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    Autologous stem cell transplantation as frontline strategy for peripheral T-cell lymphoma: A single-centre experience.
    J Int Med Res 2017 Feb 12;45(1):290-302. Epub 2017 Jan 12.
    Peking Union Medical College Hospital (PUMCH), Beijing, China.
    Objective To determine the efficacy and prognosis of autologous hematopoietic stem cell transplantation (ASCT) as frontline treatment for peripheral T cell lymphoma (PTCL). Methods Clinical data from 46 PTCL patients who achieved complete (CR) or partial remission (PR) after ASCT from October 1996 to July 2014 were analysed retrospectively. Results Median patient age was 32 (range: 15-68) years. Read More

    Analysis of Peripheral T-cell Lymphoma Diagnostic Workup in the United States.
    Clin Lymphoma Myeloma Leuk 2017 Jan 10. Epub 2017 Jan 10.
    Department of Medical Oncology, Yale University, New Haven, CT.
    Background: With increased understanding of the unique entities, subtype-specific approaches for peripheral T-cell lymphoma (PTCL) are emerging, and more precise diagnoses are becoming increasingly important. PATIENTS AND METHODS: We analyzed the approach to the histopathologic diagnosis of PTCL using data from the comprehensive oncology measures of peripheral T-cell lymphoma (COMPLETE) study. The COMPLETE trial is a large prospective cohort study of patients with newly diagnosed PTCL in the United States. Read More

    Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma.
    Case Rep Hematol 2017 18;2017:9601094. Epub 2017 Jan 18.
    Department of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    An elderly woman presented with generalized lymphadenopathy, several systemic symptoms, and splenomegaly. An inguinal lymph node excision revealed a compound picture. One aspect of the lymph node morphology, including cells with follicular T-helper cell phenotype, was most consistent with angioimmunoblastic T-cell lymphoma. Read More

    Inappropriate costimulation and aberrant DNA methylation as therapeutic targets in angioimmunoblastic T-cell lymphoma.
    Biomark Res 2017 8;5. Epub 2017 Feb 8.
    grid.412966.eDepartment of Internal Medicine, Division of Hematology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
    Angioimmunoblastic T-cell lymphoma (AITL) is one of the most common subtypes of peripheral T-cell lymphoma. Advances in understanding the mutational landscape of AITL have not resulted in improved prognosis nor consensus regarding optimal first-line and second-line treatment. The recently proposed multistep tumorigenesis model for AITL provides a theoretical framework of AITL oncogenesis. Read More

    Angioimmunoblastic T-Cell Lymphoma with Polyarthritis Resembling Rheumatoid Arthritis.
    Clin Med Res 2016 Dec;14(3-4):159-162
    Department of Pathology, Marshfield Clinic, Marshfield Wisconsin USA.
    Angioimmunoblastic T-cell lymphoma (AITL) is a rare subtype of peripheral T-cell lymphoma (PTCL). AITL typically presents with lymphadenopathy, fever, rash, hepatosplenomegaly, and rarely polyarthritis. We report the case of a 50-year-old female who presented with lymphadenopathy, rash, and symmetric polyarthritis. Read More

    Identification of cell-type-specific mutations in nodal T-cell lymphomas.
    Blood Cancer J 2017 Jan 6;7(1):e516. Epub 2017 Jan 6.
    Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
    Recent genetic analysis has identified frequent mutations in ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 2 (IDH2) and ras homolog family member A (RHOA) in nodal T-cell lymphomas, including angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified. We examined the distribution of mutations in these subtypes of mature T-/natural killer cell neoplasms to determine their clonal architecture. Targeted sequencing was performed for 71 genes in tumor-derived DNA of 87 cases. Read More

    Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling.
    Oncotarget 2017 Jan 27. Epub 2017 Jan 27.
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK.
    Angioimmunoblastic T cell lymphoma (AITL) originates from follicular helper T-cells and is characterised by a polymorphic infiltrate with the neoplastic T-cells forming small clusters around the follicle and high endothelial venules. Despite the recent advances in its phenotypic characterisation, the genetics and molecular mechanisms underlying AITL are not fully understood. In the present study, we performed whole exome sequencing in 9 cases of AITL from Taiwan (n = 6) and U. Read More

