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    The Clinical Efficacy of Yindanxinnaotong Soft Capsule in the Treatment of Stroke and Angina Pectoris: A Meta-Analysis.
    Evid Based Complement Alternat Med 2017 30;2017:2060549. Epub 2017 Apr 30.
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
    Objective. To systematically evaluate the clinical efficacy of Yindanxinnaotong (YD) soft capsule in adult patients with cardiovascular diseases (stroke and angina pectoris). Methods. Read More

    Biomarkers of unstable angina pectoris and yangxin decoction intervention: An exploratory metabonomics study of blood plasma.
    Medicine (Baltimore) 2017 May;96(21):e6998
    Second Department of Cardiovascular, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
    Background: This study aimed to explore the related metabolic biomarkers and to observe the effects of Yangxin Decoction (YXD) on plasma metabolism of patients with unstable angina (UA).

    Methods: In total, 10 patients with UA (intervention group) and 10 healthy participants (control group) were recruited for this study from January 2009 to December 2010. Plasma samples from both groups were analyzed using liquid chromatography mass spectrometry (LC-MS). Read More

    [THE CORONARY SINUS REDUCER: A DEVICEBASED THERAPY FOR REFRACTORY ANGINA].
    Harefuah 2016 Nov;155(11):677-681
    Tel Aviv Medical Center, and Sackler Faculty of Medicine, Tel Aviv University.
    Introduction: Alongside the remarkable progress in therapeutic strategies destined to patients with coronary artery disease (CAD), a growing number of patients who suffer from severe and diffuse CAD not amenable for revascularization, continue to experience severe debilitating angina despite optimal medical therapy. The Coronary Sinus (CS) Reducer has emerged as a novel therapeutic strategy for patients with refractory angina pectoris. The Reducer is a stainless steel, balloon-expandable, hourglass shaped device implanted percutaneously through the right internal jugular vein in the coronary sinus. Read More

    Risk classification of highly sensitive troponin I predict presence of vulnerable plaque assessed by dual source coronary computed tomography angiography.
    Int J Cardiovasc Imaging 2017 May 20. Epub 2017 May 20.
    Department of Radiology, The First Affiliated Hospital of China Medical University, 155 Nanjing Bei St, Heping District, Shenyang, China.
    Patients presenting to the emergency department with acute chest pain, negative conventional troponin and electrocardiogram require serial testing to rule out acute coronary syndrome (ACS). We studied the association of highly sensitive troponin (hsTn) I with vulnerable plaque features as detected by coronary dual source computed tomography angiography (DSCTA) and determined whether hsTn I at the time of presentation combined with early DSCTA could improve classification of patients as high-risk or low risk for ACS. We included 220 patients with acute chest pain, negative electrocardiogram and conventional troponin who underwent DSCTA and had hsTn I measured at the time of presentation. Read More

    Long-Term Prognosis of Patients With Intramural Course of Coronary Arteries Assessed With CT Angiography.
    JACC Cardiovasc Imaging 2017 May 11. Epub 2017 May 11.
    Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:
    Objectives: The aim of the present study was to evaluate, in low-to-intermediate pre-test probability patients who were referred for coronary computed tomography angiography (CTA) and did not show obstructive coronary artery disease (CAD), whether an intramural course of a coronary artery is associated with worse outcome compared with patients without an intramural course of the coronary arteries.

    Background: The prognostic value of an intramural course of the coronary arteries on coronary CTA in patients without obstructive CAD is not well-known.

    Methods: The study population consisted of 947 patients with a low-to-intermediate pre-test probability who were referred for coronary CTA and who did not have obstructive CAD. Read More

    Prognostic Value of Coronary CT Angiography With Selective PET Perfusion Imaging in Coronary Artery Disease.
    JACC Cardiovasc Imaging 2017 May 15. Epub 2017 May 15.
    Turku PET Centre, University of Turku, Turku, Finland; Department of Clinical Physiology, Nuclear Medicine and PET, Turku University Hospital, Turku, Finland. Electronic address:
    Objectives: The purpose of this study was to evaluate the prognostic value of sequential hybrid imaging strategy in which positron emission tomography (PET) perfusion imaging is performed selectively in patients with suspected obstructive coronary artery disease (CAD) on coronary computed tomography angiography (CTA).

