7,780 results match your criteria Angioedema
Photodermatol Photoimmunol Photomed 2018 Dec 5. Epub 2018 Dec 5.
Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.
Solar angioedema is a rare photodermatosis, with only 11 reported patients worldwide. Patients develop facial (predominately eyelids, lips) and/or acral swelling hours after sun exposure, especially while on vacation to tropical areas. Management includes photoprotection and sun avoidance; preemptive antihistamines have been tried with minimal effect. Read More
Ann Allergy Asthma Immunol 2018 Nov 30. Epub 2018 Nov 30.
Department of Biophysics, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Hautarzt 2018 Nov 30. Epub 2018 Nov 30.
Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
Background: The classification of angioedema in daily clinical practice is often challenging.
Objectives: The goal is to review the most recent classification of angioedema and to discuss the underlying pathology.
Materials And Methods: Current guidelines and research on the pathophysiology and classification of angioedema were evaluated. Read More
World J Otorhinolaryngol Head Neck Surg 2018 Sep 5;4(3):162-168. Epub 2018 Sep 5.
Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA, USA.
It is well-established that following ingestion of aspirin or any other inhibitor of cyclooxygenase-1, patients with Samter's disease, or aspirin-exacerbated respiratory disease (AERD) develop the sudden onset of worsening respiratory clinical symptoms, which usually involves nasal congestion, rhinorrhea, wheezing and bronchospasm. Gastrointestinal distress, nausea, a pruritic rash and angioedema can also occasionally develop. However, the underlying pathologic mechanism that drives these clinical reactions remains elusive. Read More
Anticancer Res 2018 Dec;38(12):6801-6807
Internal Medicine Department, Tor Vergata University Hospital, Medical Oncology Unit, Rome, Italy.
Background: Hereditary angioedema (HAE) is an autosomal dominant hereditary disorder characterized by episodic swelling of many body regions (especially throat and abdomen), potentially triggered by medication. No data are available for HAE in patients with cancer assigned to standard chemotherapy. The aim of our study was to identify circulating mediators potentially predictive of acute HAE attacks during chemotherapy. Read More
Eurasian J Med 2018 Oct;50(3):152-155
Division of Allergy and Immunology, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey.
Objective: To determine the relationship between adenoidectomy and/or tonsillectomy in childhood and allergic diseases in adulthood.
Materials And Methods: A survey investigating the history of adenoidectomy and/or tonsillectomy was administered to patients that were followed-up by our department between January and June 2014 with the diagnosis of asthma, allergic rhinitis, urticaria-angioedema, drug allergy, food allergy, and venom allergy; patients willing to participate were included in the study. The relationship and risk ratios were analyzed. Read More
J Med Case Rep 2018 Dec 5;12(1):359. Epub 2018 Dec 5.
Pharmaceutical Care Department, Alansar Hospital, Al Madinah, Al Munawarah, Saudi Arabia.
Background: Ace inhibitor-induced angioedema, characterized by sudden-onset swelling of the mucous membrane, skin, or both, is a rare occurrence in the Kingdom of Saudi Arabia. Because of its safety and efficacy, perindopril is a commonly prescribed angiotensin-converting enzyme inhibitor. Here we describe the clinical manifestations, management, and outcome of perindopril-induced angioedema of the lips and tongue in a 65-year-old Saudi man. Read More
J Allergy Clin Immunol Pract 2018 Dec 1. Epub 2018 Dec 1.
Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:
Background: Hypersensitivity reactions (HSRs) are immunologic responses to drugs. Identification of HSRs documented in the electronic health record (EHR) is important for patient safety.
Objective: To examine HSR epidemiology using longitudinal EHR data from a large United States healthcare system. Read More
J Dermatolog Treat 2018 Dec 4:1-4. Epub 2018 Dec 4.
a Allergology and Immunology Clinic , Operative Unit of Medicine , Policoro Hospital, Matera , Italy .
