8,458 results match your criteria Angioedema


Final Results of a Phase I/II Trial of the Combination Bendamustine and Rituximab With Temsirolimus (BeRT) in Relapsed Mantle Cell Lymphoma and Follicular Lymphoma.

Hemasphere 2020 Jun 8;4(3):e398. Epub 2020 Jun 8.

Department of Medicine III, Ludwig - Maximilians-University Munich, Germany.

In this phase I/II study, we explored the combination of Temsirolimus with Bendamustine and Rituximab (BeRT) in patients with relapsed or refractory (r/r) follicular lymphoma (FL) or mantle cell lymphoma (MCL). Patients with 1 to 3 previous therapies received Bendamustine (90 mg/m, day 1 + 2) and Rituximab (375 mg/m, day 1) with Temsirolimus in doses from 25 to 75 mg in phase I and 50 mg Temsirolimus in phase II, added on day 1, 8, 15 of a 28 days cycle. The primary endpoint of the phase II was ORR at the end of treatment. Read More

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http://dx.doi.org/10.1097/HS9.0000000000000398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306311PMC

Monoclonal gammopathy with significance: case series and literature review.

Neth J Med 2020 Jul;78(4):191-195

Department of Nephrology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.

Monoclonal gammopathy of undetermined significance (MGUS) is considered an asymptomatic precursor of malignant lymphoid disorders. This case series and literature review shows that these monoclonal gammopathies can cause significant morbidity. We describe a patient with angioedema due to acquired C1-esterase inhibitor deficiency, a patient with cryoglobulinemia type II causing skin vasculitis and glomerulonephritis, and a patient with glomerulonephritis and nephrotic syndrome - all caused by a monoclonal gammopathy that can be classified as MGUS. Read More

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Urticaria and angioedema as a prodromal cutaneous manifestation of SARS-CoV-2 (COVID-19) infection.

Authors:
Khalid Hassan

BMJ Case Rep 2020 Jul 7;13(7). Epub 2020 Jul 7.

Loch Lomond Surgery, 75 Bank Street, Alexandria, Scotland

This is a case of a patient who presented with an urticarial rash 48 hours before developing symptoms of fever and a continuous cough. She subsequently developed angioedema of her lips and hands before testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Urticarial rashes occurring 48 hours before other symptoms of COVID-19 infection have been documented. Read More

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http://dx.doi.org/10.1136/bcr-2020-236981DOI Listing

A clozapine-induced hypersensitivity reaction.

Ir J Psychol Med 2020 Jun 17;37(2):122-125. Epub 2017 Oct 17.

Department of Psychiatry, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland.

A 57-year-old female patient with a diagnosis of schizo-affective disorder since 1986 was commenced on clozapine due to persistent positive and negative psychotic symptoms in September 2014. After commencement of clozapine she was delusion free and demonstrated an improvement in negative symptoms. Three months after commencement of clozapine she developed a hypersensitivity reaction. Read More

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http://dx.doi.org/10.1017/ipm.2017.45DOI Listing

Gastrointestinal Angioedema as a Side Effect of Alteplase for Acute Stroke.

J Vasc Interv Radiol 2020 Jul 4. Epub 2020 Jul 4.

Departments of Neurology, Alpert Medical School at Brown University, Providence, Rhode Island.

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http://dx.doi.org/10.1016/j.jvir.2020.04.003DOI Listing

Idiopathic Nonhistaminergic Acquired Angioedema in a Patient with COVID-19.

Ann Allergy Asthma Immunol 2020 Jul 1. Epub 2020 Jul 1.

Section of Rheumatology, Allergy, & Immunology, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1016/j.anai.2020.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327466PMC

Every angioedema following urticaria is not histamine-mediated.

Ann Allergy Asthma Immunol 2020 Jul 1. Epub 2020 Jul 1.

Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul, Turkey.

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http://dx.doi.org/10.1016/j.anai.2020.06.035DOI Listing

Evaluation of Dermatology Consultations in a Tertiary Care Centre Emergency Service.

Sisli Etfal Hastan Tip Bul 2020 18;54(2):197-200. Epub 2020 May 18.

