7,866 results match your criteria Angioedema


Long-term outcomes with subcutaneous C1-inhibitor replacement therapy for prevention of hereditary angioedema attacks.

J Allergy Clin Immunol Pract 2019 Feb 14. Epub 2019 Feb 14.

CSL Behring LLC, King of Prussia, PA, USA.

Background: For the prevention of attacks of hereditary angioedema (HAE), the efficacy and safety of subcutaneous human C1-esterase inhibitor (C1-INH[SC]; HAEGARDA, CSL Behring) was established in the 16-week COMPACT trial.

Objective: To assess the long-term safety, occurrence of angioedema attacks, and use of rescue medication with C1-INH(SC).

Methods: Open-label, randomised, parallel-arm extension of COMPACT across 11 countries. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.054DOI Listing
February 2019

Hemilingual Angioedema after Thrombolysis in a Patient on an Angiotensin II Receptor Blocker.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

Orolingual angioedema (OLAE) is a rare adverse effect of alteplase. Previous studies have associated the occurrence of OLAE with thrombolysed patients maintained on angiotensin converting enzyme inhibitors. We report a case of a 60-year-old male presenting with hyperacute ischemic stroke developing hemilingual edema after thrombolysis. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.030DOI Listing
February 2019

Flexible nasotracheal intubation compared to blind nasotracheal intubation in the setting of simulated angioedema.

Am J Emerg Med 2019 Feb 11. Epub 2019 Feb 11.

Department of Emergency Medicine, Saint Vincent Hospital, Erie, PA, United States of America. Electronic address:

Background: Nasotracheal intubation is rarely performed in the emergency department (ED) but may be required in specific situations such as angioedema. Both blind and flexible nasal intubation (FNI) may be utilized; however, the preferred technique is unknown.

Methods: We performed a randomized, crossover manikin study using a convenience sample of emergency physicians and medical students from a local community teaching hospital. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.02.012DOI Listing
February 2019

Acute Non-Traumatic Spontaneous Auricular Hematoma.

Am J Case Rep 2019 Feb 16;20:204-206. Epub 2019 Feb 16.

Department of Emergency Medicine, Mayo Clinic, Jacksonville, FL, USA.

BACKGROUND Auricular hematomas are well-known among wrestlers and other contact sports participants, but spontaneous auricular hematomas are rare. The differential diagnosis for acute spontaneous auricular swelling is limited. In addition to infectious causes, antecedent trauma, and bleeding complications, angioedema should also be considered. Read More

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http://dx.doi.org/10.12659/AJCR.913464DOI Listing
February 2019

Laryngeal Edema in a Child with Hereditary Angioedema with Normal C1 Inhibitor.

J Allergy Clin Immunol Pract 2019 Feb 12. Epub 2019 Feb 12.

Division of Allergy and Clinical Immunology, Department of Medicine, East Tennessee State University, Johnson City, Tenn. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.01.008DOI Listing
February 2019

Does angioedema influence the quality of life in chronic spontaneous urticaria patients?

Ann Allergy Asthma Immunol 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Diseases, Allergology and Clinical Immunology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland; Department of Internal Diseases and Allergology, Institute of Medicine, University of Opole, Opole, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.01.023DOI Listing
February 2019

Trends in hospitalizations related to anaphylaxis, angioedema and urticaria in the United States.

Ann Allergy Asthma Immunol 2019 Feb 12. Epub 2019 Feb 12.

Division of Pulmonary, Allergy and Critical Care Medicine, Penn State College of Medicine, Hershey, PA.

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http://dx.doi.org/10.1016/j.anai.2019.02.003DOI Listing
February 2019

Idiopathic non-histaminergic angioedema: a single-centre real-life experience from Italy.

Allergy 2019 Feb 11. Epub 2019 Feb 11.

Department of Biomedical Sciences and Human Oncology Unit of Internal Medicine "G. Baccelli", University of Bari Medical School - Aldo Moro, Bari, Italy.

