7,618 results match your criteria Angioedema


On the pathogenicity of the plasminogen K330E mutation for hereditary angioedema.

Allergy 2018 Aug;73(8):1751-1753

Department of Medical Psychology and Medical Sociology, Johannes Gutenberg University, Mainz, Germany.

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Hymenoptera Anaphylaxis as a Clonal Mast Cell Disorder.

Immunol Allergy Clin North Am 2018 Aug 9;38(3):455-468. Epub 2018 Jun 9.

Multidisciplinary Outpatients Clinic for Mastocytosis (GISM), Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Stefani 1, Verona 37126, Italy; Department of Medicine, Section of Hematology, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale L.A. Scuro 10, Verona 37134, Italy.

Up to 7% of adult patients with Hymenoptera venom allergy may suffer from a clonal mast cell disease. Patients with clonal mast cell disease and Hymenoptera venom anaphylaxis are commonly males, without skin lesions, and anaphylaxis is characterized by hypotension and syncope in the absence of urticaria and angioedema. A normal value of tryptase does not exclude a mastocytosis. Read More

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Emotional processes and stress in children affected by hereditary angioedema with C1-inhibitor deficiency: a multicenter, prospective study.

Orphanet J Rare Dis 2018 Jul 13;13(1):115. Epub 2018 Jul 13.

Department of Humanities, University Federico II, via Porta di Massa 1, 80133, Naples, Italy.

Background: Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is characterized by recurrent edema of unpredictable frequency and severity. Stress, anxiety, and low mood are among the triggering factors most frequently reported. Impaired regulation and processing of emotions, also known as alexithymia, may influence outcomes. Read More

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Clinical experiences and case review of angiotensin II receptor blocker-related angioedema in Korea.

Basic Clin Pharmacol Toxicol 2018 Jul 13. Epub 2018 Jul 13.

Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Although angiotensin-converting enzyme inhibitor-related angioedema is well known, angiotensin II receptor blocker (ARB)-related angioedema has not been extensively studied because of its lower incidence. Therefore, ARB-related angioedema is likely to be overlooked in the clinical setting. We analysed the medical records of adults who had been prescribed ARB and diagnosed with angioedema between 2009 and 2015. Read More

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July 2018
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[Successful oral desensitization to levothyroxine. Report of one case].

Rev Med Chil 2018 Mar;146(3):394-398

Servicio Alergología, Hospital Universitario Ramón y Cajal, Madrid, España.

We report a 39-year-old female who underwent a total thyroidectomy as treatment for a thyroid papillary cancer. She suffered several episodes of mild angioedema in lips and tongue, after using different commercial Levothyroxine formulations, with and without excipients. Given the need to use this drug, the patient was admitted in our hospital and we proceeded to desensitize her with oral Levothyroxine. Read More

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Population pharmacokinetics of subcutaneous C1-inhibitor for prevention of attacks in patients with hereditary angioedema.

Clin Exp Allergy 2018 Jul 12. Epub 2018 Jul 12.

CSL Limited, Parkville, Australia.

Background: Long-term prophylaxis with subcutaneous (SC) administration of a highly concentrated plasma-derived C1 esterase inhibitor (C1-INH) formulation was recently approved by the Food and Drug Administration for hereditary angioedema (HAE) attack prevention.

Objective: To characterize the population pharmacokinetics of C1-INH (SC) (HAEGARDA ; CSL Behring) in healthy volunteers and HAE patients, and assess the variability and influence of covariates on pharmacokinetics.

Methods: C1-INH functional activity data obtained after administration of various C1-INH (intravenous; IV) and C1-INH (SC) doses from one study in healthy volunteers (n=16) and two studies in subjects with HAE (n=108) were pooled to develop a population pharmacokinetic model (NONMEM v7. Read More

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July 2018
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A missense mutation of the plasminogen gene in hereditary angioedema with normal C1 inhibitor in Japan.

Allergy 2018 Jul 10. Epub 2018 Jul 10.

