Search our Database of Scientific Publications and Authors

I’m looking for a

    7278 results match your criteria Angioedema

    1 OF 146

    The expanding field of biologics in the management of chronic urticaria.
    J Allergy Clin Immunol Pract 2017 Jul 19. Epub 2017 Jul 19.
    University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:
    Chronic urticaria (CU) is the occurrence of urticaria with or without angioedema for at least 6 weeks. Management has traditionally involved antihistamines as first-line therapy with various alternative therapies for refractory cases. Largely based on the success of biologics for various diseases, this class of drugs has come to the forefront of medical research. Read More

    Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders.
    J Investig Allergol Clin Immunol 2017 ;27(4):213-224
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
    Primary immunodeficiency disorders (PIDs) are caused by 1 or more defects of the immune system. Patients are more likely to experience recurrent and/or severe infections and tend to develop a wide range of complications. Respiratory diseases are the main and initial manifestation in most cases and the most common complication. Read More

    Mastocytosis: from a Molecular Point of View.
    Clin Rev Allergy Immunol 2017 Jul 19. Epub 2017 Jul 19.
    Floridsdorf Allergy Center (FAZ), Vienna, Austria.
    Mast cells (MCs) are physiologically activated by binding of stem cell factor (SCF) to the extracellular domains of the Kit receptor. This binding increases the proliferation and prolongs the survival of normal mature MCs, as well as intensifies the release of mediators. In mastocytosis, somatic mutations of the coding Kit gene cause autocrine dysregulation and lead to constitutive KIT activation even in the absence of its ligand SCF. Read More

    Antihypertensive drug associated angioedema: effect modification by race/ethnicity.
    Pharmacoepidemiol Drug Saf 2017 Jul 19. Epub 2017 Jul 19.
    Centers for Medicare and Medicaid Services, Washington, DC, USA.
    Purpose: Assess angioedema risk with exposure to angiotensin converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) compared with beta-blockers, by race/ethnicity.

    Methods: New-user cohorts of Medicare beneficiaries 65 years or older initiating ACEI, ARB, or beta-blocker treatment from March 2007 to March 2014 were constructed. Angioedema incidence rates by drug and race/ethnicity were computed for 1-30 and 31-365 days of treatment. Read More

    Angioedema Spotlight: A Closer Examination of Sacubitril/Valsartan Safety Results.
    J Am Board Fam Med 2017 Jul-Aug;30(4):556-557
    From the Department of Pharmacy, Clinical and Administrative Sciences, University of Oklahoma Health Sciences Center, Oklahoma City (REO); Clinical Pharmacy Specialist, Cardiology/Anticoagulation, Methodist University Hospital, Memphis, TN (CSO); and Department of Clinical Pharmacy, University of Tennessee College of Pharmacy, Nashville (CSO).
    Incorporation of neprilysin inhibition into heart failure pharmacotherapy regimens has recently been recommended by U.S. guidelines, based on results from the PARADIGM-HF trial comparing sacubitril/valsartan to enalapril. Read More

    Incidence of Adverse Contrast Reaction Following Nonintravenous Urinary Tract Imaging.
    Eur Urol Focus 2017 Feb 5;3(1):89-93. Epub 2016 Feb 5.
    Department of Urology, Loyola University Medical Center, Maywood, IL, USA; 1:MAP Surgical Analytics Group, Loyola University Medical Center, Maywood, IL, USA; Department of Surgery, Loyola University Medical Center, Maywood, IL, USA.
    Adverse reactions (ARs) to intravenous (IV) radiographic contrast range from mild urticaria to life-threatening anaphylaxis. Intraluminal contrast dye is routinely used in the urinary tract with a minimal perceived risk of AR. We used the Healthcare Cost and Utilization Project State Inpatient Databases for California and Florida from 2007 to 2011 to identify patients who received urinary tract contrast dye for retrograde pyelography, percutaneous pyelography, retrograde/other cystogram, and ileal conduitogram. Read More

