Search our Database of Scientific Publications and Authors

I’m looking for a

    7419 results match your criteria Angioedema

    1 OF 149

    Clinicoepidemiologic Features of Chronic Urticaria in Patients with versus without Subclinical Helicobacter pylori Infection: A Cross-Sectional Study of 150 Patients.
    Int Arch Allergy Immunol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Dermatology, Venereology and Leprosy, Dr. R.P. Govt. Medical College, Kangra, India.
    Background: The Helicobacter pylori infection is linked to chronic urticaria in nearly 60% of patients. We studied clinicoepidemiologic features in patients with chronic urticaria with and without H. pylori infection. Read More

    Intermittent C1-Inhibitor Deficiency Associated with Recessive Inheritance: Functional and Structural Insight.
    Sci Rep 2018 Jan 17;8(1):977. Epub 2018 Jan 17.
    "L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan, via GB Grassi 74, 20157, Milan, Italy.
    C1-inhibitor is a serine protease inhibitor (serpin) controlling complement and contact system activation. Gene mutations result in reduced C1-inhibitor functional plasma level causing hereditary angioedema, a life-threatening disorder. Despite a stable defect, the clinical expression of hereditary angioedema is unpredictable, and the molecular mechanism underlying this variability remains undisclosed. Read More

    [Allergology and clinical immunology].
    Rev Med Suisse 2018 Jan;14(588-589):15-18
    Service d'immunologie et d'allergologie, Département des spécialités de médecine, HUG, 1211 Genève 14.
    Hereditary angioedema (HA) is a disabling and potentially fatal condition. The management of HA includes treatment of acute attacks, short-term prophylaxis to prevent an attack, and long-term prophylaxis to minimize the frequency and severity of recurrent attacks. In this article, we will present new therapeutic alternatives for long term prophylaxis. Read More

    Executive summary: Methods and evidence report for the evidence - and consensus- based (S3) Guideline for the definition, classification, diagnosis, and management of urticaria - revision and update 2017.
    Allergy 2018 Jan 16. Epub 2018 Jan 16.
    Department of Dermatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health.
    For the revision and update of the EAACI/GA²LEN/EDF/WAO guideline on urticaria we defined and followed a structured process as recommended by national and international guideline development manuals (1) and took the Appraisal of Guidelines Research and Evaluation (AGREE II) Instrument (2) into account. The full methods report can be found in the online appendix [please add link]. This article is protected by copyright. Read More

    The EAACI/GA²LEN/EDF/WAO Guideline for the Definition, Classification, Diagnosis and Management of Urticaria. The 2017 Revision and Update.
    Allergy 2018 Jan 15. Epub 2018 Jan 15.
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy-Centre-Charité.
    This evidence and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on December 1st, 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies. Read More

    The urgent need for a harmonized severity scoring system for acute allergic reactions.
    Allergy 2018 Jan 13. Epub 2018 Jan 13.
    NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
    The accurate assessment and communication of the severity of acute allergic reactions is important to patients, clinicians, researchers, the food industry, public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. Read More

    Perioperative Management of a Patient with Cold Urticaria.
    Front Med (Lausanne) 2017 18;4:222. Epub 2017 Dec 18.
    Department of Anesthesiology, OSU Wexner Medical Center, Columbus, OH, United States.
    Cold urticaria consists of an allergic immune response to cold temperatures with symptoms ranging from pruritic wheals to life-threatening angioedema, bronchospasm, or anaphylactic shock. Adequate planning to maintain normothermia perioperatively is vital due to impaired hypothalamic thermoregulation and overall depression of sympathetic outflow during deep sedation and general anesthesia. This case report describes the successful perioperative management of a 45-year-old female with a history of cold urticaria undergoing a laparoscopic Nissen fundoplication for refractory gastroesophageal reflux disease and discusses how to appropriately optimize the care of these patients. Read More

