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    Specifics of fetuin-A levels in distinct types of chronic heart failure.
    J Clin Lab Anal 2017 Feb 18. Epub 2017 Feb 18.
    Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, Department of Internal Medicine I, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany.
    Introduction: Fetuin-A has been described to correlate inversely with vascular calcification both in animal models but also in patients with heart and renal disease. In this current study, we sought to investigate whether fetuin-A might be a useful marker for the discrimination of ischemic (ICM) from dilated cardiomyopathy (DCM).

    Methods: A total of 124 non-consecutive patients were included in this study, 59 patients suffered from ICM and 65 patients from DCM. Read More

    Association between bariatric surgery and rate of hospitalisations for stable angina pectoris in obese adults.
    Heart 2017 Feb 16. Epub 2017 Feb 16.
    Department of Emergency Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.
    Objective: Obesity and stable angina pectoris (SAP) are important public health problems in the USA. However, little is known about whether weight reduction affects the rate of SAP-related morbidities. This study was designed to test the hypothesis that bariatric surgery is associated with a lower rate of hospitalisations for SAP in obese adults. Read More

    Arginine methylation dysfunction increased risk of acute coronary syndrome in coronary artery disease population: A case-control study.
    Medicine (Baltimore) 2017 Feb;96(7):e6074
    aDepartment of Internal Medicine bDepartment of Cardiology cClinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    The plasma levels of asymmetric dimethylarginine (ADMA) had been proved to be an independent cardiovascular risk factor. Few studies involved the entire arginine methylation dysfunction. This study was designed to investigate whether arginine methylation dysfunction is associated with acute coronary syndrome risk in coronary artery disease population. Read More

    Symptomatic Type IV Dual Left Anterior Descending Coronary Artery.
    J Investig Med High Impact Case Rep 2016 Oct-Dec;4(4):2324709616683723. Epub 2016 Dec 1.
    University of Nicosia Medical School, Nicosia, Cyprus.
    Dual left anterior descending coronary artery is a rare congenital anomaly with 4 subtypes. Double left anterior descending coronary artery originating from the left main stem and the right coronary artery (type IV dual left anterior descending artery) has been reported to occur in 0.01% to 0. Read More

    Angina and Its Management.
    J Cardiovasc Pharmacol Ther 2016 Jan 1:1074248416679733. Epub 2016 Jan 1.
    3 Saint Louis University School of Medicine, St. Louis, MO, USA.
    Angina pectoris is defined as substernal chest pain, pressure, or discomfort that is typically exacerbated by exertion and/or emotional stress, lasts greater than 30 to 60 seconds, and is relieved by rest and nitroglycerin. There are approximately 10 million people in the United States who have angina, and there are over 500 000 cases diagnosed per year. Several studies now show that angina itself is a predictor of major adverse cardiac events. Read More

    Post-challenge insulin concentration is useful for differentiating between coronary artery disease and cardiac syndrome X in subjects without known diabetes mellitus.
    Diabetol Metab Syndr 2017 8;9:10. Epub 2017 Feb 8.
    0000 0001 0425 5914grid.260770.4School of Medicine, National Yang Ming University, Taipei, Taiwan ; 0000 0004 0573 0731grid.410764.0Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
    Background: Cardiac syndrome X (CSX) is characterized by angina pectoris but with patent coronary arteries. Our previous study demonstrated that subjects with CSX had a higher fasting insulin-resistance (IR) than the controls. However, few studies have investigated the degree of IR, including oral glucose tolerance test (OGTT)-derived indices and profiles of metabolic abnormalities between CSX and coronary artery disease (CAD). Read More

    A Chinese patent medicine Salvia miltiorrhiza depside salts for infusion combined with conventional treatment for patients with angina pectoris: A systematic review and meta-analysis of randomized controlled trials.
    Phytomedicine 2017 Feb 6;25:100-117. Epub 2017 Jan 6.
    Department of Epidemiology, University of California-Los Angeles, California 90095, United States.
    Background: Currently, many trials have been conducted to investigate the beneficial and harmful effects of Salvia miltiorrhiza depside salts for infusion for treating patients with angina pectoris. It is important to systematically and criticallyevaluate the existing literature into providing a pooled effect to examine outcomes of angina pectoris with Salvia miltiorrhiza depside salts for infusion.

