1,033 results match your criteria Angiokeratoma Circumscriptum
Dermatol Ther (Heidelb) 2018 Nov 26. Epub 2018 Nov 26.
San Diego Family Dermatology, National City, CA, USA.
Scrotal rejuvenation encompasses not only the functional quality but also the aesthetic appearance of the scrotum. It includes medical therapy and procedural interventions to improve scrotal conditions that require morphologic restoration and/or aesthetic alteration. Rejuvenation of the scrotum may be appropriate for aging-related and non-aging-related changes concerning the hair (alopecia and hypertrichosis), the morphology (laxity and wrinkles), and/or the vascularity (angiokeratoma) of the scrotum. Read More
Ther Umsch 2018 Nov;75(4):217-224
3 Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zürich.
Fabry disease - the profile of an orphan disease Abstract. Fabry disease is a lysosomal storage disease, characterized by a deficient lysosomal function. The main pathophysiological mechanism is the deficiency of the enzyme α-galactosidase A. Read More
Pan Afr Med J 2018 19;30:140. Epub 2018 Jun 19.
Service de Dermatologie-Vénérologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.
Angiokeratomas are vascular dilations (telangiectasic papules) with keratotic surface caused by capillary dilation in the dermal papilla due to venous hyperpression, vascular malformation or a capillary fragility. They most commonly are benign and just unsightly and they may sometimes reveal a dreaded overload disease known as Fabry Disease. Here we report the case of a 56-year old patient, with no notable medical history, presenting with nontraumatic, nonpruritic, bleeding on contact, grouped cluster erythematous papules without extracutaneous manifestations on the left malar region, that had occurred 4 months before. Read More
Pediatr Dermatol 2018 Oct 15. Epub 2018 Oct 15.
Department of Pathology & Laboratory Medicine, Weill Cornell Medicine, New York, New York.
Acral pseudolymphomatous angiokeratoma of children (APACHE) and unilesional mycosis fungoides (MF) are two rare dermatoses in the pediatric population which may have overlapping clinical and histopathologic features, making differentiation between these two diagnoses difficult. We present two similar cases of a solitary plaque on the thigh of a child, one representing APACHE and the other representing unilesional MF with granulomatous features, and we provide a brief overview of the clinical and histopathologic features of APACHE and unilesional MF. Read More
Skin Appendage Disord 2018 Aug 8;4(3):152-155. Epub 2017 Nov 8.
Dermatology Department, CHU Brugmann and CHU Saint-Pierre, Université Libre de Bruxelles, Belgium.
Subungual angiokeratoma is extremely rare. Only 1 case is reported in the literature, presenting as a longitudinal pigmented band on a toenail. We report a case of a subungual angiokeratoma on a fingernail of a 43-year-old woman, clinically mimicking a squamous cell carcinoma. Read More
Dermatol Ther 2018 09 7;31(5):e12682. Epub 2018 Sep 7.
Unit of Dermatology and Cosmetology, IRCCS University Vita-Salute San Raffaele, Milan, Italy.
An Bras Dermatol 2018 Sep-Oct;93(5):712-715
Dermatology Department and Public Health Dermatology Outpatient Clinic, Porto Alegre, Rio Grande do Sul State Health Department, Porto Alegre (RS), Brazil.
Verrucous hemangioma is a rare vascular skin disorder with an immune profile similar to vascular neoplasms, but with behavior and evolution of vascular malformations. Its main differential diagnosis is angiokeratoma circumscriptum neviforme, with an almost indistinguishable clinical presentation because both diseases appear as erythematous patches that evolve to violaceous plaques, becoming scaly and even verrucous, most commonly affecting the lower limbs. Histopathology is crucial for the correct diagnosis: while in angiokeratoma the vascular alterations are limited to the papillary dermis, verrucous hemangioma extends deep into the dermis, reaching the subcutaneous tissue. Read More
Am J Nephrol 2018 15;48(2):137-146. Epub 2018 Aug 15.