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http://dx.doi.org/10.1111/all.13737DOI Listing
February 2019
1 Read

Abnormal T-cell phenotype in episodic angioedema with hypereosinophilia (Gleich's syndrome): frequency, clinical implication and prognosis.

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Service de Médecine Interne, Université Versailles Saint-Quentin-en-Yvelines, Centre de Référence des Syndromes Hyperéosinophiliques (CEREO), Hôpital Foch, Suresnes, France.

Background: Episodic Angioedema with eosinophilia (EAE, Gleich's syndrome) is a rare disorder consisting of recurrent episodes of angioedema, hypereosinophilia and frequent elevated serum Immunoglobin M.

Methods: We conducted a retrospective multicenter nationwide study regarding the clinical spectrum and therapeutic management of patients with EAE in France.

Results: Thirty patients were included with a median age at diagnosis of 41 years [5-84]. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.001DOI Listing
February 2019
3 Reads

GSK2646264, a spleen tyrosine kinase inhibitor attenuates the release of histamine in ex vivo human skin.

Br J Pharmacol 2019 Feb 8. Epub 2019 Feb 8.

Respiratory TAU, GSK, Gunnels Wood Rd, Stevenage.

Background And Purpose: Chronic Spontaneous Urticaria presents as a heterogeneous syndrome characterised by wheals, angioedema or both for greater than six weeks. Spleen tyrosine kinase (SYK) mediates allergen-induced mast cell degranulation via the IgE signalling pathway, a central component of wheal formation and inflammation. In this study, we demonstrate that perfused or topically administered GSK2646264 dose dependently attenuates IgE-mediated histamine release from mast cells in an ex vivo human skin model. Read More

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http://dx.doi.org/10.1111/bph.14610DOI Listing
February 2019
1 Read

Hereditary angioedema: Repeated attacks in a 10-year-old boy.

Pediatr Int 2019 Jan;61(1):101-103

Department of Pediatrics, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.

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http://dx.doi.org/10.1111/ped.13729DOI Listing
January 2019
1 Read

Diagnosis and management of drug-induced anaphylaxis in children: an EAACI position paper.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Geneva University Hospitals, Department of child and adolescent, Pediatric Allergy Unit, Geneva, Switzerland.

Drug hypersensitivity reactions (DHR) constitute a major and common public health problem, particularly in children. One of the most severe manifestations of DHR is anaphylaxis, which might be associated with a life-threatening risk. During those past decades, anaphylaxis has received particularly a lot of attention and international consensus guidelines have been recently published. Read More

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http://dx.doi.org/10.1111/pai.13034DOI Listing
February 2019
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A Forgotten Cause of Allergy at ER That Is Still Difficult to Diagnose and Treat at Poor Resource Setting: Angioedema after Using Angiotensin Converting Enzyme Inhibitors for 4 Years.

Case Reports Immunol 2019 2;2019:1676391. Epub 2019 Jan 2.

North Colombo Teaching Hospital, Ragama, Sri Lanka.

Angiotensin converting enzyme inhibitors (ACEi) are the most commonly used antihypertensives. Therefore, ACEI induced angioedema (ACEi-AE) is not uncommon. Physicians tend to miss the diagnosis whenever a patient is taking the drug for years due to misbelief of "a drug that was taken for years may not be the cause for an allergic reaction or an angioedema". Read More

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http://dx.doi.org/10.1155/2019/1676391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339731PMC
January 2019
1 Read

Allergic Reactions Captured by Voluntary Reporting.

J Patient Saf 2019 Jan 31. Epub 2019 Jan 31.

Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital and the Massachusetts General Professional Organization.

Background: The epidemiology of hospital adverse reactions (ARs), particularly allergic reactions, or hypersensitivity reactions (HSRs), is poorly defined. To determine priorities for allergy safety in healthcare, we identified and described safety reports of allergic reactions.

