2,005 results match your criteria Angiodysplasia of the Colon


Severe aortic stenosis, critical coronary artery disease, and transfusion-dependent angiodysplasia - A management conundrum.

J Cardiol Cases 2016 Mar 11;13(3):87-89. Epub 2015 Dec 11.

Department of Cardiology, Leeds General Infirmary, Leeds, United Kingdom.

The combination of severe aortic stenosis, bleeding due to Heyde's syndrome and critical coronary artery disease presents a management challenge. We report the case of an 86-year-old who underwent percutaneous coronary intervention to the right coronary artery, simultaneous balloon aortic valvuloplasty to treat aortic stenosis and address bleeding from Heyde's syndrome, and subsequent staged transcatheter aortic valve implantation. < The combination of severe aortic stenosis (AS), bleeding due to Heyde's syndrome and critical coronary artery disease presents a management challenge. Read More

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Reversal of angiodysplasia-derived anemia after transcatheter aortic valve implantation.

J Cardiol Cases 2012 Apr 16;5(2):e128-e131. Epub 2012 Mar 16.

Cardiovascular Department, University Hospital of Trieste, Via Valdoni 7, 34149 Trieste, Italy.

Aortic valve stenosis associated with angiodysplasia (Heyde's syndrome) and consequent anemia had previously been reported to benefit from surgical aortic valve replacement. In this clinical case an 89-year-old patient with chronic angiodysplasia-derived anemia, characterized by acute phases of active gastrointestinal bleeding experienced a normalization of hemoglobin values after a trans-catheter aortic valve implantation (TAVI) of a self-expandable aortic valve prosthesis (CoreValve, Medtronic Inc., Minneapolis, MN, USA). Read More

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April 2012
1 Read

Microcystin-LR induces angiodysplasia and vascular dysfunction through promoting cell apoptosis by the mitochondrial signaling pathway.

Chemosphere 2018 Nov 17;218:438-448. Epub 2018 Nov 17.

Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), State and Local Joint Engineering Laboratory for Vascular Implants (Chongqing), Bioengineering College of Chongqing University, Chongqing 400030, China. Electronic address:

The harmful algal blooms are becoming increasingly problematic in the regions that drinking water production depends on surface waters. With a global occurrence, microcystins are toxic peptides produced by multiple cyanobacterial genera in the harmful algal blooms. In this study, we examined the effects of microcystin-LR (MC-LR), a representative toxin of the microcystin family, on vascular development in zebrafish and the apoptosis of human umbilical vein endothelial cells (HUVECs). Read More

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November 2018

Is a bleeding scan prior to single-balloon enteroscopy necessary in patients with obscure gastrointestinal bleeding?

J Formos Med Assoc 2018 Nov 23. Epub 2018 Nov 23.

Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan; Taiwan Association for the Study of Small Intestinal Diseases, Taoyuan, Taiwan. Electronic address:

Background/purpose: To evaluate the efficacy and accuracy of bleeder localization in a pre-enteroscopic bleeding scan in patients with obscure gastrointestinal bleeding (OGIB).

Methods: From January 2009 to December 2014, 98 patients with OGIB undergoing single-balloon enteroscopy (SBE) were enrolled. These patients were classified based on their history of a previous bleeding scan; 56 patients had undergone a previous bleeding scan, whereas 42 had not. Read More

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November 2018
4 Reads

Digoxin Is Associated With a Decreased Incidence of Angiodysplasia-Related Gastrointestinal Bleeding in Patients With Continuous-Flow Left Ventricular Assist Devices.

Circ Heart Fail 2018 Aug;11(8):e004899

Division of Cardiology, Department of Medicine (S.V., P.P.V., S.R.P., S.G.S., O.S., D.B.S., T.C., J.J.S., U.P.J.).

Background: Gastrointestinal bleeding (GIB) is one of the principal adverse events affecting patients with continuous-flow left ventricular assist devices (CF-LVADs). Despite the early recognition that GIB is commonly because of gastrointestinal angiodysplasia (GIAD), the exact pathophysiology of this process remains elusive. It has been postulated that the abnormal hemodynamic profile in CF-LVAD patients may activate the angiogenesis signaling cascade via the HIF (hypoxia-inducible factor)-1α/angiopoietin-2 pathway leading to formation of GIADs. Read More

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August 2018
9 Reads

Clinical and In Vitro Evidence That Left Ventricular Assist Device-Induced von Willebrand Factor Degradation Alters Angiogenesis.

