536 results match your criteria Angioedema Acquired


Macroglossia secondary to lisinopril-induced acute angioedema.

Proc (Bayl Univ Med Cent) 2019 Jan 16;32(1):70-72. Epub 2019 Jan 16.

Department of Oral and Maxillofacial Surgery, Baylor University Medical Center at DallasDallasTexas.

Presented here are two cases of acute acquired macroglossia in adults caused by angioedema resulting from a reaction to angiotensin-converting enzyme inhibitors (ACEIs). Angioedema can be caused by a variety of factors, but ACEIs are the most common precipitating factor. Symptoms such as swelling of the lips, face, tongue, and throat can lead to life-threatening airway compromise. Read More

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https://www.tandfonline.com/doi/full/10.1080/08998280.2018.1
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http://dx.doi.org/10.1080/08998280.2018.1540736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442892PMC
January 2019
3 Reads

Anaesthetic management of patients with pre-existing allergic conditions: a narrative review.

Br J Anaesth 2019 Mar 12. Epub 2019 Mar 12.

Department of Anaesthesia and Peri-operative Medicine, Auckland City Hospital, Auckland, New Zealand.

This narrative review seeks to distinguish the clinical patterns of pre-existing allergic conditions from other confounding non-allergic clinical entities, and to identify the potential related risks and facilitate their perioperative management. Follow-up investigation should be performed after a perioperative immediate hypersensitivity to establish a diagnosis and provide advice for subsequent anaesthetics, the main risk factor for perioperative immunoglobulin E (IgE)-mediated anaphylaxis being a previous uninvestigated perioperative immediate hypersensitivity reaction. The concept of cross-reactivity between drugs used in the perioperative setting and food is often quoted, but usually not supported by evidence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912193006
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http://dx.doi.org/10.1016/j.bja.2019.01.020DOI Listing
March 2019
7 Reads

Reporting through smartphone application results in detailed data on acquired and hereditary angioedema attacks.

Allergy 2019 Mar 25. Epub 2019 Mar 25.

HAE Centre Denmark, Odense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.1111/all.13792DOI Listing
March 2019
1 Read

Angioedema due to acquired C1-inhibitor deficiency: spectrum and treatment with C1-inhibitor concentrate.

Orphanet J Rare Dis 2019 Mar 13;14(1):65. Epub 2019 Mar 13.

Department of Medical Psychology and Medical Sociology, Johannes Gutenberg University, Mainz, Germany.

Background: Acquired angioedema due to C1-inhibitor (C1-INH) deficiency (AAE-C1-INH) is a serious condition that may result in life-threatening asphyxiation due to laryngeal edema. It is associated with malignant B-cell lymphoma and other disorders. The purpose of this study was to describe the characteristics and associated disorders of patients with AAE-C1-INH and assess the efficacy of plasma-derived C1-INH concentrate (pdC1-INH) in the treatment of AAE-C1-INH. Read More

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http://dx.doi.org/10.1186/s13023-019-1043-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417199PMC
March 2019
2 Reads

Identification of the recently described plasminogen gene mutation p.Lys330Glu in a family from Northern Germany with hereditary angioedema.

Clin Transl Allergy 2019 14;9. Epub 2019 Feb 14.

1Department of Dermatology, Allergology and Venereology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.

Hereditary angioedema (HAE) is a life-threatening disease characterized by recurrent episodes of subcutaneous and mucosal swellings and abdominal cramping. Corticosteroids and antihistamines, which are usually beneficial in histamine-induced acquired angioedema, are not effective in HAE. Therefore, diagnosing HAE correctly is crucial for affected patients. Read More

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http://dx.doi.org/10.1186/s13601-019-0247-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374890PMC
February 2019
2 Reads

Isolated angioedema: An overview of clinical features and etiology.

Exp Ther Med 2019 Feb 16;17(2):1068-1072. Epub 2018 Nov 16.

Allergology and Immunology Discipline, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania.

