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    Management of Persistent Angina After Myocardial Infarction Treated With Percutaneous Coronary Intervention: Insights From the TRANSLATE-ACS Study.
    J Am Heart Assoc 2017 Oct 19;6(10). Epub 2017 Oct 19.
    Division of Cardiology, Duke University, Durham, NC.
    Background: Angina has important implications for patients' quality of life and healthcare utilization. Angina management after acute myocardial infarction (MI) treated with percutaneous coronary intervention (PCI) is unknown.

    Methods And Results: TRANSLATE-ACS (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) was a longitudinal study of MI patients treated with percutaneous coronary intervention at 233 US hospitals from 2010 to 2012. Read More

    Prevalence of Single and Multiple Leading Causes of Death by Race/Ethnicity Among US Adults Aged 60 to 79 Years.
    Prev Chronic Dis 2017 Oct 19;14:E101. Epub 2017 Oct 19.
    Department of Pharmacy Practice, Daniel K. Inouye College of Pharmacy at the University of Hawai'i at Hilo, Hilo, Hawai'i.
    Introduction: Diabetes, cancer, cardiovascular disease (CVD) (coronary artery disease, heart attack, and angina pectoris), and chronic lung disease (emphysema, chronic bronchitis, and chronic obstructive pulmonary disease) are major causes of death in the United States. The objective of this study was to assess racial/ethnic differences in the prevalence of these conditions as cause of death among people aged 60 to 79 years with one or more of these conditions.

    Methods: We used data on the prevalence of major chronic conditions from the National Health Interview Survey on 56,290 adults aged 60 to 79 years who reported having any of the chronic conditions assessed in the National Health Interview Survey for 2006 through 2014. Read More

    Comparison of circulating dendritic cell and monocyte subsets at different stages of atherosclerosis: insights from optical coherence tomography.
    BMC Cardiovasc Disord 2017 Oct 18;17(1):270. Epub 2017 Oct 18.
    Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
    Background: While specific patterns of circulating dendritic cells (DCs) and monocytes are associated with the incidence of coronary artery disease, the characterization of circulating DC and monocyte subsets in patients with different stages of atherosclerosis remains unclear.

    Methods: Forty-eight patients with unstable angina pectoris (UAP) diagnosed by angiography were enrolled. Likewise, 31 patients with ST-segment elevation myocardial infarction (STEMI) were enrolled and confirmed with the presence of thrombosis by angiography. Read More

    [Optimal Diagnostics and Therapy for Microvascular Angina Pectoris].
    Dtsch Med Wochenschr 2017 Oct 18;142(21):1586-1593. Epub 2017 Oct 18.
    Patients with microvascular angina are characterized by angina pectoris with proof of myocardial ischemia in the absence of any relevant epicardial stenosis and without myocardial disease (type 1 coronary microvascular dysfunction according to Crea and Camici). Structural and functional alterations of the coronary microvessels (diameter < 500 µm) are the reason for this phenomenon. Frequently such alterations are associated with cardiovascular risk factors. Read More

    Males with prolactinoma are at increased risk of incident cardiovascular disease.
    Clin Endocrinol (Oxf) 2017 Oct 16. Epub 2017 Oct 16.
    Institute of Applied Health Research, University of Birmingham, B15 2TT, Birmingham, UK.
    Objective: To investigate whether the risk of incident cardiovascular disease (CVD) is increased in patients with prolactinoma.

    Design: Population-based, retrospective, open-cohort study using The Health Improvement Network (THIN) database.