Center for Research, Education and Treatment of angioEdema, a specified Non-profit Corporation, Fukuoka, Japan.

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Diagnosing Meat Allergy After Tick Bite Without Delay.

J Am Board Fam Med 2018 Jul-Aug;31(4):650-652

From Jersey Shore University Medical Center, Neptune, NJ (ACK, MPC).

Galactose-α-1, 3 galactose (α-gal) is a carbohydrate found in mammalian meat. In 2007, it was implicated as a cause of severe hypersensitivity reactions when a study found elevated levels of antibodies directed against this oligosaccharide among patients treated with cetuximab, a monoclonal antibody that contained an α -gal epitope. The majority of these cases were reported in the Southeast United States in a distribution similar to that of Rocky Mountain spotted fever and ehrlichiosis, and that geographic association led researchers to the conclusion that a bite from the Lone Star tick can induce this antibody. Read More

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October 2017

Cross-reactivity pattern of a rare presentation of generalized delayed-type hypersensitivity to local anaesthetics.

Asian Pac J Allergy Immunol 2018 Jul 8. Epub 2018 Jul 8.

Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

A seven-year-old girl developed angioedema and a generalized, erythematous rash several hours after receiving lignocaine with adrenaline reproducible on provocative challenge, confirming the first known case of generalized delayed-type hypersensitivity to local anaesthetics with cross-reactivity to bupivacaine but not chloroprocaine. Read More

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Amlodipine-induced angioedema: An unusual complication of a common medication.

Allergy Rhinol (Providence) 2018 Jan-Dec;9:2152656718764139. Epub 2018 Apr 6.

Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts.

Hypersensitivity reactions to dihydropyridine calcium channel blockers (CCB) are exceedingly rare, although sporadic reports of isolated angioedema seem to be gradually increasing in frequency. We present a case of angioedema likely triggered by amlodipine. Read More

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The Eyes Have It: Eyelid Swelling and Rash in a 79-year-old Woman With Macular Degeneration.

Allergy Rhinol (Providence) 2018 Jan-Dec;9:2152656718763385. Epub 2018 May 1.

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.

Introduction: A 79-year-old woman with macular degeneration was referred to the Allergy/Immunology clinic for the evaluation of a potential allergy to anti-vascular endothelial growth factor (anti-VEGF) treatments. The patient developed urticaria and eyelid swelling immediately following a retinal injection of aflibercept, which she had previously tolerated. She previously had allergic reactions following ranibizumab and bevacizumab injections. Read More

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May 2018
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NSAID hypersensitivity - recommendations for diagnostic work up and patient management.

Authors:
Stefan Wöhrl

Allergo J Int 2018 25;27(4):114-121. Epub 2018 May 25.

Floridsdorf Allergy Center (FAZ), Pius-Parsch-Platz 1/3, 1210 Vienna, Austria.

Background: Adverse drug reactions (ADR) to analgesics (i.e., non-steroidal anti-inflammatory drug hypersensitivity, NSAID-HS) are one of the most common ADR, affecting approximately 1. Read More

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May 2018
5 Reads

Enalapril-Induced Angioedema: Two Case Reports in a Rural Health Facility in Kenya.

Cureus 2018 May 2;10(5):e2572. Epub 2018 May 2.

Department of Clinical Medicine, Nyakach County Hospital.

Tolerability, a good safety profile, affordability, and a preponderance to afford cardio-renal protection in patients with diabetes make enalapril one of the most commonly prescribed angiotensin-converting enzyme (ACE) inhibitors. However, there is low awareness of enalapril/ACE inhibitor-induced angioedema among medical personnel. This is because the diagnosis presents an ongoing challenge, particularly when the presentation is delayed following long-term therapy with ACE inhibitors. Read More

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May 2018
2 Reads

Angioedema Associated With Nebulized Recombinant Human DNase in a Preterm Infant: Case Report.

