923 results match your criteria Angiogenesis[Journal]


B-cell non-Hodgkin lymphoma: importance of angiogenesis and antiangiogenic therapy.

Authors:
Lei Jiang Nailin Li

Angiogenesis 2020 May 25. Epub 2020 May 25.

Department of Medicine-Solna, Clinical Pharmacology Group, Karolinska Institutet, Karolinska University Hospital, 171 76, Stockholm, Sweden.

Angiogenesis is critical for the initiation and progression of solid tumors, as well as hematological malignancies. While angiogenesis in solid tumors has been well characterized, a large body of investigation is devoted to clarify the impact of angiogenesis on lymphoma development. B-cell non-Hodgkin lymphoma (B-NHL) is the most common lymphoid malignancy with a highly heterogeneity. Read More

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http://dx.doi.org/10.1007/s10456-020-09729-7DOI Listing

Hedgehog signaling promotes angiogenesis directly and indirectly in pancreatic cancer.

Angiogenesis 2020 May 22. Epub 2020 May 22.

Department of Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Their 623, Boston, MA, 02114, USA.

Introduction: The inhibition of Hedgehog (Hh) signaling in pancreatic ductal adenocarcinoma (PDAC) reduces desmoplasia and promotes increased vascularity. In contrast to these findings, the Hh ligand Sonic Hedgehog (SHH) is a potent proangiogenic factor in non-tumor models. The aim of this study was to determine the molecular mechanisms by which SHH affects the tumor stroma and angiogenesis. Read More

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http://dx.doi.org/10.1007/s10456-020-09725-xDOI Listing

Heterogeneity and chimerism of endothelial cells revealed by single-cell transcriptome in orthotopic liver tumors.

Angiogenesis 2020 May 21. Epub 2020 May 21.

Regeneron Pharmaceuticals, 777 Old Saw Mill River Rd, Tarrytown, NY, 10591, USA.

The liver is a common host organ for cancer, either through lesions that arise in liver epithelial cells [e.g., hepatocellular carcinoma (HCC)] or as a site of metastasis by tumors arising in other organs (e. Read More

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http://dx.doi.org/10.1007/s10456-020-09727-9DOI Listing

Tumor-derived exosomes promote angiogenesis via adenosine A receptor signaling.

Angiogenesis 2020 May 18. Epub 2020 May 18.

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.

Rationale: One hallmark of tumor-derived exosomes (TEX) is the promotion of cancer progression by stimulating angiogenesis. This study was performed to evaluate the role of adenosine receptors in TEX-induced angiogenesis.

Methods: TEX produced by UMSCC47 head and neck cancer cell line were isolated by mini size exclusion chromatography (mini-SEC). Read More

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http://dx.doi.org/10.1007/s10456-020-09728-8DOI Listing

Endothelial deletion of ADAM10, a key regulator of Notch signaling, causes impaired decidualization and reduced fertility in female mice.

Angiogenesis 2020 May 8. Epub 2020 May 8.

Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA.

During the initiation of pregnancy, the vasculature of the implantation site expands rapidly, yet little is known about this process or its role in fertility. Here, we report that endothelial-specific deletion of a disintegrin and metalloprotease 10 (ADAM10), an essential regulator of Notch signaling, results in severe subfertility in mice. We found that implantation sites develop until 5. Read More

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http://dx.doi.org/10.1007/s10456-020-09723-zDOI Listing

Simultaneous fluorescence imaging of distinct nerve and blood vessel patterns in dual Thy1-YFP and Flt1-DsRed transgenic mice.

Angiogenesis 2020 May 5. Epub 2020 May 5.

Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

Blood vessels and nerve tissues are critical to the development and functionality of many vital organs. However, little is currently known about their interdependency during development and after injury. In this study, dual fluorescence transgenic reporter mice were utilized to observe blood vessels and nervous tissues in organs postnatally. Read More

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http://dx.doi.org/10.1007/s10456-020-09724-yDOI Listing

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation.

Angiogenesis 2020 Apr 30. Epub 2020 Apr 30.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Capillary lymphatic venous malformations (CLVM) are complex vascular anomalies characterized by aberrant and enlarged lymphatic and blood vessels. CLVM appear during fetal development and enlarge after birth, causing life-long complications such as coagulopathy, pulmonary embolism, chronic pain, and disfigurement. Treatment includes surgical debulking, amputation, and recurrent sclerotherapy. Read More

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http://dx.doi.org/10.1007/s10456-020-09722-0DOI Listing

Apatinib as targeted therapy for advanced bone and soft tissue sarcoma: a dilemma of reversing multidrug resistance while suffering drug resistance itself.

