7,694 results match your criteria Angioedema


Angioedema is an unfavorable factor for the response to omalizumab in chronic spontaneous urticaria: a retrospective study.

Dermatol Ther 2018 Sep 20:e12752. Epub 2018 Sep 20.

Mustafa Kemal University, Faculty of Medicine, Department of Dermatology, Hatay, Turkey.

Antihistamines are the first-line treatment option for chronic urticaria. In recent years, omalizumab, an anti-immunoglobulin-E humanized monoclonal antibody, has been used in patients with recalcitrant disease. This study aimed to retrospectively evaluate the efficacy and safety of omalizumab and determine whether there was a difference between complete and partial responses to omalizumab with respect to age, gender, disease duration and coexistence of angioedema. Read More

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September 2018

Risk factors for renal involvement and severe kidney disease in 2731 Chinese children with Henoch-Schönlein purpura: A retrospective study.

Medicine (Baltimore) 2018 Sep;97(38):e12520

Department of Pediatrics.

To identify the risk factors for developing renal involvement and severe kidney disease in Chinese childhood Henoch-Schönlein purpura (HSP) patients.This was a retrospective study of 2731 children with HSP diagnosed between 2012 and 2015. We analyzed their demographic data, clinical manifestations, and laboratory tests retrospectively. Read More

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September 2018

[The ulm emergency algorithm for the acute treatment of drug-induced, bradykinin-mediated angioedema].

Med Klin Intensivmed Notfmed 2018 Sep 19. Epub 2018 Sep 19.

Klinik für Hals‑, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm, Frauensteige 12, 89075, Ulm, Deutschland.

Background: Bradykinin-mediated, drug-induced edema like ACE-inhibitor-induced angioedema (ACEi AE) is almost exclusively located in the head and neck region and is potentially life threatening. To date, there are no guidelines or officially-approved treatments available for this pathology.

Objectives: We sought to provide a structured therapeutic algorithm for the acute treatment of drug-induced bradykinin-mediated angioedema. Read More

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September 2018

Allergic reactions in oral and perioral diseases-what do allergy skin test results show?

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Aug 18. Epub 2018 Aug 18.

Department of Dermatovenereology, University Hospital Center Sestre milosrdnice, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Objective: The aim of this study was to examine potential allergic reactions to different materials in oral and perioral diseases.

Study Design: The study included 230 consenting subjects in total-180 patients with oral and perioral diseases (30 patients each in the following groups: angioedema, oral lichenoid reactions [OLRs], burning mouth syndrome [BMS], gingivostomatitis, cheilitis, and perioral dermatitis) and 50 healthy controls. Comprehensive diagnostic workups were performed prior to patch testing with standard series allergens and with specific dental materials and skin prick testing (SPT) for food, preservatives and additives, and inhalants. Read More

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Heterogeneous predisposing factors and etiology in uvula edema patients.

J Investig Allergol Clin Immunol 2018 Sep 17. Epub 2018 Sep 17.

Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias, Departamento de Medicina y Especialidades Médicas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, Alcalá de Henares (Madrid), Spain.

Background And Objective: Edema of the uvula (EU) may appear in isolation or in association with other associated clinical manifestations such as urticaria, angioedema or anaphylaxis. EU may lead to upper airway obstruction, provoking obstructive respiratory distress and asphyxia. Objective: We sought to investigate the etiology of, and predisposing factors for, EU in a large population of patients referred to an outpatient clinic. Read More

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September 2018

Angioedema and emergency medicine: From pathophysiology to diagnosis and treatment.

Eur J Intern Med 2018 Sep 13. Epub 2018 Sep 13.

Medicina Interna, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda, Milano, Italy. Electronic address:

Angioedema is a self-limiting edema of the subcutaneous or submucosal tissues due to localised increase of microvascular permeability whose mediator may be histamine or bradykinin. Patients present to emergency department when angioedema involves oral cavity and larynx (life-threatening conditions) or gut (mimicking an acute abdomen). After initial evaluation of consciousness and vital signs to manage breathing and to support circulation if necessary, a simple approach can be applied for a correct diagnosis and treatment. Read More

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September 2018
2 Reads

Select hyperacute complications of ischemic stroke: cerebral edema, hemorrhagic transformation, and orolingual angioedema secondary to intravenous altepase.

