7,942 results match your criteria Angioedema


Endothelial B2-receptor overexpression as an alternative animal model for hereditary angioedema.

Allergy 2019 Apr 20. Epub 2019 Apr 20.

Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Strasse 10, 13125, Berlin, Germany.

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http://dx.doi.org/10.1111/all.13836DOI Listing

Anaphylaxis after wheat ingestion in a patient with coeliac disease: two kinds of reactions and the same culprit food.

Eur J Gastroenterol Hepatol 2019 Apr 15. Epub 2019 Apr 15.

Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, Rome, Italy.

In recent years, the role of atopic dermatitis epidermal skin barrier defects in inducing a transcutaneous allergic sensitization is highly debated, possibly explaining why some children with eczema are sensitized to foods they have never eaten. In our specific situation, the association between coeliac disease and wheat allergy might be particularly harmful owing to unavoidable strict food avoidance. We describe the case of a young boy affected by coeliac disease who, after an occasional unexpected ingestion of gluten, experienced a complete anaphylactic reaction characterized by urticarial, labial angioedema, wheezing, and hypotension. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001421DOI Listing
April 2019
2 Reads

Recombinant Human C1 Esterase Inhibitor Treatment for Hereditary Angioedema Attacks in Children.

Pediatr Allergy Immunol 2019 Apr 16. Epub 2019 Apr 16.

Charité Universitätsmedizin Berlin, Berlin, Germany.

Background: Attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency (C1-INH-HAE) usually begin during childhood or adolescence. However, limited data are available regarding indications and modalities of treatment of children. This study evaluated recombinant human C1-INH (rhC1-INH) for HAE attacks in children. Read More

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http://dx.doi.org/10.1111/pai.13065DOI Listing
April 2019
1 Read

An Observational Study to Describe the Clinical Pattern of Dermatological Emergencies from Emergency Department and Intensive Care Unit: Our Experience from a Tertiary Care Hospital in Northern India.

Indian Dermatol Online J 2019 Mar-Apr;10(2):144-148

Department of Dermatology, MLN Medical College, Allahabad, Uttar Pradesh, India.

Background: A large number of skin diseases have the potential to culminate into potentially fatal "acute skin failure." The concept of dermatological intensive care unit (ICU) has largely evolved as a result of increased number of emergencies encountered by dermatologists these days. Dermatological emergencies comprise 8-20% of cases presenting to the emergency department. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_318_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434742PMC
April 2019
2 Reads

Autoimmune Theories of Chronic Spontaneous Urticaria.

Front Immunol 2019 29;10:627. Epub 2019 Mar 29.

Department of Immunology, Duke University Medical Center, Durham, NC, United States.

Urticaria (hives) is a highly prevalent skin disorder that can occur with or without associated angioedema. Chronic spontaneous urticaria (CSU) is a condition which persists for more than 6 weeks in duration and occurs in the absence of an identifiable provoking factor. CSU results from pathogenic activation of mast cells and basophils, which gives rise to the release of proinflammatory mediators that support the generation of urticaria. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450064PMC
March 2019
2 Reads

A Randomized Trial of human C1 inhibitor prophylaxis in children with hereditary angioedema.

Pediatr Allergy Immunol 2019 Apr 9. Epub 2019 Apr 9.

HRZM Hemophilie Center Rhein Main, Mörfelden-Walldorf, Germany.

Background: Patients with hereditary angioedema with C1 inhibitor deficiency or dysfunction have burdensome recurrent angioedema attacks. The safety, efficacy, and health-related quality of life (HRQoL) outcomes of C1 inhibitor (C1-INH) prophylaxis (intravenously administered) in patients aged 6-11 years were investigated.

Methods: Eligible patients were enrolled in a randomized, single-blind, crossover phase 3 trial. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pai.13060
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http://dx.doi.org/10.1111/pai.13060DOI Listing
April 2019
5 Reads

Albumin plasma exchange for life-threatening angioedema with normal C1-inhibitor.

J Allergy Clin Immunol Pract 2019 Apr 26;7(4):1360-1361. Epub 2018 Oct 26.

Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; University College London Hospitals NHS Foundation Trust, Department of Medicine, London, United Kingdom; Cardiometabolic Programme-NIHR UCLH/UCL BRC, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaip.2018.10.022DOI Listing
April 2019
1 Read

Angioedema-induced by nonsteroidal anti-inflammatory drugs: a genotype-phenotype correlation in a Brazilian population.

J Investig Allergol Clin Immunol 2019 Apr 8. Epub 2019 Apr 8.

Center for Research and Diagnostic of Genetic Diseases - Department of Biophysics, Universidade Federal de São Paulo, Rua Pedro de Toledo 669, 04039032, São Paulo, SP, Brazil.

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http://dx.doi.org/10.18176/jiaci.0382DOI Listing
April 2019
1 Read

Macroglossia secondary to lisinopril-induced acute angioedema.

Proc (Bayl Univ Med Cent) 2019 Jan 16;32(1):70-72. Epub 2019 Jan 16.

Department of Oral and Maxillofacial Surgery, Baylor University Medical Center at DallasDallasTexas.

Presented here are two cases of acute acquired macroglossia in adults caused by angioedema resulting from a reaction to angiotensin-converting enzyme inhibitors (ACEIs). Angioedema can be caused by a variety of factors, but ACEIs are the most common precipitating factor. Symptoms such as swelling of the lips, face, tongue, and throat can lead to life-threatening airway compromise. Read More

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https://www.tandfonline.com/doi/full/10.1080/08998280.2018.1
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http://dx.doi.org/10.1080/08998280.2018.1540736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442892PMC
January 2019
3 Reads

Novel MASP-2 inhibitors developed directed evolution of human TFPI1 are potent lectin pathway inhibitors.

J Biol Chem 2019 Apr 5. Epub 2019 Apr 5.

Department of Biochemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/C, Hungary.

The lectin pathway (LP) of the complement system is an important anti-microbial defense mechanism, but it also contributes significantly to ischemia reperfusion injury (IRI) associated with myocardial infarct, stroke and several other clinical conditions. Mannan-binding lectin (MBL)-associated serine proteinase 2 (MASP-2) is essential for LP activation and therefore it is a potential drug target. We have previously developed the first two generations of MASP-2 inhibitors by in vitro evolution of two unrelated canonical serine proteinase inhibitors. Read More

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http://dx.doi.org/10.1074/jbc.RA119.008315DOI Listing
April 2019
1 Read

The incidence of lidocaine allergy in dentists: an evaluation of 100 general dental practitioners.

Int J Occup Med Environ Health 2019 Apr 2. Epub 2019 Apr 2.

Medical University of Lodz, Łódź, Poland (Department of Oral Surgery).

Objectives: Local anesthetics are some of the most common drugs used in dentistry and about 6 million people daily around the world are subjected to their effect in procedures performed by a similar number of dentists who, in turn, are usually not aware of the fact of being allergic to this group of medications. Assuming that dentists are also patients, and that in their daily practice the contact with the allergen is very frequent, it is essential to assess the incidence of allergy to lidocaine in general dental practitioners.

Material And Methods: The authors evaluated a group of 100 general dental practitioners in whom adverse reactions similar to anaphylaxis occurred after local anesthesia. Read More

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http://www.journalssystem.com/ijomeh/Incidence-of-lidocaine-
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http://dx.doi.org/10.13075/ijomeh.1896.01235DOI Listing
April 2019
3 Reads

Small bowel angioedema due to intravenous administration of gadobenate dimeglumine.

Diagn Interv Imaging 2019 Mar 29. Epub 2019 Mar 29.

Department of Radiology, Hôpital Jean Verdier, Hôpitaux Universitaires Paris-Seine-Saint-Denis, AP-HP, 93140, Bondy, France; Unité de Formation et de recherche SMBH, université Paris 13, Communauté d'Universités et Etablissements Sorbonne-Paris Cité, 93000 Bobigny, France. Electronic address:

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http://dx.doi.org/10.1016/j.diii.2019.03.006DOI Listing
March 2019
1 Read

Life-Threatening Angioedema Following Varenicline Administration.

