2,375 results match your criteria Aneurysmal Bone Cyst


RNA sequencing identifies a novel USP9X-USP6 promoter swap gene fusion in a primary aneurysmal bone cyst.

Genes Chromosomes Cancer 2019 Feb 14. Epub 2019 Feb 14.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Primary aneurysmal bone cyst (ABC) is a benign multiloculated cystic lesion of bone that is defined cytogenetically by USP6 gene rearrangements. Rearrangements involving USP6 are promoter swaps, usually generated by fusion of the non-coding upstream exons of different partner genes with exon 1 or 2 of USP6, thus leading to transcriptional upregulation of full-length USP6 coding sequence. Testing for USP6 rearrangements is used diagnostically to distinguish it from secondary ABC and other giant cell-rich primary bone tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gcc.22742DOI Listing
February 2019

Fibrous dysplasia with secondary aneurysmal bone cyst-a rare case report and literature review.

Oral Maxillofac Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, Center of Health Sciences, Federal University of Santa Catarina, University Campus, Trindade, Florianópolis, 88.040-370, Santa Catarina, Brazil.

Introduction: Fibrous dysplasia (FD) and aneurysmal bone cyst (ABC) are uncommon non-neoplastic intraosseous lesions, and the occurrence of concomitant FD and ABC is extremely rare.

Case Report: An 11-year-old boy presented with gradual progressive enlargement of his right zygomatic bone over 4 years prior to presentation. Computed tomography revealed a lesion with a central bony area showing a ground-glass appearance surrounded by a well-defined expansile lesion with internal septations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10006-019-00741-wDOI Listing
February 2019

[Benign tumors that cause fractures in children].

Acta Ortop Mex 2018 Sep-Oct;32(5):283-286

Hospital Regional «Ignacio Zaragoza», Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Ciudad de México. México.

Introduction: A pathological fracture is defined as that which occurs through an abnormal bone. Approximately 20,000 benign neoplasms of the musculoskeletal system are diagnosed each year. Often the pain of the fracture is the first symptom of a pathological process in the bone. Read More

View Article

Download full-text PDF

Source
February 2019
1 Read

Aneurysmal Bone Cyst-An Unusual Presentation of Wrist Pain.

J Wrist Surg 2019 Feb 13;8(1):76-79. Epub 2018 Jun 13.

Department of Orthopaedics, MLB Medical College, Jhansi, Uttar Pradesh, India.

 Aneurysmal bone cyst (ABC) is a cystic benign expansile lytic bone lesion, resembling multiple intraosseous blood-filled spaces. It is most commonly seen in the first two decades of life. Most frequent sites of involvement are metaphysis of proximal and distal femur, proximal tibia, and posterior elements of spine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1660810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358442PMC
February 2019

Understanding Unicameral and Aneurysmal Bone Cysts.

Pediatr Rev 2019 Feb;40(2):51-59

St Christopher's Hospital for Children, Philadelphia, PA.

Bone cysts in the pediatric population are often found incidentally on radiographs or after a cyst has created cortical weakness leading to a pathologic fracture. Most bone cysts are benign, are pain free, and resolve spontaneously. The most common bone cyst is unicameral 1-chamber bone cyst, also known as simple bone cyst. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/pir.2015-0128DOI Listing
February 2019

Cervical Spine Osteoblastoma with an Aneurysmal Bone Cyst in a 2-Year-Old Child: A Case Report.

Pediatr Neurosurg 2019 Jan 23:1-5. Epub 2019 Jan 23.

Department of Neurosurgery, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.

Osteoblastomas and aneurysmal bone cysts are uncommon benign tumors of the spine. Their presentation can vary between diffuse pain, restriction of neck movements, torticollis, radiculopathy, and myelopathy. Complete excision is the best treatment to achieve a cure, but recurrence is not uncommon. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/495065
Publisher Site
http://dx.doi.org/10.1159/000495065DOI Listing
January 2019
5 Reads
0.497 Impact Factor

The need for bone biopsies in the diagnosis of new bone lesions in patients with a known primary malignancy: A comparative review of 117 biopsy cases.