    Acute dystonic reaction leading to lingual hematoma mimicking angioedema.
    Indian J Pharmacol 2017 Jul-Aug;49(4):325-327
    Department of Otorhinolaryngology, Gulhane Training and Research Hospital, Ankara, Turkey.
    Lingual hematoma is a severe situation, which is rare and endangers the airway. It can develop due to trauma, vascular abnormalities, and coagulopathy. Due to its sudden development, it can be clinically confused with angioedema. Read More

    The international WAO/EAACI guideline for the management of hereditary angioedema - the 2017 revision and update.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Department of Medicine and Pediatrics, Penn State University, Hershey, PA, USA.
    Hereditary angioedema (HAE) is a rare disease and a serious health problem, globally and for affected patients and their families. The pathophysiological background is primarily a vascular reaction to an overshooting local production of bradykinin. Evidence-based recommendations are needed to inform and guide clinical decision makers. Read More

    Exposure-Response Model of Subcutaneous C1-Inhibitor Concentrate to Estimate the Risk of Attacks in Patients With Hereditary Angioedema.
    CPT Pharmacometrics Syst Pharmacol 2018 Jan 9. Epub 2018 Jan 9.
    Clinical Pharmacology and Early Development, CSL Limited, Parkville, Australia.
    Subcutaneous C1-inhibitor (HAEGARDA, CSL Behring), is a US Food and Drug Administration (FDA)-approved, highly concentrated formulation of a plasma-derived C1-esterase inhibitor (C1-INH), which, in the phase III Clinical Studies for Optimal Management in Preventing Angioedema with Low-Volume Subcutaneous C1-inhibitor Replacement Therapy (COMPACT) trial, reduced the incidence of hereditary angioedema (HAE) attacks when given prophylactically. Data from the COMPACT trial were used to develop a repeated time-to-event model to characterize the timing and frequency of HAE attacks as a function of C1-INH activity, and then develop an exposure-response model to assess the relationship between C1-INH functional activity levels (C1-INH(f)) and the risk of an attack. The C1-INH(f) values of 33. Read More

    In chronic spontaneous urticaria, IgE against staphylococcal enterotoxins is common and functional.
    Allergy 2018 Jan 9. Epub 2018 Jan 9.
    Charité - Universitätsmedizin Berlin, Department of Dermatology and Allergology, Berlin, Germany.
    Background: Chronic spontaneous urticaria (CSU) is a frequent disorder with recurrent itchy wheals and/or angioedema. Despite the known effectiveness of omalizumab therapy, the relevant IgE antigens are largely unknown. Recently, increased rates of elevated levels of IgE towards Staphylococcus aureus enterotoxins (SEs) were described in CSU. Read More

    Inhalant allergen sensitization is an independent risk factor for the development of angioedema.
    Am J Otolaryngol 2017 Dec 27. Epub 2017 Dec 27.
    Department of Otolaryngology - Head and Neck Surgery, Boston University School of Medicine, Boston, MA 02118, United States. Electronic address:
    Background/objective: The etiology and risk factors for angioedema remain poorly understood with causative triggers often going undiagnosed despite repeated reactions. The purpose of this study was to determine the relationship between inhalant allergen sensitization and angioedema.

    Methods: A retrospective review of patients who had in vitro inhalant allergy testing from 2006 to 2010 was performed. Read More

    [Vulvar angioedema during pregnancy].
    Ned Tijdschr Geneeskd 2018 ;162(0):D1548
    Deventer Ziekenhuis, Deventer.
    Background: Angioedema is a condition of acute and extensive fluid accumulation in skin or mucosae due to increased blood vessel permeability. Angioedema can have several causes, including pregnancy.

