367,988 results match your criteria Angiology - The Journal of Vascular Diseases [Journal]


Receipt of Proton-Pump Inhibitors during Pregnancy and Risk for Preeclampsia.

Am J Perinatol 2020 Jul 3. Epub 2020 Jul 3.

Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York.

Objective:  This study aimed to determine whether receiving a proton-pump inhibitor (PPI) prescription during pregnancy was associated with decreased risk for preeclampsia.

Study Design:  The Truven Health MarketScan database was used to determine whether receiving a PPI prescription was associated with risk for preeclampsia. Risk for preeclampsia was evaluated based on the presence or absence of receiving a PPI prescription (1) any time during pregnancy, and 2) individually during the 1st, 2nd, and 3rd trimesters. Read More

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http://dx.doi.org/10.1055/s-0040-1713864DOI Listing

Branch pulmonary artery stent placement in a dog with heart base neoplasia.

J Vet Cardiol 2020 May 23;30:17-22. Epub 2020 May 23.

Department of Cardiology of Clinica Veterinaria Gran Sasso, Via Donatello 26, 20131, Milano, Italy.

A 7-year-old French bulldog was presented for evaluation of cardiac neoplasia. Two-dimensional transthoracic echocardiography revealed a mass on the base of the heart, compressing the right pulmonary artery. Computed tomography exam confirmed that a surgical approach to remove the mass would not be viable. Read More

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http://dx.doi.org/10.1016/j.jvc.2020.05.002DOI Listing

Sleep duration and cardiovascular risk factors in children and adolescents: A systematic review.

Sleep Med Rev 2020 May 19;53:101338. Epub 2020 May 19.

Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address:

An association between short sleep duration and cardiovascular risk factors and outcomes is well demonstrated in adults. However, findings on the association in children and adolescents have been inconsistent. In this review, we searched PubMed, Embase and ISI Web of Science for eligible publications until March 16, 2020. Read More

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http://dx.doi.org/10.1016/j.smrv.2020.101338DOI Listing

MiR-483-3p inhibition ameliorates myocardial ischemia/reperfusion injury by targeting the MDM4/p53 pathway.

Mol Immunol 2020 Jun 30;125:9-14. Epub 2020 Jun 30.

Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, PR China. Electronic address:

MiR-483-3p is involved in the pathogenesis of acute myocardial infarctions, but its association with myocardial ischemia reperfusion (IR) remains mostly unknown. In this study, an in vitro model of myocardial IR injury was established by putting H9c2 cells into hypoxia reoxygenation (HR) treatment to explore the effects and possible mechanisms of miR-483-3p in myocardial IR injury. HR exposure resulted in increased miR-483-3p levels in H9c2 cells. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.06.014DOI Listing

Acute myocardial infarction under-diagnosis and mortality in a Tanzanian emergency department: A prospective observational study.

Am Heart J 2020 Jun 5;226:214-221. Epub 2020 Jun 5.

Duke Global Health Institute, 310 Trent Drive, Durham, NC; Division of Cardiology, Duke University School of Medicine, 2301 Erwin Rd, Durham, NC; Duke Clinical Research Institute, 300 W Morgan St, Durham, NC.

Background: Growing evidence suggests that under-diagnosis of acute myocardial infarction (AMI) may be common in sub-Saharan Africa. Prospective studies of routine AMI screening among patients presenting to emergency departments in sub-Saharan Africa are lacking. Our objective was to determine the prevalence of AMI among patients in a Tanzanian emergency department. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.05.017DOI Listing

Macro-reentrant Biatrial Tachycardia Relevant to Interatrial Septal Incisions after Mitral Valve Surgery: Electrophysiological Characteristics and Ablation Strategy.

Heart Rhythm 2020 Jun 30. Epub 2020 Jun 30.

The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Macroreentrant biatrial tachycardia (BiAT) relevant to interatrial septal incisions following MV surgery has been rarely reported.

Objective: We aimed to assess the mapping and ablation strategy of this special category of atrial tachycardia (AT).

Methods: We identified 10BiATs in a total of 84 ATs after MV surgery performed at three institutions. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.06.031DOI Listing

Common and rare susceptibility genetic variants predisposing to Brugada Syndrome in Thailand.