Circ Heart Fail 2018 Sep;11(9):e004638

Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia (C.R.B., S.H.-S., C.B., P.A., M.A.A.).

Background Gastrointestinal bleeding from angiodysplasia is a major problem in continuous-flow left ventricular assist device (LVAD) patients. LVAD shear stress causes pathologic degradation of VWF (von Willebrand factor). A mechanistic relationship between VWF degradation and angiodysplasia has not been explored. Read More

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September 2018
6 Reads

Clinical characteristics and risk factors of active bleeding in colonic angiodysplasia among the Taiwanese.

J Formos Med Assoc 2018 Oct 19. Epub 2018 Oct 19.

Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Taiwan Association for the Study of Small Intestinal Diseases, Taoyuan, Taiwan. Electronic address:

Background: Colonic angiodysplasia (AGD) is a common cause of gastrointestinal bleeding. However, information on the characteristics and prevalence of colonic AGD is limited. We determined the clinical features of and risk factors for active bleeding in colonic AGD in a Taiwanese population. Read More

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October 2018
9 Reads

[A hemostatic disorder caused by high shear stress: acquired von Willebrand syndrome].

Rinsho Ketsueki 2018;59(10):2233-2237

Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer Tohoku University.

The von Willebrand factors (VWFs) play critical role in hemostasis and thrombosis formation. VWFs are produced in and secreted as large multimers from endothelial cells, and shear stress-dependently cleaved into 2-80 multimers by their specific protease, ADATS13. Because high molecular weight VWFs play important roles in platelet aggregation, the loss of high molecular weight VWFs caused by pathological high-shear stress induces a hemostatic disorder known as acquired von Willebrand syndrome (AVWS) type IIA. Read More

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January 2018
5 Reads

Continuous-Flow Left Ventricular Assist Device-Related Gastrointestinal Bleeding.

Cardiol Clin 2018 Nov;36(4):519-529

Advanced Heart Failure and Transplant, Pauley Heart Center, Virginia Commonwealth University, 1200 East Broad Street, PO Box: 980204, Richmond, VA 23298-0036, USA. Electronic address:

Continuous-flow (CF) left ventricular assist devices (LVADs) are a safe and durable therapeutic option for patients with advanced heart failure as a bridge to transplant or as destination therapy. Despite the remarkable technological advances in device design and increasing familiarity with the physiologic effects of CF, major complications such as gastrointestinal bleeding (GIB) continue to cause significant morbidity. The causes underlying CF-LVAD-related GIB are multifactorial. Read More

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November 2018
1 Read

The etiology of potential small-bowel bleeding depending on patient's age and gender.

United European Gastroenterol J 2018 Oct 30;6(8):1169-1178. Epub 2018 Sep 30.

Department of Internal Medicine, Institute of Digestive Diseases and Nutrition, Korea University College of Medicine, Seoul, Korea.

Background: Whether the etiology of potential small-bowel bleeding depends on the age and gender of the patient is not yet fully understood.

Methods: A total of 1953 patients who underwent video capsule endoscopy (VCE) to evaluate potential small-bowel bleeding and were registered in the Capsule Endoscopy Nationwide Database Registry from 2003 to 2014 were eligible for this study. VCE findings and the etiology of small-bowel bleeding were analyzed by age and gender. Read More

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October 2018
3 Reads

Gastrointestinal lesions in chronic kidney disease patients with anaemia.

Nefrologia 2018 Aug 25. Epub 2018 Aug 25.

Departamento de Citología e Histología Normal y Patológica, Facultad de Medicina, Universidad de Sevilla, Sevilla, España.

Introduction: Despite the frequency with which anaemia is present in patients with chronic kidney disease (CKD), its relationship with gastrointestinal lesions has not been studied.

Method: A cross-sectional, analytical, observational study involving one year of recruitment was carried out to determine the prevalence of endoscopic gastrointestinal lesions and associated risk factors in asymptomatic patients with chronic kidney disease stages 1-5 and anaemia who had a positive qualitative immunochemical faecal occult blood test.

Results: A total of 9,658 patients with CKD were analysed, of which 286 (2. Read More

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August 2018
10 Reads

A Case of Heyde Syndrome with Resolution of Gastrointestinal Bleeding Two Weeks After Aortic Valve Replacement.