Methods: We searched the safety report database of a large academic medical center from April 2006 to March 2016 using 101 complete, truncated, and/or misspelled key words related to allergic symptoms, treatments, and culprits (e. Read More

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http://dx.doi.org/10.1097/PTS.0000000000000568DOI Listing
January 2019
1 Read

C1-INH concentrate for prophylaxis during pregnancy in hereditary angioedema with normal C1-INH.

J Allergy Clin Immunol Pract 2019 Feb;7(2):754

Allergy/Immunology Associates Inc, Mayfield Heights, Ohio.

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http://dx.doi.org/10.1016/j.jaip.2018.10.056DOI Listing
February 2019
1 Read

Is hereditary angioedema related to an increased risk of atherosclerosis?

Ann Allergy Asthma Immunol 2019 Feb;122(2):228-229

Department of Medical Sciences and Public Health, Unit of Internal Medicine, Allergy and Clinical Immunology, University of Cagliari, Italy.

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http://dx.doi.org/10.1016/j.anai.2018.11.006DOI Listing
February 2019
1 Read

[Correct recognition and treatment of angioedema].

Hautarzt 2019 Feb;70(2):82-83

Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

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http://dx.doi.org/10.1007/s00105-018-4340-1DOI Listing
February 2019
1 Read

Psychometric properties of the Spanish version of the once-daily Urticaria Activity Score (UAS) in patients with chronic spontaneous urticaria managed in clinical practice (the EVALUAS study).

Health Qual Life Outcomes 2019 Jan 31;17(1):23. Epub 2019 Jan 31.

Allergy Unit, Pneumology Department, Hospital Clinic, University of Barcelona, Barcelona, Spain.

Background: The daily diary Urticaria Activity Score (UAS) and its weekly score (UAS7) are widely used to assess signs and symptoms in patients with chronic spontaneous urticaria (CSU). The objective of this study was to assess the psychometric properties of a Spanish version of the once-daily UAS.

Methods: Observational study in patients ≥18 years old receiving usual care for CSU (daily or almost daily occurrence of generalized hives or angioedema for ≥6 weeks). Read More

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http://dx.doi.org/10.1186/s12955-019-1087-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357477PMC
January 2019
1 Read

Recurrent urinary tract infections in kidney transplant recipients during the first-year influence long-term graft function: a single-center retrospective cohort study.

J Nephrol 2019 Jan 30. Epub 2019 Jan 30.

Department of Emergency and Organ Transplantation, Nephrology, Dialysis and Transplantation Unit, University of Bari, Bari, Italy.

Urinary tract infections (UTIs) after kidney transplantation are associated with significant morbidity. However, data on the impact of UTI on graft survival are controversial. We conducted a retrospective cohort study of 380 kidney transplant patients. Read More

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http://dx.doi.org/10.1007/s40620-019-00591-5DOI Listing
January 2019
1 Read

The burden of chronic spontaneous urticaria: unsatisfactory treatment and healthcare resource utilization in France (the ASSURE-CSU study).

Eur J Dermatol 2018 Dec;28(6):795-802

Hospices civils de Lyon, Claude-Bernard University, Lyon, France.

Data on the clinical burden of chronic spontaneous urticaria (CSU) and economic consequences are lacking in France. To characterize the clinical and economic burden of CSU in symptomatic patients despite treatment by analysing data of French patients from the ASSURE-CSU study. ASSURE-CSU was an international observational study that included CSU patients with symptoms that lasted for 12 months or more despite treatment. Read More

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http://dx.doi.org/10.1684/ejd.2018.3446DOI Listing
December 2018
1 Read

Cost-Effectiveness of Prophylactic Medications for the Treatment of Hereditary Angioedema Due to C1 Inhibitor Deficiency: A Real-World U.S. Perspective.

Authors:
Bruce L Zuraw

J Manag Care Spec Pharm 2019 Feb;25(2):148-151

1 Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego School of Medicine and Medicine Service, San Diego VA Healthcare.

