3D endothelial cell spheroid/human vitreous humor assay for the characterization of anti-angiogenic inhibitors for the treatment of proliferative diabetic retinopathy.
- Sara Rezzola,
- Imtiaz M Nawaz,
- Anna Cancarini,
- Cosetta Ravelli,
- Stefano Calza,
- Francesco Semeraro,
- Marco Presta
Angiogenesis 2017 Sep 13. Epub 2017 Sep 13.
Department of Molecular and Translational Medicine, University of Brescia, viale Europa 11, 25123, Brescia, Italy.
Proliferative diabetic retinopathy (PDR) represents a main cause of acquired blindness. Despite the recognition of the key role exerted by vascular endothelial growth factor (VEGF) in the pathogenesis of PDR, limitations to anti-VEGF therapies do exist. Thus, rapid and cost-effective angiogenesis assays are crucial for the screening of anti-angiogenic drug candidates for PDR therapy. Read More