Am J Case Rep 2018 Aug 7;19:924-926. Epub 2018 Aug 7.

Department of Gastroenterology, North Bay Medical Center, Fairfield, CA, USA.

BACKGROUND Heyde syndrome is the association between gastrointestinal (GI) bleeding from arteriovenous malformation (AVM) and aortic stenosis. The aim of this study was to review Heyde syndrome and to discuss the management of this condition. CASE REPORT A 56-year-old female with a history of severe aortic stenosis and recurrent GI bleeding secondary to small bowel AVM, presented for hospital admission with melena and maroon blood in her stool. Read More

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August 2018
1 Read

An overview of angiodysplasia: management and patient prospects.

Expert Rev Gastroenterol Hepatol 2018 Sep 3;12(9):863-872. Epub 2018 Aug 3.

a Department of Gastroenterology and Clinical Medicine , Trinity Centre for Health Sciences' Tallaght Hospital , Dublin , Ireland.

Introduction: Gastrointestinal angiodysplasias (GIADs) have a wide variety of presentations, which can be significant and debilitating in a subset of patients. Endoscopic ablation is currently the most effective treatment for GIADs, however re-bleeding rates are high. Several medical have been used for GIADs and reported in the literature, however these medications have significant side effect profiles and randomized controlled trials are lacking. Read More

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September 2018
2 Reads

Aortic stenosis and anemia with an update on approaches to managing angiodysplasia in 2018.

Cardiol J 2018 Jul 16. Epub 2018 Jul 16.

Kings College London, London, UK; Department of Cardiology, Medical University of Gdansk, Poland.

Angiodyplasia and aortic stenosis are both conditions that are highly prevalent in elderly people and can often co-exist. Recent studies suggest that this association is related to subtle alterations in plasma coagulation factors. The Von Willebrand factor is the strongest link between aortic stenosis and bleeding associated with gastrointestinal angiodysplasia. Read More

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July 2018
5 Reads

Initial experience of video capsule endoscopy at a tertiary center in Saudi Arabia.

Saudi J Gastroenterol 2018 Nov-Dec;24(6):355-359

Gastroenterology and Endoscopy Unit, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Background/aim: No prior experience with video capsule endoscopy (VCE) has been published from Saudi Arabia. In this study, we aim to report the first Saudi experience with VCE.

Patients And Methods: A prospective study was conducted between March 2013 and September 2017 at King Abdulaziz Medical City, Riyadh, Saudi Arabia. Read More

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July 2018
7 Reads

Fleeting Angiodysplasia.

GE Port J Gastroenterol 2018 Jun 7;25(4):203-204. Epub 2017 Oct 7.

Gastroenterology Department, Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.

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June 2018
2 Reads

Gastric Antral Vascular Ectasia Pathogenesis and the Link to the Metabolic Syndrome.

Curr Gastroenterol Rep 2018 Jul 2;20(8):36. Epub 2018 Jul 2.

Division of Gastroenterology and Hepatology, University of Virginia, JPA and Lee St., PO Box 800708, Charlottesville, VA, 22908-0708, USA.

Purpose Of Review: Gastric antral vascular ectasia (GAVE) is a well-described source of chronic blood loss. We aim to review the previously hypothesized etiologies of GAVE and focus on recent proposed mechanisms, including metabolic syndrome. We will support these theories with newly discovered clinical associations and possible therapeutic implications. Read More

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July 2018
1 Read

Klippel-Trenaunay and Parkes-Weber syndromes: two case reports.

J Vasc Bras 2017 Oct-Dec;16(4):320-324

Universidade de São Paulo - USP, School of Medicine, Unit of Interventional Radiology, São Paulo, SP, Brazil.

Parkes-Weber syndrome is a congenital vascular disease that comprises capillary, venous, lymphatic, and arteriovenous malformations. Although Parkes-Weber syndrome is a clinically distinct entity with serious complications, it is still frequently misdiagnosed as Klippel-Trenaunay syndrome, which consists of a triad of malformations involving the capillary, venous, and lymphatic vessels, without arteriovenous fistulas. Both syndromes are generally diagnosed with Doppler ultrasound and confirmed by magnetic resonance angiography. Read More

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June 2018
1 Read

Successful Treatment of Recurrent Gastrointestinal Bleeding Due to Small Intestine Angiodysplasia and Multiple Myeloma with Thalidomide: Two Birds with One Stone

Turk J Haematol 2018 Nov 18;35(4):305-306. Epub 2018 Jun 18.