Disclosures: No funding supported the writing of this commentary. The author reports personal fees from BioCryst, CSL Behring, Shire, and Pharming and grants from Ionis. He is chair of the US HAEA Medical Advisory Board and scientific advisor for HAE International. Read More

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http://dx.doi.org/10.18553/jmcp.2019.25.2.148DOI Listing
February 2019
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The Effectiveness and Value of Lanadelumab and C1 Esterase Inhibitors for Prophylaxis of Hereditary Angioedema Attacks.

J Manag Care Spec Pharm 2019 Feb;25(2):143-148

1 Institute for Clinical and Economic Review, Boston, Massachusetts.

Disclosures: Funding for this summary was contributed by the Laura and John Arnold Foundation, Blue Shield of California, and California Health Care Foundation to the Institute for Clinical and Economic Review (ICER), an independent organization that evaluates the evidence on the value of health care interventions. ICER's annual policy summit is supported by dues from Aetna, AHIP Anthem, Blue Shield of California, CVS Caremark, Express Scripts, Harvard Pilgrim Health Care, Cambia Health Solutions, United Healthcare, Kaiser Permanente, Premera Blue Cross, AstraZeneca, Genentech, GlaxoSmithKline, Johnson & Johnson, Merck, National Pharmaceutical Council, Prime Therapeutics, Sanofi, Spark Therapeutics, Health Care Service Corporation, Editas, Alnylam, Regeneron, Mallinkrodt, Biogen, HealthPartners, and Novartis. Agboola, Dreitlein, and Pearson are ICER employees. Read More

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http://dx.doi.org/10.18553/jmcp.2019.25.2.143DOI Listing
February 2019
1 Read

Angioedema after thrombolysis with tissue plasminogen activator: an airway emergency.

Oxf Med Case Reports 2019 Jan 24;2019(1):omy112. Epub 2019 Jan 24.

Department of Emergency Medicine, The Brody School of Medicine at East Carolina University, Greenville, NC, USA.

Recombinant tissue plasminogen activator (rtPA), an enzyme that catalyzes the conversion of plasminogen to plasmin resulting in fibrinolysis, is used for the treatment of acute ischemic strokes. The use of this medication is not without complication. One complication of this therapy is angioedema. Read More

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http://dx.doi.org/10.1093/omcr/omy112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345090PMC
January 2019
1 Read

Oxidative stress markers in patients with hereditary angioedema.

Arch Med Sci 2019 01 31;15(1):92-98. Epub 2017 Jul 31.

School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Introduction: Hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) or with normal C1-INH is characterized by recurrent swellings due to uncontrolled production of vasoactive mediators, among which bradykinin (BK) is crucial. Through the binding and activation of the two human BK-receptors, kinins may have dual beneficial and deleterious effects in vascular and inflammation physiopathology by inducing oxidative stress. We aimed to assess the serum concentrations of advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) in patients affected by HAE. Read More

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http://dx.doi.org/10.5114/aoms.2017.66160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348350PMC
January 2019
1 Read

Incidental Pharmacogenetics Findings in an HLA-related Research: Considerations for Primary Prevention.

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia.

Hypersensitivity drug reactions (HDRs) are an immense public health problem where significant proportions may lead to mortality. HDRs can manifest in various phenotypes, mainly cutaneous reactions that range from the mild; i.e. Read More

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http://dx.doi.org/10.1111/cea.13347DOI Listing
January 2019
8 Reads
4.769 Impact Factor

Delayed Diagnosis of Hereditary Angioedema with C1-inhibitor Deficiency in Iranian Children and Adolescents.

Pediatr Allergy Immunol 2019 Jan 28. Epub 2019 Jan 28.

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Hereditary angioedema is an autosomal dominant deficiency of C1-inhibitor (C1-INH-HAE). This rare but potentially fatal disease gives rise to episodes of bradykinin-mediated edema in face, trunk, extremities, genitalia, gastrointestinal tract and upper airway. This leads to severe outcomes including asphyxiation, unnecessary emergency abdominal surgeries, and a considerably diminished quality of life in addition to high economic burden for the health care system. Read More

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http://doi.wiley.com/10.1111/pai.13028
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http://dx.doi.org/10.1111/pai.13028DOI Listing
January 2019
2 Reads
3.397 Impact Factor

Angiopoietin-1 haploinsufficiency affects the endothelial barrier and causes hereditary angioedema.

