2,124 results match your criteria Angioimmunoblastic Lymphoma


Successful treatment with mogamulizumab of refractory/relapsed angioimmunoblastic T-cell lymphoma following autologous stem cell transplantation.

Leuk Lymphoma 2019 Feb 8:1-3. Epub 2019 Feb 8.

a Division of Hematology , Japanese Red Cross Society Wakayama Medical Center , Wakayama , Wakayama , Japan.

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http://dx.doi.org/10.1080/10428194.2018.1537489DOI Listing
February 2019

Immunoglobulinopathies in patients with angioimmunoblastic T-cell lymphoma.

Ter Arkh 2018 Aug;90(7):51-56

National Research Center for Hematology, Russian Federation, Moscow, Russia.

Aim: The aim of the study was to characterize quantitative and qualitative immunoglobulinopathies in patients with AITL at the onset of the disease.

Materials And Methods: 55 patients with newly diagnosed AITL were enrolled in the study, the male/female ratio was 30/25; median age was 61 (29-81) years. Diagnosis was based on standard WHO criteria. Read More

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http://dx.doi.org/10.26442/terarkh201890751-56DOI Listing
August 2018
1 Read

The role of autologous stem cell transplantation in patients with nodal peripheral T-cell lymphomas in first complete remission: Report from COMPLETE, a prospective, multicenter cohort study.

Cancer 2019 Jan 29. Epub 2019 Jan 29.

University of Washington Medical Center, Seattle, Washington.

Background: The role of autologous stem cell transplantation (ASCT) in the first complete remission (CR1) of peripheral T-cell lymphomas (PTCLs) is not well defined. This study analyzed the impact of ASCT on the clinical outcomes of patients with newly diagnosed PTCL in CR1.

Methods: Patients with newly diagnosed, histologically confirmed, aggressive PTCL were prospectively enrolled into the Comprehensive Oncology Measures for Peripheral T-Cell Lymphoma Treatment (COMPLETE) study, and those in CR1 were included in this analysis. Read More

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http://doi.wiley.com/10.1002/cncr.31861
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http://dx.doi.org/10.1002/cncr.31861DOI Listing
January 2019
6 Reads

Guillain Barré syndrome heralding the diagnosis of angioimmunoblastic T-cell lymphoma.

Leuk Lymphoma 2019 Jan 16:1-4. Epub 2019 Jan 16.

b Memorial Sloan Kettering Cancer Center , New York , NY , United States.

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https://www.tandfonline.com/doi/full/10.1080/10428194.2018.1
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http://dx.doi.org/10.1080/10428194.2018.1553299DOI Listing
January 2019
4 Reads

[T follicular helper/B/follicular dendritic cell localization is useful in the diagnosis of angioimmunoblastic T cell lymphoma].

Zhonghua Bing Li Xue Za Zhi 2019 Jan;48(1):40-42

Department of Hematology, the Second People's Hospital of Lianyungang, Lianyungang 222006, China.

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.01.009DOI Listing
January 2019
3 Reads

Allogeneic hematopoietic cell transplantation provides effective salvage despite refractory disease or failed prior autologous transplant in angioimmunoblastic T-cell lymphoma: a CIBMTR analysis.

J Hematol Oncol 2019 Jan 10;12(1). Epub 2019 Jan 10.

Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Suite C5500, 8701 W. Watertown Plank Rd, Milwaukee, WI, 53226, USA.

Background: There is a paucity of data on the role of allogeneic hematopoietic cell transplantation (allo-HCT) in patients with angioimmunoblastic T-cell lymphoma (AITL). Using the CIBMTR registry, we report here the outcomes of AITL patients undergoing an allo-HCT.

Methods: We evaluated 249 adult AITL patients who received their first allo-HCT during 2000-2016. Read More

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https://jhoonline.biomedcentral.com/articles/10.1186/s13045-
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http://dx.doi.org/10.1186/s13045-018-0696-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329157PMC
January 2019
5 Reads
4.812 Impact Factor

A case of AITL complicated by EBV-positive B cell and monoclonal plasma cell proliferation and effectively treated with lenalidomide.

Int J Hematol 2019 Jan 2. Epub 2019 Jan 2.

