103,606 results match your criteria Angiogenesis [Journal]


Mesenchymal stromal cells isolated from human fetal liver release soluble factors with a potential role in liver tissue repair.

Differentiation 2018 Dec 5;105:14-26. Epub 2018 Dec 5.

Department of Research, IRCCS-ISMETT, Palermo, Italy.

We isolated a population of proliferating cells from cultured human fetal hepatocytes of 16-22 weeks gestational age. The cells shared a similar phenotype to that of mesenchymal stromal cells (MSCs) according to the International Society for Cellular Therapy (ISCT), including plastic adherence, antigen expression profile, and in vitro multilineage differentiation potential. Fetal liver (FL)-MSCs expressed the albumin gene, and harbored a subpopulation of CK18 cells (20-40%), which defined their hepatic origin. Read More

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December 2018

Rapamycin administration during normal and diabetic pregnancy effects the mTOR and angiogenesis signaling in the rat placenta.

J Gynecol Obstet Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Department of Histology and Embryology, Medical Faculty, Akdeniz University, 07070, Antalya, Turkey. Electronic address:

Objective: The mammalian target of rapamycin (mTOR) signaling pathway has newly been recommended to be a nutrient sensor in the placenta. It is speculated that mTORC1 may be activated in diabetes, associated with increased placental nutrient availability. Thus, we aimed to investigate the mTOR signaling pathway both in diabetic and non-diabetic placenta and searched for the alterations of angiogenic factors VEGF, VEGFR1 and VEGFR2. Read More

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December 2018

Sustained release of recombinant thrombomodulin from cross-linked gelatin/hyaluronic acid hydrogels potentiate wound healing in diabetic mice.

Eur J Pharm Biopharm 2018 Dec 12. Epub 2018 Dec 12.

nstitute of Clinical Pharmacy and Pharmaceutical Sciences, Southern Taiwan University of Science and Technology, Tainan, Taiwan. Electronic address:

Thrombomodulin (TM) is a type-I transmembrane glycoprotein expressed on the surfaces of endothelial cells and epidermal keratinocytes. It is known to regulate blood coagulation, inflammation, and cell-cell adhesion. A recombinant TM, which contains an epidermal growth factor - like domain and serine/threonine-riches domain, has been demonstrated to stimulate cell proliferation and migration of keratinocytes and wound healing. Read More

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December 2018

Treadmill exercise ameliorates focal cerebral ischemia/reperfusion-induced neurological deficit by promoting dendritic modification and synaptic plasticity via upregulating caveolin-1/VEGF signaling pathways.

Exp Neurol 2018 Dec 12. Epub 2018 Dec 12.

Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou 325027, Zhejiang, China. Electronic address:

Dendritic and synaptic plasticity in the penumbra are important processes and are considered to be therapeutic targets of ischemic stroke. Treadmill exercise is known to be a beneficial treatment following stroke. However, its effects and potential mechanism in promoting dendritic and synaptic plasticity remain unknown. Read More

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December 2018

CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11.

J Cell Physiol 2018 Dec 14. Epub 2018 Dec 14.

Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.

Cancer stem cells (CSCs) exist in colon cancer and exhibit characteristics of stem cells which are due to lineages of tissues where they arise. Epithelial to mesenchymal transition (EMT)-undergoing cancer cells display CSC properties and therapeutic resistance. Cancer and stromal cells comprise of a tumor microenvironment. Read More

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December 2018

Identification of the salusin-β receptor using proteoliposomes embedded with endogenous membrane proteins.

Sci Rep 2018 Dec 14;8(1):17865. Epub 2018 Dec 14.

Protosera Inc., 4-3-22 Nishinakajima, Yodogawa-ku, Osaka, 532-0011, Japan.

Although orphan G protein-coupled receptors (GPCRs) have been used as targets to discover unidentified natural ligands, increasing numbers of non-GPCRs have been found to mediate important biological functions. Bioinformatics of genome and cDNA resources predict putative bioactive peptides, demanding an alternative approach to efficiently unravel cell surface targets. In silico analysis of a full-length cDNA library previously allowed us to identify salusin-β, a parasympathomimetic/pro-atherosclerotic peptide with unique physicochemical properties. Read More

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December 2018

Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Research Programs Unit, Genome-Scale Biology, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland.