Background: Fabry disease (FD) with life-threatening complications occurs as a result of organ damage in kidneys, heart, and brain. Only a few studies, especially from Asia, report their long-term outcome.
Methods: In this monocentric study, patients with Fabry nephropathy confirmed by renal biopsy were clinically investigated in a comprehensive manner. Read More
Pan Afr Med J 2018 6;29:202. Epub 2018 Apr 6.
Service de Dermatologie, CHU Hassan II, Fes, Maroc.
Superficial circumscribed lymphangiomas are predominantly benign lesions occuring in the cervicofacial area. These malformations of the lymphatic vessels are frequently diagnosed in children. We report the clinical case of lymphangioma of the tongue that occurred in an old man. Read More
Biomed J 2018 Jun 11;41(3):209-210. Epub 2018 Jul 11.
Department of Dermatology, Hassan II University Hospital of Fez, Fez, Morocco.
The rainbow pattern is currently a subject of debate, it is considered the specific dermoscopic pattern of Kaposi sarcoma. We present in this research correspondence a review of 700 dermoscopic figures of different biopsy-proven skin diseases in our department of dermatology of the Hospital Hassan II of Fez. All the lesions were localized to the limbs except for one lesion of atrophic scar that was localized on the left shoulder. Read More
Ann Dermatol Venereol 2018 Aug - Sep;145(8-9):552-553. Epub 2018 Jul 21.
Service de dermatologie, GHR Mulhouse Sud-Alsace, 20, avenue Dr René-Laennec, 68100 Mulhouse, France.
Mol Genet Metab Rep 2018 Jun 6;15:43-45. Epub 2018 Feb 6.
Salford Royal NHS Foundation Trust Stott Lane, Salford M6 8HD, United Kingdom.
Fabry disease is an X-linked metabolic disorder resulting in widespread deposition of Globotriaosylceramide within a variety of human tissues. The classical Fabry phenotype is one of early onset disease, with extensive tissue involvement resulting in acroparaesthesia, gastrointestinal disturbances, angiokeratoma, cornea verticillata renal failure, and cardiovascular disease. We describe two brothers exhibiting the GLA p. Read More
Appl Immunohistochem Mol Morphol 2018 Jul;26(6):411-419
Department of Pathology, University of Valencia, Valencia, Spain.
High-endothelial venules are a common feature of 3 types of cutaneous pseudolymphomas: pretibial lymphoplasmacytic plaque (PLP) of children, acral pseudolymphomatous angiokeratoma of children (APACHE), and T-cell rich angiomatoid polypoid pseudolymphoma (TRAPP). In addition, primary cutaneous angioplasmacellular hyperplasia (PCAH) overlaps with these other 3 conditions. We intend to study the expression of peripheral node addressins in PLP, APACHE, TRAPP, and PCAH. Read More
An Bras Dermatol 2018 Jun;93(3):426-428
Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Fabry disease is a rare lysosomal storage disorder, inherited in an X-linked manner. It is characterized by the deficiency of the enzyme alpha-galactosidase, leading to a buildup of glycosphingolipids in the cells. Angiokeratoma is one of the cutaneous manifestations of this condition, and it helps making the diagnosis. Read More
Cutis 2018 05;101(5):E6-E7
Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
J Dtsch Dermatol Ges 2018 Jun;16(6):769-771
Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine University of Bologna, Italien.
Clin Res Cardiol 2018 Dec 24;107(12):1111-1121. Epub 2018 May 24.
Department of Internal Medicine I, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Objectives: To evaluate potential risk factors for stroke or transient ischemic attacks (TIA) and to test the feasibility and efficacy of a Fabry-specific stroke risk score in Fabry disease (FD) patients without atrial fibrillation (AF).
Background: FD patients often experience cerebrovascular events (stroke/TIA) at young age.