University Hospital Center Zagreb, Department of Internal Medicine, Division of Hematology, Zagreb, Croatia

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November 2018

Ileal tubular adenoma as a cause of lower gastrointestinal bleeding in infants.

Rev Esp Enferm Dig 2018 Aug;110(8):532-533

Gastroenterología, Instituto de Gastroenterologia Boliviano Japonez, Bolivia.

Lower gastrointestinal bleeding is a common pathology with diverse causes depending on the patients´ age. The most common causes in adults are polyps, neoplasias, diverticular disease and angiodysplasia. In neonates, necrotizing enterocolitis and volvulus, and anal fissures and bowel intussusception in infants. Read More

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August 2018
1 Read

Polypoid angiodysplasia mimicking diverticular disease.

Gastroenterol Hepatol 2018 Nov 5;41(9):574-575. Epub 2018 Jun 5.

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Complejo Hospitalario Guillermo Kaelin de la Fuente, Lima, Peru.

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November 2018

Diagnostic yield and predictive factors of findings in small-bowel capsule endoscopy in the setting of iron-deficiency anemia.

Endosc Int Open 2018 Jun 25;6(6):E688-E693. Epub 2018 May 25.

Clinica de Gastroenterología "Prof. Henry Cohen", Hospital de Clínicas, UDELAR, Montevideo, Uruguay.

Introduction:  Despite the widespread use of small-bowel capsule endoscopy (CE), there is still limited data on its utility and effectiveness for the diagnosis and management of patients with iron-deficiency anemia (IDA).

Aim:  To assess the diagnostic yield of CE and the factors predicting positive findings in patients with IDA.

Methods:  Patients with unexplained IDA and negative upper and lower endoscopy were included. Read More

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von Willebrand factor regulation of blood vessel formation.

Blood 2018 Jul 4;132(2):132-140. Epub 2018 Jun 4.

Center for Bleeding Disorders and Coagulation, Department of Oncology, Careggi University Hospital, Florence, Italy.

Several important physiological processes, from permeability to inflammation to hemostasis, take place at the vessel wall and are regulated by endothelial cells (ECs). Thus, proteins that have been identified as regulators of one process are increasingly found to be involved in other vascular functions. Such is the case for von Willebrand factor (VWF), a large glycoprotein best known for its critical role in hemostasis. Read More

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Multicenter prospective evaluation of the express view reading mode for small-bowel capsule endoscopy studies.

Endosc Int Open 2018 May 8;6(5):E616-E621. Epub 2018 May 8.

Gastroenterology Department, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, Paris, France.

Background:  Reducing the reading time of capsule endoscopy films is of high priority for gastroenterologists. We report a prospective multicenter evaluation of an "express view" reading mode (Intromedic capsule system).

Methods:  Eighty-three patients with obscure gastrointestinal bleeding were prospectively included in 10 centers. Read More

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May 2018
1 Read

Correction of a dominant-negative von Willebrand factor multimerization defect by small interfering RNA-mediated allele-specific inhibition of mutant von Willebrand factor.

J Thromb Haemost 2018 Jul 1;16(7):1357-1368. Epub 2018 Jun 1.

Department of Internal Medicine (Thrombosis and Hemostasis), Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.

Essentials Substitution therapy for von Willebrand (VW) disease leaves mutant VW factor (VWF) unhindered. Presence of mutant VWF may negatively affect phenotypes despite treatment. Inhibition of VWF by allele-specific siRNAs targeting single-nucleotide polymorphisms is effective. Read More

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Fifth Åland Island conference on von Willebrand disease.

Haemophilia 2018 May;24 Suppl 4:5-19

Department of Disorders of Hemostasis and Internal Medicine, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.

The fifth Åland Island meeting on von Willebrand disease (VWD) was held on the Åland Islands, Finland, from 22 to 24 September 2016-90 years after the first case of VWD was diagnosed in a patient from the Åland Islands in 1926. This meeting brought together experts in the field of VWD to share knowledge and expertise on current trends and challenges in VWD. Topics included the storage and release of von Willebrand factor (VWF), epidemiology and diagnostics in VWD, treatment of VWD, angiogenesis and VWF inhibitors. Read More

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Colonic Mucosal Ulceration and Gastrointestinal Bleeding Associated with Sevelamer Crystal Deposition in a Patient with End Stage Renal Disease.