    Background: Coronary CTA is an accurate diagnostic test for excluding obstructive CAD. However, the positive predictive value is suboptimal. Read More

    Diving and long-term cardiovascular health.
    Occup Med (Lond) 2017 May 19. Epub 2017 May 19.
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, NTNU, 7491 Trondheim, Norway.
    Background: Short-term cardiovascular effects from ambient pressure exposure are known. However, long-term cardiovascular effects from diving in humans have been less studied.

    Aims: To examine possible long-term cardiovascular health effects from occupational diving. Read More

    Cardiovascular risk factors in Chiari malformation and idiopathic intracranial hypertension.
    Brain Behav 2017 May 28;7(5):e00677. Epub 2017 Mar 28.
    Department of NeurosurgeryOslo University Hospital-RikshospitaletOsloNorway.
    Objectives: Both Chiari malformation type 1 (CMI, i.e., the idiopathic caudal ectopy of cerebellar tonsils into foramen magnum) and idiopathic intracranial hypertension (IIH) are characterized by reduced intracranial compliance (ICC) due to disturbed circulation of cerebrospinal fluid (CSF). Read More

    Anomalous Origin of Right Coronary Artery From Left Coronary Sinus-13 Cases Treated With the Reimplantation Technique.
    World J Pediatr Congenit Heart Surg 2017 May;8(3):315-320
    1 Division of Cardiac Surgery, Cruces University Hospital, Barakaldo, Spain.
    Objectives: Anomalous aortic origin of a coronary artery is uncommon but potentially clinically significant. Manifestations vary from asymptomatic patients to those who present with angina pectoris, myocardial infarction, heart failure, syncope, arrhythmias, and sudden death. We describe our experience with surgical reimplantation and results at midterm follow-up. Read More

    [Structural features of the lipid bilayer of the red blood cell membrane in people with isolated hypercholesterolemia without coronary artery disease and in patients with coronary artery disease].
    Ter Arkh 2017 ;89(4):39-44
    Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
    Aim: To identify the specific features of modifying the lipid composition of the red blood cell membrane in people with isolated hypercholesterolemia without coronary heart disease (CHD) and in CHD patients with different functional classes of angina pectoris.

    Subjects And Methods: 92 men with Functional Class II-IV stable angina, 22 men with isolated hypercholesterolemia (HC) without CHD, and 18 healthy men with normal cholesterol levels were examined. Blood plasma cholesterol levels were determined in all the examinees. Read More

    [Impact of shock-wave therapy on the clinical and functional status of patients with coronary heart disease].
    Ter Arkh 2017 ;89(4):22-28
    A.N. Bakulev Research Center for Cardiovascular Surgery, Russian Academy of Sciences, Moscow, Russia.
    Aim: To study of the impact of shock-wave therapy (SWT) on the functional status of patients with coronary heart disease (CHD).

    Subjects And Methods: Thirty-four CHD patients (including 33 men) with left ventricular (LV) asynergic segments, as evidenced by echocardiography (EchoCG), were examined. Their mean age was 60. Read More

    Prognosis of spontaneous coronary artery dissection treated by percutaneous coronary intervention with optical coherence tomography.
    J Cardiol 2017 May 11. Epub 2017 May 11.
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
    Background: Although about half of patients with spontaneous coronary artery dissection (SCAD) face ongoing necrosis, conservative therapy is recommended due to a high complication rate in angiography-guided percutaneous coronary intervention (PCI). The aim of this study was to investigate clinical outcomes of SCAD treated by optical coherence tomography (OCT)-guided PCI.