    The Complex Interaction Between Polycystic Ovary Syndrome and Hereditary Angioedema: Case Reports and Review of the Literature.
    Obstet Gynecol Surv 2017 Jul;72(7):417-424
    Gynecologist/Obstetrician, Disciplina de Ginecologia; Associate Professor, Disciplina de Ginecologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
    Importance: Hereditary angioedema (HAE) is a rare but severe disease, with high risk of death, and attacks have been associated to high estrogen levels. Polycystic ovary syndrome (PCOS) is a common hyperandrogenic condition, which is frequently treated with combined oral contraceptives.

    Objective: The aim of this study was to describe 2 clinical cases of young women diagnosed as having PCOS who developed HAE attacks after the introduction of combined estrogen-progestin pills to treat PCOS symptoms. Read More

    The relationship between anxiety and quality of life in children with hereditary angioedema.
    Pediatr Allergy Immunol 2017 Jul 10. Epub 2017 Jul 10.
    University of Haifa Occupational Therapy Department Faculty of Social Welfare and Health Sciences, Haifa, Israel.
    Background: The severe life-threatening characteristics of hereditary angioedema (HAE) with C1-inhibitor deficiency (C1-INH-HAE) can affect anxiety levels among pediatric patients. This emotional burden together with the physical restrictions of C1-INH-HAE may decrease children's health-related quality of life (HRQoL).

    Objective: (1) To compare anxiety state and trait between children with C1-INH-HAE and healthy controls (2) To examine the relationship between the level of anxiety of children with C1-INH-HAE, their disease activity/affected sites and their HRQoL (3) To predict the HRQoL of children with C1-INH-HAE based on their anxiety level and disease activity/affected sites. Read More

    Breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis are responsive to icatibant: findings from the Icatibant Outcome Survey.
    Allergy Asthma Clin Immunol 2017 5;13:31. Epub 2017 Jul 5.
    Shire, Zählerweg 10, 6300 Zug, Switzerland.
    Background: Patients with hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE) experience recurrent attacks of cutaneous or submucosal edema that may be frequent and severe; prophylactic treatments can be prescribed to prevent attacks. However, despite the use of long-term prophylaxis (LTP), breakthrough attacks are known to occur. We used data from the Icatibant Outcome Survey (IOS) to evaluate the characteristics of breakthrough attacks and the effectiveness of icatibant as a treatment option. Read More

    Pharmacoeconomics of Orphan Disease Treatment with a Focus on Hereditary Angioedema.
    Immunol Allergy Clin North Am 2017 Aug 13;37(3):617-628. Epub 2017 May 13.
    Internal Medicine/Allergy/Immunology Division, University of Texas Southwestern Medical School, Dallas, TX, USA; AARA Research Associates, Private Practice, 10100 North Central Expressway, Suite 100, Dallas, TX 75231, USA. Electronic address:
    This article discusses orphan diseases, their prevalence, legislative incentives to encourage development of therapies, and the impact of treatment on health care payment systems. Specifically, the cost burden of hereditary angioedema on patients, health care systems, and society is reviewed. The impact of availability of and access to novel and specific therapies on morbidity, mortality, and overall burden of disease is explored. Read More

    Burden of Illness and Quality-of-Life Measures in Angioedema Conditions.
    Immunol Allergy Clin North Am 2017 Aug;37(3):597-616
    Allergy Department, Hospital Universitario Severo Ochoa, Avenida de Orellana s/n, Leganés, Madrid 28911, Spain.
    Burden of illness studies and evaluation of health-related quality of life using validated questionnaires have become an important task in the comprehensive management of angioedema conditions, mainly angioedema associated with chronic spontaneous urticaria and hereditary angioedema caused by C1-inhibitor deficiency. A review of the principal tools and studies is presented. Both diseases present a higher proportion of psychiatric disorders, impair work and studies productivity, and produce high direct and indirect costs. Read More