    Chidamide in the treatment of peripheral T-cell lymphoma.
    Onco Targets Ther 2017 12;10:347-352. Epub 2017 Jan 12.
    Department of Medicine, Queen Mary Hospital, Hong Kong, People's Republic of China.
    Mature T-cell lymphomas are aggressive malignancies. Treatment outcome is poor with conventional chemotherapy. They are about twice as common in Asia as compared with other non-Asian countries. Read More

    Lymphoma classification update: T-cell lymphomas, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms.
    Expert Rev Hematol 2017 Jan 29:1-11. Epub 2017 Jan 29.
    a Department of Laboratory Medicine and Pathology , Mayo Clinic , Rochester , MN , USA.
    Introduction: Lymphomas are classified based on the normal counterpart, or cell of origin, from which they arise. Because lymphocytes have physiologic immune functions that vary both by lineage and by stage of differentiation, the classification of lymphomas arising from these normal lymphoid populations is complex. Recent genomic data have contributed additional depth to this complexity. Read More

    [A Case of Angioimmunoblastic T-Cell Lymphoma Merged with Colorectal Cancer That We Were Able to Resect after a Chemotherapy Response].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1620-1622
    Dept. of Surgery, Minoh City Hospital.
    The patient was 77-year-old man. He visited our hospital with the chief complaint of an abdominal mass in March 2015. We diagnosed the patient with transverse colon cancer and he was suspected of having malignant lymphoma. Read More

    Clinicopathological Study of 30 Cases of Peripheral T-cell Lymphoma with Hodgkin and Reed-Sternberg-like B-cells from Japan.
    Am J Surg Pathol 2017 Jan 25. Epub 2017 Jan 25.
    *Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan †Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt ‡Department of Surgical Pathology, Aichi Medical University Hospital, Nagakute, Japan §Department of Clinical Laboratory, Nagano Prefectural Suzaka Hospital, Nagano, Japan.
    The presence of Hodgkin and Reed-Sternberg (HRS)-like B-cells in peripheral T-cell lymphoma (PTCL) is rare and its clinicopathological features still remain unclear. Here, we describe 30 cases of PTCL with HRS-like B-cells from Japan. Twenty-three cases (77%) presented evidence of follicular T-helper phenotype (TFH) derivation: 12 were angioimmunoblastic T-cell lymphoma and 11 PTCL with TFH phenotype (PTCL-TFH). Read More


    Angioimmunoblastic T-cell lymphoma: the many faced lymphoma.
    Blood 2017 Jan 23. Epub 2017 Jan 23.
    University of Nebraska Medical Center, Omaha, NE, United States
    Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon subtype of mature peripheral T-cell lymphoma (PTCL). The history of AITL is much longer and deeper than the literature would suggest given the many names that has preceded it. Advanced stage disease is common with uncharacteristic laboratory and autoimmune findings that often slow or mask the diagnosis. Read More

    Langerhans cell histiocytosis associated with lymphoma: an incidental finding that is not associated with BRAF or MAP2K1 mutations.
    Mod Pathol 2017 Jan 13. Epub 2017 Jan 13.
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Langerhans cell histiocytosis is characterized by a localized or systemic proliferation of Langerhans cells. BRAF mutations have been reported in 40-70% of cases and MAP2K1 mutations have been found in BRAF-negative cases, supporting that Langerhans cell histiocytosis is a true neoplasm, at least in mutated cases. In a small subset of patients, Langerhans cell histiocytosis is detected incidentally in a biopsy involved by lymphoma. Read More


    Recombinant human endostatin in combination with CHOP regimen for peripheral T cell lymphoma.
    Onco Targets Ther 2017 22;10:145-151. Epub 2016 Dec 22.
    Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
    Peripheral T cell lymphoma (PTCL) has a poor prognosis. Overexpression of vascular endothelial growth factor (VEGF) might contribute to the poor prognosis of PTCL and could be the target of novel therapy. The efficacy and safety of recombinant human endostatin (Endostar) in combination with cyclophosphamide, doxorubicin, vincristine and prednisone (ECHOP) have been explored in 15 PTCL patients. Read More