Heart Rhythm 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Pacific Rim Electrophysiology Research Institute, Bumrungrad Hospital, Bangkok, Thailand.

Background: Mutations in SCN5A are rarely found in Thai patients with Brugada syndrome (BrS). Recent evidence suggested that common genetic variation may underlie BrS in a complex inheritance model.

Objective: To find common and rare/low frequency genetic variants predisposing to BrS in Thailand. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.06.027DOI Listing

Generation of urine-derived iPS cell line via a non-integrative method from a Barth syndrome patient with TAZ gene mutation.

Stem Cell Res 2020 Jun 24;47:101886. Epub 2020 Jun 24.

Center of Scientific Research, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Human urine cells from a 6-year-old male X-linked Barth syndrome patient harboring a TAZ frameshift (c.517delG, Xq28) were reprogrammed into the induced pluripotent stem cell (iPSC) line WMUi002-A using non-integration CytoTune®-iPS 2.0 Sendai Virus Reprogramming kit, including four well-known Yamanaka factors SOX2, OCT4, KLF4, and c-MYC. Read More

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http://dx.doi.org/10.1016/j.scr.2020.101886DOI Listing

Trump Cardiomyopathy: A New Form of Takotsubo.

J Card Fail 2020 May 28. Epub 2020 May 28.

The Christ Hospital, Department of Internal Medicine and Cardiology, Cincinnati, OH.

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http://dx.doi.org/10.1016/j.cardfail.2020.05.016DOI Listing

Activated double-negative T cells (CD3CD4CD8HLA-DR) define response to renal denervation for resistant hypertension.

Clin Immunol 2020 Jun 30:108521. Epub 2020 Jun 30.

Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal; Department of Cardiology, Coimbra's Hospital and University Centre (CHUC), Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Purpose: To explore the cellular immune response of patients with resistant hypertension treated with renal denervation (RDN).

Methods And Results: Twenty-three patients were included and blood samples were obtained in six timings, pre and post procedure. Response was evaluated at six-months and one year and was observed in 69. Read More

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http://dx.doi.org/10.1016/j.clim.2020.108521DOI Listing

First report of a trifecta bioprosthesis sudden onset three leaflet detachment.

Ann Thorac Surg 2020 Jun 30. Epub 2020 Jun 30.

Cardiac Surgery Department, Hospital Universitario Moncloa. Madrid, Spain.

Acute bioprosthesis failure is an uncommon event that may require urgent surgery. This is even less frequent when it is not associated to endocarditis, thombus formation or structural valve deterioration. We describe for the first time an acute complete detachment of the three leaflets of a Trifecta tissue valve six years after the implantation, in a patient who suddenly suffered a strong chest pain with acute dyspnea. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.065DOI Listing

Echocardiographic predictors of recoarctation following surgical repair - a Swedish national study.

Ann Thorac Surg 2020 Jun 30. Epub 2020 Jun 30.

Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Pediatric Cardiology, Lund, Sweden.

Background: Following surgical repair of aortic coarctation (CoA) there is a risk for restenosis (reCoA), particularly in the first year of life. It was the aim of this study to identify reCoA risk factors by analyzing postoperative pre-discharge echocardiograms.

Methods: Retrospective analysis of echocardiograms of children born operated for CoA in Sweden 2011-2017. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.062DOI Listing

Translational Research in Culture: AADAC, Diabetes, and Cardiovascular Disease.

Cell Stem Cell 2020 Jul;27(1):6-7

Department of Medicine/Divsion of Cardiology, and the Cardiovascular Research Center, New York University Grossman School of Medicine, New York, NY, USA. Electronic address:

Many type 2 diabetes patients develop cardiovascular disease (CVD) while some are protected. Toyohara et al. (2020) find that elevated arylacetamide deacetylase (AADAC) expression in vascular smooth muscle cells (dVSMCs) differentiated from patient-derived induced pluripotent stem cells is associated with cardioprotection. Read More

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http://dx.doi.org/10.1016/j.stem.2020.06.012DOI Listing

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes.

