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    Total Endovascular Repair of Post-dissection Aortic Arch Aneurysm With Chimney Technique.
    Ann Thorac Surg 2017 Mar;103(3):e241-e243
    Department of Cardiac Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:
    Open surgery remains the standard procedure for treatment of aortic arch pathologies. However, total endovascular repair can be a safe option for patients who are poor candidates for surgery because of compromised physiology. We report the case of a 63-year-old man with a post-dissection aortic arch aneurysm. Read More

    Durable outcomes of thoracic endovascular aortic repair with Zenith TX1 and TX2 devices.
    J Vasc Surg 2017 Feb 16. Epub 2017 Feb 16.
    Department of Vascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio; Academic Department of Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio. Electronic address:
    Objective: Long-term data regarding the safety and durability of thoracic endovascular aortic repair (TEVAR) are limited. The study objective was to evaluate the long-term outcomes of TEVAR in high-risk patients with descending thoracic aortic pathology.

    Methods: High-risk patients were treated with thoracic endografts (2001-2011) under a prospective, physician-sponsored, investigational device exemption trial. Read More

    Outcomes of thoracic endovascular aortic repair using aortic arch chimney stents in high-risk patients.
    J Vasc Surg 2017 Feb 16. Epub 2017 Feb 16.
    Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, Fla.
    Background: Aortic arch disease is a challenging clinical problem, especially in high-risk patients, in whom open repair can have morbidity and mortality rates of 30% to 40% and 2% to 20%, respectively. Aortic arch chimney (AAC) stents used during thoracic endovascular aortic repair (TEVAR) are a less invasive treatment strategy than open repair, but the current literature is inconclusive about the role of this technology. The focus of this analysis is on our experience with TEVAR and AAC stents. Read More

    Outcome of endovascular repair for intact and ruptured thoracic aortic aneurysms.
    J Vasc Surg 2017 Feb 16. Epub 2017 Feb 16.
    Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University, Uppsala, Sweden. Electronic address:
    Objective: The objective of this study was to assess long-term outcome after thoracic endovascular aortic repair (TEVAR) for thoracic aortic aneurysm (TAA).

    Methods: All patients who underwent TEVAR for TAA at Uppsala University Hospital from December 1999 to December 2014 were included. Characteristics of the patients and outcome data were collected from medical records, national population registry, and cause of death registry. Read More

    Transthoracic Echocardiography: Pitfalls and Limitations as Delineated at Cardiac CT and MR Imaging.
    Radiographics 2017 Feb 17:160105. Epub 2017 Feb 17.
    From the Department of Diagnostic Imaging, Kaiser Permanente Los Angeles Medical Center, 1505 N Edgemont Ave, Basement, Los Angeles, CA 90027.
    Transthoracic echocardiography ( TTE transthoracic echocardiography ) is a critical tool in the field of clinical cardiology. It often serves as one of the first-line imaging modalities in the evaluation of cardiac disease owing to its low cost, portability, widespread availability, lack of ionizing radiation, and ability to evaluate both anatomy and function of the heart. Consequently, a large majority of patients undergoing a cardiac computed tomography (CT) or magnetic resonance (MR) imaging examination will have a TTE transthoracic echocardiography available for review. Read More

    Endovascular repair of bilateral common iliac artery aneurysms using GORE Excluder iliac branch endoprosthesis without aortobi-iliac stent graft conjunction: A case report.
    Medicine (Baltimore) 2017 Feb;96(7):e5977
    aVascular Surgery and Organ Transplant Unit, University Hospital of Catania, Via Santa Sofia, Catania bVascular Surgery Unit, Guzzardi Hospital of Vittoria, Via Papa Giovanni XXIII, Vittoria cDepartment of Medical and Surgical Sciences and Advanced Technologies, University Hospital of Catania, Via Santa Sofia, Catania dDepartment of Surgical Specialties, University Hospital of Catania, Via Santa Sofia, Catania, Italy.
    Introduction: Bilateral common iliac artery (CIA) aneurysm (CIAA) is a rare entity. In the past decade, different endovascular approaches have been adopted for patients with several comorbidities or unfit for open repair (OR). Recently, the use of iliac branch stent graft has been proposed, resulting in satisfactory patency rates and decrease in morbidity. Read More

    Thoracoabdominal aortic replacement for Crawford extent II aneurysm after thoracic endovascular aortic repair.
    J Thorac Dis 2017 Jan;9(1):64-69
    Department of Cardiovascular Surgery, Beijing Aortic Disease Centre, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Engineering Research Centre for Vascular Prostheses, Beijing 100029, China.
    Background: The surgical treatment of Crawford extent II aneurysms after thoracic endovascular aortic repair (TEVAR) remains challenging, because of the need to remove the failed endograft and the complexity of the aortic reconstruction. We retrospectively reviewed our experience with surgical management of Crawford extent II aneurysms after TEVAR using thoracoabdominal aortic replacement (TAAR).