Case Rep Nephrol 2018 28;2018:4708068. Epub 2018 Feb 28.

Hematology and Oncology, Cancer Treatment Centers of America, Tulsa, OK, USA.

End stage renal disease (ESRD) population account for 1.9 per patient year of hospital admissions annually. ESRD population are at increased risk of bleeding secondary to use of anticoagulation during hemodialysis and uremia induced platelet dysfunction. Read More

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February 2018
2 Reads

[Rectal bleeding in a 60-year-old woman under anticoagulation and platelet aggregation inhibition].

Internist (Berl) 2018 09;59(9):967-971

Notfall- und Akutmedizin mit Chest Pain Units, Campus Charité Mitte und Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.

Case Report: We report on a woman with lower gastrointestinal bleeding under effective oral anticoagulation with both phenprocoumon and apixaban (with intention to switch to the latter) as well as the antiplatelet agent acetylsalicylic acid for aortic bifurcation kissing stents after stent thrombosis. Our patient presented with weakness and rectal bleeding. Upon examination, she looked anemic and had sinus tachycardia (104 beats per minute). Read More

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September 2018
17 Reads

Association between patient characteristics and magnetically controlled capsule endoscopy findings.

Saudi J Gastroenterol 2018 May-Jun;24(3):189-195

Department of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.

Background/aim: Magnetically-controlled capsule endoscopy (MCE) is a potential option for the evaluation of gastric diseases in cases that are unsuited for conventional endoscopy, avoiding discomfort, sedation, and related complications. This retrospective study investigated associations between MCE findings and patient gender, age, and inpatient/outpatient status.

Patients And Methods: The data of 580 consecutive patients who underwent MCE from 2015 to 2016 were analyzed. Read More

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November 2018
7 Reads

Small bowel capsule endoscopy revealing neuromuscular and vascular hamartoma of the jejunum: A case report.

Medicine (Baltimore) 2018 Apr;97(15):e0196

Department of Gastroenterology, National Institute of Gastroenterology "S. de Bellis", Research Hospital, Castellana Grotte, Bari, Italy.

Rationale: Digestive hemorrhage is a life-threatening and represents for both clinicians and patient a challenger problematic condition with the urgencies to discover the origin for correct the cause and safe the life of patient.

Patient Concerns: We report the case of a 58 -year-old man with extremely rare hamartomatous neurovascular lesion. Following recurrent episode of intestinal hemorrhage the patient underwent small bowel capsule endoscopy. Read More

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April 2018
2 Reads

Pharmacological treatment of gastrointestinal bleeding due to angiodysplasias: A position paper of the Italian Society of Gastroenterology (SIGE).

Dig Liver Dis 2018 Jun 15;50(6):542-548. Epub 2018 Feb 15.

Department of Clinical Medicine and Surgery, Federico II University, Napoli, Italy.

Angioectasias (AD) belong to benign vascular malformations of the gastrointestinal tract and are responsible for about 4-7% of upper non variceal bleeding, 30-40% of small bowel occult bleeding and 3-40% of colonic bleeding episodes. Gastrointestinal haemorrhage secondary to AD represents an important diagnostic and therapeutic problem that negatively impacts on the quality of life of patients and heath care costs. Endoscopic interventions are the mainstay in both diagnosis and treatment of vascular malformations. Read More

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June 2018
4 Reads

Emerging role of thalidomide in the treatment of gastrointestinal bleeding.

Frontline Gastroenterol 2018 Apr 2;9(2):98-104. Epub 2017 Nov 2.

Department of Gastroenterology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

Thalidomide was initially synthesised in 1954 and marketed as a sedative and antiemetic for morning sickness. It was withdrawn in 1961 due to the realisation that it was teratogenic with over 10 000 children born with congenital abnormalities. Since then it has been used for treatment of dermatological and oncological conditions, including myeloma. Read More

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Locations and Mucosal Lesions Responsible for Major Gastrointestinal Bleeding in Patients on Warfarin or Dabigatran.

Dig Dis Sci 2018 07 27;63(7):1878-1889. Epub 2018 Mar 27.

Department of Gastroenterology and Hepatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background And Aim: Different oral anticoagulants may be associated with gastrointestinal bleeding (GIB) from different locations or mucosal lesions. We aimed to test this hypothesis.

