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    Upregulation of MicroRNA-15a Contributes to Pathogenesis of Abdominal Aortic Aneurysm (AAA) by Modulating the Expression of Cyclin-Dependent Kinase Inhibitor 2B (CDKN2B).
    Med Sci Monit 2017 Feb 18;23:881-888. Epub 2017 Feb 18.
    Department of Cardiac Surgery, No. 1 People's Hospital of Jining, Jining, Shandong, China (mainland).
    BACKGROUND The objective of the present study was to identify the association between miR-15a-5p and CDKN2B, and their roles in regulating the development of abdominal aortic aneurysm (AAA). MATERIAL AND METHODS We searched the miRNA database online (www.mirdb. Read More

    Inhibition of the mTOR pathway in abdominal aortic aneurysm: implication of smooth muscle cell contractile phenotype, inflammation and aneurysm expansion.
    Am J Physiol Heart Circ Physiol 2017 Feb 17:ajpheart.00677.2016. Epub 2017 Feb 17.
    the First Hospital of China Medical University
    The development of effective pharmacological treatment of abdominal aortic aneurysm (AAA) potentially offers great benefit to patients with pre-aneurysmal aortic dilation by slowing the expansion of aneurysms and reducing the need for surgery. To date, therapeutic targets for slowing aortic dilation have had low efficacy. Thus, in this study, we aim to elucidate possible mechanisms driving aneurysm progression in order to identify potential targets for pharmacological intervention. Read More

    A mathematical model of aortic aneurysm formation.
    PLoS One 2017 17;12(2):e0170807. Epub 2017 Feb 17.
    Yunnan Cocreative Scientific Computing and Datamining Center, Kunming, China.
    Abdominal aortic aneurysm (AAA) is a localized enlargement of the abdominal aorta, such that the diameter exceeds 3 cm. The natural history of AAA is progressive growth leading to rupture, an event that carries up to 90% risk of mortality. Hence there is a need to predict the growth of the diameter of the aorta based on the diameter of a patient's aneurysm at initial screening and aided by non-invasive biomarkers. Read More

    Association of Matrix Metalloproteinase Levels with Collagen Degradation in the Context of Abdominal Aortic Aneurysm.
    Eur J Vasc Endovasc Surg 2017 Feb 10. Epub 2017 Feb 10.
    Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. Electronic address:
    Objective/background: Matrix metalloproteinases (MMPs) have already been identified as key players in the pathogenesis of abdominal aortic aneurysm (AAA). However, the current data remain inconclusive. In this study, the expression of MMPs at mRNA and protein levels were investigated in relation to the degradation of collagen I and collagen III. Read More

    Endovascular repair of bilateral common iliac artery aneurysms using GORE Excluder iliac branch endoprosthesis without aortobi-iliac stent graft conjunction: A case report.
    Medicine (Baltimore) 2017 Feb;96(7):e5977
    aVascular Surgery and Organ Transplant Unit, University Hospital of Catania, Via Santa Sofia, Catania bVascular Surgery Unit, Guzzardi Hospital of Vittoria, Via Papa Giovanni XXIII, Vittoria cDepartment of Medical and Surgical Sciences and Advanced Technologies, University Hospital of Catania, Via Santa Sofia, Catania dDepartment of Surgical Specialties, University Hospital of Catania, Via Santa Sofia, Catania, Italy.
    Introduction: Bilateral common iliac artery (CIA) aneurysm (CIAA) is a rare entity. In the past decade, different endovascular approaches have been adopted for patients with several comorbidities or unfit for open repair (OR). Recently, the use of iliac branch stent graft has been proposed, resulting in satisfactory patency rates and decrease in morbidity. Read More

    Graft Complexity-Related Outcomes of Fenestrated Endografting for Abdominal Aortic Aneurysms.
    J Endovasc Ther 2017 Feb 1:1526602817691752. Epub 2017 Feb 1.
    1 Department of Vascular Surgery, University Medical Center Regensburg, Germany.
    Purpose: To report the outcomes of fenestrated endovascular aneurysm repair (FEVAR) and compare early and midterm results in relation to stent-graft complexity.

