8,954 results match your criteria Angioedema

Analysis of cold activation of the contact system in hereditary angioedema with normal C1 inhibitor.

Mol Immunol 2021 Jun 18;136:150-160. Epub 2021 Jun 18.

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States.

Hereditary angioedema (HAE) attacks are caused by excessive activation of the contact system. Understanding how the contact system is activated in HAE, especially in patients with normal C1 inhibitor (HAEnCI), is essential to effectively treat this disease. Contact system activation involves the cleavage of several proteins including Factor XII (FXII), high molecular weight kininogen (HK), prekallikrein, sgp120 (ITIH4) and C1 inhibitor (C1-INH) before the subsequent generation of bradykinin that mediates HAE. Read More

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Difficult airway due to angioedema caused after 14 years of taking enalapril.

Rev Esp Anestesiol Reanim 2021 Jun 17. Epub 2021 Jun 17.

Departamento de Anestesiología, Hospital Universitario Vall d'Hebron, Barcelona, España. Electronic address:

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Paracetamol Allergy: A Case of a 9-Year-Old Female with a History of Atopy.

Pediatr Allergy Immunol Pulmonol 2021 Jun;34(2):80-82

Department of Pediatrics and Department of Allergy and Immunology, Hospital Santa Luzia de Viana do Castelo, Viana do Castelo, Portugal.

We describe a rare case involving paracetamol, a commonly used drug worldwide. Increased paracetamol consumption increases the risk of adverse drug reactions. This is a case of a 9-year-old girl who visited the emergency department due to sudden onset sneezing, nasal itching, urticaria, and angioedema after paracetamol ingestion. Read More

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Factor XII(a) inhibitors: a review of the patent literature.

Expert Opin Ther Pat 2021 Jun 18. Epub 2021 Jun 18.

Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstraße 48, 48149, Münster, Germany.

Introduction: : Blood coagulation factor XII (FXII) is an emerging and potentially safe drug target, which dysregulation is associated with thrombosis, hereditary angioedema, and (neuro)inflammation. At the same time, FXII-deficiency is practically asymptomatic. Industrial and academic institutions have developed a number of potential therapeutic agents targeting either FXII zymogen or its active form FXIIa for the treatment of thrombotic and inflammatory conditions associated with the activity of this enzyme. Read More

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The challenges of chronic urticaria part 2: Pharmacological treatment, chronic inducible urticaria, urticaria in special situations.

World Allergy Organ J 2021 Jun 3;14(6):100546. Epub 2021 Jun 3.

Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico.

This is Part 2 of an updated follow-up review of the World Allergy Organization (WAO) position paper on the diagnosis and treatment of urticaria and angioedema. Since that document was published, new advances in the understanding of the pathogenesis of chronic urticaria, and greater experience with the use of biologics in patients with severe refractory disease, mainly omalizumab, have been gained. For these reasons, WAO decided to initiate an update targeted to general practitioners around the world, incorporating the most recent information on epidemiology, immunopathogenesis, comorbidities, quality of life, clinical case presentations, and the management of chronic spontaneous and chronic inducible urticaria, and urticaria in special situations such as childhood and pregnancy. Read More

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Serum Human β-Defensin 2 Is Increased in Angioedema Accompanying Chronic Spontaneous Urticaria.

Int Arch Allergy Immunol 2021 Jun 17:1-6. Epub 2021 Jun 17.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.

Introduction: Chronic spontaneous urticaria (CSU) is a common cutaneous disease caused by mast-cell degranulation. Human β-defensin 2 (HBD2) is a well-known antimicrobial peptide that is also a pruritogen inducing vascular permeability via non-IgE-mediated mast-cell degranulation.

Objective: We investigated the associations between serum HBD2 levels and the clinical characteristics of CSU patients. Read More

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Angioedema: differential diagnosis and acute management.

Postgrad Med 2021 Jun 16. Epub 2021 Jun 16.

