429 results match your criteria Angiodysplasia of the Colon


Colonic angiodysplasia: a culprit of obscure gastrointestinal bleeding in a patient with Heyde syndrome.

BMJ Case Rep 2022 Jan 13;15(1). Epub 2022 Jan 13.

General Surgery, Singapore General Hospital, Singapore.

A 77-year-old woman presented with obscure gastrointestinal bleeding requiring multiple hospitalisations and blood transfusions. The patient underwent repeated investigations over four hospital admissions across a span of two months. These included upper and lower gastrointestinal endoscopy, video capsule endoscopy as well as CT enterography, without definitive localisation or treatment of the source of bleeding. Read More

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January 2022

The differential diagnosis of ulcerative colitis versus angiodysplasia of the colon with ischemic colitis.

Rom J Morphol Embryol 2021 Apr-Jun;62(2):395-400

Department of Medical Sociology, University of Medicine and Pharmacy of Craiova, Romania;

Ulcerative colitis and Crohn's disease are the inflammatory bowel diseases with a continuously increasing of prevalence. Their exact causes are still not well known and, more than that, they are raising up serious issues of diagnosis. The same difficulties of diagnosis are encountered in the case of the colonic angiodysplasia or ischemic colitis (IC). Read More

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January 2022

Aortic Valve Replacement for Patients with Heyde Syndrome: A Literature Review.

Chin Med Sci J 2021 Dec;36(4):307-315

Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.

Objective To explore the characteristics and clinical outcomes of patients with Heyde syndrome (HS) who undergo aortic valve replacement (AVR). Methods Electronic databases including PubMed, Embase, Ovid, WANFANG, VIP and CNKI were searched to identify all case reports of HS patients undergoing AVR surgery, using different combinations of search terms "Heyde syndrome", "gastrointestinal bleeding", "aortic stenosis", and "surgery". Three authors independently extracted the clinical data including the patients' characteristics, aortic stenosis severity, gastrointestinal bleeding sites, surgical treatments and prognosis. Read More

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December 2021

Iron-Deficiency Anemia in an Elderly Caucasian Female: An Unusual Colonoscopic Finding.

Cureus 2021 Nov 14;13(11):e19564. Epub 2021 Nov 14.

Internal Medicine/Gastroenterology, Richmond University Medical Center, Staten Island, USA.

Iron-deficiency anemia (IDA) is common in the elderly population. It is usually the result of chronic gastrointestinal diseases which could lead to iron losses, malabsorption, or both. IDA is most often the result of chronic gastrointestinal blood loss caused by esophagitis, gastritis, ulcer, colon cancer, pre-malignant polyps, or angiodysplasia. Read More

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November 2021

Causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study.

Scand J Gastroenterol 2022 Feb 8;57(2):239-245. Epub 2021 Nov 8.

Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Background/aims: Causes of gastrointestinal bleeding (GIB) in patients on oral anticoagulants (OACs) are not well established. The aims of the study were to compare the causes of GIB in patients on OACs and those not on OAC therapy.

Methods: A nationwide study of all GIB events in patients on OACs in Iceland from 2014-2019 was conducted. Read More

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February 2022

Long Survival after Gastrointestinal Bleeding in a New-Onset Heyde's Syndrome Patient Treated with Multiple Endoscopic Hemostatic Procedures and Repeated Transfusions after Aortic Valve Replacement.

Case Rep Gastroenterol 2021 Sep-Dec;15(3):819-824. Epub 2021 Sep 23.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Heyde's syndrome, which is caused by aortic stenosis and subsequent acquired von Willebrand factor deficiency, is a gastrointestinal bleeding disease. Gastrointestinal bleeding develops in patients with Heyde's syndrome, which may have a different prognosis from general gastrointestinal bleeding; thus, it is important to understand the clinical course. We report a 76-year-old Japanese female who underwent aortic mechanical valve replacement 1 year ago and presented with recurrent gastrointestinal bleeding in angiodysplasia of the sigmoid colon. Read More

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September 2021

Effectiveness and predictors of response to somatostatin analogues in patients with gastrointestinal angiodysplasias: a systematic review and individual patient data meta-analysis.

Lancet Gastroenterol Hepatol 2021 11 9;6(11):922-932. Epub 2021 Sep 9.

Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, Netherlands.

Background: Gastrointestinal angiodysplasias are vascular malformations that often cause red blood cell transfusion-dependent anaemia. Several studies suggest that somatostatin analogues might decrease rebleeding rates, but the true effect size is unknown. We therefore aimed to investigate the efficacy of somatostatin analogues on red blood cell transfusion requirements of patients with gastrointestinal angiodysplasias and to identify subgroups that might benefit the most from somatostatin analogue therapy. Read More

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November 2021

The 13-year bleed: Exuberant amyloid angiopathies, angiodysplasias, and acquired coagulopathies of the gut.