J Pediatr Pharmacol Ther 2018 May-Jun;23(3):219-222

Pulmonary atelectasis leads to difficulties in weaning of the neonates from mechanical ventilation. The management of persistent atelectasis in neonates constitutes a common challenge for physicians. Several reports suggested Recombinant human DNase (rhDNase) as a beneficial therapy for neonates with persistent atelectasis by reducing mucous viscosity. Read More

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[A Rare Cause of an Angioedema-Like Habitus].

Praxis (Bern 1994) 2018 Jul;107(14):773-776

1 Interdisziplinäre Notfallstation, Kantonsspital Olten.

A Rare Cause of an Angioedema-Like Habitus Abstract. We report about a 69-year-old patient arriving at the emergency room with suspected allergic reaction grade III due to a pronounced facial swelling, dyspnea and dizziness. However, the cause was a bilateral pneumothorax with massive soft-tissue emphysema. Read More

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July 2018
1 Read

Efficacy of C1Inhibitor concentrate in hereditary angioedema with C1Inhibitor deficiency: analysis in the French Cohort.

Ann Allergy Asthma Immunol 2018 Jun 28. Epub 2018 Jun 28.

Department of Internal Medicine, Grenoble University Hospital, Grenoble, France; National Reference Centre for Angioedema, CREAK, France.

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Canadian Physician Survey on the Medical Management of Hereditary Angioedema.

Ann Allergy Asthma Immunol 2018 Jun 26. Epub 2018 Jun 26.

Department of Medicine, Division of Clinical Immunology and Allergy, University of Toronto, Toronto, Ontario; Division of Allergy and Immunology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.

Background: Hereditary angioedema (HAE) is a rare disease that has significant morbidity and may be potentially fatal due to airway obstruction. Our study aimed to determine how Canadian physicians diagnose and treat HAE.

Objective: To determine practice patterns in physicians treating HAE. Read More

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June 2018
1 Read

The Incidence and Frequency of Various Causes of Angioedema in Emergency Medicine.

Acta Med Acad 2018 May;47(1):11-17

University of Zagreb, School of Medicine Zagreb, Zagreb, Croatia; Clinical Hospital Merkur, Department of Internal Medicine/Emergency Unit, Zagreb, Croatia.

Objective: Angioedema (AE) is a potentially life-threatening event. We investigated the etiology of AE, with the emphasis on bradykinininduced angioedema treatment in emergency medicine.

Methods: The retrospective study included 237 patients with AE, who were examined and treated in two hospitals (group A and B) in Croatia from 2009 to 2016. Read More

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May 2018
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Threshold-Stimulated Kallikrein Activity Distinguishes Bradykinin- From Histamine-Mediated Angioedema.

Clin Exp Allergy 2018 Jun 29. Epub 2018 Jun 29.

Division of Rheumatology, Allergy and Immunology, Dept. of Medicine, UC San Diego Dept of Medicine, UC San Diego, 9500 Gilman Dr , Mail Code # 0732, La Jolla, CA, 92037-0732.

Background: The lack of specific biomarkers makes the diagnosis of hereditary angioedema (HAE) with normal levels of C1-inhibitor (C1INH) protein (HAE-nl-C1INH) and idiopathic non-histaminergic angioedema (INHA) difficult. Confirming or excluding these diagnoses is a significant challenge for clinicians evaluating patients with angioedema.

Objective: To develop a reliable biomarker that would aid the diagnosis of HAE-nl-C1INH and INHA. Read More

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June 2018
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Prevalence of drugs as triggers of exacerbations in chronic urticaria.

J Investig Allergol Clin Immunol 2018 Jun 29. Epub 2018 Jun 29.

Group of Clinical and Experimental Allergy. IPS Universitaria, University of Antioquia, Medellin, Colombia.

Background And Objective: Many patients with chronic spontaneous urticaria (CSU) identify different drugs as triggers of their symptoms and often make restrictions without enough information. Objective: To estimate the clinical impact of the drugs most frequently reported as suspects of CSU exacerbations by patients.