    Patients: 2,233 patients with prolactinoma and 10,355 matched controls (1:5 ratio) from UK General Practices contributing to THIN were included. Read More

    Angina in granulomatosis with polyangiitis: A case report.
    Exp Ther Med 2017 Oct 16;14(4):3569-3572. Epub 2017 Aug 16.
    Department of Cardiology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
    Granulomatosis with polyangiitis (GPA) often causes small blood vessel lesions in multiple organs, with less impact on large vessels. We report a case involving not only large blood vessels, but also angina. The computed tomographic angiography of large vessels and vascular ultrasonography of the extremity also suggested great arteries of the body were involved. Read More

    Effect of Elective Percutaneous Coronary Intervention on Hyperemic Absolute Coronary Blood Flow Volume and Microvascular Resistance.
    Circ Cardiovasc Interv 2017 Oct;10(10)
    From the Department of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Japan (Y.K., T.M., T.Y., E.U., M.A., J.M., M.H., M.Y., T.N., M.H., S.I., R.H., Y.K., T.K.) and Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Japan (M.I.).
    Background: The hemodynamics involved in the relationship between absolute coronary blood flow (ABF) volume and myocardial resistance (MR) are complex, and the effect of percutaneous coronary intervention (PCI) on their changes remains unclear. The aim of this study was to investigate the differences in hyperemic ABF and MR before and after elective PCI using a thermodilution method.

    Methods And Results: We investigated 28 vessels (right coronary artery, 9; left anterior descending coronary artery, 18; left circumflex coronary artery, 1) from 28 patients with stable angina pectoris undergoing elective PCI. Read More

    Obstructive coronary artery disease in patient with acute thrombotic thrombocytopenic purpura.
    BMJ Case Rep 2017 Oct 15;2017. Epub 2017 Oct 15.
    Division of Cardiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
    Thrombotic thrombocytopenic purpura (TTP) affects essentially all organ systems. Myocardial injury in TTP is often attributed to microthrombi formation. We present the first case report in the literature of an acute TTP patient with concomitant obstructive coronary artery disease (CAD) and acute myocardial infarction who underwent successful percutaneous coronary intervention (PCI). Read More

    Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need.
    Heart 2017 Oct 13. Epub 2017 Oct 13.
    British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
    The diagnostic management of patients with angina pectoris typically centres on the detection of obstructive epicardial CAD, which aligns with evidence-based treatment options that include medical therapy and myocardial revascularisation. This clinical paradigm fails to account for the considerable proportion (approximately one-third) of patients with angina in whom obstructive CAD is excluded. This common scenario presents a diagnostic conundrum whereby angina occurs but there is no obstructive CAD (ischaemia and no obstructive coronary artery disease-INOCA). Read More

    Intermediate and nonclassical monocytes show heterogeneity in patients with different types of acute coronary syndrome.
    Cytometry A 2017 Oct 11. Epub 2017 Oct 11.
    Department of Internal Medicine, Zuyderland Medical Center, Sittard, The Netherlands.
    This study was performed to gain further insight in the heterogeneity of monocytes in the different categories of acute coronary syndrome (ACS), especially between patients with unstable angina pectoris, ST-elevation myocardial infarction (STEMI), and non-ST-elevation myocardial infarction (NSTEMI). For this purpose, blood samples were collected in the acute phase from patients presenting with an ACS. These samples were examined with multiparameter flow cytometry to identify the different monocyte subsets and to analyze the expression of monocyte-associated molecules. Read More

    Effect of sex difference in clinical presentation (stable coronary artery disease vs unstable angina pectoris or non-ST-elevation myocardial infarction vs ST-elevation myocardial infarction) on 2-year outcomes in patients undergoing percutaneous coronary intervention.
    J Interv Cardiol 2017 Oct 11. Epub 2017 Oct 11.
    Centre for Coronary Heart Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Objective: To determine whether there is a difference in 2-year prognosis among patients across the spectrum of coronary artery disease undergoing percutaneous coronary intervention (PCI).

    Methods: We analyzed all consecutive patients undergoing PCI at a single center from 1/1-12/31/2013. Clinical presentations were compared between sexes according to baseline clinical, angiographic, and procedural characteristics and 2-year (mean 730 ± 30-day) outcomes. Read More

    Blood pressure targets for the treatment of people with hypertension and cardiovascular disease.
    Cochrane Database Syst Rev 2017 Oct 11;10:CD010315. Epub 2017 Oct 11.
    Drug Prescribing Service, Navarre Health Service, Plaza de la Paz, s/n, 7th floor, Pamplona, Navarre, Spain, 31002.
    Background: Hypertension is a prominent preventable cause of premature morbidity and mortality. People with hypertension and established cardiovascular disease are at particularly high risk, so reducing blood pressure below standard targets may be beneficial. This strategy could reduce cardiovascular mortality and morbidity but could also increase adverse events. Read More