    Case Description: A healthy 33-year-old pregnant woman had acute, substantial swelling of the labia minora with no other symptoms. Read More

    Catamenial anaphylaxis: a woman under monthly progesterone curse.
    BMJ Case Rep 2018 Jan 4;2018. Epub 2018 Jan 4.
    Pulmonary Department and MICU, The Brooklyn Hospital Center, Brooklyn, New York, USA.
    Catamenial or cyclical anaphylaxis is a complex clinical syndrome with poorly reported incidence and prevalence in the literature review. The underlying mechanism is still a myth although a few proposed hypotheses are stated. Early recognition of these symptoms will bring optimal treatment and prevent unnecessary intubation and complications. Read More

    Cause and Clinical Presentation of Anaphylaxis in Singapore: From Infancy to Old Age.
    Int Arch Allergy Immunol 2018 Jan 5. Epub 2018 Jan 5.
    Department of Allergy and Immunology, KK Women's and Children's Hospital, Singapore, Singapore.
    Background: The study objective was to compare age-related differences in the cause and clinical presentation of anaphylaxis.

    Methods: We conducted a prospective study of patients visiting the emergency department for anaphylaxis. Data were collected from 3 emergency departments from 1 April 2014 to 31 December 2015. Read More

    Evaluating satisfaction of patients with hereditary angioedema with their past and present treatments: Implications for future therapies.
    Allergy Asthma Proc 2018 Jan;39(1):74-80
    Background: Ever-expanding armamentarium of treatments for hereditary angioedema (HAE) are associated with various adverse effects, issues with vascular access, or lack of self-administration.

    Objective: To understand patients' impressions and confidence in their past and present treatments, and identifying adverse events while also directly asking patients to reveal their hope for the future of HAE management and treatments.

    Methods: After institutional review board approval, all subjects with laboratory-confirmed HAE were mailed a survey that they completed and returned to the researchers, and data were collected and entered into a secure online web application for surveys. Read More

    Hypovolemic Shock Caused by Angiotensin-Converting Enzyme Inhibitor-Induced Visceral Angioedema: A Case Series and A Simple Method to Diagnose this Complication in the Emergency Department.
    J Emerg Med 2017 Dec 18. Epub 2017 Dec 18.
    Department of Emergency Medicine, Palmetto Health Richland Hospital, Columbia, South Carolina.
    Background: Visceral angioedema is a rarely reported side effect of angiotensin-converting-enzyme inhibitors (ACEI). Because signs and symptoms tend to be nonspecific, the diagnosis is difficult to make, especially in the emergency department (ED).

    Case Report: We describe 2 patients presenting with signs of hypovolemic shock, in which the diagnosis of ACEI-induced visceral angioedema was made in the ED. Read More

    Anaphylactic Reactions After Discontinuation of Hymenoptera Venom Immunotherapy: A Clonal Mast Cell Disorder Should Be Suspected.
    J Allergy Clin Immunol Pract 2017 Dec 16. Epub 2017 Dec 16.
    Allergy and Respiratory Diseases, IRCCS San Martino IST, University of Genoa, Genoa, Italy. Electronic address:
    Background: Up to 75% of patients with severe anaphylactic reactions after Hymenoptera sting are at risk of further severe reactions if re-stung. Venom immunotherapy (VIT) is highly effective in protecting individuals with ascertained Hymenoptera venom allergy (HVA) and previous severe reactions. After a 3- to 5-year VIT course, most patients remain protected after VIT discontinuation. Read More

    [Medicaments and oral healthcare 6. Oral side effects of -medications commonly used by older people].
    Ned Tijdschr Tandheelkd 2017 Dec;124(12):645-652
    In the coming decades the western world will experience a double ageing of its population; there will be an increase in both the number of older people and the average age. The increase in life expectancy will also mean more and more older people who suffer from multiple systemic diseases that are treated with medications. At this moment, 45% of those over 65 use 5 or more medications and 20% of those over 75 use as many as 10 or more. Read More

    Disease Severity, Activity, Impact, and Control and How to Assess Them in Patients with Hereditary Angioedema.
    Front Med (Lausanne) 2017 4;4:212. Epub 2017 Dec 4.
    Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
    Hereditary angioedema (HAE) is a group of rare, potentially life-threatening, and frequently debilitating diseases characterized by recurrent, and often with an unpredictable onset, of swelling attacks. HAE is heterogeneous, with considerable differences between its subtypes, patients, and even within the same patient over time. During the past few years, several new on demand and prophylactic therapies have become available for HAE, allowing for individualized treatment. Read More