Methods: Two blinded gastroenterologists independently analyzed source documents from the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial of dabigatran 150 mg BID (D150), dabigatran 110 mg BID (D110) versus warfarin in non-valvular atrial fibrillation (NVAF). Read More

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July 2018
6 Reads

Diagnostic value of OMOM capsule endoscopy for small bowel diseases in adults.

Exp Ther Med 2018 Apr 13;15(4):3467-3470. Epub 2018 Feb 13.

Department of Gastroenterology, Xinghua Hospital, Xinghua, Jiangsu 225700, P.R. China.

The present study aimed to determine the diagnostic yield of OMOM capsule endoscopy for small bowel diseases in adults. A total of 89 patients, including 45 cases of obscure abdominal pain, 22 of chronic diarrhea, 18 of obscure gastrointestinal bleeding and 4 of obscure anemia were enrolled in the present study. The transit time of the endoscopy capsule in the digestive tract was recorded and the testing results were analyzed. Read More

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Evaluation and management of lower gastrointestinal bleeding.

Dis Mon 2018 Jul 7;64(7):321-332. Epub 2018 Mar 7.

Division of Gastroenterology & Hepatology, University of Texas Medical Branch, 7400 Jones Drive, Apt 724, Galveston, TX 77551. Electronic address:

Lower gastrointestinal bleeding (LGIB) is a common cause of presentation to the emergency department and hospital admissions. The incidence of LGIB increases with age and the most common etiologies are diverticulosis, angiodysplasia, malignancy and anorectal diseases. Foremost modality for evaluation and treatment of LGIB is colonosopy. Read More

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July 2018
5 Reads
0.540 Impact Factor

Colonic angiodysplasia on CT colonography: case report and characteristic imaging findings.

Radiol Case Rep 2017 Dec 14;12(4):693-696. Epub 2017 Aug 14.

Department of Diagnostic and Interventional Radiology, Molecular Imaging and Radiotherapy, PTV Foundation, "Tor Vergata" University of Rome, Viale Oxford 81, 00133 Rome, Italy.

Gastrointestinal angiodysplasia represents the cause of 6% of lower gastrointestinal tract bleeding, particularly in the elderly. Because of the common presentation and age range of affected patients, often patients with occult or massive gastrointestinal bleedings are investigated with colonoscopy, in the suspect of colonic cancer. Other methods are capsule enteroscopy, angiography, double-contrast barium enema, computed tomography angiography, and radionuclide scanning. Read More

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December 2017
2 Reads

Clinical presentation and treatment paradigms of brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia.

J Clin Neurosci 2018 May 23;51:22-28. Epub 2018 Feb 23.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah School of Medicine, Salt Lake City, UT, United States; University of Utah Hereditary Hemorrhagic Telangiectasia Center of Excellence, Salt Lake City, UT, United States. Electronic address:

Hereditary hemorrhagic telangiectasia (HHT) is characterized by recurrent spontaneous epistaxis, mucocutaneous telangiectases, and multisystem arteriovenous malformations (AVMs). Brain AVMs typically present at birth and are identified in approximately 10-20% of patients with HHT. A retrospective review was undertaken of all HHT patients with known single or multiple brain AVMs treated at our institution. Read More

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May 2018
2 Reads

Efficacy and safety of pasireotide-LAR for the treatment of refractory bleeding due to gastrointestinal angiodysplasias: results of the ANGIOPAS multicenter phase II noncomparative prospective double-blinded randomized study.

Therap Adv Gastroenterol 2018 16;11:1756283X18756260. Epub 2018 Feb 16.

Gastroenterology Unit, Dupuytren Hospital, Limoges, France.

Background: Gastrointestinal angiodysplasias (GIADs) could be responsible for recurrent bleeding and severe anemia. Somatostatin analogs could reduce transfusion requirements in these patients but no randomized controlled study is available. The main objective of the ANGIOPAS phase II double-blinded randomized, noncomparative study was to assess the effectiveness of pasireotide-LAR in reducing transfusion requirements in patients with refractory GIADs bleeding. Read More

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February 2018
22 Reads

Pazopanib effective for bevacizumab-unresponsive epistaxis in hereditary hemorrhagic telangiectasia.

Laryngoscope 2018 Oct 16;128(10):2234-2236. Epub 2018 Feb 16.

Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, U.S.A.