J Clin Psychopharmacol 2019 May/Jun;39(3):285-287

Department of Emergency Medicine, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan and College of Medicine, Chang Gung University, Taoyuan, Taiwan School of Medicine, International Medical University, Kuala Lumpur, Malaysia and Sarawak General Hospital, Kuching, Sarawak, Malaysia Sarawak General Hospital, Kuching, Sarawak, Malaysia Department of Emergency Medicine, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan and College of Medicine, Chang Gung University, Taoyuan, Taiwan

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http://dx.doi.org/10.1097/JCP.0000000000001036DOI Listing
March 2019
2 Reads

The impact of hereditary angioedema on quality of life and family planning decisions.

Int J Psychiatry Med 2019 Mar 29:91217419837068. Epub 2019 Mar 29.

1 Department of Psychiatry, Ege University Faculty of Medicine, Izmir, Turkey.

Objective: Hereditary angioedema is a serious disease with unpredictable attacks. It has an impact on patients' health-related quality of life. This study aimed to assess the quality of life of the hereditary angioedema patients and to investigate the relationship between quality of life and demographic, clinical, laboratory, and psychiatric parameters. Read More

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http://dx.doi.org/10.1177/0091217419837068DOI Listing
March 2019
1 Read

Chronic Urticaria: An Overview of Treatment and Recent Patents.

Recent Pat Inflamm Allergy Drug Discov 2019 Mar 28. Epub 2019 Mar 28.

The Institute of Integrative Medicine, The Chinese University of Hong Kong, Shatin. Hong Kong.

Background: Up to 1% of the general population in the USA and Europe have chronic urticaria (CU) at some point in their lifetime. CU has an adverse effect on quality of life.

Objective: To provide an update on the epidemiology, pathogenesis, clinical manifestations, diagnosis, aggravating factors, complications, treatment and prognosis of CU. Read More

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http://dx.doi.org/10.2174/1872213X13666190328164931DOI Listing
March 2019
1 Read

Identification and Mapping of a 2,009-bp DNA Deletion in of a Hereditary Angioedema Patient.

Case Rep Genet 2019 24;2019:7052062. Epub 2019 Feb 24.

Division of Clinical Immunology, Department of Pathology, Queen Mary Hospital, Hong Kong.

We report a heterozygous, 2,009 base pairs (bps) genomic DNA deletion within the gene that has not previously been reported in a case of type I hereditary angioedema (HAE). The patient is a 28-year-old Han Chinese female living in Hong Kong who has suffered from recurrent angioedema since adolescence, with increasing attack frequency as she entered adulthood; in the past, episodes occurred annually, but now occur every two to three months. The affected areas are not itchy and include common sites such as the left and right forearms, but without throat involvement. Read More

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https://www.hindawi.com/journals/crig/2019/7052062/
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http://dx.doi.org/10.1155/2019/7052062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409050PMC
February 2019
3 Reads

New monoclonal/bi-specific antibodies: Reshaping transfusion medicine beyond replacement.

Transfus Apher Sci 2019 Mar 14. Epub 2019 Mar 14.

Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan. Electronic address:

Since the first successful transfusion in 1818, Transfusion Medicine has evolved significantly. The advent of plasma fractionation and availability of recombinant products allowed for precision replacement therapy to treat many hematological conditions, such as hemophilia, thrombotic thrombocytopenic purpura, and hereditary angioedema. A deeper understanding of the pathophysiology underlying those conditions along with the development of safer monoclonal and bispecific antibodies is now offering safe and effective alternatives to the simple conventional approach of replacing a missing plasma protein. Read More

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http://dx.doi.org/10.1016/j.transci.2019.03.011DOI Listing
March 2019
2 Reads

Hereditary Angioedema Type 1 with Recurrent Dizziness.

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Neurology, Nagoya University Graduate School of Medicine, Japan.

A 41-year-old woman presented with recurrent dizziness. After an attack of dizziness, she felt edematous sensations in her hands. However, according to photographs taken during the attack, the edema on the back of the patient' s hands and fingers appeared mild. Read More

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http://dx.doi.org/10.2169/internalmedicine.2015-18DOI Listing
March 2019
4 Reads

Molecular mechanisms and pathophysiology of perioperative hypersensitivity and anaphylaxis: a narrative review.

Br J Anaesth 2019 Mar 7. Epub 2019 Mar 7.