Uvula oedema is a condition characterized by a sensation of a foreign body in the oropharynx and difficulty to speak; sometimes, if associated to glottis oedema, difficulty to breathe and dysphonia are also present. Urticaria is a disease characterized by itching wheals on the skin, and sometimes angioedema. Chronic urticaria is spontaneous when the aetiology is unknown. Read More
Case Reports Immunol 2018 29;2018:7435870. Epub 2018 Oct 29.
Cleveland Clinic Abu Dhabi, UAE.
A 27-year-old Emirate man presented to Cleveland Clinic Abu Dhabi emergency department with a 4 year history of recurrent episodes of severe swellings affecting different parts of his body. He used to get 2 swelling episodes every week affecting either his face, hands, feet or scrotum and severe abdominal pain twice a week. Abdominal CT scan and a colonoscopy showed bowel wall oedema. Read More
JAMA 2018 11;320(20):2108-2121
Department of Dermatology and Allergy, Dermatological Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Importance: Current treatments for long-term prophylaxis in hereditary angioedema have limitations.
Objective: To assess the efficacy of lanadelumab, a fully human monoclonal antibody that selectively inhibits active plasma kallikrein, in preventing hereditary angioedema attacks.
Design, Setting, And Participants: Phase 3, randomized, double-blind, parallel-group, placebo-controlled trial conducted at 41 sites in Canada, Europe, Jordan, and the United States. Read More
Allergy Asthma Clin Immunol 2018 21;14:83. Epub 2018 Nov 21.
10GREPI EA7408, University Grenoble Alpes, Grenoble, France.
Background: Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is an autosomal dominant disease resulting in random and unpredictable attacks of swelling. The swelling in C1-INH-HAE is a result of impaired regulation of bradykinin production. The fact that the array of tests needed to diagnose HAE is not always available to the treating physicians is challenging for them and their patients. Read More
Immunobiology 2018 Nov 13. Epub 2018 Nov 13.
Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, Pavia, Italy.
Introduction: Chronic spontaneous urticaria (CSU) is characterized by recurrent itchy wheals, angioedema or both, that persist for longer than six weeks. In children, up to 40% of chronic spontaneous urticaria is due to mast cells and basophils-activating autoantibodies, mostly directed against the IgE high-affinity receptor subunit (FcεRI). Indirect basophil activation test (BAT) has been proposed in the diagnosis of autoimmune urticaria. Read More
World Allergy Organ J 2018 16;11(1):32. Epub 2018 Nov 16.
17Novartis Pharma AG, Basel, Switzerland.
Background: Global chronic urticaria (CU) disease experience and management is not well documented. This study descriptively compares these aspects among CU patients residing in Europe (EU) and Central and South America (C/SA).
Methods: AWARE (A World-wide Antihistamine-Refractory chronic urticaria patient Evaluation) is a global prospective, non-interventional study of CU in the real-world setting. Read More
RNA 2018 Nov 21. Epub 2018 Nov 21.
Background: Hereditary angioedema (HAE) is a genetic disorder mostly caused by mutations in the C1 esterase inhibitor gene (C1INH) that results in poor control of contact pathway activation and excess bradykinin generation. Bradykinin increases vascular permeability and is ultimately responsible for the episodes of swelling characteristic of HAE.
Objective: We hypothesized that the use of RNA interference (RNAi) to reduce plasma Factor XII (FXII), which initiates the contact pathway signaling cascade, would reduce contact pathway activation and prevent excessive bradykinin generation. Read More
J Dtsch Dermatol Ges 2018 Nov 21. Epub 2018 Nov 21.
Department of Oto-Rhino-Laryngology Head and Neck Surgery, Ulm University Medical Center, Germany.
Background: Hereditary angioedema (HAE) is a rare genetic disorder that leads to recurrent development of mucosal and dermal swelling. It is mediated by bradykinin, and can affect virtually any part of the human body, including the gastrointestinal tract, the extremities, and the laryngeal and pharyngeal regions. Safe and potent drugs are available for acute and prophylactic treatment of HAE. Read More
Braz J Med Biol Res 2018 Nov 14;51(12):e7813. Epub 2018 Nov 14.
Disciplina de Imunologia Clínica, Faculdade de Medicina do ABC, Santo André, SP, Brasil.
