Search Our Scientific Publications & Authors

Dermatol Online J 2021 Mar 15;27(3). Epub 2021 Mar 15.

Department of Dermatology, University of Florida College of Medicine, Gainesville, FlL.

Reactive angioendotheliomatosis (RAE) is an uncommon, benign, antiproliferative condition associated with systemic diseases that may cause occlusion or inflammation of the vascular lumina. A link between antiphospholipid syndrome (APS) and RAE has been reported a few times in the literature. Herein, we present a unique case of RAE diagnosed in a patient with primary APS who was well-managed on warfarin and rituximab with no recent thrombotic events. Read More

Am J Med 2021 Feb 25. Epub 2021 Feb 25.

Division of Pulmonary and Critical Care Medicine. Electronic address:

Background: Intrathoracic involvement with lymphomas is common and manifests lymphadenopathy as well as a wide spectrum of imaging abnormalities in the lungs. Intravascular large B-cell lymphoma (IVLBCL) is a rare extranodal subtype of large B-cell lymphoma that typically involves small blood vessels and is difficult to detect.

Methods: Using a computer-assisted search, we identified patients with histopathologically proven IVLBCL in the lungs at Mayo Clinic from 2001 through 2018. Read More

JAAD Case Rep 2021 Feb 17;8:56-59. Epub 2020 Dec 17.

Dermatology Clinic, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Vet Pathol 2020 Dec 11:300985820980707. Epub 2020 Dec 11.

Cornell University, Ithaca, NY, USA.

In disease, blood vessel proliferation has many salient roles including in inflammation, when granulation tissue fills superficial defects, or in the recanalization of an occluded blood vessel. Sometimes angiogenesis goes awry-granulation can be exuberant, and plexiform proliferation of vascular components can contribute to pulmonary hypertension. This review focuses on the diverse manifestations of pathologic vascular overgrowth that occur in the brain, spinal cord, and meninges of animals from birth until old age. Read More

JAAD Case Rep 2020 Dec 20;6(12):1228-1230. Epub 2020 Sep 20.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Pathology 2021 Feb 16;53(2):273-276. Epub 2020 Oct 16.

Duke-NUS Medical School, Singapore.

J Eur Acad Dermatol Venereol 2021 Feb 17;35(2):e115-e118. Epub 2020 Aug 17.

Dermatology Department, Université Côte d'Azur, CHU Nice, Nice, France.

Proc (Bayl Univ Med Cent) 2020 Jul 21;33(3):419-421. Epub 2020 May 21.

Department of Dermatology, Baylor Scott & White Medical Center - TempleTempleTexas.

Diffuse dermal angiomatosis is a rare, benign, reactive cutaneous vascular disorder considered to be a distinct variant of reactive angioendotheliomatosis. The disease typically presents in obese patients who smoke and have atherosclerotic risk factors, vasculopathies, or other comorbidities associated with hypoxemia. We present a case of a 40-year-old woman with ulcerated plaques on her abdomen consistent with diffuse dermal angiomatosis on histopathological evaluation. Read More

Am J Dermatopathol 2021 Feb;43(2):119-136

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain; and.

Abstract: Intravascular proliferations of the skin are clinically heterogeneous and may present with a wide range of clinical features, including violaceous papules, nodules, plaques, or other unspecific cutaneous lesions. Histopathologically, these conditions are characterized by proliferation of different cell types within the lumina of dermal vessels and endothelial cell hyperplasia. Immunohistochemistry is the best tool to identify the nature of the intravascular proliferating cells and the type of involved vessel. Read More

Acta Derm Venereol 2020 Jul 2;100(14):adv00202. Epub 2020 Jul 2.

Department of Dermatology-Venereology, Hôpital Robert Debré, FR-51100 Reims, France. E-mail:

Dermatol Ther 2020 07 5;33(4):e13587. Epub 2020 Jun 5.

Department of Dermatology, University Hospital Basel, Basel, Switzerland.

Dehydrated human amnion/chorion membrane allograft (dHACM) derived from placenta is increasingly used for skin and soft tissue repair in several medical specialties. Promising effects of dHACM were also reported in chronic venous and diabetic leg ulcers. However, dHACM is cost-intensive and its effect on chronic leg ulcers of other etiologies and pain reduction is unknown. Read More

J Cutan Pathol 2021 Jun 20;48(6):725-729. Epub 2021 Jan 20.