Anaesthetic Allergy Referral Centre of Western Australia, Department of Anaesthesia, Sir Charles Gairdner Hospital, Perth, Australia; Department of Pharmacology, University of Western Australia, Perth, Australia.

Perioperative hypersensitivity reactions (POH) constitute a clinical and diagnostic challenge, a consequence of heterogeneous clinical presentations, and multiple underlying pathomechanisms. POH do not necessarily involve an allergen-specific immune response with cross-linking of specific immunoglobulin E (sIgE) antibodies on mast cells and basophils. POH can also result from alternative specific and non-specific effector cell activation/degranulation such as complement-derived anaphylatoxins and off-target occupancy of mast cell, basophil, or both surface receptors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912193007
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http://dx.doi.org/10.1016/j.bja.2019.01.031DOI Listing
March 2019
5 Reads

Anaesthetic management of patients with pre-existing allergic conditions: a narrative review.

Br J Anaesth 2019 Mar 12. Epub 2019 Mar 12.

Department of Anaesthesia and Peri-operative Medicine, Auckland City Hospital, Auckland, New Zealand.

This narrative review seeks to distinguish the clinical patterns of pre-existing allergic conditions from other confounding non-allergic clinical entities, and to identify the potential related risks and facilitate their perioperative management. Follow-up investigation should be performed after a perioperative immediate hypersensitivity to establish a diagnosis and provide advice for subsequent anaesthetics, the main risk factor for perioperative immunoglobulin E (IgE)-mediated anaphylaxis being a previous uninvestigated perioperative immediate hypersensitivity reaction. The concept of cross-reactivity between drugs used in the perioperative setting and food is often quoted, but usually not supported by evidence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912193006
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http://dx.doi.org/10.1016/j.bja.2019.01.020DOI Listing
March 2019
7 Reads

Current and emerging biologics for the treatment of hereditary angioedema.

Expert Opin Biol Ther 2019 Mar 26:1-10. Epub 2019 Mar 26.

b Department of Biomedical and Clinical Sciences Luigi Sacco , University of Milan , Milan , Italy.

Introduction: Hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) is a rare disease with unpredictable, self-limiting and localized swelling episodes involving the cutaneous and subcutaneous tissues. In the last decade, the spectrum of the possibilities to control the disease has considerably changed with the development of biologic therapies making necessary a careful evaluation of the differences among current and emerging treatments to properly optimize the management of patients. Areas covered: This review serves to summarize the literature regarding the use of biologics for the treatment of C1-INH-HAE. Read More

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http://dx.doi.org/10.1080/14712598.2019.1595581DOI Listing
March 2019
1 Read

Spontaneous cutaneous adverse drug reaction reports-An analysis of a 10-year dataset in Singapore.

Pharmacol Res Perspect 2019 04 13;7(2):e00469. Epub 2019 Mar 13.

Department of Pharmacy Faculty of Science National University of Singapore Singapore Singapore.

We analyzed the spontaneous adverse event database in Singapore to determine the types of cutaneous adverse drug reactions (CADRs) and causative drugs reported. We selected 10 CADRs-of-interest, and identified the suspected drugs and the characteristics of the at-risk population. ADR reports received from 2006 to 2015 of the system organ class "Skin and Appendages Disorders" were analyzed based on patient demographics, the types of CADRs, suspected drugs, outcome, and latency period. Read More

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http://dx.doi.org/10.1002/prp2.469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415979PMC
April 2019
2 Reads

Primary immunodeficiencies in adults.

Authors:
Jiří Litzman

Vnitr Lek 2019 ;65(2):109-116

In contrast to general opinion, the issue of primary immunodeficiency is far from just a pediatric medicine; a large number of patients with primary immunodefciencies are not only treated, but also diagnosed in adulthood. The most important manifestation of these diseases are serious, unusual or ill-treatable infections. Some primary immune deficiency diseases manifest themselves in adulthood - mainly common variable immunodeficiency (CVID) and Goods syndrome (hypogammaglobulinemia with thymoma). Read More

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January 2019
1 Read

Reporting through smartphone application results in detailed data on acquired and hereditary angioedema attacks.

Allergy 2019 Mar 25. Epub 2019 Mar 25.

