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    [Observation of systemic adverse reactions by specific immunotherapy and analysis of risk factors in allergic rhinitis].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Nov;52(11):801-805
    Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
    Objective: To investigate the systemic adverse effects of specific subcutaneous immunotherapy (SCIT) in patients with allergic rhinitis (AR) and explore the possible risk factors. Methods: A retrospective study was conducted on AR patients who underwent SCIT from January 2014 to January 2017 in Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University. For patients with adverse reactions, the detailed medical history during treatment was reviewed. Read More

    Safety of the neprilysin/renin-angiotensin system inhibitor LCZ696.
    Oncotarget 2017 Oct 31;8(47):83323-83333. Epub 2017 May 31.
    Department of Cardiology, Qilu Hospital of Shandong University, Ji'nan, 250012, PR China.
    Objectives: The combined neprilysin/rennin-angiotensin system inhibitor sacubitril/valsartan (LCZ696) has shown its superiority over ACEI/ARB therapy. In view of the existing concern of its adverse effects, we aimed to provide evidence of the safety of the new drug.

    Results: A total of 6 randomized trials with 11,821 subjects were included in this analysis. Read More

    Genetic Determinants of C1 Inhibitor Deficiency Angioedema Age of Onset.
    Int Arch Allergy Immunol 2017 Nov 9. Epub 2017 Nov 9.
    Department of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
    Background: In view of the large heterogeneity in the clinical presentation of hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE), great efforts are being made towards detecting measurable biological determinants of disease severity that can help to improve the management of the disease. Considering the central role that plasma kallikrein plays in bradykinin production, we investigated the contribution of the functional polymorphism KLKB1-428G/A to the disease phenotype.

    Methods: We studied 249 C1-INH-HAE patients from 114 European families, and we explored possible associations of C1-INH-HAE clinical features with carriage of KLKB1-428G/A, combined or not with that of the functional F12-46C/T polymorphism. Read More

    CRP is linked to disease activity, impact and response to treatment in patients with chronic spontaneous urticaria.
    Allergy 2017 Nov 12. Epub 2017 Nov 12.
    Charité - Universitätsmedizin Berlin, Department of Dermatology and Allergology, Berlin, Germany.
    Background: Elevated levels of C-reactive protein (CRP), a sensitive marker of inflammation, have been consistently reported in chronic spontaneous urticaria. Here, we retrospectively analyzed data from 1,253 CSU patients from two centers to answer the following questions: 1) What is the prevalence of elevated levels of CRP in CSU? 2) Why do CSU patients show elevated levels of CRP? 3) Are elevated CRP levels relevant?

    Methods: Serum levels of CRP were measured by the nephelometric method. We collected information regarding various laboratory tests including ESR, CBC with differential, D-dimer, fibrinogen, C3, C4, IL-6 etc. Read More

    Hereditary Angioedema with Normal C1 Inhibitor and F12 Mutations in 42 Brazilian Families.
    J Allergy Clin Immunol Pract 2017 Nov 8. Epub 2017 Nov 8.
    Division of Clinical Immunology, Faculdade de Medicina ABC, Santo André, SP, Brazil. Electronic address:
    Background: Hereditary angioedema (HAE) with normal C1 inhibitor (C1-INH) is a rare condition with clinical features similar to those of HAE with C1-INH deficiency. Mutations in the F12 gene have been identified in subsets of patients with HAE with normal C1-INH, mostly within families of European descent.

    Objectives: Our aim was to describe clinical characteristics observed in Brazilians from 42 families with HAE and F12 gene mutations (FXII-HAE), and to compare these findings with those from other populations. Read More

    Management of pediatric 'cannot intubate, cannot oxygenate'.
    Acute Med Surg 2017 Oct 18;4(4):462-466. Epub 2017 Aug 18.
    Department of Emergency and Critical Care MedicineJapanese Red Cross Society Kyoto Daini HospitalKyotoJapan.
    Case: "Cannot intubate, cannot oxygenate" (CICO) is a rare, life-threatening situation. We describe a pediatric case of CICO and highlight some educational points.A 3-year-old boy who collapsed in the bathtub came to our emergency department. Read More

