 and 9 species of periodontal pathogens were grown on the composites and tested for live/dead staining, colony-forming units (CFU), metabolic activity, and biofilm matrix polysaccharide production. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01095641183135
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http://dx.doi.org/10.1016/j.dental.2019.02.030DOI Listing
March 2019
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Race-based demographic, anthropometric and clinical correlates of N-terminal-pro B-type natriuretic peptide.

Int J Cardiol 2019 Feb 21. Epub 2019 Feb 21.

Division of Cardiovascular Disease, University of Alabama at Birmingham, 1900 University Blvd., Birmingham, AL, USA; Section of Cardiology, Birmingham Veterans Affairs Medical Center, 700 19th Street S., Birmingham, AL, USA. Electronic address:

Background: Population studies have shown that black race is a natriuretic peptide (NP) deficiency state. We sought to assess whether the effects of age, sex, body mass index (BMI) and estimated glomerular filtration rate (eGFR) on N-terminal-pro-B-type NP (NT-proBNP) levels differ in white and black individuals.

Methods: The study population consisted of a stratified random cohort from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.02.034DOI Listing
February 2019

Cytomegalovirus Infection in Cardiovascular Diseases.

Biochemistry (Mosc) 2018 Dec;83(12):1437-1447

Section on Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Atherosclerosis underlies the development of many cardiovascular diseases that continue to hold a leading place among the causes of death in developed countries. The role of activated immune cells in atherosclerosis progression has been convincingly demonstrated, but the mechanism of their action remains poorly investigated. Since atherosclerosis is associated with chronic inflammatory response, involvement of viral and bacterial infections in atherogenesis has been examined. Read More

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http://dx.doi.org/10.1134/S0006297918120027DOI Listing
December 2018

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi007-A from a Long QT Syndrome type 1 patient carrier of two common variants in the NOS1AP gene.

Stem Cell Res 2019 Mar 6;36:101416. Epub 2019 Mar 6.

Coronary Care Unit and Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Molecular Medicine, Unit of Cardiology, Università degli studi di Pavia, Pavia, Italy.; Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

We generated human induced pluripotent stem cells (hiPSCs) from a symptomatic Long QT Syndrome (LQTS) type 1 patient, belonging to a South African (SA) founder population segregating the heterozygous mutation c.1022C > T p.A341V on the KCNQ1 gene. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101416DOI Listing

One-year clinical outcomes between biodegradable-polymer-coated biolimus-eluting stent and durable-polymer-coated drug-eluting stents in STEMI patients with multivessel coronary artery disease undergoing culprit-only or multivessel PCI.

Atherosclerosis 2019 Mar 3;284:102-109. Epub 2019 Mar 3.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, South Korea.

Background And Aims: There are limited data comparing clinical outcomes among new-generation drug-eluting stents (DES) in ST-segment elevation myocardial infarction (STEMI) patients with multivessel coronary artery disease (MVD) who underwent primary percutaneous coronary intervention (PCI) with culprit-only or multivessel PCI. We investigated 1-year clinical outcomes between biodegradable-polymer (BP)-coated biolimus-eluting stent (BES) and durable-polymer (DP)-coated DES in STEMI patients with MVD who underwent two different reperfusion strategies.

Methods: A total of 4255 patients were enrolled and divided into two groups, a culprit-only (n = 2571, BP- [n = 264] or DP-DES [n = 2307]) or a multivessel PCI group (n = 1684, BP- [n = 145] or DP-DES [n = 1539]). Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.022DOI Listing
March 2019
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Deletion of the KH1 Domain of Fmr1 Leads to Transcriptional Alterations and Attentional Deficits in Rats.

Cereb Cortex 2019 Mar 16. Epub 2019 Mar 16.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene. It is a leading monogenic cause of autism spectrum disorder and inherited intellectual disability and is often comorbid with attention deficits. Most FXS cases are due to an expansion of CGG repeats leading to suppressed expression of fragile X mental retardation protein (FMRP), an RNA-binding protein involved in mRNA metabolism. Read More

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http://dx.doi.org/10.1093/cercor/bhz029DOI Listing
March 2019
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Cardiac Sympathetic Afferent Denervation Protects Against Ventricular Arrhythmias by Modulating Cardiac Sympathetic Nerve Activity During Acute Myocardial Infarction.

Med Sci Monit 2019 Mar 16;25:1984-1993. Epub 2019 Mar 16.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland).

BACKGROUND Augmented cardiac sympathetic afferent reflex (CSAR) plays a role in enhanced sympathetic activity. Given that a strategy for abolishing augmented CSAR-induced sympathetic activation may be beneficial for protecting against ventricular arrhythmias (VAs) triggered by acute myocardial infarction (AMI), we investigated whether cardiac sympathetic afferent denervation (CSAD) could protect against VAs by modulating cardiac sympathetic nerve activity in an AMI dog model. MATERIAL AND METHODS Twenty-two anesthetized dogs were assigned to the CSAD group (n=9) and the sham group (n=13) randomly. Read More

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https://www.medscimonit.com/abstract/index/idArt/914105
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http://dx.doi.org/10.12659/MSM.914105DOI Listing
March 2019
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