J Bone Oncol 2019 Feb 18;14:100213. Epub 2018 Dec 18.

Department of Orthopedics, Zhongshan Hospital, Fudan University, 180# Fenglin Road, Xuhui district, Shanghai, China.

Objective: This study used a clinical dataset to investigate the proportion of the newly found bone lesions in malignant patients diagnosed by biopsy as being benign, malignant but unrelated to the primary malignancy, or bone metastases of the primary malignancy. The clinical factors that might affect the correlation between bone lesions and the primary malignancy were also analyzed. It is expected to obtain some information contributing to the clinical decision-making regarding the need for biopsy of these lesions from the research results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbo.2018.100213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329701PMC
February 2019
1 Read

Aneurysmal bone cyst of the frontal bone - A radiologic-pathologic correlation.

J Radiol Case Rep 2018 Jul 31;12(7):16-24. Epub 2018 Jul 31.

Department of Skeletal and visceral Radiology, Hôpital Lariboisère, Paris, France.

We present a case of 27-year-old female who presented for a progressive frontal swelling with ipsilateral headache. Subsequent CT scan revealed an extradural and expansile multiloculated mass with thin and strongly enhanced septations and MRI evaluation showed internal hyperintensity on T2 with no restriction of diffusion and confirmed the multiple cystic spaces with enhancing septations and rare hemorrhagic fluid-fluid levels. Surgery was performed and diagnosis of aneurysmal bone cyst was made on frozen section. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3941/jrcr.v12i7.3344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311178PMC

Recurrent Aneurysmal Bone Cyst of the Distal Fibula Treated with Denosumab and Curettage.

Case Rep Oncol Med 2018 9;2018:1574343. Epub 2018 Dec 9.

Department of Sarcoma, Moffitt Cancer Center, Tampa, FL, USA.

We report the case of a 13-year-old girl with multiple recurrences of an aneurysmal bone cyst of the distal fibula successfully treated with denosumab and curettage. Aneurysmal bone cysts are locally aggressive lesions with high rates of recurrence. The novel use of denosumab with curettage in a long bone showed a favorable outcome with no adverse events or signs of recurrence three years after treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/1574343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304848PMC
December 2018

Giant cell reparative granuloma of the scapula: report of a case and literature review.

Skeletal Radiol 2019 Jan 4. Epub 2019 Jan 4.

Department of Orthopedics and Orthopedic Oncology, University of Padova, Via Giustiniani 3, Padova, Italy.

Giant cell reparative granulomas (GCRGs) are non-neoplastic inflammatory lesions, usually observed in the maxilla, mandible or small bones of the hands and feet. These lesions present a wide range of morphology and the misinterpretation with other giant cell lesions can often occur. We report the case of a 47-year-old woman with GCRG in the left scapula, presenting some uncommon features: the location (scapula) and age at presentation, the lack of underlying bone disease such as Paget's disease or fibrous dysplasia, the large aggressive expansile aspect of the lesion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00256-018-3132-0DOI Listing
January 2019
3 Reads

Soft tissue aneurysmal bone cyst: six new cases with imaging details, molecular pathology, and review of the literature.

Skeletal Radiol 2019 Jan 2. Epub 2019 Jan 2.

Department of Radiology, C-2-S, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands.

Objective: Aneurysmal bone cysts (ABC) rarely present in soft tissue locations (STABC). The 30 cases of STABC reported in the English literature were reviewed. Six new cases retrieved from the files of the Netherlands Committee on Bone Tumors were compared to the six cases described in the radiological literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00256-018-3135-xDOI Listing
January 2019
1 Read

An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencing.

Genes Chromosomes Cancer 2019 02 24;58(2):88-99. Epub 2018 Dec 24.

Department of Pathology, The Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom.

The last decade has seen the majority of primary bone tumor subtypes become defined by molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p.G34W), chondroblastoma (H3F3B p. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/gcc.22699
Publisher Site
http://dx.doi.org/10.1002/gcc.22699DOI Listing
February 2019
6 Reads

Chondromyxoid fibroma with a secondary aneurysmal bone cyst of the distal radius: A case report.