Angioedema can occur in isolation, accompanied by urticaria, or as a feature of anaphylaxis in mast cell-mediated disorders, bradykinin-mediated disorders, as well as in others with unknown mechanisms, such as infections, rare disorders, or idiopathic angioedema. In mast cell-mediated angioedema, other signs and symptoms of mast cell-mediator release are frequently seen. However, clear evidence of mast cell degranulation may be absent in histaminergic angioedema. Read More

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http://dx.doi.org/10.3892/etm.2018.6982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327642PMC
February 2019
2 Reads

[Age-specific aspects in the treatment of angioedema patients].

Authors:
P Staubach

Hautarzt 2019 Feb;70(2):101-106

Spezialsprechstunde Angioödeme, Hautklinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.

Manifestation of angioedema can occur at any age. We distinguish between two main subtypes: mast cell mediator-associated angioedema (often with hives) and the non-mast cell mediator-associated angioedema. The patient's history is very important due to the fact that one subtype can be hereditary, but we also have to consider new mutations and even not yet diagnosed patients. Read More

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http://dx.doi.org/10.1007/s00105-018-4346-8DOI Listing
February 2019
3 Reads

Melkersson-Rosenthal syndrome: a case report of a rare disease with overlapping features.

Allergy Asthma Clin Immunol 2019 5;15. Epub 2019 Jan 5.

2Department of Neuroscience, Division of Dentistry, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-018-0316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320604PMC
January 2019
9 Reads

Diagnosis of solitary extramedullary plasmacytoma located in the nasopharynx in a patient with acquired angioedema.

Postepy Dermatol Alergol 2018 Dec 13;35(6):636-637. Epub 2018 Nov 13.

Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.

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http://dx.doi.org/10.5114/ada.2018.77616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320481PMC
December 2018
2 Reads

CpaA Is a Glycan-Specific Adamalysin-like Protease Secreted by Acinetobacter baumannii That Inactivates Coagulation Factor XII.

MBio 2018 12 18;9(6). Epub 2018 Dec 18.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

Antibiotic-resistant is increasingly recognized as a cause of difficult-to-treat nosocomial infections, including pneumonia, wound infections, and bacteremia. Previous studies have demonstrated that the metalloprotease CpaA contributes to virulence and prolongs clotting time when added to human plasma as measured by the activated partial thromboplastin time (aPTT) assay. Here, we show that CpaA interferes with the intrinsic coagulation pathway, also called the contact activation system, in human as well as murine plasma, but has no discernible effect on the extrinsic pathway. Read More

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http://dx.doi.org/10.1128/mBio.01606-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299215PMC
December 2018
8 Reads

Long-term effects upon rituximab treatment of acquired angioedema due to C1-inhibitor deficiency.

Allergy 2019 Apr 18;74(4):834-840. Epub 2018 Dec 18.

Clinical Immunology and Allergy, Royal National Throat Nose and Ear Hospital, University College London Hospitals, London, UK.

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http://dx.doi.org/10.1111/all.13686DOI Listing
April 2019
2 Reads

Chronic Spontaneous Urticaria or Autoinflammatory Disease? The Therapeutic Effect of Omalizumab in a Pediatric Patient.

J Dermatolog Treat 2018 Nov 14:1-7. Epub 2018 Nov 14.

a 1 University Department Pro.Sa.M.I. "G. D'Alessandro", University of Palermo , Italy.

Chronic spontaneous urticaria is a clinical condition characterized by spontaneous or inducible recurrent wheals. This condition may significantly affect quality of life of patients and of their families. Aetiology is not identified in 25-85% of cases that are indicated as "idiopathic", because all diagnostic tests are negative. Read More

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http://dx.doi.org/10.1080/09546634.2018.1543845DOI Listing
November 2018
4 Reads

Diagnostic biologique des angioedèmes bradykiniques : les recommandations du CREAK.

Presse Med 2019 Jan 8;48(1 Pt 1):55-62. Epub 2018 Nov 8.