Department of Dermatology, Fundación Instituto Valenciano de Oncología, Valencia, Spain.

Pathology 2020 06 25;52(4):494-496. Epub 2020 Apr 25.

Halbert Dermatology, Nedlands, WA, Australia.

Proc (Bayl Univ Med Cent) 2020 Apr 6;33(2):273-275. Epub 2020 Feb 6.

Division of Dermatology, Baylor Scott & WhiteDallasTexas.

Diffuse dermal angiomatosis of the breast can be a painful, irritating, and persistent inflammatory condition. It tends to present in middle age and is associated with a number of risk factors, mainly relating to tissue hypoxia. There are no standard treatment guidelines, and current treatment focuses on mitigating tissue hypoxia by addressing atherosclerosis through lifestyle changes and medical and/or surgical intervention. Read More

Cureus 2020 Feb 11;12(2):e6955. Epub 2020 Feb 11.

Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA.

Cutaneous tender tumors manifest as painful dermal or subcutaneous masses. Acronyms, a memory aid created from the initial letters of other words, can be used to assist in recalling a list of conditions. We report the case of a man who presented with a painful lesion on his leg; 15 years earlier, hot solder had embedded beneath his skin at that location. Read More

Clin Cosmet Investig Dermatol 2019 13;12:123-132. Epub 2019 Feb 13.

Compass Dermatopathology, San Diego, CA, USA.

Painful tumors of the skin present as dermal or subcutaneous nodules. They can originate from several sources: adipose tissue, cartilage degeneration, deposition of bone or calcium, eccrine glands, fibrous tissue, infiltration of benign (endometrium) or malignant (metastatic neoplasm) tissue, muscle, nerve, or vascular structures. Although pathologic evaluation of the lesion is necessary to determine the diagnosis, it is possible to make a reasonable differential diagnosis based on knowledge of prior tumors that have appeared as tender lesions. Read More

Case Rep Dermatol 2017 Sep-Dec;9(3):194-205. Epub 2017 Oct 13.

Kempf und Pfaltz Histologische Diagnostik, Zurich, Switzerland.

Diffuse dermal angiomatosis (DDA) is a rare reactive angioproliferation in the skin and considered to be a subtype in the group of cutaneous reactive angiomatoses. DDA is clinically characterized by livedoid patches and plaques with tender ulceration. Its histologic features are a reactive diffuse proliferation of bland endothelial cells and pericytes within the dermis, forming small capillary vessels. Read More

J Vasc Access 2018 Jan;19(1):94-97

3 Department Vascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio - USA.

Introduction: Arteriovenous fistulae (AVF)-associated reactive angioendotheliomatosis (RAE) is a very rare entity (three previously reported cases in the literature) that can manifest as extremity wounds. RAE's etiopathology is unknown.

Case Description: We report a case of severe limb-threatening upper extremity wound with pathology-proven RAE. Read More

J Am Acad Dermatol 2017 Dec 3;77(6):1145-1158. Epub 2017 Oct 3.

Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain. Electronic address:

Cutaneous manifestations secondary to paraprotein deposits in the skin include a group of different disorders that although rare, may be the first clinical manifestation of the underlying hematologic dyscrasia. In this article we review the clinical manifestations and histopathologic findings of the processes that result from specific deposition of the paraprotein in different structures of the skin. Paraneoplastic processes frequently associated with hematologic malignancies will not be covered in this review. Read More

Breast J 2018 03 26;24(2):196-198. Epub 2017 Jul 26.

Department of Pathology, Alpert Medical School of Brown University, Providence, RI, USA.

Diffuse dermal angiomatosis (DDA) is a rare pathologically distinct subtype of reactive angioendotheliomatosis. In the literature, few biopsy-proven cases involving breast skin have been reported. We present a case of a 49-year-old female who presented with an indurated, erythematous, weeping, puckered and tender lesion with focal ulceration. Read More

Am J Dermatopathol 2017 Jan;39(1):33-39

*Virginia Tech Carilion Dermatology and Mohs Surgery, Roanoke, VA; and †Cleveland Clinic, Dermatology and Plastic Surgery Institute, Cleveland, OH.

Reactive angioendotheliomatosis (REA) is a rare benign angioproliferative condition of the skin, which has been noted to occur in patients with a variety of underlying systemic diseases. Histopathologically, this condition is characterized by vascular proliferation, and endothelial cell hyperplasia within the lumina and around dermal vessels, without significant cellular atypia. Since the first case of RAE was reported in 1958, multiple histologic patterns of benign cutaneous vascular proliferations with similar clinical presentations to RAE have been described in the literature and have been proposed as subtypes of the originally described condition. Read More

J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 2):39-43

Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA.