    Methods: Between August 2006 and December 2014, 141 consecutive patients (mean age 72±7.6 years, range 50-89; 120 men) were treated electively with FEVAR for short-neck, juxtarenal, or suprarenal aortic aneurysms. Read More

    Push-Up Technique and Anatomical Deployment With the Endurant Stent-Graft System for Severely Angulated Aneurysm Necks.
    J Endovasc Ther 2017 Feb 1:1526602817692790. Epub 2017 Feb 1.
    1 Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo, Japan.
    Purpose: To describe a technique suitable for treating severely angulated (>75°) necks during endovascular aneurysm repair using the Endurant stent-graft.

    Technique: In the push-up technique, the suprarenal stent is released early to fix the proximal stent-graft in place so that each stent in the neck can be deployed individually without displacing the device upward. It is important to push the delivery system up after each stent deployment to allow the fabric between the stents to fold up circumferentially. Read More

    Deletion of Hypoxia-Inducible Factor-1α in Myeloid Lineage Exaggerates Angiotensin II-Induced Formation of Abdominal Aortic Aneurysm.
    Clin Sci (Lond) 2017 Feb 14. Epub 2017 Feb 14.
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
    Hypoxia-inducible factor (HIF)-1α is a transcription factor that regulates various genes responding to hypoxic conditions. We previously reported that myeloid-specific activation of HIF-1α had protective effects on hypertensive cardiovascular remodeling in mice. However the role of myeloid lineage HIF-1α in the development of abdominal aortic aneurysm (AAA) has not been determined. Read More

    Safety and efficacy of embolization using Onyx(®) of persistent type II endoleaks after abdominal endovascular aneurysm repair.
    Diagn Interv Imaging 2017 Feb 10. Epub 2017 Feb 10.
    Department of radiology, hôpital Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux, France.
    Purpose: To retrospectively evaluate the safety and efficacy of embolization of persistent type II endoleaks occurring after abdominal endovascular aneurysm repair (EVAR) using ethylene vinyl alcohol copolymer (Onyx(®)).

    Material And Methods: Between 2008 and 2016, 28 consecutives patients (25 men, 3 women) with a mean age of 75.3years±9 (SD) (range: 59-90years) were treated for 29 persistent type II endoleaks with increasing aneurysm size>5mm occurring after EVAR. Read More

    Spatial differences of matrix metalloproteinase-2 and matrix metalloproteinase-9 within abdominal aortic aneurysm wall and intraluminal thrombus.
    J Physiol Pharmacol 2016 Dec;67(6):903-910
    Department of Laboratory Diagnostics, Pomeranian Medical University, Szczecin, Poland.
    Formation of an abdominal aortic aneurysm is a complex process involving aortic wall degradation. The matrix metalloproteinases (MMPs) mainly involved in this process are MMP-2 and MMP-9. Most aneurysms contain an intraluminal thrombus. Read More

    Treatment of Type II Endoleaks with a Novel Agent: Precipitating Hydrophobic Injectable Liquid (PHIL).
    Cardiovasc Intervent Radiol 2017 Feb 13. Epub 2017 Feb 13.
    Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ, England, UK.
    Objective: Endovascular aortic aneurysm repair has become the principle technique used to treat abdominal aortic aneurysms. However, its long-term success is limited by complications, including type II endoleaks from lumbar arteries and the inferior mesenteric artery. Treatment of these endoleaks can be difficult. Read More

    Improving the results of transarterial embolization of type 2 endoleaks with the embolic polymer Onyx.
    Wideochir Inne Tech Maloinwazyjne 2016 20;11(4):259-267. Epub 2016 Dec 20.
    2 Department of Clinical Radiology, Medical University of Warsaw, Warsaw, Poland.
    Introduction: Type 2 endoleaks (T2E) occur in 10 to 20% of patients after endovascular abdominal aortic aneurysm repair (EVAR) and remain a significant clinical issue.

    Aim: To evaluate the efficacy and clinical outcomes of transarterial treatment of persistent type II endoleaks after EVAR using the liquid embolic Onyx.

    Material And Methods: From February 2012 to August 2015 transarterial T2E embolization was attempted in 22 patients (21 men, median age: 73, range: 62-88 years). Read More

    Abdominal ultrasound-scanning versus non-contrast computed tomography as screening method for abdominal aortic aneurysm - a validation study from the randomized DANCAVAS study.
    BMC Med Imaging 2017 Feb 14;17(1):14. Epub 2017 Feb 14.
    Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Cardiovascular Centre of Excellence (CAVAC), Sdr. Boulevard 29, Afd. T - Forskerreden, 5000, Odense C, Denmark.
    Background: Validating non-contrast-enhanced computed tomography (nCT) compared to ultrasound sonography (US) as screening method for abdominal aortic aneurysm (AAA) screening.