    Methods: This study consisted of consecutive 306 patients with acute coronary syndrome (ACS) who underwent OCT-guided PCI. Read More

    Differential proteome profile in ischemic heart disease: Prognostic value in chronic angina versus myocardial infarction. A proof of concept.
    Clin Chim Acta 2017 May 10;471:68-75. Epub 2017 May 10.
    Institute of Life Sciences, Scuola Superiore Sant'Anna, P.zza Martiri della Libertà 33, 56127 Pisa, Italy; Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Via Moruzzi 1, 56124 Pisa, Italy. Electronic address:
    The initial clinical manifestation of ischemic heart disease (IHD) i.e. unheralded myocardial infarction (MI) versus chronic angina pectoris (AP) is statistically associated with adverse or mild disease progression respectively in the long-term follow-up. Read More

    Feasibility of a cardiovascular cohort in a Sub-Saharan Africa community: preliminary report of the pilot project TAHES (Tanvè Health Study) in Benin.
    Glob Health Action 2017 ;10(1):1270528
    a U1094, Tropical Neuroepidemiology , INSERM , Limoges , France.
    Background: Faced with the growing burden of cardiovascular disease (CVD) including atherosclerotic in Sub-Saharan Africa (SSA), the development of appropriate prediction tools, based on large cohorts, appears useful for prevention.

    Objective: The objective of the pilot project TAHES (Tanvè Health Study) was to explore the feasibility of a large cohort study focused on CVD and risk factors in Benin.

    Methods: We implemented a prospective cohort over 2 years. Read More

    Mobitz Type 2 AV Block Dissolved With Contrast Injection.
    J Atr Fibrillation 2016 Oct-Nov;9(3):1469. Epub 2016 Oct 31.
    Istanbul University Institute of Cardiology, Department of Cardiology.
    There are many cases in the literature concerning the occurence of atrioventricular block in acute myocardial infarction. The prevelance and management of AV block in the setting of chronic myocardial ischemia remains unclear. Our case presented with stable angina pectoris. Read More

    Conflicts at work are associated with a higher risk of cardiovascular disease.
    Ger Med Sci 2017 26;15:Doc08. Epub 2017 Apr 26.
    Epidemiology, IMS Health, Frankfurt, Germany.
    Background: Only few authors have analyzed the impact of workplace conflicts and the resulting stress on the risk of developing cardiovascular disorders. The goal of this study was to analyze the association between workplace conflicts and cardiovascular disorders in patients treated by German general practitioners. Methods: Patients with an initial documentation of a workplace conflict experience between 2005 and 2014 were identified in 699 general practitioner practices (index date). Read More

    Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE(-/-) Mice Fed with a High-Fat Diet.
    Evid Based Complement Alternat Med 2017 12;2017:3121989. Epub 2017 Apr 12.
    Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China.
    Lipid metabolism dysregulation plays a crucial role in the occurrence of atherosclerosis (As). SCAP/SREBP signaling is the main pathway for regulating lipid metabolism. Tetramethylpyrazine (TMP), a Traditional Chinese Medicine (TCM) for treating angina pectoris, has antiatherosclerotic effects and ameliorates blood lipids disturbance. Read More

    Impact of free thyroxine levels and other clinical factors on bare metal stent restenosis.
    Arch Endocrinol Metab 2017 Mar-Apr;61(2):130-136. Epub 2016 Aug 25.
    Türkiye Yüksek Ihtisas Training and Research Hospital, Cardiology Clinic, Ankara, Turkey.
    Objective: Thyroid hormones have both direct and indirect effects on thermogenesis such as modulating vascular smooth muscle cell proliferation. However, the influence of more subtle changes in thyroid hormones on coronary atherosclerosis remains a matter of speculation. Smooth muscle cells play a crucial role in the pathogenesis of in-stent restenosis (ISR). Read More