Diabetic retinopathy (DR) is the most common diabetic microvascular complication and major cause of blindness in working-age adults. According to the level of microvascular degeneration and ischemic damage, DR is classified into non-proliferative DR (NPDR), and end-stage, proliferative DR (PDR). Despite advances in the disease etiology and pathogenesis, molecular understanding of end-stage PDR, characterized by ischemia- and inflammation-associated neovascularization and fibrosis, remains incomplete due to the limited availability of ideal clinical samples and experimental research models. Read More

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December 2018
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Hydroxysafflor yellow A suppresses angiogenesis of hepatocellular carcinoma through inhibition of p38 MAPK phosphorylation.

Biomed Pharmacother 2019 Jan 5;109:806-814. Epub 2018 Nov 5.

School of Basic Medical Sciences, Binzhou Medical University, Yantai 264003, China. Electronic address:

The antitumor effect of hydroxysafflor yellow A (HSYA), an active ingredient of the herb Carthamus tinctorius L. (Asteraceae) (safflower), was investigated in the current work. Researches of HSYA on vasculogenesis inhibition, along with the related molecular mechanisms, including the expression of MMP-2, MMP-9, and p38MAPK (COX-2, ATF-2, p-p38MAPK, and p38MAPK) signaling pathway in H22 tumor-bearing mice or HepG2 cells were performed. Read More

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January 2019

Wild edible onions - Allium flavum and Allium carinatum - successfully prevent adverse effects of chemotherapeutic drug doxorubicin.

Biomed Pharmacother 2019 Jan 1;109:2482-2491. Epub 2018 Dec 1.

University of Belgrade, Faculty of Biology, Studentski trg 16, 11000 Belgrade, Serbia.

The objective of this study was to evaluate potential of two chemically characterized edible wild onion species, Allium flavum and Allium carinatum, to reduce side effects of cytostatic doxorubicin (Dox). Since Dox application is mainly limited due to its high cardiotoxicity, while there are no approved cardioprotective agents for the prevention of Dox adverse effects, new co-treatments are urgently needed. Here, we showed that methanol extracts expressed high antioxidant activity and synergistically increased Dox anticancer activity against human hepatoma (HepG2) and lung carcinoma (A549) cells, while protected normal human fibroblasts (MRC-5) from Dox cytotoxicity. Read More

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January 2019

Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases.

Biomed Pharmacother 2019 Jan 28;109:2237-2251. Epub 2018 Nov 28.

Department of Biochemistry, BMS block-II, Sector 25, Panjab University, Chandigarh, India. Electronic address:

Resveratrol, a phytoalexin with a wide range of pharmacological properties is synthesised by plants in response to stress, injury, infection or UV radiations. As it is a secondary metabolite with many health promoting properties, various methods employing microorganisms and genetic manipulation of different synthetic enzymes, have been comprehensively studied to increase its production. Its rapid metabolism and low bioavailability have been addressed by the use of bio enhancers and nano-formulations. Read More

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January 2019
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In vivo pathogenesis of colon carcinoma and its suppression by hydrophilic fractions of Clematis flammula via activation of TRAIL death machinery (DRs) expression.

Biomed Pharmacother 2019 Jan 27;109:2182-2191. Epub 2018 Nov 27.

Laboratory of Biochemistry and Molecular Biology, Faculty of Sciences of Bizerte, University of Carthage, Tunisia.

This work focused on characterizing hydrophilic fractions of Clematis flammula (CFl). The data here clearly demonstrated that hydrolate fractions act as a free radical scavengers and inhibited proliferation of different cell lines in a time- and concentration-dependent manner, transwell, and with a significant cytotoxic effect. Treating cells with CFl had the effect of suppressing cell growth attenuated by ROS generation in colonic carcinoma. Read More

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January 2019

Chemopreventive mechanisms of galangin against hepatocellular carcinoma: A review.

Biomed Pharmacother 2019 Jan 26;109:2054-2061. Epub 2018 Nov 26.

