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Cardiol Ther 2019 Feb 18. Epub 2019 Feb 18.

Laboratory of Biostatistics, National Medical Research Center for Preventive Medicine of the Ministry of Healthcare, Moscow, Russia.

Introduction: Trimetazidine (TMZ) has been shown to be efficacious for angina treatment. The TMZ 80-mg formulation allows one-daily (od) dosage, which could improve symptom control and adherence.

Methods: The 3-month, observational, multicenter, prospective ODA (antianginal effectiveness and tolerability of trimetazidine modified release 80 mg Once Daily in stable Angina patients in real-world practice) study assessed TMZ 80 mg od effectiveness in stable angina patients with persistent symptoms despite therapy. Read More

Int J Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China. Electronic address:

Objective: The impact of tissue characteristics of culprit lesion on myocardial tissue-level perfusion in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) remains unclear. EARLY-MYO-ACS study was a prospective observational study to investigate the relationship between pre-percutaneous coronary intervention (PCI) culprit plaque characteristics and post-PCI myocardial tissue-level perfusion with iMap intravascular ultrasound (IVUS) in NSTE-ACS patients.

Methods: A total of 408 patients with coronary artery disease (246 NSTE-ACS and 162 stable angina pectoris) undergoing coronary angiography, grayscale-IVUS and iMap-IVUS were enrolled. Read More

Am J Cardiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Medicine, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.

Greater optimism regarding recovery from chronic illness is associated with improved quality of life and clinical outcomes. We performed a post-hoc analysis on the association between optimism and outcomes in Ranolazine in Patients with Incomplete Revascularization after Percutaneous Coronary Intervention (RIVER-PCI), a randomized trial in patients with chronic angina pectoris who had incomplete revascularization following percutaneous coronary intervention. At baseline, patients answered how much they agreed with the phrase, "I am optimistic about my future and returning to a normal lifestyle. Read More

Am Heart J 2019 Jan 15;210:98-107. Epub 2019 Jan 15.

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP), Department of Cardiology, Paris, France; Université Paris-Descartes, Paris, France; INSERM U-970, Paris, France.

Background: About 30% of angina patients have persisting symptoms despite successful revascularization and antianginal therapy. Moreover, in stable patients, percutaneous coronary intervention (PCI) does not improve survival as compared with medical therapy alone. Trimetazidine, an antianginal agent devoid of hemodynamic effect, may help reducing symptoms and improving outcomes after PCI. Read More

Biosci Rep 2019 Feb 15. Epub 2019 Feb 15.

Beijing University of Chinese Medicine, Beijing, China

Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the diagnosis, prognosis, and treatment of UA remains a challenge in the clinic. A global metabolomics research based on ultra performance liquid chromatography (UPLC) combined with time of flight mass spectrometry (Q-TOF/MS) was performed to discover the metabolic profile of health controls, UA patients, and UA patients with diabetes mellitus (DM), and screen for potential biomarkers. Read More

Proc Jpn Acad Ser B Phys Biol Sci 2019 ;95(2):53-66

Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute.

Coronary artery spasm (CAS) plays an important role in the pathogenesis of ischemic heart disease, including angina pectoris, myocardial infarction, and sudden death, occurring most often from midnight to early morning. CAS is prevalent among East Asians and is associated with an aldehyde dehydrogenase 2 (ALDH2)-deficient genotype (ALDH2*2) and alcohol flushing, which is prevalent among East Asians but is virtually non-existent in other populations. ALDH2 eliminates not only acetaldehyde but also other toxic aldehydes from lipid peroxidation and tobacco smoking, thereby protecting tissues and cells from oxidative damage. Read More

Front Cardiovasc Med 2019 22;6. Epub 2019 Jan 22.

Stavanger University Hospital Department of Cardiology, Stavanger, Norway.

Our aim was to automatically estimate the blood velocity in coronary arteries using cine X-ray angiographic sequence. Estimating the coronary blood velocity is a key approach in investigating patients with angina pectoris and no significant coronary artery disease. Blood velocity estimation is central in assessing coronary flow reserve. Read More

Klin Lab Diagn 2018 ;63(8):471-477

Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, 625026, Tomsk, Russia.