    Angioimmunoblastic T-cell Lymphoma Associated with IgA Nephropathy.
    Intern Med 2017;56(1):85-89. Epub 2017 Jan 1.
    Department of Internal Medicine, Nagano Chuo Hospital, Japan.
    Few cases of IgA nephropathy with angioimmunoblastic T-cell lymphoma (AITL) have been reported. We herein present the case of a 79-year-old Japanese man with AITL and IgA nephropathy. The patient presented with generalized edema, fatigue, and fever. Read More

    Cutaneous Presentation of Angioimmunoblastic T-Cell Lymphoma: A Harbinger of Poor Prognosis?
    Skinmed 2016 1;14(6):469-471. Epub 2016 Dec 1.
    Singapore General Hospital, Singapore.
    A 62-year-old woman presented with a 2-year history of extensive, pruritic dermatosis over her face, trunk, and limbs. She was initially treated for psoriasis with methotrexate 5 mg twice weekly and topical clobetasol cream; however, her condition worsened, and she was admitted for generalized exfoliative dermatitis. Examination showed generalized erythema and scaling affecting her face (Figure 1A), chest (Figure 1B), back, and limbs. Read More

    Lymphoma in Taiwan: Review of 1347 neoplasms from a single institution according to the 2016 Revision of the World Health Organization Classification.
    J Formos Med Assoc 2016 Dec 18. Epub 2016 Dec 18.
    Department of Radiology, Chi-Mei Medical Center, Tainan, Taiwan.
    Background: Lymphoid neoplasms are heterogeneous and types of lymphoma vary in different geographic regions. In this study, we aimed at classifying the lymphoid neoplasms at our institution in Taiwan and to compare the relative frequency of various types of lymphoma in different countries.

    Methods: We retrospectively searched the files of patients diagnosed with lymphoma at our institution from 2000 to 2015 based on the 2016 Revision of the World Health Organization classification. Read More

    [Comparison of allogeneic or autologous hematopoietic stem cell transplant for high-risk peripheral T cell lymphomas].
    Zhonghua Xue Ye Xue Za Zhi 2016 Nov;37(11):952-956
    Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Key Laboratory of Thrombosis and Hemstasis of Ministry of Health, Collaborative Innovation Center of Hematology, Suzhou 215006, China.
    Objective: To evaluate the efficacy of auto-HSCT and allo-HSCT in the treatment of high risk peripheral T cell lymphoma (PTCL). Methods: From July 2007 to July 2014, 60 cases of high risk PTCL were analyzed retrospectively. Results: All 60 patients were at high risk group (carried with IPI≥3), with a median age of 31 (12-58) years old. Read More

    The survival outcome of patients with relapsed/refractory peripheral T-cell lymphoma-not otherwise specified and angioimmunoblastic T-cell lymphoma.
    Br J Haematol 2017 Mar 16;176(5):750-758. Epub 2016 Dec 16.
    Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Survival outcome of patients with peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL) who experience disease progression/relapse remains very poor. A total of 321 patients, newly diagnosed with PTCL-NOS (n = 180) or AITL (n = 141) between 1999 and 2015, were analysed. Failure-free survival (FFS) and overall survival (OS) were calculated from the time of first disease progression (FFS1, OS1), from second disease progression (FFS2, OS2) and from third progression (FFS3, OS3). Read More

    How I manage peripheral T-cell lymphoma, not otherwise specified and angioimmunoblastic T-cell lymphoma: current practice and a glimpse into the future.
    Br J Haematol 2016 Dec 16. Epub 2016 Dec 16.
    Institute of Pathology, University Hospital Lausanne and University of Lausanne, Switzerland.
    Peripheral T-cell lymphoma (PTCL), not otherwise specified (NOS) and angioimmunoblastic T-cell lymphoma (AITL) are the most frequent of more than 20 mature PTCL entities featuring a broad spectrum of morphological, immunophenotypic, molecular and clinical characteristics. Unfortunately, recent progress in understanding the (epi)genetic background of PTCL has not been met with similar advances in treatment. Thus, CHO(E)P [cyclophosphamide, doxorubicin, vincristine, and prednisone (plus etoposide)] remains standard first-line therapy. Read More