    Pseudoxanthoma elasticum.
    Orphanet J Rare Dis 2017 May 10;12(1):85. Epub 2017 May 10.
    Division of Medical Genetics, University of Versailles - Saint Quentin en Yvelines, Paris-Saclay University, 2 avenue de la source de la Bièvre, F-78180, Montigny, France.
    Pseudoxanthoma elasticum (PXE) is a genetic metabolic disease with autosomal recessive inheritance caused by mutations in the ABCC6 gene. The lack of functional ABCC6 protein leads to ectopic mineralization that is most apparent in the elastic tissues of the skin, eyes and blood vessels. The clinical prevalence of PXE has been estimated at between 1 per 100,000 and 1 per 25,000, with slight female predominance. Read More

    Endothelial function predicts 1-year adverse clinical outcome in patients hospitalized in the emergency department chest pain unit.
    Int J Cardiol 2017 May 1. Epub 2017 May 1.
    Division of Cardiovascular Diseases, Mayo Clinic and College of Medicine, Rochester, USA.
    Background: Endothelial function is a marker for cardiovascular risk. Thus, abnormal endothelial function may be associated with adverse 1-year outcome in patients presenting to the emergency department chest pain unit (CPU).

    Methods: Following endothelial function testing, using EndoPAT 2000 in 300 consecutive subjects with chest pain and no history of coronary artery disease (CAD) presenting to CPU, patients underwent coronary computerized tomographic angiography (CCTA) or single-photon emission computed tomography according to availability. Read More

    Association of Diabetic Macular Edema and Proliferative Diabetic Retinopathy With Cardiovascular Disease: A Systematic Review and Meta-analysis.
    JAMA Ophthalmol 2017 May 4. Epub 2017 May 4.
    Singapore Eye Research Institute, Singapore National Eye Centre, National University of Singapore, Singapore3Duke-NUS Medical School, National University of Singapore, Singapore.
    Importance: Previous studies on the relationship between diabetic retinopathy (DR) and cardiovascular disease (CVD) focused on the early stages of DR. Understanding whether patients with type 2 diabetes and severe stages of DR (diabetic macular edema [DME] and proliferative diabetic retinopathy [PDR]) have a higher risk of CVD will allow physicians to more effectively counsel patients.

    Objective: To examine the association of severe stages of DR (DME and PDR) with incident CVD in patients with type 2 diabetes. Read More

    Association between echocardiographic epicardial fat thickness and circulating endothelial progenitor cell level in patients with stable angina pectoris.
    Clin Cardiol 2017 May 2. Epub 2017 May 2.
    Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
    Background: Epicardial adipose tissue is associated with coronary artery disease (CAD). Circulating endothelial progenitor cell (EPC) level represents a marker of endothelial dysfunction and vascular health. However, the relationship between epicardial fat and circulating EPC remains unknown. Read More

    Association between periodontal flap surgery for periodontitis and vasculogenic erectile dysfunction in Koreans.
    J Periodontal Implant Sci 2017 Apr 29;47(2):96-105. Epub 2017 Apr 29.
    Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea.
    Purpose: The National Health Insurance Service-National Sample Cohort and medical checkup data from 2002 to 2013 were used to evaluate the association between periodontal surgery for the treatment of periodontitis (PSTP) and vasculogenic erectile dysfunction (VED).

    Methods: Bivariate and multivariate logistic regression analyses were applied to a longitudinal retrospective database to assess the association between PSTP and VED while adjusting for the potential confounding effects of sociodemographic factors (age, household income, insurance status, health status, residence area, and smoking status) and comorbidities (diabetes mellitus, angina pectoris, cerebral infarction, and myocardial infarction).

    Results: Among the 7,148 PSTP within the 268,296 recruited subjects, the overall prevalence of VED in PSTP was 1. Read More

    Predictive Indices for Functional Improvement and Deterioration, Institutionalization, and Death Among Elderly Medicare Beneficiaries.
    PM R 2017 Apr 26. Epub 2017 Apr 26.
    Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
    Background: Prediction models can help clinicians provide the best and most appropriate care to their patients and can help policy makers design services for groups at highest risk for poor outcomes.