Department of Hematology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.

Angioimmunoblastic T-cell lymphoma (AITL) is a common subtype of peripheral T-cell lymphoma with an aggressive clinical course and poor prognosis after conventional chemotherapy, for which there is no current standard of care. We describe here an 87-year-old woman with AITL, whose clinical diagnosis was complicated by the presence of B immunoblasts positive for Epstein-Barr virus in the lymph nodes and monoclonal plasma cells in the bone marrow at initial presentation. Rebiopsy of the lymph node led to the correct diagnosis of AITL with concurrent smoldering plasma cell myeloma. Read More

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http://link.springer.com/10.1007/s12185-018-02587-6
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http://dx.doi.org/10.1007/s12185-018-02587-6DOI Listing
January 2019
2 Reads

Angioimmunoblastic T-Cell Lymphoma.

Cancer Treat Res 2019 ;176:99-126

Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York City, USA.

Angioimmunoblastic T-cell lymphoma (AITL) is one of the most common types of T-cell lymphoma, representing about 15-20% of cases of peripheral T-cell lymphoma (PTCL). It is characterized by a unique clinical presentation and distinct pathologic and molecular features. Classes of drugs particularly active in AITL are emerging; however, treatment of relapsed and refractory disease remains a challenge. Read More

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http://link.springer.com/10.1007/978-3-319-99716-2_5
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http://dx.doi.org/10.1007/978-3-319-99716-2_5DOI Listing
January 2019
6 Reads

Molecular and Genomic Landscape of Peripheral T-Cell Lymphoma.

Cancer Treat Res 2019 ;176:31-68

Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA.

Peripheral T-cell lymphoma (PTCL) is an uncommon group of lymphoma covering a diverse spectrum of entities. Little was known regarding the molecular and genomic landscapes of these diseases until recently but the knowledge is still quite spotty with many rarer types of PTCL remain largely unexplored. In this chapter, the recent findings from gene expression profiling (GEP) studies, including profiling data on microRNA, where available, will be presented with emphasis on the implication on molecular diagnosis, prognostication, and the identification of new entities (PTCL-GATA3 and PTCL-TBX21) in the PTCL-NOS group. Read More

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http://dx.doi.org/10.1007/978-3-319-99716-2_2DOI Listing
January 2019
1 Read

Interleukin-17-producing angioimmunoblastic T-cell lymphoma with Evans syndrome.

Br J Haematol 2019 Jan 28;184(2):122. Epub 2018 Dec 28.

Division of Haematology and Rheumatology, Faculty of Medicine, Kindai University, Osaka-Sayama, Japan.

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http://doi.wiley.com/10.1111/bjh.15733
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http://dx.doi.org/10.1111/bjh.15733DOI Listing
January 2019
5 Reads

Hematologic toxicity is rare in relapsed patients treated with belinostat: a systematic review of belinostat toxicity and safety in peripheral T-cell lymphomas.

Cancer Manag Res 2018 6;10:6731-6742. Epub 2018 Dec 6.

Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA,

Peripheral T-cell lymphomas (PTCLs) are an aggressive and diverse group of lymphomas with a T-cell origin. Most patients progress following initial treatment and require salvage therapy. The burden of symptoms is high due to its extra-nodal presentation, high rate of advanced disease, and associated cytopenias combined with its predilection for an elderly population. Read More

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https://www.dovepress.com/hematologic-toxicity-is-rare-in-re
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http://dx.doi.org/10.2147/CMAR.S149241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289206PMC
December 2018
7 Reads

Differentiation of angioimmunoblastic T-cell lymphoma from DRESS syndrome.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Division of Allergy, Asthma, and Clinical Immunology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2018.11.048DOI Listing
December 2018
1 Read

[Recent advances in pediatric non-Hodgkin lymphoma. Report on a retrospective single-center cohort and review of the literature].

Magy Onkol 2018 Dec 15;62(4):204-213. Epub 2018 Oct 15.

Gyermekgyógyászati Intézet, Gyermekhematológiai-onkológiai nem önálló Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar, Debrecen, Hungary.