    Methods: Eleven patients (10 males, 1 female) with Crawford extent II aneurysm after TEVAR were treated with TAAR between August 2012 and May 2015. Read More

    Transient atrial fibrillation after open abdominal aortic revascularization surgery is associated with increased length of stay, mortality, and readmission rates.
    J Vasc Surg 2017 Feb 9. Epub 2017 Feb 9.
    Department of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Ill; One:MAP Section of Surgical Analytics, Department of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Ill. Electronic address:
    Background: It is well established that transient postoperative atrial fibrillation (TPAF) is associated with adverse postoperative outcomes after major cardiac and noncardiac operations. The purpose of this study was to elucidate the incidence, impact, and risk factors associated with the development of TPAF in patients undergoing revascularization surgery for occlusive diseases of the abdominal aorta and its branches (AAB).

    Methods: By use of the Healthcare Cost and Utilization Project State Inpatient Database from Florida and California, patients who underwent open revascularization of AAB between 2006 and 2011 were identified. Read More

    Patient-specific assessment of hemodynamics by computational fluid dynamics in patients with bicuspid aortopathy.
    J Thorac Cardiovasc Surg 2017 Jan 11. Epub 2017 Jan 11.
    Division of Cardiovascular Surgery, Department of Surgery, Jichi Medical University, Saitama, Japan.
    Objective: Hemodynamics related to eccentric blood flow may factor into the development of bicuspid aortic valve aortopathy. We investigated wall shear stress distribution by means of magnetic resonance imaging-based computational fluid dynamics in patients with a bicuspid aortic valve.

    Methods: Included were 12 patients with a bicuspid aortic valve (aortic stenosis, n = 11; root enlargement, n = 1). Read More

    Surgical Outcomes of Chronic Descending Dissections: Type I Versus III DeBakey.
    Ann Thorac Surg 2017 Feb 9. Epub 2017 Feb 9.
    Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, New York.
    Background: We evaluated the results of open operation for the treatment of descending thoracic aneurysm (DTA) and thoracoabdominal aortic aneurysm (TAAA) in patients with DeBakey type I versus type III chronic aortic dissection.

    Methods: We reviewed our institutional aortic database and compared the results of open repair in patients with type I versus type III chronic aortic dissection. Between 1997 and 2015, 726 patients underwent open DTA or TAAA repair at our institution. Read More

    [Clinical analysis of 24 cases of aortic dissection during pregnancy].
    Zhonghua Fu Chan Ke Za Zhi 2017 Jan;52(1):32-39
    Department of Obstetrics and Gynecology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China.
    Objective: To investigate the management and perinatal outcome of aortic dissection during pregnancy. Methods: 24 pregnant women with aortic dissection who delivered in Beijing Anzhen Hospital Affiliated to Capital Medical University from January 1st, 2006 to February 29th, 2016 were recruited. The clinical data, the management and the perinatal outcome were analyzed retrospectively. Read More

    A novel SMAD3 mutation caused multiple aneurysms in a patient without osteoarthritis symptoms.
    Eur J Med Genet 2017 Feb 7. Epub 2017 Feb 7.
    Surgical Research Center, GIGA-R, Belgium; Department of Cardiovascular and Thoracic Surgery, University Hospital of Liège, Belgium.
    Heterozygous mutations in the SMAD3 gene were recently described as the cause of a form of non-syndromic familial aortic thoracic aneurysm and dissection (FTAAD) transmitted as an autosomal dominant disorder and often associated with early-onset osteoarthritis. This new clinical entity, called aneurysms-osteoarthritis syndrome (AOS) or Loeys-Dietz syndrome 3 (LDS3), is characterized by aggressive arterial damages such as aneurysms, dissections and tortuosity throughout the arterial tree. We report, here, the case of a 45 year-old man presenting multiple visceral arteries and abdominal aortic aneurysms but without dissection of the thoracic aorta and without any sign of osteoarthritis. Read More