    Methods: Consecutively attending men (n = 566) from the pilot study of the randomized Danish CardioVascular Screening trial (DANCAVAS trial), underwent nCT and US examination. Diameters were measured in outer-to-outer fashion. Read More

    Abdominal Aortic Aneurysm Screening Reduces All-Cause Mortality.
    Angiology 2017 Jan 1:3319717693107. Epub 2017 Jan 1.
    1 Department of Cardiovascular Surgery, Shizuoka Medical Center, Shizuoka, Japan.
    We performed an updated meta-analysis of the longest (≥13 years) follow-up results from 4 randomized controlled trials of abdominal aortic aneurysm (AAA) screening in ≥64-year-old men. Invitation to screening reduced all-cause mortality significantly according to time-to-event data (hazard ratio: 0.98; 95% confidence interval [CI]: 0. Read More

    Lombard Aorfix high angulation device, sac behavior following implantation.
    J Vasc Surg 2017 Feb 9. Epub 2017 Feb 9.
    Department of Surgery, Brigham and Women's Hospital, Boston, Mass.
    Objective: Short neck length, and angulated infrarenal aortic necks, are historically associated with sac expansion following endovascular abdominal aortic aneurysm repair. Aorfix (Lombard Medical, Inc, Irvine, Calif), a conformable stent graft US Food and Drug Administration approved for highly angulated necks, was investigated in the US Pythagoras Trial. We investigated the incidence of, and factors related to, sac regression and expansion following implantation of the Aorfix device. Read More

    Transient atrial fibrillation after open abdominal aortic revascularization surgery is associated with increased length of stay, mortality, and readmission rates.
    J Vasc Surg 2017 Feb 9. Epub 2017 Feb 9.
    Department of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Ill; One:MAP Section of Surgical Analytics, Department of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Ill. Electronic address:
    Background: It is well established that transient postoperative atrial fibrillation (TPAF) is associated with adverse postoperative outcomes after major cardiac and noncardiac operations. The purpose of this study was to elucidate the incidence, impact, and risk factors associated with the development of TPAF in patients undergoing revascularization surgery for occlusive diseases of the abdominal aorta and its branches (AAB).

    Methods: By use of the Healthcare Cost and Utilization Project State Inpatient Database from Florida and California, patients who underwent open revascularization of AAB between 2006 and 2011 were identified. Read More

    Effect of antiplatelet therapy on aneurysmal sac expansion associated with type II endoleaks after endovascular aneurysm repair.
    J Vasc Surg 2017 Feb 9. Epub 2017 Feb 9.
    Vascular Surgery Department, A Coruña University Healthcare Complex (CHUAC), A Coruña, Spain.
    Objective: Endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAAs) has gained widespread use through a solid reputation of safety and effectiveness. However, some issues, such as endoleaks and sac growth over time, still arise as important concerns. Antiplatelet therapy, mandatory as secondary prevention of cardiovascular disease, may play a role in both phenomena by interfering with blood clotting properties and the inflammatory process associated with AAA. Read More

    [Clinical analysis of 24 cases of aortic dissection during pregnancy].
    Zhonghua Fu Chan Ke Za Zhi 2017 Jan;52(1):32-39
    Department of Obstetrics and Gynecology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China.
    Objective: To investigate the management and perinatal outcome of aortic dissection during pregnancy. Methods: 24 pregnant women with aortic dissection who delivered in Beijing Anzhen Hospital Affiliated to Capital Medical University from January 1st, 2006 to February 29th, 2016 were recruited. The clinical data, the management and the perinatal outcome were analyzed retrospectively. Read More

    Comparison of outcomes for double fenestrated endovascular aneurysm repair versus triple or quadruple fenestrated endovascular aneurysm repair in the treatment of complex abdominal aortic aneurysms.
    J Vasc Surg 2017 Feb 8. Epub 2017 Feb 8.
    Department of Vascular and Endovascular Surgery, Paracelsus Medical University, Nuremberg, Germany.
    Objective: This study compared outcomes of standard fenestrated endovascular aneurysm repair (St-FEVAR) with renal artery fenestrations only with more complex FEVAR (Co-FEVAR) with additional fenestrations for the superior mesenteric artery or the celiac trunk, or both.