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Backgound: Different mutations of the angiopoietin-1 gene (ANGPT1) have been associated with the occurrence of Hereditary Angioedema (HAE).

Objective: The purpose of the study is to clarify whether the ANGPT1 A119S variant plays its role via haploinsufficiency or a dominant negative effect.

Methods: The ability of ANGPT1 A119S variant to affect the endothelial barrier function was assessed by immunocytochemistry. Read More

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http://dx.doi.org/10.1111/cea.13349DOI Listing
January 2019
1 Read

SERPING1 exon 3 splicing variants using alternative acceptor splice sites.

Mol Immunol 2019 Mar 24;107:91-96. Epub 2019 Jan 24.

Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic; Department of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Mutations in the C1 inhibitor (C1INH) encoding gene, SERPING1, are associated with hereditary angioedema (HAE) which manifests as recurrent submucosal and subcutaneous edema episodes. The major C1INH function is the complement system inhibition, preventing its spontaneous activation. The presented study is focused on SERPING1 exon 3, an alternative and extraordinarily long exon (499 bp). Read More

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http://dx.doi.org/10.1016/j.molimm.2019.01.007DOI Listing
March 2019
2 Reads

Fixed-Dose Subcutaneous C1-Inhibitor Liquid for Prophylactic Treatment of C1-INH-HAE: SAHARA Randomized Study.

J Allergy Clin Immunol Pract 2019 Jan 22. Epub 2019 Jan 22.

Hungarian Angioedema Reference Center, Semmelweis University, Budapest, Hungary.

Background: Hereditary angioedema (HAE) with C1 inhibitor deficiency (C1-INH) is characterized by swelling of subcutaneous and/or submucosal tissues.

Objective: To evaluate efficacy/ safety of fixed-dose subcutaneous plasma-derived C1-INH (pdC1-INH) liquid for HAE attack prevention (NCT02584959).

Methods: Eligible patients were ≥12 years with ≥2 monthly attacks prescreening or pre-long-term prophylaxis. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.021DOI Listing
January 2019
4 Reads

Progesterone hypersensitivity: Case report with favorable evolution.

Exp Ther Med 2019 Feb 5;17(2):1125-1127. Epub 2018 Dec 5.

Department of Psychiatry, Clinical Hospital of Psychiatry 'Al. Obregia', 041914 Bucharest, Romania.

Progesterone hypersensitivity or autoimmune progesterone dermatitis is characterized by heterogeneous skin eruptions that cyclically aggravate during the second half of the menstrual cycle, corresponding to a rise in the progesterone level. Clinical presentation is highly variable and includes all urticaria manifestations with or without angioedema, vesiculobullous, eczematous, purpuric or target-like lesions on the skin and mucous membrane. Both endogenous progesterone as well as exogenous progestogens may represent an initial trigger. Read More

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http://dx.doi.org/10.3892/etm.2018.7055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327669PMC
February 2019
1 Read

Isolated angioedema: An overview of clinical features and etiology.

Exp Ther Med 2019 Feb 16;17(2):1068-1072. Epub 2018 Nov 16.

Allergology and Immunology Discipline, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania.

Angioedema can occur in isolation, accompanied by urticaria, or as a feature of anaphylaxis in mast cell-mediated disorders, bradykinin-mediated disorders, as well as in others with unknown mechanisms, such as infections, rare disorders, or idiopathic angioedema. In mast cell-mediated angioedema, other signs and symptoms of mast cell-mediator release are frequently seen. However, clear evidence of mast cell degranulation may be absent in histaminergic angioedema. Read More

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http://dx.doi.org/10.3892/etm.2018.6982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327642PMC
February 2019
1 Read

Dipeptidyl peptidase IV Inhibitory activity of Terminalia arjuna attributes to its cardioprotective effects in experimental diabetes: In silico, in vitro and in vivo analyses.