Methods: All subjects were questioned about their clinical history of urticaria and drug reactions. Read More

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June 2018
3 Reads

Efficacy of recombinant human C1 esterase inhibitor across anatomic locations in acute hereditary angioedema attacks.

Allergy Asthma Proc 2018 Jun 28. Epub 2018 Jun 28.

>Background: Hereditary angioedema (HAE) may occur at or spread to multiple anatomic locations during an acute attack.Recombinant human C1 esterase inhibitor (rhC1-INH) is approved for treating acute HAE attacks.

Objective: To examine the time to the beginning of symptom relief with rhC1-INH by attack location. Read More

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June 2018
1 Read

Acquired angioedema in juvenile systemic lupus erythematosus: case-based review.

Rheumatol Int 2018 Aug 27;38(8):1577-1584. Epub 2018 Jun 27.

Department of Pediatric of Rheumatology, Pamukkale University School of Medicine, Pamukkale, Denizli, Turkey.

An acquired form of angioedema that is clinically similar but scarcer than the hereditary form may be caused, even more rarely, by the presence of an underlying autoimmune disease. We report a previously healthy 16-year-old girl with an acquired angioedema as a rare and initial presentation of systemic lupus erythematosus. The patient had no previous angioedema attack and no family history. Read More

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August 2018
1 Read

[Alpha-Gal-associated delayed red meat anaphylaxis as an occupational disease].

Hautarzt 2018 Jun 27. Epub 2018 Jun 27.

Forschungsgruppe Klinische und Molekulare Allergologie des Forschungszentrums Borstel, Airway Research Center North (ARCN), Mitglied des Deutschen Zentrums für Lungenforschung (DZL), Parkallee 35, 23845, Borstel, Deutschland.

In a 30-year-old chef with recurrent delayed angioedema history as well as the experimental detection of IgE antibodies against galactose-alpha-(1,3)-galactose (alpha-Gal) pointed to alpha-Gal as the causative agent. The diagnosis, therefore, was delayed anaphylaxis due to alpha-Gal. Because of the potential relationship to his profession, we submitted a dermatologist's report BK 5101 to the liability and insurance association, whereupon his contract of employment was terminated without notice. Read More

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June 2018
3 Reads

Unilateral orolingual angioedema after thrombolysis in a patient with cerebrovascular ischemia.

Intensive Care Med 2018 Jun 8. Epub 2018 Jun 8.

Department of Intensive Care Medicine, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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Assessing the impact of the new ICD-10-CM coding system on pharmacoepidemiologic studies-An application to the known association between angiotensin-converting enzyme inhibitors and angioedema.

Pharmacoepidemiol Drug Saf 2018 Jun 26. Epub 2018 Jun 26.

Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA.

Purpose: To replicate the well-established association between angiotensin-converting enzyme inhibitors versus beta blockers and angioedema in the International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) era.

Methods: We conducted a retrospective, inception cohort study in a large insurance database formatted to the Sentinel Common Data Model. We defined study periods spanning the ICD-9-CM era only, ICD-10-CM era only, and ICD-9-CM and ICD-10-CM era and conducted simple-forward mapping (SFM), simple-backward mapping (SBM), and forward-backward mapping (FBM) referencing the General Equivalence Mappings to translate the outcome (angioedema) and covariates from ICD-9-CM to ICD-10-CM. Read More

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June 2018
2 Reads

Early impact of the ICD-10-CM transition on selected health outcomes in 13 electronic health care databases in the United States.

Pharmacoepidemiol Drug Saf 2018 Jun 26. Epub 2018 Jun 26.

Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA.

Purpose: To describe the consistency in the frequency of 5 health outcomes across the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) and Tenth Revision, Clinical Modification (ICD-10-CM) eras in the US.