    Emerging Therapies in Hereditary Angioedema.
    Immunol Allergy Clin North Am 2017 Aug;37(3):585-595
    Division of Rheumatology, Department of Medicine, Allergy & Immunology, University of California San Diego, 8899 University City Lane, Suite 230, San Diego, CA 92122, USA.
    Remarkable progress has been made in the treatment of bradykinin-mediated angioedema with the advent of multiple new therapies. Patients now have effective medications available for prophylaxis and treatment of acute attacks. However, hereditary angioedema is a burdensome disease that can lead to debilitating and dangerous angioedema episodes associated with significant costs for individuals and society. Read More

    Hereditary Angioedema with Normal C1 Inhibitor: Update on Evaluation and Treatment.
    Immunol Allergy Clin North Am 2017 Aug;37(3):571-584
    Department of Dermatology and Allergy, Allergie-Centrum-Charité/ECARF, Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany.
    A new form of hereditary angioedema (HAE) was identified in the year 2000. Its clinical appearance resembles HAE types I and II, which are caused by mutations that result in a deficiency of C1 inhibitor (C1-INH). In patients with the new form of HAE, C1-INH plasma levels and function values are normal, so it's termed HAE with normal C1-INH (HAE-nC1). Read More

    Prophylactic Therapy for Hereditary Angioedema.
    Immunol Allergy Clin North Am 2017 Aug;37(3):557-570
    Department of Immunology, Barts Health NHS Trust, Pathology and Pharmacy Building, 80 Newark Street, London E1 2HS, UK.
    Long-term prophylaxis is needed in many patients with hereditary angioedema and poses many challenges. Attenuated androgens are effective in many but are limited by side effect profiles. There is less evidence for efficacy of tranexamic acid and progestagens; however, the small side effect profile makes tranexamic acid an option for prophylaxis in children and progestagens an option for women. Read More

    Acute Management of Hereditary Angioedema Attacks.
    Immunol Allergy Clin North Am 2017 Aug 23;37(3):541-556. Epub 2017 May 23.
    Immunology and Allergy Unit, Department of Medicine, Campbelltown Hospital, Therry Road, Campbelltown, Sydney, New South Wales 2560, Australia. Electronic address:
    Several treatment modalities have become available for management of acute hereditary angioedema (HAE) attacks in the last 15 years. Most are now available to patients in North America, Europe, United Kingdom, and Australia, but few options exist in developing countries. Preferred contemporary use of the treatments to be discussed is "on demand," because control remains with the patient and delays in treatment access avoided. Read More

    Laboratory Approaches for Assessing Contact System Activation.
    Immunol Allergy Clin North Am 2017 Aug;37(3):527-539
    Department of Medicine, University of California, 9500 Gilman Drive, Mailcode 0732, La Jolla, CA 92093, USA; San Diego Veterans Administration Healthcare System, Medicine Service, 3350 La Jolla Village Drive, San Diego, CA 92161, USA. Electronic address:
    Hereditary angioedema (HAE) is a rare autosomal dominant disease clinically characterized by recurrent, often unpredictable attacks of subcutaneous and mucosal swelling. Acute episodes are debilitating, painful, disfiguring, and potentially fatal. HAE type I and type II result from a deficiency in the plasma level of functional C1 inhibitor. Read More

    Pathogenesis of Hereditary Angioedema: The Role of the Bradykinin-Forming Cascade.
    Immunol Allergy Clin North Am 2017 Aug;37(3):513-525
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.
    Hereditary angioedema (HAE) is an autosomal-dominant disorder owing to mutations in the C1 inhibitor gene. Type I is characterized by a low C1 inhibitor protein level and diminished functional activity, whereas type II has a normal (or elevated) protein level but diminished function. When functional levels drop beyond 40% of normal, attacks of swelling are likely to occur due to overproduction of bradykinin. Read More