Phytomedicine 2018 Sep 19;57:158-165. Epub 2018 Sep 19.

Department of Pathology, MGM Medical College, Navi Mumbai, India.

Background: The marketed synthetic (Dipeptidyl peptidase-IV) DPP-IV Inhibitors are expensive antidiabetic drugs and have been reported to cause unacceptable adverse effects such as pancreatitis, angioedema, thyroid and pancreatic cancers. In this scenario research to develop novel DPP-IV Inhibitors from alternative sources is the need of the hour.

Hypothesis/purpose: Terminalia arjuna, a medicinal herb with antidiabetic and cardioprotective activities may represent a natural DPP-IV Inhibitor, the DPP-IV Inhibitory activity of which may translate into demonstrable therapeutic benefits in setting of diabetes with cardiovascular co-morbidities. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.09.195DOI Listing
September 2018
2 Reads

Eicosanoid mediator profiles in different phenotypes of nonsteroidal anti-inflammatory drug-induced urticarial.

Allergy 2019 Jan 22. Epub 2019 Jan 22.

ARADyAL Network RD16/0006/0001, Carlos III Health Institute, Madrid, Spain.

Background: The role of arachidonic acid metabolites in NSAID-induced hypersensitivity has been studied in depth for NSAID-exacerbated respiratory disease (NERD) and NSAID-exacerbated cutaneous disease (NECD). However, no information is available for NSAID-induced urticarial/angioedema (NIUA), despite it being the most frequent clinical entity induced by NSAID hypersensitivity. We evaluated changes in leukotriene and prostaglandin metabolites for NIUA patients, using patients with NECD and single-NSAID-induced urticaria/angioedema or anaphylaxis (SNIUAA) for comparison. Read More

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http://doi.wiley.com/10.1111/all.13725
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http://dx.doi.org/10.1111/all.13725DOI Listing
January 2019
8 Reads

Eperisone-Induced Anaphylaxis: Pharmacovigilance Data and Results of Allergy Testing.

Allergy Asthma Immunol Res 2019 Mar;11(2):231-240

Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Eperisone is an oral muscle relaxant used in musculoskeletal disorders causing muscle spasm and pain. For more effective pain control, eperisone is usually prescribed together with nonsteroidal anti-inflammatory drugs (NSAIDs). As such, eperisone may have been overlooked as the cause of anaphylaxis compared with NSAIDs. Read More

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http://dx.doi.org/10.4168/aair.2019.11.2.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340802PMC
March 2019
2 Reads

Successful treatment of normocomplementemic urticarial vasculitis with omalizumab: A report of three cases and literature review.

Asian Pac J Allergy Immunol 2019 Jan 13. Epub 2019 Jan 13.

Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Urticarial vasculitis (UV) is a rare form of cutaneous leukocytoclastic vasculitis with persistent urticarial lesions. UV may be severe and refractory to standard treatment including antihistamines, anti-inflammatories, antimalarials, corticosteroids and immunosuppressants. Omalizumab, an anti-IgE antibody, is approved for chronic spontaneous urticaria. Read More

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http://dx.doi.org/10.12932/AP-050918-0402DOI Listing
January 2019
5 Reads

Hypersensitivity Reactions in Serious Adverse Events Reported for Paracetamol in the EudraVigilance Database, 2007⁻2018.

Pharmacy (Basel) 2019 Jan 17;7(1). Epub 2019 Jan 17.

Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, 31-531 Krakow, Poland.

Paracetamol is a popular and easily available drug which is used world-wide as analgesic, antipyretic agent. Hypersensitivity reactions to this drug involve a wide range of symptoms of various importance for patient management. The EudraVigilance (EV) database serves as a system for monitoring adverse events (AE) due to drug intake. Read More

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http://dx.doi.org/10.3390/pharmacy7010012DOI Listing
January 2019
4 Reads

[Angioedema prophylaxis].