The study of the causes of the development of vascular coronary complications after angioplasty with stenting using the evaluation of biochemical parameters in the dynamic observation of patients with IHD with significant coronary stenosis determines the relevance of the study. To analyze the parameters of lipid spectrum and markers of vascular inflammatory reaction in patients with IHD, in groups with stable angina and episode of unstable angina after angioplasty with stenting, to trace the dynamics of biochemical parameters and to reveal the predictors of undesirable coronary events. Patients with IHD with significant coronary stenosis of the arteries (SCS, n = 95) after coronary angiography at the point of maximum increase in the level of markers of the inflammatory reaction (3 months after angioplasty) are divided into 2 groups - patients with persistent stable angina pectoris (SA, n = 77) until the end of the study and patients with developed postvascularization episode of unstable angina (UA, n = 18). Read More

Eur J Pharmacol 2019 Feb 1;849:50-58. Epub 2019 Feb 1.

Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha 410013, China. Electronic address:

Methyl protodioscin (MPD) is reported to relieve angina pectoris and myocardial ischemia, and mitochondrial E3 ubiquitin ligase 1 (Mul1) plays a key role in maintaining mitochondrial functions. Bioinformatic analysis shows potential interactions between MPD and Mul1. This study aims to explore whether MPD could protect rat brain against ischemia/reperfusion (I/R) injury through regulation of Mul1/ superoxide dismutase 2 (SOD2) pathway. Read More

Complement Ther Clin Pract 2019 Feb 24;34:247-253. Epub 2018 Dec 24.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medicine University, Nanjing, China. Electronic address:

Background And Purpose: Stable angina pectoris is a common symptom imperiling patients' life quality. The purpose of this meta-analysis is to assess the effectiveness of acupuncture alone or acupuncture plus medicine for the treatment of stable angina pectoris.

Methods: Seven databases were searched ranging from 1959 to February 2018. Read More

J Emerg Med 2019 Jan 30. Epub 2019 Jan 30.

SAMU 78, Centre Hospitalier de Versailles, André Mignot, Le Chesnay, France.

Background: Recent-onset atrial fibrillation (RAF) is the most frequent supraventricular dysrhythmia in emergency medicine. Severely compromised patients require acute treatment with injectable drugs OBJECTIVE: The main purpose of this external validity study was to compare the short-term efficacy of esmolol with that of amiodarone to treat severe RAF in an emergency setting.

Methods: This retrospective survey was conducted in mobile intensive care units by analyzing patient records between 2002 and 2013. Read More

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

Department of Research and Development, Tachikawa Medical Center, Nagaoka, Japan. Electronic address:

Electrocardiogram records were surveyed for the presence of an atrial premature beat (APB) and J waves in patients with coronary heart disease and patients with noncardiac diseases. The prevalence and response of J waves to sudden shortening of the RR interval on the conducted APB were determined and compared between the 2 patients groups. The change in the QRS complexes on the APB was also determined. Read More

Kardiologiia 2019 Jan 27;59(1):28-35. Epub 2019 Jan 27.

Research Institute for Complex Issues of Cardiovascular Disease.

Purpose: to assess diagnostic capabilities of single-photon emission computed tomography (SPECT) in the detection of obstructive coronary artery (CA) lesions, depending on the meeting appropriate use criteria.

Materials And Methods: We used in this retrospective analysis data from 107 patients with previously diagnosed ischemic heart disease (IHD) or in need to exclude it, who were hospitalized in inpatient departments of the Research Institute for Complex Issues of Cardiovascular Diseases in the period from 2012 to 2015. All patients underwent coronary angiography (CAG) and SPECT (the time interval between the studies did not exceed 3 months) for detection of hemodynamically significant CA stenoses. Read More

Syst Rev 2019 Feb 1;8(1):39. Epub 2019 Feb 1.

Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark.