Department of Dermatology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.

Objectives: The primary objective of our study was to investigate the profile of patients visiting our hospital's emergency department and underwent dermatology consultation.

Methods: In this study, we reviewed electronic medical records of 444 consultations from the emergency department over a period from 01.05. Read More

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http://dx.doi.org/10.14744/SEMB.2018.72473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326684PMC

Recurrent angioedema, Guillain-Barré, and myelitis in a girl with systemic lupus erythematosus and CD59 deficiency syndrome.

Auto Immun Highlights 2020 Dec 29;11(1). Epub 2020 Jun 29.

Department of Pediatric Neurology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: CD59 deficiency is a congenital mutation disorder in complement pathway which can present with various manifestations.

Case Presentation: Herein, we presented an adolescent 16-years-old girl with recurrent attacks of Guillain-Barre in early childhood and then recurrent attacks of angioedema, paresthesia, and myelitis. Finally, she presented with quadriplegia, malar rash, proteinuria, lymphopenia, and high titer of antinuclear antibody. Read More

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http://dx.doi.org/10.1186/s13317-020-00132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322911PMC
December 2020

Pharmacokinetics, Efficacy and Safety of a Plasma-Derived VWF/FVIII Concentrate (Formulation V) in Pediatric Patients with von Willebrand Disease (SWIFTLY-VWD Study).

J Blood Med 2020 22;11:213-225. Epub 2020 Jun 22.

Clinical Development, CSL Behring, Marburg, Germany.

Purpose: Formulation V (VONCENTO) is a plasma-derived high-concentration/low-volume, high-purity von Willebrand factor (VWF)/factor VIII (FVIII) concentrate, originally indicated for von Willebrand disease (VWD) in adults and adolescents. This multicenter, open-label study (SWIFTLY-VWD) evaluated the pharmacokinetics (PK), as well as hemostatic efficacy and safety, of Formulation V in pediatric patients (<12 years) with severe VWD requiring treatment or prophylaxis of bleedings.

Methods: PK investigations were performed following one dose of Formulation V at Day 1 and 180. Read More

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http://dx.doi.org/10.2147/JBM.S236789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319533PMC

Pearls and pitfalls: Cold-induced urticaria.

Allergy Asthma Proc 2020 Jul;41(4):301-304

Division of Allergy and Immunology, Naval Medical Center Portsmouth, Portsmouth, Virginia.

Cold-induced urticaria can take place either due to direct cold exposure, cryoglobulinemia, or genetic component (such as cryopyrin-associated periodic syndrome), which leads to the rapid onset of urticaria and/or angioedema. It is more common in younger patients and more likely to affect females compared with males. To increase awareness of such systemic reactions of anaphylaxis and provide a focused review of the differential diagnosis, underlying mechanisms, broad workup, and management of this disease process for allergy/immunology fellows, residents, general physicians, and general practitioners. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200033DOI Listing

Novel Therapeutic Approaches And Targets For Treatment Of Chronic Urticaria: New Insights And Promising Targets For A Challenging Disease.

Curr Pharm Biotechnol 2020 Jun 30. Epub 2020 Jun 30.

Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona. Italy.

Background: Chronic spontaneous urticaria (CSU) is a disease characterized by the onset of wheals and/or angioedema over 6 weeks. The pathophysiology for CSU is very complex, involving mast cells and basophils with a multitude of inflammatory mediators. For many years the treatment of CSU has been based on the use of antihistamines, steroids and immunosuppressive agents with inconstant and frustrating results. Read More

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http://dx.doi.org/10.2174/1389201021666200630140137DOI Listing

Experience with Omalizumab for the treatment of chronic spontaneous urticaria in a tertiary center: real life experience.

Cutan Ocul Toxicol 2020 Jul 7:1-5. Epub 2020 Jul 7.

Department of Dermatology and Venereology, Ege University Faculty of Medicine, Izmir, Turkey.