J Orthop Sci 2018 Dec 20. Epub 2018 Dec 20.

Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jos.2018.11.017DOI Listing
December 2018

Primary aneurysmal bone cyst with a novel SPARC-USP6 translocation identified by next-generation sequencing.

Cancer Genet 2018 Dec 20;228-229:12-16. Epub 2018 Jul 20.

Faculty of Medicine, Institute of Pathology, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.

Aneurysmal bone cyst (ABC) is a benign but locally aggressive, mostly pediatric neoplasm, with characteristic USP6 gene rearrangement that distinguishes it from a secondary ABC and other primary bone tumors. With the advent of next-generation sequencing (NGS) technology, several hitherto unknown USP6 fusion partners have been identified in ABC. Accordingly, we present a case of an 18-year-old male with a solid sub-periosteal primary ABC in the diaphysis of the left femur. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cancergen.2018.07.001DOI Listing
December 2018
2 Reads

Adjuvant MRI-guided percutaneous cryoablation treatment for aneurysmal bone cyst.

Skeletal Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD, 21287, USA.

Aneurysmal bone cysts are benign, expansile, lytic bone lesions that behave in a locally aggressive manner. Although radiography and computed tomography (CT) can detect the lesion, magnetic resonance imaging (MRI) is ideal for the demonstration of characteristic fluid-fluid levels, extent, and margins. Treatment typically consists of open surgical curettage with the addition of local adjuvants and bone grafting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00256-018-3115-1DOI Listing
December 2018
4 Reads

Massive aneurysmal bone cyst of the skull base treated with denosumab.

Head Neck 2018 Dec 26;40(12):E107-E113. Epub 2018 Nov 26.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Aneurysmal bone cysts are rare, benign expansile tumors most commonly involving long bones and vertebrae in patients younger than age 20. Skull base involvement is rare. Aneurysmal bone cysts shares radiological and histological features with other bone tumors, posing a diagnostic challenge. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/hed.25438
Publisher Site
http://dx.doi.org/10.1002/hed.25438DOI Listing
December 2018
13 Reads

Percutaneous albumin/doxycycline injection versus open surgery for aneurysmal bone cysts in the mobile spine.

Eur Spine J 2018 Nov 23. Epub 2018 Nov 23.

Department of Orthopaedics, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.

Purpose: This study aimed to validate the safety and effectiveness of percutaneous doxycycline/albumin injection for spinal aneurysmal bone cysts (ABCs) as an alternative to open surgery.

Methods: From January 2000 to December 2016, 25 patients who had no/minor neurological deficits (modified Frankel scale D or E) and acceptable local stability (spinal instability neoplastic score < 12) were included in the study, of whom 14 were treated with percutaneous doxycycline/albumin injection (injection group) and 11 were treated with open surgery (surgery group). The demographic and clinical information of the injection and surgery groups were recorded and compared. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00586-018-5836-1DOI Listing
November 2018
13 Reads

All-endoscopic management of benign bone lesions; a case series of 26 cases with minimum of 2 years follow-up.

SICOT J 2018 22;4:50. Epub 2018 Nov 22.

Orthopedics & Trauma Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Purpose: Assessment of the functional and oncologic outcomes regarding endoscopic curettage of different benign bone tumor types within variable anatomic locations.

Patients And Methods: During the period between February 2012 and December 2016, 26 patients with symptomatic intra-osseous benign bony lesions were included. The age ranged from 3 up to 49 years (mean 20), of 14 females and 12 males. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/sicotj/2018041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250076PMC
November 2018
8 Reads

PERCUTANEOUS TREATMENT OF ANEURYSMAL BONE CYST WITH CALCITONIN AND METHYLPREDNISOLONE.

Acta Ortop Bras 2018 ;26(5):314-319

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: To introduce the intralesional calcitonin and methylprednisolone percutaneous injection method, which results in the promotion of primary aneurysmal bone cyst (ABC) healing.