Methods: We examined the incidence of 3 acute conditions (acute myocardial infarction [AMI], angioedema, ischemic stroke) and the prevalence of 2 chronic conditions (diabetes, hypertension) during the final 5 years of the ICD-9-CM era (January 2010-September 2015) and the first 15 months of the ICD-10-CM era (October 2015-December 2016) in 13 electronic health care databases in the Sentinel System. For each health outcome reviewed during the ICD-10-CM era, we evaluated 4 definitions, including published algorithms derived from other countries, as well as simple-forward, simple-backward, and forward-backward mapping using the General Equivalence Mappings. Read More

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Malassezia infection associated with chronic spontaneous urticaria without angioedema: a report on five cases.

Acta Dermatovenerol Alp Pannonica Adriat 2018 06;27(2):65-69

Nashik District Maratha Vidya Prasarak Samaj Medical College, Nashik, India.

Introduction: Chronic spontaneous urticaria (CSU) is a challenging condition to treat and it significantly affects quality of life. Bacterial, viral, parasitic, and fungal infections have been associated with triggering and/or perpetuating urticaria in certain individuals. There is a paucity of literature on CSU associated with Malassezia infection. Read More

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Alergólogica 2015: A National Survey on Allergic Diseases in the Adult Spanish Population.

J Investig Allergol Clin Immunol 2018 Jun;28(3):151-164

Facultad de Medicina, Universidad San Pablo CEU, Madrid, Spain.

Background And Objetive: The frequency of allergic diseases is increasing worldwide, particularly in industrialized countries. From a clinical, management, and public heath perspective, it is important to determine the reasons for consulting an allergist, the distribution by frequency of allergic diseases, and how health care is provided. Objective: Alergológica 2015 was carried out to obtain information on clinical practice in allergy departments in Spain, and compare it with the previous study editions. Read More

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Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation.

J Allergy Clin Immunol 2018 Jun 21. Epub 2018 Jun 21.

CSL Limited, BIO21 Institute, Parkville, Victoria 3010. Australia. Electronic address:

HAE results in swelling due to KKS dysregulation and bradykinin production. FXII initiates the KKS and we have developed a human antibody that potently inhibits FXII protease activity as a novel prophylactic therapy for HAE. Read More

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June 2018
2 Reads

Omalizumab in chronic spontaneous urticaria patients nonresponsive to H1-antihistamine treatment: Results of the phase IV open-label SUNRISE study.

Br J Dermatol 2018 Jun 21. Epub 2018 Jun 21.

Dermatology Department, University Hospital of Nice, France.

Background: Omalizumab is approved as an add-on therapy for the treatment of chronic spontaneous urticaria (CSU) in patients with inadequate response to H1-anti-histamine treatment. The urticaria control test (UCT) is a reliable, brief tool developed as an alternative to the 7-day urticaria activity score (UAS7)-the standard for CSU disease activity assessment.

Objective: This prospective, open-label, phase IV study evaluated the efficacy and safety of omalizumab in French adult patients with CSU nonresponsive to H1-antihistamine treatment. Read More

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June 2018
1 Read

Hereditary angioedema: The plasma contact system out of control.

J Thromb Haemost 2018 Jun 19. Epub 2018 Jun 19.

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, the Netherlands.

The plasma contact system contributes to thrombosis in experimental models. Even though our standard blood coagulation tests are prolonged when plasma lacks contact factors, this enzyme system appears to have a minor (if any) role in haemostasis. In this review, we will explore the clinical phenotype of C1 esterase inhibitor (C1-INH) deficiency. Read More

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Tired and Swollen: A Mono Mimic for Angioedema.

Ann Allergy Asthma Immunol 2018 Jun 16. Epub 2018 Jun 16.

University of California, San Diego.

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Fixed drug eruption due To 2,3-dimercapto-1-propanesulfonic acid (DMPS) treatment for mercury poisoning: a rare adverse effect.

Acta Clin Belg 2018 Jun 18:1-3. Epub 2018 Jun 18.

d Department of Public Health, Faculty of Medicine , Yıldırım Beyazıt University , Ankara , Turkey.