    Methods: All consecutive patients treated with FEVAR for short-necked, juxtarenal, or suprarenal aortic aneurysms between January 2010 and July 2016 were included. Patients with stent grafts with a combination of fenestrations and branches were excluded. Read More

    Natural history of gutter-related type Ia endoleaks after snorkel/chimney endovascular aneurysm repair.
    J Vasc Surg 2017 Feb 8. Epub 2017 Feb 8.
    Division of Vascular Surgery, Stanford University Medical Center, Stanford, Calif. Electronic address:
    Objective: Alternative endovascular strategies using parallel or snorkel/chimney (chimney endovascular aneurysm repair [ch-EVAR]) techniques have been developed to address the lack of widespread availability and manufacturing limitations with branched/fenestrated aortic devices for the treatment of complex abdominal aortic aneurysms. Despite high technical success and midterm patency of snorkel stent configurations, concerns remain regarding the perceived increased incidence of early gutter-related type Ia endoleaks. We aimed to evaluate the incidence and natural history of gutter-related type Ia endoleaks following ch-EVAR. Read More

    Abdominal aortic aneurysm-an independent disease to atherosclerosis?
    Cardiovasc Pathol 2017 Jan 29;27:71-75. Epub 2017 Jan 29.
    Department of Cardiovascular Sciences and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, UK.
    Atherosclerosis and abdominal aortic aneurysms (AAAs) are multifactorial and polygenic diseases with known environmental and genetic risk factors that contribute toward disease development. Atherosclerosis represents an important independent risk factor for AAA, as people with AAA often have atherosclerosis. Studies have shown that comorbidity is usually between ~25% and 55%, but it is still not fully known whether this association is causal or a result of common shared risk profiles. Read More

    What are the decision-making preferences of patients in vascular surgery? A mixed-methods study.
    BMJ Open 2017 Feb 10;7(2):e013272. Epub 2017 Feb 10.
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
    Objectives: Shared decision-making (SDM) has been advocated as the preferred method of choosing a suitable treatment option. However, patient involvement in treatment decision-making is not yet common practice in the field of vascular surgery. The aim of this mixed-methods study was to explore patients' decision-making preferences and to investigate which facilitators and barriers patients perceive as important for the application of SDM in vascular surgery. Read More

    Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice.
    IEEE Trans Med Imaging 2017 Feb 6. Epub 2017 Feb 6.
    A multi-modality imaging based modeling approach was used to study complex unsteady hemodynamics and lesion growth in a dissecting abdominal aortic aneurysm model. We combined in vivo ultrasound (geometry and flow) and in vitro optical coherence tomography (geometry) to obtain the high resolution needed to construct detailed hemodynamic simulations over large portions of the murine vasculature, which include fine geometric complexities. We illustrate this approach for a spectrum of dissecting abdominal aortic aneurysms induced in male apolipoprotein E-null mice by high-dose angiotensin II infusion. Read More

    Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin-1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model.
    Sci Rep 2017 Feb 10;7:42159. Epub 2017 Feb 10.
    Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
    Abdominal aortic aneurysm (AAA) is a common aortic disease with a progressive nature. There is no approved pharmacological treatment to effectively slow aneurysm growth or prevent rupture. Necroptosis is a form of programmed necrosis that is regulated by receptor-interacting protein kinases (RIPs). Read More

    A novel SMAD3 mutation caused multiple aneurysms in a patient without osteoarthritis symptoms.
    Eur J Med Genet 2017 Feb 7. Epub 2017 Feb 7.
    Surgical Research Center, GIGA-R, Belgium; Department of Cardiovascular and Thoracic Surgery, University Hospital of Liège, Belgium.
    Heterozygous mutations in the SMAD3 gene were recently described as the cause of a form of non-syndromic familial aortic thoracic aneurysm and dissection (FTAAD) transmitted as an autosomal dominant disorder and often associated with early-onset osteoarthritis. This new clinical entity, called aneurysms-osteoarthritis syndrome (AOS) or Loeys-Dietz syndrome 3 (LDS3), is characterized by aggressive arterial damages such as aneurysms, dissections and tortuosity throughout the arterial tree. We report, here, the case of a 45 year-old man presenting multiple visceral arteries and abdominal aortic aneurysms but without dissection of the thoracic aorta and without any sign of osteoarthritis. Read More