Centre de référence national des angioedèmes (CREAK), 38043 Grenoble, France; Service d'immunologie, CHUGA, 38043 Grenoble, France.

Bradykinin mediated angioedema (BK-AE) can be associated either with C1Inhibitor deficiency (hereditary and acquired forms), either with normal C1Inh (hereditary form and drug induced AE as angiotensin converting enzyme inhibitors…). In case of high clinical suspicion of BK-AE, C1Inh exploration must be done at first: C1Inh function and antigenemy as well as C4 concentration. C1Inh deficiency is significant if the tests are below 50 % of the normal values and controlled a second time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07554982183032
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http://dx.doi.org/10.1016/j.lpm.2018.06.015DOI Listing
January 2019
9 Reads

Lethal manifestations of angioedema.

Forensic Sci Med Pathol 2018 Nov 3. Epub 2018 Nov 3.

Forensic Science SA, 21 Divett Place, Adelaide, 5000, Australia.

An 86-year-old woman with a history of angioedema was found dead at her home address. She had recently complained of a swollen tongue. At autopsy the tongue was grossly edematous, protruding from the mouth. Read More

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http://link.springer.com/10.1007/s12024-018-0045-0
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http://dx.doi.org/10.1007/s12024-018-0045-0DOI Listing
November 2018
8 Reads

Nine year follow-up of a rare case of angioedema due to acquired C1-inhibitor deficiency with late onset and good response to attenuated androgen.

Allergy Asthma Clin Immunol 2018 25;14:69. Epub 2018 Oct 25.

1Carol Davila University of Medicine and Pharmacy, Bulevardul Eroii Sanitari, no. 8, District 5, 050474 Bucharest, Romania.

Background: Angioedema due to acquired deficiency of C1-inhibitor (C1-INH-AAE) is a rare disease sharing some clinical and laboratory similarities with hereditary angioedema, but with late onset and no positive family history. The underlining cause may be malignant or due to autoimmune diseases, but some cases remain idiopathic.

Case Presentation: We report a case of a 75 year old woman suffering from recurrent episodes of angioedema since the age of 66, considered first induced by treatment with angiotensin-converting-enzyme inhibitors (ACEI). Read More

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http://dx.doi.org/10.1186/s13223-018-0274-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201569PMC
October 2018
6 Reads

Deletions in SERPING1 Lead to Lower C1 Inhibitor Function: Lower C1 Inhibitor Function Can Predict Disease Severity.

Int Arch Allergy Immunol 2019;178(1):50-59. Epub 2018 Oct 2.

Division of Allergy and Immunology, Department of Internal Medicine, Ege University Faculty of Medicine, Izmir, Turkey.

Background: How genotype affects phenotype in hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) has not been totally clarified. In this study, we investigated the relationship between different types of mutations and various phenotypic characteristics.

Methods: Clinical data from 81 patients from 47 families were recorded. Read More

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http://dx.doi.org/10.1159/000492583DOI Listing
April 2019
6 Reads

Urticaria and angioedema.

Allergy Asthma Clin Immunol 2018 12;14(Suppl 2):59. Epub 2018 Sep 12.

3Section of Allergy & Clinical Immunology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB Canada.

Urticaria (hives) is a common disorder that often presents with angioedema (swelling that occurs beneath the skin). It is generally classified as acute or chronic. Second-generation, non-sedating, non-impairing histamine type 1 (H1)-receptor antihistamines represent the mainstay of therapy for both acute and chronic urticaria. Read More

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http://dx.doi.org/10.1186/s13223-018-0288-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157046PMC
September 2018
8 Reads

THE JEREMIAH METZGER LECTURE NOVEL THERAPEUTIC STRATEGIES OF ALLERGIC AND IMMUNOLOGIC DISORDERS.

Trans Am Clin Climatol Assoc 2018 ;129:250-265

NEW YORK, NEW YORK.