Angiogenesis 2020 Apr 24. Epub 2020 Apr 24.

Department of Physiology, Army Medical University, Chongqing, 400038, China.

Bone and soft tissue sarcomas are rare malignant tumors originated from mesenchymal tissues. They harbor more than 50 distinct subtypes and differ in pathological features and clinical courses. Despite the significant improvements in modern multi-modality treatment, the outcomes and overall survival rates remain poor for patients with advanced, refractory, metastatic, or relapsed diseases. Read More

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http://dx.doi.org/10.1007/s10456-020-09716-yDOI Listing

Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis.

Angiogenesis 2020 Apr 19. Epub 2020 Apr 19.

Institute of Pharmaceutical Sciences, ETH Zurich, 8093, Zurich, Switzerland.

MAFB is a transcription factor involved in the terminal differentiation of several cell types, including macrophages and keratinocytes. MAFB is also expressed in lymphatic endothelial cells (LECs) and is upregulated by VEGF-C/VEGFR-3 signaling. Recent studies have revealed that MAFB regulates several genes involved in lymphatic differentiation and that global Mafb knockout mice show defects in patterning of lymphatic vessels during embryogenesis. Read More

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http://dx.doi.org/10.1007/s10456-020-09721-1DOI Listing

Raftlin is recruited by neuropilin-1 to the activated VEGFR2 complex to control proangiogenic signaling.

Angiogenesis 2020 Apr 9. Epub 2020 Apr 9.

School of Biochemistry, Biomedical Sciences Building, University of Bristol, University Walk, Bristol, BS8 1TD, UK.

Background: VEGFR2 (vascular endothelial growth factor receptor 2) is the major pro-angiogenic receptor in endothelial cells. Compared to other members of the receptor tyrosine kinase family, we know relatively few VEGFR2 signaling partners. Our objective was to use mass spectrometry-based proteomics to identify novel binding partners of activated VEGFR2. Read More

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http://dx.doi.org/10.1007/s10456-020-09715-zDOI Listing

New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury.

Angiogenesis 2020 Apr 3. Epub 2020 Apr 3.

Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.

As reperfusion therapies have become more widely used in acute myocardial infarction patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion-induced cardiac injury has become increasingly evident. The features of cardiac ischemia-reperfusion (I/R) injury include microvascular perfusion defects, platelet activation and sequential cardiomyocyte death due to additional ischemic events at the reperfusion stage. Microvascular obstruction, defined as a no-reflow phenomenon, determines the infarct zone, myocardial function and peri-operative mortality. Read More

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http://dx.doi.org/10.1007/s10456-020-09720-2DOI Listing
April 2020
4.876 Impact Factor

Angiostatic effects of ascorbic acid: current status and future perspectives.

Angiogenesis 2020 Apr 2. Epub 2020 Apr 2.

Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, 8100, Gopalganj, Bangladesh.

Anti-angiogenesis effect of ascorbic acid (AA) is still controversial. However, most of the scientific evidence suggests that AA has anti-angiogenesis effects on a number of test systems, including laboratory animals, human beings, and their derived cell lines. The information provided in this paper suggests that AA may be a hopeful angiostatic agent for the treatment of cancer. Read More

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http://dx.doi.org/10.1007/s10456-020-09719-9DOI Listing

Lymphangiogenesis and accumulation of reparative macrophages contribute to liver repair after hepatic ischemia-reperfusion injury.

Angiogenesis 2020 Mar 11. Epub 2020 Mar 11.

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan.

Hepatic tissue repair plays a critical role in determining the outcome of hepatic ischemia-reperfusion (I/R) injury. Hepatic lymphatics participate in the clearance of dead tissues and contribute to the reparative process after acute hepatic injury; however, it remains unknown whether lymphangiogenesis in response to hepatic inflammation is involved in liver repair. Herein, we determined if hepatic lymphangiogenesis improves liver repair after hepatic I/R injury. Read More

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http://dx.doi.org/10.1007/s10456-020-09718-wDOI Listing

Retraction Note to: Semaphorin 4D cooperates with VEGF to promote angiogenesis and tumor progression.