HAE Centre Denmark, Odense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.1111/all.13792DOI Listing
March 2019
1 Read

Association of positive and negative autologous serum skin test responses with clinical features of chronic spontaneous urticaria in Asian patients: A systematic review and meta-analysis.

Exp Ther Med 2019 Apr 13;17(4):2603-2613. Epub 2019 Feb 13.

Department of Dermatology, No. 1 Hospital of China Medical University and Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, Liaoning 110001, P.R. China.

Previous studies on the correlation between positive autologous serum skin test (ASST) responses and the clinical features of patients with chronic spontaneous urticaria (CSU) have provided conflicting results. To evaluate the significance of ASST responses in CSU, a variety of databases were searched from inception to March 2018 to identify relevant studies on CSU. Data were analyzed with use of the Cochrane Collaboration's Review Manager 5. Read More

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http://dx.doi.org/10.3892/etm.2019.7266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425266PMC
April 2019
1 Read

Predictive factors for progression to chronicity or recurrence after the first attack of acute urticaria in preschool-age children.

Allergol Immunopathol (Madr) 2019 Mar 20. Epub 2019 Mar 20.

Introduction And Objectives: Preschool-aged group is frequently affected by urticaria, and infections are the most frequently documented factors that cause acute urticaria in children. This prospective study was designed to investigate the underlying factors of acute urticaria in under five-year-old children and to describe predictive factors for progression to chronicity or recurrence after the first attack.

Patients And Methods: Children younger than five years of age with acute urticaria were recruited between July 2015 and July 2016. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.010DOI Listing
March 2019
3 Reads

Rare presentation of anaphylaxis: pancake syndrome.

BMJ Case Rep 2019 Mar 21;12(3). Epub 2019 Mar 21.

Department of Adult Allergy, Guy's and St Thomas' NHS Foundation Trust, London, UK.

A 43-year-old woman presented with oral discomfort, sneezing, urticaria, eyelid angioedema, abdominal pain, diarrhoea, dyspnoea and wheeze soon after eating a Japanese flour pancake (okonomiyaki, containing wheat, egg, yam, pork, prawn and squid). Subsequent analysis of the flour used in the pancake revealed the presence of (4500 mites/g). The patient tested positive for specific IgE to (15. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22885
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http://dx.doi.org/10.1136/bcr-2018-228854DOI Listing
March 2019
7 Reads

Indirect comparison of intravenous vs. subcutaneous C1-inhibitor placebo-controlled trials for routine prevention of hereditary angioedema attacks.

Allergy Asthma Clin Immunol 2019 7;15:13. Epub 2019 Mar 7.

AMF Consulting, Inc., Los Angeles, CA USA.

Introduction: For prophylaxis of hereditary angioedema (HAE) attacks, replacement therapy with human C1-inhibitor (C1-INH) treatment is approved and available as intravenous [C1-INH(IV)] (Cinryze) and subcutaneous [C1-INH(SC)] HAEGARDA preparations. In the absence of a head-to-head comparative study of the two treatment modalities, an indirect comparison of data from 2 independent but similar clinical trials was undertaken.

Methods: Two similar randomized, double-blind, placebo-controlled, crossover studies were identified which evaluated either C1-INH(SC) (COMPACT; NCT01912456; 16 weeks) or C1-INH(IV) (CHANGE; NCT01005888; 14 weeks) vs. Read More

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http://dx.doi.org/10.1186/s13223-019-0328-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407188PMC
March 2019
4 Reads

Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study.

Acta Med Port 2019 Feb 28;32(2):133-140. Epub 2019 Feb 28.

Novartis Farma - Produtos Farmacêuticos, S.A. Porto Salvo. Portugal.

Introduction: There is a paucity of information regarding chronic urticaria patients' care in a real-world setting. The objective of this study was to report and evaluate the baseline characteristics of Portuguese chronic urticaria patients refractory to H1-antihistamines included in the AWARE study.

Material And Methods: This is a non-interventional cohort study. Read More

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http://dx.doi.org/10.20344/amp.9496DOI Listing
February 2019
3 Reads

Ticagrelor-induced Angioedema After Percutaneous Coronary Intervention in a Patient with a History of Ischemic Stroke and Low Response to Clopidogrel: A Rare Dilemma.