Purpose: Chronic spontaneous urticaria (CSU) is defined as urticaria and/or angioedema that appears spontaneously due to known or unknown causes and lasts for at least 6 weeks. Omalizumab, an anti-IgE antibody that binds circulating free IgE, has recently emerged as a promising treatment for CSU, a condition which impairs patients' quality of life. We aimed to contribute real life data by reporting our experience with omalizumab in the treatment of intractable CSU. Read More

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http://dx.doi.org/10.1080/15569527.2020.1787432DOI Listing

FACTORS CONTRIBUTING TO CHRONIC URTICARIA/ANGIOEDEMA AND NUMMULAR ECZEMA RESOLUTION - WHICH FINDINGS ARE CRUCIAL?

Acta Clin Croat 2019 Dec;58(4):595-603

1Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

When working with dermatology patients, the question sometimes arises which diagnostic tests and tools should be used for workup, particularly in cases of chronic urticaria (CU) and discoid nummular eczema, where the treatment of associated systemic diseases and infections may be crucial for patient outcome. The aim was to investigate retrospectively the influence of associated diseases on skin disease outcomes based on medical records of CU and nummular eczema patients in comparison to controls. We included patients admitted to our Dermatology Department over a 6-year period and analyzed their laboratory findings, related factors and outcomes recorded after two years of workup and treatment. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314308PMC
December 2019

Patient involvement in preparing health research peer-reviewed publications or results summaries: a systematic review and evidence-based recommendations.

Res Involv Engagem 2020 24;6:34. Epub 2020 Jun 24.

Envision the Patient - Envision Pharma Group, Suite 5.11, 5th Floor, 1 Lyric Square, London, W6 0NB UK.

Background: There are increasing calls for patient involvement in sharing health research results, but no evidence-based recommendations to guide such involvement. Our objectives were to: (1) conduct a systematic review of the evidence on patient involvement in results sharing, (2) propose evidence-based recommendations to help maximize benefits and minimize risks of such involvement and (3) conduct this project with patient authors.

Methods: To avoid research waste, we verified that no systematic reviews were registered or published on this topic. Read More

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http://dx.doi.org/10.1186/s40900-020-00190-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313171PMC

Study of angiopoietin and plasminogen genes in hereditary angioedema.

Rev Assoc Med Bras (1992) 2020 Apr;66(4):502-506

. Programa de Pós-Graduação em Medicina Interna e Ciências da Saúde. Complexo Hospital de Clínicas,Universidade Federal do Paraná - UFPR, Curitiba, PR, Brasil.

Objective: To investigate the presence of the Angiopoietin 1 (ANGPT1) and Plasminogen (PLG) mutations in patients with Hereditary Angioedema (HAE) and normal C1 esterase inhibitor (C1-INH) levels, who do not harbor the F12 gene mutation.

Methods: Patients clinically diagnosed with HAE but without C1-INH deficiency or dysfunction and F12 gene mutation were evaluated. DNA extraction, quantification, and dilution were performed at a concentration of 100 ng/µL, followed by a DNA amplification (PCR) for molecular evaluation of exon 2 of the ANGPT1 gene and exon 9 of the PLG gene for identification of mutations c. Read More

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http://dx.doi.org/10.1590/1806-9282.66.4.502DOI Listing

KAMBÔ: an Amazonian enigma.

J Venom Res 2020 26;10:13-17. Epub 2020 May 26.

Department of Zoology, Taubaté University, Taubaté, São Paulo State, Brazil.

The secretions of the Giant Monkey Frog are used by populations in the Amazon regions (mainly the indigenous Katukinas and Kaxinawás). The so-called "toad vaccine" or "kambô" is applied as a medication for infections and to prevent diseases, and also as physical and mental invigorator, and analgesic. Since the 1980s, researchers and companies have been interested in the composition of these secretions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284396PMC

Comparative safety of high-dose versus standard-dose influenza vaccination in patients with end-stage renal disease.

Vaccine 2020 Jul 19;38(33):5178-5186. Epub 2020 Jun 19.

Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

Background: High-dose influenza vaccine (HDV) is an alternative vaccination strategy in patients with end-stage renal disease (ESRD), though the safety of HDV has not been evaluated in this population. The objective of this study was to estimate the relative occurrence of adverse vaccine reactions in patients with ESRD following vaccination with HDV compared with standard-dose influenza vaccine (SDV).