Angiogenesis 2020 05;23(2):267

Department of Oncology and Diagnostic Sciences, University of Maryland Dental School, 650 West Baltimore Street, 7-North, Baltimore, MD, 21201, USA.

The Editors-in-Chief have retracted this article [1] following an investigation by the University of Maryland. The institution found that in Figures 1B and 1D, the cell lines are different and all published histograms show SEMA4D mRNA level whereas Excel data have two histograms showing SEMA4D expression and two histograms showing VEGF expression. In Figure 2B, the metadata for one image shows different treatment conditions than those reported in the article. Read More

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http://dx.doi.org/10.1007/s10456-020-09709-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175597PMC

D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3.

Angiogenesis 2020 Mar 9. Epub 2020 Mar 9.

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

N-formyl peptide receptors (FPRs) are G protein-coupled receptors involved in the recruitment and activation of immune cells in response to pathogen-associated molecular patterns. Three FPRs have been identified in humans (FPR1-FPR3), characterized by different ligand properties, biological function and cellular distribution. Recent findings from our laboratory have shown that the peptide BOC-FLFLF (L-BOC2), related to the FPR antagonist BOC2, acts as an angiogenesis inhibitor by binding to various angiogenic growth factors, including vascular endothelial growth factor-A (VEGF). Read More

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http://dx.doi.org/10.1007/s10456-020-09714-0DOI Listing

Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice.

Angiogenesis 2020 Mar 5. Epub 2020 Mar 5.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.

To examine whether free fatty acid receptor 4 (FFAR4) activation can protect against choroidal neovascularization (CNV), which is a common cause of blindness, and to elucidate the mechanism underlying the inhibition, we used the mouse model of laser-induced CNV to mimic angiogenic aspects of age-related macular degeneration (AMD). Laser-induced CNV was compared between groups treated with an FFAR4 agonist or vehicle, and between FFAR4 wild-type (Ffar4) and knock out (Ffar4) mice on a C57BL/6J/6N background. The ex vivo choroid-sprouting assay, including primary retinal pigment epithelium (RPE) and choroid, without retina was used to investigate whether FFAR4 affects choroidal angiogenesis. Read More

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http://dx.doi.org/10.1007/s10456-020-09717-xDOI Listing

Intranasal Efudix reduces epistaxis in hereditary hemorrhagic telangiectasia.

Angiogenesis 2020 Feb 28. Epub 2020 Feb 28.

Department of Otorhinolaryngology, Sint Antonius Hospital, Nieuwegein, The Netherlands.

Background: Local application of fluorouracil (Efudix, 5-FU) induces sclerosis in patients with sinonasal tumors and superficial basocellular skin carcinoma. As a 'back against the wall' treatment, we investigated the local effect of nasally applied 5-FU and whether this could decrease the burden of severe epistaxis in patients with hereditary hemorrhagic telangiectasia (HHT).

Methods: HHT patients with severe and frequent epistaxis, subsequent anemia and a necessity for blood and/or iron infusions were treated with a nasal tampon with 5-FU. Read More

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http://dx.doi.org/10.1007/s10456-020-09712-2DOI Listing
February 2020

TMEM100 is a key factor for specification of lymphatic endothelial progenitors.

Angiogenesis 2020 Feb 28. Epub 2020 Feb 28.

Department of Physiology and Functional Genomics, College of Medicine, University of Florida, 1600 SW Archer Road, Room CG-20B, Gainesville, FL, USA.

Background: TMEM100 is identified as a downstream gene of bone morphogenetic protein 9 (BMP9) signaling via activin receptor-like kinase 1 (ALK1), which is known to participate in lymphangiogenesis as well as angiogenesis. TMEM100 has been shown to be important for blood vessel formation and maintenance, but its role in the development of lymphatic vasculature remains unknown. The objective is to investigate the role of TMEM100 in development of the lymphatic system. Read More

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http://dx.doi.org/10.1007/s10456-020-09713-1DOI Listing
February 2020
4.876 Impact Factor

Retraction Note to: The Semaphorin 4D-Plexin-B1-RhoA signaling axis recruits pericytes and regulates vascular permeability through endothelial production of PDGF-B and ANGPTL4.

Angiogenesis 2020 05;23(2):269

Department of Oncology and Diagnostic Sciences, University of Maryland Dental School, 650 West Baltimore Street, 7-North, Baltimore, MD, 21201, USA.