Hereditary angioedema (HAE) is a rare autosomal dominant disease due to C1 esterase inhibitor deficiency (C1-INH). The disease is characterized by subcutaneous and submucosal edema in the absence of urticaria due to the accumulation of bradykinin. This descriptive study aimed to evaluate the clinical characteristics of patients with a confirmed diagnosis of HAE referred to our Outpatient Clinic between December 2009 and November 2017. Read More
J Eur Acad Dermatol Venereol 2018 Nov 19. Epub 2018 Nov 19.
Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, Italy.
Background: Chronic spontaneous urticaria (CSU) is defined as spontaneous occurrence of wheals and/or angioedema for ≥6 weeks. Omalizumab is a monoclonal anti-IgE antibody effective in refractory CSU, but its mechanism of action and markers predictive of response remain not completely defined.
Objectives: To correlate baseline levels of two proposed biomarkers, total IgE (bIgE) and d-dimer (bd-dimer), and clinical parameters to omalizumab response and to relapses after drug withdrawal. Read More
J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.
Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La Grange Park, IL. Electronic address:
Acquired cold urticaria (ACU) is characterized by the development of wheals, angioedema, or both after cold exposure. Age at diagnosis, disease severity, and response to the ice cube challenge test predicted both prognosis and response to therapy. Proper characterization of the type of acquired cold urticaria allows for appropriate counseling and choice of therapy. Read More
J Allergy Clin Immunol 2018 Nov 13. Epub 2018 Nov 13.
Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité-Universitätsmedizin, Berlin 10117, Germany.
Mild forms of vibratory angioedema/pruritus are more common than expected. As the ADGRE2-mutation causing familiar vibratory angioedema was not seen in the population investigated, at least two subtypes must exist. Read More
Clin Pract Cases Emerg Med 2018 Nov 28;2(4):291-293. Epub 2018 Sep 28.
University of California, Irvine, Department of Emergency Medicine, Orange, California.
Isolated angioedema of the uvula, or Quincke's disease, is a rare condition that can cause respiratory compromise. Although typically self-limiting, episodes of angioedema may require prompt therapy to prevent obstruction of the proximal airway. In this case report we review the appropriate steps for initial evaluation of patients with suspected angioedema, primary etiologies, and appropriate initial therapy. Read More
Acta Clin Croat 2018 Jun;57(2):342-351
Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Although cheilitis as a term describing lip inflammation has been identified and recognized for a long time, until now there have been no clear recommendations for its work-up and classification. The disease may appear as an isolated condition or as part of certain systemic diseases/conditions (such as anemia due to vitamin B12 or iron deficiency) or local infections (e.g. Read More
J Dermatolog Treat 2018 Nov 14:1-7. Epub 2018 Nov 14.
a 1 University Department Pro.Sa.M.I. "G. D'Alessandro", University of Palermo , Italy.
Chronic spontaneous urticaria is a clinical condition characterized by spontaneous or inducible recurrent wheals. This condition may significantly affect quality of life of patients and of their families. Aetiology is not identified in 25-85% of cases that are indicated as "idiopathic", because all diagnostic tests are negative. Read More
Case Rep Emerg Med 2018 22;2018:6363787. Epub 2018 Oct 22.
Romanian Network for Hereditary Angioedema, 11a Sântana St, 540256 Tîrgu-Mureş, Romania.
Emergency department (ED) physicians frequently encounter patients presenting with angioedema. Most of these involve histamine-mediated angioedema; however, less common forms of angioedema (bradykinin-mediated) also occur. It is vital physicians correctly recognize and treat this; particularly since bradykinin-mediated angioedema does not respond to antihistamines, corticosteroids or epinephrine and hereditary angioedema (HAE) laryngeal attacks can be fatal. Read More
Air Med J 2018 Nov - Dec;37(6):336-338. Epub 2018 Oct 15.
Allergy 2018 Nov 13. Epub 2018 Nov 13.
Department of Medical Sciences and Public Health, University of Cagliari.
Sci Rep 2018 Nov 12;8(1):16710. Epub 2018 Nov 12.
Allergy Unit, IBIMA-Regional University Hospital of Malaga-UMA, Malaga, Spain.