Classification, staging and treatment response criteria of pediatric NHL have been revised. Long-term survival reaches ~90% at the expense of severe acute toxicities. The outcome of refractory and relapsed cases is poor. Read More

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December 2018
6 Reads

Methotrexate-Associated Lymphoproliferative Disorder with Diffuse Ground Glass Opacities.

Am J Respir Crit Care Med 2018 Dec 10. Epub 2018 Dec 10.

Hamamatsu University School of Medicine, 2nd Division, Department of Internal Medicine, Hamamatau, Japan.

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http://dx.doi.org/10.1164/rccm.201806-1115IMDOI Listing
December 2018
1 Read

IMMUNE RECOVERY UVEITIS-LIKE SYNDROME MIMICKING RECURRENT T-CELL LYMPHOMA AFTER AUTOLOGOUS BONE MARROW TRANSPLANT.

Retin Cases Brief Rep 2018 Nov 26. Epub 2018 Nov 26.

Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Purpose: To report the multimodal imaging findings of immune recovery uveitis mimicking recurrent T-cell lymphoma after autologous bone marrow transplant therapy.

Methods: A 71-year-old man presented with posterior uveitis 6 weeks after chemotherapy and autologous bone marrow transplant for angioimmunoblastic T-cell lymphoma. Multimodal imaging included fluorescein angiography, fundus autofluorescence, and optical coherence tomography. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000829DOI Listing
November 2018
4 Reads

Antidiuretic hormone- and interleukin-6-producing angioimmunoblastic T-cell lymphoma associated with syndrome of inappropriate antidiuretic hormone secretion.

Br J Haematol 2019 Jan 28;184(2):121. Epub 2018 Nov 28.

Division of Hematology and Rheumatology, Faculty of Medicine, Kindai University, Osakasayama-shi, Osaka, Japan.

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http://dx.doi.org/10.1111/bjh.15689DOI Listing
January 2019
1 Read

Bexarotene in Patients With Peripheral T-cell Lymphomas: Results of a Retrospective Study.

Clin Lymphoma Myeloma Leuk 2019 Feb 13;19(2):109-115. Epub 2018 Oct 13.

Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA. Electronic address:

Background: Peripheral T-cell lymphomas (PTCLs) are generally aggressive non-Hodgkin lymphomas that portend poor prognosis with currently available therapies. Bexarotene, a retinoic acid derivative, has efficacy in cutaneous T-cell lymphomas, but its activity in PTCL is unknown.

Patients And Methods: We conducted a retrospective, single-institution, review of off-label bexarotene therapy in patients with PTCL between 2005 and 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S21522650183047
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http://dx.doi.org/10.1016/j.clml.2018.10.001DOI Listing
February 2019
12 Reads

Risk factors and timing of autologous stem cell transplantation for patients with peripheral T-cell lymphoma.

Int J Hematol 2019 Feb 14;109(2):175-186. Epub 2018 Nov 14.

Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan.

High-dose chemotherapy with autologous stem cell transplantation (HDC-ASCT) is an option for patients with peripheral T-cell lymphoma (PTCL); however, neither prospective nor retrospective studies support proceeding with ASCT upfront, and the timing of HDC-ASCT remains controversial. We retrospectively analyzed the risk factors for outcomes of 570 patients with PTCL, including PTCL not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL), who received ASCT for frontline consolidation (n = 98 and 75, respectively) or alternative therapies after either relapse (n = 112 and 75) or primary induction failure (PIF; n = 127 and 83) between 2000 and 2015. Significant risk factors for overall survival (OS) after upfront ASCT were a ≥ 2 prognostic index for T-cell lymphoma (P < 0. Read More

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http://link.springer.com/10.1007/s12185-018-2560-x
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http://dx.doi.org/10.1007/s12185-018-2560-xDOI Listing
February 2019
5 Reads

Angioimmunoblastic T-cell lymphoma mimicking diffuse large B-cell lymphoma.

Cutis 2018 Sep;102(3):179-182

Department of Dermatology, Saint Joseph Mercy Hospital, Ann Arbor, Michigan, USA.