Cell Stem Cell 2020 Jul;27(1):50-63.e5

Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in vitro can expand CMs modestly (<5-fold). Here, we demonstrate massive expansion of hiPSC-CMs in vitro (i. Read More

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http://dx.doi.org/10.1016/j.stem.2020.06.001DOI Listing

Reply.

J Pediatr 2020 Jun 30. Epub 2020 Jun 30.

Department of Pediatrics, Rady Children's Hospital, University of California San Diego, San Diego, CA USA.

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http://dx.doi.org/10.1016/j.jpeds.2020.06.072DOI Listing

A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and Their Differentiated Derivatives.

Stem Cell Reports 2020 Jun 23. Epub 2020 Jun 23.

Department of Pathology, University of Washington, Seattle, WA 98109, USA; The Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA. Electronic address:

Single-cell transcriptomic approaches have found molecular heterogeneities within populations of pluripotent stem cells (PSCs). A tool that tracks single-cell lineages and their phenotypes longitudinally would reveal whether heterogeneity extends beyond molecular identity. Hence, we generated a stable Cre-inducible rainbow reporter human PSC line that provides up to 18 unique membrane-targeted fluorescent barcodes. Read More

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http://dx.doi.org/10.1016/j.stemcr.2020.06.005DOI Listing

Interpreting Administrative Data About Transcatheter Aortic Valve Replacement Effects on Hospitalisation Outcomes: The Devil's in the Details.

Can J Cardiol 2020 Apr 14. Epub 2020 Apr 14.

Institut de Cardiologie de Montréal, Department of Cardiology, Université de Montréal, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2020.03.050DOI Listing

Precision Medicine in TAVR: How to Select the Right Device for the Right Patient.

Can J Cardiol 2020 Apr 6. Epub 2020 Apr 6.

Sorbonne University, ACTION Group, INSERM UMRS 1166, Institut de Cardiologie, Hôpital Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/j.cjca.2020.03.043DOI Listing

Obese but Fit: The Benefits of Fitness on Cognition in Obese Older Adults.

Can J Cardiol 2020 Jan 16. Epub 2020 Jan 16.

Centre de médecine préventive et d'activité physique (Centre ÉPIC), Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada; Research Center, Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Background: Obesity is associated with an accelerated cognitive decline. Aerobic fitness has a protective effect on cognition in older adults, but no study has investigated this effect in obese individuals. The present study aimed to 1) compare cognitive function in lower-fit (LoFit) and higher-fit (HiFit) obese individuals compared with nonobese individuals, and 2) examine the association between exercise variables (including hemodynamic variables) and cognitive function in obese individuals. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.01.005DOI Listing
January 2020

Anti-Inflammatory Therapy in Rheumatoid Arthritis to Improve Cardiovascular Outcome.

Can J Cardiol 2020 Mar 27. Epub 2020 Mar 27.

Division of Cardiology, American University Hospital and American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.1016/j.cjca.2020.03.023DOI Listing

Pathophysiological Mechanisms Underlying Excess Risk for Diabetes and Cardiovascular Disease in South Asians: The Perfect Storm.

Curr Diabetes Rev 2020 Jul 3. Epub 2020 Jul 3.

Health Policy, Quality & Informatics Program, Michael E. DeBakey Veterans Affairs Medical Center Health Services Research and Development Center for Innovations; Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, Texas. United States.

Background: South Asians are at a significantly increased risk of type 2 diabetes (T2D) and cardiovascular disease (CVD), are diagnosed at relatively younger ages, and exhibit more severe disease phenotypes as compared with other ethnic groups. The pathophysiological mechanisms underlying T2D and CVD risk in South Asians are multifactorial and intricately related.

Method: Narrative review of the pathophysiology of excess risk of T2D and CVD in South Asians. Read More

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http://dx.doi.org/10.2174/1573399816666200703182458DOI Listing

Remote ischaemic conditioning in patients with ST-elevation myocardial infarction treated with percutaneous coronary intervention: an updated meta-analysis of clinical outcomes.

Acta Cardiol 2020 Jul 3:1-9. Epub 2020 Jul 3.

Department of Cardiology, Deutsches Hospital, Buenos Aires, Argentina.