    Omalizumab for refractory chronic spontaneous urticaria during concurrent immunomodulatory therapy for multiple sclerosis.
    Eur Ann Allergy Clin Immunol 2017 Nov;49(6):286-287
    Allergy Department, "Sotiria" General Hospital, Athens, Greece.
    Summary: Data derived from previous clinical trials and real-life studies have shown that omalizumab may represent an effective third-line treatment option for patients with chronic spontaneous urticaria (CSU) refractory to standard antihistamine treatment. Nevertheless, the safety and efficacy of omalizumab treatment for CSU, when administered concurrently with other immunomodulatory agents remains largely unknown. We herein present the case of a female patient with relapsing-remitting multiple sclerosis (RRMS), under treatment with interferon beta-1a, azathioprine and gabapentin, who was successfully treated with omalizumab for refractory CSU. Read More

    [Hereditary angioedema by C1 inhibitor-deficit: Diagnostic and therapeutic challenges. Case report].
    Rev Alerg Mex 2017 Oct-Dec;64(4):493-498
    Centro de Neumología y Alergias, San Pedro Sula, Cortés, Honduras.
    Background: Hereditary angioedema is a disease which manifests itself with episodes of spontaneous edema on skin, mucosal and airway. Treatment includes acute and prophylactic approach to minimize the attacks and severity. In many parts of the world, androgen derivatives, antifibrinolytic and fresh frozen plasma are the therapies available for prophylaxis. Read More

    Use of a Penicillin Allergy Screening Algorithm and Penicillin Skin Testing for Transitioning Hospitalized Patients to First-Line Antibiotic Therapy.
    J Allergy Clin Immunol Pract 2017 Dec 11. Epub 2017 Dec 11.
    Department of Medicine, Division of Allergy/Immunology/Rheumatology, Rochester Regional Health, Rochester, NY. Electronic address:
    Background: Penicillin allergy is the most commonly reported antibiotic allergy. Avoidance of β-lactam antibiotics in hospitalized patients leads to the use of second-line therapies.

    Objective: The utility of a penicillin allergy history algorithm (PAHA) and subsequent penicillin skin testing (PST) in transitioning hospitalized patients from second- to first-line antibiotic therapy is described. Read More

    Recognizing a Rare Phenomenon of Angiotensin-Converting Enzyme Inhibitors: Visceral Angioedema Presenting with Chronic Diarrhea-A Case Report.
    Perm J 2017 ;22
    Internist at East Tennessee State University in Johnson City.
    Introduction: Peripheral angioedema of the face and upper airways is a well-known phenomenon of angiotensin-converting enzyme inhibitors occurring in only 0.1% to 0.7% of patients. Read More

    Asthma, Family History of Drug Allergy, and Age Predict Amoxicillin Allergy in Children.
    J Allergy Clin Immunol Pract 2017 Dec 6. Epub 2017 Dec 6.
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Pediatrics, Edit Wolfson Medical Center, Holon, Israel.
    Background: Suspected adverse reactions to amoxicillin are common, but there are no known factors that can predict amoxicillin allergy in children. In addition, methods used for the diagnosis of amoxicillin allergy are not standardized and their role in diagnosis is not clear.