Non-steroidal anti-inflammatory drugs (NSAIDs)-induced hypersensitivity reactions are classified by the European Network on Drug Allergy (ENDA) as either cross-reactive or selective. The former is the most frequent type and includes patients with exclusively respiratory symptoms (NSAIDs-exacerbated respiratory disease, NERD) or exclusively cutaneous symptoms: NSAIDs-induced urticaria/angioedema (NIUA); and NSAIDs-exacerbated cutaneous disease (NECD). However, although not reflected in the current classification scheme (ENDA), in clinical practice a combination of both skin and respiratory symptoms or even other organs such as gastrointestinal tract symptoms (mixed or blended reactions) is frequently observed. Read More
Presse Med 2018 Nov 8. Epub 2018 Nov 8.
Centre de référence national des angioedèmes (CREAK), 38043 Grenoble, France; Service d'immunologie, CHUGA, 38043 Grenoble, France.
Bradykinin mediated angioedema (BK-AE) can be associated either with C1Inhibitor deficiency (hereditary and acquired forms), either with normal C1Inh (hereditary form and drug induced AE as angiotensin converting enzyme inhibitors…). In case of high clinical suspicion of BK-AE, C1Inh exploration must be done at first: C1Inh function and antigenemy as well as C4 concentration. C1Inh deficiency is significant if the tests are below 50 % of the normal values and controlled a second time. Read More
N Engl J Med 2018 Nov 11. Epub 2018 Nov 11.
From the Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (E.J.V.); the Thrombolysis in Myocardial Infarction Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (D.A.M., E.B.); Duke Clinical Research Institute, Duke University, Durham, NC (A.D.D.); Novartis Pharmaceuticals, East Hanover, NJ (C.I.D., K.M., R.R.); and the Division of Cardiology, Permanente Medical Group, San Francisco, and the Division of Research, Kaiser Permanente Northern California, Oakland - both in California (A.P.A.).
Background: Acute decompensated heart failure accounts for more than 1 million hospitalizations in the United States annually. Whether the initiation of sacubitril-valsartan therapy is safe and effective among patients who are hospitalized for acute decompensated heart failure is unknown.
Methods: We enrolled patients with heart failure with reduced ejection fraction who were hospitalized for acute decompensated heart failure at 129 sites in the United States. Read More
Clin Exp Allergy 2018 Nov 11. Epub 2018 Nov 11.
Novartis Pharma AG, Basel, Switzerland.
Background: Previous reports indicate that patients with chronic spontaneous urticaria (CSU) are undertreated and that physicians show poor adherence to guideline recommendations. Awareness of CSU has improved in recent years, but it remains unclear if this has improved the management of these patients in clinical practice.
Objective: To describe disease burden, quality of life (QoL), and treatment patterns of patients with H -antihistamine-refractory CSU in Germany. Read More
Nat Biotechnol 2018 Nov;36(11):1027
Skin Appendage Disord 2018 Oct 22;4(4):261-263. Epub 2018 Mar 22.
Department of Dermatology, University of California, Irvine, Irvine, California, USA.
Alopecia areata (AA) is an autoimmune disorder in which immune attack of the anagen follicle causes hair loss in approximately 2% of the population. Although the pathogenesis of AA has not been fully determined, most likely it is mediated by a variety of factors including cellular/humoral immunity and genetic predisposition. Researchers have been interested in the possible role of the complement pathway in AA since the 1970s. Read More
Asia Pac Allergy 2018 Oct 23;8(4):e38. Epub 2018 Oct 23.
Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore 308433.
Nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity reactions (HSRs) are often nonimmunologically mediated reactions which present with immediate HSR type manifestations. These are mediated by cyclooxygenase inhibition resulting in shunting towards the excessive production of leukotrienes. Important disease associations include asthma, nasal polyposis, and chronic spontaneous urticaria, especially among adults. Read More
Int Arch Allergy Immunol 2018 6;177(4):324-333. Epub 2018 Nov 6.
