9,396 results match your criteria Angioedema

Food-dependent Exercise-induced Wheals, Angioedema, and Anaphylaxis: A Systematic Review.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany.

Background: Food-dependent exercise-induced wheals, angioedema, and anaphylaxis remain insufficiently characterized.

Objective: We systematically reviewed the literature on clinical manifestations, laboratory investigations, culprit foods, triggering exercise, comorbidities, and treatment outcomes.

Methods: Using predefined search terms and Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) recommendations, we searched three electronic databases to identify relevant literature published before July 2021. Read More

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Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci.

Eur Heart J 2022 Jun 25. Epub 2022 Jun 25.

Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Building 9312, Henrik Harpestrengs Vej 4C, 2100 Copenhagen, Denmark.

Aims: To search for sequence variants associated with ACEi discontinuation and to test their association with ACEi-associated adverse drug reactions (ADRs).

Methods And Results: A genome-wide association study (GWAS) on ACEi discontinuation was conducted, including 33 959 ACEi-discontinuers and 44 041 controls. Cases were defined as persons who switched from an ACEi treatment to an angiotensin receptor blocker. Read More

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Non-episodic angioedema associated with eosinophilia.

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Shimotsuga, Tochigi, Japan.

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Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies.

Medicina (Kaunas) 2022 Jun 17;58(6). Epub 2022 Jun 17.

Dermatology Department, "Elias" University Emergency Hospital, 011461 Bucharest, Romania.

Chronic spontaneous urticaria (CSU) considerably alters patients' quality of life, often for extended periods, due to pruriginous skin lesions, impaired sleep, unexpected development of angioedema, and failure of conventional treatments in properly controlling signs and symptoms. Recent research focused on the development of new therapeutic agents with higher efficacy. Although the production of specific immunoglobulin E (IgE) antibodies against certain allergens is not a characteristic of the disease, treatment with omalizumab, a monoclonal anti-IgE antibody, proved efficient and safe in patients with moderate to severe chronic spontaneous urticaria uncontrolled by H1-antihistamines. Read More

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Acta Clin Croat 2021 Dec;60(4):711-721

1Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 3Unit of Dermatology and Venereology, Zabok General Hospital, Bračak/Zabok, Croatia; 4Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 5Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Although there are many single case reports on paraneoplastic dermatoses in the literature, there are very rare articles containing multiple cases. A retrospective study was performed to examine paraneoplastic dermatoses and accompanying malignancies based on skin manifestations and appropriate diagnostic evaluations. We recorded outcomes, current conditions, and surgical/oncologic treatments. Read More

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December 2021

Hoagland sign: bilateral upper eyelid oedema.

BMJ Case Rep 2022 Jun 22;15(6). Epub 2022 Jun 22.

Department of General Internal Medicine, Okayama City Hospital, Okayama, Japan.

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Urticaria and angioedema in children and adolescents: diagnostic challenge.

Allergol Immunopathol (Madr) 2022 17;50(S Pt 1):17-29. Epub 2022 May 17.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Centre, Montreal, Canada.

Urticaria diagnosis may be challenging in children since it can be triggered or related to numerous conditions. In this paper, we reviewed the main aspects regarding the diagnosis of urticaria in the pediatric population. Acute urticaria is often due to viral infections. Read More

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Hereditary angioedema in children and adolescents.

Allergol Immunopathol (Madr) 2022 7;50(S Pt 1):1-6. Epub 2022 Apr 7.

Clinical Immunology, Centro Universitario FMABC, Santo André, Brazil;

Hereditary angioedema is a genetic disease with autosomal dominant inheritance and, in most cases, caused by C1 inhibitor deficiency. Patients present with recurrent edema affecting sub-cutaneous and mucus membranes with variable onset and severity. More than 50% of patients may become symptomatic before 10 years of age. Read More

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Management of suspected and confirmed COVID-19 (SARS-CoV-2) vaccine hypersensitivity.

Allergy 2022 Jun 20. Epub 2022 Jun 20.

Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München.