    Purpose: A systematic review and meta-analysis were performed to determine the clinical curative effect and safety of Salvia miltiorrhiza depside salts for infusion for angina pectoris and provide clear evidence to inform clinical practice. Read More

    A Rare Case of Angina Pectoris with the Longest Ectopic Left Main Coronary Artery Arising from Right Sinus of Valsalva and a Prepulmonic Course.
    Case Rep Cardiol 2017 15;2017:5483257. Epub 2017 Jan 15.
    Department of Cardiology, LPS Institute of Cardiology, G.S.V.M. Medical College, Kanpur, Uttar Pradesh 208002, India.
    Knowledge of the morphoanatomical characteristics of the main trunk of the left coronary artery as well as its variations is cornerstone of hemodynamic, correct interpretation of coronary angiogram and for revascularization purpose. The left main coronary artery (LMCA) ranges from 3 to 6 mm in diameter and may be up to 10 to 15 mm in length in humans. We here report a case of the longest anomalous LMCA (56 mm) reported so far in a 35-year-old man with chronic stable angina arising from right sinus of valsalva as seen on conventional angiogram and multidetector computerized tomogram (MDCT). Read More

    Ranolazine for stable angina pectoris.
    Cochrane Database Syst Rev 2017 Feb 8;2:CD011747. Epub 2017 Feb 8.
    Department of Nephrology, Universidad Peruana Cayetano Heredia, Hospital Cayetano Heredia, Honorio Delgado 420, Lima, Peru, 31.
    Background: Stable angina pectoris is a chronic medical condition with significant impact on mortality and quality of life; it can be macrovascular or microvascular in origin. Ranolazine is a second-line anti-anginal drug approved for use in people with stable angina. However, the effects of ranolazine for people with angina are considered to be modest, with uncertain clinical relevance. Read More

    Evaluation on curative effect and safety of interventional treatment for patients with acute myocardial infarction.
    Pak J Pharm Sci 2016 Nov;29(6(Suppl)):2363-2371
    Deparment of Vasculocardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    To evaluate the effectiveness and recent safety of emergency and selective percutaneous coronary intervention (PCI) in elderly patients (>80 years old) with acute myocardial infarction (AMI). 120 elderly patients with coronary heart disease (CHD) were divided into AMI group (with 55 cases) and non-myocardial infarction group (control group with 65 cases). Among the AMI group, there were 18 cases underwent emergency PCI within 12 hours after the onset, (AMI emergency PCI group), the rest 37 cases were AMI selective PCI group. Read More

    Expression of Platelet Collagen Receptor Glycoprotein VI in Coronary Heart Disease: Interaction between Platelets and Endothelial Cells.
    Clin Lab 2016 Jul;62(7):1279-1286
    Background: 1) To investigate the expression of platelet collagen receptor glycoprotein VI (GPVI) on the surface of platelets in patients with coronary heart disease (CHD). 2) To investigate the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the surface of endothelial cells after exposure to subjects' platelets.

    Methods: Platelets were extracted from blood samples of 97 subjects including 43 with acute coronary syndrome (ACS), 21 with stable angina pectoris (SAP), and 33 serving as controls in which CHD was excluded. Read More

    Interventional treatment of the left subclavian in 2 patients with coronary steal syndrome.
    World J Cardiol 2017 Jan;9(1):65-70
    Julia Heid, Britta Vogel, Arnt Kristen, Wanda Kloos, Benedikt Kohler, Hugo A Katus, Grigorios Korosoglou, Department of Internal Medicine III, University Hospital Heidelberg, 69120 Heidelberg, Germany.
    In patients with history of coronary artery disease angina pectoris is usually attributed to the progression of atherosclerotic lesions. However, in patients with previous coronary artery bypass graft operation (CABG) using internal mammary artery grafts, great vessel disease should also be considered. Herein we present two patients with history of CABG whose symptoms were suspicious for coronary ischemia. Read More