    Glycated Hemoglobin Is Associated With the Growth Rate of Abdominal Aortic Aneurysms: A Substudy From the VIVA (Viborg Vascular) Randomized Screening Trial.
    Arterioscler Thromb Vasc Biol 2017 Feb 9. Epub 2017 Feb 9.
    From the Elitary Research Centre of Individualized Medicine in Arterial Disease (K.L.K., L.M.R., J.S.L.), Department of Cardiac, Thoracic, Vascular Surgery (K.L.K., J.S.L.); The Danish Diabetes Academy (K.L.K.), and Department of Clinical Biochemistry and Pharmacology (L.M.R.), Odense University Hospital, Denmark; and Cardiovascular Research Unit, Region Hospital Viborg, Denmark (M.D., J.S.L.).
    Objective: An inverse association between abdominal aortic aneurysms (AAAs) and diabetes mellitus exists; however, the cause remains unknown. This study aimed to evaluate whether the degree of glycemia is associated with aneurysm growth.

    Approach And Results: The study was based on VIVA trial (Viborg Vascular), the randomized clinically controlled screening trial for abdominal aortic aneurysm in men aged 65 to 74 years in the Central Denmark Region. Read More

    Relationship between normal preoperative white blood cell count and major adverse events after endovascular repair for abdominal aortic aneurysm: results of a pilot study.
    J Clin Anesth 2017 Feb 8;36:201-205. Epub 2016 Dec 8.
    Department of Surgery-Vascular Surgery Unit, School of Medicine, University of Ioannina, Ioannina, Greece.
    Study Objective: To examine the association between preoperative white blood cell (WBC) count within the reference range and major adverse events (MAEs) following endovascular repair of abdominal aortic aneurysms (AAA).

    Design: Prospective observational study.

    Setting: Vascular surgery clinic in a tertiary university hospital. Read More

    Risk of cardiovascular disease among patients with sarcoidosis: a population-based retrospective cohort study, 1976-2013.
    Eur Respir J 2016 Dec 23. Epub 2016 Dec 23.
    Division of Rheumatology, Dept of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
    A higher incidence of cardiovascular disease (CVD) has been observed in several chronic inflammatory diseases. However, data on sarcoidosis are limited.In this study, 345 patients with incident sarcoidosis in Olmsted County (Minnesota, USA) during 1976-2013 were identified based on comprehensive medical record review. Read More

    Particulate Release From Nanoparticle-Loaded Shape Memory Polymer Foams.
    J Med Device 2017 Mar 16;11(1):0110091-110099. Epub 2017 Jan 16.
    Biomedical Engineering, Texas A&M University, College Station, TX 77843; Shape Memory Medical, Inc., Santa Clara, CA 95054 e-mail: 
    Highly porous, open-celled shape memory polymer (SMP) foams are being developed for a number of vascular occlusion devices. Applications include abdominal aortic and neurovascular aneurysm or peripheral vascular occlusion. A major concern with implanting these high surface area materials in the vasculature is the potential to generate unacceptable particulate burden, in terms of number, size, and composition. Read More

    Pravastatin activates activator protein 2 alpha to argument the angiotensin II-induced abdominal aortic aneurysms.
    Oncotarget 2017 Feb 4. Epub 2017 Feb 4.
    Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, China.
    We have previously reported that activation of AMP-activated kinase alpha 2 (AMPKα2) by nicotine or angiotensin II (AngII) instigates formation of abdominal aortic aneurysms (AAA) in Apoe-/- mice. Statins, used to treat hyperlipidemia widely, activate AMPK in vascular cells. We sought to examine the effects of pravastatin on AAA formation and uncover the molecular mechanism. Read More

    Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases.
    Oncotarget 2017 Feb 4. Epub 2017 Feb 4.
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.
    Abdominal aortic aneurysm (AAA) affects more than 5% of the population in developed countries and the pharmacotherapies for AAA are limited. Here, we explored whether melatonin regulates the development of AAA. In smooth muscle cells, melatonin treatment decreases angiotensin II-induced matrix metalloproteinase 2 (MMP2) and MMP9 expression. Read More

    Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study.
    J Neurointerv Surg 2017 Feb 8. Epub 2017 Feb 8.
    Department of Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands.
    Background: More challenging animal models are needed to elucidate the efficacy of flow diverter (FD) designs and the mechanisms behind observed complications. The purpose of this study is to demonstrate the feasibility of implanting a FD in a sidewall aneurysm rat model.