Methods: A retrospective cohort study involving 76 patients diagnosed with ABC was performed between 2005 and 2014. Patients treated with calcitonin and methylprednisolone injection and who underwent more than 2 years of follow-up were considered eligible for the study (n=47). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1413-785220182605201423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220667PMC
January 2018

Preliminary Results of Highly Injectable Bi-Phasic Bone Substitute (CERAMENT) in the Treatment of Benign Bone Tumors and Tumor-like Lesions.

Open Med (Wars) 2018 22;13:487-492. Epub 2018 Oct 22.

Department of Orthopaedics, Traumatology and Orthopaedic Oncology, Pomeranian Medical University in Szczecin, Poland.

Background: CERAMENT™|BONE VOID FILLER is an injectable and moldable ceramic bone substitute material intended for bone voids. The material consists of hydroxyapatite and calcium sulfate hemihydrate. The aim of this study is to present the first long-term results following open curettage of benign bone tumors and tumor-like lesions and void filling with this novel injectable and synthetic bone graft. Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/med.2018.13.issue-1/med-2018
Publisher Site
http://dx.doi.org/10.1515/med-2018-0072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6227780PMC
October 2018
12 Reads

Atypical presentation of a solid-variant orbital aneurysmal bone cyst with a literature review.

Neurochirurgie 2018 Dec 6;64(6):431-433. Epub 2018 Nov 6.

School of Medicine, University of Connecticut, 263, Farmington Avenue, Farmington, Connecticut, 06030, USA; Department of Surgery, Division of Ophthalmology, University of Connecticut Health, 263, Farmington Avenue, Farmington, Connecticut, 06030, USA. Electronic address:

Introduction: Aneurysmal bone cysts (ABCs) are rare, rapidly expansile, benign, vascular lesions capable of causing local bone destruction. The majority of cases present as multi-cystic lytic lesions (with solid-variant ABCs representing<10% of all presentations) of the long bones or vertebrae, rarely occurring in the head/neck region.

Clinical Case: A 44-year-old female presented with nine days of worsening pain, ptosis and proptosis in the right eye. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00283770183031
Publisher Site
http://dx.doi.org/10.1016/j.neuchi.2018.10.001DOI Listing
December 2018
7 Reads

[Anterior stabilization of the CI-CIII vertebrae after transoral removal of an aggressive aneurysmal bone cyst of the CII vertebra (a case report and literature review)].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(5):111-118

Priorov National Medical Research Center of Traumatology and Orthopedics, Moscow, Russia.

Treatment of patients with atlantoaxial instability caused by various diseases of the skull base and craniovertebral junction combined with ventral compression of the brainstem is a complex issue that is ambiguously resolved in different ways. We present a case of stepped treatment, the most important component of which was successful transoral removal of an aggressive aneurysmal bone cyst of the CII vertebra with anterior CI-CIII segment stabilization using an individual system, which was performed through the same approach.

Clinical Case: A 31-year-old male patient presented with destruction of the CII body and odontoid process affected by an aggressive aneurysmal bone cyst causing disintegration of the CII posterior wall and odontoid process, which clinically manifested by constricted motion and pain in the cervical spine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/neiro201882051111DOI Listing
January 2018
10 Reads

Complete resolution of a cervical spine aneurysmal bone cyst after single session of endovascular embolization: Case report.

Interv Neuroradiol 2018 Nov 8:1591019918810534. Epub 2018 Nov 8.

2 Department of Neurological Surgery, University of South Florida, Tampa, USA.

Treatment options for aneurysmal bone cysts include intralesional curettage, segmental excision, en bloc resection and endovascular embolization. The most commonly used treatment is intralesional curettage and selective arterial embolization is normally an adjunctive therapy, not a definitive treatment. We report a case of a C1 lateral mass aneurysmal bone cyst treated with a single session of endovascular embolization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1591019918810534DOI Listing
November 2018

Primary aneurysmal bone cyst of the mandibular condyle with USP6-CDH11 fusion.

Pathol Res Pract 2018 Nov 2. Epub 2018 Nov 2.

Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada; Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address:

Primary aneurysmal bone cyst (ABC) is a cystic bone neoplasm characterized by disease-defining gene fusions involving the USP6/Tre2 gene. The literature describing gnathic ABC is limited. This case report describes a 27-year-old man presenting with a long-standing left-sided facial asymmetry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prp.2018.10.038DOI Listing
November 2018
1 Read

Histopathology of giant cell tumors of the bone: With special emphasis on fibrohistiocytic and aneurysmal bone cyst like components.

Acta Orthop Traumatol Turc 2018 Nov 1. Epub 2018 Nov 1.

Medipol University, Department of Pathology, Istanbul, Turkey. Electronic address:

Objective: The aim of this study was to define histopathological features of giant cell tumor of bone, especially accompanying fibrohistiocytic or aneurysmal bone cyst like components, in the light of our institutions experience.

Methods: A total of 120 cases (64 females and 56 males; mean age: 36.2 (12-80)) with 'GCT' diagnosed between the years 1996-2016 were included in this retrospective analysis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S1017995X173029
Publisher Site
http://dx.doi.org/10.1016/j.aott.2018.10.007DOI Listing
November 2018
9 Reads

Secondary Aneurysmal Bone Cyst in a Craniofacial Fibrous Dysplasia: Case Report.

Brain Tumor Res Treat 2018 Oct;6(2):86-91

Department of Neurosurgery, Konkuk University Medical Center, Seoul, Korea.

Aneurysmal bone cyst (ABC) is a rare non-neoplastic bone lesion that involves mostly the long bones and vertebrae and may occur very rarely in the craniofacial bones. ABCs may occur as secondary bony pathologies in association with various benign and malignant bone tumors and with fibrous dysplasia (FD). FD is a common non-neoplastic bony pathology mostly affecting craniofacial bones. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14791/btrt.2018.6.e15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212691PMC
October 2018
1 Read

Chondroblastoma of the Foot: 40 Cases From a Single Institution.

J Foot Ankle Surg 2018 Nov - Dec;57(6):1105-1109

Professor, Department of Orthopedic and Orthopedic Oncology, University of Padova, Padova, Italy. Electronic address:

Chondroblastoma (CB) of the foot is a rare lesion. The purpose of this report was to report a large series from a single institution to analyze clinical, radiographic, and histologic characteristics; treatment; and local recurrence. We present 40 patients (30 males, 10 females; mean age 25 years) diagnosed and treated for CB of the foot from 1975 to 2012. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10672516183019
Publisher Site
http://dx.doi.org/10.1053/j.jfas.2018.05.005DOI Listing
February 2019
10 Reads

Fluid-Fluid Levels in Aneurysmal Bone Cysts.

J Pediatr 2019 Jan 27;204:317. Epub 2018 Sep 27.

Department of Radiology Auckland City Hospital Grafton, Auckland, New Zealand; Department of Radiology Hospital Nueve de Octubre Valencia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2018.08.081DOI Listing
January 2019
5 Reads
3.790 Impact Factor

Aneurysmal bone cyst of the clavicle: a series of 13 cases.

J Shoulder Elbow Surg 2019 Jan 20;28(1):71-76. Epub 2018 Sep 20.

Musculoskeletal Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA. Electronic address:

Background: Aneurysmal bone cyst (ABC) is a benign but locally aggressive bone tumor occurring most commonly in the first 2 decades of life. The clavicle is a rare location for tumors, and ABCs of the clavicle have been sparsely described in the literature. We present the largest known series of ABCs of the clavicle to describe this rare condition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jse.2018.06.036DOI Listing
January 2019
3 Reads
2.290 Impact Factor

Unicameral bone cysts: Current concepts.

Ann Med Surg (Lond) 2018 Oct 28;34:43-49. Epub 2018 Jun 28.

Department of Pathology & Laboratory Medicine, Aga Khan University, Karachi, Pakistan.

Unicameral bone cysts (UBC) or simple/solitary bone cysts are benign fluid filled cavities that enlarge over time, resulting in thinning of the bone. Usually these cysts are reported in the metaphyseal areas of long bones with open physes. 85% of UBCs occur almost exclusively in children and adolescents. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S20490801183012
Publisher Site
http://dx.doi.org/10.1016/j.amsu.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138978PMC
October 2018
7 Reads

[Chest wall hamartoma of infancy: a clinicopathologic observation of five cases].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):706-709

Department of Pathology, Kunming Children's Hospital, Kunming 650228, China.