Department of Ultrasound, Fuling Central Hospital of Chongqing City, Chongqing, China. Electronic address:

Hepatocellular carcinoma (HCC) is one of the most common cancers and has a high mortality rate in less developed countries, especially in China. Galangin (GA), one of the most important and naturally active flavonoids, extracted primarily from the root of Alpinia officinarum Hance, has been demonstrated to be effective in the treatment of HCC. It is a substance with defensive actions and a broad range of biological properties, including inhibitory effects on bacteria, fungi, viruses, the control of hypertension and diabetes, and chemoprevention of several cancers. Read More

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January 2019

Effectiveness of topical administration of Anethum graveolens essential oil on MRSA-infected wounds.

Biomed Pharmacother 2019 Jan 17;109:1650-1658. Epub 2018 Nov 17.

Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C. Evin, Tehran, Iran.

Medicinal plants are conventionally used for wound healing, but their action mechanisms are still unknown. The present study evaluated the effect of topical administration of ointment containing dill (Anethum graveolens) essential oil (DEO) in the management of apoptosis and cell proliferation during MRSA-infected experimentally induced wound healing process in BALB/c mice model. The GC-FID and GC-MS techniques were used to analyze chemical composition of the essential oil. Read More

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January 2019
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Potential phytochemicals in the fight against skin cancer: Current landscape and future perspectives.

Biomed Pharmacother 2019 Jan 12;109:1381-1393. Epub 2018 Nov 12.

Department of Chemistry and Chemical Engineering, SBA School of Science and Engineering, Lahore University of Management Sciences (LUMS), DHA, Lahore, Pakistan.

Skin cancer is a life threatening disease and their prevalence and risk has been increasing over the past three decades causing significant loss to human health worldwide. Mostly skin cancer has developed resistance against chemotherapy and radiotherapy. Therefore, development of novel, cost effective and efficient treatment methods are needed. Read More

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January 2019
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Dysregulation of key microRNAs in pancreatic cancer development.

Biomed Pharmacother 2019 Jan 6;109:1008-1015. Epub 2018 Nov 6.

Department of Pathology, Faculty of Veterinary Medicine, University of Tabriz, 51665-1647, Tabriz, Iran. Electronic address:

Pancreatic cancer (PC) is mentioned as one of the fourth major cause of cancer-related deaths and also is considered as one of the most malignancies worldwide. Sadly, widely metastasis is frequently observed at the time of PC detection and there are, thereby, almost poor prognosis and ineffective treatment in PC patients. microRNAs (miRNAs), a group of short non-coding RNAs, regulate various cellular and developmental mechanisms, such as cell growth, proliferation, apoptosis, differentiation and angiogenesis. Read More

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January 2019
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Apigenin Suppresses Angiogenesis by Inhibiting Tube Formation and Inducing Apoptosis.

Nat Prod Commun 2016 Oct;11(10):1433-1436

Apigenin has been reported to exert angiogenic and anticancer activities in vitro. The mechanism of inhibition of angiogenesis by apigenin, however, has not been well-established. In this study, we investigated whether apigenin not only inhibited tube formation but also induced apoptosis in human umbilical vein endothelial cells (HUVECs). Read More

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October 2016

Association of Upregulated Angiogenic Cytokines With Choroidal Abnormalities in Chronic Central Serous Chorioretinopathy.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5924-5931

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Purpose: To clarify the distinct molecular pathogenesis of central serous chorioretinopathy (CSC) and pachychoroid neovasculopathy (PNV).

Methods: Aqueous humor (AH) was collected from 18 acute CSC, 20 chronic CSC, and 20 PNV patients. Concentrations of 30 cytokines in the AH were analyzed using a multiplex bead immunoassay, and the cytokine profiles were compared among these three groups of patients. Read More

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December 2018

Self-Assembled GFFYK Peptide Hydrogel Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells in a Mouse Hindlimb Ischemia Model.

Acta Biomater 2018 Dec 11. Epub 2018 Dec 11.

Nankai University School of Medicine, Tianjin 300071, China; The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, The College of Life Science, Tianjin 300071, China. Electronic address:

Mesenchymal stem cell (MSC) transplantation has emerged as a very promising strategy for the treatments of peripheral artery disease (PAD). However, MSC-based therapies are limited by low cell retention and survival rate in the ischemic zone. Small molecular (SM) hydrogels have shown attractive abilities to enhance the therapeutic effects of human MSCs via promoting their proliferation or maintaining their differentiation potential. Read More

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December 2018
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miRNA networks modulate human endothelial cell adaptation to cyclic hypoxia.