Expert Rev Neurother 2018 Sep 14. Epub 2018 Sep 14.

a Department of Neurology , Stritch Medical Center, Loyola University Medical Center , Maywood , Illinois.

Introduction: Remarkable advances have occurred in the management of acute ischemic stroke especially in regards to reperfusion treatments. With advances in reperfusion treatments come the risk of complications associated with these treatments. Areas covered: The paper focuses on three acute complications that can occur in the setting of acute ischemic stroke: cerebral edema, hemorrhagic transformation, and orolingual angioedema following administration of alteplase, a recombinant tissue plasminogen activator. Read More

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September 2018

Managing chronic spontaneous urticaria (hives) in primary care.

Authors:
Emily Carne

Nurs Stand 2018 Sep 13. Epub 2018 Sep 13.

Immunology and allergy, University Hospital of Wales, Cardiff, Wales.

Chronic spontaneous urticaria is characterised by the spontaneous appearance of hives or wheals, and/or angioedema, lasting for at least six weeks. The condition may be associated with significant physical and emotional burden for patients. Nurses have an important role in the differential diagnosis of chronic spontaneous urticaria, assessing patients' quality of life, providing advice on non-pharmacological measures, monitoring the patient's response to treatment, and referring the patient for specialist care, where appropriate. Read More

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September 2018
1 Read

Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin.

Cureus 2018 Jul 11;10(7):e2965. Epub 2018 Jul 11.

Internal Medicine, Icahn School of Medicine at Mount Sinai/Queens Hospital Center, New York, USA.

Hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins) are first-line medication for lowering serum cholesterol levels in the prevention of cardiovascular disease. Angioedema is the swelling of mucosa and submucosal tissue. There are no published cases of drug-induced angioedema involving rosuvastatin. Read More

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ISMP Adverse Drug Reactions: Adalimumab-Induced Aseptic Meningitis Pill Desiccant -Induced Acute Hypoxic Respiratory Failure Rivastigmine Patch -Induced Angioedema Acute Liver Failure Due to Etodolac Severe Cognitive Impairment Due to High Free Valproic Acid Levels.

Hosp Pharm 2018 Oct 18;53(5):292-295. Epub 2018 Aug 18.

Temple University School of Pharmacy, Philadelphia, PA, USA.

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of revention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA) MedWatch program (800-ßDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with ur readers. E-mail Dr. Read More

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October 2018
1 Read

Hereditary Angioedema from 1888 to 2018 -Progress and Problems.

Intern Med 2018 Sep 12. Epub 2018 Sep 12.

Department of Internal Medicine, Kyushu University Beppu Hospital, Japan.

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September 2018
1 Read

The role of skin testing and extended antibiotic courses in assessment of children with penicillin allergy: An Australian experience.

J Paediatr Child Health 2018 Sep 13. Epub 2018 Sep 13.

Department of Paediatric Immunology, Perth Children's Hospital, Perth, Western Australia, Australia.

Aim: To determine if skin testing (ST) in addition to extended oral provocation challenge (OPC) is necessary for beta-lactam allergy verification in an Australian paediatric population.

Methods: This was a retrospective study (176 children) that undertook assessments for beta-lactam allergy from 2006 to 2015 at a tertiary paediatric hospital. Patients either underwent direct OPC without ST or ST plus challenge if ST was negative. Read More

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September 2018

CT Findings of Acute Small-Bowel Entities.

Radiographics 2018 Sep-Oct;38(5):1352-1369

From the Department of Radiology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259 (M.D.S., C.O.M.); Department of Radiology, University of Wisconsin Hospital, Madison, Wis (M.G.L.); Division of Diagnostic Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Mo (S.B., V.M.M.); Stony Brook University School of Medicine, Stony Brook, NY (M.H.K.); and Department of Radiology, NYU Winthrop Hospital, Mineola, NY (D.S.K.).

Although a broad spectrum of entities can induce acute pathologic changes in the small bowel, there are relatively few imaging features that are characteristic of a specific diagnosis on the basis of CT findings. Specific clinical information, including time course and onset of disease, patient risk factors, and any recent pharmacologic or radiation therapy, is often instrumental in refining the differential diagnosis. A wide spectrum of disorders is reviewed in this article; however, given the breadth of disorders associated with the small bowel, neoplastic and infectious conditions affecting the small bowel that can manifest acutely are not specifically discussed. Read More

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September 2018
5 Reads

Acute-phase response and its biomarkers in acute and chronic urticaria.