To study the clinicopathologic features, diagnosis and differential diagnosis of chest wall hamartoma of infancy. The clinical data, histopathologic features and immunophenotype of five chest wall hamartomas were analyzed, and the relevant literature was reviewed. The patients' age ranged from seven months and eight days to 20 months at time of resection, although the lesions were detected in the neonatal period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.09.011DOI Listing
September 2018
1 Read

A rare case of giant osteoblastoma of the sacrum.

Orthopade 2018 Sep 7. Epub 2018 Sep 7.

Department of Orthopedics, Artificial Joints Engineering and Technology Research Center of Jiangxi Province and Multidisciplinary Therapy Center of Musculoskeletal Tumor, The First Affiliated Hospital of Nanchang University, 330006, Nangchang, Jiangxi, China.

Background: An osteoblastoma is a rare benign bone tumor characterized by formation of osteoid tissue and primitive bone and occurs more often in men than in women. They are often secondary to an osteoid osteoma and can be located at any site on the skeleton. Lesions generally involve the posterior elements of the spine, such as the pedicle and the lamina. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00132-018-3638-0DOI Listing
September 2018
13 Reads

Updates in Primary Bone Tumors: Current Challenges and New Opportunities in Cytopathology.

Authors:
Xiaohua Qian

Surg Pathol Clin 2018 Sep;11(3):657-668

Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

The review summarizes the current diagnostic challenges in fine-needle aspiration of primary bone tumors, with focus on the application of new molecular and immunohistochemical techniques in the diagnosis of giant cell-rich neoplasms, chondrosarcomas, and notochordal tumors. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18759181183003
Publisher Site
http://dx.doi.org/10.1016/j.path.2018.06.004DOI Listing
September 2018
16 Reads

Aneurysmal Bone Cyst of 3rd Metacarpal, Management and Follow-up: A Case Report.

J Orthop Case Rep 2018 Mar-Apr;8(2):9-12

Consultant Orthopaedic Hand Surgeon, Lilavati Hospital and Research Centre Mumbai, Maharashtra, India.

Introduction: Aneurysmal bone cysts of the hand are rare, and only few cases are reported in scientific literature. We report a case of aneurysmal bone cyst of 3rd metacarpal treated at our tertiary care hospital, Mumbai.

Case Report: A 13-year-old young female presented with pain and progressive increase in swelling over the dorsum of the right hand for 7-months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13107/jocr.2250-0685.1024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114219PMC
September 2018
6 Reads

Spheno-Orbital Aneurysmal Bone Cyst in a 10-Month-Old Infant.

World Neurosurg 2018 Sep 2;117:371-376. Epub 2018 Jul 2.

Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Department of Neurosurgery, Children's Hospital of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address:

Background: Aneurysmal bone cysts are benign bone lesions affecting long bones and vertebrae; only 2%-6% have cranial involvement, and even fewer show sphenoid or intraorbital involvement. Gross total resection is the treatment of choice.

Case Description: A 10-month-old girl presented with unilateral proptosis and no neurologic deficits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2018.06.193DOI Listing
September 2018
14 Reads

USP6 Confers Sensitivity to IFN-Mediated Apoptosis through Modulation of TRAIL Signaling in Ewing Sarcoma.

Mol Cancer Res 2018 Dec 21;16(12):1834-1843. Epub 2018 Aug 21.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania.

: Ewing sarcoma is the second most common sarcoma of the bone, afflicting predominantly the pediatric population. Although patients with localized disease exhibit favorable survival rates, patients with metastatic disease suffer a dismal 5-year rate of approximately 25%. Thus, there is a great need to develop treatments to combat the disseminated disease. Read More

View Article

Download full-text PDF

Source
http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
Publisher Site
http://dx.doi.org/10.1158/1541-7786.MCR-18-0289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279478PMC
December 2018
18 Reads

[Treatment of proximal femoral benign lesions by proximal femoral nail anti-rotation combined with curettage and bone graft through the Watson-Jones approach].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Jul;32(7):893-898

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

Objective: To evaluate the feasibility and effectiveness of proximal femoral nail anti-rotation (PFNA) combined with curettage and bone graft through Watson-Jones approach in the treatment of proximal femur benign tumors and tumor like lesions.