All previous meta-analyses including clinical outcomes after remote ischaemic conditioning (RIC) in patients with ST-elevation myocardial infarction STEMI) treated with percutaneous coronary intervention (PCI) demonstrated that RIC significantly reduced all-cause mortality and major adverse cardiovascular events (MACE). Following the publication of these meta-analyses, three new randomised controlled clinical trials (RCT) including 5712 patients were reported. The objective of this study was to perform an updated meta-analysis about the effectiveness of RIC in reducing MACE in patients with STEMI undergoing PCI. Read More

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http://dx.doi.org/10.1080/00015385.2020.1766259DOI Listing

Characterization of dendritic cells in human and experimental myocarditis.

ESC Heart Fail 2020 Jul 3. Epub 2020 Jul 3.

Department of Internal Medicine I, Division of Cardiology, University Hospital Jena, Jena, Germany.

Aims: Dendritic cells (DCs) are central mediators of adaptive immunity, and there is growing evidence of their role in myocardial inflammatory disease. We hypothesized that plasmacytoid and myeloid DCs are involved in the mechanisms of myocarditis and analysed these two main subtypes in human myocarditis subjects, as well as in a murine model of experimental autoimmune myocarditis (EAM).

Methods And Results: Circulating DCs were analysed by flow cytometry in patients with acute myocarditis, dilated cardiomyopathy, and controls. Read More

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http://dx.doi.org/10.1002/ehf2.12767DOI Listing

Regional Adiposity and Heart Failure with Preserved Ejection Fraction.

Eur J Heart Fail 2020 Jul 3. Epub 2020 Jul 3.

Division of Cardiology, Duke University School of Medicine, Durham, North Carolina, United States.

The role of obesity in the pathogenesis of heart failure (HF), and in particular HF with preserved ejection fraction (HFpEF), has drawn significant attention in recent years. The prevalence of both obesity and HFpEF has increased worldwide over the past decades and when present concomitantly suggests an obese-HFpEF phenotype. Anthropometrics, including body mass index (BMI), waist circumference (WC), and waist-hip-ratio (WHR), are associated with incident HFpEF. Read More

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http://dx.doi.org/10.1002/ejhf.1956DOI Listing

Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans.

FASEB J 2020 Jul 3. Epub 2020 Jul 3.

Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

Chronic graft-vs-host disease (cGVHD) is a multifactorial inflammatory disease that affects patients undergoing hematopoietic stem cell transplantation. Multiple organs, including the lacrimal glands (LGs), are negatively affected by cGVHD and lose function due to the resultant fibrosis. An abnormal immune response is thought to be a major factor in the development of chronic ocular GVHD, which is currently treated primarily with immunosuppressive therapies. Read More

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http://dx.doi.org/10.1096/fj.201900218RDOI Listing

Conditional Survival after Surgery for Patients with Penile Cancer.

Andrology 2020 Jul 3. Epub 2020 Jul 3.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Penile cancer represents a rare pathology whose natural history of treatment is poorly understood.

Objective: To illustrate the dynamic survival profiles in surgically treated patients with squamous cell carcinoma of the penis (SCCP) using the conditional survival (CS) estimates.

Materials And Methods: Patients with non-metastatic SCCP were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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http://dx.doi.org/10.1111/andr.12856DOI Listing

Towards a lesion-specific approach to percutaneous coronary intervention for bifurcation lesions.

Eur Heart J 2020 Jul 3. Epub 2020 Jul 3.

Division of Cardiology and Angiology II, University Heart Centre Freiburg - Bad Krozingen, Bad Krozingen, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehaa559DOI Listing

Short Peripheral Catheter Dwell Time and Associated Complications: A Systematic Review.

J Infus Nurs 2020 Jul/Aug;43(4):200-207

Tripler Army Medical Center, Honolulu, Hawaii (Dr Hopkinson, Ms Green and Ms Hewitt); Brooke Army Medical Center, Fort Sam Houston, Texas (Ms Grace). Susan G. Hopkinson, PhD, MSN, is the chief of the Center for Nursing Science & Clinical Inquiry at Tripler Army Medical Center in Honolulu, Hawaii. She is responsible for overseeing nursing-sensitive research and evidence-based practice initiatives within the organization. Angela K. Green, MSHA, BSN, is the clinical nurse officer in charge at the Medical/Surgical Unit at Tripler Army Medical Center. She practices internal medicine and family practice in adult patients with acute and chronic medical conditions. Brenda E. Hewitt, BSN, RN, CEN, is a staff nurse at the Cardiology Clinic at Tripler Army Medical Center. She is responsible for managing the pacemaker/device clinic, patient education, administering cardiac stress tests, and treating patients with heart failure and medication titrations. Sara A. Grace, BSN, is an intensive care unit staff nurse at Brooke Army Medical Center in Houston, Texas.