Postepy Dermatol Alergol 2018 Aug 21;35(4):400-407. Epub 2018 Aug 21.

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: Since urticaria is a persisting inflammatory disease it is important to establish the prognostic factors for the duration and severity of the disease.

Aim: To evaluate serum concentrations of selected acute-phase proteins (APP) in patients with various forms of urticaria as compared to healthy volunteers and also to analyze these concentrations in different types of urticaria. Additionally, to evaluate the correlation between serum levels of selected APP and disease activity. Read More

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August 2018
3 Reads

Acute diffuse and transient thyroid swelling after intravenous thrombolysis for acute ischemic stroke: A case report.

Medicine (Baltimore) 2018 Sep;97(36):e12149

Department of Ultrasound, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Rationale: Intravenous thrombolysis is the primary therapy for acute ischemic stroke (AIS), but it has some complications, including symptomatic intracranial hemorrhage, orolingual angioedema, and extracranial bleeding. However, thyroid disorders associated with thrombolysis are very rare.

Patient Concerns: A 56-year-old man developed acute pain and neck swelling after thrombolysis with recombinant tissue plasminogen activator. Read More

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September 2018
1 Read

[Subcutaneous Emphysema and Pneumomediastinum During a Tooth Extraction].

Acta Med Port 2018 Aug 31;31(7-8):435-439. Epub 2018 Aug 31.

Serviço de Medicina Interna III. Centro Hospitalar Lisboa Norte. Lisboa. Portugal.

Subcutaneous emphysema is a possible but rare complication after dental procedures. The condition should be distinguished from other situations, such as hematoma, allergic reaction or angioedema, and infection. We describe the case of a 20-year-old puerperal woman, with multiple dental caries, who developed cervicofacial subcutaneous emphysema complicated by pneumomediastinum, following an incomplete extraction of the lower right second molar. Read More

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August 2018
1 Read

Mammalian meat allergy.

Int J Dermatol 2018 Sep 4. Epub 2018 Sep 4.

University of New South Wales, Kensington, NSW, Australia.

Mammalian meat allergy is an allergic reaction mediated by IgE antibodies directed against the mammalian oligosaccharide epitope galactose-α-1,3-galactose. Clinically, it is characterized by a range of symptoms including urticaria, angioedema, gastroenteritis, and anaphylaxis hours following ingestion of red meat. It is an emergent allergy in tick endemic areas across the world. Read More

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September 2018
1 Read

[Frey's syndrome in the allergology consultation].

Rev Alerg Mex 2018 Jul-Sep;65(3):219-223

Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Medellín, Colombia.

Background: Frey's syndrome is a group of symptoms that include unilateral sweating with malar region and external ear reddening after eating or drinking some food. It is a lesion of the auriculotemporal nerve that is secondary to surgery, parotid gland infection or facial trauma.

Clinical Cases: Three children between 4 and two and a half years of age: two girls and one boy. Read More

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September 2018
3 Reads

[Quality of life in chronic urticaria and its relationship with economic impact and disease control in patients attended to at the University Hospital of Monterrey, Mexico].

Rev Alerg Mex 2018 Jul-Sep;65(3):170-178

Universidad Autónoma de Nuevo León, Hospital Universitario Dr. José Eleuterio González, Centro Regional de Alergia e Inmunología Clínica, Monterrey, Nuevo León, México.

Background: Chronic urticaria (CU) manifests itself with hives and sometimes angioedema. Physical and social discomfort worsens patient quality of life. CU has an important impact on patients' economy. Read More

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September 2018
5 Reads

Management of patients with hereditary angioedema in Germany: comparison to other countries in the Icatibant Outcome Survey.

J Eur Acad Dermatol Venereol 2018 Sep 3. Epub 2018 Sep 3.

Department of Dermatology and Allergy, Allergy Center Charité, Charité -Universitätsmedizin Berlin, Berlin, Germany.

Background: The Icatibant Outcome Survey (IOS; NCT01034969) is a Shire-sponsored, international, observational study monitoring the safety and effectiveness of icatibant, a bradykinin B2 receptor antagonist approved for the acute treatment of adults with hereditary angioedema with C1 inhibitor deficiency (HAE-C1-INH).