Cureus 2018 Dec 11;10(12):e3720. Epub 2018 Dec 11.

Cardiology, Saint Vincent Hospital, Worcester, USA.

Dual antiplatelet therapy (DAPT) is widely recognized as the mainstay of treatment after percutaneous coronary intervention (PCI). Premature discontinuation may pose a risk of in-stent thrombosis, acute myocardial infarction, and death. With the increased usage of antiplatelet agents, increased attention has been drawn to their potential allergic reactions. Read More

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http://dx.doi.org/10.7759/cureus.3720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415980PMC
December 2018
1 Read

Serum fetuin-A, tumor necrosis factor alpha and C-reactive protein concentrations in patients with hereditary angioedema with C1-inhibitor deficiency.

Orphanet J Rare Dis 2019 Mar 18;14(1):67. Epub 2019 Mar 18.

Department of Family Medicine, Semmelweis University, Budapest POB 2, Kútvölgyi str. 4, Budapest, H-1125, Hungary.

Background And Aims: Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is characterized by localized, non-pitting, and transient swelling of submucosal or subcutaneous region. Human fetuin-A is a multifunctional glycoprotein that belongs to the proteinase inhibitor cystatin superfamily and has structural similarities to the high molecular weight kininogen. Fetuin-A is also known a negative acute phase reactant with anti-inflammatory characteristics. Read More

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http://dx.doi.org/10.1186/s13023-019-0995-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423823PMC
March 2019
1 Read

Incidence, clinical features, and outcomes of food allergy in children who underwent liver transplant: 16-year experience.

Pediatr Transplant 2019 Mar 18:e13399. Epub 2019 Mar 18.

Department of General Surgery and Transplant Surgery, Başkent University Hospital, Ankara, Turkey.

Food allergies often develop after liver transplant, especially in young children. However, data are scarce on clinical characteristics and patient outcomes. When we evaluated our pediatric liver transplant patients over a 16-year period, food allergy incidence was 8% (19/236 patients). Read More

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http://dx.doi.org/10.1111/petr.13399DOI Listing
March 2019
1 Read

Anesthetic Management of a Patient With Hereditary Angioedema for Oral Surgery.

Anesth Prog 2019 ;66(1):30-32

Department of Dental Anesthesiology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

Hereditary angioedema (HAE) is a rare genetic disease that results from deficiency or dysfunction of C1 inhibitor (C1-INH). This disease is characterized by sudden attacks of angioedema. When edema occurs in the pharynx or larynx, it can lead to serious airway compromise, including death. Read More

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http://www.anesthesiaprogress.org/doi/10.2344/anpr-65-04-01
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http://dx.doi.org/10.2344/anpr-65-04-01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424165PMC
January 2019
8 Reads

Hereditary angioedema in Austria: prevalence and regional peculiarities.

J Dtsch Dermatol Ges 2019 Apr 18;17(4):416-423. Epub 2019 Mar 18.

Department of Dermatology and Venereology, Medical University of Graz, Austria.

Background: Data on the prevalence and clinical features of Austrian patients with hereditary angioedema (HAE) with C1-inhibitor (C1-INH) deficiency (HAE-1) or dysfunction (HAE-2) are lacking.

Methods: Current baseline data were collected in a national survey. The records of HAE patients at the Medical University of Graz were analyzed with regard to clinical characteristics. Read More

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http://dx.doi.org/10.1111/ddg.13815DOI Listing
April 2019
1 Read

Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition.

J Struct Biol 2019 Mar 12. Epub 2019 Mar 12.

Global Blood Therapeutics, South San Francisco, CA 94080, United States.

Plasma kallikrein (pKal) is a serine protease responsible for cleaving high-molecular-weight kininogen to produce the pro-inflammatory peptide, bradykinin. Unregulated pKal activity can lead to hereditary angioedema (HAE) following excess bradykinin release. HAE attacks can lead to a compromised airway that can be life threatening. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10478477193004
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http://dx.doi.org/10.1016/j.jsb.2019.03.001DOI Listing
March 2019
16 Reads

Effective treatment of different H1-antihistamine-refractory chronic urticaria phenotypes with omalizumab.

Turk Pediatri Ars 2018 Dec 1;53(4):250-254. Epub 2018 Dec 1.