    Three-dimensional parametric modeling of bicuspid aortopathy and comparison with computational flow predictions.
    Artif Organs 2017 Feb 10. Epub 2017 Feb 10.
    Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT.
    Bicuspid aortic valve (BAV)-associated ascending aneurysmal aortopathy (namely "bicuspid aortopathy") is a heterogeneous disease making surgeon predictions particularly challenging. Computational flow analysis can be used to evaluate the BAV-related hemodynamic disturbances, which likely lead to aneurysm enlargement and progression. However, the anatomic reconstruction process is time consuming so that predicting hemodynamic and structural evolution by computational modeling is unfeasible in routine clinical practice. Read More

    Glycated Hemoglobin Is Associated With the Growth Rate of Abdominal Aortic Aneurysms: A Substudy From the VIVA (Viborg Vascular) Randomized Screening Trial.
    Arterioscler Thromb Vasc Biol 2017 Feb 9. Epub 2017 Feb 9.
    From the Elitary Research Centre of Individualized Medicine in Arterial Disease (K.L.K., L.M.R., J.S.L.), Department of Cardiac, Thoracic, Vascular Surgery (K.L.K., J.S.L.); The Danish Diabetes Academy (K.L.K.), and Department of Clinical Biochemistry and Pharmacology (L.M.R.), Odense University Hospital, Denmark; and Cardiovascular Research Unit, Region Hospital Viborg, Denmark (M.D., J.S.L.).
    Objective: An inverse association between abdominal aortic aneurysms (AAAs) and diabetes mellitus exists; however, the cause remains unknown. This study aimed to evaluate whether the degree of glycemia is associated with aneurysm growth.

    Approach And Results: The study was based on VIVA trial (Viborg Vascular), the randomized clinically controlled screening trial for abdominal aortic aneurysm in men aged 65 to 74 years in the Central Denmark Region. Read More

    The Frozen Elephant Trunk Technique: European Association for Cardio-Thoracic Surgery Position and Bologna Experience.
    Korean J Thorac Cardiovasc Surg 2017 Feb 5;50(1):1-7. Epub 2017 Feb 5.
    Department of Cardiac Surgery, Sant'Orsola Hospital, Bologna University.
    Complex lesions of the thoracic aorta are traditionally treated in 2 surgical steps with the elephant trunk technique. A relatively new approach is the frozen elephant trunk (FET) technique, which potentially allows combined lesions of the thoracic aorta to be treated in a 1-stage procedure combining endovascular treatment with conventional surgery using a hybrid prosthesis. These are very complex and time-consuming operations, and good results can be obtained only if appropriate strategies for myocardial, cerebral, and visceral protection are adopted. Read More

    [Thoracic Endovascular Aortic Repair for a Descending Thoracic Aneurysm Associated with Pseudocoarctation of the Aorta;Report of a Case].
    Kyobu Geka 2017 Feb;70(2):123-126
    Department of Cardiovascular Surgery, Hiraka General Hospital, Yokote, Japan.
    A 77-year-old man with a descending thoracic aneurysm associated with pseudocoarctation of the aorta underwent thoracic endovascular aortic repair (TEVAR). Computed tomography demonstrated kinking of the descending thoracic aorta. The aneurysm was located distal to a kinking and constricting aortic isthmus. Read More

    Glutathione system participation in thoracic aneurysms from patients with Marfan syndrome.
    Vasa 2017 Feb 8:1-10. Epub 2017 Feb 8.
    1 Departaments of Immunology, Instituto Nacional de Cardiología "Ignacio Chávez", México City, México.
    Background: Aortic dilatation in Marfan syndrome (MFS) is progressive. It is associated with oxidative stress and endothelial dysfunction that contribute to the early acute dissection of the vessel and can result in rupture of the aorta and sudden death. We evaluated the participation of the glutathione (GSH) system, which could be involved in the mechanisms that promote the formation and progression of the aortic aneurysms in MFS patients. Read More