Objective: To report IOS data comparing demographic and icatibant-treatment outcomes in patients with HAE-C1-INH from Germany to HAE-C1-INH patients from 11 other IOS countries.

Methods: A descriptive, retrospective, comparative analysis of data from 685 IOS patients with HAE-C1-INH from seven centres in Germany (n = 93) vs. Read More

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September 2018
2 Reads

Pediatricians diagnosed few patients with childhood-presented hereditary angioedema: Icatibant Outcome Survey findings.

J Allergy Clin Immunol Pract 2018 Aug 28. Epub 2018 Aug 28.

Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

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August 2018
4 Reads

THE JEREMIAH METZGER LECTURE NOVEL THERAPEUTIC STRATEGIES OF ALLERGIC AND IMMUNOLOGIC DISORDERS.

Trans Am Clin Climatol Assoc 2018 ;129:250-265

NEW YORK, NEW YORK.

Advances in understanding the immunological basis and mechanisms underlying allergic and immunologic disorders have led to effective but costly long-term and repetitive biologic therapies. Gene therapy is a rapidly advancing technology, in which a single administration of an adeno-associated virus encoding the therapeutic protein or monoclonal antibody may provide effective long-term therapy for allergic and immunologic disorders. In this review, we summarize the recent studies from our laboratory developing gene therapy strategies to treat hereditary angioedema and peanut allergy. Read More

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January 2018
2 Reads

Seasonality of the hospitalizations at a dermatologic ward (2007-2017).

An Bras Dermatol 2018 Sep-Oct;93(5):755-758

Department of Dermatology and Radiotherapy, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu (SP), Brazil.

There is little data in the literature concerning dermatologic admissions. Several diseases are seasonal in incidence and clinical worsening. We performed a survey of hospitalizations in the dermatology ward of a public hospital (April/2007 to May/2017). Read More

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May 2017
3 Reads

Camel's milk allergy.

Allergy Asthma Proc 2018 Sep;39(5):384-388

Departments of Biostatistics and Medical Informatics, Cerrahpaşa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Introduction: Camel's milk is a safe and therapeutic nutrient. Camel's milk allergy is almost unknown.

Objective: To identify the clinical and laboratory features of camel's milk allergy. Read More

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September 2018
2 Reads

Hereditary angioedema revisited.

Allergy Asthma Proc 2018 Sep;39(5):329-331

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September 2018
7 Reads

Allergy and Asthma: Food Allergies.

Authors:
Raj Mehta

FP Essent 2018 Sep;472:16-19

Florida Hospital Family Medicine Residency, 133 Benmore Drive, Winter Park, FL 32792.

Food allergies are immune-mediated allergic adverse reactions that occur after exposure to specific foods. The most commonly recognized food allergies are immunoglobulin E (IgE)-mediated reactions (eg, urticaria, angioedema, anaphylaxis) that result from exposure to milk, egg, peanut, tree nuts, shellfish, fish, wheat, or soy. However, other foods can cause food allergies. Read More

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September 2018
4 Reads

Good vibrations: itch induction by whole body vibration exercise without the need of a pruritogen.

Exp Dermatol 2018 Aug 27. Epub 2018 Aug 27.

Clinic of Orthopaedics and Traumatology, University Hospital Basel, Basel, Switzerland.

Mechanically induced itch is an important cofactor in many patients with chronic itch. However, studying mechanical itch in a controlled environment is challenging because it is difficult to evoke. We investigated the use of whole body vibration exercise (WBV) exercise, a training method used for musculoskeletal rehabilitation, to experimentally evoke mechanical itch. Read More

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August 2018
2 Reads

A Case Report of Unilateral Orolingual Angioedema Secondary to Alteplase Administration.

Cureus 2018 Jun 23;10(6):e2869. Epub 2018 Jun 23.

Emergency Department, The University of Chicago Medicine, Chicago, USA.

Emergency physicians should be aware of adverse drug reactions prior to administering medication. Alteplase, or tissue plasminogen activator (tPA), is a common medication in the emergency department, whether it is being used for a stroke or pulmonary embolus. Angioedema can be caused by almost any medication. Read More

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June 2018
1 Read

Recurrent Acute Abdomen as the Main Manifestation of Hereditary Angioedema.

Intern Med 2018 Aug 24. Epub 2018 Aug 24.

Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Japan.