    Acquired C1 Inhibitor Deficiency.
    Immunol Allergy Clin North Am 2017 Aug 15;37(3):497-511. Epub 2017 May 15.
    Department of Medicine, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Cox 201 Allergy Associates, Boston, MA 02114, USA.
    Acquired angioedema due to C1-INH deficiency (C1-INH-AAE) can occur when there are acquired (not inherited) deficiencies of C1-INH. A quantitative or functional C1-INH deficiency with negative family history and low C1q is diagnostic of C1-INH-AAE. The most common conditions associated with C1-INH-AAE are autoimmunity and B-cell lymphoproliferative disorders. Read More

    Angiotensin-converting Enzyme Inhibitor and Other Drug-associated Angioedema.
    Immunol Allergy Clin North Am 2017 Aug;37(3):483-495
    Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South D-3100, Medical Center North, Nashville, TN 37232, USA. Electronic address:
    Nonsteroidal antiinflammatory agents, β-lactam antibiotics, non-β lactam antibiotics, and angiotensin-converting enzyme inhibitors are the most common classes of drugs that cause angioedema. Drug-induced angioedema is known to occur via mechanisms mediated by histamine, bradykinin, or leukotriene, and an understanding of these mechanisms is crucial in guiding therapeutic decisions. Nonallergic angioedema occurs in patients with genetic variants that affect metabolism or synthesis of bradykinin, substance P, prostaglandins, or leukotrienes, or when patients are taking drugs that have synergistic mechanisms. Read More

    Histaminergic Angioedema.
    Immunol Allergy Clin North Am 2017 Aug 13;37(3):467-481. Epub 2017 May 13.
    Division of Allergy and Clinical Immunology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029-6574, USA.
    Angioedema is frequently categorized into histamine- or bradykinin-mediated disease. It is critical to determine the underlying mediator of symptoms as it directs treatment. Histaminergic angioedema is the most frequent cause of angioedema. Read More

    The Clinical Evaluation of Angioedema.
    Immunol Allergy Clin North Am 2017 Aug;37(3):449-466
    Division of Clinical Immunology and Allergy, St. Michael's Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada. Electronic address:
    The clinical evaluation of angioedema is reliant on obtaining a thorough patient and family history with an assessment of risk factors and presenting symptoms unique to each subtype. It is important to distinguish between angioedema with and without urticaria as a primary step in the evaluation; thereafter, laboratory parameters and investigations allow for subsequent stratification. There is a significant disease burden associated with angioedema and thus it is essential for health care practitioners to establish a prompt and accurate diagnosis, and a comprehensive care plan that addresses the patient's physical and mental well-being alike. Read More

    Management of persistent lingual angioedema: a team approach.
    Gen Dent 2017 Jul-Aug;65(4):60-62
    A 70-year-old African American man suffered anoxic encephalopathy following a choking episode. He had a history of hypertension, which was being treated with lisinopril, an angiotensin-converting enzyme inhibitor (ACEI). Soon after the patient's admission to an intensive care unit, his tongue began to swell until it reached more than twice its normal size and extended almost 2 inches outside his mouth. Read More

    Risk of angioedema associated with levetiracetam compared with phenytoin: Findings of the observational health data sciences and informatics research network.
    Epilepsia 2017 Jul 6. Epub 2017 Jul 6.
    Observational Health Data Sciences and Informatics (OHDSI) Collaborative.
    Recent adverse event reports have raised the question of increased angioedema risk associated with exposure to levetiracetam. To help address this question, the Observational Health Data Sciences and Informatics research network conducted a retrospective observational new-user cohort study of seizure patients exposed to levetiracetam (n = 276,665) across 10 databases. With phenytoin users (n = 74,682) as a comparator group, propensity score-matching was conducted and hazard ratios computed for angioedema events by per-protocol and intent-to-treat analyses. Read More