The Editors-in-Chief have retracted this article [1] following an investigation by the University of Maryland. The institution found that in Figure 1C, the graph showing PDGF-B does not match the original data for the 24-hour time point. The graph shows the value to be over 1000 pg/ml, but the original data have a value of 106. Read More

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http://dx.doi.org/10.1007/s10456-020-09710-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171600PMC

Correction to: Rho-mediated activation of PI(4)P5K and lipid second messengers is necessary for promotion of angiogenesis by Semaphorin 4D.

Angiogenesis 2020 May;23(2):265-266

Department of Oncology and Diagnostic Sciences, University of Maryland Dental School, 650 West Baltimore Street, 7-North, Baltimore, MD, 21201, USA.

Figure 3c of this article originally contained standard deviation values which had not been calculated correctly. A single standard deviation value was used for all 5 time points for each condition. Read More

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http://dx.doi.org/10.1007/s10456-020-09711-3DOI Listing

Decylubiquinone suppresses breast cancer growth and metastasis by inhibiting angiogenesis via the ROS/p53/ BAI1 signaling pathway.

Angiogenesis 2020 Feb 4. Epub 2020 Feb 4.

Institute of Basic Medical Sciences, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China.

Breast cancer is one of the most common cancers worldwide with a rising incidence, and is the leading cause of cancer-related death among females. Angiogenesis plays an important role in breast cancer growth and metastasis. In this study, we identify decylubiquinone (DUb), a coenzyme Q analog, as a promising anti-breast cancer agent through suppressing tumor-induced angiogenesis. Read More

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http://dx.doi.org/10.1007/s10456-020-09707-zDOI Listing
February 2020
4.876 Impact Factor

Matrix deformations around angiogenic sprouts correlate to sprout dynamics and suggest pulling activity.

Angiogenesis 2020 Jan 29. Epub 2020 Jan 29.

Biomechanics Section (BMe), Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.

Angiogenesis is the formation of new blood vessels from the pre-existing vasculature. It is essential for normal tissue growth and regeneration, and also plays a key role in many diseases [Carmeliet in Nat Med 9:653-660, 2003]. Cytoskeletal components have been shown to be important for angiogenic sprout initiation and maintenance [Kniazeva and Putnam in Am J Physiol 297:C179-C187, 2009] as well as endothelial cell shape control during invasion [Elliott et al. Read More

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http://dx.doi.org/10.1007/s10456-020-09708-yDOI Listing
January 2020

Positive and negative feedback mechanisms controlling tip/stalk cell identity during sprouting angiogenesis.

Authors:
Coert Margadant

Angiogenesis 2020 05;23(2):75-77

Sanquin Research and Landsteiner Laboratory, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands.

Vascular endothelial growth factor-A (VEGF-A/VEGF) interaction with VEGF receptor 2 (VEGFR2) is key for sprouting angiogenesis in health and disease. VEGF/VEGFR2 signaling promotes endothelial proliferation and migration, as well as the hierarchical organization into leader (tip) and follower (stalk) cells via a dynamic interplay with Notch. Recent studies reveal novel molecular mechanisms to fine-tune VEGF/Notch signaling and tip/stalk cell function during sprouting angiogenesis. Read More

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http://dx.doi.org/10.1007/s10456-020-09706-0DOI Listing

Age-related structural alterations of skeletal muscles and associated capillaries.

Angiogenesis 2020 05 28;23(2):79-82. Epub 2020 Jan 28.

Shiseido Global Innovation Center, 1-2-11Nishi-ku Yokohama, Takashima, 220-1100, Japan.

Aging is associated with a progressive decline in muscle mass, strength, and quality. We have previously demonstrated the important role of the blood vasculature system in ultraviolet (UV) light-induced changes in skin and its molecular mechanisms. Whereas recent findings revealed structural alterations of the cutaneous vasculature in aged and photoaged human skin, structural changes of blood vessels in skeletal muscles with age have remained unclear. Read More

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http://dx.doi.org/10.1007/s10456-020-09705-1DOI Listing

Targeting endothelial thioredoxin-interacting protein (TXNIP) protects from metabolic disorder-related impairment of vascular function and post-ischemic revascularisation.

Angiogenesis 2020 05 3;23(2):249-264. Epub 2020 Jan 3.

INSERM 1140, Innovative Therapies in Haemostasis, Faculty of Pharmacy, Université de Paris, 75006, Paris, France.