A diagnosis of hereditary angioedema is usually made with recurrent episodes of swelling of the subcutaneous tissue with a family history. We herein report a case in which recurrent acute abdomen was the main manifestation of hereditary angioedema. A 45-year-old womon presented with a 10-year history of recurrent severe abdominal pain. Read More

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August 2018
1 Read

The Role of Allergy in Phonation.

J Voice 2018 Aug 22. Epub 2018 Aug 22.

Athens Speech Language and Swallowing Institute, Athens, Greece.

Background: Allergies are among the most common chronic conditions worldwide affecting 10%-30% of adult individuals and 40% of children. Phonation can be affected by different allergic conditions in various ways. The role of allergy in phonation has been under-researched and poorly understood and the respective literature is poor. Read More

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August 2018
3 Reads

Assessment of circulating FCεRIa in Chronic Spontaneous Urticaria patients and its correlation with clinical and immunological variables.

Immunobiology 2018 Aug 20. Epub 2018 Aug 20.

Department of Clinical Pathology, Faculty of Human Medicine, Zagazig University, Egypt.

Chronic spontaneous urticaria (CSU) is a chronic type characterized by episodes of wheals with or without angioedema. Autoantibody against the alpha subunit of Fc epsilon receptor (FcεRIa) was detected in CSU patients' sera. The study aims to evaluate the clinical utility of skin tests in CSU patients. Read More

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August 2018
1 Read

Sirolimus-induced severe small bowel angioedema: A case report.

Medicine (Baltimore) 2018 Aug;97(34):e12029

Department of Pharmacy.

Rationale: Drug-induced angioedema has been reported as an adverse effect of many different drugs. But small bowel angioedema associated with sirolimus (SRL) used was barely understood. It must be necessary to report a case suffering from small bowel angioedema with detailed discussion and literature review. Read More

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August 2018
3 Reads
5.72 Impact Factor

Omalizumab for Idiopathic Nonhistaminergic Angioedema: Evidence for Efficacy in 2 Patients.

Case Reports Immunol 2018 22;2018:8067610. Epub 2018 Jul 22.

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Presently, there is inconclusive evidence regarding the most effective treatment for idiopathic nonhistaminergic acquired angioedema (InH-AAE). Omalizumab may, however, prove to be a promising option. This case report describes two patients who presented with recurrent angioedema attacks, which was refractory to antihistamine therapy. Read More

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July 2018
1 Read

Economic burden limiting proper healthcare delivery, management, and improvement of patient outcomes.

Am J Manag Care 2018 Aug;24(14 Suppl):S308-S313

Director of Pharmacy Revenue & Supply, Atrius Health, Watertown, MA. Email:

Although several new therapies to both treat acute hereditary angioedema (HAE) attacks and provide prophylaxis for patients with recurrent episodes have been introduced in the past several years, HAE remains a disease with a substantial physical, psychosocial, and economic burden to both affected patients and society in general. Not all treatments work for all patients, and research is ongoing to improve HAE diagnosis and selection of therapy for individual patients to optimize outcomes. But the disease has a significant economic impact with high direct and indirect costs, and high charges related to the new therapies developed for patients to reduce symptoms and attack recurrence. Read More

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August 2018
1 Read

Current and emerging therapies to prevent hereditary angioedema attacks.

Authors:
William R Lumry

Am J Manag Care 2018 Aug;24(14 Suppl):S299-S307

Clinical Professor of Internal Medicine, Allergy/Immunology Division, University of Texas Southwestern Medical School, private practice, Dallas, TX. Email:

Hereditary angioedema (HAE) is a rare genetic disease defined by recurrent attacks of edema, causing a substantial burden for patients, with morbidity, mortality, and reduced quality of life. This burden is increased by delayed diagnosis, inappropriate treatment, and suboptimal follow-up and patient education. Several novel therapeutics have recently been approved or are currently under evaluation for prevention of HAE attacks. Read More

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August 2018
5 Reads

Severity of hereditary angioedema, prevalence, and diagnostic considerations.

Am J Manag Care 2018 Aug;24(14 Suppl):S292-S298

Professor of Clinical Medicine, University of Cincinnati College of Medicine, Department of Internal Medicine; Division of Immunology, Allergy Section, Cincinnati, OH. Email:

Hereditary angioedema (HAE) is a rare disorder, characterized by intermittent attacks of swelling in any part of the body, without the presence of hives. This lifelong disease typically presents in the first 2 decades of life, and is commonly associated with a deficiency in functional C1 esterase inhibitor (C1-INH) activity. C1-INH levels may be decreased or normal, with an accompanied decrease in functionality, depending on the type of HAE present. Read More

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August 2018
7 Reads

Repeated attacks of type III hereditary angioedema with factor XII mutation during pregnancy.