    Objective: To develop prediction models identifying both risk factors and protective factors for functional deterioration, institutionalization, and death.

    Design: Cohort study using data from the Medicare Current Beneficiary Survey (MCBS) SETTING: Community survey. Read More

    Higher coronary artery calcification score is associated with adverse prognosis in patients with stable angina pectoris.
    J Thorac Dis 2017 Mar;9(3):582-589
    Department of Cardiology, Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi 214002, China.
    Background: Coronary artery calcification (CAC) indicates the presence of atherosclerotic lesions and serves as a marker of prognosis in patients with coronary artery disease (CAD). This study evaluated the value of the CAC score for determining the prognosis of patients with stable angina pectoris (SAP).

    Methods: A total of 106 consecutive patients with SAP were enrolled in this study from January 2011 to June 2014; from these patients, 640 multi-slice computer tomography (MSCT) samples were used to obtain CAC scores. Read More

    Computed tomography derived fractional flow reserve testing in stable patients with typical angina pectoris: influence on downstream rate of invasive coronary angiography.
    Eur Heart J Cardiovasc Imaging 2017 Apr 20. Epub 2017 Apr 20.
    Department of Cardiology, Aarhus University Hospital-Skejby, 8200 Aarhus N, Denmark.
    Aims: To assess the use of downstream coronary angiography (ICA) and short-term safety of frontline coronary CT angiography (CTA) with selective CT-derived fractional flow reserve (FFRCT) testing in stable patients with typical angina pectoris.

    Methods And Results: Between 1 January 2016 and 30 June 2016 all patients (N = 774) referred to non-emergent ICA or coronary CTA at Aarhus University Hospital on a suspicion of CAD had frontline CTA performed. Downstream testing and treatment within 3 months and adverse events ≥90 days were registered. Read More

    In vitro Study of the Thrombogenic Activity of Platelet-derived Microparticles from Patients with Acute Coronary Syndrome.
    Ann Clin Lab Sci 2017 Mar;47(2):156-161
    Cardiovascular Department, The Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, China.
    Background: To observe the thrombogenic activity of platelet-derived microparticles (PMPs) in PMP-free plasma from non-coronary artery disease (non-CAD) patients and explore the relationship between PMPs and thrombosis in acute coronary syndrome (ACS) patients.

    Methods: Patients with ACS who were diagnosed at the outpatient department of cardiology in the People's Hospital of Xinjiang Uygur Autonomous Region, and non-CAD subjects were enrolled in the study from January 2011 to December 2014. Subjects were assigned to the ACS group (n=200) (which consisted of patients with acute myocardial infarction (AMI, n=100) and patients with unstable angina pectoris) (UAP, n=100), or to the non-CAD group (n=100). Read More

    High adherence to therapy and low cardiac mortality and morbidity in patients after acute coronary syndrome systematically managed by office-based cardiologists in Germany: 1-year outcomes of the ProAcor Study.
    Vasc Health Risk Manag 2017 6;13:127-137. Epub 2017 Apr 6.
    Kardiologische Gemeinschaftspraxis und Herzkatheterlabor Berlin-Charlottenburg, Berlin, Germany.
    We aimed to assess patient acceptance and effectiveness of a 12-month structured management program in patients after an acute coronary syndrome (ACS) event who were treated in a special setting of office-based cardiologists. The program comprised patient documentation with a specific tool (Bundesverband Niedergelassener Kardiologen [German Federation of Office-Based Cardiologists] cardiac pass with visit scheduling) shared by the hospital physician and the office-based cardiologist, the definition of individual treatment targets, and the systematic information of patients in order to optimize adherence to therapy. Participating centers (36 hospitals, 60 office-based cardiologists) included a total of 1,003 patients with ACS (ST-segment elevation myocardial infarction [STEMI] 44. Read More