A 70-year-old Caucasian male presented to our clinic for a pruritic eruption progressing over several months. He complained of fatigue with a 20-pound weight loss over the past year. On presentation, the patient had browny-yellow to violaceous, purpuric, macular and papular lesions on the legs, arms, lower abdomen and back. Read More

Vet Radiol Ultrasound 2017 Mar 5;58(2):E16-E21. Epub 2016 May 5.

Department of Pathobiology, Auburn University College of Veterinary Medicine, Auburn, AL 36849.

A 10-year-old, castrated male domestic short-haired cat was presented with an acute history of seizures, lethargy, anorexia, vomiting, and dyspnea. Magnetic resonance imaging of the brain showed multifocal areas of gray matter T2-weighted hyperintensity. The lesions did not enhance with intravenous contrast. Read More

Pathol Res Pract 2016 Apr 31;212(4):258-63. Epub 2015 Dec 31.

Anatomical Pathology Department, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria and IDIVAL, Santander, Spain.

Intravascular histiocytosis (IVH) is a rare condition of uncertain pathogenesis often associated with rheumatoid arthritis (RA) exclusively observed in the skin. In a retrospective study of 207 consecutive cases of aortic valve disease, we observed two cases of IVH characterized by the presence of thin-walled, dilated blood vessels containing collections of CD68+ and CD163+ mononuclear histiocytes. Immunostains for CD31, CD34, and D2-40 confirmed the intravascular location of these histiocytes. Read More

Am J Dermatopathol 2015 Oct;37(10):783-9

*Department of Pathology, I.U. Cerrahpasa Medical Faculty, Istanbul, Turkey; †Department of Pathology, Istanbul Training and Research Hospital; ‡Department of Dermatology, Marmara University; §Department of Dermatology, Istanbul Training and Research Hospital; and ¶Department of Dermatology, I.U. Cerrahpasa Medical Faculty, Istanbul, Turkey.

Intravascular/intralymphatic histiocytosis (IV/ILH) is a rare, reactive cutaneous condition, with uncertain pathogenesis. It may be associated with various inflammatory and neoplastic diseases. Although the clinical presentation is various, the biopsies reveal dilated vessels, mostly lymphatics, containing aggregates of histiocytes within their lumina. Read More

Lupus 2015 Dec 31;24(14):1557-61. Epub 2015 Jul 31.

Krishna Institute of Medical Sciences, Karad, India.

Background: Antiphospholipid antibody syndrome is an autoimmune disorder associated with pregnancy complications, venous and/or arterial thrombosis and the presence of antiphospholipid antibodies. This syndrome is known to present with various cutaneous features, but association with reactive angioendotheliomatosis has been described rarely in the literature.

Results: A woman in her thirties with a past history of three consecutive abortions developed purpuric, ulcerative plaque over the plantar aspect of the foot. Read More

Int J Dermatol 2015 Nov 30;54(11):e480-2. Epub 2015 Jul 30.

Department of Pathology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.

Int J Dermatol 2015 Sep 14;54(9):e372-3. Epub 2015 Jul 14.

Department of Dermatology, Second University of Naples, Naples, Italy.

JFMS Open Rep 2015 Jan-Jun;1(1):2055116915579684. Epub 2015 Jun 1.

Syu Syu CAT Clinic, Tokyo, Japan.

A 3-year-old domestic shorthair cat presented with lethargy and anorexia. A blood test showed regenerative anaemia and thrombocytopenia. Thoracic radiographs showed a small amount of pleural effusion. Read More

Am J Dermatopathol 2015 May;37(5):401-4

*Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA; and †Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX. P. P. Aung is currently affiliated to the Department of Pathology and Lab Medicine, UT-MD Anderson Cancer Center, Houston, TX.

Reactive angioendotheliomatosis (RAE) is a rare cutaneous vascular disorder characterized by intravascular hyperplasia of endothelial cells, sometimes with a vascular proliferation. Intravascular histiocytosis (IH) is a similar vascular disorder characterized by the presence of dilated vessels containing aggregates of mononuclear histiocytes (macrophages) within their lumina. Although their pathogenesis remains uncertain, there has been speculation about the possible relationship between IH and RAE. Read More