    Objective: To identify predictive factors and to assess the role of skin test in the diagnosis of amoxicillin allergy in children. Read More

    Investigational drugs in phase I and phase II clinical trials for hereditary angioedema.
    Expert Opin Investig Drugs 2018 Jan 15;27(1):87-103. Epub 2017 Dec 15.
    a Hungarian Angioedema Center, 3rd Department of Internal Medicine , Semmelweis University , Budapest , Hungary.
    Introduction: Hereditary angioedema (HAE) with C1-inhibitor deficiency (C1-INH-HAE) is a rare bradykinin-mediated disease characterized by recurrent subcutaneous and/or submucosal angioedematous attacks (HAE attacks), which occur unpredictably. The recurrent HAE attacks do not respond to conventional treatments, and may evolve into a life-threatening condition; therefore, special therapy is required. Areas covered: The agents used so far for the acute management of HAE attacks act by blocking the release of bradykinin, or its binding to its receptor. Read More

    Immunological Rare Diseases.
    Adv Exp Med Biol 2017 ;1031:497-509
    Department of Clinical and Biological Sciences, Turin University, Turin, Italy.
    The immune system is delegated to defend the body from attacks from outside or inside. Many diseases can affect immune system reducing its ability to defend self or inducing an abnormal response against external or internal antigens. Rare diseases affecting immune system present some issue in common with other rare diseases and some peculiarities due to the huge variability in the disease's expression. Read More

    Pharmacological Management of Hereditary Angioedema with C1-Inhibitor Deficiency in Pediatric Patients.
    Paediatr Drugs 2017 Dec 7. Epub 2017 Dec 7.
    3rd Department of Internal Medicine, Hungarian Angioedema Center, Semmelweis University, Kútvölgyi street 4, Budapest, 1125, Hungary.
    Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is a form of bradykinin-mediated angioedema. It is a rare disorder with an onset during childhood in most instances. Therefore, familiarity with the options for the management of pediatric cases is indispensable. Read More

    The Search for Biomarkers in Hereditary Angioedema.
    Front Med (Lausanne) 2017 22;4:206. Epub 2017 Nov 22.
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
    The unpredictable nature of attacks of tissue swelling in hereditary angioedema requires the identification of reliable biomarkers to monitor disease activity as well as response to therapy. At present, one can assess a C4 level (by ELISA) to assist in diagnosis but neither C4 nor C1 inhibitor levels reflect clinical course or prognosis. We will here review a collection of plasma proteins involved in blood coagulation, fibrinolysis, and innate immunity (Figure 1). Read More

    Long-term "real-life" safety of omalizumab in patients with severe uncontrolled asthma: A nine-year study.
    Respir Med 2017 Sep 19;130:55-60. Epub 2017 Jul 19.
    School and Chair of Allergology and Clinical Immunology, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Italy.
    Background: Randomized Controlled Trials showed that omalizumab exhibited a good safety and tolerability profile in patients with moderate-to-severe asthma. However, safety data of long-term treatment with omalizumab are scarce. Our aim was to assess the safety of omalizumab in patients under long-term treatment in a real-life setting. Read More

    The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme.
    J Med Chem 2018 Jan 21;61(1):344-359. Epub 2017 Dec 21.
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Observatory 7925, South Africa.
    Angiotensin-I converting enzyme (ACE) is a zinc metalloprotease consisting of two catalytic domains (N- and C-). Most clinical ACE inhibitor(s) (ACEi) have been shown to inhibit both domains nonselectively, resulting in adverse effects such as cough and angioedema. Selectively inhibiting the individual domains is likely to reduce these effects and potentially treat fibrosis in addition to hypertension. Read More

    Anaphylactic shock following castor bean contact: a case report.
    Allergy Asthma Clin Immunol 2017 24;13:50. Epub 2017 Nov 24.
    Division of Immunology and Allergology, Department of Medical Specialties, University Hospital and Medical Faculty, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva, Switzerland.
    Background: The castor bean plant, Ricinus communis, is known to have allergenic and toxic properties. Castor bean allergy has been described mainly as an occupational inhalation allergy in laboratory workers, in persons working in oil processing mills or in agricultural industry. So far, only one case of anaphylactic reaction due to castor bean sensitization confirmed by specific IgE has been described in literature. Read More