    Relationship between yellow plaque grade and tissue protrusion after stent implantation: A coronary angioscopy study.
    J Cardiol 2017 Feb 1. Epub 2017 Feb 1.
    Department of Cardiovascular Medicine, Ehime Prefectural Imabari Hospital, Imabari, Japan.
    Background: Tissue protrusion detected with optical coherence tomography after percutaneous coronary intervention using stents is one of the risk factors for early stent thrombosis. However, tissue protrusion features have not been described. The aim of this study was to compare tissue morphology at stented sites with or without tissue protrusion by using coronary angioscopy. Read More

    Serum Acylcarnitines and Risk of Cardiovascular Death and Acute Myocardial Infarction in Patients With Stable Angina Pectoris.
    J Am Heart Assoc 2017 Feb 3;6(2). Epub 2017 Feb 3.
    Department of Clinical Science, University of Bergen, Norway.
    Background: Excess levels of serum acylcarnitines, which are intermediate products in metabolism, have been observed in metabolic diseases such as type 2 diabetes mellitus. However, it is not known whether acylcarnitines may prospectively predict risk of cardiovascular death or acute myocardial infarction in patients with stable angina pectoris.

    Methods And Results: This study included 4164 patients (median age, 62 years; 72% men). Read More

    Dual Supply of Left Anterior Descending Coronary Artery on Coronary Computed Tomographic Angiography Not Recognized on Previous Cardiac Catheterizations.
    Can J Cardiol 2016 Nov 30. Epub 2016 Nov 30.
    Department of Radiology, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address:
    A dual left anterior descending (LAD) artery is an infrequent anomaly of the coronary circulation with rare variations that may cause symptoms. We report a 60-year-old man who underwent multiple percutaneous cardiac catheterizations with stent placements and presented with recurrent angina pectoris. Coronary computed tomographic angiography demonstrated a dual LAD with the long and short LADs originating from the right coronary artery and the left main coronary artery, respectively. Read More

    The application of thromboelastogram in detection of indexes of antiplatelet therapy for coronary heart disease.
    J Thorac Dis 2016 Dec;8(12):3515-3520
    Department of Cardiology, Dagang Hospital of Binhai New Area, Tianjin 300270, China.
    Background: This study aims to explore the application value of thromboelastogram (TEG) in antiplatelet therapy in coronary artery intervention.

    Methods: A retrospective analysis of 90 cases of coronary interventional treatment was conducted in our hospital from January 2010 to January 2012. Cases were divided into three groups, according to the kind of coronary heart disease: angina pectoris (AP) group (30 cases), unstable angina pectoris (UAP) group (30 cases) and acute myocardial infarction (AMI) group (30 cases). Read More

    Frequency of craniofacial pain in patients with ischemic heart disease.
    J Clin Exp Dent 2017 Jan 1;9(1):e91-e95. Epub 2017 Jan 1.
    Associate Professor, Dept. of Oral Medicine, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: Referred craniofacial pain of cardiac origin might be the only symptom of ischemic heart accidents. This study aimed to determine the frequency of craniofacial pain in patients with ischemic heart disease.

    Material And Methods: This cross-sectional study was accomplished on 296 patients who met the criteria of having ischemic heart disease. Read More

    Magnetic resonance imaging findings of isolated abducent nerve palsy induced by vascular compression of vertebrobasilar dolichoectasia.
    J Neurosci Rural Pract 2017 Jan-Mar;8(1):124-127
    Department of Neurosurgery, University of Fukui, Fukui, Japan.
    If the origin of isolated abducent nerve palsy cannot be found on neuroradiological examinations, diabetes mellitus is known as a probable cause; however, some cases show no potential causes of isolated abducent nerve palsy. Here, we report a 74-year-old male who suffered from diplopia due to isolated left abducent nerve palsy. Magnetic resonance angiography and fast imaging employing steady-state acquisition imaging clearly showed a dolichoectasic vertebrobasilar artery compressing the left abducent nerve upward and outward. Read More