Advances in understanding the immunological basis and mechanisms underlying allergic and immunologic disorders have led to effective but costly long-term and repetitive biologic therapies. Gene therapy is a rapidly advancing technology, in which a single administration of an adeno-associated virus encoding the therapeutic protein or monoclonal antibody may provide effective long-term therapy for allergic and immunologic disorders. In this review, we summarize the recent studies from our laboratory developing gene therapy strategies to treat hereditary angioedema and peanut allergy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116601PMC
December 2018
21 Reads

Omalizumab for Idiopathic Nonhistaminergic Angioedema: Evidence for Efficacy in 2 Patients.

Case Reports Immunol 2018 22;2018:8067610. Epub 2018 Jul 22.

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Presently, there is inconclusive evidence regarding the most effective treatment for idiopathic nonhistaminergic acquired angioedema (InH-AAE). Omalizumab may, however, prove to be a promising option. This case report describes two patients who presented with recurrent angioedema attacks, which was refractory to antihistamine therapy. Read More

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http://dx.doi.org/10.1155/2018/8067610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081528PMC
July 2018
3 Reads

Real-world outcomes in hereditary angioedema: first experience from the Icatibant Outcome Survey in the United Kingdom.

Allergy Asthma Clin Immunol 2018 6;14:28. Epub 2018 Aug 6.

Department of Immunology, Central Manchester University Hospital NHS Foundation Trust, Manchester, UK.

Background: Hereditary angioedema (HAE) is a potentially life-threatening, bradykinin-mediated disease, often misdiagnosed and under-treated, with long diagnostic delays. There are limited real-world data on best-practice management of HAE in the UK.

Objectives: To characterize the clinical profile, management and outcomes of patients with HAE type I and II from three specialist centres in the UK using data from the Icatibant Outcome Survey (IOS; Shire, Zug, Switzerland), an international observational study monitoring safety and effectiveness of icatibant, a selective bradykinin B2 receptor antagonist. Read More

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http://dx.doi.org/10.1186/s13223-018-0253-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091163PMC
August 2018
20 Reads

Splenic marginal zone lymphomas in acquired C1-inhibitor deficiency: clinical and molecular characterization.

Med Oncol 2018 Aug 2;35(9):118. Epub 2018 Aug 2.

Department of Biomedical and Clinical Sciences Luigi Sacco, University of Milan, Luigi Sacco Hospital Milan, Milan, Italy.

Angioedema due to acquired deficiency of the inhibitor of the first component of complement (C1-INH) is a rare disease known as acquired angioedema (AAE). About 70% of patients with AEE display autoantibodies to C1-INH, the remaining patients have no antibodies to C1-INH. The clinical features of C1-INH deficiency include recurrent, self-limiting local swellings involving the skin, the gastrointestinal tract, and the upper respiratory tract. Read More

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http://dx.doi.org/10.1007/s12032-018-1183-7DOI Listing
August 2018
23 Reads

Quantification of human C1 esterase inhibitor protein using an automated turbidimetric immunoassay.

J Clin Lab Anal 2019 Jan 29;33(1):e22627. Epub 2018 Jul 29.

The Binding Site Group Limited, Birmingham, UK.

Background: Impaired levels or function of C1 inhibitor (C1-INH) results in angioedema due to increased bradykinin. It is important to distinguish between angioedema related to C1-INH deficiency and that caused by other mechanisms, as treatment options are different. In hereditary (HAE) and acquired (AAE) angioedema, C1-INH concentration is measured to aid patient diagnosis. Read More

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http://dx.doi.org/10.1002/jcla.22627DOI Listing
January 2019
9 Reads

Angioedema Due to Bradykinin Dysregulation.