Department of Pediatrics, Division of Pediatric Allergy and Immunology, Adnan Menderes University School of Medicine, Aydın, Turkey.

Omalizumab is a recombinant humanized monoclonal anti-IgE antibody. Until now, the efficiency of omalizumab in chronic spontaneous urticaria has been demonstrated in several studies. However in the literature, data showing the efficiency of omalizumab in different phenotypes of H1-antihistamine-refractory chronic urticaria are limited. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2016.4042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408194PMC
December 2018
1 Read

Ranolazine, ACE Inhibitors, and Angiotensin Receptor Blockers.

Am J Med 2019 Mar 11. Epub 2019 Mar 11.

Johns Hopkins University, Towson, MD 21204.

Background: Ranolazine is an anti-angina agent with many metabolites creating the potential for off-target effects. FDA reviews sometimes contain clinically relevant data not found in other sources.

Methods: We reanalyzed data in an FDA review of the placebo-controlled MERLIN trial of ranolazine to display differences in adverse event rates graphically. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.02.032DOI Listing
March 2019
2 Reads

Angioedema due to acquired C1-inhibitor deficiency: spectrum and treatment with C1-inhibitor concentrate.

Orphanet J Rare Dis 2019 Mar 13;14(1):65. Epub 2019 Mar 13.

Department of Medical Psychology and Medical Sociology, Johannes Gutenberg University, Mainz, Germany.

Background: Acquired angioedema due to C1-inhibitor (C1-INH) deficiency (AAE-C1-INH) is a serious condition that may result in life-threatening asphyxiation due to laryngeal edema. It is associated with malignant B-cell lymphoma and other disorders. The purpose of this study was to describe the characteristics and associated disorders of patients with AAE-C1-INH and assess the efficacy of plasma-derived C1-INH concentrate (pdC1-INH) in the treatment of AAE-C1-INH. Read More

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http://dx.doi.org/10.1186/s13023-019-1043-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417199PMC
March 2019
2 Reads

Cyclooxygenase selectivity and chemical groups of non-steroidal anti-inflammatory drugs and the frequency of reporting hypersensitivity reactions: a case/non-case study in VigiBase.

Fundam Clin Pharmacol 2019 Mar 12. Epub 2019 Mar 12.

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, the Netherlands.

The reporting of hypersensitivity reactions (HSRs) among non-steroidal anti-inflammatory drugs (NSAIDs) according to cyclooxygenase (COX) selectivity and chemical groups has not been published yet in one study. This study assessed the reporting frequency of HSRs for NSAIDs based on their relative inhibitory potency towards COX enzymes and chemical groups, including the presence/absence of a functional sulfonamide group, in strata of 5 years after market authorization. A case/non-case study was performed among Individual Case Safety Reports (ICSRs) with NSAIDs as suspected drugs in VigiBase, the WHO spontaneous reporting database. Read More

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http://dx.doi.org/10.1111/fcp.12463DOI Listing
March 2019
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The identification and chromatographic separation of a new highly analogous impurity of the active pharmaceutical ingredient icatibant.

Eur J Pharm Sci 2019 Apr 6;132:121-124. Epub 2019 Mar 6.

Institute of Chemistry - Analytical Chemistry for Health and Environment, University of Universitaetplatz 1, Graz, Austria.

Icatibant is a peptidomimetic drug serving as a bradykinin-receptor antagonist and is approved in Europe and the United States for the treatment of hereditary angioedema attacks. We have detected an impurity with a high structural similarity to icatibant in pharmaceutical dosage forms using an optimized chromatographic method based on reversed phase high performance liquid chromatography with UV detection. The abundance of the impurity was around 1% relative to the icatibant peak following storage at room temperature for 1 month, and raised up to ~16% upon temperature stressing at 100 °C. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.03.003DOI Listing
April 2019
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Genetic Variation of Kallikrein-Kinin System and Related Genes in Patients With Hereditary Angioedema.

Front Med (Lausanne) 2019 21;6:28. Epub 2019 Feb 21.

Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil.

