Angew Chem Int Ed Engl 2018 Feb 23. Epub 2018 Feb 23.
Georg-August-Universitaet Goettingen, Institut fuer Organische und Biomolekulare Chemie, Tammannstr. 2, 37077, Goettingen, GERMANY.
An inexpensive, non-toxic manganese catalyst enabled unprecedented redox-neutral carbonylative annulations under ambient pressure. The manganese catalyst outperformed all other typically used base and precious metal catalysts. The outstanding versatility of the manganese catalysis manifold was reflected by ample substrate scope, setting the stage for effective late-stage manipulations under racemization-free conditions on a wealth of marketed drugs and natural products, including alkaloids, amino acids, steroids and carbohydrates. Read More