Carolina Asthma & Allergy Center; Charlotte, NC.

A clinical vignette illustrates a typical presentation of a patient seeking help for acute angioedema. Despite the risks of SARS-CoV-2 (COVID-19) exposure, it is critical to evaluate patients with acute angioedema in person, because there is always the potential for angioedema to progress to the head, neck, or lungs, which can rapidly compromise the airways and require immediate intervention to avoid potential asphyxiation. There are three mediators of angioedema, histamine, leukotriene, or bradykinin, each requiring different management. Read More

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Berotralstat (BCX7353) is a novel oral prophylactic treatment for hereditary angioedema: Review of phase II and III studies.

Allergy Asthma Proc 2021 Jun 14. Epub 2021 Jun 14.

Background: Hereditary angioedema (HAE) is a rare genetic disorder characterized by unpredictable and potentially life-threatening episodes of swelling in various parts of the body. These attacks can be painful and debilitating, and affect apatient's quality of life. Every patient who experiences an attack should be treated with on-demand medication to mitigateattack severity and duration. Read More

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Five Years of Sacubitril/Valsartan-a Safety Analysis of Randomized Clinical Trials and Real-World Pharmacovigilance.

Cardiovasc Drugs Ther 2021 Jun 14. Epub 2021 Jun 14.

Beth Israel Lahey Health, Department of Cardiovascular Medicine, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA, 01805, USA.

Purpose: In PARADIGM-HF, sacubitril/valsartan showed a significant reduction in mortality and hospitalization for patients with heart failure with reduced ejection fraction. Despite proven efficacy, sacubitril/valsartan has moderate uptake in clinical practice. This study explores the safety profile of sacubitril/valsartan by comparing adverse events in RCT and real-world use. Read More

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Effect of omalizumab for autoimmune progesterone dermatitis refractory to bilateral oophorectomy: a case report.

Allergy Asthma Clin Immunol 2021 Jun 13;17(1):58. Epub 2021 Jun 13.

Division of Internal Medicine, Northern Ontario School of Medicine, Sudbury, ON, Canada.

Background: Autoimmune progesterone dermatitis (APD) is a rare skin condition caused by sensitivity to high levels of progesterone secreted during the luteal phase of the menstrual cycle. This may be due to various pathophysiological mechanisms including a Type I and Type IV hypersensitivity reaction. Here we present the case of a patient with APD whose episodic flares were controlled by the addition of omalizumab, after a bilateral oophorectomy failed to resolve her symptoms. Read More

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Reply to "Proposal for a new classification of vibratory urticaria/angioedema".

J Allergy Clin Immunol Pract 2021 Jun;9(6):2543-2544

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany (corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. Electronic address:

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Proposal for a new classification of vibratory urticaria/angioedema.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2542-2543

Dermatology Department, Hospital del Mar IMIM, Universitat Autònoma, Barcelona, Spain.

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The Road to Better Urticaria and Angioedema Management.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2243-2244

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

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What's New in the Treatment of Urticaria and Angioedema.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2170-2184

Department for Children and Adolescents, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, Frankfurt, Germany.

Chronic urticaria and angioedema are diseases often managed by Allergy and Immunology specialists. Recent international guidelines have outlined a stepwise approach to management of patients using dose escalation of second-generation antihistamines followed by use of omalizumab and finally cyclosporine in more refractory cases. In select patients (those with refractory chronic urticaria), nonbiologic alternative medications with anti-inflammatory or immunosuppressant activity may be considered. Read More

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Triggers of Exacerbation in Chronic Urticaria and Recurrent Angioedema-Prevalence and Relevance.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2160-2168

Clinical Faculty, University of Texas Southwestern Medical School, Allergy and Asthma Specialists, Dallas, Texas. Electronic address:

Patients with urticaria and angioedema often have triggers that cause an outbreak or a swelling episode or worsen their chronic condition. Exploring these factors with each patient may result in better understanding and control of their disease. Patients should be advised to avoid known triggers, if feasible, or prepare to prevent or control an exacerbation with appropriate pretreatment if avoidance is not possible. Read More

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How to Measure Disease Activity, Impact, and Control in Patients with Recurrent Wheals, Angioedema, or Both.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2151-2157

Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Chronic spontaneous urticaria and chronic inducible urticaria are characterized by wheals, angioedema, or both, whereas other conditions such as hereditary angioedema present only with angioedema. The unpredictability of outbreaks, disfigurement, pruritus, and associated sleep and work disturbance can cause a significant impact on quality of life (QoL). Significant breakthroughs in the understanding of these conditions in recent years have led to the development of novel therapies. Read More

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Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-Dose and Multiple-Dose Studies) to Determine the Safety, Tolerability, and Pharmacokinetics of Orally Administered LX9211 in Healthy Participants.

Clin Ther 2021 Jun 6. Epub 2021 Jun 6.

Lexicon Pharmaceuticals Inc, The Woodlands, Texas. Electronic address:

Purpose: For neuropathic pain, current therapies do not provide relief for most patients; less than half achieve a 50% pain reduction. Current analgesics have adverse effects. We present 2 Phase I studies of LX9211, a new small-molecule AP2-associated kinase 1 inhibitor with preclinical effectiveness in pain relief. Read More

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Angioedema in a patient with COVID-19 who received depot olanzapine pamoate: Diagnostic dilemma posed.

Indian J Psychiatry 2021 Jan-Feb;63(1):115-116. Epub 2021 Feb 15.

Department of Psychiatry, All India Institute of Medical Sciences, Patna, Bihar, India.

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February 2021

Effectiveness of Lanadelumab in Hereditary Angioedema patients with Normal C1 Inhibitor and FXII mutation.

Ann Allergy Asthma Immunol 2021 May 31. Epub 2021 May 31.

Department of Internal Medicine, National Reference Centre for Bradykinin-Mediated Angioedemas (CREAK), Grenoble University-Hospital, Grenoble, France.

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Hair-Dye-Related Accidental Poisoning and Death.

Cureus 2021 Apr 21;13(4):e14607. Epub 2021 Apr 21.

Pulmonary and Critical Care Medicine, Veterans Affairs Medical Center, Washington, USA.

Para phenylenediamine (PPD) is a common component of hair dye as well as temporary tattoos and is a well-known cause of type 4 hypersensitivity reactions from topical exposure. While there have been several cases reported in the literature describing toxicities following ingestion, there are a paucity of reports of severe systemic disease following topical exposure. Cases of PPD ingestion have been reported to present with angioedema-like reactions, often progressing to rhabdomyolysis and renal failure. Read More

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High Estrogen States in Hereditary Angioedema: a Spectrum.

Clin Rev Allergy Immunol 2021 Jun 1. Epub 2021 Jun 1.

Wright State Physicians Health Center, Department of Pharmacology & Toxicology, 725 University Blvd, Fairborn, OH, USA.

Sex differences have been well documented within hereditary angioedema (HAE) over the past several decades. Females often experience more frequent and more intense attacks compared to their male counterparts. Additionally, elevated estrogen levels-as seen in pregnancy and use of oral contraceptives-is a widely known trigger for angioedema attacks. Read More

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The Genetics of Hereditary Angioedema: A Review.

J Clin Med 2021 May 9;10(9). Epub 2021 May 9.

Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.

Hereditary angioedema is a rare inherited disorder characterized by recurrent episodes of the accumulation of fluids outside of the blood vessels, causing rapid swelling of tissues in the hands, feet, limbs, face, intestinal tract, or airway. Mutations in SERPING1, the gene that encodes C1-INH (C1 esterase inhibitor), are responsible for the majority of cases of hereditary angioedema. C1 esterase inhibitor (C1-INH) is a major regulator of critical enzymes that are implicated in the cascades of bradykinin generation, which increases the vascular permeability and allows the flow of fluids into the extracellular space and results in angioedema. Read More

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Awake intubations in the emergency department: A report from the National Emergency Airway Registry.