    Myocardial Bridge Complicated by Acute Myocardial Infarction.
    Rev Cardiovasc Med 2016 ;17(3-4):149-153
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA; Division of Cardiology, Atlanta Veterans Affairs Medical Center, Decatur, GA.
    Typically, myocardial bridging (MB) is considered a relatively benign condition; however, serious complications such as angina pectoris, myocardial infarction (MI), and sudden cardiac death may occur. The diagnosis and appropriate treatment of this pathology are important. We report a case of acute anterior wall ST-elevation MI occurring as a complication of MB involving the mid segment of the left anterior descending artery in a young, otherwise healthy woman who underwent a primary stenting procedure. Read More

    Hypertrophic obstructive cardiomyopathy with multiple coronary arteries to right ventricular microfistulas: a case report and review of the literature.
    J Med Case Rep 2017 Jan 31;11(1):24. Epub 2017 Jan 31.
    Department of Cardiology, Swai Man Singh Medical College, Jaipur, Rajasthan, India.
    Background: Coronary artery microfistulas are a rare anomaly; their association with hypertrophic cardiomyopathy is even rarer and can lead to serious cardiac complications owing to coronary steal phenomena such as angina pectoris, myocardial infarction, congestive heart failure, ventricular and supraventricular arrhythmias, syncope, and sudden death.

    Case Presentation: A 32-year-old Indian woman presented to our institute with severe angina on exertion and multiple episodes of pre-syncope. Echocardiography revealed hypertrophic obstructive cardiomyopathy. Read More

    Prediction of risk of cardiovascular events in patients with mild to moderate coronary artery lesions using naïve Bayesian networks.
    J Geriatr Cardiol 2016 Nov;13(11):899-905
    Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
    Background: This prospective study integrated multiple clinical indexes and inflammatory markers associated with coronary atherosclerotic vulnerable plaque to establish a risk prediction model that can evaluate a patient with certain risk factors for the likelihood of the occurrence of a coronary heart disease event within one year.

    Methods: This study enrolled in 2686 patients with mild to moderate coronary artery lesions. Eighty-five indexes were recorded, included baseline clinical data, laboratory studies, and procedural characteristics. Read More

    [Atypical complaint in myocardial ischaemia: belching].
    Orv Hetil 2017 Feb;158(5):183-186
    Kardiológia, Budai Irgalmasrendi Kórház Budapest, Árpád fejedelem u. 7., 1023.
    While educating non-medical personnel on acute coronary syndrome we often emphasize the importance of early recognition and urgent transfer to acute cardiac center of patients with acute myocardial infarction. Aside from typical symptoms of chest tightness and pain radiating to shoulder, arm and jaw, angina often presents with atypical, non-cardiac complaints. These symptoms, often suggesting gastrointestinal problems, can sometimes mislead even the most experienced physicians. Read More

    Associations of common chronic non-communicable diseases and medical conditions with sleep-related problems in a population-based health examination study.
    Sleep Sci 2016 Jul-Sep;9(3):249-254. Epub 2016 Nov 25.
    Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
    A cross-sectional population-based survey, the National FINRISK 2012 Study, designed to monitor chronic diseases and their risk factors in Finland. A random sample of 10,000 adults aged 25-74 years, and of them, 64% (n=6424) participated the study. Participants subjectively reported the total durations for sleep and naps (n=6238), sleep quality (n=5878), bedtimes and wake-up times separately for working days and weekends yielding the amount of sleep debt (n=5878), and the seasonal variation in sleep duration (n=4852). Read More

    Drug Therapy for Stable Angina Pectoris.
    Drugs 2017 Mar;77(3):265-284
    The University of Oklahoma Health Sciences Center and The Veteran Affairs Medical Center, 920 Stanton L. Young Blvd., WP 3010, Oklahoma City, OK, 73104, USA.
    Chronic stable angina pectoris refers to the predictable, reproducible occurrence of pressure or a choking sensation in the chest or adjacent areas caused by myocardial ischemia in association with physical or emotional stress, and cessation of exertion and or sublingual nitroglycerin invariably relieves the discomfort. It is a common presenting symptom of severe narrowing of one or more coronary arteries, non-obstructive coronary arteries, or even when the coronary arteries are angiographically normal. Patients often avoid activities which precipitate symptoms and have impaired quality of life. Read More