    Hypocomplementemic Urticarial Vasculitis Syndrome with Membranous Nephropathy: Case Report.
    J Korean Med Sci 2017 Dec;32(12):2064-2068
    Division of Rheumatology, Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
    Urticarial vasculitis is a rare disorder that principally manifests with recurrent urticarial, sometimes hemorrhagic, skin lesions and/or angioedema. Its clinical presentation is not always limited to cutaneous lesions and it can potentially affect other organs, such as the joints, lungs, kidneys, and eyes. Systemic involvement can either be present at the onset of disease or develop over time. Read More

    Pharmacotherapy for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema: A Systematic Review.
    Otolaryngol Head Neck Surg 2017 Nov 1:194599817737974. Epub 2017 Nov 1.
    1 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
    Objective Angioedema is a potentially life-threatening complication of angiotensin-converting enzyme inhibitor (ACEI) use, occurring in up to 0.5% of users. Although the pathophysiology of ACEI-induced angioedema is attributable to elevated serum bradykinin, standard management typically includes corticosteroids and antihistamines. Read More

    Hereditary angioedema: Assessing the hypothesis for underlying autonomic dysfunction.
    PLoS One 2017 6;12(11):e0187110. Epub 2017 Nov 6.
    Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
    Background: Attacks of Hereditary Angioedema due to C1-inhibitor deficiency (C1-INH-HAE)are often triggered by stressful events/hormonal changes.

    Objective: Our study evaluates the relationship between autonomic nervous system (ANS) and contact/complement system activation.

    Methods: Twenty-three HAE patients (6 males, mean age 47. Read More

    Efficacy and safety of omalizumab for the treatment of refractory chronic spontaneous urticaria in Japanese patients: Subgroup analysis of the phase 3 POLARIS study.
    Allergol Int 2017 Nov 1. Epub 2017 Nov 1.
    Novartis Pharma AG, Basel, Switzerland. Electronic address:
    Background: Omalizumab, a humanized anti-IgE monoclonal antibody, proved efficacious and well tolerated in patients with chronic spontaneous urticaria (CSU) refractory to H1 antihistamines (H1AH) in the POLARIS study (NCT02329223), a randomized, double-blind, placebo-controlled trial in East Asian patients. However, data in Japanese patients, who have specific baseline characteristics (e.g. Read More

    Icatibant as a Potential Treatment of Life-Threatening Alteplase-Induced Angioedema.
    J Stroke Cerebrovasc Dis 2017 Oct 30. Epub 2017 Oct 30.
    Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
    Severe orolingual angioedema is a life-threatening complication of alteplase treatment for acute ischemic stroke that occurs during alteplase infusion or in the first 2 hours afterward. Currently, there are no proven therapies, although glucocorticoids, antihistamines, and adrenaline are sometimes used. Intubation is required if significant airway compromise supervenes. Read More

    Comparison of the Frequency of Angioedema Attack, before and during Pregnancy, in a Patient with Type I Hereditary Angioedema.
    Intern Med 2017 Nov 1. Epub 2017 Nov 1.
    Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Japan.
    The patient was a 38-year-old Japanese woman who had been diagnosed with hereditary angioedema type I at 7 years of age based on her family history. She had undergone four pregnancies. She gave birth to a healthy baby girl after her first pregnancy and had reported few episodes of angioedema. Read More

    Clinical Features of Hereditary and Mast Cell-mediated Angioedema Focusing on the Differential Diagnosis in Japanese Patients.
    Intern Med 2017 Nov 1. Epub 2017 Nov 1.
    Medical Corporation SHOWAKAI, Japan.
    Background The present study was designed to identify the clinical characteristics that permit the differential diagnosis of hereditary angioedema (HAE) and mast cell-mediated angioedema (Mast-AE) during the first consultation. Methods The medical histories and laboratory data of 46 patients with HAE and 41 patients with Mast-AE were compared. Results The average age of onset in the HAE group (19. Read More

    Retrospective study of hypersensitivity reactions to chemotherapeutic agents in a thoracic oncology service.
    J Clin Pharm Ther 2017 Nov 1. Epub 2017 Nov 1.
    Aix Marseille Univ, AP-HM, Oncopharma, Hôpital Nord, Marseille, France.
    What Is Known And Objective: With the increasing use of cancer chemotherapy agents, hypersensitivity reactions are commonly encountered. The allergic clinical symptoms are variable and unpredictable. The aim of this study was to identify the characteristics of hypersensitivity reactions and to assess the value of skin tests for platinum salts and pemetrexed in the treatment of patients with non-small cell lung cancers or malignant pleural mesothelioma. Read More