Am J Emerg Med 2021 May 15;49:48-51. Epub 2021 May 15.

Department of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St. Boston, MA, 02215, United States. Electronic address:

Objective: To describe awake intubation practices in the emergency department (ED) and report success, complications, devices used, and rescue techniques using multicenter surveillance.

Methods: We analyzed data from the National Emergency Airway Registry (NEAR). Patients with an awake intubation attempt between January 1, 2016 and December 31, 2018 were included. Read More

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Treatment of hereditary angioedema: When the goal is having a normal life.

J Allergy Clin Immunol 2021 May 28. Epub 2021 May 28.

Department of Medicine, Ribeirão Preto Medical School, University of São Paulo.São Paulo, Brazil.

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Ethnicity and Antiphospholipid Syndrome in Israel.

Arthritis Care Res (Hoboken) 2021 May 31. Epub 2021 May 31.

Clinical Immunology, Angioedema and Allergy Unit, The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel.

Background: The Antiphospholipid Syndrome (APS) is an acquired coagulopathy associated with the presence of antiphospholipid antibodies. Whether ethnicity modulates APS clinical course is not known. The aim of our study was to assess the interplay ethnicity and APS in Israel. Read More

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Cold Urticaria. Characterizing the population from an urticaria outpatient clinic.

Actas Dermosifiliogr 2021 May 28. Epub 2021 May 28.

Immunoallergology Department, Hospital de Santa Maria - Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.

Introduction: Cold Urticaria (ColdU) is a type of chronic inducible urticaria (CIndU) where recurrent pruritic wheals and/or angioedema occur after exposure to cold stimulus. Although it usually only affects exposed areas, systemic reactions can occur in severe cases. In this study, we seek to characterize the ColdU cases within our Centre's population of patients. Read More

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Roles of Immune Cells in Hereditary Angioedema.

Clin Rev Allergy Immunol 2021 May 29. Epub 2021 May 29.

Department of Translational Medical Sciences, University of Naples Federico II, 80131, Naples, Italy.

Hereditary angioedema (HAE) is a rare genetic disease, characterized by recurrent and unexpected potentially life-threatening mucosal swelling. HAE may be further classified into HAE with C1-inhibitor deficiency (C1-INH-HAE) and HAE with normal C1-INH activity (nlC1-INH-HAE), mostly due to mutations leading to increased vascular permeability. Recent evidence implicates also the innate and adaptive immune responses in several aspects of angioedema pathophysiology. Read More

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Nailfold capillaroscopic abnormalities in angioedema with eosinophilia.

Allergol Int 2021 May 25. Epub 2021 May 25.

Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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Consensus on treatment goals in hereditary angioedema: a global Delphi initiative.

J Allergy Clin Immunol 2021 May 25. Epub 2021 May 25.

US HAEA Angioedema Center, Department of Medicine, University of California, San Diego, 8899 University Center Lane, La Jolla, CA 92122, USA; San Diego VA Healthcare, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.

Background: Hereditary angioedema (HAE) is a rare, life-threatening genetic disorder characterized by recurrent episodes of subcutaneous or submucosal angioedema. The ultimate goals of treatment for HAE remain ill-defined.

Objective: The aim of this Delphi process was to define the goals of HAE treatment and to examine which factors should be considered when assessing disease control and normalization of the patient's life. Read More

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Approach to Children with Hives.

Pediatr Ann 2021 May 1;50(5):e191-e197. Epub 2021 May 1.

Urticaria (or hives) is a pruritic and erythematous skin rash. Angioedema commonly occurs with urticaria. The term "chronic urticaria" is used when hives are present for more than 6 weeks. Read More

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