    The Reducer device in patients with angina pectoris: mechanisms, indications, and perspectives.
    Eur Heart J 2017 Aug 31. Epub 2017 Aug 31.
    Department of Cardiology, Tel-Aviv Medical Center, Tel-Aviv, Israel and the Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel.
    Despite available pharmacological and interventional therapies, refractory angina is a common and disabling clinical condition, and a major public health problem, which affects patients' quality-of-life, and has a significant impact upon health care resources. Persistent angina is common not only in patients who are not good candidates for revascularization, but also in patients following successful revascularization. Clearly, there is a need for additional treatment options for refractory angina beyond currently available pharmacological and interventional therapies. Read More

    Cognitive changes in prevalent and incident cardiovascular disease: a 12-year follow-up in the Maastricht Aging Study (MAAS).
    Eur Heart J 2017 Jul 22. Epub 2017 Jul 22.
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Alzheimer Centre Limburg, Maastricht University, Dr Tanslaan 12, PO Box 616 (DRT 12), 6200 MD, Maastricht, The Netherlands.
    Aims: Cardiovascular disease (CVD) has been suggested to accelerate cognitive decline and to be a risk factor for dementia, but still little is known about the cognitive course after a first cardiovascular event. Therefore, the present study aims to investigate the cognitive trajectories in both prevalent and incident CVD over a 12-year time period in the general population.

    Methods And Results: Cognitively healthy participants (age 24-82 years, n = 1823) of a prospective cohort study were serially assessed at baseline, 6 and 12 years. Read More

    Social inequality and barriers to cardiac rehabilitation in the rehab-North register.
    Scand Cardiovasc J 2017 Oct 11:1-7. Epub 2017 Oct 11.
    a Department of Cardiology , Aalborg University Hospital , Aalborg , Denmark.
    Aim: Barriers to participation in cardiac rehabilitation (CR) may occur at three levels of the referral process (lack of information, declining to participate, and referral to appropriate CR programme). The aim is to analyse the impact of socioeconomic status on barriers to CR and investigate whether such barriers influenced the choice of referral.

    Methods: The Rehab-North Register, a cross-sectional study, enrolled 5455 patients hospitalised at Aalborg University Hospital with myocardial infarction (MI) during 2011-2014. Read More

    Circulating adipocyte fatty acid-binding protein is a predictor of cardiovascular events in patients with stable angina undergoing percutaneous coronary intervention.
    BMC Cardiovasc Disord 2017 Oct 10;17(1):258. Epub 2017 Oct 10.
    Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
    Background: Adipocyte fatty acid-binding protein (A-FABP) is expressed in both adipocytes and macrophages. Recent studies have shown that A-FABP is secreted by adipocytes and that the A-FABP concentration is associated with obesity, insulin resistance, and atherosclerosis. We have reported that the coronary atherosclerotic burden is associated with the serum A-FABP concentration. Read More

    Absence of adventitial vasa vasorum formation at the coronary segment with myocardial bridge - An optical coherence tomography study.
    Int J Cardiol 2017 Oct 4. Epub 2017 Oct 4.
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. Electronic address:
    Background: Myocardial bridge (MB) is a myocardial bundle through which coronary segment tunnels and could compress coronary arteries causing myocardial ischemia. However, the characteristic structural findings of MB remain to be fully elucidated. Recently, we demonstrated that optical coherence tomography (OCT) enables us to visualize adventitial vasa vasorum (VV) formation in humans. Read More

    Predictive value of depression and anxiety for long-term mortality: differences in outcome between acute coronary syndrome and stable angina pectoris.
    Int J Cardiol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands; Research Institute of Child Development and Education, University of Amsterdam/de Bascule-AMC, The Netherlands.
    Background: Since the early 2000s the treatment of choice for an acute myocardial infarction has moved from thrombolytic therapy to primary PCI (pPCI). As a result, the majority of patients undergoing PCI shifted from stable angina pectoris (SA) to acute coronary syndrome (ACS). Additionally the previously observed association between depression and anxiety and long-term outcome in patients who underwent a PCI may have been changed. Read More