Methods: The clinical data of 38 patients with benign tumors and tumor like lesions in the proximal femur who were treated through the Watson-Jones approach with PFNA combined with curettage and bone graft between January 2008 and January 2015 were retrospective analysed. There were 24 males and 14 females with an average age of 28 years (range, 15-57 years). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7507/1002-1892.201801128DOI Listing
July 2018
11 Reads

Histone H3K36M mutation and trimethylation patterns in chondroblastoma.

Histopathology 2019 Jan 4;74(2):291-299. Epub 2018 Nov 4.

Department of Pathology, Memorial Sloan Kettering Cancer Center, Great Neck, NY, USA.

Aims: Histones are essential components of chromatin, and mutations in histones lead to alterations in methylation and acetylation, which play an important role in tumorigenesis. Most of the chondroblastomas harbour the H3K36M mutation. With the availability of a mutation-specific antibody, we sought to assess the sensitivity of this antibody and the alterations of histone methylation in a series of chondroblastoma cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/his.13725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298805PMC
January 2019
17 Reads

The Use of Triphasic Bone Graft for the Treatment of Pediatric Bone Cysts: Experience at 2 Institutions.

Orthopedics 2018 Sep 10;41(5):e705-e712. Epub 2018 Aug 10.

Unicameral/aneurysmal bone cysts can lead to pain, fracture, and limb deformity. In this study, the authors evaluated the outcome of triphasic bone graft to treat unicameral/aneurysmal bone cysts. They retrospectively evaluated 41 immature patients from a prospectively enrolled cohort from 2 institutions treated from May 9, 2007, to November 1, 2014. Read More

View Article

Download full-text PDF

Source
https://www.healio.com/doiresolver?doi=10.3928/01477447-2018
Publisher Site
http://dx.doi.org/10.3928/01477447-20180806-02DOI Listing
September 2018
9 Reads

Recurrent juvenile psammomatoid ossifying fibroma with secondary aneurysmal bone cyst of the maxilla: a case report and review of literature.

Clin Pract 2018 Jul 24;8(3):1085. Epub 2018 Jul 24.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Juvenile ossifying fibroma is a benign fibro-osseous lesion commonly affecting the extra-gnathic craniofacial skeleton of the young individuals. The psammomatoid and trabecular variants are its two histopathological subtypes having distinctive clinico-pathological characteristics. Secondary aneurysmal bone cysts are frequently reported to arise in the pre-existing fibro-osseous lesions but rarely reported in the psammmomatoid variant of the juvenile ossifying fibroma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4081/cp.2018.1085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060481PMC
July 2018
6 Reads

Denosumab in patients with aneurysmal bone cysts: A case series with preliminary results.

Tumori 2018 Oct 8;104(5):344-351. Epub 2018 Aug 8.

1 Chemotherapy Unit, IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy.

Purpose:: Aneurysmal bone cyst (ABC) is a rare skeletal tumor usually treated with surgery/embolization. We hypothesized that owing to similarities with giant cell tumor of bone (GCTB), denosumab was active also in ABC.

Methods:: In this observational study, a retrospective analysis of ABC patients treated with denosumab was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300891618784808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247581PMC
October 2018
15 Reads

Aneurysmal Bone Cyst of the Maxillary Sinus with USP6 Rearrangement: Case Report of a Rare Entity and Review of the Literature.

Head Neck Pathol 2018 Aug 3. Epub 2018 Aug 3.

Department of Pathology, The University of Chicago Medical Center, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA.

Aneurysmal bone cysts (ABCs) are benign lesions which most frequently occur in the long bones of pediatric patients. Long thought to be reactive, recent molecular advances have demonstrated that the majority of primary ABCs harbor rearrangements of the USP6 gene, confirming their neoplastic nature. Secondary ABCs arising from other lesions do not demonstrate this recurrent genetic anomaly. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12105-018-0956-9
Publisher Site
http://dx.doi.org/10.1007/s12105-018-0956-9DOI Listing
August 2018
13 Reads

Concomittant fibrous dysplasia with aneurysmal bone cyst formation within the skull, humerus and rib.