    Methods: An end-to-side anastomosis was created in the abdominal aorta of 36 rats using a decellularized donor pouch. Read More

    Hospital Teaching Status and Medicare Expenditures for Complex Surgery.
    Ann Surg 2017 Mar;265(3):502-513
    *Center for Healthcare Outcomes and Policy, University of Michigan, Ann Arbor, MI †The University of Michigan Medical School, University of Michigan, Ann Arbor, MI ‡The Department of Surgery, University of Michigan, Ann Arbor, MI.
    Objective: To evaluate the relationship between hospital teaching intensity, Medicare payments, and perioperative outcomes.

    Background: Several emerging payment policies penalize hospitals for low-value healthcare. Teaching hospitals may be at a disadvantage given the perception that they deliver care less efficiently. Read More

    Safety and Efficacy of Totally Percutaneous Access Compared With Open Femoral Exposure for Endovascular Aneurysm Repair.
    J Endovasc Ther 2017 Feb 1:1526602816689679. Epub 2017 Feb 1.
    1 Department of Vascular Surgery, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
    Purpose: To compare the safety and efficacy of percutaneous (PEVAR) vs open femoral access (OFA) techniques for endovascular aneurysm repair (EVAR).

    Methods: A systematic review of English-language articles (Medline, EMBASE, and Cochrane databases) between January 1999 and August 2016 returned 11 studies including 1650 patients with 2500 groin accesses eligible for the meta-analysis. Data extracted from each study were synthesized to evaluate technical success rates, procedure time, and complications for the 2 access approaches. Read More

    Novel Pathogenic Variant in TGFBR2 Confirmed by Molecular Modeling Is a Rare Cause of Loeys-Dietz Syndrome.
    Case Rep Genet 2017 9;2017:7263780. Epub 2017 Jan 9.
    Department of Clinical Genomics, Center for Individualized Medicine, Mayo Clinic, Jacksonville, FL, USA; Division of Medical Genetics, Department of Pediatrics, Stanford University, Stanford, CA, USA.
    Loeys-Dietz syndrome (LDS) is a connective tissue disorder characterized by vascular findings of aneurysm and/or dissection of cerebral, thoracic, or abdominal arteries and skeletal findings. We report a case of a novel pathogenic variant in TGFBR2 and phenotype consistent with classic LDS. The proband was a 10-year-old presenting to the genetics clinic with an enlarged aortic root (Z-scores 5-6), pectus excavatum, and congenital contractures of the right 2nd and 3rd digit. Read More

    Abdominal pain in presence of small abdominal aortic aneurysms: If in doubt, cut it out!
    Ann Vasc Surg 2017 Feb 2. Epub 2017 Feb 2.
    Medical School, Democritus University of Thrace; Department of Vascular Surgery, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
    Although small (<5cm) Abdominal Aortic Aneurysm (AAA) have been associated with symptoms and indication for intervention scarcely, the clinicians should never exclude such potential association especially in the absence of other overt pathological findings. In such cases, a surgical exploration with consequent intervention, if feasible, should be justified in order to prevent a detrimental evolution in a dubious scenario. In this article we present two cases of patients with small AAA presenting with severe abdominal pain. Read More

    Treatment of an aortic arch aneurysm with scalloped and fenestrated thoracic stent-graft and left carotid to subclavian artery bypass.
    Ann Vasc Surg 2017 Feb 2. Epub 2017 Feb 2.
    Department of Vascular Surgery, Singapore General Hospital. Electronic address:
    We report a successful treatment of thoracic arch aneurysm using a combination of hybrid approach and a customized stent graft in a frail patient with challenging anatomy and concomitant large retrosternal goiter. The patient is an 82-year-old lady with multiple comorbidities who presented to her general practitioner for anorexia and significant weight loss. She was incidentally found to have a 6. Read More