    The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.
    Proc Natl Acad Sci U S A 2016 Dec 12;113(52):15084-15089. Epub 2016 Dec 12.
    The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada;
    Oncogenic isocitrate dehydrogenase (IDH)1 and IDH2 mutations at three hotspot arginine residues cause an enzymatic gain of function that leads to the production and accumulation of the metabolite 2-hydroxyglutarate (2HG), which contributes to the development of a number of malignancies. In the hematopoietic system, mutations in IDH1 at arginine (R) 132 and in IDH2 at R140 and R172 are commonly observed in acute myeloid leukemia, and elevated 2HG is observed in cells and serum. However, in angioimmunoblastic T-cell lymphoma (AITL), mutations are almost exclusively restricted to IDH2 R172, and levels of 2HG have not been comprehensively measured. Read More

    BCL6 locus is hypermethylated in angioimmunoblastic T-cell lymphoma.
    Int J Hematol 2016 Dec 5. Epub 2016 Dec 5.
    Department of Hematology, Comprehensive Human, Biosciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan.
    BCL6, a master transcription factor for differentiation of follicular helper T (TFH) cells, is highly expressed in angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphomas (PTCL) containing tumor cells with TFH features. TET2, encoding an epigenetic regulator, is frequently mutated in AITL/PTCL. We previously reported that Tet2 knockdown mice developed T-cell lymphomas with TFH features. Read More

    T cell-rich lymphoid infiltrates with large B cells: a review of key entities and diagnostic approach.
    J Clin Pathol 2017 Mar 28;70(3):187-201. Epub 2016 Nov 28.
    Haematological Malignancy Diagnostic Service, Centre for Molecular Pathology, The Royal Marsden Hospital, Sutton, London, UK.
    Accurate diagnostic interpretation of a lymphoid population composed predominantly of small T cells, together with smaller numbers of large B cells, with or without a nodular architecture, is a common problem faced by the histopathologist. The differential diagnosis of this histological pattern is wide, ranging from reactive conditions such as drug reactions and viral infections, through borderline entities such as immunodeficiency-related lymphoproliferative disorders to lymphomas. The latter includes entities where the large B cells are primarily neoplastic (classical and nodular lymphocyte-predominant Hodgkin lymphomas and T cell/histiocyte-rich large B cell lymphoma) as well as T cell lymphomas such as angioimmunoblastic T cell lymphoma where the large B cells represent an epiphenomenon and may or may not be neoplastic. Read More

    Serum ferritin level is a prognostic marker in patients with peripheral T-cell lymphoma.
    Int J Lab Hematol 2017 Feb 24;39(1):112-117. Epub 2016 Nov 24.
    Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
    Introduction: The prognostic value of serum ferritin level in patients with peripheral T-cell lymphoma (PTCL) remains unknown.

    Methods: We retrospectively analyzed clinical data from 78 consecutive patients with newly diagnosed PTCL that were treated with anthracycline-containing regimens between 1998 and 2011.

    Results: The patients consisted of 50 males and 28 females with a median age of 64 years (range, 16-83 years). Read More

    Development of T follicular helper cells and their role in disease and immune system.
    Biomed Pharmacother 2016 Dec 15;84:1668-1678. Epub 2016 Nov 15.
    Microbial biotechnology, Islamic azad University Damghan branch, Iran.
    The T follicular helper cells (TFH) are a subset of CD4+ T cells specialized to regulate antibody responses. The production of these cells is associated with the dendritic cells (DCs) and B cells. TFH cells help B cells form germinal centers (GC) differentiate into memory and plasma cells (antibody-secreting cells) as humoral responses. Read More