    Influence of coronary calcification patterns on hemodynamic outcome of coronary stenoses and remodeling.
    Turk Kardiyol Dern Ars 2017 Oct;45(7):606-613
    Department of Cardiology, Istanbul University Faculty of Medicine, İstanbul, Turkey.
    Objective: The histological characteristics of plaque may affect the hemodynamic outcome of a given coronary stenosis. In particular, the potential effect of volumetric calcium content and the topographical distribution in the lesion segment on physiological outcome has not yet been investigated. The aim of this study was to identify any potential correlation between patterns of calcification and the fractional flow reserve (FFR) and the coronary remodeling index (RMI). Read More

    Basic in vitro Characterization of the Vasodilatory Potential of 2-Aminoethyl Nitrate Fixed-Dose Combinations with Cilostazol, Metoprolol and Valsartan.
    Pharmacology 2017 Oct 7;101(1-2):54-63. Epub 2017 Oct 7.
    Center for Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany.
    Background/aims: 2-aminoethyl nitrate (CLC-1011) is a member of the class of organic nitrates that cause vasodilation by the generation of nitric oxide (•NO). These drugs are mainly used for the treatment of angina pectoris and ischemic heart disease. The aim of this study was to characterize the vasodilatory potency of this organic nitrate alone and in combination with clinically established cardiovascular drugs. Read More

    Health-related quality of life in older patients with acute coronary syndrome randomised to an invasive or conservative strategy. The After Eighty randomised controlled trial.
    Age Ageing 2017 Jul 13:1-7. Epub 2017 Jul 13.
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
    Objective: in the After Eighty study (, NCT01255540), patients aged 80 years or more, with non-ST-elevation myocardial infarction (NSTEMI), and unstable angina pectoris (UAP), were randomised to either an invasive or conservative management approach. Read More

    Expression of matrix metalloproteinases-12 in ST-segment elevation myocardial infarction: A case-control study.
    Medicine (Baltimore) 2017 Oct;96(40):e8035
    Laboratory of Molecular Cardiology, Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China.
    Matrix metalloproteinases-12 (MMP12) can lead to degradation of elastin resulting in plaque destabilization and rupture. MMP12 also facilitates platelet aggregation, adhesion, and granule secretion. However, evidence in the literature related to the function of MMP12 in ST-segment elevation myocardial infarction (STEMI) is little. Read More

    Effect of nicorandil on QT dispersion in patients with stable angina pectoris undergoing elective angioplasty: A triple-blind, randomized, placebo-controlled study.
    Electron Physician 2017 Aug 25;9(8):4934-4941. Epub 2017 Aug 25.
    M.D., Resident of Cardiology, Department of Cardiology, Faculty of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
    Background: Nicorandil leads to the relaxation of fine vascular smooth muscle, and thus causes vasodilatation of major epicardial. Also, it has anti-arrhythmic and cardio-protective effects by improving reperfusion, and ultimately leads to a reduction in microvascular damage caused by percutaneous coronary intervention (PCI).

    Objective: The aim of this study was to determine the effect of nicorandil on QT interval dispersion (QTd) in patients with stable angina pectoris during elective angioplasty. Read More

    Cardiopulmonary Exercise Test.
    Int Heart J 2017 Sep 30. Epub 2017 Sep 30.
    Department of Cardiology, Gunma Prefectural Cardiovascular Center.
    The cardiopulmonary exercise test (CPX) is an essential examination for detecting pathophysiological derangement and determining treatment policy because it clarifies not only the changes of hemodynamics but also abnormality in the whole body during exercise where heart disease patients often feel symptoms.To utilize CPX effectively, we must understand each parameter, such as peak oxygen uptake (peak VO2), peak VO2/HR, and VE/VCO2. In addition, comparison of each parameter, for example, peak VO2 and VE/VCO2, and peak VO2 and peak VO2/HR, is useful to detect the pathophysiological abnormalities. Read More

    Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism.
    J Physiol Sci 2017 Sep 30. Epub 2017 Sep 30.
    Poznan University of Life Sciences, ul. Wojska Polskiego 31, 62-624, Poznan , Poland.
    A number of studies have reported that zinc plays a substantial role in the development of metabolic syndrome, taking part in the regulation of cytokine expression, suppressing inflammation, and is also required to activate antioxidant enzymes that scavenge reactive oxygen species, reducing oxidative stress. Zinc also plays a role in the correct functioning of lipid and glucose metabolism, regulating and forming the expression of insulin. In numerous studies, zinc supplementation has been found to improve blood pressure, glucose, and LDL cholesterol serum level. Read More

    [Treatment of cardiovascular disease with Xiongshao capsule].
    Zhongguo Zhong Yao Za Zhi 2017 Feb;42(4):640-643
    Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
    Cardiovascular diseases have the characteristics of high morbidity and high mortality, and are recognized as the first cause of death by World Health Organization in World Health Statistics 2016. In recent years, traditional Chinese medicines have been widely applied in the treatment of cardiovascular diseases, while studies for integrated traditional Chinese and western medicines for treating cardiovascular diseases have made a great progress. Xiongshao capsule was developed by Academician Chen Keji according to classic formula Xuefu Zhuyu decoction and composed of effective parts of Rhizoma Ligusticum Wallichii and Radix Paeonia Rubra, with remarkable therapeutic effects on angina pectoris, restenosis after percutaneous coronary intervention(PCI), atherosclerosis, dyslipidemia and so on. Read More

    Association of Epicardial, Visceral, and Subcutaneous Fat With Cardiometabolic Diseases.
    Circ J 2017 Sep 27. Epub 2017 Sep 27.
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University.
    Background: Excess of visceral fat is a central factor in the pathogenesis of metabolic syndrome (MetS) and atherosclerosis. However, little is known about how much epicardial fat affects cardiometabolic disorders in comparison with visceral or subcutaneous fat.Methods and Results:Participants suspected as having angina pectoris underwent cardiac computed tomography (CT) imaging. Read More

    The European Collaborative Project on Inflammation and Vascular Wall Remodeling in Atherosclerosis - Intravascular Ultrasound (ATHEROREMO-IVUS) Study.
    EuroIntervention 2017 Sep 26. Epub 2017 Sep 26.
    The Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands.
    Aims: The European Collaborative Project on Inflammation and Vascular Wall Remodelling in Atherosclerosis - Intravascular Ultrasound (ATHEROREMO-IVUS) study has been designed as an exploratory clinical study to investigate the associations between genetic variation, coronary atherosclerosis phenotypes, and plaque vulnerability as determined by IVUS.

    Methods And Results: The ATHEROREMO-IVUS study is a prospective, observational study of 581 patients with stable angina pectoris or acute coronary syndrome (ACS) who were referred for coronary angiography to the Thoraxcenter, Rotterdam, enriched with 265 IBIS-2 participants (total population, n=846). Prior to catheterization, blood samples were drawn for genetic analyses. Read More

    Peripheral Endothelial Function and Coronary Flow Velocity Reserve Are Not Associated in Women with Angina and No Obstructive Coronary Artery Disease: The iPOWER Study.
    J Vasc Res 2017 23;54(5):309-319. Epub 2017 Sep 23.
    Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark.
    Purpose: We investigated whether impaired flow-mediated dilation (FMD) and plasma biomarkers reflecting endothelial dysfunction are associated with coronary microvascular dysfunction (CMD) in women with angina and no obstructive coronary artery disease (CAD).

    Methods: Patients (n = 194) were randomly selected women with angina pectoris and no obstructive CAD (<50% stenosis). A reference population of asymptomatic women without CAD (n = 25) was included. Read More

    Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction.
    J Electrocardiol 2017 Aug 17. Epub 2017 Aug 17.
    Department of Cardiology, Odense University Hospital, University of Southern Denmark, Denmark.
    Objectives: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD.