Background: Coronary artery disease and heart failure are both highly prevalent diseases with a global prevalence of 93 million and 40 million. These patients are at increased risk of morbidity and mortality. The management of these patients involves medical therapy, and both diseases can be treated using the heart rate-lowering drug ivabradine. Read More

Ter Arkh 2018 Apr;90(4):42-49

Research Institute for Complex Issues of Cardiovascular Disease, Kemerovo, Russia.

Aim: To study the factors associated with high levels of comorbidity in men and women with coronary artery disease (CAD).

Materials And Methods: The data analyzed 742 patients who were screened in the clinic of the research Institute CPSS in 2011, before planned operation coronary artery bypass grafting. All patients were divided into 2 groups: group I - men (n=595; 58 [54; 64] years), group II - women (n=147; 63 [57; 69] years). Read More

Ter Arkh 2018 Sep;90(9):48-52

Department of clinical and laboratory diagnostics, faculty of advanced physicians, Tyumen State Medical University, Tyumen, Russia.

Aim: The aim of the study is to assess frequency, risk factors and in-hospital outcomes of acute kidney injury after coronary artery bypass grafting in patients with stable angina.

Materials And Methods: The study included patients with stable angina pectoris and indications for coronary artery bypass grafting. We examined 93 patients aged 58±7. Read More

Lakartidningen 2019 Jan 28;116. Epub 2019 Jan 28.

Linkopings universitet Institutionen for medicin och halsa - Linkoping, Sweden Inst för Medicinska vetenskaper, Linköping - Bromma, Sweden.

The ODYSSEY outcome study, including subjects with recent acute coronary syndrome on high dose statin therapy, investigated the effect of 75-150 mg alirocumab given subcutaneously every 2 weeks for 2,8 years in comparison with participants on alirocumab placebo Alirocumab decreased the risk of the primary endpoint coronary death, acute myocardial infarction, hospital admittance because of angina pectoris and ischaemic stroke by 15 percent, decreased the risk of total death by 15 percent and was safe and tolerable during the length of the study. Read More

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):21-26

Former Professor of Neurology and Head - Institute of Neurology, Madras Medical College, Chennai, Emeritus Professor - The Tamil Nadu Dr. M.G.R. Medical University, Adjunct Professor - Indian Institute of Technology (IIT - Chennai), Tamil Nadu, India.

Propranolol is a beta-adrenergic receptor antagonist that was developed by the British scientist Sir James Black primarily for the treatment of angina pectoris, more than 50 years ago. It was not long before several other cardiovascular as well as noncardiovascular therapeutic uses of propranolol were discovered. Propranolol soon became a powerful tool for physicians in the treatment of numerous conditions such as hypertension, cardiac arrhythmias, myocardial infarction, migraine, portal hypertension, anxiety, essential tremors, hyperthyroidism, and pheochromocytoma. Read More

Neth Heart J 2019 Jan 28. Epub 2019 Jan 28.

Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

Vasospastic angina (VSA) is considered a broad diagnostic category including documented spontaneous episodes of angina pectoris produced by coronary epicardial vasospasm as well as those induced during provocative coronary vasospasm testing and coronary microvascular dysfunction due to microvascular spasm. The hallmark feature of VSA is rest angina, which promptly responds to short-acting nitrates; however, VSA can present with a great variety of symptoms, ranging from stable angina to acute coronary syndrome and even ventricular arrhythmia. VSA is more prevalent in females, who can present with symptoms different from those among male patients. Read More

Int J Cardiol 2019 Apr 19;280:1-7. Epub 2019 Jan 19.

Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan. Electronic address:

Background: Angina pectoris (AP) is one of common symptoms of heart disease. The prevalence of AP varies by genders, age and ethnics. This study aimed to estimate the AP prevalence in adults and its change between surveys. Read More

Coron Artery Dis 2019 Jan 22. Epub 2019 Jan 22.

Department of Cardiology, Royal Liverpool University Hospital, Liverpool, UK.