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive form of peripheral T-cell lymphoma that is characterized by lymphadenopathy, night sweats, fever, weight loss, and autoimmune phenomena. Cutaneous manifestations are present in up to 50% of cases, but few cases are reported in the dermatologic literature. We present a case of AITL that manifested in the skin. Read More

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September 2018
7 Reads

Cutaneous localization of angioimmunoblastic T-cell lymphoma may masquerade as B-cell lymphoma or classical Hodgkin lymphoma: A histologic diagnostic pitfall.

J Cutan Pathol 2019 Feb 10;46(2):102-110. Epub 2018 Dec 10.

Département de Biopathologie, CHU Montpellier, Hôpital Gui De Chauliac, Montpellier, France.

Background: We report the cases of three patients presenting skin lesions whose biopsies showed nodular polymorphic infiltrates consisting of lymphocytes, plasma cells, histiocytes, eosinophils, B blasts, and Hodgkin Reed-Sternberg (HRS)-like cells. Two of them were initially diagnosed as classical Hodgkin lymphoma (cHL), on the other hand, the last one as a B-cell lymphoma. All patients have been treated for angioimmunoblastic T-cell lymphoma (AITL). Read More

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http://dx.doi.org/10.1111/cup.13382DOI Listing
February 2019
6 Reads

A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer.

Cancer 2019 Jan 17;125(1):99-108. Epub 2018 Oct 17.

Early Phase Trials Unit, Churchill Hospital, University of Oxford, Oxford, United Kingdom.

Background: In the current study, the authors sought to determine the maximum tolerated dose (MTD) of the novel class 1 selective histone deacetylase inhibitor CXD101 in a dose escalation study in patients with advanced solid tumors or recurrent/refractory lymphoma.

Methods: The authors escalated the dose of CXD101 from 1 mg twice daily orally for 5 days in a 21-day cycle (3+3 design).

Results: A total of 39 patients were enrolled, 36 of whom received CXD101. Read More

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http://dx.doi.org/10.1002/cncr.31791DOI Listing
January 2019
8 Reads

Profiles of serum cytokines and their clinical implications in patients with peripheral T-cell lymphoma.

Cytokine 2019 Jan 14;113:371-379. Epub 2018 Oct 14.

Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of Korea; Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

To better predict the outcomes of patients with peripheral T-cell lymphoma (PTCL), we measured the levels of various cytokines in serum samples from patients with PTCL and analyzed their clinical outcomes. We measured 34 cytokines in samples from 121 PTCL patients (55 PTCL-not otherwise specified (NOS), 44 angioimmunoblastic T-cell lymphoma (AITL), and 22 ALK anaplastic large cell lymphoma) at diagnosis. Their impact on clinical outcomes, including overall survival and complete response rate, were analyzed with other clinical variables. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.10.009DOI Listing
January 2019

Noncaseating suppurative granulomatous lymphadenitis in adult onset Still's disease - a diagnostic dilemma in a tuberculosis-endemic region: a case report.

J Med Case Rep 2018 Oct 15;12(1):299. Epub 2018 Oct 15.

Sri Jayewardenepura General Hospital and Post-graduate Training Institute, Sri Jayawardenepura Kotte, Western Province, Sri Lanka.

Background: Lymphadenopathy is not an uncommon presentation of adult onset Still's disease: it is present in up to two thirds of patients with adult onset Still's disease. The characteristic appearance of lymphadenopathy is described as intense, paracortical immunoblastic hyperplasia. Changes in light microscopy may resemble lymphoma, but immunohistochemistry reveals a benign polyclonal B cell hyperplasia. Read More

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http://dx.doi.org/10.1186/s13256-018-1816-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192002PMC
October 2018
3 Reads

Intestinal T-cell and NK/T-cell lymphomas: A clinicopathological study of 27 Chinese patients.

Ann Diagn Pathol 2018 Dec 9;37:107-117. Epub 2018 Oct 9.

Department of Pathology, Xinqiao Hospital, Third Military Medical University, Chongqing, China. Electronic address:

Background: Intestinal T-cell and NK/T- cell lymphomas are rare and aggressive. The diagnosis is quite difficult, especial in biopsy specimens. This study investigates the clinicopathological features of intestinal T-cell and NK/T-cell lymphomas to aid their differential diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183013
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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.004DOI Listing
December 2018
11 Reads
1.110 Impact Factor

Cutaneous angioimmunoblastic T-cell lymphoma: Epstein-Barr Virus positivity and its effects on clinicopathological features.