Methods: 159 genetically confirmed FD patients without AF (aged 40 ± 14 years, 42. Read More
J Dtsch Dermatol Ges 2018 Jun 22;16(6):769-771. Epub 2018 May 22.
Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine University of Bologna, Italy.
J Clin Aesthet Dermatol 2018 May 1;11(5):43-47. Epub 2018 May 1.
Dr. Tas is with the Health Sciences University, Istanbul Bagcilar Research and Training Hospital, Department of Dermatology in Istanbul, Turkey.
We present the case of a 15-year-old girl who presented with an unusual grouping of lesions on her upper left leg. The lesions had been present since birth. The patient had five different types of lesions: 1) transparent grouped or scattered yellowish vesicles; 2) keratotic-surfaced, grouped dark-yellowish papules; 3) bright-red grouped papules; 4) keratotic-surfaced grouped dark-red papules; and 5) patchy, punctate, and erythematous red macules. Read More
Cureus 2018 Mar 13;10(3):e2316. Epub 2018 Mar 13.
Department of Dermatology, University of California, San Diego.
Genital rejuvenation is applicable not only to women (vaginal rejuvenation) but also to men (scrotal rejuvenation). There is an increased awareness, reflected by the number of published medical papers, of vaginal rejuvenation; however, rejuvenation of the scrotum has not received similar attention in the medical literature. Scrotal rejuvenation includes treatment of hair-associated scrotal changes (alopecia and hypertrichosis), morphology-associated scrotal changes (wrinkling and laxity), and vascular-associated scrotal changes (angiokeratomas). Read More
Indian Dermatol Online J 2018 Mar-Apr;9(2):141-142
Department of Dermatology and STD, Sanjay Gandhi Memorial Hospital, New Delhi, India.
Skin Therapy Lett 2018 03;23(2):4-6
Baywood Dermatology, Ajax, ON, Canada; CCA Medical Research, Ajax, ON, Canada; St. Michael's Hospital, Toronto, ON, Canada; Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada; Probity Medical Research, Waterloo, ON, Canada.
Fabry disease (FD) is an X-linked lysosomal storage disease. A lack of alpha-galactosidase activity results in the accumulation of globotriaosylceramide in cells of various systems, leading to multi-systemic effects. The cutaneous hallmark of FD is a specific distribution of angiokeratoma. Read More
Exp Dermatol 2018 Jun;27(6):663-667
Center For Research in Genetics and Genomics-CIGGUR, GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Fucosidosis is a rare lysosomal storage disease which has been classified into two subtypes, depending on the severity of clinical signs and symptoms. Fucosidosis patients' skin abnormalities include angiokeratoma corporis diffusum, widespread telangiectasia, thick skin, hyperhidrosis and hypohidrosis, acrocyanosis and distal transverse nail bands. It has been described that >50% of fucosidosis patients have angiokeratoma. Read More
Curr Genomics 2018 Jan;19(1):70-75
Center for Experimental Medicine and Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha410013, China.
Introduction: Fabry Disease (FD), the second most common lysosomal storage disorder after Gaucher disease, is characterized by variable clinical manifestations, including angiokeratoma, corneal dystrophy, recurrent episodes of extremity pain, renal impairment, cardiac complications and cerebrovascular manifestations. It is caused by mutations in the α-galactosidase A gene (gene symbol GLA) on chromosome Xq22, which leads to deficiency of lysosomal α-galactosidase A (α-Gal A), and subsequent accumulation of glycosphingolipids in various tissues and organs. The aim of this study is to identify the disease-causing mutation in a five-generation Chinese family with FD. Read More
Indian J Dermatol Venereol Leprol 2018;84(2):230-231
Department of Dermatology, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Mol Genet Metab Rep 2018 Mar 22;14:68-72. Epub 2017 Dec 22.
Advanced Clinical Research Center, Institute of Neurological Disorders, Shin-Yurigaoka General Hospital, Kawasaki, Kanagawa, Japan.