    A Multicenter Study of IgE Sensitization to Anisakis simplex and Diet Recommendation
    Endocr Metab Immune Disord Drug Targets 2017 11 29. Epub 2017 Nov 29.
    Department of Basic Medical Sciences, Neuroscience and Sensory Organ, University of Bari, School of Medicine, Bari. Italy.
    Background: Allergy to Anisakis simplex (s.) is spreading due to the increased consumption of raw, smoked or marinated fish. In humans, Anisakis s. Read More

    A Database Cohort Study to Assess the Risk of Angioedema Among Patients with Heart Failure Initiating Angiotensin-Converting Enzyme Inhibitors in the USA.
    Am J Cardiovasc Drugs 2017 Nov 24. Epub 2017 Nov 24.
    Novartis Pharma AG, Postfach, 4002, Basel, Switzerland.
    Introduction: Real-world evidence on the risk of angioedema associated with angiotensin-converting enzyme inhibitors (ACEIs) in patients with heart failure (HF) is scarce.

    Objective: This non-interventional study aimed to estimate the incidence of and risk factors for angioedema in patients with HF initiating an ACEI in real-world practice.

    Methods: This was a retrospective cohort study using claims data from the PharMetrics Plus database, supplemented with consumer health data, from 1 January 2007 to 31 March 2015. Read More

    HLAs: Key regulators of T-cell-mediated drug hypersensitivity.
    HLA 2018 Jan;91(1):3-16
    Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Australia.
    Adverse drug reactions (ADR) can be broadly categorised as either on-target or off-target. On-target ADRs arise as a direct consequence of the pharmacological properties of the drug and are therefore predictable and dose-dependent. On-target ADRs comprise the majority (>80%) of ADRs, relate to the drug's interaction with its known pharmacological target and are a result of a complex interplay of genetic and ecologic factors. Read More

    Outcomes of long term treatments of type I hereditary angioedema in a Turkish family.
    An Bras Dermatol 2017 Sep-Oct;92(5):655-660
    Dermatovenereology Clinic, Ataturk Training and Research Hospital - Ankara, Turkey.
    Background: Hereditary angioedema is a rare autosomal dominantly inherited immunodeficiency disorder characterized by potentially life-threatening angioedema attacks.

    Objective: We aimed to investigate the clinical and genetic features of a family with angioedema attacks.

    Methods: The medical history, clinical features and C1-INH gene mutation of a Turkish family were investigated and outcomes of long-term treatments were described. Read More

    Use of Health Care Databases to Support Supplemental Indications of Approved Medications.
    JAMA Intern Med 2018 Jan;178(1):55-63
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
    Importance: Manufacturers of US Food and Drug Administration-approved prescription drugs often apply for additional indications based on randomized clinical trials. Real-world database analyses on a medication's use and outcomes in routine settings of care might help to inform decision making regarding such supplemental indications.

    Objective: To examine whether longitudinal data from a health care database can support the results of a randomized clinical trial that led to a supplemental indication for telmisartan. Read More

    [Observation of systemic adverse reactions by specific immunotherapy and analysis of risk factors in allergic rhinitis].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Nov;52(11):801-805
    Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
    Objective: To investigate the systemic adverse effects of specific subcutaneous immunotherapy (SCIT) in patients with allergic rhinitis (AR) and explore the possible risk factors. Methods: A retrospective study was conducted on AR patients who underwent SCIT from January 2014 to January 2017 in Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University. For patients with adverse reactions, the detailed medical history during treatment was reviewed. Read More

    Safety of the neprilysin/renin-angiotensin system inhibitor LCZ696.
    Oncotarget 2017 Oct 31;8(47):83323-83333. Epub 2017 May 31.
    Department of Cardiology, Qilu Hospital of Shandong University, Ji'nan, 250012, PR China.
    Objectives: The combined neprilysin/rennin-angiotensin system inhibitor sacubitril/valsartan (LCZ696) has shown its superiority over ACEI/ARB therapy. In view of the existing concern of its adverse effects, we aimed to provide evidence of the safety of the new drug.