Introduction: Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biological functions, the contribution of endothelial TXNIP has not been well-defined in regards to endothelial and vascular function or in post-ischemic revascularisation. We postulated that inhibition of endothelial TXNIP with siRNA or in a Cre-LoxP system could be involved in protection from high fat, high protein, low carbohydrate (HFHPLC) diet-induced oxidative stress and endothelial dysfunction, leading to vascular damage and impaired revascularisation in vivo.

Methods And Results: To investigate the role of endothelial TXNIP, the TXNIP gene was deleted in endothelial cells using anti-TXNIP siRNA treatment or the Cre-LoxP system. Read More

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http://dx.doi.org/10.1007/s10456-019-09704-xDOI Listing

Continuous endoglin (CD105) overexpression disrupts angiogenesis and facilitates tumor cell metastasis.

Angiogenesis 2020 05 3;23(2):231-247. Epub 2020 Jan 3.

Renal and Cardiovascular Research Unit, Department of Physiology and Pharmacology, University of Salamanca, and the Biomedical Research Institute of Salamanca (IBSAL), Edificio Departamental, Campus Miguel de Unamuno, 37007, Salamanca, Spain.

Endoglin (CD105) is an auxiliary receptor for members of the TFG-β superfamily. Whereas it has been demonstrated that the deficiency of endoglin leads to minor and defective angiogenesis, little is known about the effect of its increased expression, characteristic of several types of cancer. Angiogenesis is essential for tumor growth, so high levels of proangiogenic molecules, such as endoglin, are supposed to be related to greater tumor growth leading to a poor cancer prognosis. Read More

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http://dx.doi.org/10.1007/s10456-019-09703-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160077PMC

Impaired vascular endothelial growth factor expression and secretion during in vitro differentiation of human primary term cytotrophoblasts.

Angiogenesis 2020 05 1;23(2):221-230. Epub 2020 Jan 1.

Department of Obstetrics, Institut de Recherche Clinique Et Experimentale (IREC), Université Catholique de Louvain, Avenue Mounier 52, 5th floor, Woluwe-Saint-Lambert, 1200, Bruxelles, Belgium.

Vascular endothelial growth factor A (VEGF-A) is one of the main growth factors involved in placental vasculogenesis and angiogenesis, but its placental expression is still ambiguous. During in vitro cultures of primary term cytotrophoblasts, VEGF could not be detected in the supernatants by enzyme-linked immunosorbent assays (ELISA). One hypothesis is that VEGF is immediately and completely bound to its soluble receptor after secretion, and cannot be recognized by the antibodies used in the commercial ELISA kits. Read More

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http://dx.doi.org/10.1007/s10456-019-09702-zDOI Listing

Vessel co-option and resistance to anti-angiogenic therapy.

Angiogenesis 2020 02 21;23(1):55-74. Epub 2019 Dec 21.

Oncology R&D, AstraZeneca, Cambridge, UK.

Vessel co-option is a non-angiogenic mechanism of tumour vascularisation in which cancer cells utilise pre-existing blood vessels instead of inducing new blood vessel formation. Vessel co-option has been observed across a range of different tumour types, in both primary cancers and metastatic disease. Importantly, vessel co-option is now implicated as a major mechanism that mediates resistance to conventional anti-angiogenic drugs and this may help to explain the limited efficacy of this therapeutic approach in certain clinical settings. Read More

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http://dx.doi.org/10.1007/s10456-019-09698-6DOI Listing
February 2020

Role of VEGFs in metabolic disorders.

Angiogenesis 2020 05 18;23(2):119-130. Epub 2019 Dec 18.

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Obesity and metabolic disorders are important public health problems. In this review, the role of vasculature network and VEGF in the adipose tissue maintenance and supplementation is discussed. Angiogenesis is a key process implicated in regulation of tissues homeostasis. Read More

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http://dx.doi.org/10.1007/s10456-019-09700-1DOI Listing

BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance.

Angiogenesis 2020 05 11;23(2):203-220. Epub 2019 Dec 11.

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal-dominant vascular disorder characterized by development of high-flow arteriovenous malformations (AVMs) that can lead to stroke or high-output heart failure. HHT2 is caused by heterozygous mutations in ACVRL1, which encodes an endothelial cell bone morphogenetic protein (BMP) receptor, ALK1. BMP9 and BMP10 are established ALK1 ligands. Read More

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http://dx.doi.org/10.1007/s10456-019-09701-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165044PMC

Introduction to special issue: vascular co-option in cancer.