There is evidence that the risk of complications caused by short peripheral catheters (SPCs) does not increase when SPCs are replaced due to clinical indication versus at a specific time frame. In the studies, however, the dwell time does not typically exceed an average of 3.5 days. Read More

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http://dx.doi.org/10.1097/NAN.0000000000000374DOI Listing

Anakinra And Etanercept Combination Treatment in a Child With Severe, Nonresponsive Kawasaki Disease.

Pediatr Infect Dis J 2020 Jun 30. Epub 2020 Jun 30.

From the Department of Pediatric Cardiology and Pediatric Intensive Care, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

Kawasaki disease (KD) patients' resistance to treatment with intravenous immunoglobulins (IVIG) places them at high risk for an unfavorable progression of the disease. In these patients, there has been little evidence that alternative treatments are effective. Nevertheless, biologicals such as an interleukin-1-receptor blocker and tumor-necrosis-factor-α inhibitors increasingly have been used. Read More

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http://dx.doi.org/10.1097/INF.0000000000002810DOI Listing

Circadian variations in blood pressure and their implications for the administration of antihypertensive drugs: is dosing in the evening better than in the morning?

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

University of Milano-Bicocca, Milan, Italy.

: Blood pressure (BP) follows a circadian rhythm with a physiological decrease during the night. Studies have demonstrated that nocturnal BP as well as its dipping pattern during night-time have a significant prognostic importance for mortality and the occurrence of cardiovascular events. Therefore, hypertension management guidelines recommend to ascertain that patients treated for hypertension have well controlled BP values around the clock. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002532DOI Listing

Subtype diagnosis, treatment, complications and outcomes of primary aldosteronism and future direction of research: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension.

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

3rd Department of Medicine, Center for Hypertension, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic.

: Primary aldosteronism is a frequent cause of secondary hypertension requiring a specific pharmacological treatment with mineralocorticoid receptor antagonist or with unilateral adrenalectomy. These treatments have shown to reduce the excess of cardiovascular risk characteristically associated with this disease. In part I of this consensus, we discussed the procedures for the diagnosis of primary aldosteronism. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002520DOI Listing

Genetics, prevalence, screening and confirmation of primary aldosteronism: a position statement and consensus of the Working Group on Endocrine Hypertension of The European Society of Hypertension.

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

3rd Department of Medicine, Center for Hypertension, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic.

: Autonomous aldosterone overproduction represents the underlying condition of 5-10% of patients with arterial hypertension and carries a significant burden of mortality and morbidity. The diagnostic algorithm for primary aldosteronism is sequentially based on hormonal tests (screening and confirmation tests), followed by lateralization studies (adrenal CT scanning and adrenal venous sampling) to distinguish between unilateral and bilateral disease. Despite the recommendations of the Endocrine Society guideline, primary aldosteronism is largely underdiagnosed and undertreated with high between-centre heterogeneity. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002510DOI Listing

Cardiac magnetic resonance-derived fibrosis, strain and molecular biomarkers of fibrosis in hypertensive heart disease.

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

Cardiovascular Unit, ASCIRES Medical Group, Valencia.

Aims: Myocardial fibrosis is a relevant component of hypertensive heart disease (HHD). Novel cardiovascular magnetic resonance (CMR) imaging techniques have shown potential in quantification of diffuse cardiac fibrosis, with T1 mapping, and estimating preclinical cardiac dysfunction, with strain analysis. Molecular biomarkers of fibrosis have been related with clinical outcomes and histologically proven myocardial fibrosis. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002504DOI Listing

High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia.

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands.