    Two decades of experience with root remodeling and valve repair for bicuspid aortic valves.
    J Thorac Cardiovasc Surg 2017 Jan 10. Epub 2017 Jan 10.
    Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg/Saar, Germany. Electronic address:
    Objective: Bicuspid aortic valve anatomy is associated with ascending aortic aneurysm in approximately 50% of individuals and may lead to severe aortic regurgitation with aortic dilatation. Both entities may be treated by valve repair and root remodeling. The objective was to review the cumulative experience of 20 years. Read More

    Technical Aspects of Implanting the t-Branch Off-the-Shelf Multibranched Stent-Graft for Thoracoabdominal Aneurysms.
    J Endovasc Ther 2017 Feb 1:1526602817690730. Epub 2017 Feb 1.
    1 Department of Vascular Medicine, German Aortic Center, Hamburg, Germany.
    Purpose: To describe the planning and technique for implantation of the t-Branch off-the-shelf multibranched aortic endograft.

    Technique: Total endovascular repair of thoracoabdominal aneurysms (TAAAs) with branched endografts is one of the most important paradigm shifts in the past decade. The t-Branch endograft, an off-the-shelf multibranched graft introduced in the European market in late 2012, allows treatment of patients with suitable anatomy in both the elective and urgent settings to avoid delays related to manufacturing time of custom-made devices. Read More

    Novel Pathogenic Variant in TGFBR2 Confirmed by Molecular Modeling Is a Rare Cause of Loeys-Dietz Syndrome.
    Case Rep Genet 2017 9;2017:7263780. Epub 2017 Jan 9.
    Department of Clinical Genomics, Center for Individualized Medicine, Mayo Clinic, Jacksonville, FL, USA; Division of Medical Genetics, Department of Pediatrics, Stanford University, Stanford, CA, USA.
    Loeys-Dietz syndrome (LDS) is a connective tissue disorder characterized by vascular findings of aneurysm and/or dissection of cerebral, thoracic, or abdominal arteries and skeletal findings. We report a case of a novel pathogenic variant in TGFBR2 and phenotype consistent with classic LDS. The proband was a 10-year-old presenting to the genetics clinic with an enlarged aortic root (Z-scores 5-6), pectus excavatum, and congenital contractures of the right 2nd and 3rd digit. Read More

    Treatment of an aortic arch aneurysm with scalloped and fenestrated thoracic stent-graft and left carotid to subclavian artery bypass.
    Ann Vasc Surg 2017 Feb 2. Epub 2017 Feb 2.
    Department of Vascular Surgery, Singapore General Hospital. Electronic address:
    We report a successful treatment of thoracic arch aneurysm using a combination of hybrid approach and a customized stent graft in a frail patient with challenging anatomy and concomitant large retrosternal goiter. The patient is an 82-year-old lady with multiple comorbidities who presented to her general practitioner for anorexia and significant weight loss. She was incidentally found to have a 6. Read More

    Cysts of the Iris Pigment Epithelium. What Is New and Interesting? The 2016 Jose Rizal International Medal Lecture.
    Asia Pac J Ophthalmol (Phila) 2017 Jan-Feb;6(1):64-69
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA.
    Purpose: Cysts of the iris pigment epithelium (IPE) can involve the pupillary margin, midzone, or peripheral location or can be free-floating in the aqueous or vitreous or lodged in the anterior chamber angle. Avariant of IPE cyst, known as iris flocculi, can be a marker for systemic thoracic aneurysm.

    Design: Review of IPE cysts and description of new observations of the lesions. Read More

    Surgical Indication for Chronic Aortic Dissection in Descending Thoracic and Thoracoabdominal Aorta.
    Circ Cardiovasc Interv 2017 Feb;10(2)
    From the Department of Cardiovascular Surgery (T.O., K.M., H.S., H.T., Y.S., T.I., Y.I., J.K.), Department of Radiology (M.H.), and Department of Preventive Medicine and Epidemiology (K.N.), National Cerebral and Cardiovascular Center, Osaka, Japan.
    Background: To address the lack of information about the size of ruptures associated with chronic dissection in the descending and thoracoabdominal aorta, we evaluated the natural history of this pathology.