Hereditary hemorrhagic telangiectasia (HHT) most commonly manifests with nasal mucosal telangiectasias, and vascular endothelial growth factor (VEGF) plays a significant role in this angiodysplasia. We describe a patient with HHT with epistaxis recalcitrant to several endonasal procedures and six cycles of intravenous bevacizumab, for which he was dependent on iron infusions and packed red blood cells transfusions. He then started pazopanib at 100 mg with dramatic improvements in epistaxis and normalization of hemoglobin and iron levels, without replenishment needs for 12 months. Read More

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October 2018
15 Reads

An Analysis of the Clinical, Laboratory, and Histological Features of Striped, Punctate, and Nodular Gastric Antral Vascular Ectasia.

Dig Dis Sci 2018 Apr 15;63(4):966-973. Epub 2018 Feb 15.

Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.

Background: Gastric antral vascular ectasia (GAVE) commonly presents as linear striped ("watermelon stomach") or punctate phenotypes, to which a newly discovered nodular form was recently added.

Aims: We performed a retrospective cohort study to detail and compare the clinical and histological characteristics of major GAVE phenotypes.

Methods: In 136 GAVE patients (tertiary care ambulatory and inpatient, median age 61. Read More

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Lenalidomide as a novel therapy for gastrointestinal angiodysplasia in von Willebrand disease.

Haemophilia 2018 Mar 15;24(2):278-282. Epub 2018 Feb 15.

Georgetown University, Washington, DC, USA.

Introduction: Lenalidomide is a thalidomide analog with anti-angiogenic properties. Previous case reports suggest its efficacy in preventing gastrointestinal bleeding (GIB) secondary to angiodysplasia (AD) in hereditary haemorrhagic telangiectasia and potentially in reversing AD. We present the first case series to explore lenalidomide as a treatment for AD-related GIB in patients with von Willebrand disease (VWD). Read More

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March 2018
1 Read
2.600 Impact Factor

Management of Acute Gastrointestinal Bleed.

Crit Care Nurs Clin North Am 2018 Mar 21;30(1):55-66. Epub 2017 Nov 21.

Austin Peay State University, School of Nursing, PO Box 4658, Clarksville, TN 37043, USA. Electronic address:

Acute gastrointestinal bleeding is a common problem found in critically ill patients that can range from self-limited bleeding to a hemorrhaging emergency. Patients can quickly develop shock and altered mental status when they develop hemodynamic instability. Therefore, it is essential that the frontline critical care nurse develop self-efficacy for management of these disorders. Read More

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March 2018
6 Reads

Clinical presentation and treatment paradigms in patients with hereditary hemorrhagic telangiectasia and spinal vascular malformations.

J Clin Neurosci 2018 Apr 3;50:51-57. Epub 2018 Feb 3.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah School of Medicine, Salt Lake City, UT, United States. Electronic address:

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder that causes angiodysplasia and results in mucocutaneous telangiectasias and arteriovenous malformations of organs. Although central nervous system vascular malformations can occur anywhere along the neuraxis, spinal vascular malformations are rare. We present our experience with the presentation and management of spinal vascular malformations in patients with HHT. Read More

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April 2018
7 Reads

Gastrointestinal Bleeding in Native and Prosthetic Valve Disease.

Curr Treat Options Cardiovasc Med 2018 Feb 3;20(1). Epub 2018 Feb 3.

Department of Cardiovascular Diseases, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Gastrointestinal bleeding with severe aortic stenosis was originally described in the 1950s by Heyde, although for years, the association was debated. Further discovery of mechanisms and the ubiquity and severity of acquired von Willebrand syndrome in the left ventricular assist device therapy have removed any doubts. At this time, gastrointestinal bleeding from intestinal angiodysplasia in patients with turbulence-related proteolysis of the highest molecular weight multimers of von Willebrand factor is now known to occur in patients with aortic stenosis, and also subaortic obstruction and associated mitral insufficiency in hypertrophic cardiomyopathy, isolated mitral and aortic insufficiency, endocarditis, and in patients with prosthetic valve dysfunction, either from stenosis or insufficiency. Read More

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February 2018
2 Reads

Emergency transcatheter arterial embolization for massive gastrointestinal arterial hemorrhage.

Medicine (Baltimore) 2017 Dec;96(52):e9437

Department of Interventional Radiology.