    A rash decision. The hazards of the wrongful use of adrenaline.
    Rom J Anaesth Intensive Care 2017 Oct;24(2):163-166
    Cardiology Departament, Hospital de Santa Marta, Centro Hospitalar Lisboa Central, Lisbon, Portugal.
    Anaphylaxis is life-threatening and should be addressed urgently. Its treatment is not without side effects and an accurate diagnosis must be made to prevent potential harm by the wrongful use of medication. A 46-year-old woman with hypertension treated with angiotensin converting enzyme inhibitor (ACEI) presented to the emergency department with non-pitting oedema of the face and limbs. Read More

    Multiple doses of icatibant used during pregnancy.
    Allergy Rhinol (Providence) 2017 Oct;8(3):178-181
    Background: Hereditary angioedema (HAE) is a life-long disease that often manifests by puberty. Treatment of attacks is essential to improve quality of life and to decrease morbidity and mortality. During pregnancy, treatment is limited because multiple treatment options, including icatibant, are not approved for use during pregnancy. Read More

    Pathogenesis of Drug Induced Non-Allergic Angioedema: A Review of Unusual Etiologies.
    Cureus 2017 Aug 23;9(8):e1598. Epub 2017 Aug 23.
    Internal Medicine, Pramukhswami Medical College, Anand,Gujarat.
    Angioedema is the swelling of mucosal and sub-mucosal tissue. Typically, it manifests as the swelling of the face, lips, and tongue. Angioedema can be severe and life threatening when it involves the respiratory tract. Read More

    The safety profile of parecoxib for the treatment of postoperative pain: a pooled analysis of 28 randomized, double-blind, placebo-controlled clinical trials and a review of over 10 years of postauthorization data.
    J Pain Res 2017 10;10:2451-2459. Epub 2017 Oct 10.
    Safety Surveillance and Risk Management, Worldwide Safety and Regulatory, Worldwide Research and Development, Pfizer, New York, NY, USA.
    Background: Nonselective, nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors are associated with safety issues including cardiovascular, renal, and gastrointestinal (GI) events.

    Objective: To examine the safety of parecoxib, a COX-2 inhibitor, for the management of postoperative pain.

    Design: Pooled analysis of 28 placebo-controlled trials of parecoxib and review of postauthorization safety data. Read More

    Perindopril arginine and amlodipine besylate for hypertension: a safety evaluation.
    Expert Opin Drug Saf 2017 Oct 31:1-10. Epub 2017 Oct 31.
    a Department of Biomedical Sciences , Pacific Northwest University of Health Sciences , Yakima , WA , USA.
    Introduction: Controlling blood pressure is a global health priority; single-pill antihypertensive combinations may improve adherence, persistence, and outcomes. Areas covered: A novel combination of perindopril arginine and amlodipine besylate was recently approved. A systematic review of the literature revealed its most common adverse effects as: peripheral edema (depending on the dose of amlodipine, but attenuated by perindopril), cough, dizziness and hypotension. Read More

    Endocan: A Novel Marker of Endothelial Dysfunction in C1-Inhibitor-Deficient Hereditary Angioedema.
    Int Arch Allergy Immunol 2017 24;174(2):104-107. Epub 2017 Oct 24.
    Immunology and Allergy Unit, Yedikule Education and Training Hospital, Istanbul University, Istanbul, Turkey.
    Background: Hereditary angioedema (HAE) related to C1-inhibitor deficiency is a rare autosomal dominant disorder. Vascular cell adhesion molecules (VCAM) are known as endothelial activation markers. Endocan (also called ESM-1) is proposed as an endothelial dysfunction indicator. Read More

    Omalizumab Rapidly Improves Angioedema-Related Quality of Life in Adult Patients with Chronic Spontaneous Urticaria: X-ACT Study Data.
    Allergy 2017 Oct 23. Epub 2017 Oct 23.
    Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.
    Background: The X-ACT study aims to examine the effect of omalizumab treatment on quality of life (QoL) in chronic spontaneous urticaria (CSU) patients with angioedema refractory to high doses of H1 -antihistamines.