Fabry disease is an X-linked lysosomal storage disorder caused by a deficiency of α-galactosidase A (α-gal A), leading to the progressive accumulation of glycosphingolipids. Classical hemizygous males usually present symptoms, including pain and paresthesia in the extremities, angiokeratoma, hypo- or anhidrosis, abdominal pain, cornea verticillata, early stroke, tinnitus, and/or hearing loss, during early childhood or adolescence. Moreover, proteinuria, renal impairment, and cardiac hypertrophy can appear with age. Read More
J Eur Acad Dermatol Venereol 2018 Jun 24;32(6):879-888. Epub 2018 Jan 24.
First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. Read More
Dermatol Ther 2017 Nov 19;30(6). Epub 2017 Nov 19.
Department of Dermatology, University of California Irvine School of Medicine, Irvine, California.
Angiokeratomas can present therapeutic challenges, especially in cases of extensive lesions, where traditional surgical methods carry high risks of scarring and hemorrhage. Argon, pulsed dye (PDL), neodymium-doped yttrium aluminum garnet (Nd:YAG), copper vapor, potassium titanyl phosphate, carbon dioxide, and erbium-doped yttrium aluminum garnet (Er:YAG) lasers have emerged as alternative options. To review the use and efficacy of lasers in treating angiokeratomas. Read More
Skinmed 2017 1;15(5):343-347. Epub 2017 Oct 1.
Department of Dermatology, University of California San Diego School of Medicine, La Jolla, CA;
Angiokeratomas are benign vascular lesions characterized by ectatic blood vessels in the papillary dermis with overlying acanthosis and hyperkeratosis, often occurring as idiopathic scrotal tumor and rarely as penile lesions. Twelve men, including our case of a 58-year-old white man, have been reported with angiokeratomas of the glans penis. The lesions typically present as asymptomatic dome-shaped papules ranging in size from 0. Read More
J Stroke Cerebrovasc Dis 2018 Mar 11;27(3):575-582. Epub 2017 Nov 11.
Academia de Medicina, Buenos Aires, Argentina.
Background: Fabry disease (FD) is an underdiagnosed cause of stroke in young adults, but the frequency of this association is largely unknown. We estimated the prevalence of FD in a nationwide cohort of young adults who had stroke and transient ischemic attack (TIA) in Argentina.
Methods: This was a prospective, multicenter study of stroke and FD in young adults (18-55 years) conducted in Argentina between 2011 and 2015. Read More
Eur J Dermatol 2017 10;27(5):556-557
Department of Dermatology, Chonbuk National University Medical School, Jeonju, South Korea, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, South Korea.
J Surg Case Rep 2017 Jul 7;2017(7):rjx133. Epub 2017 Jul 7.
Department Of General Surgery, PCMS & RC, Bhopal 462010, MP, India.
Eccrine angiokeratomatous hamartoma is a rare newly defined vascular lesion of the skin, the first case of which was reported in 2006 (Kanitakis J, Ly A, Claudy A. Eccrine angiokeratomatous hamartoma: a new variant of eccrine hamartoma with angiokeratoma. 2006; : S104-6). Read More
Circ Cardiovasc Genet 2017 Aug;10(4)
From the Faculty of Medicine, University of Iceland, Reykjavik, Iceland (B.A., R.P., R.A., G.T.G.); Division of Cardiology (B.A., R.D.), Department of Genetics (R.A.), Division of Nephrology (R.P.), and Department of Radiology (M.G.), Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland; Department of Cardiology, Haukeland University Hospital, Bergen, Norway (B.A.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (R.J.D., B.C., S.P.); Department of Genetics, Harvard Medical School, Boston, MA (P.T., M.A.B., J.G.S., C.E.S.); Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.A., U.N.); Division of Cardiology, Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (M.M., B.J.M.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (M.A.B., C.E.S.); Division of Cardiology, Emory University School of Medicine, Atlanta, GA (M.A.B.); Department of Medical Endocrinology, Rigshospitalet and University of Copenhagen, Denmark (C.V.M., U.F.-R.); Howard Hughes Medical Institute, Boston, MA (C.E.S.); and Department of Medicine, Akureyri Hospital, Iceland (G.T.G.).