Methods: Using data from the United States Renal Data System, we identified patients with ESRD aged ≥ 65 years at influenza vaccination during yearly influenza seasons from 2010 through 2016. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332402PMC

Direct and indirect action modes of acetylcholine in cholinergic urticaria.

Authors:
Yoshiki Tokura

Allergol Int 2020 Jun 18. Epub 2020 Jun 18.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address:

Cholinergic urticaria (CholU) manifests small, itchy and/or painful wheals occurring upon perspiration and mechanically involving acetylcholine (Ach). Although a considerable number of studies have been conducted, the pathomechanisms underlying perspiration-associated release of histamine remain to be elucidated. We have proposed that CholU can be categorized into two major subtypes: Ach-indirectly induced, sweat allergic type and Ach-directly induced, depressed sweating type. Read More

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http://dx.doi.org/10.1016/j.alit.2020.05.006DOI Listing

An Unusual Presentation of Hereditary Angioedema Type II with Amnesia, Poor Concentration and Headache.

Ann Allergy Asthma Immunol 2020 Jun 18. Epub 2020 Jun 18.

Department of Pediatrics, University of Illinois College of Medicine, Chicago, IL 60612; Department of Medicine, University of Illinois College of Medicine, Chicago, IL 60612.

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http://dx.doi.org/10.1016/j.anai.2020.06.024DOI Listing

Angioedema after t-PA Infusion.

N Engl J Med 2020 Jun;382(25):2449

Hospital de Santa Maria, Lisbon, Portugal

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http://dx.doi.org/10.1056/NEJMicm1913828DOI Listing

Gleich syndrome: a systematic review.

Int J Dermatol 2020 Jun 18. Epub 2020 Jun 18.

Dermatology Department, Faculty of Medicine, Balamand University, Saint Georges Hospital UMC, Beirut, Lebanon.

Characterized chiefly by hypereosinophilia and angioedema, Gleich syndrome is a rare disorder with unclear clinical and therapeutic findings. Other symptoms include increased IgM levels, weight gain, fever, and urticaria. Herein we review Gleich syndrome and assess clinical features, epidemiology, and treatment options. Read More

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http://dx.doi.org/10.1111/ijd.14963DOI Listing

Increasing Allergy-related Emergency Department Visits in the United States, 2007-2015.

J Allergy Clin Immunol Pract 2020 Jun 15. Epub 2020 Jun 15.

Department of Emergency Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, United States.

Background: Allergic reactions, angioedema, and anaphylaxis are commonly treated in the emergency department (ED). Contemporary evidence suggests that these conditions may be increasing in the US.

Objective: Our objective was to evaluate the contemporary epidemiology and trends of ED visits for allergic reactions, angioedema, and anaphylaxis in the United States (US) from 2007 to 2015. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.05.056DOI Listing

Hereditary Alpha-Tryptasemia: UK Prevalence and variability in disease expression.

J Allergy Clin Immunol Pract 2020 Jun 15. Epub 2020 Jun 15.

Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, University of Manchester, UK. Electronic address:

Background: Hereditary Alpha-Tryptasemia (HAT) is a genetic trait caused by an increased alpha-tryptase TPSAB1 gene copy number. Basal serum mast cell tryptase is typically ≥8.0ng/ml. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.05.057DOI Listing

What lies downstream? A case of superior vena cava syndrome presenting in the dermatology clinic: A case report.

SAGE Open Med Case Rep 2020 20;8:2050313X20919618. Epub 2020 May 20.

University Hospital of Northern British Columbia, Prince George, BC, Canada.

A 75-year-old female presented with a 1 year history of a firm, diffusely swollen, and erythematous facial plaque. She had preceding unsuccessful investigations and treatment for angioedema. Full-skin examination revealed multiple prominent varicosities on the chest and abdomen. Read More

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http://dx.doi.org/10.1177/2050313X20919618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249544PMC

Current status of the management of hereditary angioedema in China: a patient-based, cross-sectional survey.

Eur J Dermatol 2020 Apr;30(2):169-176

Department of Allergy, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing 100730.