Authors:
V Zampeli M Magerl

Hautarzt 2019 Feb;70(2):107-115

Klinik für Dermatologie, Venerologie und Allergologie, Allergie-Centrum-Charité/ECARF, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Angioedema is a spontaneous, edematous swelling of the deep layers of the skin or mucous membrane. Angioedema in the respiratory tract is potentially life-threatening. The classification of angioedema into mast-cell-mediated (e. Read More

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http://link.springer.com/10.1007/s00105-018-4345-9
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http://dx.doi.org/10.1007/s00105-018-4345-9DOI Listing
February 2019
5 Reads

[Age-specific aspects in the treatment of angioedema patients].

Authors:
P Staubach

Hautarzt 2019 Feb;70(2):101-106

Spezialsprechstunde Angioödeme, Hautklinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.

Manifestation of angioedema can occur at any age. We distinguish between two main subtypes: mast cell mediator-associated angioedema (often with hives) and the non-mast cell mediator-associated angioedema. The patient's history is very important due to the fact that one subtype can be hereditary, but we also have to consider new mutations and even not yet diagnosed patients. Read More

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http://dx.doi.org/10.1007/s00105-018-4346-8DOI Listing
February 2019
1 Read

Hereditary angioedema: Linking complement regulation to the coagulation system.

Res Pract Thromb Haemost 2019 Jan 16;3(1):38-43. Epub 2018 Dec 16.

Department of Molecular Cell Biology Sanquin Research & Landsteiner Laboratory Amsterdam The Netherlands.

Congenital deficiency of C1 inhibitor, the main inhibitor of the classic complement system pathway, leads to paroxysmal angioedema (hereditary angioedema) that can be debilitating or life-threatening for affected patients. In the past few years many new insights on the pathogenesis of angioedema formation in the presence of low levels of C1 inhibitor has been accumulated. There is a central role for bradykinin that is released upon activation of the kallikrein-kinin system that is insufficiently controlled by adequate levels of C1 inhibitor. Read More

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http://doi.wiley.com/10.1002/rth2.12175
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http://dx.doi.org/10.1002/rth2.12175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332742PMC
January 2019
7 Reads

Discovery of TD-0212, an Orally Active Dual Pharmacology AT Antagonist and Neprilysin Inhibitor (ARNI).

ACS Med Chem Lett 2019 Jan 3;10(1):86-91. Epub 2018 Dec 3.

Theravance Biopharma US Inc., 901 Gateway Boulevard, South San Francisco, California 94080, United States.

Dual inhibition of angiotensin-converting enzyme (ACE) and neprilysin (NEP) by drugs such as omapatrilat produces superior antihypertensive efficacy relative to ACE inhibitors but is associated with a higher risk of life-threatening angioedema due to bradykinin elevations. We hypothesized that dual AT (angiotensin II type 1 receptor) blockade and NEP inhibition with a single molecule would produce similar antihypertensive efficacy to omapatrilat without the risk of angioedema since ACE (the rate limiting enzyme in bradykinin metabolism) would remain uninhibited. Merging the structures of losartan (an AT antagonist) and thiorphan (a NEP inhibitor) led to the discovery of a novel series of orally active, dual AT antagonist/NEP inhibitors (ARNIs) exemplified by compound (TD-0212). Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331171PMC
January 2019
1 Read

Cutaneous adverse drug reactions: A four-year audit from a district hospital in Johor, Malaysia.

Authors:
H S Kim M M Tang

Med J Malaysia 2018 Dec;73(6):397-399

Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Cutaneous adverse drug reactions (cADR) are common. However, only very few audits reported the clinical characteristics of cADR captured at district hospitals. We performed a 4-year audit on cADR reported to the Department of Pharmacy in Hospital Pakar Sultanah Fatimah between May 2012 and March 2016. Read More

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December 2018
1 Read

Swollen Lips After a Night of Partying-An Allergic Reaction to Ecstasy?