Background: An optimal investigation strategy for patients with suspected angina pectoris (AP) remains elusive. Present guidelines use the Duke Clinical Score (DCS) or the Diamond-Forrester (DF) model to compute the likelihood of coronary artery disease (CAD). This prospective study of patients referred to a chest pain clinic compares the relative values of these two historical models and of pain characteristics only to predict the presence of CAD. Read More

Zhonghua Xin Xue Guan Bing Za Zhi 2019 Jan;47(1):26-33

Tianjin Cardiovascular Institute, Tianjin 300222, China.

To investigate the features of plaques of saphenous venous graft (SVG) with virtual histology intravascular ultrasound (VH-IVUS) in patients underwent coronary artery bypass graft surgery. From March 2016 to March 2018, a total of 45 patients ((64.4±7. Read More

Eur J Public Health 2019 Jan 18. Epub 2019 Jan 18.

Department of Public Health, Amsterdam Public Health (APH) Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Previous research indicates that quality of life impairment as a result of chronic diseases differs between socioeconomic groups, but the pattern seems to vary between health-related quality of life (HRQOL) outcomes. We tested for a one-item and a multi-item outcome whether associations between diseases and HRQOL varied between educational levels.

Methods: Data come from Dutch participants of HELIUS (N =4615, aged 18-70). Read More

Am J Cardiol 2019 Jan 9. Epub 2019 Jan 9.

Mount Auburn Hospital, Cambridge, Massachusetts; Harvard Medical School, Boston, Massachusetts.

J Clin Pharm Ther 2019 Jan 18. Epub 2019 Jan 18.

Drug Safety and Risk Management, Lupin Limited, Mumbai, India.

What Is Known And Objective: The approved indication for trimetazidine (TMZ) was restricted to "add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled by or intolerant to first-line antianginal therapies" in 2012 by the Committee for Medicinal Products for Human Use (CHMP). TMZ was no longer indicated for ophthalmology and otolaryngology (ENT) indications. This drug utilization study analysed actual utilization of TMZ before and after the restriction on its indications to evaluate the effectiveness of risk minimization measures (RMM). Read More

Life Sci 2019 Feb 16;219:329-335. Epub 2019 Jan 16.

Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address:

Objective: The aim of this study was to evaluate the association between serum soluble semaphorin4D (sSema4D) and coronary heart disease (CHD) and the extent of coronary artery stenosis.

Methods: The study included 188 cases that underwent coronary angiography because of precordial pain. One hundred and twenty-eight cases were diagnosed with CHD; 60 cases with negative coronary angiography served as controls. Read More

Medicine (Baltimore) 2019 Jan;98(3):e14165

The Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Aims: Nicorandil, which is a mitochondrial ATP-sensitive potassium channel opener, is believed to improve perioperative myocardial injury (PMI) in patients undergoing percutaneous coronary intervention (PCI), but recent studies have shown that nicorandil treatment did not improve functional and clinical outcomes in patients with angina pectoris who underwent elective PCI. We performed a meta-analysis to investigate the protective effect of nicorandil on perioperative injury in patients with angina pectoris who underwent elective PCI.

Methods: The Medline, EMBASE, and Cochrane databases were searched for randomized clinical trials examining the effects of nicorandil. Read More

Braz J Cardiovasc Surg 2018 Nov-Dec;33(6):626-630

Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

The lateral costal artery has sometimes been identified as the culprit for the "steal phenomenon" after coronary artery bypass grafting, besides being occasionally used for myocardial revascularization. Its branches make anastomoses with the internal thoracic artery through lateral intercostal arteries. We aim to report, on three cases, the clinical significance of a well-developed lateral costal artery after coronary artery bypass grafting. Read More

Eur J Cardiothorac Surg 2019 Jan 10. Epub 2019 Jan 10.

Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: Hospitalizations are a major burden for both patients and society and are potentially preventable. However, data on the burden and causes for hospitalizations after coronary artery bypass grafting (CABG) are sparse. We examined hospitalizations within 1 year after CABG and associated factors. Read More

Kardiochir Torakochirurgia Pol 2018 Dec 31;15(4):238-240. Epub 2018 Dec 31.