Background: The screening of Icelandic patients clinically diagnosed with hypertrophic cardiomyopathy resulted in identification of 8 individuals from 2 families with X-linked Fabry disease (FD) caused by (α-galactosidase A gene) mutations encoding p.D322E (family A) or p.I232T (family B). Read More
Indian Dermatol Online J 2017 Jul-Aug;8(4):254-256
Department of Dermatology, Venereology and Leprosy, Post Graduate Institute of Medical Education and Research (PGIMER) and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Verrucous hemangioma is an uncommon congenital vascular malformation, which may clinically masquerade angiokeratoma, lymphangioma circumscriptum, or malignant melanoma. Differentiation is essential owing to varied therapeutic and prognostic implications. We present a rare case of multiple verrucous hemangiomas in a teenage girl who presented with multiple warty lesions over the dorsal aspect of the left foot since birth. Read More
J Cutan Pathol 2017 Oct 24;44(10):878-881. Epub 2017 Jul 24.
Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Acral angiokeratoma-like pseudolymphoma is a rare type of pseudolymphoma presenting as dark-red papules on the hand or foot. We describe a 59-year-old woman who presented with an unusual unilateral, clustered aggregate of scaly violaceous papules on the toe with an indolent course. Skin biopsy showed a prominent vascular proliferation associated with a dermal infiltrate of monoclonally rearranged T-follicular helper phenotype T-cells, in keeping with CD4+ small/medium T-cell lymphoproliferative disorder (SMPTC-LPD). Read More
J Cosmet Laser Ther 2017 Dec 30;19(8):459-464. Epub 2017 Jun 30.
b Department of Dermatology and Venereology , Comenius University , Bratislava , Slovak Republic.
Background: Angiokeratoma of Fordyce (AF) represents dark red or blue-black papules with a scaly surface located on scrotum, labia majora, and penis. Though usually asymptomatic, bleeding after mechanical trauma and sexual intercourse may occur. AF should be differentiated from malignant melanoma, angiosarcoma, and other pigmented lesions. Read More
J Am Acad Dermatol 2017 Sep 1;77(3):473-479. Epub 2017 Jun 1.
Department of Dermatology, University of California, San Francisco, California. Electronic address:
Background: Vascular malformations manifest with pain, bleeding, disability, and disfigurement in a subset of children. There are scant data available on the utility and tolerability of laser surgery for symptomatic or disfiguring non-port-wine stain vascular malformations in children.
Objective: The objective of this study was to determine the utility and tolerability of the 1064-nm long-pulsed neodymium:yttrium-aluminum-garnet (LP Nd:YAG) laser for treatment of symptomatic or disfiguring vascular malformations in children. Read More
Indian J Dermatol Venereol Leprol 2017 Jul-Aug;83(4):470-472
Department of Pathology, Marques de Valdecilla Universitary Hospital, University of Cantabria, IDIVAL, C/Avda. de Valdecilla s/n E-39008, Santander, Spain.
Dermatol Surg 2017 Nov;43(11):1313-1320
*University of Texas McGovern Medical School at Houston, Houston, Texas; †Department of Dermatology, University of Texas McGovern Medical School at Houston, Houston, Texas.
Background: Sodium tetradecyl sulfate (STS) is Food and Drug Administration approved for treatment of varicose veins, but numerous other off-label applications have been reported.
Objective: To describe the clinical uses of STS, as well as efficacy and adverse effects.
Methods: Review of studies searchable on PubMed from 1938 to 2016 describing clinical uses of STS to determine efficacy and adverse effects associated with various applications. Read More
Balkan Med J 2017 Apr;34(2):163-164
Department of Pediatrics, Adıyaman University School of Medicine, Adıyaman, Turkey.