    Methods: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. Read More

    [Angina Pectoris in a Young Woman with Lupus Erythematosus].
    Dtsch Med Wochenschr 2017 Sep 22;142(19):1449-1452. Epub 2017 Sep 22.
    Klinik III für Innere Medizin, Herzzentrum, Universität zu Köln, Köln.
    History and clinical findings We present a 31-year old woman with a 6-year history of cutaneous lupus erythematosus (CLE) who presented to the emergency room with typical chest pain. ECG and transthoracic echocardiography were normal. Her working diagnosis of pericarditis was made due to systemic progression of her lupus erythematosus (LE). Read More

    [Mechanism of Salvianolate injection combined with aspirin in treatment of stable angina pectoris based on biomolecules network].
    Zhongguo Zhong Yao Za Zhi 2016 Dec;41(24):4521-4532
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
    Biomolecular network analysis was used to predict the mechanism of Salvianolate injection combined with aspirin for the treatment of stable angina pectoris(SAP). Related genes of Salvianolate injection, aspirin and SAP were obtained from Genecards, STITCH and DisGeNET databases. Agilent literature search software was used to construct biomolecular network; modules were identified by AP, MCODE and MCL methods. Read More

    [Efficacy and safety of smiltiorrhizadepsidesal combined with conventional western medicine treatment for stable angina pectoris].
    Zhongguo Zhong Yao Za Zhi 2016 Dec;41(24):4488-4493
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
    In recent years, Chinese patent medicines such as smiltiorrhizadepsidesal(SMDS) injection are combined with western medicine to achieve good clinical efficacy for stable angina pectoris(SAP). SMDS is prepared by the water-soluble active ingredients extracted from Salvia miltiorrhiza, with the functions of promoting blood circulation, removing blood stasis and activating blood vessels, and it is used to treat type ⅠSAP and type ⅡSAP. The efficacy and safety of SMDS combined with simple routine western medicine for SAP were investigated by searching PubMed, EMbase, the Cochrane Library, CNKI, VIP, WanFang Data and CBM Database. Read More

    Off-Pump Double Coronary Artery Bypass in a 14-Year-Old With Kawasaki Disease.
    Ann Thorac Surg 2017 Oct;104(4):e307-e309
    Department of Surgery, University of California, San Francisco-Fresno, Fresno, California; St. Agnes Medical Centre, Fresno, California. Electronic address:
    A 14-year-old male patient with a history of atypical Kawasaki disease at age 2 presents with triple vessel giant coronary aneurysms. Over the last several years, he began experiencing angina and dyspnea on exertion, which was a result of fully occluded right coronary and left circumflex arteries and 90% stenosis in the left anterior descending artery. He underwent off-pump coronary artery bypass using the left and right internal mammary arteries. Read More

    [Reevaluation for systematic reviews for traditional Chinese medicine injections for coronary disease].
    Zhongguo Zhong Yao Za Zhi 2016 Nov;41(22):4259-4266
    Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
    To reevaluate the systematic reviews for traditional Chinese medicine(TCM) injections for treating coronary disease, data in four Chinese databases and PubMed, Embase, Cochrane Library, Wed of Science OVID from inception until May 2016 were searched. We extracted data according to the AMSTAR and PRISMA checklists to evaluate the methodological quality and reporting characteristics of included literatures. A total of 69 systematic reviews were included, involving 24 TCM injections, which showed certain efficacy in treating coronary disease, and whose main outcome indexes included alleviation of symptoms of angina pectoris and electrocardiogram. Read More

    Association between Periodontal disease and Prostate cancer: Results of a 12-year Longitudinal Cohort Study in South Korea.
    J Cancer 2017 25;8(15):2959-2965. Epub 2017 Aug 25.
    Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.
    The incidence of prostate cancer (PC) accompanying periodontal disease (PD) is anticipated to increase due to population aging. The aim of this study was to determine the association between PD and PC using data in the National Health Insurance Service-Health Examinee Cohort (NHIS-HEC). A random stratified sample of 187,934 South Koreans was collected from the NHIS database from 2002 to 2013. Read More

    Age and composite end-point events in medium follow-up of patients with carotid artery total occlusion using drug therapy.
    Atherosclerosis 2017 Oct 6;265:184-189. Epub 2017 Sep 6.
    Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
    Background And Aims: The outcome of carotid artery total occlusion (CATO) is unclear. The aim of this study is to report the medium incidence of composite end-point events and risk factors (especially age), in patients with CATO, treated medically.