J Surg Case Rep 2018 Jul 21;2018(7):rjy180. Epub 2018 Jul 21.

Department of Neurological Surgery, University of California, Riverside School of Medicine, Riverside, CA, USA.

Polyostotic fibrous dysplasia (FD) is a rare pathology characterized by the abnormal and gradual replacement of normal bone (calcium hydroxylapatite of osteoid matrix) with fibrous connective tissue. Aneurysmal bone cyst (ABC) is a tumor-like benign lesion with blood-filled cavities that can affect virtually any bone in the body. We report on a 20-year-old male presenting with an extremely rare pathology of FD with ABC formation of the skull, fourth rib and humerus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jscr/rjy180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055640PMC
July 2018
4 Reads

Solid aneurysmal bone cyst of the humerus mimics metastasis or brown tumor.

Clin Imaging 2018 Nov - Dec;52:117-122. Epub 2018 Jul 24.

Department of Orthopedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States of America.

Solid aneurysmal bone cyst (ABC) is a rare subtype of ABC that most commonly involves the small bones of the hands or feet. We present a case of a solid ABC of the distal humerus in a 52-year-old man with a history of chronic kidney disease and renal cell carcinoma. On imaging with plain radiographs, CT, and MRI, this expansile lucent lesion with solid internal enhancement had an appearance that overlapped with metastasis or brown tumor of hyperparathyroidism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinimag.2018.07.020DOI Listing
January 2019
4 Reads
0.600 Impact Factor

Treatment of aneurysmal bone cysts using endoscopic curettage.

BMC Musculoskelet Disord 2018 Jul 27;19(1):268. Epub 2018 Jul 27.

Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.

Background: Although aneurysmal bone cysts (ABCs) are benign tumours, they have the potential to be locally aggressive. Various treatment approaches, such as en bloc resection, open curettage, radiotherapy, sclerotherapy, and embolization have been proposed, but the most appropriate treatment should be selected after considering the risk of tumour recurrence and treatment complications. Endoscopic curettage (ESC) may be a less invasive alternative to open curettage for ABC treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12891-018-2176-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064064PMC
July 2018
2 Reads

Diagnostic tools in the differential diagnosis of giant cell-rich lesions of bone at biopsy.

Oncotarget 2018 Jul 10;9(53):30106-30114. Epub 2018 Jul 10.

Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.

The diagnosis of giant cell-rich lesions of bone can be challenging if radiological findings are ambiguous and tissue of the biologically deciding component is underrepresented in biopsy specimens. The frequent association of giant cell tumor of bone (GCT) and chondroblastoma (CB) with (secondary) aneurysmal bone cysts (ABC) may further impede correct classification. The present study evaluates the potentials and limitations of mutation-specific histone H3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.25725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059026PMC
July 2018
12 Reads

Metacarpal Aneurysmal Bone Cyst En Bloc Resection Reconstructed With Osteoarticular Allograft.

J Hand Surg Am 2018 Jul 14. Epub 2018 Jul 14.

Anatomy Department, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.

Aneurysmal bone cysts are large lytic lesions that appear most often around metaphyseal bone. The lesions are locally aggressive with high recurrence rates. Therefore, wide resection is commonly necessary, leading to challenging reconstruction of the defect, especially when the articular surface is involved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhsa.2018.06.003DOI Listing
July 2018
10 Reads

Primary malignancy in giant cell tumor of thoracic vertebrae: A case report.

Medicine (Baltimore) 2018 Jul;97(28):e11484

Department of Radiology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Rationale: Primary malignancy in giant cell tumor of bone (PMGCTB) is extremely unusual. PMGCTB in the thoracic vertebrae is particularly rare.

Patients Concerns: A 23-year-old man was admitted with a chief complaint of chest pain associated with cough for approximately 3 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000011484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076027PMC
July 2018
18 Reads