    Discussion of 18F-FDG PET/CT imaging characteristics and diagnostic values of angioimmunoblastic T-cell lymphoma.
    Leuk Lymphoma 2016 Nov 10:1-8. Epub 2016 Nov 10.
    a Department of PET Center , Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China.
    The aim of this study was to discuss (18)F-FDG PET/CT imaging characteristics and diagnostic values of angioimmunoblastic T-cell lymphoma (AITL). The PET/CT features of 24 cases of pathologically confirmed AITL were analyzed. The individual and total diagnostic values of 13 sites using computed tomography (CT) and positron emission tomography (PET)/CT were calculated. Read More

    Cyclin D1 expression in peripheral T-cell lymphomas.
    Mod Pathol 2016 Nov 29;29(11):1306-1312. Epub 2016 Jul 29.
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
    Cyclin D1 is an important regulator of the cell cycle and overexpression of this protein by immunohistochemistry is characteristically seen in mantle cell lymphoma and other B-cell neoplasms. However, little is known about the expression of this protein in T-cell lymphomas. Cyclin-dependent kinase pathway inhibitors are in development, therefore identifying cyclin D1-positive T-cell lymphomas may provide a therapeutic target in a disease where novel treatments are urgently needed. Read More

    T-cell lymphomas, a challenging disease: types, treatments, and future.
    Int J Clin Oncol 2017 Feb 14;22(1):18-51. Epub 2016 Oct 14.
    Department of Internal Medicine, New York University, New York, NY, USA.
    T-cell lymphomas are rare and aggressive malignancies associated with poor outcome, often because of the development of resistance in the lymphoma against chemotherapy as well as intolerance in patients to the established and toxic chemotherapy regimens. In this review article, we discuss the epidemiology, pathophysiology, current standard of care, and future treatments of common types of T-cell lymphomas, including adult T-cell leukemia/lymphoma, angioimmunoblastic T-cell lymphoma, anaplastic large-cell lymphoma, aggressive NK/T-cell lymphoma, and cutaneous T-cell lymphoma. Read More

    Burrowing through the Heterogeneity: Review of Mouse Models of PTCL-NOS.
    Front Oncol 2016 26;6:206. Epub 2016 Sep 26.
    University of Nebraska at Omaha , Omaha, NE , USA.
    Currently, there are 19 different peripheral T-cell lymphoma (PTCL) entities recognized by the World Health Organization; however, ~70% of PTCL diagnoses fall within one of three subtypes [i.e., peripheral T-cell lymphoma not otherwise specified (PTCL-NOS), anaplastic large-cell lymphoma, and angioimmunoblastic T-cell lymphoma]. Read More

    Value of interim FDG PET/CT for predicting outcome of patients with angioimmunoblastic T-cell lymphoma.
    Leuk Lymphoma 2016 Oct 9:1-8. Epub 2016 Oct 9.
    a Departments of Nuclear Medicine and Division of Hematology-Oncology , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
    Subjects were 45 patients with angioimmunoblastic T-cell lymphoma (AITL) who underwent 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography/computed tomography (PET/CT) at baseline and interim after 2-4 cycles. Predictors of progression-free survival (PFS) and overall survival (OS) were assessed. Positive interim PET/CT (Deauville score ≥3) was a significant independent predictor of poor PFS (Hazard ratio, 4. Read More

    Mycosis Fungoides Associated with Kaposi's Sarcoma, T-cell Rich B-cell Lymphoma, and T-cell Lymphoma with Angioimmunoblastic Features.
    Acta Dermatovenerol Croat 2016 Aug;24(3):218-20
    Ilan Goldberg, MD, Department of Dermatology, Tel Aviv Sourasky Medical Center, 6, Weizmann Street, Tel Aviv 64239, Israel;
    A patient with mycosis fungoides (MF), Kaposi's sarcoma, T-cell rich B-cell lymphoma, and T-cell lymphoma with angioimmunoblastic features is described. The appearance of multiple malignancies in this patient may have been caused by previous exposure to radiation in the Chernobyl accident and/or systemic chemotherapy for the initial T-cell rich B-cell lymphoma which he underwent. Read More