Systemic allergic reactions to vaccines are very rare. In this study we assessed the management and outcome of suspected SARS-CoV-2 vaccine hypersensitivity. 334 individuals underwent an allergy work up regarding SARS-CoV-2 vaccination (group A: 115 individuals suspected to be at increased risk for vaccine related reactions before vaccination and group B: 219 patients with reactions after COVID vaccination). Read More

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Overview of use, efficacy, and safety of dupilumab in complex patients: a retrospective, case-series study from a large, urban academic center.

Arch Dermatol Res 2022 Jun 18. Epub 2022 Jun 18.

Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

Dupilumab has emerged as an effective treatment option for those suffering from moderate-to-severe atopic dermatitis (AD). Since its approval in 2017 by the United States Food and Drug Administration, dupilumab demonstrated efficacy in a wide range of "off-label" dermatologic conditions. With its increasing use, dermatologists must navigate prescribing dupilumab in complex patient populations. Read More

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The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria.

Front Immunol 2022 31;13:879754. Epub 2022 May 31.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Chronic spontaneous urticaria (CSU) is defined as recurrent episodes of spontaneous wheal development and/or angioedema for more than six weeks and at least twice a week. The core link in the pathogenesis of CSU is the activation of mast cells, T cells, eosinophils, and other immune cells infiltrating around the small venules of the lesion. Increased vascular permeability, vasodilatation, and recruitment of inflammatory cells directly depend on mast cell mediators' release. Read More

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The symptom experience of hereditary angioedema (HAE) patients beyond HAE attacks: literature review and clinician interviews.

Orphanet J Rare Dis 2022 06 16;17(1):232. Epub 2022 Jun 16.

Evidera, 615 2nd Ave Ste 500, Seattle, WA, 98104, USA.

Background: Hereditary angioedema (HAE) is a genetic disorder characterized by re-occurring swelling episodes called "attacks," usually in the limbs, face, airways, and intestinal tract. New prophylactic therapies have reduced the frequency of these attacks. This study describes results from a literature review and clinician interviews assessing patient HAE symptom experiences and timing, and then evaluates whether existing patient-reported outcome (PRO) tools adequately reflect this experience. Read More

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Novel Plasma Kallikrein Inhibitors for Treating Hereditary Angioedema, Diabetic Macular Edema, and Diabetic Retinopathy.

Ram W Sabnis

ACS Med Chem Lett 2022 Jun 13;13(6):883-884. Epub 2022 May 13.

Smith, Gambrell & Russell LLP, 1105 West Peachtree Street NE, Suite 1000, Atlanta, Georgia 30309, United States.

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Artificial intelligence processing electronic health records to identify commonalities and comorbidities cluster at Immuno Center Humanitas.

Clin Transl Allergy 2022 Jun 8;12(6):e12144. Epub 2022 Jun 8.

Department of Biomedical Sciences Humanitas University Milan Italy.

Background: Comorbidities are common in chronic inflammatory conditions, requiring multidisciplinary treatment approach. Understanding the link between a single disease and its comorbidities is important for appropriate treatment and management. We evaluate the ability of an NLP-based process for knowledge discovery to detect information about pathologies, patients' phenotype, doctors' prescriptions and commonalities in electronic medical records, by extracting information from free narrative text written by clinicians during medical visits, resulting in the extraction of valuable information and enriching real world evidence data from a multidisciplinary setting. Read More

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Angiotensin II receptor blockers in dermatology: a narrative review.

J Dermatolog Treat 2022 Jun 27:1-5. Epub 2022 Jun 27.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Angiotensin II receptor blockers (ARBs) are commonly used for cardiovascular diseases, especially for patients who can't tolerate the side effects of cough and angioedema caused by angiotensin converting enzyme inhibitors (ACEIs). However, the evidence of using ARBs in dermatology is mostly anecdotal and limited to case reports or small case series. Here we present a narrative review focusing on the therapeutic use of ARBs in dermatology and adverse cutaneous reactions due to the administration of ARBs. Read More

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Patient perspectives on reproductive options for hereditary angioedema: A cross-sectional survey study.

J Allergy Clin Immunol Pract 2022 Jun 9. Epub 2022 Jun 9.

Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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Superior Vena Cava Syndrome Due to Thrombosis: A Case Report.