    Prinzmetals angina presenting with non critical lesion with normal FFR -to stent or not to stent.
    Int J Cardiol 2017 Jul 4;238:1-4. Epub 2017 Apr 4.
    Fortis Hospital, Cunningham Road, Bangalore, India.
    Variant angina also called Prinzmetals angina is an enigma characterized by transient circadian symptoms of chest pain associated with ECG changes. The patient is symptom free with normal ECG and echo during symptom free periods. We present a case associated with transient ST-segment elevation with non critical lesion with normal FFR. Read More

    Propranolol.
    Profiles Drug Subst Excip Relat Methodol 2017 6;42:287-338. Epub 2017 Apr 6.
    College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
    Propranolol is a noncardioselective β-blocker. It is reported to have membrane-stabilizing properties, but it does not own intrinsic sympathomimetic activity. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. Read More

    Possible increase in insulin resistance and concealed glucose-coupled potassium-lowering mechanisms during acute coronary syndrome documented by covariance structure analysis.
    PLoS One 2017 21;12(4):e0176435. Epub 2017 Apr 21.
    Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JAPAN.
    Objective: Although glucose-insulin-potassium (GIK) therapy ought to be beneficial for ischemic heart disease in general, variable outcomes in many clinical trials of GIK in acute coronary syndrome (ACS) had a controversial impact. This study was designed to examine whether "insulin resistance" is involved in ACS and to clarify other potential intrinsic compensatory mechanisms for GIK tolerance through highly statistical procedure.

    Methods And Results: We compared the degree of insulin resistance during ACS attack and remission phase after treatment in individual patients (n = 104). Read More

    Chronic total coronary occlusion: treatment results.
    Scand Cardiovasc J 2017 Apr 20:1-5. Epub 2017 Apr 20.
    a Department of Cardiology , Aalborg University Hospital , Aalborg , Denmark.
    Objectives: To describe the clinical and procedural coronary chronic total occlusion (CTO) treatment results in a Nordic PCI centre during the implementation of a CTO treatment program.

    Design: In a retrospective registry study, we assessed; (1) indication for the procedure, (2) Canadian Cardiovascular Society angina pectoris score (CCS)/New York Heart Association (NYHA) heart failure score, (3) lesion complexity and (4) adverse events during hospital stay and three months following the index procedure.

    Results: The study cohort included 503 patients (594 lesions). Read More

    Comorbidities of rheumatoid arthritis: Results from the Korean National Health and Nutrition Examination Survey.
    PLoS One 2017 19;12(4):e0176260. Epub 2017 Apr 19.
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    This study aimed to evaluate the prevalence of comorbidities in patients with rheumatoid arthritis (RA) compared with the non-RA population. The 2010-2012 Korea National Health and Nutrition Examination Survey (KNHANES), which assesses the general health status of populations in South Korea using interviews and basic health assessment, was analyzed retrospectively. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed in patients with RA compared with the non-RA population. Read More

    AMP-activated protein kinase mediates the effects of lipoprotein-associated phospholipase A2 on endothelial dysfunction in atherosclerosis.
    Exp Ther Med 2017 Apr 21;13(4):1622-1629. Epub 2017 Feb 21.
    Tianjin Cardiovascular Institute, Tianjin 300222, P.R. China.
    The present study aimed to investigate the effects of lipoprotein-associated phospholipase A2 (Lp-PLA2) on endothelial dysfunction in an in vitro cell model of atherosclerosis, and to determine whether AMP-activated protein kinase (AMPK) mediates the effects of Lp-PLA2 on endothelial dysfunction. A total of 392 patients with coronary artery disease (CAD), including various sub-conditions, were recruited, and the plasma concentrations of Lp-PLA2 were evaluated. In addition, an in vitro model of atherosclerosis was established by exposing human umbilical vein endothelial cells (HUVECs) to oxidized low-density lipoprotein (oxLDL). Read More