    A novel side branch protection technique in coronary stent implantation: Jailed Corsair technique.
    Cardiovasc Revasc Med 2017 Jan 17. Epub 2017 Jan 17.
    Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
    Side branch occlusion, which was one of the common complications in percutaneous coronary interventions, was closely associated with cardiac death and myocardial infarction. Clinical guidelines also support the importance of preservation of physiologic blood flow in SB during PCI to bifurcation lesions. In order to avoid side branch occlusion during stent implantation, we often performed the jailed wire technique, in which a conventional guide wire was inserted to the side branch before stent implantation to the main vessel. Read More

    Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12 are significantly correlated with the categories of coronary artery diseases.
    BMC Cardiovasc Disord 2017 Jan 21;17(1):37. Epub 2017 Jan 21.
    East Branch, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, No. 585 Hong He North Road, Longquan District, Chengdu, 610101, China.
    Background: Homocysteine (Hcy) has been considered as an independent risk factor for coronary artery disease (CAD). Folic acid and vitamin B12 are two vital regulators in Hcy metabolic process. We evaluated the correlations between serum Hcy, folic acid and vitamin B12 with the categories of CAD. Read More

    Association between MMP-3 and MMP-9 polymorphisms and coronary artery disease.
    Biomed Rep 2016 Dec 18;5(6):709-714. Epub 2016 Oct 18.
    Cardiovascular Surgery, Heart Center, Cumhuriyet University, Sivas 58140, Turkey.
    Matrix metalloproteinase (MMP)-3 and MMP-9 polymorphisms are characterized by plaque stability in coronary arteries. The aim of the current study was to investigate the 5A/6A polymorphism in the MMP-3 gene and C/T polymorphism in the MMP-9 gene in patients with coronary artery disease (CAD). The study population consisted of 400 patients who underwent coronary angiography. Read More

    Conservative pharmacotherapy vs. staged percutaneous coronary intervention for non-culprit vessels in patients with ST-segment elevation myocardial infarction.
    Exp Ther Med 2016 Dec 14;12(6):4147-4153. Epub 2016 Nov 14.
    Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.
    The present study aimed to compare the effect of conservative pharmacotherapy (CP) and staged percutaneous coronary intervention (SPCI) on significant non-culprit vessels in patients with ST-segment elevation myocardial infarction (STEMI). A total of 266 male and 40 female patients were divided into two groups following their first successful PCI treatment: i) Patients in the complete revascularization (CR) group undergoing SPCI; and ii) patients in the CP group undergoing CP. Follow-up data were collected at 180 or 360 days after surgery to compare the rates of major adverse cardiovascular events (MACE), recurrent myocardial infarction, recurrent angina pectoris and MACE-free survival rates between the two groups. Read More

    Adenosine triphosphate stress (99m)Tc-methoxyisobutylisonitrile gated myocardial perfusion imaging efficacy in diagnosing stent restenosis following coronary stent implantation.
    Exp Ther Med 2016 Dec 4;12(6):3897-3904. Epub 2016 Nov 4.
    Department of Nuclear Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
    Coronary stent restenosis rate following implantation is considerably high. The adenosine stress gated myocardial perfusion imaging (G-MPI) method has been widely used in the diagnosis, risk stratification and prognosis evaluation of coronary heart disease; however, the high cost of adenosine limits its clinical application. The aim of the present study was to investigate the efficacy of adenosine triphosphate (ATP) stress (99m)Tc-methoxyisobutylisonitrile ((99m)Tc-MIBI) G-MPI for diagnosis in-stent restenosis following coronary stent implantation. Read More

    Chronic physical conditions, multimorbidity and physical activity across 46 low- and middle-income countries.
    Int J Behav Nutr Phys Act 2017 Jan 18;14(1). Epub 2017 Jan 18.
    Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London, SE5 8AZ, UK.
    Background: There are no nationally representative population-based studies investigating the relationship between physical activity, chronic conditions and multimorbidity (i.e., two or more chronic conditions) in low- and middle-income countries (LMICs), and studies on a multi-national level are lacking. Read More