Authors:
Andrew C Dudley

Angiogenesis 2020 02;23(1):1-2

Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA, 22908, USA.

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http://dx.doi.org/10.1007/s10456-019-09699-5DOI Listing
February 2020
5 Reads

Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET).

Angiogenesis 2020 05 26;23(2):193-202. Epub 2019 Nov 26.

Department of Medical Oncology, Institut Curie, PSL Research University, 26 rue d'Ulm, 75005, Paris & Saint Cloud, France.

Background: Proof of concept studies has reported that circulating endothelial cell (CEC) count may be associated with the outcome of HER2-negative metastatic breast cancer (mBC) patients treated by chemotherapy and the anti-VEGF antibody bevacizumab. We report the results obtained in an independent prospective validation cohort (COMET study, NCT01745757).

Methods: The main baseline criteria were HER2-negative mBC, performance status 0-2 and no prior chemotherapy for metastatic disease. Read More

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http://dx.doi.org/10.1007/s10456-019-09697-7DOI Listing

The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells.

Angiogenesis 2020 05 21;23(2):179-192. Epub 2019 Nov 21.

Department of Pre-Therapeutic Target Discovery, Regeneron Pharmaceuticals Inc, Tarrytown, NY, 10591, USA.

Angiogenesis is largely driven by motile endothelial tip-cells capable of invading avascular tissue domains and enabling new vessel formation. Highly responsive to Vascular Endothelial Growth-Factor-A (VEGFA), endothelial tip-cells also suppress angiogenic sprouting in adjacent stalk cells, and thus have been a primary therapeutic focus in addressing neovascular pathologies. Surprisingly, however, there remains a paucity of specific endothelial tip-cell markers. Read More

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http://dx.doi.org/10.1007/s10456-019-09696-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160073PMC

Angiotropism, pericytic mimicry and extravascular migratory metastasis: an embryogenesis-derived program of tumor spread.

Angiogenesis 2020 02 12;23(1):27-41. Epub 2019 Nov 12.

Department of Translational Research, Institut Curie, Paris, France.

Intravascular dissemination of tumor cells is the accepted mechanism of cancer metastasis. However, the phenomenon of angiotropism, pericyte mimicry (PM), and extravascular migratory metastasis (EVMM) has questioned the concept that tumor cells metastasize exclusively via circulation within vascular channels. This new paradigm of cancer spread and metastasis suggests that metastatic cells employ embryonic mechanisms for attachment to the abluminal surfaces of blood vessels (angiotropism) and spread via continuous migration, competing with and replacing pericytes, i. Read More

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http://dx.doi.org/10.1007/s10456-019-09695-9DOI Listing
February 2020

Reconciling the distinct roles of angiogenic/anti-angiogenic factors in the placenta and maternal circulation of normal and pathological pregnancies.

Angiogenesis 2020 05 9;23(2):105-117. Epub 2019 Nov 9.

Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

A branched vascular network is crucial to placental development and is dependent on factors such as vascular endothelial growth factor (VEGF), placental growth factor (PlGF), angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng) to regulate blood vessel growth. Imbalances in these factors can lead to aberrant placental vascular development. Throughout pregnancy, these factors are also released into the maternal circulation to aid in adapting the maternal cardiovascular system to pregnancy. Read More

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http://dx.doi.org/10.1007/s10456-019-09694-wDOI Listing
May 2020
1 Read

Vascular co-option in brain metastasis.

Angiogenesis 2020 02 7;23(1):3-8. Epub 2019 Nov 7.

Brain Metastasis Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.

Vascular co-option by brain metastasis-initiating cells has been demonstrated as a critical step in organ colonization. The physical interaction between the cancer cell and the endothelial cell is mediated by integrins and L1CAM and could be involved in aggressive growth but also latency and immune evasion. The key involvement of vascular co-option in brain metastasis has created an emerging field that aims to identify critical targets as well as effective inhibitors with the goal of preventing brain metastases. Read More

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http://dx.doi.org/10.1007/s10456-019-09693-xDOI Listing
February 2020

Vessel co-option in glioblastoma: emerging insights and opportunities.

Angiogenesis 2020 02 2;23(1):9-16. Epub 2019 Nov 2.

Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

Vessel co-option is the movement of cancer cells towards and along the pre-existing vasculature and is an alternative to angiogenesis to gain access to nutrients. Vessel co-option has been shown as a strategy employed by some glioblastoma (GBM) cells to invade further into the brain, leading to one of the greatest challenges in treating GBM. In GBM, vessel co-option may be an intrinsic feature or an acquired mechanism of resistance to anti-angiogenic treatment. Read More

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http://dx.doi.org/10.1007/s10456-019-09691-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012982PMC
February 2020
4.876 Impact Factor

Oxygen sensing decoded: a Nobel concept in biology.

Angiogenesis 2019 11;22(4):471-472

Karp Family Research Labs, Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.

Oxygen is essential to most organisms as it is a necessity for aerobic metabolism and energy production. Too much or too little oxygen can be deadly, such that mechanisms for fast and titrated response to changing oxygen levels are crucial. These mechanisms have evolved from the studies of Gregg L. Read More

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http://dx.doi.org/10.1007/s10456-019-09692-yDOI Listing
November 2019

Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer.

Angiogenesis 2020 05 30;23(2):159-177. Epub 2019 Oct 30.

Institute of Medical Genetics, Medical University of Vienna, Währinger Straße 10, 1090, Vienna, Austria.

WNT2 acts as a pro-angiogenic factor in placental vascularization and increases angiogenesis in liver sinusoidal endothelial cells (ECs) and other ECs. Increased WNT2 expression is detectable in many carcinomas and participates in tumor progression. In human colorectal cancer (CRC), WNT2 is selectively elevated in cancer-associated fibroblasts (CAFs), leading to increased invasion and metastasis. Read More

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http://dx.doi.org/10.1007/s10456-019-09688-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160098PMC
May 2020
4.876 Impact Factor

Pathological features of vessel co-option versus sprouting angiogenesis.

Angiogenesis 2020 02 26;23(1):43-54. Epub 2019 Oct 26.

Translational Cancer Research Unit, GZA Hospitals, Sint-Augustinus, Antwerp, Belgium.

Cancer cells can use existing blood vessels to acquire a vasculature. This process is termed 'vessel co-option'. Vessel co-option is an alternative to the growth of new blood vessels, or angiogenesis, and is adopted by a wide range of human tumour types growing within numerous tissues. Read More

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http://dx.doi.org/10.1007/s10456-019-09690-0DOI Listing
February 2020
3 Reads

Role of melatonin in controlling angiogenesis under physiological and pathological conditions.

Angiogenesis 2020 05 24;23(2):91-104. Epub 2019 Oct 24.

Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.

Angiogenesis depends on proangiogenic and anti-angiogenic molecules that regulate endothelial cell proliferation and migration. Well-regulated angiogenesis plays a pivotal role in many physiological conditions such as reproduction and embryonic development, while abnormal angiogenesis is also the basis of a variety of pathological processes including tumor metastasis and atherosclerotic plaque formation. Melatonin has a variety of biological effects, including inhibition of tumor metastasis, stabilizing atherosclerotic plaques, and the regulation of seasonal reproductive rhythms, etc. Read More

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http://dx.doi.org/10.1007/s10456-019-09689-7DOI Listing
May 2020
1 Read

Models and molecular mechanisms of blood vessel co-option by cancer cells.

Angiogenesis 2020 02 18;23(1):17-25. Epub 2019 Oct 18.

Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA, 22908, USA.

Cancer cells have diverse mechanisms for utilizing the vasculature; they can initiate the formation of new blood vessels from preexisting ones (sprouting angiogenesis) or they can form cohesive interactions with the abluminal surface of preexisting vasculature in the absence of sprouting (co-option). The later process has received renewed attention due to the suggested role of blood vessel co-option in resistance to antiangiogenic therapies and the reported perivascular positioning and migratory patterns of cancer cells during tumor dormancy and invasion, respectively. However, only a few molecular mechanisms have been identified that contribute to the process of co-option and there has not been a formal survey of cell lines and laboratory models that can be used to study co-option in different organ microenvironments; thus, we have carried out a comprehensive literature review on this topic and have identified cell lines and described the laboratory models that are used to study blood vessel co-option in cancer. Read More

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http://dx.doi.org/10.1007/s10456-019-09684-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018564PMC
February 2020

The tumor vasculature an attractive CAR T cell target in solid tumors.