Objective: Preeclampsia is associated with an elevated risk of cardiovascular disease later in life. Women with a history of preeclampsia are at risk of developing hypertension as well as ischemic heart disease. Identification of women at the highest risk is important to initiate preventive strategies. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002497DOI Listing

Heart failure and renal outcomes according to baseline and achieved blood pressure in patients with type 2 diabetes: results from EMPA-REG OUTCOME.

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

Klinik für Innere Medizin III, Saarland University Medical Center, Homburg/Saar, Germany.

Background: The sodium-glucose co-transporter 2 (SGLT2) inhibitor empagliflozin reduced cardiovascular death or heart failure hospitalizations in type 2 diabetes (T2D) in addition to a reduction of SBP. As heart failure patients often present with low SBP, which can challenge treatment initiation, we explored if empagliflozin's effect on SBP was independent of baseline SBP and heart failure status, and if the effect on cardiovascular and heart failure outcomes was influenced by updated mean SBP or by an early change in SBP after drug initiation.

Methods And Results: A total of 7020 patients were treated with empagliflozin 10 mg, 25 mg or placebo and followed for a median of 3. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002492DOI Listing

Childhood Viral Respiratory Infection and Congenital Heart Disease: Many Questions Remain Unanswered.

Pediatr Crit Care Med 2020 Jul;21(7):694-696

Department of Cardiology, Boston Children's Hospital, Boston, MA; and Department of Pediatrics, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/PCC.0000000000002372DOI Listing

The new era of chest pain evaluation in the Netherlands.

Eur J Emerg Med 2020 Aug;27(4):243-244

Department of Cardiology, Leiden University Medical Centre, Leiden, Zuid-Holland, Netherlands.

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http://dx.doi.org/10.1097/MEJ.0000000000000711DOI Listing

Severe hypoxaemia during pneumoperitoneum for laparoscopic appendicectomy because of atrial septal defect.

J Cardiovasc Med (Hagerstown) 2020 Aug;21(8):618-619

Department of Cardiology, Santa Maria della Misericordia, Rovigo, Italy.

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http://dx.doi.org/10.2459/JCM.0000000000000946DOI Listing

Percutaneous coronary intervention in dextrocardia: a case report and a brief review of the literature.

J Cardiovasc Med (Hagerstown) 2020 Aug;21(8):613-615

Interventional Cardiology Unit, Azienda Ospedaliera Universitaria di Parma, Parma, Italy.

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http://dx.doi.org/10.2459/JCM.0000000000000927DOI Listing

Late atrial arrhythmias after lung transplantation: a meta-analysis.

J Cardiovasc Med (Hagerstown) 2020 Aug;21(8):577-582

Division of Cardiology, Department of Medical Sciences, 'Città della Salute e della Scienza di Torino' Hospital, University of Turin, Turin.

Background: Atrial arrhythmias are common following noncardiac thoracic surgery. In particular, early postoperative atrial arrhythmias after lung transplantation are very frequent, especially atrial fibrillation (AFib). Late atrial arrhythmia occurrence following lung transplantation, instead, has been less commonly reported. Read More

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http://dx.doi.org/10.2459/JCM.0000000000001012DOI Listing

Thromboelastography Profiles of Critically Ill Patients With Coronavirus Disease 2019.

Crit Care Med 2020 Jun 26. Epub 2020 Jun 26.

Leon H. Charney Division of Cardiology, Department of Medicine, NYU Langone Health, New York, NY.

Objectives: The rate of thromboembolic events among patients with coronavirus disease 2019 is high; however, there is no robust method to identify those at greatest risk. We reviewed thromboelastography studies in critically ill patients with coronavirus disease 2019 to characterize their coagulation states.

Design: Retrospective. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004471DOI Listing

For Your Service... Commentary on "For Your Service..."

Acad Med 2020 Jun 30. Epub 2020 Jun 30.

Q.R. Youmans is a fellow in cardiology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; email: twitter: @QuentinYoumans; ORCID: https://orcid.org/0000-0001-5818-8091.

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http://dx.doi.org/10.1097/ACM.0000000000003562DOI Listing

Off-pump ascending aorta or aortic arch to descending aorta bypass with a pericardial roll for the treatment of critically ill infants with interrupted aortic arch.