J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1132-1141

Department of Medicine, University of California, San Diego, and VA San Diego Healthcare System, San Diego, Calif. Electronic address:

Angioedema is an acute swelling of the deeper layers of the skin or mucosa resulting from a transient increase in vascular permeability. Angioedema can occur in the absence or presence of hives, be hereditary or acquired, and be caused by various potential mediators, including histamine and bradykinin. Bradykinin-mediated angioedema can be difficult to diagnose but is responsible for a disproportionate percentage of the serious morbidity and mortality associated with angioedema. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.04.022DOI Listing
February 2018
21 Reads

Diagnosing Meat Allergy After Tick Bite Without Delay.

J Am Board Fam Med 2018 Jul-Aug;31(4):650-652

From Jersey Shore University Medical Center, Neptune, NJ (ACK, MPC).

Galactose-α-1, 3 galactose (α-gal) is a carbohydrate found in mammalian meat. In 2007, it was implicated as a cause of severe hypersensitivity reactions when a study found elevated levels of antibodies directed against this oligosaccharide among patients treated with cetuximab, a monoclonal antibody that contained an α -gal epitope. The majority of these cases were reported in the Southeast United States in a distribution similar to that of Rocky Mountain spotted fever and ehrlichiosis, and that geographic association led researchers to the conclusion that a bite from the Lone Star tick can induce this antibody. Read More

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http://dx.doi.org/10.3122/jabfm.2018.04.170425DOI Listing
October 2017
10 Reads

Acquired angioedema in juvenile systemic lupus erythematosus: case-based review.

Rheumatol Int 2018 Aug 27;38(8):1577-1584. Epub 2018 Jun 27.

Department of Pediatric of Rheumatology, Pamukkale University School of Medicine, Pamukkale, Denizli, Turkey.

An acquired form of angioedema that is clinically similar but scarcer than the hereditary form may be caused, even more rarely, by the presence of an underlying autoimmune disease. We report a previously healthy 16-year-old girl with an acquired angioedema as a rare and initial presentation of systemic lupus erythematosus. The patient had no previous angioedema attack and no family history. Read More

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http://dx.doi.org/10.1007/s00296-018-4088-zDOI Listing
August 2018
23 Reads

Case report presenting the diagnostic challenges in a patient with recurrent acquired angioedema, antiphospholipid antibodies and undetectable C2 levels.

Allergy Asthma Clin Immunol 2018 4;14:24. Epub 2018 Jun 4.

Western Springs Asthma and Allergy, Western Spring, IL USA.

Background: Angioedema secondary to acquired C1 inhibitor deficiency (AAE) is a rare disease. It usually is associated with lymphoproliferative disorders. We present a case of AAE in a patient with antiphospholipid syndrome (APS), a non-Hodgkin lymphoproliferative disorder (NHL) with undetectable levels of C2, C4, and an undetectable CH50. Read More

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http://dx.doi.org/10.1186/s13223-018-0246-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985567PMC
June 2018
3 Reads

[Tranexamic acid as first-line emergency treatment for episodes of bradykinin-mediated angioedema induced by ACE inhibitors].

Rev Med Interne 2018 Oct 4;39(10):772-776. Epub 2018 May 4.

Service de dermatologie, centre hospitalier Le Mans, 194, avenue Rubillard, 72037 Le Mans, France.

Introduction: Episodes of acquired bradykinin-mediated angioedema due to angiotensin-converting enzyme (ACE) inhibitors may result in fatal outcomes. There is no consensus regarding emergency pharmacological management of these episodes. Treatment options include icatibant and C1INH concentrate. Read More

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http://dx.doi.org/10.1016/j.revmed.2018.04.014DOI Listing
October 2018
1 Read

Quantification of human complement C2 protein using an automated turbidimetric immunoassay.

Clin Chem Lab Med 2018 Aug;56(9):1498-1506

The Binding Site Group Limited, Birmingham, UK.

Background: The measurement of complement components is clinically useful where a deficiency is suspected, or where excessive activation and consumption are present in disease. C2 deficiency carries an increased risk of developing systemic lupus erythematosus, recurrent infections and atherosclerosis. In this study, we have evaluated The Binding Site's Human Complement C2 SPAPLUS® assay. Read More

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http://dx.doi.org/10.1515/cclm-2017-1068DOI Listing
August 2018
5 Reads

Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies.