    Methods: This was a single center retrospective study. Read More

    [Preliminary investigation on mechanism of Naoxintong capsule's preventive treatment of cardio-cerebrovascular disease based on serum proteomics].
    Zhongguo Zhong Yao Za Zhi 2016 Aug;41(15):2864-2871
    Tianjin University of Traditional Chinese Medicine, Institute of Chinese Medicine, Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin 300193, China.
    Naoxintong capsule has beneficial effects for activating blood circulation, dispersing blood stasis and dredging collateral. It is widely used in the treatment of coronary heart disease, angina pectoris, stroke and cardiovascular disease. However, the pharmacodynamic basis and possible mechanism of its preventive effects are not clear. Read More

    Cardioprotective Effects of Pomegranate (Punica granatum) Juice in Patients with Ischemic Heart Disease.
    Phytother Res 2017 Sep 15. Epub 2017 Sep 15.
    Department of Physiology, The School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
    Ischemic heart disease is the leading cause of mortality worldwide. The purpose of this study was to evaluate the cardioprotective effects of pomegranate juice in patients with ischemic heart disease. One hundred patients, diagnosed with unstable angina or myocardial infarction, were randomly assigned to the test and the control groups (n = 50, each). Read More

    A Successfully Treated Case of Gastrointestinal Stromal Tumor Causing Severe Anemia and Localized Peritonitis Showing Angina Pectoris Resulting in Watershed Cerebral Infarction.
    Case Rep Med 2017 20;2017:6030561. Epub 2017 Aug 20.
    Department of Neurology, Ishibashi General Hospital, 628 Ishibashi, Shimotsuke, Tochigi 329-0596, Japan.
    Ischemic stroke following acute myocardial infarction is a rare but a serious complication. Because the pathophysiology of stroke is dynamic, it is often hard to identify the cause of stroke. Here, we present the case of a 75-year-old man with ischemic stroke following angina pectoris caused by severe anemia and localized peritonitis due to gastrointestinal stromal tumor of small intestine. Read More

    Is Corneal Arcus Independently Associated with Incident Cardiovascular Disease in Asians?
    Am J Ophthalmol 2017 Sep 11. Epub 2017 Sep 11.
    Singapore Eye Research Institute, Singapore; Duke-NUS Medical School, Singapore. Electronic address:
    Purpose: To examine the longitudinal relationship between baseline corneal arcus (CA) and incident CVD in ethnic Indian and Malay adults in Singapore.

    Design: Population-based cohort study.

    Methods: Indian and Malay adults aged 40-80 years were recruited for baseline and 6-year follow-up visits between 2004-09 and 2010-15, respectively (follow-up response rate 73. Read More

    The correlation between plasma human neutrophil peptide 1-3 levels and severity of coronary artery disease.
    Arch Med Sci Atheroscler Dis 2016 6;1(1):e133-e138. Epub 2016 Dec 6.
    Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
    Introduction: Inflammation plays a key role in atherosclerosis, and discovering new biomarkers of inflammation is becoming important in order to uncover the pathogenesis of atherosclerotic coronary artery disease (CAD). Recent studies have focused on polymorphonuclear neutrophils. It has been suggested that human neutrophil peptide 1-3 (HNP1-3) is proatherogenic. Read More