    Long-Term Treatment with Romidepsin in Patients with Peripheral T-Cell Lymphoma.
    Case Rep Hematol 2016 25;2016:8175957. Epub 2016 Aug 25.
    Viollier Weintraub, Geneva, Switzerland.
    Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of aggressive non-Hodgkin lymphomas. Angioimmunoblastic T-cell lymphoma (AITL) is a common subtype of PTCL, and patients with AITL typically have a poor prognosis with limited treatment options. Clinical studies have demonstrated the activity of romidepsin, a structurally unique, potent, bicyclic class 1 selective histone deacetylase inhibitor, in patients with relapsed or refractory AITL. Read More

    Molecular mechanisms of angioimmunoblastic T-cell lymphoma development.
    Rinsho Ketsueki 2016 Aug;57(8):1038-43
    Department of Hematology, Faculty of Medicine, University of Tsukuba.
    The molecular pathogenesis of peripheral T-cell lymphoma (PTCL) has gradually been clarified in terms of genomic abnormalities. Insights into these genomic abnormalities have provided clues to understanding the pathogenesis of PTCL. Furthermore, the origins of lymphoma cells have been clarified by investigating the distribution of genomic abnormalities in tumor cells and non-tumor blood cells. Read More

    Angioimmunoblastic T-cell lymphoma with a clonal plasma cell proliferation that underwent immunoglobulin isotype switch in the skin, coinciding with cutaneous disease progression.
    J Cutan Pathol 2016 Dec 4;43(12):1203-1210. Epub 2016 Oct 4.
    Pathology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
    Plasma cell proliferations in specific cutaneous lesions of angioimmunoblastic T-cell lymphoma(AITL) are very uncommon. Here, we report a case of clonal plasma cell proliferation in skin with heavy-chain-immunoglobulin-isotype-switch after cutaneous disease progression. Histopathologically, initial plaque lesions were suggestive of marginal-zone B-cell-lymphoma. Read More

    Cerebellar EBV-associated diffuse large B cell lymphoma following angioimmunoblastic T cell lymphoma.
    J Hematop 2015 Dec 18;8(4):235-241. Epub 2015 Mar 18.
    Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
    Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic T cell lymphoma (AITL). Although both nodal and extranodal sites of involvement have been described, central nervous system involvement by B cell lymphoma following AITL has not previously been documented. We report a first example of such unusual presentation, in which an 80-year-old man developed diffuse large B cell lymphoma (DLBCL) in the cerebellum 4 months after the initial diagnosis of AITL. Read More

    Molecular evolution and the global reemergence of enterovirus D68 by genome-wide analysis.
    Medicine (Baltimore) 2016 Aug;95(31):e4416
    aDepartment of Laboratory Medicine, Linkou Chang Gung Memorial Hospital bDepartment of Medical Biotechnology and Laboratory Science cResearch Center for Emerging Viral Infections, Chang Gung University dDepartment of Pediatrics, Linkou Chang Gung Memorial Hospital eCollege of Medicine, Chang Gung University fDepartment of Respiratory Therapy gDepartment of Pulmonary and Critical Care Medicine, Linkou Chang Gung Memorial Hospital hDepartment of Respiratory Therapy iDepartment of Pulmonary and Critical Care Medicine, Chang Gung University, Taoyuan, Taiwan.
    Human enterovirus D68 (EV-D68) was first reported in the United States in 1962; thereafter, a few cases were reported from 1970 to 2005, but 2 outbreaks occurred in the Philippines (2008) and the United States (2014). However, little is known regarding the molecular evolution of this globally reemerging virus due to a lack of whole-genome sequences and analyses. Here, all publically available sequences including 147 full and 1248 partial genomes from GenBank were collected and compared at the clade and subclade level; 11 whole genomes isolated in Taiwan (TW) in 2014 were also added to the database. Read More

    First-line therapy of peripheral T-cell lymphoma: extension and long-term follow-up of a study investigating the role of autologous stem cell transplantation.
    Blood Cancer J 2016 Jul 29;6(7):e452. Epub 2016 Jul 29.
    Hematology and Medical Oncology Clinic, Paracelsus Medical University Nuernberg, Nürnberg, Germany.
    Current guidelines recommend consolidation with autologous stem cell transplantation (autoSCT) after induction chemotherapy for most patients with peripheral T-cell lymphoma (PTCL). This assumption is based on five prospective phase II studies, three of which included <50 patients with limited follow-up. Here we present the final analysis of the prospective German study. Read More