    Methods And Results: We analyzed data from 571 patients (mean age, 69.4±11. Read More

    Thoracic Aortic Aneurysm Growth: Role of Sex and Aneurysm Etiology.
    J Am Heart Assoc 2017 Feb 3;6(2). Epub 2017 Feb 3.
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Background: Thoracic aortic aneurysm (TAA) outcomes are worse in women than men, although reasons for sex differences are unknown. Because faster TAA growth is a risk factor for acute aortic syndromes, we sought to determine the role of sex and aneurysm etiology on TAA growth.

    Methods And Results: Eighty-two consecutive unoperated subjects with TAA who had serial aneurysm measurements were recruited. Read More

    IgG4-positive cell infiltration in various cardiovascular disorders - results from histopathological analysis of surgical samples.
    BMC Cardiovasc Disord 2017 Feb 3;17(1):52. Epub 2017 Feb 3.
    Department of Cardiology, Osaka Medical College, Daigaku-machi 2-7, Takatsuki, Osaka, 569-8686, Japan.
    Background: The diagnosis of Immunoglobulin G4 (IgG4)-related disease (IgG4-RD), in general, depends on serum IgG4 concentrations and histopathological findings; therefore, diagnosis of IgG4-RD in cardiovascular organs/tissues is often difficult owing to the risk of tissue sampling.

    Methods: Prevalence of IgG4-positive lymphoplasmacytic infiltration in 103 consecutive cardiovascular surgical samples from 98 patients with various cardiovascular diseases was analyzed immunohistochemically.

    Results: The diagnoses of the enrolled patients included aortic aneurysm (abdominal, n = 8; thoracic, n = 9); aortic dissection (n = 20); aortic stenosis (n = 24), aortic regurgitation (n = 10), and mitral stenosis/regurgitation (n = 17). Read More

    Fibromuscular dysplasia - results of a multicentre study in Flanders.
    Vasa 2017 Feb 3:1-8. Epub 2017 Feb 3.
    9 Department of Cardiac and Vascular Diseases, Ghent University Hospital, UZ Ghent, Ghent, Belgium.
    Background: Fibromuscular dysplasia (FMD) is an idiopathic, non-inflammatory, non-atherosclerotic vascular disease, resulting in focal narrowing of small and medium-sized arteries. Systematic recording of clinical data in central databases as in the US and France provided new insights into FMD. The main objectives of this multicentre study were to explore the epidemiology, pattern of vascular involvement, clinical manifestations, and management of FMD patients in Flanders. Read More

    Systemic Inflammatory Response and Severe Thrombocytopenia after Endovascular Thoracic Aortic Aneurysm Repair.
    Case Rep Med 2017 5;2017:3018919. Epub 2017 Jan 5.
    Department of Medicine-DIMED, Clinica Medica 3, University Hospital of Padova, Padova, Italy.
    After Endovascular repair of thoracic aortic aneurysm, a systemic inflammatory response, named postimplantation syndrome, can develop. This syndrome is characterized by fever, leukocytosis, and elevated CRP plasma levels and its pathogenetic mechanisms are still unknown. Although this syndrome generally resolves within few days, some patients develop a persisting severe inflammatory reaction leading to mild or severe complications. Read More

    NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.
    Arterioscler Thromb Vasc Biol 2017 Feb 2. Epub 2017 Feb 2.
    From the Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery (D.W., P. R., Y.Z., L.Z., G.X., W.X., J.S.C., Q.Z., Y.H.S., S.A.L.), Cardiovascular Research Institute (J.S.C., Y.H.S., S.A.L.), and Department of Molecular Physiology and Biophysics (D.W., E.E.L., S.A.L.), Baylor College of Medicine, Houston, TX; Department of Cardiovascular Surgery, Texas Heart Institute, Houston (D.W., G.X., L.Z., W.X., J.S.C., S.A.L.); Cardiology MD Anderson Cancer Center, Houston, Texas (S.Z.); Division of Vascular Surgery, Vanderbilt University School of Medicine, Nashville, TN (J.A.C.); and Division of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston (D.M.M).
    Objective: Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and aortic aneurysm and dissection (AAD) development. However, the mechanisms underlying SMC contractile dysfunction in sporadic AAD are poorly understood. In this study, we examined the role of the NLRP3 (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3)-caspase-1 inflammasome, a key inflammatory cascade, in SMC contractile dysfunction in AAD. Read More