Int J Obstet Anesth 2018 Aug 2. Epub 2018 Aug 2.

Anesthesiology Department, Trousseau Hospital, Paris, France. Electronic address:

In type III hereditary angioedema (HAE type III), the phenotype is the same as type I and type II disease, but the level and function of C1-esterase inhibitor (C1-INH) is normal. Hereditary angioedema type III has been described as an oestrogen-sensitive form because it can be triggered or aggravated by exposure to high oestrogen levels as seen during pregnancy, especially when associated with Factor XII mutation. This case report describes the evolution and management of repeated angioedema attacks during pregnancy in a woman with HAE, with normal levels and function of C1-INH (type III); and a mis-sense mutation of factor XII. Read More

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August 2018
6 Reads

Hereditary angioedema: the plasma contact system out of control: reply.

J Thromb Haemost 2018 Aug 21. Epub 2018 Aug 21.

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

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August 2018
4 Reads

Hereditary angioedema: the plasma contact system out of control: comment.

Authors:
S Loffredo G Marone

J Thromb Haemost 2018 Aug 21. Epub 2018 Aug 21.

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.

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August 2018
1 Read

Real-world outcomes in hereditary angioedema: first experience from the Icatibant Outcome Survey in the United Kingdom.

Allergy Asthma Clin Immunol 2018 6;14:28. Epub 2018 Aug 6.

Department of Immunology, Central Manchester University Hospital NHS Foundation Trust, Manchester, UK.

Background: Hereditary angioedema (HAE) is a potentially life-threatening, bradykinin-mediated disease, often misdiagnosed and under-treated, with long diagnostic delays. There are limited real-world data on best-practice management of HAE in the UK.

Objectives: To characterize the clinical profile, management and outcomes of patients with HAE type I and II from three specialist centres in the UK using data from the Icatibant Outcome Survey (IOS; Shire, Zug, Switzerland), an international observational study monitoring safety and effectiveness of icatibant, a selective bradykinin B2 receptor antagonist. Read More

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August 2018
4 Reads

Managing Clopidogrel Hypersensitivity without Interrupting Therapy: The Toronto Approach.

Authors:
Asim N Cheema

Curr Vasc Pharmacol 2018 Aug 19. Epub 2018 Aug 19.

Terrence Donnelly Heart Center, St. Michael's Hospital, Toronto, Ontario. Canada.

Clopidogrel remains a widely used antiplatelet agent for patients with established or high risk of atherothrombotic disease, particularly those treated with coronary, carotid or peripheral endovascular stenting. Clopidogrel hypersensitivity is an uncommon but well established adverse drug reaction presenting a challenge for patient management. The clinical presentation ranges from focal or diffuse cutaneous manifestations in most patients to angioedema in some and a systemic immune response in rare cases. Read More

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August 2018
1 Read

A hereditary angioedema screening on an index case: Turkey.

Asian Pac J Allergy Immunol 2018 Aug 13. Epub 2018 Aug 13.

Department of Pediatric Neurology, KahramanmarasSutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey.

Background: Hereditary angioedema (HAE) is characterised by recurrent episodes of angioedema and can be fatal.

Objective: The present study aimed to screen HAE.

Methods: A total of 60 individuals were screened. Read More

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August 2018
8 Reads

Subcutaneous C1-esterase inhibitor to prevent hereditary angioedema attacks: Safety findings from the COMPACT trial.

Allergy Asthma Proc 2018 Sep 14;39(5):365-370. Epub 2018 Aug 14.

CSL Behring, King of Prussia, Pennsylvania.

Background: The first subcutaneous (SC) C1-esterase inhibitor concentrate (C1-INH) was approved by the U.S. Food and Drug Administration in June 2017 as routine prophylaxis to prevent hereditary angioedema attacks in adolescents and adults at a dose of 60 IU/kg twice weekly based on the phase III Clinical Study for Optimal Management of Preventing Angioedema With Low-volume Subcutaneous C1-Inhibitor Replacement Therapy (COMPACT) trial. Read More

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September 2018
2 Reads

Novel low-abundance allergens from mango via combinatorial peptide libraries treatment: A proteomics study.