    Cold-induced anaphylaxis: the case of a 9-year-old child and review of the literature.
    Endocr Metab Immune Disord Drug Targets 2017 Jul 3. Epub 2017 Jul 3.
    University of Bari - Department of Biomedical Science and Human Oncology, Dermatological Clinic Bari. Italy.
    Background And Objective: The present review investigated cold-induced anaphylaxis, a potentially life-threatening condition that occurs after exposure to cold stimuli and is characterized by respiratory distress and/or hypotension. Anaphylaxis is rarely associated to cold-induced urticarial (CU), a particular form of physical urticaria that is difficult to diagnose and manage. The incidence of cold-induced urticaria has been estimated at about 0. Read More

    Patient satisfaction and experience with intravenously administered C1-inhibitor concentrates in the United States.
    Ann Allergy Asthma Immunol 2017 Jul;119(1):59-64
    CSL Behring, King of Prussia, Pennsylvania.
    Background: Hereditary angioedema (HAE) is a rare genetic disorder with substantial morbidity and mortality. Despite expanded choices for effective acute treatment, prophylactic options are more limited. Intravenous C1 esterase inhibitor (C1-INH[IV]) is licensed and used to prevent HAE symptoms. Read More

    Preventing Hereditary Angioedema Attacks in Children Using Cinryze®: Interim Efficacy and Safety Phase 3 Findings.
    Int Arch Allergy Immunol 2017 Jun 30;173(2):114-119. Epub 2017 Jun 30.
    Department for Children and Adolescents, Angioedema Centre, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
    Background: Hereditary angioedema (HAE) is a rare genetic disease causing unpredictable and potentially life-threatening subcutaneous and submucosal edematous attacks. Cinryze® (Shire ViroPharma Inc., Lexington, MA, USA), a nanofiltered C1 inhibitor (C1-INH), is approved in Europe for the treatment, preprocedure prevention, and routine prophylaxis of HAE attacks, and for the routine prophylaxis of attacks in the USA. Read More

    Harefuah 2017 Jun(1):385-389
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center (affiliated to the Technion Medicine Faculty).
    Introduction: Chronic urticaria is a disease manifested by a pruritic rash lasting longer than 6 weeks that may severely affect quality of life and daily function. Chronic urticaria can be further divided into chronic spontaneous urticaria which appears without a trigger and chronic inducible urticaria which evolves following distinct physical triggers. These two clinical manifestations could coexist in the same patient. Read More

    [Angioedema as initial manifestation of hypogammaglobulinemia].
    Rev Alerg Mex 2017 Apr-Jun;64(2):228-234
    Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica, Ciudad de México, México.
    Common variable immunodeficiency is characterized by hypogammaglobulinemia and the inability to respond to vaccines. Patients mostly manifest infections, however only less than 5 % have pathological conditions as autoimmunity, granulomatous inflammation, and splenomegaly or lymphoproliferative disease among others, without showing infections. We report the case of a woman who debuted with localized cutaneous affection, facial angioedema, without other early symptoms. Read More

    Pharmacokinetic, pharmacodynamic, and antihypertensive effects of the neprilysin inhibitor LCZ-696: sacubitril/valsartan.
    J Am Soc Hypertens 2017 May 25. Epub 2017 May 25.
    Department of Cardiology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA. Electronic address:
    LCZ-696, sacubitril/valsartan, is a dual-acting molecule consisting of the angiotensin II (Ang II) receptor blocker valsartan and the neprilysin (neutral endopeptidase) inhibitor AHU-377 with significant beneficial effects in patients with hypertension and heart failure (HF). Several recent studies have demonstrated a higher effectiveness of LCZ-696 compared to valsartan in the treatment of hypertension and HF. The rationale for the development and the Food and Drug Administration approval of LCZ-696 was based on the concept of an additive effect of the Ang II receptor blocker valsartan and the neutral endopeptidase (neprilysin) inhibitor AHU-377 for the treatment of hypertension and HF. Read More