Cell Signal 2018 Dec 11. Epub 2018 Dec 11.

Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk, Poland. Electronic address:

Solid tumor microenvironments are often subjected to various levels of hypoxia. Although regulation of gene expression has been examined extensively, most studies have focused on prolonged hypoxia. The tumor microenvironment, however, experiences waves of hypoxia and reoxygenation that stimulate the expression of pro-angiogenic factors that promote blood vessel formation. Read More

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December 2018
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[Progress in the study of artemisinin and its derivatives against head and neck cancer].

Authors:
Y Z Liang X L Nong

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1519-1523

The head and neck cancer is one of the most common malignant tumors in the world. There are more than 600 000 new cases in the world every year. Cisplatin is often used in the treatment of head and neck cancer at present. Read More

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October 2018
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Live Confocal Visualization of FXIII Activity.

Clin Lab 2018 Oct;64(11)

In addition to its important functions in angiogenesis, wound healing, bone biology, immunology, pregnancy, and adipogenesis, transglutaminase factor XIII is an outstanding determinant of clot characteristics. Factor XIII mediates clot stability by covalent cross-linking of fibrin-fibrils and inhibition of fibrinolysis. For decades it was assumed that factor XIII mediates the formation of a 3-dimensional net structure of the clot. Read More

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October 2018

Early immune biomarkers and intermediate-term outcomes after heart transplant: Results of Clinical Trials in Organ Transplantation-18.

Am J Transplant 2018 Dec 14. Epub 2018 Dec 14.

Cleveland Clinic Cleveland OH, USA.

Clinical Trials in Organ Transplantation-18 (CTOT-18) is a follow-up analysis of the 200-subject multicenter heart transplant CTOT-05 cohort. CTOT-18 aimed to identify clinical, epidemiological and biological markers associated with adverse clinical events past 1 year after transplant. We examined various candidate biomarkers including serum antibodies, angiogenic proteins, blood gene expression profiles and T-cell alloreactivity. Read More

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December 2018
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LncRNAs in Cancer: another layer of complexity.

J Gene Med 2018 Dec 14:e3065. Epub 2018 Dec 14.

Department of Genetics, Federal University of Parana, Brazil.

Aims: This article aims to review the most well characterized lncRNAs with important roles in hallmarks of cancer, additionally including lncRNAs with higher potential for clinical application.

Discussion: LncRNAs are transcripts larger than 200 nucleotides in length that do not appear to have protein-coding potential, although some of those may produce small functional peptides. These transcripts have attracted significant attention of researchers due to their role in genetic regulation including epigenetic, transcriptional, and post-transcriptional regulation, being involved in numerous biological processes as well as being associated with multifactorial diseases, including tumorigenesis. Read More

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December 2018
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Angiogenin production in response to hypoxia and l-mimosine in periodontal fibroblasts.

J Periodontol 2018 Dec 14. Epub 2018 Dec 14.

Department of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Background: A major mediator of angiogenesis is angiogenin which is expressed in the early phase of healing in oral tissue engineering strategies. It is unclear how angiogenin is regulated in the periodontal tissue. The objective of this study was to reveal the regulation of angiogenin in response to hypoxia and the hypoxia mimetic agent L-mimosine in periodontal fibroblasts METHODS: Human fibroblasts of the periodontal ligament (PDLF) and the gingiva (GF) in monolayer and spheroid cultures were exposed to hypoxia or L-mimosine. Read More

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December 2018

Curcumin: A new candidate for retinal disease therapy?

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

The retina is the neural portion and light-sensitive layer of the eye, which has been observed in most of the vertebrates. The retina is composed of light-sensitive cells that absorb light and convert it into neural signals. These signals are sent to the brain for visual recognition. Read More

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December 2018
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In Vivo Choroidal Neovascularization and Macrophage Studies Provide Further Evidence for a Broad Role of Prostacyclin in Angiogenesis.

J Ocul Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Department of Biological Sciences, Allergan, Inc. , Irvine, California.