    Angioimmunoblastic T-Cell Lymphoma in a Patient with Klinefelter Syndrome.
    Am J Case Rep 2016 Jul 25;17:529-34. Epub 2016 Jul 25.
    Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
    BACKGROUND Although patients with Klinefelter syndrome have elevated risk and incidence rates for several solid cancers, reports on the incidence of hematological malignancies have been equivocal. CASE REPORT We report a patient diagnosed with angioimmunoblastic T-cell lymphoma in whom Klinefelter syndrome was newly detected. Moreover, we discuss the development of a variety of lymphomas in patients with Klinefelter syndrome. Read More

    A Clinicopathologic Study of Lennert Lymphoma and Possible Prognostic Factors: The Importance of Follicular Helper T-cell Markers and the Association With Angioimmunoblastic T-cell Lymphoma.
    Am J Surg Pathol 2016 Sep;40(9):1249-60
    *Department of Pathology, Kurume University School of Medicine, Kurume, Japan §Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan †Department of Medicine, Division of Hematology and Rheumatology ‡Department of Biomedical Sciences, Division of Biochemistry, Nihon University School of Medicine, Tokyo, Japan.
    Lennert lymphoma (LeL) is a variant of peripheral T-cell lymphoma, not otherwise specified. Few clinicopathologic studies have investigated LeL, which is a rare disease. Here, we analyzed the clinicopathologic features of 26 patients with LeL to identify potential prognostic factors. Read More


    Early diagnosis and successful treatment of disseminated toxoplasmosis after cord blood transplantation.
    Rinsho Ketsueki 2016 Jun;57(6):736-41
    Department of Hematology, Nagano Red Cross Hospital.
    A 66-year-old woman with refractory angioimmunoblastic T-cell lymphoma underwent cord blood transplantation. Prior to transplantation, a serological test for Toxoplasma gondii-specific IgG antibodies was positive. On day 96, she exhibited fever and dry cough. Read More

    Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas.
    Blood 2016 Sep 1;128(11):1490-502. Epub 2016 Jul 1.
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;
    Angioimmunoblastic T-cell lymphoma (AITL) and other lymphomas derived from follicular T-helper cells (TFH) represent a large proportion of peripheral T-cell lymphomas (PTCLs) with poorly understood pathogenesis and unfavorable treatment results. We investigated a series of 85 patients with AITL (n = 72) or other TFH-derived PTCL (n = 13) by targeted deep sequencing of a gene panel enriched in T-cell receptor (TCR) signaling elements. RHOA mutations were identified in 51 of 85 cases (60%) consisting of the highly recurrent dominant negative G17V variant in most cases and a novel K18N in 3 cases, the latter showing activating properties in in vitro assays. Read More

    Response to 5-azacytidine in a patient with TET2-mutated angioimmunoblastic T-cell lymphoma and chronic myelomonocytic leukaemia preceded by an EBV-positive large B-cell lymphoma.
    Hematol Oncol 2016 Jun 29. Epub 2016 Jun 29.
    Clinical Hematology, IMAGINE Institute, Paris Descartes-Sorbonne Paris Cité University, Necker Hospital, AP-HP, Paris, France.
    We report the case of a patient with a history of Epstein-Barr virus-positive large B-cell lymphoma, who relapsed with an angioimmunoblastic T-cell lymphoma (AITL) associated with a chronic myelomonocytic leukaemia (CMML). We performed targeted next-generation sequencing on CMML and AITL DNA, which revealed mutations of TET2, DNMT3A, SRSF2, NRAS and IDH1, thus confirming that the spectrum of AITL mutations share similarities with myeloid disorders. The frequencies of TET2/DNMT3A and SRSF2 variants could support the hypothesis that TET2/DNMT3A mutations occurred in an early progenitor cell, which later progressed to both the AITL and CMML clones. Read More

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