J Am Acad Dermatol 2018 Sep 18. Epub 2018 Sep 18.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:

Background: Epstein-Barr virus (EBV) positivity frequently presents in patients with nodal angioimmunoblastic T-cell lymphoma (AITL). However, the presence of EBV in skin lesions and its clinicopathological significance have not been evaluated.

Objective: To analyze the clinical and histopathological features of cutaneous AITL and evaluate EBV-positivity in skin tissue and its effects on clinicopathological features of AITL. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.08.053DOI Listing
September 2018
4 Reads

Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme-like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report.

Exp Ther Med 2018 Sep 6;16(3):2060-2065. Epub 2018 Jul 6.

Department of Hematology and Oncology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, P.R. China.

Angioimmunoblastic T cell lymphoma (AITL)-associated hemophagocytic lymphohistiocytosis (HLH) rarely occurs with annular erythema multiforme-like rashes. The present case report describes a patient who was misdiagnosed with erythema multiforme at an early stage of the disease due to annular erythema multiforme-like eruptions. However, antihistamine treatment was ineffective. Read More

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http://dx.doi.org/10.3892/etm.2018.6420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122190PMC
September 2018
3 Reads

Peripheral T-Cell Lymphomas: Incorporating New Developments in Diagnostics, Prognostication, and Treatment Into Clinical Practice-PART 2: ENKTL, EATL, Indolent T-Cell LDP of the GI Tract, ATLL, and Hepatosplenic T-Cell Lymphoma.

Oncology (Williston Park) 2018 08 15;32(8):e83-e89. Epub 2018 Aug 15.

The World Health Organization classification for peripheral T-cell lymphomas (PTCLs) continues to evolve based on genetic and clinical distinctions of each entity. In Part 1, an overview was provided of PTCL not otherwise specified, follicular T-cell lymphoma, angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma (ALCL), and breast implant-associated ALCL. In Part 2, this review is extended to extranodal natural killer (NK)/T-cell lymphoma, enteropathy-associated T-cell lymphoma, indolent T-cell lymphoproliferative disorder of the gastrointestinal tract, adult T-cell leukemia/lymphoma, and hepatosplenic T-cell lymphoma. Read More

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August 2018
3 Reads

B2 microglobulin is a novel prognostic marker of Angioimmunoblastic T-cell lymphoma.

Sci Rep 2018 Aug 27;8(1):12907. Epub 2018 Aug 27.

Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

The aim of the present study was to analyze features and explore parameters that can help to predict prognosis for angioimmunoblastic T-cell lymphoma (AITL). A total of 117 patients with AITL were retrospectively analyzed. Multivariate analysis showed that β2 microglobulin (β2-M) ≥4. Read More

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http://dx.doi.org/10.1038/s41598-018-31212-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110724PMC

Angioimmunoblastic T-cell lymphoma presenting with extensive marrow plasmacytosis and hypergammaglobulinaemia: a diagnostic challenge.

Pathology 2018 10 22;50(6):665-668. Epub 2018 Aug 22.

Department of Medical Oncology and Hematology, Medanta - The Medicity Hospital, Gurgaon, India.

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http://dx.doi.org/10.1016/j.pathol.2018.03.014DOI Listing
October 2018
2.190 Impact Factor

Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma.

Fam Cancer 2019 01;18(1):113-119

Department of Medical and Clinical Genetics, Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma with a poor prognosis: the 5-year survival rate is approximately 30%. Somatic driver mutations have been found in TET2, IDH2, DNMT3A, RHOA, FYN, PLCG1, and CD28, whereas germline susceptibility to AITL has to our knowledge not been studied. The homogenous Finnish population is well suited for studies on genetic predisposition. Read More

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http://dx.doi.org/10.1007/s10689-018-0099-xDOI Listing
January 2019
1 Read

Chylous ascites, anti-interferon-gamma autoantibody, and angioimmunoblastic T-cell lymphoma: a rare but intriguing connection over Mycobacterium avium.