Department of Family Medicine, Lviv National Medical University named after Danylo Halytsky, Lviv, Ukraine.

Introduction: Estimation of cardiosurgical intervention risk according to EuroSCORE is an important aspect of cardiosurgery. EuroSCORE allows prediction of the probability of a post-operational fatal outcome.

Aim: To estimate the influence of gallbladder condition on the prognosis after coronary artery bypass grafting (CABG) and and the interactions between metabolic background and cardiosurgical intervention risk. Read More

Health Qual Life Outcomes 2019 Jan 14;17(1):10. Epub 2019 Jan 14.

Department of Health Education & Promotion, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Cardiovascular diseases (CVD) as a most frequent and costly NCDs account for about 17.3 million annual deaths worldwide. About 80% of these deaths are taking place in low and middle income countries (LMIC). Read More

Aten Primaria 2019 Jan 9. Epub 2019 Jan 9.

Unidad de Investigación Área de Salud Don Benito-Villanueva de la Serena. FUNDESALUD, Villanueva de la Serena, Badajoz, España.

Objective: To determine the population attributable fraction (PAF) of the major risk factors (RF) for the occurrence of cardiovascular disease in an Extremadura population cohort and therefore recommend priority preventive measures in health.

Methods: Design, Cohort study.

Location: Representative population sample of a health area of Extremadura (Spain) PARTICIPANTS: 2833 individuals, from 25 to 79 years old, randomly selected and recruited between 2007 and 2009. Read More

Med Sci Monit 2019 Jan 14;25:402-408. Epub 2019 Jan 14.

Department of Comprehensive Internal Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China (mainland).

BACKGROUND The aim of this study was to investigate the effects of puerarin on vascular endothelial function and inflammatory factors in coronary artery disease (CAD) patients with stable angina pectoris (SAP). MATERIAL AND METHODS To evaluate the effects of angina pectoris, the differences of scores of the Seattle angina questionnaire (SAQ), vascular endothelial function [endothelial progenitor cells (EPCs), nitric oxide (NO) and endothelin 1 (ET-1)], and inflammatory factors [tumor necrosis factor a (TNF-α), hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6)] in 2 groups were assessed before and after treatment. RESULTS Regarding the curative effect of angina pectoris, the total effective rate of the treatment group was significantly superior to that of the control group (89% vs. Read More

PeerJ 2019 4;7:e5652. Epub 2019 Jan 4.

Department of the Fifth Affiliated Hospital, Zhengzhou University, Zhengzhou, China.

Background: This study evaluated changes in interleukin (IL)-27 levels in patients with acute coronary syndrome (ACS) and their influence on Th1, Th2, and Th17 cells.

Methods: Serum levels of IL-27, IL-4, IL-17, and interferon (IFN)-γ in healthy subjects as well as patients with ACS, including stable angina pectoris (SA), unstable angina pectoris (UA), and acute myocardial infarction (AMI), were determined using an enzyme-linked immunosorbent assay. The proportions of Th1, Th2, and Th17 cells among peripheral blood mononuclear cells (PBMCs), were measured using flow cytometry, after incubation with phorbol myristate acetate (PMA) for 4 h. Read More

Chin Med J (Engl) 2019 Jan;132(1):96-99

Departments of Cardiovascular Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China.

Herz 2019 Feb;44(1):10-15

, Hildesheim, Deutschland.

The timing of an invasive diagnosis and treatment strategy in patients with an acute coronary syndrome without ST-elevation (NSTE-ACS) depends on the patient's risk profile. In addition to the clinical symptoms, ST/T alterations in the resting ECG as well as an increase and kinetics of troponin are of crucial importance in this setting. For the majority of patients the highly sensitive troponin enables a rapid rule in or rule out strategy of a non-ST-segment elevation myocardial infarction (NSTEMI) with a 0/3 h algorithm. Read More

Front Cardiovasc Med 2018 22;5:170. Epub 2018 Nov 22.

Department of Rheumatology, University of Schleswig-Holstein, Lübeck, Germany.