    Methods: In X-ACT, a phase III, double-blind, placebo-controlled study, CSU patients (18-75 years) with ≥4 angioedema episodes during the 6 months before inclusion were randomized (1:1) to receive omalizumab 300 mg or placebo every 4 weeks for 28 weeks. Angioedema-related QoL, skin-related QoL impairment, and psychological well-being were assessed. Read More

    Health-related quality of life in Danish children with hereditary angioedema.
    Allergy Asthma Proc 2017 Nov;38(6):440-446
    Background: The potentially life-threatening disease hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) can have considerable impact on the health-related quality of life (HRQoL) in adult patients. Half the patients with C1-INH-HAE develop symptoms before the age of 10 years. However, the HRQoL in children with C1-INH-HAE is almost unexplored. Read More

    [Is it possible for chronic urticaria diagnostic approach to be simplified? A clinical data checklist].
    Rev Alerg Mex 2017 Jul-Sep;64(3):309-326
    Universidad Espíritu Santo, Samborondón, Ecuador.
    Background: Existing clinical guidelines do not offer an efficient alternative for the collection of data on relevant clinical traits during history and physical of the patient with chronic urticaria.

    Objective: Our aim was to provide a clinical data checklist together with its guide to allow for thorough information to be obtained and for a physical exam that identifies the main features and triggering factors of the disease to be carried out.

    Methods: A search was conducted for relevant literature on chronic urticaria in Medline, the Cochrane library and PubMed. Read More

    An open-label study to evaluate the long-term safety and efficacy of lanadelumab for prevention of attacks in hereditary angioedema: design of the HELP study extension.
    Clin Transl Allergy 2017 6;7:36. Epub 2017 Oct 6.
    Division of Clinical Immunology and Allergy, Department of Medicine, Icahn School of Medicine at Mount Sinai, 5 East 98th Street 11th Floor, New York, NY 10029 USA.
    Background: Hereditary angioedema (HAE) is characterized by recurrent attacks of subcutaneous or submucosal edema. Attacks are unpredictable, debilitating, and have a significant impact on quality of life. Patients may be prescribed prophylactic therapy to prevent angioedema attacks. Read More

    Checklist for a complete chronic urticaria medical history: an easy tool.
    World Allergy Organ J 2017 3;10(1):34. Epub 2017 Oct 3.
    Respiralab, Respiralab Research Group, Guayaquil, Ecuador.
    Background: Existing guidelines do not offer a quick, efficient alternative to the patient's recollection of relevant clinical features during anamnesis and physical examination for chronic urticaria (CU). This study aimed to identify specific items reflecting the main characteristics of CU that should be included in a comprehensive medical history for patients with CU. We also aimed to clarify possible eliciting factors for CU to support accurate diagnosis of the disease. Read More

    Autoimmune Progesterone Dermatitis: A Diagnosis to Consider in a Patient With Cyclical Cutaneous Eruptions.
    J Drugs Dermatol 2017 Oct;16(10):1040-1042
    Autoimmune progesterone dermatitis (APD) is a cyclical cutaneous reaction to progesterone, with symptoms that typically begin 3-10 days before the onset of menstrual flow and end 1-2 days into menses. The symptoms vary in severity from barely visible to anaphylaxis, but most often include an eczematous eruption, erythema multiforme, urticaria, folliculitis, and angioedema. This is a rare disorder with only a handful of documented cases. Read More

    Facial Edema in an Elderly Man: An Unusual Presentation of Nonepisodic Angioedema with Eosinophilia.
    Case Rep Dermatol 2017 Sep-Dec;9(3):164-168. Epub 2017 Sep 12.
    Department of Dermatology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.
    Nonepisodic angioedema with eosinophilia (NEAE) is a rare allergic disease with a young Japanese and East Asian female predominance. NEAE features transient, nonrecurrent angioedema and peripheral blood eosinophilia without visceral organ involvement. Angioedema in NEAE occurs on the extremities, while the trunk and face are rarely involved. Read More