Cureus 2022 May 7;14(5):e24811. Epub 2022 May 7.

Pulmonary and Critical Care, Richmond University Medical Center, Staten Island, USA.

Superior vena cava (SVC) syndrome is a clinical entity with signs and symptoms resulting from obstruction of blood flow through the SVC. The resulting obstruction leads to edema in the upper body, including the head, neck, and upper extremities. Clinical signs and symptoms can include plethora, cyanosis, dyspnea, stridor, cough, and hoarseness, as well as more serious complications such as cerebral edema leading to headache, confusion, and coma. Read More

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Hypertensive Anaphylaxis After Moderna COVID-19 Vaccination: A Case Report.

Cureus 2022 Jun 1;14(6):e25586. Epub 2022 Jun 1.

Department of Hypertension and Nephrology, NTT Medical Centre Tokyo, Tokyo, JPN.

Hypotension after exposure to an allergen is a well-known indicator of an anaphylactic reaction. However, hypertensive anaphylaxis often goes unrecognized. Increased blood pressure can present as an anaphylactic reaction, which is called hypertensive anaphylaxis. Read More

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Autoimmune chronic spontaneous urticaria.

J Allergy Clin Immunol 2022 Jun;149(6):1819-1831

Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany. Electronic address:

Chronic spontaneous urticaria (CSU) is a debilitating mast cell-driven disease characterized by recurrent wheals and/or angioedema. Substantial progress has been made in dissecting the 2 main autoimmune mechanisms that drive the pathogenesis of CSU. Type I autoimmune (autoallergic) CSU is associated with IgE antibodies against autoantigens, for example, thyroid peroxidase and IL-24. Read More

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Enalapril-induced angioedema: A forgotten adverse event.

Clin Case Rep 2022 Jun 2;10(6):e05944. Epub 2022 Jun 2.

Department of Dermatology Universidad de Buenos Aires Buenos Aires Argentina.

Angioedema is an edema of skin, mucosa, respiratory, and gastrointestinal tract, due to vascular permeability increase, resulting in plasma extravasation, which has been associated with multiple causes. We describe a case of a patient who was prescribed with enalapril and presented with symptoms suggestive of angioedema. Read More

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[Impacted battery in the nose of a four-year-old girl].

Ugeskr Laeger 2022 May;184(20)

Øre-næse-halsafdelingen, Odense Universitetshospital.

In this case report, it was suspected that a four-year-old girl had an impacted toy in her nose. Initially, she was refused consultation due to a COVID-19 positive parent. Three days later she presented with nasal secretion and facial oedema. Read More

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Icatibant use in Brazilian patients with hereditary angioedema (HAE) type 1 or 2 and HAE with normal C1-INH levels: findings from the Icatibant Outcome Survey Registry Study.

An Bras Dermatol 2022 May 30. Epub 2022 May 30.

Takeda Distribuidora Ltda, São Paulo, SP, Brazil.

Background: Hereditary angioedema can be caused by C1-Inhibitor (C1-INH) deficiency and/or dysfunction (HAE-1/2) or can occur in patients with normal C1-INH (HAE nC1-INH).

Methods: The Icatibant Outcome Survey (IOS; NCT01034969) registry monitors the safety and effectiveness of icatibant for treating acute angioedema.

Objective: Present findings from Brazilian patients with HAE-1/2 and HAE nC1-INH participating in IOS. Read More

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Dermal Fillers and COVID-19: Angioedema With Urticaria in a Patient Post COVID-19 Infection.

Gurnam Virdi

Cureus 2022 Apr 25;14(4):e24461. Epub 2022 Apr 25.

Dermatology, Academy of Aesthetic Medicine, Sheffield, GBR.

Hyaluronic acid dermal fillers are a very popular choice for patients wanting to undergo non-invasive facial rejuvenation. Its prevalence is predicted to continue to rise. We report a case of delayed angioedema and associated urticaria to hyaluronic acid dermal fillers post COVID-19 infection. Read More

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Benefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Genes (Basel) 2022 May 22;13(5). Epub 2022 May 22.