Angiogenesis 2019 11;22(4):473-475

Angiogenesis Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

T cells armed with a chimeric antigen receptor, CAR T cells, have shown extraordinary activity against certain B lymphocyte malignancies, when targeted towards the CD19 B cell surface marker. These results have led to the regulatory approval of two CAR T cell approaches. Translation of this result to the solid tumor setting has been problematic until now. Read More

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http://dx.doi.org/10.1007/s10456-019-09687-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864117PMC
November 2019
1 Read

Highlights of the 13th International Hereditary Hemorrhagic Telangiectasia Scientific conference.

Angiogenesis 2019 11;22(4):583-584

The Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis Children's Hospital, St. Louis, MO, USA.

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http://dx.doi.org/10.1007/s10456-019-09685-xDOI Listing
November 2019

The protein tyrosine phosphatase PTPRJ/DEP-1 contributes to the regulation of the Notch-signaling pathway and sprouting angiogenesis.

Angiogenesis 2020 May 9;23(2):145-157. Epub 2019 Oct 9.

CRCHUM - Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.

The Dll4-Notch-signaling pathway regulates capillary sprouting via the specification of endothelial tip cells. While VEGF is a potent inducer of Dll4 expression, the intracellular mediators that stimulate its expression remain poorly defined. The protein tyrosine phosphatase PTPRJ/DEP-1 is required for angiogenesis in normal or pathological contexts through its modulation of VEGF signaling. Read More

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http://dx.doi.org/10.1007/s10456-019-09683-zDOI Listing
May 2020
4.876 Impact Factor

Stabilization of myeloid-derived HIFs promotes vascular regeneration in retinal ischemia.

Angiogenesis 2020 05 3;23(2):83-90. Epub 2019 Oct 3.

Division of Genetics, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.

The retinal vasculature is tightly organized in a structure that provides for the high metabolic demand of neurons while minimizing interference with incident light. The adverse impact of retinal vascular insufficiency is mitigated by adaptive vascular regeneration but exacerbated by pathological neovascularization. Aberrant growth of neovessels in the retina is responsible for impairment of sight in common blinding disorders including retinopathy of prematurity, proliferative diabetic retinopathy, and age-related macular degeneration. Read More

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http://dx.doi.org/10.1007/s10456-019-09681-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160070PMC
May 2020
2 Reads

Glucose withdrawal induces Endothelin 1 release with significant angiogenic effect from first trimester (FTM), but not term human umbilical cord perivascular cells (HUCPVC).

Angiogenesis 2020 05 1;23(2):131-144. Epub 2019 Oct 1.

Research Department, Create Program Inc., Suite 412, Toronto, ON, M5G 1N8, Canada.

Background: Perivascular cells (PVC) and their "progeny," mesenchymal stromal cells (MSC), have high therapeutic potential for ischemic diseases. While hypoxia can increase their angiogenic properties, the other aspect of ischemic conditions-glucose shortage-is deleterious for MSC and limits their therapeutic applicability. Regenerative cells in developing vascular tissues, however, can adapt to varying glucose environment and react in a tissue-protective manner. Read More

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http://link.springer.com/10.1007/s10456-019-09682-0
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http://dx.doi.org/10.1007/s10456-019-09682-0DOI Listing
May 2020
3 Reads

Intramuscular fast-flow vascular anomaly contains somatic MAP2K1 and KRAS mutations.

Angiogenesis 2019 11 5;22(4):547-552. Epub 2019 Sep 5.

Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.

Background: The term "intramuscular hemangioma capillary type" (IHCT) refers to a fast-flow vascular lesion that is classified as a tumor, although its phenotype overlaps with arteriovenous malformation (AVM). The purpose of this study was to identify somatic mutations in IHCT.

Methods: Affected tissue specimens were obtained during a clinically indicated procedure. Read More

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http://dx.doi.org/10.1007/s10456-019-09678-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868332PMC
November 2019
3 Reads

Revascularization after angiogenesis inhibition favors new sprouting over abandoned vessel reuse.

Angiogenesis 2019 11 4;22(4):553-567. Epub 2019 Sep 4.

Department of Ophthalmology, Institute for Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, 58183, Linköping, Sweden.

Inhibiting pathologic angiogenesis can halt disease progression, but such inhibition may offer only a temporary benefit, followed by tissue revascularization after treatment stoppage. This revascularization, however, occurs by largely unknown phenotypic changes in pathologic vessels. To investigate the dynamics of vessel reconfiguration during revascularization, we developed a model of reversible murine corneal angiogenesis permitting longitudinal examination of the same vasculature. Read More

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http://dx.doi.org/10.1007/s10456-019-09679-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863948PMC
November 2019
4.876 Impact Factor