Orphanet J Rare Dis 2018 05 4;13(1):73. Epub 2018 May 4.

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Bradykinin-mediated angioedema (Bk-AE) can be life-threatening and requires specific targeted therapies. Knowledge of its epidemiology may help optimize its management.

Methods: We systematically searched the medical literature to identify abstracts of interest indexed between 1948 and March, 2016. Read More

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http://dx.doi.org/10.1186/s13023-018-0815-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935942PMC
May 2018
4 Reads

Idiopathic Nonhistaminergic Acquired Angioedema Versus Hereditary Angioedema.

J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1205-1208. Epub 2018 Apr 30.

Hungarian Angioedema Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary. Electronic address:

Background: The mechanism of idiopathic nonhistaminergic acquired angioedema (InH-AAE) has not yet been precisely elucidated. This condition is characterized by recurrent angioedema without wheals.

Objective: To study the clinical features of InH-AAE, and to make, for the first time, independent comparisons with hereditary angioedema of unknown origin (U-HAE), as well as with hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE). Read More

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http://dx.doi.org/10.1016/j.jaip.2018.04.018DOI Listing
April 2018
3 Reads

[Acquired C1 esterase inhibitor deficiency via bradykinin-mediated angioedema: Four cases].

Ann Dermatol Venereol 2018 Oct 17;145(10):598-602. Epub 2018 Apr 17.

Dermatologie, CHRU Minjoz, 3, boulevard Alexandre-Fleming, 25030 Besançon, France.

Background: Acquired C1-esterase inhibitor (C1-INH) deficiency angioedema (C1-INH-AAE) is a form of bradykinin-mediated angioedema. This rare disorder is due to acquired consumption of C1-INH, hyperactivation of the classic pathway of human complement, and potentially fatal recurrent angioedema symptoms. Clinical symptoms of C1-INH-AAE are very similar to those of hereditary angioedema (HAE) but usually appear after the fourth decade of life and induce abdominal pain less frequently. Read More

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http://dx.doi.org/10.1016/j.annder.2018.02.012DOI Listing
October 2018
8 Reads

Atypical presentation of acquired angioedema.

Cutis 2018 02;101(2):E14-E16

Department of Dermatology, Penn State Hershey Medical Center, USA.

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February 2018
5 Reads

Refractory Abdominal Pain in a Patient with Chronic Lymphocytic Leukemia: Be Wary of Acquired Angioedema due to C1 Esterase Inhibitor Deficiency.

Case Rep Hematol 2018 10;2018:7809535. Epub 2018 Jan 10.

Department of Medicine, Reading Hospital, West Reading, PA, USA.

Acquired angioedema due to C1 inhibitor deficiency (C1INH-AAE) is a rare and potentially fatal syndrome of bradykinin-mediated angioedema characterized by episodes of angioedema without urticaria. It typically manifests with nonpitting edema of the skin and edema in the gastrointestinal (GI) tract mucosa or upper airway. Edema of the upper airway and tongue may lead to life-threatening asphyxiation. Read More

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http://dx.doi.org/10.1155/2018/7809535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818943PMC
January 2018
20 Reads

Using Bronchoscopy to Detect Acquired Tracheoesophageal Fistula in Mechanically Ventilated Patients.

Anesth Pain Med 2017 Aug 22;7(4):e57801. Epub 2017 Jul 22.

Department of Anesthesiology and Perioperative Medicine, Drexel University College of Medicine, 245 N. 15th Street, Suite 7502, MS 310, Philadelphia, PA, 19102.