    Thrombosis of the inferior vena cava after endovascular aortic repair in a patient with May-Thurner syndrome: case report and literature review.
    Ann Vasc Surg 2017 Feb 2. Epub 2017 Feb 2.
    Department of Vascular and Endovascular Surgery, Goethe-University-Hospital Frankfurt am Main, Germany. Electronic address:
    Inferior vena cava (IVC) thrombosis is a rare complication of abdominal aortic aneurysm (AAA). A 70-year-old male patient of Italian origin presented with a 9.3 x 8. Read More

    Endovascular management of para-prosthetic aortocaval fistula: case report and systematic review of the literature.
    Ann Vasc Surg 2017 Feb 2. Epub 2017 Feb 2.
    Unit of Vascular Surgery, Department of Surgical Sciences, University of Parma, Ospedale Maggiore, Parma, Italy.
    The aim of this article is to report a case of asymptomatic para-anastomotic aortocaval fistula (ACF) treated by endovascular aortic repair, and to review data of the literature on arteriovenous fistulae (AVF) secondary to abdominal aortic surgery. A 78-year-old male complained of worsening pain in the right lower limb since 2 months. He presented a history of right femoro-popliteal bypass for peripheral arterial occlusive disease and elective surgical treatment for a non-ruptured infrarenal aortic aneurysm (Dacron tube graft). Read More

    Monocentric evaluation of chimney versus fenestrated endovascular aortic repair for juxta-renal abdominal aortic aneurysm.
    Ann Vasc Surg 2017 Feb 1. Epub 2017 Feb 1.
    Unit of vascular surgery, université de Bordeaux, CHU de Bordeaux, France. Electronic address:
    Background: With approval of on-label fenestrated (F-) endovascular aortic repair (EVAR), concerns regarding long-term patency and endoleaks (ELs) after chimney graft (CG)-EVAR were raised. To add supportive data on the value of this technique, we chose to report the mid-term results of CG-EVAR in a single center with standardized methods and to compare them to F-EVAR.

    Methods: A retrospective analysis of prospectively gathered data from January 2010 to January 2015 was conducted and patients with excessive comorbidities for open repair treated by CG-EVAR or F-EVAR were included. Read More

    Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.
    Br J Surg 2017 Feb;104(3):166-178
    Vascular Surgery Research Group, Imperial College London, London, UK.
    Background: The erosion of the early mortality advantage of elective endovascular aneurysm repair (EVAR) compared with open repair of abdominal aortic aneurysm remains without a satisfactory explanation.

    Methods: An individual-patient data meta-analysis of four multicentre randomized trials of EVAR versus open repair was conducted to a prespecified analysis plan, reporting on mortality, aneurysm-related mortality and reintervention.

    Results: The analysis included 2783 patients, with 14 245 person-years of follow-up (median 5·5 years). Read More

    IgG4-positive cell infiltration in various cardiovascular disorders - results from histopathological analysis of surgical samples.
    BMC Cardiovasc Disord 2017 Feb 3;17(1):52. Epub 2017 Feb 3.
    Department of Cardiology, Osaka Medical College, Daigaku-machi 2-7, Takatsuki, Osaka, 569-8686, Japan.
    Background: The diagnosis of Immunoglobulin G4 (IgG4)-related disease (IgG4-RD), in general, depends on serum IgG4 concentrations and histopathological findings; therefore, diagnosis of IgG4-RD in cardiovascular organs/tissues is often difficult owing to the risk of tissue sampling.

    Methods: Prevalence of IgG4-positive lymphoplasmacytic infiltration in 103 consecutive cardiovascular surgical samples from 98 patients with various cardiovascular diseases was analyzed immunohistochemically.