Allergic diseases are of great concern because of their high prevalence, which is still rising in several regions, their impact on patients' physical and psychological health, the huge burden they place on patients' quality of life, as well as the socioeconomic consequences that they cause. Recent research has provided new data on both genetic and environmental risk factors of atopic/allergic diseases. The application of new technologies such as "omics" has allowed a better understanding of the pathogenesis and has helped with the identification of therapeutic targets. Read More
J Clin Invest 2018 Nov 6. Epub 2018 Nov 6.
Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent edema attacks associated with morbidity and mortality. HAE results from variations in the SERPING1 gene encoding C1 inhibitor (C1INH), a serine protease inhibitor (serpin). Reduced plasma levels of C1INH lead to enhanced activation of the contact system triggering high levels of bradykinin and increased vascular permeability, but the cellular mechanisms leading to low C1INH levels (20-30% of normal) in heterozygous HAE type I patients remain obscure. Read More
Int J Radiat Oncol Biol Phys 2018 Nov 2. Epub 2018 Nov 2.
Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida.
Purpose: Chemoradiation (CRT) is an integral treatment modality for patients with locally advanced lung cancer. It has been hypothesized that current use of an angiotensin-converting enzyme inhibitor during CRT may be protective for treatment-related lung damage and pneumonitis.
Methods And Materials: We conducted a pilot, double-blind, placebo-controlled randomized trial. Read More
J Thromb Haemost 2018 Nov 5. Epub 2018 Nov 5.
Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Background: The contact activation system and innate immune system are interlinked in inflammatory pathology. Plasma kallikrein (PKa) is held responsible for the step-wise processing of factor XII (FXII). A first cleavage activates FXII (into FXIIa); subsequent cleavages truncate it. Read More
J Stroke Cerebrovasc Dis 2018 Nov 1. Epub 2018 Nov 1.
Institute for Stroke and Cerebrovascular Disease, Houston, TX; University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX. Electronic address:
Background: Stroke outcomes have been shown to be worse for patients presenting overnight and on weekends (after-hours) to stroke centers compared with those presenting during business hours (on-hours). Telemedicine (TM) helps provide evaluation and safe management of stroke patients. We compared time metrics and outcomes of stroke patients who were assessed and received intravenous recombinant tissue plasminogen activator (IV-tPA) via TM during after-hours with those during on-hours. Read More
Acta Dermatovenerol Croat 2018 Oct;26(3):276-277
Assoc. Prof. Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology University Hospital Center Zagreb School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;
Autoimmune progesterone dermatitis (APD) is rare autoimmune response to endogenous progesterone or to earlier exposure to exogenous progesterone (1). Skin lesions typically occur due to increases in progesterone during the luteal phase of the menstrual cycle (2). A-31-year-old mother of two children presented to our Department with a 5-year history of pruritic and painful erythematosus macules, papules, and patches on her neck, pectoral region, and face, which appeared 2-3 days before the onset of menses and gradually resolved 7-10 days later (Figure 1). Read More
Forensic Sci Med Pathol 2018 Nov 3. Epub 2018 Nov 3.
Forensic Science SA, 21 Divett Place, Adelaide, 5000, Australia.
An 86-year-old woman with a history of angioedema was found dead at her home address. She had recently complained of a swollen tongue. At autopsy the tongue was grossly edematous, protruding from the mouth. Read More
Gene 2018 Oct 30;685:179-185. Epub 2018 Oct 30.
Center for Research and Molecular Diagnosis of Genetic Diseases, Department of Biophysics, Federal University of São Paulo, Rua Pedro de Toledo, 669, 9° andar, Vila Clementino, 04039-032 São Paulo, SP, Brazil. Electronic address:
Background: Hereditary angioedema (HAE) is a rare genetic disorder mainly caused by mutations in the SERPING1 gene, determining a deficit of C1 inhibitor (C1-INH). In approximately 10% of the cases, HAE with C1-INH deficiency (C1-INH-HAE) is caused by large gene rearrangements, which are not detected by Sanger sequencing. Here we present the exon quantification technique (EQT), a molecular diagnostic test for the detection of large genetic rearrangements in SERPING1, mapping the exact size and location of the deletion caused by the recombination of Alu elements. Read More
Allergy Asthma Clin Immunol 2018 25;14:75. Epub 2018 Oct 25.