Background: Hereditary angioedema (HAE) is a rare, inherited disorder characterized by unpredictable and recurrent cutaneous and mucosal oedema.

Objectives: This study aimed to identify the current status of HAE management in China.

Materials And Methods: An internet-based survey was sent to 129 patients with type 1 and 2 HAE diagnosed between 1983 and 2017; a total of 107 patients provided complete disease management information. Read More

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http://dx.doi.org/10.1684/ejd.2020.3758DOI Listing

[A case of angioedema caused by medical gypsum].

Authors:
L L Qiu Y L Bi Y H Hu

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 05;38(5):388

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http://dx.doi.org/10.3760/cma.j.cn121094-20190919-00386DOI Listing

Association Between Self-Reported Dental Hygiene Practices and Dental Procedure-Related Recurrent Angioedema Attacks in HAE Subjects: A Multi-Center Survey.

J Allergy Clin Immunol Pract 2020 Jun 10. Epub 2020 Jun 10.

Division of Immunology/Allergy, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH. Electronic address:

Background: Hereditary angioedema (HAE) symptoms may be triggered by dental procedures thereby complicating dental care in individuals affected by the condition.

Objective: This study investigated the self-perceived dental care needs, perceived susceptibility to acute angioedema (AE) attacks after dental procedures and dental care behavior of HAE patients.

Methods: A self-administered semi-structured web-based questionnaire was distributed to 250 adult HAE patients (Type-1 or -2; 88% Type-1) and 256 matched non-HAE controls. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.05.041DOI Listing

Clinical predictive factors of unresponsiveness to omalizumab in patients with chronic spontaneous urticaria.

Br J Dermatol 2020 Jun 12. Epub 2020 Jun 12.

Hospices Civils de Lyon, Clinical immunology and Allergology, Pierre-Bénite, France.

Chronic spontaneous urticaria (CSU) is an inflammatory disease which is characterized by spontaneous appearance of wheals (hives), angioedema or both for at least six weeks. Approximately 10% of patients suffering from CSU are unresponsive to second-generation H1-antihistamines. For these severe cases, recommendation is a treatment by omalizumab (OMZ) -a humanized anti-IgE monoclonal antibody. Read More

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http://dx.doi.org/10.1111/bjd.19312DOI Listing

Pregnancy-Induced Exacerbation of Hereditary Angioedema in a Multiparous Caucasian Female.

Cureus 2020 May 7;12(5):e8006. Epub 2020 May 7.

Allergy and Immunology, Kansas University Medical Center, Overland Park, USA.

Hereditary angioedema (HAE) manifests due to a deficiency of the C1-esterase inhibitor and can present with life-threatening swelling of multiple body regions such as the face, hands, upper respiratory tract, and intestinal walls. The present case describes the manifestation and symptomatic exacerbation of HAE in a multiparous Caucasian female. Very few trials and cases are available on HAE exacerbations during pregnancy, and our case describes the timeline and treatment in order to add to the clinical awareness of the disease. Read More

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http://dx.doi.org/10.7759/cureus.8006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279689PMC

Urticaria (angioedema) and COVID-19 infection.

J Eur Acad Dermatol Venereol 2020 Jun 11. Epub 2020 Jun 11.

Bradford Teaching Hospitals NHS Foundation Trust, Bradford Royal Infirmary, Bradford, UK.

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http://dx.doi.org/10.1111/jdv.16721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307033PMC

Articular angioedema in patients with chronic spontaneous urticaria is frequently misdiagnosed as arthritis.

J Allergy Clin Immunol Pract 2020 Jun 7. Epub 2020 Jun 7.

The Proteomic and Flow Cytometry Unit, Allergy and Clinical Immunology, Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2020.05.043DOI Listing

Hereditary angioedema in children and adolescents - A consensus update on therapeutic strategies for German-speaking countries.

Pediatr Allergy Immunol 2020 Jun 10. Epub 2020 Jun 10.

Allergology Unit, Department of Dermatology, University Hospital, Zürich, Switzerland.