    Results: The diagnoses of the enrolled patients included aortic aneurysm (abdominal, n = 8; thoracic, n = 9); aortic dissection (n = 20); aortic stenosis (n = 24), aortic regurgitation (n = 10), and mitral stenosis/regurgitation (n = 17). Read More

    Influence of endoleak positions on the pressure shielding ability of stent-graft after endovascular aneurysm repair (EVAR) of abdominal aortic aneurysm (AAA).
    Biomed Eng Online 2016 Dec 28;15(Suppl 2):135. Epub 2016 Dec 28.
    Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
    Background: Abdominal aortic aneurysm (AAA) is a kind of dangerous aortic vascular disease, which is characterized by abdominal aorta partial enlargement. At present, endovascular aneurysm repair (EVAR) is one of the main treatments of abdominal aortic aneurysm. However for some patients after EVAR the aneurysm re-expanded and even ruptured, leading to poor postoperative effect. Read More

    Hemodynamics study of a multilayer stent for the treatment of aneurysms.
    Biomed Eng Online 2016 Dec 28;15(Suppl 2):134. Epub 2016 Dec 28.
    Department of Applied Mechanics, Sichuan University, 610065, Chengdu, China.
    Background: The changes of hemodynamics caused by the implantation of multilayer stent (MS) have significant effects for aneurysm sac.

    Methods: Comparisons of 3D numerical models with/without a MS in an abdominal aortic aneurysm with a 90° branch vessel were numerically studied from the viewpoint of hemodynamics.

    Results: The results showed that: (1) The flow fields and Wall Shear Stress (WSS) are changed dramatically after MS implantation. Read More

    Serum Calprotectin as a novel biomarker in abdominal aortic aneurysm pathogenesis and progression: Preliminary data from experimental model in rats.
    Curr Vasc Pharmacol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States.
    Background: Abdominal aortic aneurysm (AAA) formation is associated with by inflammation and matrix degradation. This study tested the hypothesis that calprotectin, a novel biomarker for inflammation, as well as established biomarkers such as C-reactive protein (CRP) and matrix metalloproteinase-9 (MMP-9) could also be indicative inflammatory biomarkers during AAA pathogenesis and progression. We also evaluated the correlation of serum soluble Receptor for Advanced Glycation End Products (sRAGE) with AAA diameter and serum calprotectin levels. Read More

    NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.
    Arterioscler Thromb Vasc Biol 2017 Feb 2. Epub 2017 Feb 2.
    From the Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery (D.W., P. R., Y.Z., L.Z., G.X., W.X., J.S.C., Q.Z., Y.H.S., S.A.L.), Cardiovascular Research Institute (J.S.C., Y.H.S., S.A.L.), and Department of Molecular Physiology and Biophysics (D.W., E.E.L., S.A.L.), Baylor College of Medicine, Houston, TX; Department of Cardiovascular Surgery, Texas Heart Institute, Houston (D.W., G.X., L.Z., W.X., J.S.C., S.A.L.); Cardiology MD Anderson Cancer Center, Houston, Texas (S.Z.); Division of Vascular Surgery, Vanderbilt University School of Medicine, Nashville, TN (J.A.C.); and Division of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston (D.M.M).
    Objective: Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and aortic aneurysm and dissection (AAD) development. However, the mechanisms underlying SMC contractile dysfunction in sporadic AAD are poorly understood. In this study, we examined the role of the NLRP3 (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3)-caspase-1 inflammasome, a key inflammatory cascade, in SMC contractile dysfunction in AAD. Read More

    Aortic and splanchnic artery aneurysms: Unusual causes of biliary obstruction - A retrospective cohort from literature.
    Int J Surg 2017 Jan 30;39:163-168. Epub 2017 Jan 30.
    Division of Gastroenterology, Department of Medicine, Maimonides Medical Center, Brooklyn, NY, USA; Albert Einstein College of Medicine, NY, USA. Electronic address:
    Mechanical obstruction of the biliary tree and resultant stasis are the cornerstone of a spectrum of diseases ranging from biliary colic to fulminant cholangitis. Infrequently acquired abnormalities of the abdominal vasculature can lead to biliary obstruction. In 2010, we reported a case of acute cholangitis resulting from compression of extra hepatic bile duct by an abdominal aortic aneurysm (AAA). Read More

    Esophageal transection.
    Ulus Cerrahi Derg 2016 1;32(4):281-284. Epub 2016 Dec 1.
    Department of General Surgery, Istanbul University Istanbul School of Medicine, Istanbul, Turkey.
    Herein, a case of intramural esophageal dissection is reported and the literature is reviewed. Intramural esophageal dissection is a rare but well described condition that is characterized by a laceration between the esophageal mucosa and submucosa but without perforation. A female patient aged 86 years was hospitalized with a diagnosis of abdominal aortic aneurysm. Read More

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