Med Microbiol Immunol 2019 Feb 6;208(1):33-37. Epub 2018 Aug 6.

Department of Hematology, Shiga University of Medical Science, Otsu, Shiga, Japan.

We report a case of non-AIDS (acquired immunodeficiency syndrome), non-CAPD (Continuous Ambulatory Peritoneal Dialysis), non-cirrhotic, Mycobacterium avium peritonitis, which is a rare form of mycobacterial infection. A 66-year-old Japanese man who had been treated previously for angioimmunoblastic T-cell lymphoma (AITL), had developed disseminated M. avium infection. Read More

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http://dx.doi.org/10.1007/s00430-018-0555-0DOI Listing
February 2019
4 Reads

Peripheral T cell lymphoma: Clinico-pathological characteristics & outcome from a tertiary care centre in south India.

Indian J Med Res 2018 05;147(5):464-470

Department of Clinical Hematology, Christian Medical College & Hospital, Vellore, India.

Background & Objectives: Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin's lymphomas (NHLs), with universally poor outcome. This study was undertaken to provide data on demographics and outcomes of patients with PTCL who underwent treatment in a single tertiary care centre in southern India.

Methods: Retrospective study was done on all patients (age ≥18 yr) diagnosed with PTCL from January 2007 to December 2012. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_1108_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094517PMC
May 2018
3 Reads
1 Citation
1.661 Impact Factor

Peripheral T-Cell Lymphomas: Incorporating New Developments in Diagnostics, Prognostication, and Treatment Into Clinical Practice-PART 1: PTCL-NOS, FTCL, AITL, ALCL.

Oncology (Williston Park) 2018 07 15;32(7):e74-e82. Epub 2018 Jul 15.

Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of diseases, with low incidence and unique epidemiology and pathobiology; they are usually clinically aggressive, with poor outcomes. There have been significant advances in our understanding of the molecular and signaling alterations seen in these malignancies. These observations have led to novel therapeutic strategies that have had a meaningful impact on outcomes. Read More

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July 2018
5 Reads

EBV-Related Diffuse Large B-Cell Lymphoma in a Patient with Angioimmunoblastic T-Cell Lymphoma

Turk J Haematol 2019 02 1;36(1):57-59. Epub 2018 Aug 1.

Hacettepe University Faculty of Medicine, Division of Hematology, Ankara, Turkey

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http://dx.doi.org/10.4274/tjh.galenos.2018.2018.0023DOI Listing
February 2019
8 Reads

FROM THE PERSISTENT EPSTEIN-BARR VIRUS INFECTION TO ANGIOIMMUNOBASTIC T-CELL LYMPHOMA - DRAMATIC CONVERGENCE. ANALYSIS OF THE CLINICAL CASE.

Georgian Med News 2018 Jun(279):122-131

National Pirogov Memorial Medical University, Propedeutic Department of Internal Medicine; Department of Infection Diseases, Vinnytsya; Podilskiy Regional Oncological Center, Cytological Laboratory, Ukraine.

The problem of timely diagnosis and effective treatment of EBD-associated lymphoproliferative diseases is associated with a large variety of morphological and immunological manifestations, which require a powerful, highly specific immunohistochemical and molecular genetic research methods for the correct assessment. The article elucidates current information about the pathogenesis of oncogenic EBV infection, the main clinical forms of associated lymphoproliferative processes, their main diagnostic criteria. The given clinical case of angioimmunoblastic T cell lymphoma clearly demonstrates the complexity of the diagnostic process, underestimation of informativity and the importance of molecular genetic research, which led to the rejection of chemotherapeutic treatment, the rapid progression of the terminal stage of lymphoproliferative disease with the development of polyorganic failure and lifetime destruction, necrosis of the structural components of the tumor, as a result of which during the autopsy of morphological signs of lymphoma was not detected. Read More

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June 2018
5 Reads

New insights in the pathogenesis of T-cell lymphomas.