SAGE Open Med Case Rep 2021 1;9:2050313X211040018. Epub 2021 Sep 1.

Department of Gastroenterology, West Palm Beach Veterans Affairs Medical Center, West Palm Beach, FL, USA.

Amyloidosis is a disorder characterized by extracellular deposits of proteins that are prone to aggregate and form insoluble fibrils. Amyloid deposits limited to a single organ or tissue without the involvement of any other site in the body is uncommon. We report a 75-year-old man with previously treated non-Hodgkin's lymphoma who presented with recurrent gastrointestinal hemorrhage. Read More

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September 2021

Heyde's Syndrome: Therapeutic Strategies and Long-Term Follow-Up.

Arq Bras Cardiol 2021 09;117(3):512-517

Instituto do Coração do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP - Brasil.

Background: Heyde's syndrome is the association of severe aortic stenosis with episodes of gastrointestinal bleeding due to angiodysplastic lesion. Little is known about the factors associated with new episodes of bleeding and long-term outcomes. Furthermore, most data are restricted to case reports and small case series. Read More

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September 2021

Diagnosis and treatment of malignant-appearing arteriovenous malformation.

Proc (Bayl Univ Med Cent) 2021 Feb 5;34(3):399-400. Epub 2021 Feb 5.

Division of Gastroenterology, Department of Medicine, Baylor Scott and White Medical Center - TempleTempleTexas.

Arteriovenous malformations (AVM) are most commonly found in the gastrointestinal tract, and presentation can range from asymptomatic to massive gastrointestinal hemorrhage. This case highlights a unique presentation of AVMs. During a screening colonoscopy, a 5-cm mass was discovered in the transverse colon encompassing 25% to 50% of the circumference of the lumen. Read More

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February 2021

Gastric antral vascular ectasia in children, rare presentation.

BMJ Case Rep 2020 Nov 30;13(11). Epub 2020 Nov 30.

Mater Dei Hospital, Msida, Malta.

A 14-year-old boy, a known case of perinatal hypoxic cerebral palsy, presented to paediatric emergency with acute melaena and blood staining around feeding gastrostomy site. Physical examination revealed pallor, but no signs of distress with an unremarkable abdominal examination. Routine blood tests revealed normochromic. Read More

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November 2020

Diffuse telangiectasia of the colon: A case report.

Medicine (Baltimore) 2020 Aug;99(34):e21106

Gastroenterology and Center of Digestive Endoscopy.

Rationale: Colonic telangiectasia, also known as colonic angiodysplasia, refers to arteriovenous malformations that occur in the colon, which are common vascular lesions in the GI tract.

Patient Concerns: We report a patient, who was admitted to our hospital for colonoscopy.

Diagnoses: Under a microscope, all the segments of the whole colon and the varicose veins showed multiple flaky spider-like telangiectasia changes. Read More

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Arteriovenous malformation that caused prolapse of the colon and was treated surgically in an infant: a case report.

Surg Case Rep 2020 Apr 8;6(1):67. Epub 2020 Apr 8.

Department of Pediatric Surgery, Kanazawa Medical University, Ishikawa, Japan.

Background: Various terms have been used to describe vascular lesions in the intestine, including angiodysplasia, arteriovenous malformation, and telangiectasia. Such lesions are common in adults and are typified by angiodysplasia, a type of arteriovenous malformation. In contrast, these lesions are rarely seen in the pediatric population. Read More

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Mutations in RPSA and NKX2-3 link development of the spleen and intestinal vasculature.

Hum Mutat 2020 01 23;41(1):196-202. Epub 2019 Sep 23.

Department of Clinical Genetics and GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.

Idiopathic intestinal varicosis is a developmental disorder defined by dilated and convoluted submucosal veins in the colon or small bowel. A limited number of families with idiopathic intestinal varices has been reported, but the genetic cause has not yet been identified. We performed whole-exome and targeted Sanger sequencing of candidate genes in five intestinal varicosis families. Read More

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January 2020

Arteriovenous malformations within jejunal diverticulosis: case report and literature review.

BMC Surg 2019 Jun 27;19(1):70. Epub 2019 Jun 27.

Department of General Surgery and Urology, Faculty of Medicine, Jordan University of Science & Technology, P. O. Box: 3030, Irbid, 22110, Jordan.

Background: Jejunal diverticula are the rarest of all small bowel diverticula. Most patients with jejunal diverticula are asymptomatic. Major complications include diverticulitis, gastrointestinal hemorrhage, intestinal obstruction and perforation. Read More

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Multiple venous malformations in the left colon and rectum: a long-standing case managed conservatively and an update of current literature.

BMJ Case Rep 2019 Mar 21;12(3). Epub 2019 Mar 21.