    Long-term statin use before primary percutaneous coronary intervention improves treatment outcomes of acute myocardial infarction.
    Exp Ther Med 2017 Apr 22;13(4):1578-1583. Epub 2017 Feb 22.
    Department of Cardiology, Kunming General Hospital of Chengdu Military Command, Kunming, Yunnan 650032, P.R. China.
    Numerous studies have reported that high-dose statin loading therapy prior to primary percutaneous coronary intervention (PPCI) improves the clinical outcomes of patients following acute myocardial infarction (AMI). However, little is known about the effects of long-term statin use prior to PPCI on such outcomes. Therefore, the aim of the present analysis was to clarify the effects of long-term statin use before PPCI on the treatment outcomes of patients following AMI. Read More

    Role of TLR4 and miR-155 in peripheral blood mononuclear cell-mediated inflammatory reaction in coronary slow flow and coronary arteriosclerosis patients.
    J Clin Lab Anal 2017 Apr 13. Epub 2017 Apr 13.
    Department of Cardiology, First Affiliated Hospital, Nanchang University, Nanchang, China.
    Background: To study the role of toll-like receptor 4 (TLR4) and MicroRNA-155 (miR-155) in the peripheral blood mononuclear cell (PBMC)-mediated inflammation in coronary slow flow (CSF) and coronary arteriosclerosis.

    Methods: Patients were divided into acute coronary syndrome (ACS), stable angina pectoris (SAP), CSF, and healthy control (HC) groups. The isolated PBMCs were treated with lipopolysaccharide (LPS)/and antagomiR-155. Read More

    Update on the clinical utility of coronary computed tomographic angiography in stable angina pectoris.
    Minerva Cardioangiol 2017 Jun;65(3):201-213
    Cardiology Department, Concord Hospital, The University of Sydney, Sydney, Australia -
    Over the last decade, coronary computed tomographic angiography (CCTA) has emerged as a valuable non-invasive imaging modality with excellent diagnostic performance compared to invasive coronary angiography (ICA) for identifying patients with coronary artery disease (CAD). Beyond the diagnosis of CAD, CCTA also provides valuable prognostic information. While patients with normal CCTA have excellent long-term prognosis, among those with CAD, increasing CAD extent and severity is associated with increased cardiovascular event risk over both medium- and long-term follow-up in both men and women. Read More

    Cardiac shock-wave therapy in the treatment of coronary artery disease: systematic review and meta-analysis.
    Cardiovasc Ultrasound 2017 Apr 12;15(1):11. Epub 2017 Apr 12.
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America.
    Aim: To systematically review currently available cardiac shock-wave therapy (CSWT) studies in humans and perform meta-analysis regarding anti-anginal efficacy of CSWT.

    Methods: The Cochrane Controlled Trials Register, Medline, Medscape, Research Gate, Science Direct, and Web of Science databases were explored. In total 39 studies evaluating the efficacy of CSWT in patients with stable angina were identified including single arm, non- and randomized trials. Read More

    Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris.
    Heart Vessels 2017 Apr 10. Epub 2017 Apr 10.
    Department of Integrated Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan.
    Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. Read More

    Comparison of Clinical Characteristics and Outcomes of Patients With Versus Without Diabetes Mellitus and With Versus Without Angina Pectoris (from the Duke Databank for Cardiovascular Disease).
    Am J Cardiol 2017 Jun 16;119(11):1703-1709. Epub 2017 Mar 16.
    Division of Cardiology, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina.
    Angina pectoris (AP) has different prognostic implications in various populations. Patients with diabetes mellitus (DM) may experience neuropathy such that AP may not be perceived in the setting of coronary artery disease (CAD). The prognostic utility of AP in DM patients with CAD is not well known. Read More