Purpose: The purpose of these studies was (1) to investigate the ability of human M1 phenotype macrophages to secrete vascular endothelial growth factor (VEGF) and the influence of prostacyclin receptor (IP) stimulation (2) to evaluate the contribution of the proangiogenic prostanoid prostacyclin to experimental choroidal neovascularization Methods: Human macrophages derived from primary blood mononuclear cells were functionally biased toward the M1 phenotype by using tumor necrosis factor α (TNFα). Experimental choroidal neovascularization was produced by laser photocoagulation. Antagonist drugs RO-3244794 (IP antagonist) and GW 627368 (EP antagonist) were administered according to an optimal dosing regimen that was predetermined by bioavailability studies. Read More

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December 2018

Melanoma tumour vasculature heterogeneity: from mice models to human.

J Cancer Res Clin Oncol 2018 Dec 13. Epub 2018 Dec 13.

UMR Inserm 1066, CNRS 6021, Université d'Angers, CHU, IBS, IRIS, MINT, UNIV Angers, INSERM, CNRS, Université Bretagne Loire, IBS-CHU, 4, rue Larrey, 49933, Angers, France.

Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of this study was to compare and to characterize the tumour vascular structure in different mouse models of melanoma tumours (B16F10 and SK-Mel-28) and in human melanomas from different patients. Read More

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December 2018
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Contribution of IL-33 to the Pathogenesis of Colorectal Cancer.

Front Oncol 2018 28;8:561. Epub 2018 Nov 28.

Department of Gastroenterology, University Hospital of North Norway, Tromsø, Norway.

The development of colorectal cancer (CRC) is not only determined by transformed cells , but also by factors existing in their immune microenvironment. Accumulating scientific evidence has revealed that interleukin (IL)-33, an IL-1 family member, plays an essential role in the regulation of immune response and is relevant in CRC pathogenesis. Data from both human and experimental studies demonstrated that IL-33 inhibits host anti-tumor immunity, remodels tumor stroma and enhances angiogenesis, thereby promoting the development of CRC. Read More

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November 2018

Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives.

Front Oncol 2018 28;8:552. Epub 2018 Nov 28.

DAILAB, DBT-AIST International Center for Translational and Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology, Tsukuba, Japan.

We had previously reported anticancer activity in the water extract (WEX) of Ashwagandha leaves, and identified Triethylene glycol (TEG) as an active tumor suppressor component. In this study, we investigated anti-migratory and anti-angiogenesis activities of WEX and TEG. We conducted and experiments using TEG, and its two derivatives, Triethyleneglycol dimethacrylate (TD-10), and Tetraethyleneglycol dimethacrylate (TD-11). Read More

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November 2018

The role of CMV in glioblastoma and implications for immunotherapeutic strategies.

Oncoimmunology 2019 16;8(1):e1514921. Epub 2018 Oct 16.

Lillian S. Wells Department of Neurosurgery, UF Brain Tumor Immunotherapy Program, Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL, USA.

Controversy surrounds the role of cytomegalovirus (CMV) in glioblastoma (GBM). However, several studies have shown that CMV nucleic acids and proteins are present within GBM tumor tissue. CMV has been implicated in GBM pathogenesis by affecting tumor stem cell factors, angiogenesis and immune pathways. Read More

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October 2018
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The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension.

Oncotarget 2018 Nov 16;9(90):36220-36237. Epub 2018 Nov 16.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Background And Aims: Angiogenesis is critically involved in the development of liver fibrosis, portal hypertension (PHT) and hepatocellular carcinoma (HCC). Regorafenib is a novel second-line therapy for HCC, but might also be beneficial in fibrosis and PHT even in absence of HCC. This study investigated the effects of regorafenib in experimental models without HCC. Read More

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November 2018

Long non-coding RNA LINC01410 promotes colon cancer cell proliferation and invasion by inhibiting miR-3128.

Exp Ther Med 2018 Dec 28;16(6):4824-4830. Epub 2018 Sep 28.

Department of Nursing, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan 423000, P.R. China.

A previous study implied that long intergenic non-coding RNA 1410 (LINC01410) promotes angiogenesis and metastasis of gastric cancer. However, the role of LINC01410 in colon cancer (CC) has remained elusive. In the present study, LINC01410 was identified to be highly expressed in CC tissues compared to adjacent normal tissues. Read More

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December 2018

Evaluation of mast cells in oral premalignant and malignant lesions: A histochemical study.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):184-190

Department of Oral Medicine and Radiology, Pacific Dental College, Udaipur, Rajasthan, India.