Background/methods: At a consensus meeting in August 2018, pediatricians and dermatologists from German-speaking countries discussed the therapeutic strategy for the treatment of pediatric patients with types I and II hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) for Germany, Austria, and Switzerland, taking into account the current marketing approval status. HAE-C1-INH is a rare disease that usually presents during childhood or adolescence with intermittent episodes of potentially life-threatening angioedema. Diagnosis as early as possible and an optimal management of the disease are important to avoid ineffective therapies and to properly treat swelling attacks. Read More

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http://dx.doi.org/10.1111/pai.13309DOI Listing

Proteomic Analysis of the Acid-Insoluble Fraction of Whole Saliva from Patients Affected by Different Forms of Non-histaminergic Angioedema.

J Clin Immunol 2020 Jun 10. Epub 2020 Jun 10.

Dept of Life and Environmental Sciences, University of Cagliari, 09042, Monserrato, CA, Italy.

We analyzed by bidimensional electrophoresis the acid-insoluble fraction of saliva from three classes of angioedema patients and a healthy control group, highlighting significant variations of several normalized spot volumes. Characterization of the corresponding proteins was performed by in-gel tryptic digestion of the spots, followed by high-resolution HPLC-ESI-MS/MS analysis of tryptic mixtures. By this strategy, 16 differentially-expressed proteins among two or more groups were identified. Read More

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http://dx.doi.org/10.1007/s10875-020-00802-wDOI Listing

Hereditary angioedema C1-esterase inhibitor replacement therapy and coexisting autoimmune disorders: findings from a claims database.

Allergy Asthma Clin Immunol 2020 27;16:42. Epub 2020 May 27.

AMF Consulting Inc., Los Angeles, CA USA.

In this letter to the editor, we present results of claims data analysis. This claims data analysis supports a hypothesis that in patients with hereditary angioedema due to C1-esterase inhibitor (C1-INH) deficiency, the occurrence and/or symptomatology of coexisting autoimmune disease may be positively influenced by a replacement therapy with plasma derived C1-INH. Read More

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http://dx.doi.org/10.1186/s13223-020-00439-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254637PMC

Co-occurrence between C1 esterase inhibitor deficiency and autoimmune disease: a systematic literature review.

Allergy Asthma Clin Immunol 2020 27;16:41. Epub 2020 May 27.

CSL Behring, Marburg, Germany.

Background: Hereditary angioedema (HAE) is caused by a SERPING1 gene defect resulting in decreased (Type I) or dysfunctional (Type II) C1 esterase inhibitor (C1-INH). The prevalence of autoimmune diseases (ADs) in patients with HAE appears to be higher than the general population. A systematic literature review was conducted to examine the co-occurrence between HAE and ADs. Read More

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http://dx.doi.org/10.1186/s13223-020-00437-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254644PMC

Contact urticaria/angioedema caused by nickel from metal dental braces.

Contact Dermatitis 2020 Jun 8. Epub 2020 Jun 8.

Unit of Dermatology, Hospital Universitario San Cecilio, Granada, Spain.

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http://dx.doi.org/10.1111/cod.13634DOI Listing

Acquired angioedema induced by angiotensin-converting enzyme inhibitors - experience of a hospital-based allergy center.

Exp Ther Med 2020 Jul 27;20(1):68-72. Epub 2020 Jan 27.

Dermatology Research Laboratory, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Angiotensin-converting enzyme inhibitors (ACEIs) represent an important group of pharmacological compounds, largely prescribed for more than 30 years. They have been extensively evaluated in clinical trials, demonstrating significant reduction of morbidity and mortality of patients with cardiovascular diseases, mainly high blood pressure, myocardial infarction, heart failure and stroke. Besides their beneficial effects and a general good safety profile, it was proven that ACEIs might also induce adverse effects in some patients, most notably angioedema (AE) and chronic cough. Read More

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http://dx.doi.org/10.3892/etm.2020.8474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271703PMC

Checkpoint Inhibition Causing Complete Remission of Metastatic Combined Hepatocellular-Cholangiocarcinoma after Hepatic Resection.

Case Rep Oncol 2020 Jan-Apr;13(1):478-484. Epub 2020 Apr 30.

Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.