Anti-beta-1-adrenergic receptor antibodies (anti-βAR Ab) are associated with ischemic cardiomyopathies (ICM). Evidence continues to emerge supporting an autoimmune component to various cardiac diseases. This study compares anti-βAR Ab concentrations in patients with different entities of acute coronary syndromes (ACS) to asymptomatic non-ACS patients with positron-emission computed tomography (PET/CT)-proven atherosclerosis, and healthy controls. Read More

J Pharm Biomed Anal 2019 Mar 29;166:52-65. Epub 2018 Dec 29.

Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Danqi Tongmai tablet (DQTT), an innovative TCM formula under clinical trials, is composed of salvianolic acids (SA) and panax notoginsenosides (PNE) for the treatment of coronary heart disease and angina pectoris. However, the in vivo herb-herb interaction of DQTT remains unclear. In the present research, a rapid, reliable and sensitive method for quantitative analysis of multi-notoginsenoside in rat plasma based on ultra high performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-TQ/MS) was established and then applied to explore the herb-herb interaction mechanism of DQTT based on the pharmacokinetics in acute myocardial ischemia (AMI) and sham rats after oral administration of DQTT and PNE. Read More

Indian Heart J 2018 Dec 5;70 Suppl 3:S245-S249. Epub 2018 Jan 5.

Department of Interventional Cardiology, Hospital El Cruce, Av. Calchaqui 5401, Florencio Varela, CP 1888, Buenos Aires, Argentina.

Background: Coronary fractional flow reserve (FFR) determination is a valuable tool for the assessment of stenosis significance in intermediate coronary obstructions. Maximal hyperemia is mandatory for this determination. Although intravenous (IV) Adenosine is the standard agent used, its use carries an elevated incidence of side effects. Read More

Medicine (Baltimore) 2018 Dec;97(52):e13965

The Second Clinical Medical College, Guangzhou University of Chinese Medicine.

Background: Unstable angina (UA) is a clinically common coronary heart disease. Zhishi xiebai guizhi decoction (ZXGD) has been widely used in the management of UA, although its effective evidence is not clear and there is no systematic review regarding its efficacy and safety. Therefore, we conduct this systematic review protocol to evaluate the efficacy and safety of ZXGD in the treatment of UA. Read More

J Med Case Rep 2018 Dec 27;12(1):390. Epub 2018 Dec 27.

Division of Cardiology, Department of Internal Medicine II, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka City, Tokyo, 181-0004, Japan.

Background: Contrast-induced acute kidney injury is one of the common adverse events related to percutaneous coronary intervention and a predictor for worse outcome. In the setting of percutaneous coronary intervention for chronic total occlusion, large amounts of contrast medium, more than 200-400 mL, are generally injected. A higher dose of contrast medium causes contrast-induced acute kidney injury more frequently. Read More

Probl Radiac Med Radiobiol 2018 Dec;23:246-253

State institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Melnykova str., Kyiv, 04050, Ukraine.

Objective: The study was focused on evaluation of peculiarities of the clinical manifestations of type II diabetesmellitus (TIIDM) in the Chornobyl nuclear power plant (ChNPP) accident clean-up workers (ACUW).

Materials And Methods: The ChNPP ACUW of 1986-1987 period (n = 449, males) and 158 males not exposed to ion-izing radiation (the control group, CG) were involved in the study in 2013-2018. Diagnosis of cardiovascular disease(CVD) and type II diabetes mellitus (TIIDM) was established in accordance with diagnostic standards adopted inUkraine. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13613

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Rationale: Antiphospholipid syndrome (APS) combined with acute coronary syndrome (ACS) is rarely reported.

Patient Concerns: One male patient with APS was admitted to our hospital, who had recent unstable angina (UA).

Diagnosis: The preliminary diagnosis of ACS and UA (BraunwaldiB) was then made. Read More

Ned Tijdschr Geneeskd 2018 Dec 5;162. Epub 2018 Dec 5.

Universiteit Utrecht, UMC Utrecht, divisie Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, afd. Huisartsgeneeskunde.