Introduction: Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Read More

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December 2018

Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway.

EBioMedicine 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.. Electronic address:

Background: We previously found that loss of lncRNA-AZIN2 splice variant (AZIN2-sv) increases cardiomyocyte (CM) proliferation and attenuates adverse ventricular remodelling post-myocardial infarction (MI). However, whether inhibition of AZIN2-sv can simultaneously induce angiogenesis and thus improve prognosis after MI is unclear.

Methods: We used in situ hybridization and quantitative PCR to determine AZIN2-sv expression in endothelial cells. Read More

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December 2018

Measurement of vascularity in the scar: A systematic review.

Burns 2018 Dec 10. Epub 2018 Dec 10.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. Electronic address:

Background: Vascularity is an important parameter closely associated with the scar maturation. Reliable and accurate measurement of vascularity helps to monitor the scar change and adopt targeted interventions to prevent excessive scarring and achieve promising outcomes. However, there is no consensus on the assessment tools for the vascularity measurement in scars. Read More

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December 2018

Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins.

J Clin Med 2018 Dec 11;7(12). Epub 2018 Dec 11.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.

Lower extremities varicose veins (VV) are among the most easily recognized venous abnormalities. The genetic mechanism of VV is largely unknown. In this study, we sought to explore the global expressional change of VV and identify novel genes that might play a role in VV. Read More

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December 2018

Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis.

Int J Mol Sci 2018 Dec 11;19(12). Epub 2018 Dec 11.

Dipartimento della Ricerca e della Diagnostica Avanzata dei Tumori, Divisione di Oncologia Molecolare, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.

Gastric cancer is a deadly tumor and a relatively common disease worldwide. Surgical resection and chemotherapy are the main clinical options to treat this type of disease, however the median overall survival rate is limited to one year. Thus, the development of new therapies is a highly necessary clinical need. Read More

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December 2018

Microparticles Carrying Sonic Hedgehog Are Increased in Humans with Peripheral Artery Disease.

Int J Mol Sci 2018 Dec 9;19(12). Epub 2018 Dec 9.

Department of Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Sonic hedgehog (Shh) is a prototypical angiogenic agent with a crucial role in the regulation of angiogenesis. Experimental studies have shown that Shh is upregulated in response to ischemia. Also, Shh may be found on the surface of circulating microparticles (MPs) and MPs bearing Shh (Shh + MPs) have shown the ability to contribute to reparative neovascularization after ischemic injury in mice. Read More

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December 2018

Epigenetic Targeting of Autophagy via HDAC Inhibition in Tumor Cells: Role of p53.

Int J Mol Sci 2018 Dec 8;19(12). Epub 2018 Dec 8.

Department of Cranio-Maxillofacial Surgery, University of Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany.

Tumor development and progression is the consequence of genetic as well as epigenetic alterations of the cell. As part of the epigenetic regulatory system, histone acetyltransferases (HATs) and deacetylases (HDACs) drive the modification of histone as well as non-histone proteins. Derailed acetylation-mediated gene expression in cancer due to a delicate imbalance in HDAC expression can be reversed by histone deacetylase inhibitors (HDACi). Read More

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December 2018

Antimetastatic and antiangiogenic activity of trabectedin in cutaneous melanoma.

Carcinogenesis 2018 Dec 13. Epub 2018 Dec 13.

Tumor Angiogenesis Unit, Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.

Trabectedin is a marine-derived anti-neoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor microenvironment with marked effects on the vasculature and the immune response. Since a favorable microenvironment is a key factor in the progression of cutaneous melanoma, we hypothesized that trabectedin might affect the growth and metastasis of this highly aggressive cancer. Read More

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December 2018

Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis.

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Division of Rheumatology, Department of Medicine, University of Debrecen, Faculty of Medicine, Debrecen, Hungary. Electronic address:

Several inflammatory, proteolytic, angiogenic and bone-associated factors play a role in the development of autoimmune, accelerated atherosclerosis in rheumatic diseases. Some of these may serve as biomarkers of vascular pathology and may be useful in the follow-up of vascular damage and outcome. Multi-biomarker profiles rather than a single markers would likely be optimal in this respect. Read More

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December 2018

Plasma levels of VEGF-A, VEGF B, and VEGFR-1 and applicability of these parameters as tumor markers in diagnosis of breast cancer.