Curr Opin Oncol 2018 Sep;30(5):277-284

Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Purpose Of Review: Peripheral T-cell lymphomas (PTCLs) represent diverse and aggressive malignancies, with few recent therapeutic improvements. Recent high-throughput genomic studies have revealed the complex mutational landscape of these rare diseases. These novel findings provide the grounds to a more comprehensive classification of these diseases, reflected in the 2017 WHO classification. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000474DOI Listing
September 2018
4 Reads

Hematological malignancies mimicking rheumatic syndromes: case series and review of the literature.

Rheumatol Int 2018 Sep 18;38(9):1743-1749. Epub 2018 Jul 18.

Department of Internal Medicine F, The Chaim Sheba Medical Center, Tel Hahsomer, Israel.

It is well established that some rheumatic syndromes (RS) are associated with several hematological malignancies. We aimed to describe the clinical course of patients with hematological malignancies mimicking RS. We studied a series of four patients presenting with apparent RS who were eventually diagnosed with hematological malignancies, and reviewed the relevant literature. Read More

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http://dx.doi.org/10.1007/s00296-018-4107-0DOI Listing
September 2018
2 Reads
1 Citation
1.630 Impact Factor

Outcome and Prospective Factor Analysis of High-dose Therapy Combined with Autologous Peripheral Blood Stem Cell Transplantation in Patients with Peripheral T-cell Lymphomas.

Int J Med Sci 2018 4;15(9):867-874. Epub 2018 Jun 4.

Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute.

For peripheral T-cell lymphomas (PTCLs) patients, high-dose therapy combined with autologous peripheral blood stem cell transplantation (HDT/ASCT) has been an alternative treatment option, due to the lack of efficacy from conventional chemotherapy. While not all PTCLs could have benefit in survival from HDT/ASCT. The aim of this study was to evaluate the value of high-dose therapy combined with autologous peripheral blood stem cell transplantation (HDT/ASCT) in Chinese patients with Peripheral T-cell Lymphomas (PTCLs), in order to determine the cohort most suitable to receive HDT/ASCT. Read More

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http://dx.doi.org/10.7150/ijms.23067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036090PMC
January 2019
15 Reads
2.000 Impact Factor

Meningeal cryptococcosis in a patient with angioimmunoblastic lymphoma treated with alemtuzumab.

Med Clin (Barc) 2019 Feb 9;152(4):e19-e20. Epub 2018 Jul 9.

Servicio de Hematología Clínica, ICO-Girona, Hospital Universitario Dr. Josep Trueta, Girona, España.

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http://dx.doi.org/10.1016/j.medcli.2018.05.030DOI Listing
February 2019
6 Reads

Methotrexate-associated lymphoproliferative disorders with angioimmunoblastic T-cell lymphoma-like features accompanied by gamma-heavy chain disease in a patient with rheumatoid arthritis.

Pathol Int 2018 Jul 10. Epub 2018 Jul 10.

Department of Hematology, Iizuka Hospital, Iizuka, Japan.

Although gamma heavy chain disease (γ-HCD) lesions occasionally morphologically resemble angioimmunoblastic T-cell lymphoma (AITL), no association has been described in detail due to the rarity of the disease. In this report, we present a rare manifestation of methotrexate (MTX)-associated lymphoproliferative disorders (LPDs) with AITL-like features accompanied by γ-HCD in a 75-year-old man with rheumatoid arthritis (RA). A biopsy specimen was evaluated using immunohistochemistry, clonal analyses of immunoglobulin V and T-cell receptor γ gene rearrangements by polymerase chain reaction, and Sanger sequencing for confirmation of the structure of deleted γ-HCD clones. Read More

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http://doi.wiley.com/10.1111/pin.12703
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http://dx.doi.org/10.1111/pin.12703DOI Listing
July 2018
10 Reads

Multiple Ways to Detect IDH2 Mutations in Angioimmunoblastic T-Cell Lymphoma from Immunohistochemistry to Next-Generation Sequencing.

J Mol Diagn 2018 Sep 5;20(5):677-685. Epub 2018 Jul 5.

INSERM U955 Équipe 9, Institut Mondor de Recherche Biomédicale, Créteil, France; Université Paris Est, Créteil, France; Département de Pathologie, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil, France.