    Angioedema Associated With Long-Acting Injectable Paliperidone Palmitate: A Case Report.
    J Clin Psychopharmacol 2017 Dec;37(6):730-732
    2nd Department of Psychiatry "Attikon" General Hospital National and Kapodistrian University of Athens Medical School Athens, Greece Department of Biology University of Crete Heraklion Crete Greece Institute of Molecular Biology and Biotechnology Foundation for Research and Technology-Hellas, Heraklion, Crete Greece Laboratory of Hematology and Blood Transfusion Department "Attikon" General Hospital National and Kapodistrian University of Athens Medical School Athens, Greece Psychiatric Department of General Hospital Panarkadiko "Evangelistria," Tripoli, Greece 1st Department of Psychiatry Eginition Psychiatric Hospital National and Kapodistrian University of Athens Medical School Athens, Greece 2nd Department of Psychiatry "Attikon" General Hospital National and Kapodistrian University of Athens Medical School Athens, Greece University of Athens Medical School Athens, Greece Clinical Microbiology Laboratory Attikon University Hospital Athens, Greece 2nd Department of Psychiatry "Attikon" General Hospital National and Kapodistrian University of Athens Medical School Athens, Greece

    Angiotensin-converting enzyme inhibitor-induced angioedema: A review of the literature.
    J Clin Hypertens (Greenwich) 2017 Oct 10. Epub 2017 Oct 10.
    Department of Medicine, Division of Allergy, Immunology and Infectious Diseases, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
    According to the National Health and Nutrition Examination Survey 2012, one third of antihypertensive prescriptions in the United States in the past decade were for angiotensin-converting enzyme inhibitors (ACEIs). An important and serious side effect of ACEIs is angioedema caused by a reduction in bradykinin degradation. In a national medical chart abstraction study conducted at the US Veterans Affairs Health Care System in 2008, 0. Read More

    Hydroxychloroquine desensitization, an effective method to overcome hypersensitivity-a multicenter experience.
    Lupus 2017 Jan 1:961203317735185. Epub 2017 Jan 1.
    2 Clinical Immunology, Angioedema and Allergy Unit, The Zabludowicz Center for Autoimmune Diseases, 26744 Sheba Medical Center, Tel Hashomer , Israel.
    Hydroxychloroquine (HCQ) is widely used to treat autoimmune/rheumatic diseases such as systemic lupus erythematosus (SLE). The immune modulation effects of HCQ have been highlighted as beneficial for maintaining remission of SLE as well as ameliorating skin, joint and other manifestations. Moreover, HCQ exposure for prolonged periods as well as during pregnancy is considered safe, therefore it is recommended for the vast majority of SLE patients. Read More

    Complete kinetic follow-up of symptoms and complement parameters during a hereditary angioedema attack.
    Allergy 2017 Oct 7. Epub 2017 Oct 7.
    Research Laboratory, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
    We studied the kinetics of C1-inhibitor (C1-INH) and other complement parameters in a self-limited edematous attack (EA) in a patient with hereditary angioedema due to C1-INH deficiency to better understand the pathomechanism of the evolution, course, and complete resolution of EAs. C1-INH concentration and functional activity (C1-INHc+f ), C1(q,r,s), C3, C4, C3a, C4a, C5a, and SC5b-9 levels were measured in blood samples obtained during the 96-hour observation period. The highest C1-INHc+f , C4, and C1(q,r,s) levels were measured at baseline, and their continuous decrease was observed during the entire observation period. Read More

    Persistent oromandibular dystonia and angioedema secondary to haloperidol.
    BMJ Case Rep 2017 Oct 4;2017. Epub 2017 Oct 4.
    Department of Psychiatry, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
    We report a case in a young man who developed acute, persistent and painful tongue protrusion followed by swelling for more than 24 hours. He had relapse symptoms of schizophrenia and had recently received a single dose of parenteral haloperidol to manage his agitation. His record showed history of similar event and he has been taking atypical antipsychotic for maintenance. Read More

    Factor XII-Driven Inflammatory Reactions with Implications for Anaphylaxis.
    Front Immunol 2017 15;8:1115. Epub 2017 Sep 15.
    Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Anaphylaxis is a life-threatening allergic reaction. It is triggered by the release of pro-inflammatory cytokines and mediators from mast cells and basophils in response to immunologic or non-immunologic mechanisms. Mediators that are released upon mast cell activation include the highly sulfated polysaccharide and inorganic polymer heparin and polyphosphate (polyP), respectively. Read More