    [Allergy to drugs. Experience in 771 procedures].
    Medicina (B Aires) 2017 ;77(3):180-184
    Unidad de Alergia, Asma e Inmunología Clínica, Buenos Aires, Argentina.
    Drug hypersensitivity reactions (RHD) are those that present clinically as allergic. They can or cannot involve an immunologic mechanism of lesion. They are frequent and, occasionally, life threatening. Read More

    Review of Physical Urticarias and Testing Methods.
    Curr Allergy Asthma Rep 2017 Aug;17(8):51
    Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela.
    Purpose Of Review: This review aims to update the information available on the prevalence, clinical picture, diagnostic methods, and treatment of urticarias induced by external physical stimuli.

    Recent Findings: Physical urticarias are present in up to 5% of the general population, and in 10 to 50% of patients with chronic urticaria. Recent investigations have provided evidence that the presence of physical urticaria alone or when comorbid with chronic spontaneous urticaria is associated with a worse prognosis and duration. Read More

    Angioedema: Perioperative management.
    SAGE Open Med Case Rep 2017 8;5:2050313X17713912. Epub 2017 Jun 8.
    Department of Anesthesiology and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Objective: To describe the perioperative management of a patient with acquired angioedema (AAE).

    Methods: A 66-year-old Caucasian male presented from an outside hospital with a history of acquired angioedema and gastrointestinal stromal tumor-related intractable urticaria and mastocytosis. He was admitted for urgent laparoscopic partial gastrectomy, secondary to gastric outlet obstruction symptomatology. Read More

    Autoimmune progesterone dermatitis presenting as fixed drug eruption: a case report.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    Autoimmune progesterone dermatitis (APD) is a rare disorder characterized by periodic skin lesions that erupt during the luteal phase of the menstrual cycle. Clinical manifestations of APD is caused by an unusual allergy to progesterone and has a wide range of clinical manifestations from eczema and urticaria to angioedema and erythema multiforme. A 46-year-old woman described recurrent, round erythematous plaques on the lower lip, both forearms and buttocks. Read More

    [Case report. Pulmonary embolism complicated by angioneurotic edema.]
    Rev Med Liege 2017 Jun;72(6):275-280
    GIGA Cardiovascular Sciences, Heart Valve Clinic. Université de Liège.
    Although angioneurotic oedema (AE) is a rare entity, it sometimes leads to devastating consequences. We report the case of an oro-pharyngeal angioneurotic attack following the initiation of a fibrinolysis therapy by alteplase and relay by heparin in a patient with severe acute pulmonary embolism. In view of this original case, we propose to highlight the most recent elements concerning the physiopathology of this disease. Read More

    Angioedema suppressed by a combination of anti-histamine and leukotriene modifier.
    Allergy Asthma Clin Immunol 2017 13;13:28. Epub 2017 Jun 13.
    Division of Allergy and Clinical Immunology, Department of Medicine, St. Michael's Hospital, Toronto, Canada.
    Rationale: Angioedema without co-existent urticaria is due to a limited number of causes, including hereditary and acquired C1 esterase inhibitor deficiency, drug-induced angioedema or idiopathic histaminergic or non-histaminergic angioedema. We describe a cohort of patients with recurrent angioedema whose clinical features and response to medications are distinct from the causes above.

    Methods: Patients were accrued retrospectively from an academic allergy practice between 2007 and 2014. Read More

    Safety of the neprilysin/renin-angiotensin system inhibitor LCZ696.
    Oncotarget 2017 May 31. Epub 2017 May 31.
    Department of Cardiology, Qilu Hospital of Shandong University, Ji'nan, 250012, PR China.
    Objectives: The combined neprilysin/rennin-angiotensin system inhibitor sacubitril/valsartan (LCZ696) has shown its superiority over ACEI/ARB therapy. In view of the existing concern of its adverse effects, we aimed to provide evidence of the safety of the new drug.