Angioimmunoblastic T-cell lymphoma (AITL) is a peripheral T-cell lymphoma associated with chemoresistance and a poor prognosis. Various nonsynonymous mutations in the R172 residue of IDH2 are present in 20% to 30% of AITL patients. In addition to their diagnostic value, these mutations are potentially targetable, especially by isocitrate dehydrogenase (IDH) 2 inhibitor, and therefore their identification in a routine setting is clinically relevant. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2018.05.012DOI Listing
September 2018
8 Reads

Human Herpes Virus 6 (HHV-6)-associated Lymphadenitis: Pitfalls in Diagnosis in Benign and Malignant Settings.

Am J Surg Pathol 2018 Oct;42(10):1402-1408

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Human herpes virus 6 (HHV-6) is a member of the β-herpesvirinae subfamily. Most people acquire HHV-6 primary infection early in life and reactivation may occur, most often in immunocompromised individuals, leading to various clinical manifestations. HHV-6 infected cells may be identified in lymph nodes in both reactive and neoplastic conditions. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133726PMC
October 2018
13 Reads

[Systemic lupus erythematosus with marked eosinophilia and clinical features mimicking TAFRO syndrome].

Rinsho Ketsueki 2018 ;59(6):688-694

Department of Hematology, Suita Municipal Hospital.

A 76-year-old woman was referred to our hospital because of fever, hemorrhagic skin lesion with pruritus, and severe thrombocytopenia. Anemia; marked eosinophilia; and elevated ALP, CRP, and soluble IL-2 receptor levels were observed on admission. Both anti-nuclear antibody and Coombs tests were positive. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/6/59_688/_a
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http://dx.doi.org/10.11406/rinketsu.59.688DOI Listing
January 2018
9 Reads

Secondary Cutaneous Epstein-Barr Virus-associated Diffuse Large B-cell Lymphoma with Hodgkin/Reed-Sternberg-like Cells in a Patient with Angioimmunoblastic T-cell Lymphoma.

Acta Derm Venereol 2018 Nov;98(10):981-982

Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.

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http://dx.doi.org/10.2340/00015555-2996DOI Listing
November 2018
6 Reads

Molecular Insights Into Pathogenesis of Peripheral T Cell Lymphoma: a Review.

Curr Hematol Malig Rep 2018 08;13(4):318-328

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-6842, USA.

Purpose Of Review: Peripheral T cell lymphoma (PTCL) is a heterogeneous group of lymphoproliferative neoplasms, with at least 29 distinct entities described in current WHO classification. Using present diagnostic approaches, more than a third of PTCL cases cannot be classified, hence designated as PTCL-not otherwise specified (PTCL-NOS). Herein, we summarize the current genomic findings and their role in the molecular pathogenesis in different PTCL entities. Read More

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http://dx.doi.org/10.1007/s11899-018-0460-zDOI Listing
August 2018
14 Reads

Angioimmunoblastic T-cell lymphoma: a prognostic model from a retrospective study.

Leuk Lymphoma 2018 Dec 18;59(12):2911-2916. Epub 2018 Jun 18.

a Department of Medical Oncology, Sun Yat-sen University Cancer Center , State Key Laboratory of Oncology in Southern China, and Collaborative Innovation Center of Cancer Medicine , Guangzhou , China.

Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma with unique clinical and pathological features. This study aim to design a prognostic model specifically for AITL, providing risk stratification in affected patients. A total of 115 newly diagnosed AITL patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.1080/10428194.2018.1459610DOI Listing
December 2018
5 Reads

TP53 mutations in peripheral mature T and NK cell lymphomas: a whole-exome sequencing study with correlation to p53 expression.

Hum Pathol 2018 Oct 6;80:145-151. Epub 2018 Jun 6.

Department of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan; Department of Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833031, Taiwan; Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung 83102, Taiwan. Electronic address:

Peripheral mature T and NK cell lymphomas consist of a heterogeneous group of neoplasms with cytogenetic and molecular diversities. TP53 mutation is involved in the events of tumorigenesis and present in a variety of cancer subtypes. However, TP53 mutation in peripheral mature T and NK cell lymphomas has not been extensively investigated. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.05.026DOI Listing
October 2018
15 Reads