Combined hepatocellular-cholangiocarcinoma (CHC) is a rare type of primary liver cancer, speculated to arise from hepatic progenitor cells, and with a worse prognosis than hepatocellular carcinoma (HCC). Serum alpha-fetoprotein (AFP) levels may be one prognostic factor. It has been suggested that checkpoint inhibition might be useful in the treatment of HCC where there is an increased expression of PD-1 and PD-L1 in the microenvironment. Read More

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http://dx.doi.org/10.1159/000507320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250374PMC

Chronic Urticaria in Children: an Update on Diagnosis and Treatment.

Curr Allergy Asthma Rep 2020 Jun 6;20(8):31. Epub 2020 Jun 6.

Dept. of Pediatrics, Div. of Allergy and Immunology, National Jewish Health, Denver, CO, 80206, USA.

Purpose Of Review: Both adults and children are frequently affected by symptoms of itchy urticarial lesions that cause considerable distress and impact nearly all their daily activities. A comprehensive history is critical to identify the etiology in patients who have chronic spontaneous urticaria (CSU) (those with symptoms for > 6 weeks) and is more important than extensive laboratory serum tests. Unfortunately, most of the current treatment guidelines have been based on data from adult studies since there is rare data on children. Read More

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http://dx.doi.org/10.1007/s11882-020-00929-1DOI Listing

A lesson from a saboteur: High-MW kininogen impact in coronavirus-induced disease 2019.

Br J Pharmacol 2020 Jun 4. Epub 2020 Jun 4.

Department of Pharmacy (DIFARMA), University of Salerno, Fisciano, Italy.

The newly identified coronavirus SARS-CoV-2 that spread from China is causing the pandemic COVID-19 with a fatality rate from 5-15%. It causes fever, cough, myalgia, fatigue up to dyspnoea, responsible for hospitalization and artificial oxygenation. SARS-CoV-2 infects human cells using ACE2, the transmembrane protease serine 2 (TMPRSS2) and the SARS-CoV-2 main protease (M ). Read More

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http://dx.doi.org/10.1111/bph.15154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300552PMC

Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and ARB induced angioedema.

Clin Pharmacol Ther 2020 Jun 4. Epub 2020 Jun 4.

Division of Population Health and Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, U.K.

Angioedema occurring in the head and neck region is a rare and sometimes life-threatening adverse reaction to angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB). Only few studies have investigated the association of common variants with this extreme reaction, but none have explored the combined influence of rare variants yet. Adjudicated cases of ACEI- or ARB-induced angioedema (ACEI-AE, ARB-AE) and controls were recruited at five different centres. Read More

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http://dx.doi.org/10.1002/cpt.1927DOI Listing

Legends of Allergy and Immunology: Allen Kaplan, M.D.

Authors:
Kusumam Joseph

Allergy 2020 Jun 4. Epub 2020 Jun 4.

Scientific Director, BioCryst Pharmaceuticals Inc, United States.

Dr. Allen Kaplan's contributions to our specialty of Allergy and Clinical Immunology span a period of 50 years from his fellowship at The National Institutes of Health beginning in 1967 through his closure of the laboratory at The Medical University of South Carolina in 2017. His research focus has always been on the pathogenesis and treatment of urticaria and angioedema. Read More

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http://dx.doi.org/10.1111/all.14431DOI Listing

Reply to Comment on "An Unusual Case of Acquired Angioedema and Monoclonal Gammopathy of Renal Significance in a Middle-Aged Caucasian Female".

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620929478

Lynchburg Nephrology Physicians, Lynchburg, VA, USA.

We sincerely thank Dr Andrew Whyte, who keenly reviewed our case report and came up with critical reasoning to justify his thoughts and critique with regard to our published article, "An Unusual Case of Acquired Angioedema and Monoclonal Gammopathy of Renal Significance in a Middle-Aged Caucasian Female." We agree with the author that hypocomplementemic urticarial vasculitis can be a reasonable contender as a diagnosis in this case. There are indeed some features in this case that do not entirely fit either classic presentation of acquired angioedema or hypocomplementemic urticarial vasculitis. Read More

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http://dx.doi.org/10.1177/2324709620929478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273557PMC