Introduction: An acquired Tracheoesophageal fistula (TEF) is commonly caused by a malignancy or trauma, with pulmonary infection or aspiration being the presenting symptom. However, in the critical care setting the presentation can be subtle and may present with difficult ventilation. High endotracheal tube cuff pressures can lead to tracheal erosions and thus increasing the chances for developing a TEF. Read More

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http://dx.doi.org/10.5812/aapm.57801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797673PMC
August 2017
8 Reads

A Rare Cause of Recurrent Abdominal Pain and Diarrhea.

Gastroenterology 2018 08 2;155(2):e11-e12. Epub 2018 Feb 2.

Department of Gastroenterology and Hepatology, University of Alabama at Birmingham, Alabama.

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http://dx.doi.org/10.1053/j.gastro.2017.12.035DOI Listing
August 2018
13 Reads

Hereditary and Acquired Angioedema: Heterogeneity of Pathogenesis and Clinical Phenotypes.

Int Arch Allergy Immunol 2018 26;175(3):126-135. Epub 2018 Jan 26.

Department of Medicine, Division of Allergy and Clinical Immunology, University of Salerno, Baronissi, Italy.

Recurrent angioedema (AE) without wheals is increasingly recognized as a clinical entity and a frequent cause of admission to the emergency room. The Hereditary Angioedema Working Group (HAWK) classification allowed the scientific community to go beyond the semantic confusion that dominated this topic for decades. This classification distinguishes hereditary and acquired forms of AE, either related or unrelated to C1 inhibitor deficiency. Read More

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https://www.karger.com/Article/FullText/486312
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http://dx.doi.org/10.1159/000486312DOI Listing
May 2018
51 Reads

Intermittent C1-Inhibitor Deficiency Associated with Recessive Inheritance: Functional and Structural Insight.

Sci Rep 2018 01 17;8(1):977. Epub 2018 Jan 17.

"L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan, via GB Grassi 74, 20157, Milan, Italy.

C1-inhibitor is a serine protease inhibitor (serpin) controlling complement and contact system activation. Gene mutations result in reduced C1-inhibitor functional plasma level causing hereditary angioedema, a life-threatening disorder. Despite a stable defect, the clinical expression of hereditary angioedema is unpredictable, and the molecular mechanism underlying this variability remains undisclosed. Read More

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http://dx.doi.org/10.1038/s41598-017-16667-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772639PMC
January 2018
2 Reads

Management of pediatric 'cannot intubate, cannot oxygenate'.

Acute Med Surg 2017 10 18;4(4):462-466. Epub 2017 Aug 18.

Department of Emergency and Critical Care Medicine Japanese Red Cross Society Kyoto Daini Hospital Kyoto Japan.

Case: "Cannot intubate, cannot oxygenate" (CICO) is a rare, life-threatening situation. We describe a pediatric case of CICO and highlight some educational points.A 3-year-old boy who collapsed in the bathtub came to our emergency department. Read More

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http://dx.doi.org/10.1002/ams2.305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649306PMC
October 2017
5 Reads

Acquired Arnold-Chiari malformation in a 16-year-old patient with hereditary angioedema.

Pediatr Allergy Immunol 2017 12 24;28(8):850-852. Epub 2017 Oct 24.

Dermatology and Venereology, Medical University of Plovdiv, Plovdiv, Bulgaria.

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http://dx.doi.org/10.1111/pai.12777DOI Listing
December 2017
3 Reads

Clinical and biological response to rituximab treatment in 3 patients with acquired C1-inhibitor deficiency.

Ann Allergy Asthma Immunol 2017 Oct 31;119(4):380-382. Epub 2017 Aug 31.

Division of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, New York.

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http://dx.doi.org/10.1016/j.anai.2017.07.032DOI Listing
October 2017
4 Reads

Idiopathic non-histaminergic acquired angioedema: a case series and discussion of published clinical trials.

Clin Transl Allergy 2017 31;7:27. Epub 2017 Aug 31.

Department of Clinical Immunology, University Hospital Zurich, Gloriastrasse 23, 8091 Zurich, Switzerland.