Gastroenterology, University Hospital of Wales, Cardiff, UK.

Venous or cavernous malformations of the colon or rectum are a rare cause of lower gastrointestinal bleeds. It has been previously described as a diffuse cavernous haemangioma which was thought to be a benign vascular tumour. It mainly affects the rectosigmoid area of the gastrointestinal tract and is most common in children and young adults. Read More

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Same-day colon capsule endoscopy is a viable means to assess unexplored colonic segments after incomplete colonoscopy in selected patients.

United European Gastroenterol J 2018 Dec 15;6(10):1556-1562. Epub 2018 Sep 15.

Trinity Academic Gastroenterology Group, Trinity College Dublin & Tallaght University Hospital, Dublin, Ireland.

Background: Same-day colon capsule endoscopy (CCE) immediately following incomplete optical colonoscopy (OC) would have a number of advantages for patients, while also presenting unique procedural challenges including the effect of sedation on capsule propulsion and patient tolerance of protracted preparation and fasting.

Aim: The aim of this article is to prospectively assess the efficacy of same-day CCE after incomplete OC in an unselected patient cohort.

Methods: This was an observational, prospective, single-centre study of CCE post-incomplete colonoscopies. Read More

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December 2018

Clinical characteristics and risk factors of active bleeding in colonic angiodysplasia among the Taiwanese.

J Formos Med Assoc 2019 May 19;118(5):876-882. Epub 2018 Oct 19.

Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Taiwan Association for the Study of Small Intestinal Diseases, Taoyuan, Taiwan. Electronic address:

Background: Colonic angiodysplasia (AGD) is a common cause of gastrointestinal bleeding. However, information on the characteristics and prevalence of colonic AGD is limited. We determined the clinical features of and risk factors for active bleeding in colonic AGD in a Taiwanese population. Read More

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Locations and Mucosal Lesions Responsible for Major Gastrointestinal Bleeding in Patients on Warfarin or Dabigatran.

Dig Dis Sci 2018 07 27;63(7):1878-1889. Epub 2018 Mar 27.

Department of Gastroenterology and Hepatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background And Aim: Different oral anticoagulants may be associated with gastrointestinal bleeding (GIB) from different locations or mucosal lesions. We aimed to test this hypothesis.

Methods: Two blinded gastroenterologists independently analyzed source documents from the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial of dabigatran 150 mg BID (D150), dabigatran 110 mg BID (D110) versus warfarin in non-valvular atrial fibrillation (NVAF). Read More

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Colonic angiodysplasia on CT colonography: case report and characteristic imaging findings.

Radiol Case Rep 2017 Dec 14;12(4):693-696. Epub 2017 Aug 14.

Department of Diagnostic and Interventional Radiology, Molecular Imaging and Radiotherapy, PTV Foundation, "Tor Vergata" University of Rome, Viale Oxford 81, 00133 Rome, Italy.

Gastrointestinal angiodysplasia represents the cause of 6% of lower gastrointestinal tract bleeding, particularly in the elderly. Because of the common presentation and age range of affected patients, often patients with occult or massive gastrointestinal bleedings are investigated with colonoscopy, in the suspect of colonic cancer. Other methods are capsule enteroscopy, angiography, double-contrast barium enema, computed tomography angiography, and radionuclide scanning. Read More

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December 2017

Lenalidomide as a novel therapy for gastrointestinal angiodysplasia in von Willebrand disease.

Haemophilia 2018 Mar 15;24(2):278-282. Epub 2018 Feb 15.

Georgetown University, Washington, DC, USA.

Introduction: Lenalidomide is a thalidomide analog with anti-angiogenic properties. Previous case reports suggest its efficacy in preventing gastrointestinal bleeding (GIB) secondary to angiodysplasia (AD) in hereditary haemorrhagic telangiectasia and potentially in reversing AD. We present the first case series to explore lenalidomide as a treatment for AD-related GIB in patients with von Willebrand disease (VWD). Read More

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Management of Acute Gastrointestinal Bleed.

Crit Care Nurs Clin North Am 2018 Mar 21;30(1):55-66. Epub 2017 Nov 21.

Austin Peay State University, School of Nursing, PO Box 4658, Clarksville, TN 37043, USA. Electronic address:

Acute gastrointestinal bleeding is a common problem found in critically ill patients that can range from self-limited bleeding to a hemorrhaging emergency. Patients can quickly develop shock and altered mental status when they develop hemodynamic instability. Therefore, it is essential that the frontline critical care nurse develop self-efficacy for management of these disorders. Read More

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Role of transesophageal echocardiography during left atrial appendage occlusion device closure in a patient with non-valvular atrial fibrillation and angiodysplasia of the colon.

Ann Card Anaesth 2018 Jan-Mar;21(1):88-91

Department of Cardiology, JSS Superspeciality Hospital and Medical College, JSS University, Mysore, Karnataka, India.