    [Giardia duodenalis and its involvement in skin diseases].
    Ann Dermatol Venereol 2017 Nov 29;144(11):676-684. Epub 2017 Sep 29.
    Fondation Cheikh Khalifa Mohammed VI, Casablanca, Maroc; Faculté de médecine et de pharmacie, université Hassan II, Casablanca, Maroc.
    Backgound: Over the last thirty years, the scientific community has become increasingly interested in the intestinal flora, whether commensal or pathogenic, and its impact on other organs. In dermatology, the correlation between intestinal microbial agents and cutaneous lesions is well established. Giardia duodenalis, an intestinal parasite, has been particularly widely studied. Read More

    [Neprilysin inhibition and chronic kidney disease].
    G Ital Nefrol 2017 Sep 28;34(5):102-112. Epub 2017 Sep 28.
    Dipartimento delle insufficienze d'organo e dei trapianti, Policlinico S.Orsola-Malpighi, Bologna, Italy.
    Patients with chronic kidney disease (CKD) have a higher incidence of cardiovascular (acute and chronic) events, which in turn have an increased risk of progression to end-stage renal disease (ESRD) Inhibition of neprilysin, in addition to offering a new therapeutic target in patients with heart failure, could represent a potential improvement strategy in cardiovascular and renal outcome of patients with CKD. Inhibition of neprilysin by inhibiting the breakdown of natriuretic peptides, increases their bioavailability resulting in an increase in diuresis and sodium excretion and, in addition to exerting an inhibition of the renin-angiotensin-aldosterone (RAAS) system. Inhibition of RAAS, in turn, generates a series of counter-regulations that can balance the adverse effects present in CKD and heart failure (HF). Read More

    Inclusion of the Acute Care Surgeon in the Difficult Airway Protocol: A Nine-Year Experience.
    Am Surg 2017 Sep;83(9):943-946
    An emergency surgical airway is a lifesaving intervention required in the event of airway loss or respiratory failure when conventional endotracheal intubation cannot be performed. The Acute Care Surgery/Trauma Service is a critical component in the angioedema/difficult airway protocol at our institution. We conducted a retrospective review (2007-2016) to analyze the role our service has in managing patients requiring an emergency surgical airway. Read More

    Episodic angioedema associated with eosinophilia.
    An Bras Dermatol 2017 Jul-Aug;92(4):534-536
    Department of Dermatology, Jinling Hospital affiliated to Nanjing University School of Medicine - Jiangsu, China.
    We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years. During the episode, her white blood cell count increased to 47.7×109/L with 89. Read More

    An ABC of the Warning Signs of Hereditary Angioedema.
    Int Arch Allergy Immunol 2017 27;174(1):1-6. Epub 2017 Sep 27.
    Faculdade de Medicina ABC, Santo Andre, Brazil.
    Hereditary angioedema (HAE) with C1 inhibitor deficiency is a genetic disorder that clinically manifests with attacks of angioedema in the subcutaneous and submucosal tissues, mainly in the extremities, abdomen, and upper airway. During attacks, vascular permeability is increased due to increased bradykinin (BK). This means that special therapies are needed for attacks that do not respond to traditional antiallergic therapies involving antihistamines, corticosteroids, and epinephrine. Read More

    Angioedema without urticaria caused by oral acitretin.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 09;26(3):67-68
    Department of Dermatology, University of Patras, Rio-Patras,Greece.
    The efficacy of oral acitretin in the systemic treatment of severe and recalcitrant dermatoses has been established in a large number of clinical trials. Its mucocutaneous and ocular adverse reactions are common or relatively common, whereas systemic side effects are either uncommon or rare and include teratogenesis, hyperlipidemia, hepatotoxicity, intracranial hypertension, myopathy, and peripheral neuropathy. Angioedema is a term used to describe an acute, solitary or multiple, circumscribed, and non-pitting mucocutaneous swelling that affects the dermis and the subcutaneous tissue, lasts 24 to 72 hours, and may become potentially life-threatening when the pharynx and/or the larynx are involved. Read More

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