    Results: A total of 6 randomized trials with 11,821 subjects were included in this analysis. Read More

    Genetic Determinants of C1 Inhibitor Deficiency Angioedema Age of Onset.
    Int Arch Allergy Immunol 2017 9;174(3-4):200-204. Epub 2017 Nov 9.
    Department of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
    Background: In view of the large heterogeneity in the clinical presentation of hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE), great efforts are being made towards detecting measurable biological determinants of disease severity that can help to improve the management of the disease. Considering the central role that plasma kallikrein plays in bradykinin production, we investigated the contribution of the functional polymorphism KLKB1-428G/A to the disease phenotype.

    Methods: We studied 249 C1-INH-HAE patients from 114 European families, and we explored possible associations of C1-INH-HAE clinical features with carriage of KLKB1-428G/A, combined or not with that of the functional F12-46C/T polymorphism. Read More

    C-reactive protein is linked to disease activity, impact, and response to treatment in patients with chronic spontaneous urticaria.
    Allergy 2017 Nov 12. Epub 2017 Nov 12.
    Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
    Background: Elevated levels of C-reactive protein (CRP), a sensitive marker of inflammation, have been consistently reported in chronic spontaneous urticaria (CSU). Here, we retrospectively analyzed data from 1253 CSU patients from 2 centers to answer the following questions: (i) What is the prevalence of elevated levels of CRP in CSU? (ii) Why do CSU patients show elevated levels of CRP? (iii) Are elevated CRP levels relevant?

    Methods: Serum levels of CRP were measured by the nephelometric method. We collected information regarding various laboratory tests including ESR, CBC with differential, D-dimer, fibrinogen, C3, C4, IL-6, etc. Read More

    Hereditary Angioedema with Normal C1 Inhibitor and F12 Mutations in 42 Brazilian Families.
    J Allergy Clin Immunol Pract 2017 Nov 8. Epub 2017 Nov 8.
    Division of Clinical Immunology, Faculdade de Medicina ABC, Santo André, SP, Brazil. Electronic address:
    Background: Hereditary angioedema (HAE) with normal C1 inhibitor (C1-INH) is a rare condition with clinical features similar to those of HAE with C1-INH deficiency. Mutations in the F12 gene have been identified in subsets of patients with HAE with normal C1-INH, mostly within families of European descent.

    Objectives: Our aim was to describe clinical characteristics observed in Brazilians from 42 families with HAE and F12 gene mutations (FXII-HAE), and to compare these findings with those from other populations. Read More

    Management of pediatric 'cannot intubate, cannot oxygenate'.
    Acute Med Surg 2017 Oct 18;4(4):462-466. Epub 2017 Aug 18.
    Department of Emergency and Critical Care MedicineJapanese Red Cross Society Kyoto Daini HospitalKyotoJapan.
    Case: "Cannot intubate, cannot oxygenate" (CICO) is a rare, life-threatening situation. We describe a pediatric case of CICO and highlight some educational points.A 3-year-old boy who collapsed in the bathtub came to our emergency department. Read More

    Recurrent ascites: a need to evaluate for hereditary angio-oedema.
    Lancet 2017 Nov;390(10107):2119-2120
    Allergy-Immunology Department, Mureș County Hospital, Târgu Mureș, Romania; University of Medicine and Pharmacy, Târgu Mureș, Romania; Romanian Network for Hereditary Angioedema, Romania.

    Hypocomplementemic Urticarial Vasculitis Syndrome with Membranous Nephropathy: Case Report.
    J Korean Med Sci 2017 Dec;32(12):2064-2068
    Division of Rheumatology, Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
    Urticarial vasculitis is a rare disorder that principally manifests with recurrent urticarial, sometimes hemorrhagic, skin lesions and/or angioedema. Its clinical presentation is not always limited to cutaneous lesions and it can potentially affect other organs, such as the joints, lungs, kidneys, and eyes. Systemic involvement can either be present at the onset of disease or develop over time. Read More

    1 OF 149