Cardiol Young 2020 Jun 18:1-8. Epub 2020 Jun 18.

Department of Cardiovascular Surgery, Istanbul Medipol University Medical Faculty, Istanbul, Turkey.

Aim: Standard surgical treatment of the interrupted aortic arch with the use of cardiopulmonary bypass is risky especially in critically ill babies. In this manuscript, we present the results of off-pump pericardial roll bypass for the treatment of aortic interruption.

Material And Methods: The technique was applied in nine critically ill infants between July 2011 and December 2019. Read More

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http://dx.doi.org/10.1017/S1047951120001687DOI Listing

Image-based scaling laws for somatic growth and pulmonary artery morphometry from infant- to adulthood.

Am J Physiol Heart Circ Physiol 2020 Jul 3. Epub 2020 Jul 3.

Pediatrics Cardiology, Stanford University, United States.

Pulmonary artery (PA) morphometry has been extensively explored in adults, with particular focus on intra-acinar arteries. However, scaling law relationships for length and diameter of extensive pre-acinar PAs by age have not been previously reported for in vivo human data. To understand pre-acinar PA growth spanning children to adults, we performed morphometric analyses of all PAs visible in the computed tomography (CT) and magnetic resonance (MR) images from a healthy subject cohort (n=16; age: 1-51 years; body surface area, BSA: 0. Read More

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http://dx.doi.org/10.1152/ajpheart.00123.2020DOI Listing

Progesterone promotes endothelial nitric oxide synthase expression through enhancing nuclear progesterone receptor-SP1 formation.

Am J Physiol Heart Circ Physiol 2020 Jul 3. Epub 2020 Jul 3.

Cardiology, The First Affiliated Hospital of Chongqing Medical University, China.

Progesterone exerts antihypertensive actions partially by modulating endothelial nitric oxide synthase (eNOS) activity. Here, we aimed to investigate the effects and mechanisms of progesterone on eNOS expression. Firstly,HUVECs (human umbilical vein endothelial cells) were exposed to progesterone, then the eNOS、transcription factor SP1 (Specificity protein 1) and PR-A/B (progesterone receptor) expression were assessed by Western blotting and qRT-PCR. Read More

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http://dx.doi.org/10.1152/ajpheart.00206.2020DOI Listing

Three-Year Outcomes of Orbital Atherectomy for the Endovascular Treatment of Infrainguinal Claudication or Chronic Limb-Threatening Ischemia.

J Endovasc Ther 2020 Jul 3:1526602820935611. Epub 2020 Jul 3.

Division of Cardiology, Rocky Mountain Regional VA Medical Center, University of Colorado, Denver, CO, USA.

To investigate the outcomes of orbital atherectomy (OA) for the treatment of patients with peripheral artery disease (PAD) manifesting as claudication or chronic limb-threatening ischemia (CLTI). The database from the LIBERTY study ( identifier NCT01855412) was interrogated to identify 503 PAD patients treated with any commercially available endovascular devices and adjunctive OA for 617 femoropopliteal and/or infrapopliteal lesions. Cox regression analyses were employed to examine the association between baseline Rutherford category (RC) stratified as RC 2-3 (n=214), RC 4-5 (n=233), or RC 6 (n=56) and all-cause mortality, target vessel revascularization (TVR), major amputation, major adverse event (MAE), and major amputation/death at up to 3 years of follow-up. Read More

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http://dx.doi.org/10.1177/1526602820935611DOI Listing

Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin-induced cardiotoxicity.

Clin Transl Med 2020 Jul 3. Epub 2020 Jul 3.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, P. R. China.

Background: Inflammation, oxidative stress, and apoptosis contribute to the evolution of doxorubicin (DOX)-induced cardiotoxicity. Osteocrin (OSTN) is a novel secretory peptide mainly derived from the bone and skeletal muscle, and plays critical roles in regulating bone growth and physical endurance. Inspiringly, OSTN was also reported to be abundant in the myocardium that functioned as a therapeutic agent against cardiac rupture and congestive heart failure in mice after myocardial infarction. Read More

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http://dx.doi.org/10.1002/ctm2.124DOI Listing