Atrial fibrillation is the most common arrhythmia associated with significant mortality and morbidity secondary to thrombo-embolism. To prevent this thrombo-embolism oral anticoagulation therapy is the recommended treatment. In patients with contraindications to oral anticoagulation therapy, percutaneous left atrial appendage occlusion device is indicated. Read More

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October 2018

A rare cause of recurrent intestinal obstruction.

Dig Liver Dis 2018 Feb 24;50(2):200. Epub 2017 Aug 24.

Department of General Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 277 Yanta West Road, Xi'an Shaanxi 710061, PR China. Electronic address:

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February 2018

Arteriovenous malformations of the colon: A report of two cases and review of the literature.

Caspian J Intern Med 2017 ;8(1):52-55

Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Arteriovenous malformations are one of the most common vascular disorders of the colon. Vascular disorders present as painless, high-volume rectal bleeding.

Case Presentation: This study elucidates two rare cases of vascular disorders that are diagnosed as angiodysplasia of the left colon and cavernous hemangioma of the colon and rectum. Read More

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January 2017

Evaluation of the efficacy of therapeutic endoscopy in gastrointestinal bleeding secondary to angiodysplasias.

Rev Gastroenterol Mex 2017 Jan - Mar;82(1):26-31. Epub 2016 Nov 25.

Servicio de Gastroenterología y Hepatología, Hospital Ramón y Cajal, Madrid, España.

Introduction: Gastrointestinal angiodysplasias are defined as vascular dilations that communicate capillaries and veins in the walls of the digestive tract. The clinical presentation of these lesions varies from chronic occult bleeding to severe gastrointestinal hemorrhage.

Aim: The primary aim of our study was to analyze lesion location, the efficacy of therapeutic endoscopy with argon plasma coagulation, and the factors associated with rebleeding in patients with gastrointestinal angiodysplasias. Read More

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Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.

Inflamm Bowel Dis 2016 12;22(12):2824-2839

*Département de Pharmacologie and de Toxicologie, University of Lausanne, Lausanne, Switzerland; Sumedha Malsure is now with the Elanco Animal Health, Basel, Switzerland; and †Institut Universitaire de Pathologie, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

Background: Inflammatory bowel diseases (IBD) including ulcerative colitis and Crohn's disease are diseases with impaired epithelial barrier function. We aimed to investigate whether mutated prostasin and thus, reduced colonic epithelial sodium channel activity predisposes to develop an experimentally dextran sodium sulfate (DSS)-induced colitis.

Methods: Wildtype, heterozygous (fr/+), and homozygous (fr/fr) prostasin-mutant rats were treated 7 days with DSS followed by 7 days of recovery and analyzed with respect to histology, clinicopathological parameters, inflammatory marker mRNA transcript expression, and sodium transporter protein expression. Read More

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December 2016

Risk factors for active bleeding from colonic angiodysplasia confirmed by colonoscopic observation.

Int J Colorectal Dis 2016 Dec 5;31(12):1869-1873. Epub 2016 Sep 5.

Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-8602, Japan.

Purpose: Colonic angiodysplasia is an important cause of lower gastrointestinal bleeding in the elderly. Here, we investigated the risk factors for bleeding from colonic angiodysplasia seen at endoscopy.

Methods: We conducted a retrospective case-control study by reviewing records of 435 patients with angiodysplasia at colonoscopy from November 2006 to November 2015 in our hospital. Read More

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December 2016

Evaluation of iron deficiency anaemia for gastrointestinal causes in patients without GI symptoms in high prevalent GI malignancy zones.

Arab J Gastroenterol 2016 Jun 11;17(2):67-72. Epub 2016 Jul 11.

Department of Medicine, GMC, Srinagar, J&K, India.

Background And Study Aims: Gastric cancer is highly prevalent in Kashmir, as are lower gastrointestinal (LGI) malignancies. Colonic cancer, gastric cancer, and coeliac disease are the most important gastrointestinal (GI) causes of iron deficiency anaemia (IDA) worldwide. Approximately 9% of patients with IDA present with a suspicious lesion in the GI tract upon examination. Read More

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Gastrointestinal bleeding due to angiodysplasia in patients on hemodialysis: A single-center study.

Saudi J Kidney Dis Transpl 2016 Jul-Aug;27(4):748-51

Department of Nephrology-Dialysis, Military Hospital Mohammed V, Rabat, Morocco.

Gastrointestinal (GI) bleeding due to angiodysplastic lesions is a common problem among patients receiving hemodialysis (HD). We studied 22 HD patients (5 females and 17 males) who had GI bleeding due to angiodysplasia; the mean age of whom was 54 ± 10 years. All patients had upper and lower GI endoscopy. Read More

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