Background: Angiokeratoma of fordyce occurring over on the vulva is a rare condition. Fordyce angiokeratoma is observed more frequently among men than women. In women, it is generally observed in later life, and appears as multiple dark purple papules, measuring 2-4 mm, on the vulva. Read More
J Dermatol 2017 Aug 13;44(8):e192-e193. Epub 2017 Apr 13.
Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan.
Pediatr Dermatol 2017 Mar;34(2):211-213
Division of Dermatology, Children's Mercy-Kansas City, Kansas City, Missouri.
The precise etiology and subtype of vessels constituting angiokeratomas is poorly understood. We sought to characterize the vessels by studying prospero-related homeobox gene-1 and D2-40 expression in 22 pediatric solitary angiokeratomas. Routine histologic examination demonstrated a mix of lymph-containing vessels and erythrocyte-filled small vessels. Read More
Medicine (Baltimore) 2017 Feb;96(6):e6063
aDepartment of Pediatrics, Asan Medical Center Children's Hospital bDivision of Cardiology, Cardiac Imaging Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Rationale: Angiokeratomas are the earliest manifestation of Fabry disease (FD), and the extent of their appearance is related to disease severity. Angiokeratomas are mostly found on cutaneous regions.
Patient Concerns, Diagnoses, Interventions, And Outcomes: Here we report an FD patient with widespread gastrointestinal angiokeratomas who developed life-threatening bleeding following anticoagulation for atrial fibrillation. Read More
Ann Dermatol Venereol 2017 Feb 16;144(2):137-146. Epub 2017 Jan 16.
Département de dermatologie, Hôpital Hôtel-Dieu de France, Faculté de médecine, Université Saint-Joseph, Beyrouth, Liban.
Fabry disease, also known as Anderson-Fabry disease or angiokeratoma corporis diffusum universale, is an X-linked recessive form of sphingolipidosis caused by total or partial deficiency of the lysosomal hydrolase, alpha-galactosidase A. From the youngest age, it results in a gradual ubiquitous build-up of glycosphingolipids that are not degraded by the missing enzyme. Cutaneous, neurological, nephrologic, cardiac, gastrointestinal, ophthalmological, respiratory, cochleovestibular and haematological involvement are responsible for increased mortality and significant impairment of quality of life in subjects affected by the disease. Read More
J Am Acad Dermatol 2017 Feb;76(2S1):S25-S27
Derma-Aid Centro Dermatógico de Alta Especialidad and Universidad Central del Ecuador, Quito, Ecuador. Electronic address:
J Am Acad Dermatol 2017 Feb;76(2S1):S16-S18
Department of Dermatology, Medical University of Graz, Graz, Austria.
J Pediatr Hematol Oncol 2017 07;39(5):407
Department of ENT and Head & Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Pillaiyarkuppam, Pondicherry, India.
A 9 year old male presented with diffuse swelling on his tongue since childhood associated with intermittent bleeding. On examination there was multiple, sessile, firm, pinkish, erythematous, shiny papules on both dorsal and ventral surface of the tongue. Angiokeratomas are vascular malformations of capillaries characterized clinically by asymptomatic, solitary or multiple, keratotic papules or plaques, and histologically by benign vascular ectasia of the papillary dermis. Read More
Kidney Blood Press Res 2016 23;41(6):1016-1024. Epub 2016 Dec 23.
Necmettin Erbakan University, Meram School of Medicine, Department of Internal Medicine, Division of Nephrology, Konya, Turkey.
Background/aims: Fabry disease is a treatable cause of chronic kidney disease (CKD) characterized by a genetic deficiency of α-galactosidase A. European Renal Best Practice (ERBP) recommends screening for Fabry disease in CKD patients. However, this is based on expert opinion and there are no reports of the prevalence of Fabry disease in stage 1-5 CKD. Read More