    Assessment of the length of sick leave in patients with ischemic heart disease.
    BMC Cardiovasc Disord 2017 Jan 18;17(1):32. Epub 2017 Jan 18.
    Departament Català de la Salut, Servicio de farmacia, Lleida, Spain.
    Background: The prevalence of ischemic heart disease is high. Few recent studies have investigated the periods of sick leave of these patients. Our aim is to determine the length of sick leave after an acute coronary syndrome, its costs, associated factors and to assess the use of antidepressants and/or anxiolytics. Read More

    A rare case of myocardial bridge involving left anterior descending, obtuse marginal and ramus intermediate coronary arteries.
    Kardiochir Torakochirurgia Pol 2016 Dec 30;13(4):368-369. Epub 2016 Dec 30.
    Fatsa State Hospital, Ordu, Turkey.
    Myocardial bridging, a congenital coronary anomaly, is a cluster of myocardial fibers crossing over the epicardial coronary arteries. It is most frequently seen in the left anterior descending artery (LAD), and rarely involves the circumflex (CX) and right coronary artery (RCA). We report a patient with an unusual coronary bridge crossing over the left anterior descending, obtuse marginal and ramus intermediate branches. Read More

    Lessons from contemporary trials of cardiovascular prevention and rehabilitation: A systematic review and meta-analysis.
    Int J Cardiol 2017 Apr 23;232:294-303. Epub 2016 Dec 23.
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, UK.
    Background: Meta-analyses of cardiac rehabilitation trials up to 2010 showed a significant reduction in all-cause mortality but many of these trials were conducted before the modern management of acute coronary syndromes.

    Methods: We undertook a meta-analysis of contemporary randomised controlled trials published in the period 2010 to 2015, including patients with other forms of atherosclerotic cardiovascular disease, to investigate the impact of cardiovascular prevention and rehabilitation on hard outcomes including survival.

    Results: 18 trials randomising 7691 patients to cardiovascular prevention and rehabilitation or usual care were selected. Read More

    Clinical Study on efficacy of allopurinol in patients with acute coronary syndrome and its functional mechanism.
    Hellenic J Cardiol 2017 Jan 13. Epub 2017 Jan 13.
    Department of Cardiology, Pudong New Area People's Hospital, ShangHai 201200, PR China. Electronic address:
    Objective: To investigate the therapeutic effect of allopurinol treatment on acute coronary syndrome and to elucidate its possible mechanism.

    Methods: Patients with acute coronary syndrome (n=100) were recruited as research subjects in our hospital. The patients were randomly divided into two groups (allopurinol group, n = 50) and control group, n= 50). Read More

    Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention - a report from SCAAR.
    Blood Press 2017 Jan 16:1-11. Epub 2017 Jan 16.
    a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg , Sweden.
    Background: The prognostic role of hypertension on long-term survival after percutaneous coronary intervention (PCI) is limited and inconsistent. We hypothesize that hypertension increases long-term mortality after PCI.

    Methods: We analyzed data from SCAAR (Swedish Coronary Angiography and Angioplasty Registry) for all consecutive patients admitted coronary care units in Sweden between January 1995 and May 2013 and who underwent PCI due to ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI)/unstable angina (UA) or stable angina pectoris. Read More

    Unstable Angina Pectoris in a 22-year-old Female Patient.
    Kurume Med J 2017 Jan 16. Epub 2017 Jan 16.
    Department of Medicine, Kurume University School of Medicine.
    Because of the protective effect of estrogen for atherosclerosis, the prevalence of acute coronary syndrome in women before menopause is low. We report a rare case of unstable angina in a young Japanese female who had a history of cigarette smoking and contraceptive use. Her coronary stenosis was successfully treated by percutaneous coronary intervention. Read More

    The Time Course of Markers of Neutrophil Extracellular Traps in Patients Undergoing Revascularisation for Acute Myocardial Infarction or Stable Angina Pectoris.
    Mediators Inflamm 2016 15;2016:2182358. Epub 2016 Dec 15.
    Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
    Background and Aims. Neutrophil extracellular traps (NETs) have been identified in acute myocardial infarction. We assessed the time profile and association with infarct size for NETs markers in ST-elevation myocardial infarction (STEMI) and stable angina pectoris (AP). Read More