J Forensic Sci 2019 Jan 15. Epub 2019 Jan 15.

Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Butenfeld 34, 22529, Hamburg, Germany.

Ecstasy (MDMA) is a mood-lifting drug with numerous somatic side effects, for example, dehydration or continuous chewing and biting. We describe the case of a young woman who underwent a forensic medical examination for suspected sexual assault. She claimed to have suffered from a memory lapse, and she had a painful swelling of her lips with a plaque-like coating on her lips and buccal mucosa. Read More

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http://dx.doi.org/10.1111/1556-4029.13999DOI Listing
January 2019
2 Reads

Relationship between Chronic urticaria and autoimmune thyroid disease.

J Adv Pharm Technol Res 2018 Oct-Dec;9(4):158-161

Department of Endocrine, Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Hives is an erythematous and itchy disease that commonly affects the trunk and the organs. Acute urticaria is a common disease and affects about 10%-20% of the population during its lifetime. In patients with chronic urticaria, about 25%-30% of cases, antithyroid peroxidase (TPO) was detected and Hashimoto's disease was diagnosed. Read More

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http://dx.doi.org/10.4103/japtr.JAPTR_342_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302681PMC
January 2019
1 Read

C-reactive protein (CRP) rs3093059C predicts poor mizolastine response in chronic spontaneous urticaria patients with elevated serum CRP level.

Exp Dermatol 2019 Jan 11. Epub 2019 Jan 11.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Chronic spontaneous urticaria (CSU) is a frequent disorder with recurrent itchy wheals and/or angioedema, and nearly 35% patients respond poorly to non-sedating H1 antihistamine treatment. CRP gene encodes the C-reactive protein, which is involved in the pathogenesis of CSU. To investigate the impacts of CRP polymorphisms on the susceptibility and therapeutic efficacy in the South Han CSU patients, we enrolled 145 CSU patients in our study. Read More

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http://doi.wiley.com/10.1111/exd.13874
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http://dx.doi.org/10.1111/exd.13874DOI Listing
January 2019
5 Reads
3.762 Impact Factor

Angioedema; An Unreported Adverse Effect Of Pitavastatin.

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(4):603-604

Cardiology Department, Chippenham Hospital, Richmond VA, USA.

Angioedema is a life-threatening reaction characterized by swelling of the face, lips, tongue or larynx. Known adverse effects of Pitavastatin do not include angioedema. We report first case of a 55-year-old Asian male developing post exposure angioedema to 2 mg Pitavastatin. Read More

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January 2019
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[Gender aspects in angioedema].

Hautarzt 2019 Feb;70(2):92-100

Klinik für Dermatologie, Allergologie und Venerologie, Comprehensive Allergy Center (CAC), Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Background: Angioedema can be triggered by mediators bradykinin or histamine. Gender-specific differences and potential biomarkers for follow-up/therapy monitoring are mostly unknown.

Objectives: To what extent are gender-related defects, prodromes, trigger factors, clinical parameters such as number of attacks, frequency, localization, laboratory values, hormones and response to therapy different for the variant types of angioedema. Read More

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http://link.springer.com/10.1007/s00105-018-4347-7
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http://dx.doi.org/10.1007/s00105-018-4347-7DOI Listing
February 2019
3 Reads

Melkersson-Rosenthal syndrome: a case report of a rare disease with overlapping features.

Allergy Asthma Clin Immunol 2019 5;15. Epub 2019 Jan 5.

2Department of Neuroscience, Division of Dentistry, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-018-0316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320604PMC
January 2019
5 Reads

Diagnosis of solitary extramedullary plasmacytoma located in the nasopharynx in a patient with acquired angioedema.

Postepy Dermatol Alergol 2018 Dec 13;35(6):636-637. Epub 2018 Nov 13.

Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.

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http://dx.doi.org/10.5114/ada.2018.77616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320481PMC
December 2018
1 Read