    Esophageal transection.
    Ulus Cerrahi Derg 2016 1;32(4):281-284. Epub 2016 Dec 1.
    Department of General Surgery, Istanbul University Istanbul School of Medicine, Istanbul, Turkey.
    Herein, a case of intramural esophageal dissection is reported and the literature is reviewed. Intramural esophageal dissection is a rare but well described condition that is characterized by a laceration between the esophageal mucosa and submucosa but without perforation. A female patient aged 86 years was hospitalized with a diagnosis of abdominal aortic aneurysm. Read More

    Supraclavicular transposition of aberrant left vertebral artery for hybrid treatment of aortic arch aneurysm: a case report.
    J Cardiothorac Surg 2017 Jan 31;12(1). Epub 2017 Jan 31.
    Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital, Chonnam National University School of Medicine, 42, Jebong-ro, Dong-gu, Gwangju, 15772, South Korea.
    Background: Vertebral artery variations are common in thoracic aortic patients. If patients have the aberrant left vertebral artery, the more difficult to determine the treatment modality.

    Case Presentation: We report the case of a 63-year-old man with an aberrant left vertebral artery originating from an aneurysmal aortic arch. Read More

    Modelling of aortic aneurysm and aortic dissection through 3D printing.
    J Med Radiat Sci 2017 Jan 30. Epub 2017 Jan 30.
    Department of Medical Radiation Sciences, Curtin University, Perth, Western Australia, Australia.
    Introduction: The aim of this study was to assess if the complex anatomy of aortic aneurysm and aortic dissection can be accurately reproduced from a contrast-enhanced computed tomography (CT) scan into a three-dimensional (3D) printed model.

    Methods: Contrast-enhanced cardiac CT scans from two patients were post-processed and produced as 3D printed thoracic aorta models of aortic aneurysm and aortic dissection. The transverse diameter was measured at five anatomical landmarks for both models, compared across three stages: the original contrast-enhanced CT images, the stereolithography (STL) format computerised model prepared for 3D printing and the contrast-enhanced CT of the 3D printed model. Read More

    Computerized tomography angiography by direct intra-aortic low volume contrast injection in patients being evaluated for EVAR.
    Vascular 2017 Jan 1:1708538117690662. Epub 2017 Jan 1.
    4 Division of Vascular Surgery and Endovascular Therapy, University of Southern California, Los Angeles, CA, USA.
    Background Computerized tomography angiography is an important tool for endovascular repair of abdominal aortic aneurysm planning. This study aimed to evaluate the utility of computerized tomography angiography using direct intra-aortic injection of low volume of iodinated contrast in patients being considered for endovascular repair of abdominal aortic aneurysm. Design A 5F high-flow angiographic catheter was positioned in the mid-thoracic aorta through femoral percutaneous access. Read More

    A Multicentre Trial of Patient specific Rehearsal Prior to EVAR: Impact on Procedural Planning and Team Performance.
    Eur J Vasc Endovasc Surg 2017 Jan 20. Epub 2017 Jan 20.
    Department of Thoracic and Vascular Surgery, Ghent University Hospital, Ghent, Belgium.
    Objective: Patient specific rehearsal (PsR) prior to endovascular aneurysm repair (EVAR) enables the endovascular team to practice and evaluate the procedure prior to treating the real patient. This multicentre trial aimed to evaluate the utility of PsR prior to EVAR as a pre-operative planning and briefing tool.

    Material And Methods: Patients with an aneurysm suitable for EVAR were randomised to pre-operative or post-operative PsR. Read More

    Genetic and Epigenetic Regulation of Aortic Aneurysms.
    Biomed Res Int 2017 1;2017:7268521. Epub 2017 Jan 1.
    Vascular Biology Center, Augusta University, Augusta, GA, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA, USA.
    Aneurysms are characterized by structural deterioration of the vascular wall leading to progressive dilatation and, potentially, rupture of the aorta. While aortic aneurysms often remain clinically silent, the morbidity and mortality associated with aneurysm expansion and rupture are considerable. Over 13,000 deaths annually in the United States are attributable to aortic aneurysm rupture with less than 1 in 3 persons with aortic aneurysm rupture surviving to surgical intervention. Read More