    Kudiezi injection mitigates myocardial injury induced by acute cerebral ischemia in rats.
    BMC Complement Altern Med 2017 Jan 5;17(1). Epub 2017 Jan 5.
    Central Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, 6 Zone One of Fangxingyuan, Fang Zhuang, Fengtai District, Beijing, 100078, China.
    Background: Kudiezi (KDZ) injection is commonly used in traditional Chinese medicine as treatment for cerebral infarction and angina pectoris. The present study investigated the therapeutic effects of KDZ injection on myocardial injury induced by acute cerebral ischemia and the possibly protective mechanisms.

    Methods: Rats were divided into three groups: sham, 6h-ischemia, and KDZ treatment (KDZ). Read More

    The burden of major adverse cardiac events in patients with coronary artery disease.
    BMC Cardiovasc Disord 2017 Jan 4;17(1). Epub 2017 Jan 4.
    Division of Cardiology, E-Da Hospital, I-Shou University, No. 1, Yi-Da Rd, Jiau-Shu Village, Yan-Chao District, Kaohsiung, 82445, Taiwan.
    Background: Patients with a history of cardiovascular disease are at high risk of developing secondary major adverse cardiac events (MACE). This study aimed to identify independent predictors of MACE after hospital admission which could be used to identify of high-risk patients who may benefit from preventive strategies.

    Methods: This study included 1,520 consecutive patients with coronary artery disease (CAD) (654 with acute coronary syndrome (ACS) and 866 with elective percutaneous coronary intervention (PCI) patients) who received PCI and/or stenting. Read More

    Angioscopic observation of extremely late arterial repair after intracoronary implantation of the first-generation sirolimus-eluting stents.
    Int J Cardiol 2017 Mar 21;230:488-492. Epub 2016 Dec 21.
    Department of Cardiology, Higashi-osaka City Medical Center, Osaka, Japan. Electronic address:
    Background: Arterial repair delays after intracoronary implantation of Cypher sirolimus-eluting stents (SES), a representative first-generation drug-eluting stent. It remains unclear whether this delay would catch up with bare metal stents (BMS) during extremely long observation. The aim of this study was angioscopic observation of extremely late arterial repair after Cypher SES implantation. Read More

    Patterns of inpatient care for acute myocardial infarction and 30-day, 3-month and 1-year cardiac diseases readmission rates in Spain.
    Int J Cardiol 2017 Mar 22;230:14-20. Epub 2016 Dec 22.
    Foundation Institute for Healthcare Improvement, Madrid, Spain; Cardiac Unit, Hospital San Juan, Universidad Miguel Hernández, Alicante, Spain.
    Background: Acute myocardial infarction (AMI) is a common cause of hospital discharges and readmissions. Readmissions may indicate poor patient care and avoidable health expenditure, being key in quality improvement strategies. Our aim was to analyse cardiac diseases (CDs) readmissions in patients with AMI in Spain. Read More

    The signal intensity of coronary culprit lesions on T1-weighted magnetic resonance imaging is directly correlated with the accumulation of vulnerable morphologies.
    Int J Cardiol 2017 Mar 20;231:284-286. Epub 2016 Dec 20.
    Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
    Background: In the magnetic resonance T1-weighted imaging, some investigators have shown that coronary artery high-intensity signals (HISs) are associated with vulnerable plaque morphology and an increased risk of future cardiac events. Although previous studies used different PMR (the ratio between the signal intensities of coronary plaque and cardiac muscle) cutoff values to detect HIS, the association between PMR itself and plaque morphology has not been fully investigated.