Pharmacoepidemiology and Statistics Research Center (PESRC), Chiang Mai University, Chiang Mai 50200, Thailand.

Background: Hereditary angioedema (HAE) is a rare genetic disease that can lead to potentially life-threatening airway attacks. Although novel therapies for HAE treatment have become available over the past decades, a comparison of all available treatments has not yet been conducted. As such, we will perform a systematic review and network meta-analysis to identify the best evidence-based treatments for the management of acute attacks and prophylaxis of HAE. Read More

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Inflammatory immune-mediated adverse reactions induced by COVID-19 vaccines in previously injected patients with soft tissue fillers: A case series of 20 patients.

J Cosmet Dermatol 2022 May 27. Epub 2022 May 27.

Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.

Background: Adverse events (AE) after COVID-19 vaccines, particularly, but not solely, with those messenger RNA (mRNA)-based vaccines, have rarely been reported in patients previously treated with dermal fillers (DF).

Objective: To evaluate the morphology, clinical characteristics, the timing of presentation, and outcomes of inflammatory AE appeared in patients injected with DF, after anti-COVID-19 vaccination.

Methods: Descriptive study of a case series of 20 consecutive patients collected after the occurrence of AE in previously filled areas post COVID-19 vaccination. Read More

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Heterogeneity of Drug Allergies and Reaction Lists in Two U.S. Healthcare Systems' Electronic Health Records.

Appl Clin Inform 2022 May 26. Epub 2022 May 26.

Medicine, Brigham and Women's Hospital, Boston, United States.

Background: Healthcare institutions have their own "picklist" for clinicians to document adverse drug reactions (ADRs) into the electronic health record (EHR) allergy list. Whether the lack of a nationally standardized picklist impacts clinician data entries is unknown.

Objectives: To assess the impact of defined reaction picklists on clinical documentation and, therefore, downstream analytics and clinical research using these data at two institutions. Read More

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Autoimmune Neutropenia Associated With HHV-6 Virus Infection: A Case Report.

Front Immunol 2022 9;13:880016. Epub 2022 May 9.

Department of Medicine E, The Chaim Sheba Medical Center, Ramat-Gan, Israel.

Background: Autoimmune neutropenia (AIN) is divided into primary and secondary forms. The former is more prevalent in children and is usually a self-limiting disease. Secondary AIN is more common in adults and often occurs in the setting of another autoimmune disorder or secondary to infections, malignancies or medications. Read More

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Chronic spontaneous urticaria: a low-grade disseminated intravascular coagulation only partially reversed by Omalizumab.

Clin Exp Med 2022 May 25. Epub 2022 May 25.

Department of Medical Sciences and Public Health, and Unit of Internal Medicine, University of Cagliari, Policlinico Universitario - AOU di Cagliari Azienda Ospedaliero Universitaria, SS 554-Bivio Sestu, 09042, Monserrato, CA, Italy.

Chronic spontaneous urticaria (CSU) is a disorder characterized by wheals and/or angioedema. The coagulation cascade and inflammation pathways are closely linked together. The aim of our study was first to investigate the dynamics of clot formation in plasma (Clot Waveform Analysis, CWA) in a group of 47 patients with CSU along with other coagulative parameters dedicated to the study of hypercoagulability, such as D-Dimer, F 1 + 2 peptide, Fibrinogen, Platelet count and Mean Platelet Volume (MPV). Read More

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Facial Angioedema after the first dose of Covishield (adenovirus-vectored severe acute respiratory syndrome coronavirus 2 vaccine): follow-up after the second and third booster doses.

Rev Soc Bras Med Trop 2022 20;55:e00632022. Epub 2022 May 20.

Universidade Federal do Estado do Rio de Janeiro, Hospital Universitário Gaffrée e Guinle, Rio de Janeiro, RJ, Brasil.

Mass vaccination campaigns are essential to control the ongoing novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) pandemic. The Covishield vaccine consists of the replication-deficient simian adenovirus vector ChAdOx1, which contains the full-length structural spike protein of SARS-CoV-2. Occasionally, it can lead to cutaneous reactions that contribute to fear of vaccination, hesitancy, and incomplete vaccination schedules. Read More

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