    Severe Rhabdomyolysis as Complication of Interaction between Atorvastatin and Fusidic Acid in a Patient in Lifelong Antibiotic Prophylaxis: A Dangerous Combination.
    Case Rep Med 2016 27;2016:4705492. Epub 2016 Dec 27.
    Medical Department, Infectious Diseases Division, National Hospital Faroe Islands, Tórshavn, Faroe Islands; Infectious Diseases Research Unit, Odense University Hospital and University of Southern Denmark, Odense, Denmark; Faculty of Science and Technology, University of the Faroe Islands, Tórshavn, Faroe Islands.
    Atorvastatin and HMG-CoA reductase inhibitors are the most frequently used medication in the world due to very few adverse toxic side effects. One potentially life threatening adverse effect is caused by clinically significant statin induced rhabdomyolysis, either independently or in combination with fusidic acid. The patient in our case who previously had cardiac insufficiency, atrial fibrillation, and thoracic aorta aneurysm and was treated with insertion of an endovascular metallic stent in the aorta is presented in the report. Read More

    Acute aorta, overview of acute CT findings and endovascular treatment options.
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2017 Jan 2. Epub 2017 Jan 2.
    Institute of Diagnostic and Interventional Radiology, Klinikum Oldenburg, Oldenburg, Germany.
    Acute aortic pathologies include acute aortic syndrome (aortic dissection, intramural hematoma, penetrating aortic ulcer), impending rupture, aortic aneurysm rupture and aortic trauma. Acute aortic syndrome, aortic aneurysm rupture and aortic trauma are life-threatening conditions requiring prompt diagnosis and treatment. The basic imaging modality for "acute aorta" is CT angiography with typical findings for these aortic pathologies. Read More

    Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.
    Circ Res 2017 Jan 23. Epub 2017 Jan 23.
    Biochemistry and Molecular Biology, Hebei Medical University
    Rationale: Abdominal aortic aneurysms (AAAs) are characterized by pathological remodeling of the aortic wall. Although both increased Krüppel-like factor 5 (KLF5) expression and macrophage infiltration have been implicated in vascular remodeling, the role of KLF5 in macrophage infiltration and AAA formation remains unclear.

    Objective: To determine the role of KLF5 in AAA formation and macrophage infiltration into AAAs. Read More

    Reversed Frozen Elephant Trunk Technique to Treat a Type II Thoracoabdominal Aortic Aneurysm.
    J Endovasc Ther 2016 Nov 1:1526602816678992. Epub 2016 Nov 1.
    1 German Aortic Center Hamburg, Department of Vascular Medicine, University Heart Center, Hamburg, Germany.
    Purpose: To describe a hybrid technique of reversed frozen elephant trunk to treat thoracoabdominal aortic aneurysms (TAAA) through an abdominal only approach.

    Technique: The technique is demonstrated in a 29-year-old Marfan patient with a chronic type B aortic dissection previously treated with a thoracic stent-graft who presented with a thoracoabdominal false lumen aneurysm. Through an open distal retroperitoneal approach to the abdominal aorta, a frozen elephant trunk graft was implanted over a super-stiff wire upside down with the stent-graft component in the thoracic aorta. Read More

    Trends in Patient Safety of Intact Abdominal Aortic Aneurysm Repair: German Registry Data on 36,594 Procedures.
    Eur J Vasc Endovasc Surg 2017 Jan 19. Epub 2017 Jan 19.
    Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address:
    Objective/background: The study aim was to determine whether patient safety for non-ruptured abdominal aortic aneurysm (nrAAA) repair has changed between 1999 and 2010 in a large German cohort.

    Methods: The data source was the prospective quality assurance registry of the German Vascular Society from 1999 to 2010. Patient characteristics, surgical techniques (open aortic repair [OAR], endovascular aortic repair [EVAR]), procedural time and outcomes, including the length of hospital stay (LOS), were analysed using the Cochran-Armitage test for binary parameters and Spearman's correlation coefficient for quantitative parameters. Read More

    Endovascular Technique for Repair of Descending Thoracic Aortic Aneurysm After Coarctation Operation.
    Ann Thorac Surg 2017 Feb;103(2):e167-e169
    The Heart Hospital Baylor Plano, Plano, Texas. Electronic address:
    The incidence of aneurysm after open surgical repair of coarctation is 11% to 24%. If the condition is left untreated, fatal rupture may occur. Thoracic endovascular aortic repair (TEVAR) has been reported as a feasible and safe alternative to open surgical repeated procedures in this context. Read More