Background: Idiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease for which there are no available laboratory parameters to clearly define the disorder. Therapy is often difficult and various treatment options have been proposed. In this paper, we have evaluated the most effective therapies for InH-AAE on the basis of current literature and report the therapeutic effect of omalizumab in three patients with InH-AAE. Read More

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http://dx.doi.org/10.1186/s13601-017-0164-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577688PMC
August 2017
17 Reads

Angioedema.

Dtsch Arztebl Int 2017 Jul;114(29-30):489-496

Department of Otorhinolaryngology, Ulm University Hospital; Department of Anaesthesiology, Ulm University Hospital.

Background: Acute angioedema of the upper airways can be life-threatening. An important distinction is drawn between mast-cell-mediated angioedema and bradykinin-mediated angioedema; the treatment of these two entities is fundamentally different.

Methods: This review is based on pertinent articles retrieved by a selective search in PubMed and on guidelines concerning the treatment of angioedema. Read More

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http://dx.doi.org/10.3238/arztebl.2017.0489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569554PMC
July 2017
30 Reads

Acquired C1 Inhibitor Deficiency.

Immunol Allergy Clin North Am 2017 08 15;37(3):497-511. Epub 2017 May 15.

Department of Medicine, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Cox 201 Allergy Associates, Boston, MA 02114, USA.

Acquired angioedema due to C1-INH deficiency (C1-INH-AAE) can occur when there are acquired (not inherited) deficiencies of C1-INH. A quantitative or functional C1-INH deficiency with negative family history and low C1q is diagnostic of C1-INH-AAE. The most common conditions associated with C1-INH-AAE are autoimmunity and B-cell lymphoproliferative disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898561173003
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http://dx.doi.org/10.1016/j.iac.2017.03.002DOI Listing
August 2017
36 Reads

Angioedema: Perioperative management.

SAGE Open Med Case Rep 2017 8;5:2050313X17713912. Epub 2017 Jun 8.

Department of Anesthesiology and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Objective: To describe the perioperative management of a patient with acquired angioedema (AAE).

Methods: A 66-year-old Caucasian male presented from an outside hospital with a history of acquired angioedema and gastrointestinal stromal tumor-related intractable urticaria and mastocytosis. He was admitted for urgent laparoscopic partial gastrectomy, secondary to gastric outlet obstruction symptomatology. Read More

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http://dx.doi.org/10.1177/2050313X17713912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467965PMC
June 2017
5 Reads

Angioedema suppressed by a combination of anti-histamine and leukotriene modifier.

Allergy Asthma Clin Immunol 2017 13;13:28. Epub 2017 Jun 13.

Division of Allergy and Clinical Immunology, Department of Medicine, St. Michael's Hospital, Toronto, Canada.

Rationale: Angioedema without co-existent urticaria is due to a limited number of causes, including hereditary and acquired C1 esterase inhibitor deficiency, drug-induced angioedema or idiopathic histaminergic or non-histaminergic angioedema. We describe a cohort of patients with recurrent angioedema whose clinical features and response to medications are distinct from the causes above.

Methods: Patients were accrued retrospectively from an academic allergy practice between 2007 and 2014. Read More

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http://dx.doi.org/10.1186/s13223-017-0201-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469062PMC
June 2017
1 Read

Angioedema in the emergency department: a practical guide to differential diagnosis and management.

Int J Emerg Med 2017 Dec 13;10(1):15. Epub 2017 Apr 13.

Department of Emergency Medicine, University Hospital, Aintree, Liverpool, UK.

Background: Angioedema is a common presentation in the emergency department (ED). Airway angioedema can be fatal; therefore, prompt diagnosis and correct treatment are vital.

Objective Of The Review: Based on the findings of two expert panels attended by international experts in angioedema and emergency medicine, this review aims to provide practical guidance on the diagnosis, differentiation, and management of histamine- and bradykinin-mediated angioedema in the ED. Read More

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http://dx.doi.org/10.1186/s12245-017-0141-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389952PMC
December 2017
9 Reads