In patients presenting with acute chest pain, acute myocardial infarction should first be ruled out as a cause as these patients will often need coronary revascularisation. In the remaining patients, those with normal high-sensitivity cardiac troponin levels should undergo additional cardiac investigations to discriminate patients with an episode of unstable angina pectoris from those who have a non-cardiac cause of the chest pain. In the large majority (86%), the medical history does not raise suspicion of angina pectoris and an exercise test will show normal results; in these patients, further cardiac imaging does not seem to be indicated. Read More

Expert Rev Cardiovasc Ther 2019 Feb 29;17(2):127-133. Epub 2018 Dec 29.

b Department of Cardiovascular Medicine , Juntendo University Graduate School of Medicine , Tokyo , Japan.

Introduction: Women have been at a higher risk for adverse cardiac events following percutaneous coronary intervention (PCI), compared with men. Areas covered: In this review, authors discuss the gender differences that can affect the clinical outcomes after PCI and the important points that can be improved on. Expert commentary: Various factors, such as old age and higher prevalence of comorbidities, have been considered to account for the worse clinical outcomes of PCI in women than in men. Read More

Am J Cardiovasc Drugs 2018 Dec 18. Epub 2018 Dec 18.

Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.

Introduction: This post hoc subanalysis of the randomized Japanese Primary Prevention Project investigated whether once-daily low-dose aspirin versus no aspirin reduced the risk of cardiovascular events (CVEs) in patients aged ≥ 70 years with atherosclerotic risk factors.

Methods: Patients aged < 70 years (young-old) or ≥ 70 years (old) with hypertension, dyslipidemia, or diabetes participated between 2005 and 2007. Patients were randomized 1:1 to receive 100 mg enteric-coated aspirin once daily or no aspirin plus standard of care. Read More

Biomed Pharmacother 2019 Jan 5;109:690-700. Epub 2018 Nov 5.

Pharmacology & Toxicology Research Centre, The State Key Laboratory of Core Technology in Innovative Chinese Medicine, Tasly Academy, Tasly Holding Group Co., Ltd, Tianjin 300410, China; School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Chronic stable angina (CSA) presents as a complication of coronary heart disease, leading to a high incidence and mortality rate worldwide. Dantonic or Compound Danshen Dripping Pills (CDDP) is a well-known traditional Chinese medicine used for the treatment of myocardial ischemic diseases, such as angina pectoris (AP), myocardial infarction, and sudden death. Dantonic has been extensively utilized in clinical practice in China for more than 14 years and has proved to be an effective therapy for the treatment of many myocardial ischemic diseases since its approval by CFDA in 1994. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13481

Department of General Surgery, Nanjing Lishui District People's Hospital, Nanjing, Jiangsu, China.

Background: Dazhu Hongjingtian (DZHJT), also named Herba Rhodiolae, has been frequently introduced for patients with angina pectoris in China. However, the add-on effect of DZHJT in unstable angina pectoris (UAP) has not been systematically evaluated. The purpose of this protocol is to provide the methods used to assess the efficacy and safety of DZHJT as adjuvant therapy for management of UAP. Read More

J Diabetes Complications 2019 Feb 23;33(2):134-139. Epub 2018 Nov 23.

Yenisehir Hospital Division of Cardiology, Mersin, Turkey. Electronic address:

Background: It has been shown that functional status of dendritic cells (DCs) in diabetic patients with unstable angina pectoris (UAP) are more mature and activated than diabetic patients without coronary artery disease (CAD) and none diabetic patients with UAP. Accordingly we aimed to assess the activation of DCs in patients with CAD with/and without Diabetes Mellitus (DM) and compare to those in subjects with normal coronary arteries (NCA).

Materials And Methods: Twenty three patients with severe CAD who were scheduled to coronary artery by-pass grafting surgery and 6 patients with angiographycally NCAs were included in the study. Read More

J Am Coll Cardiol 2018 Dec;72(23 Pt A):2856-2858

Department of Cardiovascular, Respiratory, Nephrological, Anaesthetic and Geriatric Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.