    Methods And Results: We prospectively investigated the association between PMR values and plaque morphology detected by optical coherence tomography in consecutive 106 patients with angina pectoris. Read More

    Management standards for stable coronary artery disease in India.
    Indian Heart J 2016 Dec 9;68 Suppl 3:S31-S49. Epub 2016 Dec 9.
    Department of Cardiology, AIIMS, New Delhi, India.
    Coronary artery disease (CAD) is one of the important causes of cardiovascular morbidity and mortality globally, giving rise to more than 7 million deaths annually. An increasing burden of CAD in India is a major cause of concern with angina being the leading manifestation. Stable coronary artery disease (SCAD) is characterised by episodes of transient central chest pain (angina pectoris), often triggered by exercise, emotion or other forms of stress, generally triggered by a reversible mismatch between myocardial oxygen demand and supply resulting in myocardial ischemia or hypoxia. Read More

    Impact of Paradoxical Decrease in High-Density Lipoprotein Cholesterol Levels After Statin Therapy on Major Adverse Cardiovascular Events in Patients with Stable Angina Pectoris.
    Clin Ther 2016 Dec 26. Epub 2016 Dec 26.
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Purpose: Statin therapy usually increases HDL-C levels. However, a paradoxical decrease in HDL-C levels after statin therapy is often seen in clinical settings. The relationship between a paradoxical decrease in HDL-C levels after statin therapy and adverse cardiovascular events in patients with stable angina pectoris (SAP) is not well understood. Read More

    Premature Atherosclerosis and Drug Eluting Stent Restenosis in an Adult with Osteogenesis Imperfecta.
    Int J Angiol 2016 Dec 12;25(5):e166-e168. Epub 2016 Feb 12.
    Department of Cardiology, Bayındır Hospital, Ankara, Turkey.
    Mild form of osteogenesis imperfecta (OI) may have a normal life span. However, cardiovascular complications including aortic and valvular heart disease, and coronary artery disease may complicate the life period. We presented a patient with mild form of OI and premature coronary atherosclerosis. Read More

    Non-ST Elevation Myocardial Infarction Triggered by Subclavian Steal Syndrome.
    Int J Angiol 2016 Dec 16;25(5):e37-e38. Epub 2014 Jul 16.
    Department of Cardiology, Istanbul Medicine Hospital, Istanbul, Turkey.
    Coronary-subclavian artery (SCA) steal syndrome is an uncommon phenomenon in which coronary flow is diverted into the SCA through the patent left internal mammary artery (LIMA) conduit due to critical subclavian stenosis. The prevalence of significant left SCA (LSCA) stenosis in patients, referred for coronary bypass surgery, has been reported to be 0.2 to 6. Read More

    Diagnostic and prognostic value of a careful symptom evaluation and high sensitive troponin in patients with suspected stable angina pectoris without prior cardiovascular disease.
    Atherosclerosis 2016 Nov 28. Epub 2016 Nov 28.
    Department of Cardiology, Odense University Hospital, Odense C, Denmark. Electronic address:
    Background And Aims: Typical angina pectoris (AP) and high-sensitive troponin I (hs-TnI) are independently associated with coronary artery disease (CAD) and future cardiovascular events (CVE). This study aimed to assess the individual and combined diagnostic and prognostic impact of symptoms and hs-TnI in stable chest pain patients without prior cardiovascular disease.

    Methods: During a one-year period, 487 patients with suspected stable AP underwent invasive or CT-coronary angiography (significant stenosis ≥50%). Read More

    Modeling of the Bioactivation of an Organic Nitrate by a Thiol to Form a Thionitrate Intermediate.
    Molecules 2016 Dec 25;22(1). Epub 2016 Dec 25.
    Department of Chemistry, School of Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan.
    Thionitrates (R-SNO₂) have been proposed as key intermediates in the biotransformation of organic nitrates that have been used for the clinical treatment of angina pectoris for over 100 years. It has been proposed and widely accepted that a thiol would react with an organic nitrate to afford a thionitrate intermediate. However, there has been no example of an experimental demonstration of this elementary chemical process in organic systems. Read More

    The correlation between serum total bilirubin and outcomes in patients with different subtypes of coronary artery disease.
    Clin Chim Acta 2017 Feb 23;465:101-105. Epub 2016 Dec 23.
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:
    Backgrounds: The relation between serum total bilirubin (TBi) and mortality in patients with established coronary artery disease (CAD) remains undefined. We try to investigate the role of the subtypes of CAD in the association.

    Methods: A total of 3013 patients with angiographically obstructive CAD were enrolled. Read More

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