    Results: A total of 6 randomized trials with 11,821 subjects were included in this analysis. Read More

    Pretreatment with different doses of dexamethasone in the prevention of docetaxel-induced hypersensitivity.
    Pak J Pharm Sci 2017 Jan;30(1):61-65
    Department of Oncology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
    This study aimed to evaluate the efficacy and safety of dexamethasone pretreatment regimen with different doses in the prevention of docetaxel-induced hypersensitivity reaction (HSR). One hundred and sixty-two patients who had malignant tumors as determined by histology and/or cytology and received docetaxel treatments at least 2 cycles, were randomized into two groups. There were 90 patients in the study group and 72 patients in the control group. Read More

    Mutation of the angiopoietin-1 gene (ANGPT1) associates with a new type of hereditary angioedema.
    J Allergy Clin Immunol 2017 Jun 8. Epub 2017 Jun 8.
    Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. Electronic address:
    Background: Hereditary angioedema (HAE) is a rare genetic disease usually caused by mutation in the C1 inhibitor or the coagulation Factor XII gene. However, in a series of patients with HAE, no causative variants have been described, and the pathophysiology of the disease remains unknown (hereditary angioedema with yet unknown genetic defect [U-HAE]). Identification of causative genes in patients with U-HAE is valuable for understanding the cause of the disease. Read More

    Treatment Effect and Safety of Icatibant in Pediatric Patients with Hereditary Angioedema.
    J Allergy Clin Immunol Pract 2017 Jun 7. Epub 2017 Jun 7.
    Institute for Asthma and Allergy, Chevy Chase, Md.
    Background: Clinical manifestations of hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) usually begin in childhood, often intensifying during puberty. Currently there are insufficient efficacy/safety data for HAE therapies in children and adolescents due to the small number of pediatric patients enrolled in studies.

    Objective: The objective of this phase 3 study was to evaluate the efficacy/safety of a single subcutaneous dose of icatibant (0. Read More

    The role of the complement system in hereditary angioedema.
    Mol Immunol 2017 Jun 5. Epub 2017 Jun 5.
    3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
    Hereditary angioedema (HAE) is a rare, but potentially life-threatening disorder, characterized by acute, recurring, and self-limiting edematous episodes of the face, extremities, trunk, genitals, upper airways, or the gastrointestinal tract. HAE may be caused by the deficiency of C1-inhibitor (C1-INH-HAE) but another type of the disease, hereditary angioedema with normal C1-INH function (nC1-INH-HAE) was also described. The patient population is quite heterogeneous as regards the location, frequency, and severity of edematous attacks, presenting large intra- and inter-individual variation. Read More

    Atypical Lichen Myxedematosus: A Case with Remarkable Response to Low Dose Melphalan.
    Indian Dermatol Online J 2017 May-Jun;8(3):198-200
    Department of Dermatology and Venereology, Government Medical College, Alappuzha, Kerala, India.
    A 41-year-old man was referred to our outpatient department with a diagnosis of urticaria with angioedema of 3 months duration. On examination, he had generalized coalescent waxy papules and diffuse periorbital swelling. Systemic examination was unremarkable except for limited finger flexion. Read More

    Increased serum soluble vascular endothelial cadherin levels in patients with chronic spontaneous urticaria.
    Ann Allergy Asthma Immunol 2017 Jun;118(6):704-709
    Department of Dermato-Venereology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
    Background: Chronic spontaneous urticaria (CSU) is a common skin disease characterized by recurrent itchy wheals with or without angioedema that lasts longer than 6 weeks. Vascular endothelial (VE)-cadherin is an endothelial cell-specific adhesion molecule that plays critical roles in angiogenesis and endothelial permeability.

    Objective: To investigate serum levels of soluble VE (sVE)-cadherin in patients with CSU. Read More

    1 OF 146