Acta Biochim Pol 2018 Dec 13. Epub 2018 Dec 13.

Medical University of Bialystok.

The VEGF family members are important factors in promoting angiogenesis and lymphangiogenesis in malignant processes. The aim of this study was to investigate plasma concentrations of VEGF-A, VEGF-B and their soluble VEGFR-1 receptor and their diagnostic utility and potency as compared to CA 15-3 in breast cancer patients and in relation to the control group. The study included 120 breast cancer patients and 60 control patients. Read More

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December 2018
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Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Cardiac tissue engineering (CTE) remains a great challenge to construct a cell-inductive scaffold which has positive effects on cardiac cell behaviors and cardiac tissue repair. In this study, we for the first time demonstrated that Si ions evidently stimulated the expression of cardiac specific genes and proliferation of neonatal rat cardiomyocytes (NRCMs) at concentration ranges of 0.13 ~ 10. Read More

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December 2018

Vascular responses of aortic, renal, and uterine arteries in suramin-induced preeclampsia-like syndrome in rats

Turk J Med Sci 2018 12 12;48(6):1328-1339. Epub 2018 Dec 12.

Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy. We aimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic, renal, and uterine arteries.

Materials And Methods: Pregnant and nonpregnant wistar rats received suramin (100 mg/kg, intraperitoneal) or equal volume of saline on days 10 and 11. Read More

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December 2018

Intrauterine Inflammation Damages Placental Angiogenesis via Wnt5a-Flt1 Activation.

Inflammation 2018 Dec 12. Epub 2018 Dec 12.

Department of Neonatology, Guangdong Women and Children Hospital, Guang Zhou Medical University, Guangzhou, 510010, Guangdong, China.

Intrauterine inflammation is the main reason for neonatal adverse outcomes and normal placenta perfusion plays an important role in fetal development. However, whether inflammation will affect placental angiogenesis and the underlying mechanism are still poorly understood. To investigate lipopolysaccharide (LPS)-induced intrauterine inflammation on placenta angiogenesis and Wnt5a-Flt1 expression. Read More

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December 2018

Mesenchymal Stem Cells as Regulators of Carcinogenesis.

Adv Exp Med Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, İstanbul, Turkey.

Mesenchymal Stem Cells (MSCs) are adult stem cells; isolated from various body parts including bone marrow, adipose tissue and dental tissue, have been characterized well and used in regenerative medicine applications. The promising potential of MSCs makes them great candidates in many disorders. It has been well known in the literature that MSCs interact with cancer cells and regulate the carcinogenesis process at different stages. Read More

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December 2018

Anoikis‑resistant human osteosarcoma cells display significant angiogenesis by activating the Src kinase‑mediated MAPK pathway.

Oncol Rep 2018 Oct 29. Epub 2018 Oct 29.

Department of Pathology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P.R. China.

Tumor cells must resist anoikis to metastasize. There is a key role of angiogenesis in the growth and metastasis of tumors. However, the relationship between anoikis resistance and angiogenesis has not been well explored in human osteosarcoma. Read More

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October 2018

Cellular communication promotes mammosphere growth and collective invasion through microtubule‑like structures and angiogenesis.

Oncol Rep 2018 Oct 9. Epub 2018 Oct 9.

Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

Networks of nanotubes and microtubules are highly valued in cellular communication, and collective cancer movement has been revealed to be associated with cell information exchange. In the present study, cellular communication was demonstrated to participate in mammosphere growth, differentiation and collective invasion. By promoting differentiation, networks of cells and microtubule‑like structures were verified. Read More

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October 2018

Fascin is involved in cancer cell invasion and is regulated by stromal factors.

Oncol Rep 2018 Nov 2. Epub 2018 Nov 2.

Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam, Gyunggi‑Do 13135, Republic of Korea.

The tumor microenvironment plays an important role in cancer growth, invasion and metastasis. The stroma surrounding a tumor is known to contain a variety of factors that can increase angiogenesis, cancer growth and tumor progression. The aim of the present study was to determine the role of fascin in cancer growth and invasion and identify stromal factors involved in cancer progression. Read More

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November 2018