1Clinical Center of Allergology, Clinic of Allergy and Asthma, University Hospital "Alexandrovska", Medical University of Sofia, 1, Georgi Sofiiski Str., 1431 Sofia, Bulgaria.
Background: Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare autosomal dominant disease characterized by episodes of acute subcutaneous swelling, and/or recurrent severe abdominal pain. The disease is potentially fatal if the upper-airway is involved. Iatrogenic harm can occur if HAE is not considered in the differential diagnosis, the specialists are not aware of the natural history, diagnosis and treatment of HAE, or as a result of unnecessary surgical and other iatrogenic interventions. Read More
Allergy Asthma Clin Immunol 2018 25;14:69. Epub 2018 Oct 25.
1Carol Davila University of Medicine and Pharmacy, Bulevardul Eroii Sanitari, no. 8, District 5, 050474 Bucharest, Romania.
Background: Angioedema due to acquired deficiency of C1-inhibitor (C1-INH-AAE) is a rare disease sharing some clinical and laboratory similarities with hereditary angioedema, but with late onset and no positive family history. The underlining cause may be malignant or due to autoimmune diseases, but some cases remain idiopathic.
Case Presentation: We report a case of a 75 year old woman suffering from recurrent episodes of angioedema since the age of 66, considered first induced by treatment with angiotensin-converting-enzyme inhibitors (ACEI). Read More
Allergy Asthma Clin Immunol 2018 25;14:44. Epub 2018 Oct 25.
Barts Health, Grahame Hayton Unit, Ambrose King Centre, The Royal London Hospital, Whitechapel, London, E1 1BB UK.
Background: Hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency is characterized by recurrent swelling attacks that can be life-threatening if left untreated. Prompt treatment is vital during acute attacks; plasma-derived C1-INH (Berinert) is one treatment currently licensed for the intravenous treatment of acute HAE attacks in adults, adolescents and children. A new, volume-reduced formulation, of C1-INH is currently available which aims to reduce the time to treatment, and provide greater convenience to patients and healthcare professionals. Read More
J Allergy Clin Immunol Pract 2018 Oct 25. Epub 2018 Oct 25.
Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Adv Emerg Nurs J 2018 Oct/Dec;40(4):E1
Adv Emerg Nurs J 2018 Oct/Dec;40(4):267-277
Department of Pharmacy, Loyola University Medical Center, Maywood, Illinois (Drs Hirschy, Shah, and Rech); and Department of Pharmacy, Novant Health-Forsyth Medical Center, Winston-Salem, North Carolina (Dr Davis).
Incidence of angioedema associated with angiotensin-converting enzyme inhibitors (ACE-I) has been estimated at 0.1%-2.2% of patients receiving treatment. Read More
Pan Afr Med J 2018 6;30:103. Epub 2018 Jun 6.
Division of Dermatology, Groote Schuur Hospital, University of Cape Town, Observatory Cape Town, South Africa.
Angioedema is a type-1 hypersensitivity reaction that can be life threatening. It affects the skin airways and the gastrointestinal tract. Henna is a green powder used to dye skin and nails. Read More
Crit Care Res Pract 2018 27;2018:9360918. Epub 2018 Sep 27.
Beaumont Health-Royal Oak, 3601 W. 13 Mile Rd., Royal Oak, MI 48073, USA.
Introduction: Tissue plasminogen activator (tPA) is commonly used in ischemic cerebral vascular accidents (CVAs). tPA is generally well tolerated; however, orolingual angioedema is a well-documented adverse effect. Angioedema is generally mild, transient, and unilateral but can manifest as severe, life-threatening upper airway obstruction requiring intubation. Read More
Stroke 2018 Sep;49(9):2211-2219
From the Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China (Q.-F.C., J.-Y.H.).
Background and Purpose- tPA (tissue-type plasminogen activator) is the only recommended intravenous thrombolytic agent for ischemic stroke. However, its application is limited because of increased risk of hemorrhagic transformation beyond the time window. T541 is a Chinese compound medicine with potential to attenuate ischemia and reperfusion injury. Read More