Background Fixed drug eruptions (FDE) are characterized by recurrent, usually solitary erythematous or dark red macular, plaque or bullous lesions, all at the same site. Among the first choices for antidotal treatment in mercury exposure, 2,3-dimercapto-1-propanesulfonic acid (DMPS) is generally a drug with a low incidence of side effects. FDE due to DMPS was not detected in our literature research and so we aimed to present this rare case. Read More

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June 2018
3 Reads

Severe angioedema of laryngeal inlet in a woman receiving telmisartan therapy undergoing breast conservation surgery.

Indian J Anaesth 2018 May;62(5):393-395

Department of Surgical Oncology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

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Update on the Use of C1-Esterase Inhibitor Replacement Therapy in the Acute and Prophylactic Treatment of Hereditary Angioedema.

Clin Rev Allergy Immunol 2018 Jun 16. Epub 2018 Jun 16.

Allergy, Asthma and Immunology, 23-00 Route 208 South, Fair Lawn, NJ, 07410, USA.

In the vast majority of patients with hereditary angioedema (HAE), angioedema attacks are due to the quantitative or functional deficiency of C1-esterase inhibitor (C1-INH), which leads to increased vascular permeability and unregulated release of bradykinin. Exogenous administration of C1-INH is a rational way to restore the concentration and functional activity of this protein, regulate the release of bradykinin, and attenuate or prevent subcutaneous and submucosal edema associated with HAE. Recent international guidelines for the management of HAE include C1-INH as an option for acute treatment of HAE. Read More

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June 2018
6 Reads

Topical application of 5-fluorouracil 5 percent cream associated with severe neutropenia: discussion of a case and review of systemic reactions after topical treatment with 5-fluorouracil.

Authors:
Philip R Cohen

Dermatol Online J 2018 Apr 15;24(4). Epub 2018 Apr 15.

Department of Dermatology, University of California San Diego, La Jolla, California.

5-fluorouracil, a fluoropyrimidine antineoplastic drug, is used to topically treat actinic keratoses. Local skin reactions to the medication are common and anticipated. However, severe adverse events from topical 5-fluorouracil are rare and unexpected. Read More

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April 2018
5 Reads

Efficacy and Safety of Mepolizumab (Anti-Interleukin-5) Treatment in Gleich's Syndrome.

Front Immunol 2018 29;9:1198. Epub 2018 May 29.

Department of Biomedicine, Immunoallergology Unit, AOU Careggi, Florence, Italy.

Gleich's syndrome (GS) is characterized by recurrent episodes of angioedema, increase in body weight, fever, hypereosinophilia, and elevated serum IgM. The exact etiology remains unclear. Currently, the only treatment strategy is the administration of high dose of steroids during the acute phases. Read More

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May 2018
5 Reads

Natural course and prognostic factors of chronic urticaria in Korean children: A single center experience.

Asian Pac J Allergy Immunol 2018 Jun 11. Epub 2018 Jun 11.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Chronic urticaria (CU) has an adverse effect on academic achievement and psychosocial development in children.

Objective: We aimed to investigate the natural course of CU and to identify relevant factors associated with a poor CU prognosis in Korean children.

Methods: We retrospectively analyzed 253 children with episodes of wheals or angioedema at least 3 times a week that persisted for at least 6 weeks. Read More

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June 2018
3 Reads

SERPING1 and F12 combined variants in a hereditary angioedema family.

Ann Allergy Asthma Immunol 2018 Jun 6. Epub 2018 Jun 6.

Université Grenoble Alpes, GREPI, UE7408, Grenoble 38043, France.

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June 2018
1 Read

ACE Inhibitor-Induced Angioedema: a Review.

Curr Hypertens Rep 2018 Jun 8;20(7):55. Epub 2018 Jun 8.

Rutgers Robert Wood Johnson Medical School, Cardiovascular Institute, 125 Paterson Street, CAB-4100, New Brunswick, NJ, 08901, USA.