    Endocan Levels and Coronary Collateral Circulation in Stable Angina Pectoris: A Pilot Study.
    Angiology 2017 Jan 1:3319717703835. Epub 2017 Jan 1.
    1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
    We investigated the relationship between endocan (a marker of systemic inflammation) and the development of coronary collateral circulation (CCC) as evaluated by coronary angiography in patients with chronic stable angina pectoris. A total of 90 patients (32 poor CCC and 58 good CCC) were included in this study. Endocan levels were determined using a commercially available sandwich enzyme-linked immunosorbent assay kit with high sensitivity and specificity for detection of human endocan. Read More

    The inflammatory biomarker YKL-40 decreases stepwise after exercise stress test.
    Cardiovasc Endocrinol 2016 Mar 4;5(1):21-27. Epub 2016 Jan 4.
    Department of Cardiology, Copenhagen University Hospital Rigshospitalet.
    Background: Serum YKL-40 is an inflammatory biomarker associated with disease activity and mortality in diseases characterized by inflammation such as coronary artery disease (CAD). Exercise has a positive effect on CAD, possibly mediated by a decreased inflammatory activity. This study aimed to compare serial measurements of serum YKL-40 before and after exercise in patients with stable CAD versus controls. Read More

    Dynamic Computed Tomography Myocardial Perfusion Imaging: Comparison of Clinical Analysis Methods for the Detection of Vessel-Specific Ischemia.
    Circ Cardiovasc Imaging 2017 Apr;10(4)
    From the Centre for Advanced Cardiovascular Imaging, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom and Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom (A.R., A.W., F. Pirro, F. Pugliese); Siemens Healthineers, Forchheim, Germany (E.K.); Institute of Cardiovascular Science, University College London, United Kingdom (J.C.M.); and Departments of Cardiology and Radiology, Erasmus MC University Medical Centre Rotterdam, The Netherlands (K.N.).
    Background: The clinical analysis of myocardial dynamic computed tomography myocardial perfusion imaging lacks standardization. The objective of this prospective study was to compare different analysis approaches to diagnose ischemia in patients with stable angina referred for invasive coronary angiography.

    Methods And Results: Patients referred for evaluation of stable angina symptoms underwent adenosine-stress dynamic computed tomography myocardial perfusion imaging with a second-generation dual-source scanner. Read More

    Ratios of One-Carbon Metabolites Are Functional Markers of B-Vitamin Status in a Norwegian Coronary Angiography Screening Cohort.
    J Nutr 2017 Apr 5. Epub 2017 Apr 5.
    Department of Clinical Science, University of Bergen, Bergen, Norway.
    Background: Functional (metabolic) markers of B-vitamin status, including plasma total homocysteine (tHcy) for folate and plasma methylmalonic acid (MMA) for vitamin B-12, suffer from moderate sensitivity and poor specificity. Ratios of metabolites belonging to the same pathway may have better performance characteristics.Objective: We evaluated the ratios of tHcy to total cysteine (tCys; Hcy:Cys), tHcy to creatinine (Hcy:Cre), and tHcy to tCys to creatinine (Hcy:Cys:Cre) as functional markers of B-vitamin status represented by a summary score composed of folate, cobalamin, betaine, pyridoxal 5'-phosphate (PLP), and riboflavin concentrations measured in plasma. Read More

    Evaluation on curative effect and safety of interventional treatment for patients with acute myocardial infarction.
    Pak J Pharm Sci 2016 Nov;29(6(Suppl)):2363-2371
    Deparment of Vasculocardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    To evaluate the effectiveness and recent safety of emergency and selective percutaneous coronary intervention (PCI) in elderly patients (>80 years old) with acute myocardial infarction (AMI). 120 elderly patients with coronary heart disease (CHD) were divided into AMI group (with 55 cases) and non-myocardial infarction group (control group with 65 cases). Among the AMI group, there were 18 cases underwent emergency PCI within 12 hours after the onset, (AMI emergency PCI group), the rest 37 cases were AMI selective PCI group. Read More

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