    A massive left-to-right shunt due to delayed spontaneous perforation of polyvinyl alcohol membrane of atrial septal occluder.
    Turk Kardiyol Dern Ars 2017 Sep;45(6):541-544
    Department of Cardiology, Derince Training and Research Hospital, Kocaeli, Turkey.
    Percutaneous closure of an atrial septal defect (ASD) has emerged as an alternative to surgery. A 54-yearold woman with a history of percutaneous ASD closure with a 30-mm Cardia Ultrasept septal occluder (Cardia Inc., Eagan, MN, USA) comprising 2 discs made of Nitinol wire mesh covered with polyvinyl alcohol (PVA) membrane, was admitted to the hospital with unstable angina pectoris. Read More

    Assessment of the association between the personality traits of young patients with acute coronary syndrome and the severity of coronary artery disease.
    Turk Kardiyol Dern Ars 2017 Sep;45(6):514-519
    Department of Cardiology, Antalya Training and Research Hospital, Antalya, Turkey.
    Objective: The role of psychosocial risk factors is becoming increasingly important in the etiology of acute coronary syndrome (ACS). The purpose of this study was to assess an association between the personality types of young patients with ACS and the prevalence and severity of coronary artery disease (CAD).

    Methods: Patients younger than 45 years of age who presented with ACS and who underwent coronary angiography in the period from 2012 to 2016 were included in the study. Read More

    Practice of Comparative Effectiveness Research to Identify Treatment Characteristics of Similar Chinese Patent Medicine for Angina Pectoris.
    Evid Based Complement Alternat Med 2017 13;2017:7062714. Epub 2017 Aug 13.
    Tianjin University of Traditional Chinese Medicine, Tianjin, China.
    Objective: Individualized application of TCM is not easy and may lead to undesirable results, such as poor effect or even adverse reactions. This trial aims to compare two common Chinese patent medicines with similar effects.

    Background Of The Research: Four hospitals carried out the test at the same time in Tianjin city of China. Read More

    [Redo Off-pump Coronary Artery Bypass for Postoperative Vein Graft Stenosis of Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery;Report of a Case].
    Kyobu Geka 2017 Sep;70(10):859-862
    Department of Cardiovascular Surgery, Kushiro City General Hospital, Kushiro, Japan.
    Bland-White-Garland (BWG) syndrome (anomalous origin of the left coronary artery from the pulmonary artery) is a rare disease which may result in myocardial infarction, congestive heart failure or sometimes death during the early infantile period. We present a 57-year-old female with BWG syndrome. At the age of 20, she was diagnosed with BWG syndrome and underwent coronary artery bypass grafting of a saphenous vein to the proximal portion of the anterior descending branch of the left coronary artery and ligation of the anomalous artery. Read More

    Serial 3-Vessel Optical Coherence Tomography and Intravascular Ultrasound Analysis of Changing Morphologies Associated With Lesion Progression in Patients With Stable Angina Pectoris.
    Circ Cardiovasc Imaging 2017 Sep;10(9)
    From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (M.H.Y, M.M., A.F., M.I., T.M., G.S.M., A.M.); Center for Interventional Vascular Therapy, Division of Cardiology, NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (M.H.Y, A.F., M.I., A.M.); and Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital, Japan (M.H.Y, K.Y., S.E., T.O., S.S., K.H., K.A., T.Y., N.I., H.A., C.O., M.O.).
    Background: Optical coherence tomographic (OCT) morphologies associated with lesion progression are not well studied. The aim of this study was to determine the morphological change for untreated lesion progression using both OCT and intravascular ultrasound (IVUS).

    Methods And Results: We used baseline and 8-month follow-up 3-vessel OCT and IVUS to assess 127 nonculprit lesions (IVUS plaque burden ≥40%) in 45 patients with stable angina after target lesion treatment. Read More

    A randomised controlled trial comparing venous stenting with conservative treatment in patients with deep venous obstruction: research protocol.
    BMJ Open 2017 Sep 11;7(9):e017233. Epub 2017 Sep 11.
    Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
    Introduction: Deep venous obstruction (DVO) has a great impact on quality of life (QoL) comparable to angina pectoris or chronic pulmonary disease. Post-thrombotic scar formation and May-Thurner syndrome (MTS) are the most common causes of DVO. Conventional treatment of DVO focuses on reducing pain or leg swelling by use of (pain) medication and therapeutic elastic stockings. Read More

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