Purpose Of Review: This study aims to examine current knowledge on the occurrence, pathophysiology, and treatment of angioedema among patients who receive angiotensin-converting enzyme inhibitors.

Recent Findings: Angiotensin-converting enzyme inhibitors (ACE-I), a medication class used by an estimated 40 million people worldwide, are associated with angioedema that occurs with incidence ranging from 0.1 to 0. Read More

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Case report presenting the diagnostic challenges in a patient with recurrent acquired angioedema, antiphospholipid antibodies and undetectable C2 levels.

Allergy Asthma Clin Immunol 2018 4;14:24. Epub 2018 Jun 4.

Western Springs Asthma and Allergy, Western Spring, IL USA.

Background: Angioedema secondary to acquired C1 inhibitor deficiency (AAE) is a rare disease. It usually is associated with lymphoproliferative disorders. We present a case of AAE in a patient with antiphospholipid syndrome (APS), a non-Hodgkin lymphoproliferative disorder (NHL) with undetectable levels of C2, C4, and an undetectable CH50. Read More

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June 2018
1 Read

NSAIDs hypersensitivity: questions not resolved.

Curr Opin Allergy Clin Immunol 2018 Aug;18(4):291-301

Allergy Service Infanta Leonor University Hospital.

Purpose Of Review: NSAIDs are the drugs most frequently involved in hypersensitivity reactions (HSR). These are frequently prescribed at all ages. HSR are of great concern and can affect people at any age. Read More

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Impaired Endothelial Function in Hereditary Angioedema During the Symptom-Free Period.

Front Physiol 2018 16;9:523. Epub 2018 May 16.

Unit of Internal Medicine, Department of Medical Sciences and Public Health, Allergy and Clinical Immunology, University of Cagliari, Cagliari, Italy.

The presence of coronary endothelial dysfunction was previously shown in Hereditary Angioedema (HAE) patients. The aim of our study was to evaluate the effect of HAE on systemic endothelial function and whether there was a relationship among endothelial function, asymmetric dimethylarginine (ADMA) -which is a strong inhibitor of nitric oxide synthesis-, and disease severity scores. Twenty-four HAE patients (18 females, aged 47. Read More

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Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema.

Orphanet J Rare Dis 2018 Jun 5;13(1):90. Epub 2018 Jun 5.

Division of Allergology, Department of Rheumatology,Immunology and Allergology, University Hospital Berne, Berne, Switzerland.

Background: Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare inherited disease. In most HAE-affected subjects, defined trigger factors precede angioedema attacks. Mechanisms of how trigger factors stimulate the contact activation pathway with bradykinin generation are not well elucidated. Read More

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The Diagnosis of Hereditary Angioedema: Family Caregivers' Experiences.

Clin Nurs Res 2018 Jun 1:1054773818780102. Epub 2018 Jun 1.

1 University of Almeria, Spain.

The aim of this study was to understand the experiences of family caregivers in the process of diagnosing hereditary angioedema. An interpretive and qualitative research methodology based on Gadamer's philosophical hermeneutics was carried out. Data collection took place between May 2015 and August 2016 and included a focus group and in-depth interviews with 16 family caregivers. Read More

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June 2018
2 Reads

Angioedema: A Life-threatening Complication of Tissue Plasminogen Activator.

Cureus 2018 Mar 29;10(3):e2392. Epub 2018 Mar 29.

Internal Medicine, John H Stroger J. Hospital of Cook County.

Angioedema is a localized, non-pitting, non-dependent, submucosal, and subcutaneous swelling resulting from the extravasation of fluid into the interstitium due to the increased production of plasma kinins and histamine. It can present with urticaria or anaphylaxis and is usually associated with angiotensin-converting enzyme inhibitors (ACEis), complement deficiencies, or the side effects of tissue plasminogen activator (tPA). Orolingual angioedema following tPA for acute ischemic stroke is a transient, self-resolving hemifacial swelling contralateral to neurological deficits that can rarely progress to the airway, compromising it and leading to a life-threatening situation if not managed promptly. Read More

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