Food Chem 2018 Dec 27;269:652-660. Epub 2018 Jun 27.

Proteomics Unit, Quadram Institute Bioscience, Norwich Research Park, NR4 7UA England, United Kingdom; Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133 Milano, Italy. Electronic address:

Mango allergy is a rare condition, which may cause severe hypersensitivity reactions, such as anaphylaxis, angioedema, asthma and contact dermatitis. By exploiting the combinatorial peptide ligand library (CPLL) technology, mango proteomes have been extracted and the presence of traces of allergens assessed via Western blot analysis two-dimensional maps. Upon reactive spot elution and mass spectrometry analyses, four major mango allergens could be identified for the first time and shown to be in common with three of the five known banana species. Read More

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December 2018
1 Read

A 69-year-old woman with periodic fever, facial swelling, and neck pain.

Allergy Asthma Proc 2018 Jul;39(4):322-325

We presented a case of a 69-year-old woman who experienced monthly episodes of facial swelling and nonpruritic, erythematous rash on her face, accompanied by high fever, nausea, headache, and neck pain over 1 year. Her symptoms started with myalgia, arthralgia, fever and neck stiffness, and headache, and then angioedema occurred, which was painful to touch. She underwent multiple iatrogenic diagnostic and therapeutic procedures that did not lead to the correct diagnosis. Read More

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July 2018
2 Reads

Polymorphisms in CEP68 gene associated with risk of immediate selective reactions to non-steroidal anti-inflammatory drugs.

Pharmacogenomics J 2018 Aug 10. Epub 2018 Aug 10.

Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.

Non-steroidal anti-inflammatory drugs (NSAIDs) are the main triggers of drug hypersensitivity reactions. Such reactions can be pharmacologically or immunologically mediated, but in both cases individual susceptibility can be influenced by genetic factors. Polymorphisms in centrosomal protein of 68 kDa (CEP68) have been associated with pharmacologically mediated NSAIDs reactions. Read More

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August 2018
7 Reads

Incidence of orolingual angioedema after intravenous thrombolysis for stroke.

Neurol Sci 2018 Aug 6. Epub 2018 Aug 6.

USC Neurologia, ASST Papa Giovanni XXIII, Piazza OMS 1, 24127, Bergamo, Italy.

Introduction: Orolingual angioedema (OA) is a known adverse effect of intravenous (i.v.) alteplase. Read More

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August 2018
4 Reads

Intramuscular Epinephrine-Induced Transient ST-Elevation Myocardial Infarction.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618785651. Epub 2018 Jul 6.

Interfaith Medical Center, Brooklyn, NY, USA.

Myocardial infarction in the setting of anaphylaxis may result from the anaphylaxis itself or from the epinephrine used to treat the anaphylaxis. While cases of myocardial infarction due to large doses of intravenous epinephrine have previously been reported, myocardial infarction after therapeutic doses of intramuscular epinephrine is rarely reported. A 23-year-old male presented with sudden onset of difficulty in swallowing and speech after eating takeout food. Read More

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July 2018
1 Read

Secreted Phospholipases A in Hereditary Angioedema With C1-Inhibitor Deficiency.

Front Immunol 2018 23;9:1721. Epub 2018 Jul 23.

Department of Translational Medical Sciences, Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, WAO Center of Excellence, Naples, Italy.

Background: Hereditary angioedema (HAE) caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein (C1-INH-HAE) is a disabling, potentially fatal condition characterized by recurrent episodes of swelling. We have recently found that patients with C1-INH-HAE have increased plasma levels of vascular endothelial growth factors and angiopoietins (Angs), which have been associated with vascular permeability in several diseases. Among these and other factors, blood endothelial cells and vascular permeability can be modulated by extracellular or secreted phospholipases A (sPLAs). Read More

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July 2018
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Fatal outcome of late-onset angiotensin-converting enzyme inhibitor induced angioedema: A case report.

Medicine (Baltimore) 2018 Aug;97(31):e11695

Institute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Rationale: Angiotensin-converting enzyme (ACE) inhibitors are one of the most used medication among patients with arterial hypertension. In most cases, ACE inhibitors caused side effects are mild; however, from 0.1% to 0. Read More

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August 2018
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