Hereditary angioedema (HAE) is an autosomal dominant disease caused by C1-INH deficiency due to mutations in (C1-INH-HAE) in most of the cases, or by specific mutations in factor XII gene, (F12-HAE). Identification of polymorphisms in the genes encoding proteins from key pathways driving HAE can help to understand how genetic diversity contributes to its phenotypic variability. Here, 15 genes related to the Kallikrein-Kinin System (KKS) were analyzed by next generation sequencing in 59 patients with C1-INH-HAE or F12-HAE from Brazil, Denmark and Spain, and 19 healthy relatives in a total of 31 families. Read More

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https://www.frontiersin.org/article/10.3389/fmed.2019.00028/
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http://dx.doi.org/10.3389/fmed.2019.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393376PMC
February 2019
4 Reads

Structural studies of plasmin inhibition.

Biochem Soc Trans 2019 Mar 5. Epub 2019 Mar 5.

ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne 3800, Australia

Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm), and it plays a crucial role in fibrinolysis as well as wound healing, immunity, tissue remodeling and inflammation. Binding to the targets via the lysine-binding sites allows for Plg activation by plasminogen activators (PAs) present on the same target. Cellular uptake of fibrin degradation products leads to apoptosis, which represents one of the pathways for cross-talk between fibrinolysis and tissue remodeling. Read More

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http://dx.doi.org/10.1042/BST20180211DOI Listing
March 2019
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Hemifacial angioedema following alteplase for acute stroke.

Pract Neurol 2019 Mar 5. Epub 2019 Mar 5.

Division of Pulmonary, Critical Care and Sleep Medicine, Bridgeport Hospital, Yale-New Haven Health System, Bridgeport, Connecticut, USA.

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http://dx.doi.org/10.1136/practneurol-2018-002112DOI Listing
March 2019
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New approach in prophylactic treatment of a challenged HAE patient.

BMJ Case Rep 2019 Mar 4;12(3). Epub 2019 Mar 4.

Department of Dermatology and Allergy Center, University Hospital of Odense, Odense, Denmark.

Hereditary angioedema (HAE) is a relapsing swelling disorder which can cause severe pain, affect quality of life and potentially be life threatening with involvement of the airways. We present a 34-year-old immigrant who suffered from very frequent and severe HAE attacks. The attacks often involved the face, mouth and the airways. Read More

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http://dx.doi.org/10.1136/bcr-2018-227061DOI Listing
March 2019
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Possible donor-dependent differences in efficacy of fresh frozen plasma for treatment of ACE inhibitor-induced angioedema.

J Allergy Clin Immunol Pract 2019 Mar 2. Epub 2019 Mar 2.

Division of Hospital Medicine, Department of Medicine, Saint Louis Veterans Affairs Medical Center, Saint Louis, Mo; Department of Medicine, Washington University School of Medicine, Saint Louis, Mo. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.02.027DOI Listing
March 2019
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Age Characteristics and Concomitant Diseases in Patients with Angioedema.

Open Access Maced J Med Sci 2019 Feb 13;7(3):369-372. Epub 2019 Feb 13.

Department of Microbiology and Immunology, Faculty of Pharmacy, Medical University-Plovdiv, Plovdiv, Bulgaria.

Background: Angioneurotic oedema (AE) is an unpredictable and dangerous disease directly threatening the patient's life due to a sudden onset of upper respiratory tract obstruction. The disease is associated with various causes and triggering factors, but little is known about the conditions that accompany AE.

Aim: The study aims to determine the age-specificities and the spectrum of concomitant diseases in patients with AE. Read More

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http://dx.doi.org/10.3889/oamjms.2019.121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390151PMC
February 2019
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Angioedema - Our Experience Focused On Socio-Demographic, Etiological and Clinical Characteristics of the Condition and Its Management.

Open Access Maced J Med Sci 2019 Feb 28;7(3):341-346. Epub 2019 Jan 28.

Medical University, Plovdiv, Bulgaria.

Background: Angioedema (AE) is acute oedema of the skin and mucous surfaces, involving the respiratory and gastrointestinal tracts. AE could be a life-threatening medical condition. Regardless of its growing clinical importance, many aspects of its aetiology and pathogenesis remain poorly understood. Read More

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http://dx.doi.org/10.3889/oamjms.2019.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390144PMC
February 2019
6 Reads