To evaluate the different arteriographic manifestations of acute arterial massive hemorrhage of the gastrointestinal (GI) tract and the efficacy of emergency transcatheter arterial embolization (ETAE).A total of 88 patients with acute massive GI bleeding who experienced failure of initial endoscopy and/or conservative treatment were referred to our interventional department for acute GI arteriography from January 2007 to June 2015. After locating the source of bleeding, appropriate embolic agents, such as spring coil, hydroxyl methyl acrylic acid gelatin microspheres, polyvinyl alcohol (PVA) particles, etc. Read More

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December 2017
7 Reads

Association of aortic valve disease with intestinal angioectasia: data from the Nationwide Inpatient Sample.

Eur J Gastroenterol Hepatol 2018 Apr;30(4):438-441

Department of Internal Medicine, Reading Health System, West Reading.

Objective: Since the description of a correlation between aortic stenosis and angioectasia, controversy has persisted about whether these diseases are truly associated or coincidental findings of older age. Our objective was to determine the association of aortic valve disease and bleeding intestinal angioectasia from a large database.

Patients And Methods: We used the 2011 Nationwide Inpatient Sample database to identify hospitalizations in the USA in patients with bleeding intestinal angioectasia. Read More

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April 2018
13 Reads
2.150 Impact Factor

Role of transesophageal echocardiography during left atrial appendage occlusion device closure in a patient with non-valvular atrial fibrillation and angiodysplasia of the colon.

Ann Card Anaesth 2018 Jan-Mar;21(1):88-91

Department of Cardiology, JSS Superspeciality Hospital and Medical College, JSS University, Mysore, Karnataka, India.

Atrial fibrillation is the most common arrhythmia associated with significant mortality and morbidity secondary to thrombo-embolism. To prevent this thrombo-embolism oral anticoagulation therapy is the recommended treatment. In patients with contraindications to oral anticoagulation therapy, percutaneous left atrial appendage occlusion device is indicated. Read More

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October 2018
4 Reads

Changing Epidemiology of Upper Gastrointestinal Hemorrhage in the Last Decade: A Nationwide Analysis.

Dig Dis Sci 2018 05 27;63(5):1286-1293. Epub 2017 Dec 27.

Division of Gastroenterology, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 803, MSC 623, Charleston, SC, 29425, USA.

Background: Upper gastrointestinal hemorrhage (UGIH) is common and carries substantial mortality requiring frequent hospitalizations.

Aim: To investigate trends in etiology and outcome of UGIH in hospitalized patients in the USA.

Methods: Retrospective, observational cohort study of the Nationwide Inpatient Sample from 2002 to 2012 was carried out. Read More

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May 2018
7 Reads

Refractory Anaemia Secondary to Small Bowel Angioectasias - Comparison between Endotherapy Alone versus Combination with Somatostatin Analogues.

J Gastrointestin Liver Dis 2017 Dec;26(4):369-374

Royal Hallamshire Hospital, Sheffield, UK.

Background And Aims: Patients with small bowel angioectasias (SBAs) can be difficult to manage as they are generally elderly with multiple co-morbidities. Angioectasias are multiple and tend to recur. Argon plasma coagulation (APC), despite being a commonly used method to treat these patients has an associated persistent rate of re-bleeding necessitating additional treatment to manage these patients. Read More

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December 2017
7 Reads

Multicenter Evaluation of Octreotide as Secondary Prophylaxis in Patients With Left Ventricular Assist Devices and Gastrointestinal Bleeding.

Circ Heart Fail 2017 Nov;10(11)

From The Pauley Heart Center (K.B.S., S.G., P.A.U., M.L.S.), Department of Pharmacotherapy and Outcomes Research (D.F.B.), and Division of Gastroenterology (G.B.S.), Virginia Commonwealth University, Richmond; Division of Cardiovascular Medicine, The Ohio State University, Columbus (S.E.); McGinnis Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA (M.K.K.); Division of Cardiology, University of Chicago, IL (N.U.); Division of Cardiology, Columbia University, New York, NY (P.C.C.); and Abbott, Pleasanton, CA (J.C., D.J.F.).

Background: Gastrointestinal (GI) bleeding is one of the most common complications after continuous-flow left ventricular assist device implantation. More than one third of patients with incident bleed go on to develop recurrent GI bleeding. Octreotide, a somatostatin analog, is proposed to reduce the risk of recurrent GI bleeding in this population. Read More

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November 2017
15 Reads