    Antineutrophil Cytoplasmic Antibody-Associated Multiple Giant Saccular Aortic Aneurysms.
    Ann Thorac Surg 2017 Feb;103(2):e153-e155
    Department of Cardiovascular Surgery, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
    We describe a very rare case of a 67-year-old man with multiple saccular aortic aneurysms throughout the entire aorta due to antineutrophil cytoplasmic antibody-associated vasculitis (AAV). The patient underwent staged aortic surgical procedures, including stent-graft insertion for a left iliac artery aneurysm, thoracic endovascular aortic repair for a descending aortic aneurysm, and total replacement of the ascending aorta and aortic arch with the use of high-dose steroids to control inflammation. The histologic findings demonstrated that the damage to the vasa vasorum of the adventitia resulting from AAV caused ischemia of the media, resulting in the formation of saccular aneurysmal changes. Read More

    Pericardial fat flap: surgical technique for infection control after graft replacement.
    Multimed Man Cardiothorac Surg 2017 Jan 18;2017. Epub 2017 Jan 18.
    Surgical treatment of mycotic aneurysm of the thoracic aorta is challenging because contamination from surrounding tissues may occur even after complete debridement with a prosthetic graft replacement of the aneurysm. This study describes the simple but very useful technique of using a pericardial fat flap to protect the prosthetic graft from reinfection. Read More

    Impact of Thoracic Endovascular Aortic Repair on Pulsatile Circumferential and Longitudinal Strain in Patients With Aneurysm.
    J Endovasc Ther 2017 Jan 1:1526602816687086. Epub 2017 Jan 1.
    1 Thoracic Aortic Research Center, Policlinico San Donato IRCCS, University of Milan, Italy.
    Purpose: To quantify both pulsatile longitudinal and circumferential aortic strains before and after thoracic endovascular aortic repair (TEVAR), potentially clarifying TEVAR-related complications.

    Methods: This retrospective study assessed the impact of TEVAR on pulsatile aortic strains through custom developed software and cardiac-gated computed tomography imaging of 8 thoracic aneurysm patients (mean age 71.0±8. Read More

    Total Arch versus Hemiarch Replacement for Type A Acute Aortic Dissection: A Single-Center Experience.
    Tex Heart Inst J 2016 Dec 1;43(6):488-495. Epub 2016 Dec 1.
    We retrospectively evaluated early and intermediate outcomes of aortic arch surgery in patients with type A acute aortic dissection (AAD), investigating the effect of arch surgery extension on postoperative results. From January 2006 through July 2013, 201 patients with type A AAD underwent urgent corrective surgery at our institution. Of the 92 patients chosen for this study, 59 underwent hemiarch replacement (hemiarch group), and 33 underwent total arch replacement (total arch group) in conjunction with ascending aorta replacement. Read More

    Management of Type II Endoleak From Internal Iliac Artery Immediately After Endovascular Aneurysm Repair.
    Vasc Endovascular Surg 2017 Jan;51(1):47-50
    1 Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
    Inadvertent coverage of origin of internal iliac artery (IIA) during endovascular aneurysm repair may lead to type II endoleak. Except for open surgery, the endovascular solution is limited. We report a case with such complication that was successfully treated with coil embolization using retrograde extrastent approach. Read More

    KIF6 719Arg Genetic Variant and Risk for Thoracic Aortic Dissection.
    Aorta (Stamford) 2016 Jun 1;4(3):83-90. Epub 2016 Jun 1.
    Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut, USA.
    Background: Carriers of the 719Arg variant in KIF6, compared with noncarriers, have been reported to be at greater risk for coronary heart disease (CHD) in six prospective studies. Because CHD, thoracic aortic dissection, and nondissection thoracic aortic aneurysm share some risk factors and aspects of pathophysiology, we investigated whether carriers of the 719Arg variant also have greater odds of thoracic aortic dissection or nondissected thoracic aortic aneurysm than noncarriers.

    Methods: We genotyped 140 thoracic aortic dissection cases, 497 nondissection thoracic aortic aneurysm cases, and 275 disease-free controls collected in the United States, Hungary, and Greece and investigated the association between KIF6 719Arg carrier status and thoracic aortic dissection, and between KIF6 719Arg carrier status and nondissection thoracic aortic aneurysm, using logistic regression models adjusted for age, sex, hypertension, smoking, and country. Read More

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