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Exp Clin Endocrinol Diabetes 2022 Jun 27. Epub 2022 Jun 27.

Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen City 518036, Guangdong Province, P.R. China.

Objective: Diabetic cardiomyopathy (DCM) constitutes a primary cause of mortality in diabetic patients. Histone deacetylase (HDAC) inhibition can alleviate diabetes-associated myocardial injury. This study investigated the mechanism of HDAC1 on myocardial fibrosis (MF) in DCM. Read More

Ann Vasc Surg 2022 Jun 24. Epub 2022 Jun 24.

Department of Cardiovascular Surgery, CHU Liege, Belgium.

Objective: The improvement in survival rates for heart transplant recipients (HTRs) has increased their risk of developing extracardiac diseases such as abdominal aortic aneurysms (AAAs). The purposes of this study were to evaluate the prevalence and to describe the clinical features and natural history of AAA in HTRs.

Methods: A retrospective review of all patients (375) who underwent heart transplantation (HT) at our center over a 32-year period (1983-2015) was carried out. Read More

Int Immunopharmacol 2022 Jun 24;110:108938. Epub 2022 Jun 24.

Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address:

The immune response is of great significance in the initiation and progression of a diversity of cardiovascular diseases involving pro-and anti-inflammatory cytokines. Interleukin-35 (IL-35), a cytokine of the interleukin-12 family, is a novel anti-inflammation and immunosuppressive cytokine, maintaining inflammatory suppression and regulating immune homeostasis. The role of IL-35 in cardiovascular diseases (CVDs) has aroused enthusiastic attention, a diversity of experimental or clinical evidence has indicated that IL-35 potentially has a pivot role in protecting against cardiovascular diseases, especially atherosclerosis and myocarditis. Read More

Radiologie (Heidelb) 2022 Jun 27. Epub 2022 Jun 27.

Klinik für Radiologie, Charité - Universitätsmedizin Berlin, Charitépl. 1, 10117, Berlin, Deutschland.

Background: Abdominal aortic aneurysms can either be treated by open surgery or endovascular repair. In both cases, prostheses are implanted to prevent potentially lethal aortic ruptures.

Objectives: Studies seeking to identify the optimal treatment came to diverging conclusions. Read More

Swiss Med Wkly 2022 Jun 27;152:w30191. Epub 2022 Jun 27.

Department for Vascular Surgery, University Hospital Zurich, Switzerland.

Aim Of The Study: To analyse hospital incidence and in-hospital mortality of patients treated for abdominal aortic aneurysms in Switzerland.

Methods: Secondary data analysis of case-related hospital discharge data of the Swiss Federal Statistical Office for the years 2009-2018. Patients who were hospitalised and surgically treated for nonruptured abdominal aortic aneurysms or hospitalised and treated for ruptured abdominal aortic aneurysms were included in the analysis. Read More

J Vasc Surg 2022 Jun 22. Epub 2022 Jun 22.

Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, Case Western Reserve University School of Medicine/University Hospitals, Cleveland Medical Center, Cleveland, OH. Electronic address:

Objectives: Interfacility transfer (IT) of patients with ruptured (r) abdominal aortic aneurysm (AAA) occurs not infrequently for a higher level of care. This study evaluates using contemporary administrative database the impact of IT on mortality after rAAA repair.

Methods: Healthcare Cost and Utilization Project Database for NY (2016) and NJ/MD/FL (2016-2017) were queried using ICD-10 edition to identify patients who underwent open and endovascular repair of AAA. Read More

J Vasc Nurs 2022 Jun 17;40(2):92-99. Epub 2022 Feb 17.

Vascular Research Unit, Department of Surgery, Viborg Regional Hospital, Viborg, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Objectives: To explore patients' perspectives on living with an abdominal aorta aneurysm (AAA) to obtain understanding of how to address their needs by changes in infrastructures in AAA surveillance.

Background: In outpatient care, patients with AAA are offered surveillance by annual or biannual ultrasound scans to monitor AAA progression. When AAA exceeds 50 mm in women and 55 mm in men, surgical interventions are recommended to prevent rupture. Read More

Vasc Specialist Int 2022 Jun 24;38:17. Epub 2022 Jun 24.

Department of Vascular Surgery, School of Medicine, University of Patras, Patras, Greece.

The ALTO abdominal stent graft system (Endologix Inc., Irvine, CA, USA) is a latest-generation polymer-based device used to treat patients with abdominal aortic aneurysms. The present study describes the first case series of patients with abdominal aortic aneurysms, including two patients with juxtarenal aneurysms, treated using the ALTO stent graft system. Read More

Nutrients 2022 Jun 12;14(12). Epub 2022 Jun 12.

Department of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, 15-089 Bialystok, Poland.

Abdominal aortic aneurysm (AAA) is a local dilatation of the vessel equal to or exceeding 3 cm. It is a disease with a long preclinical period commonly without any symptoms in its initial stage. Undiagnosed for years, aneurysm often leads to death due to vessel rupture. Read More

Life (Basel) 2022 May 31;12(6). Epub 2022 May 31.

Instituto de Investigación Sanitaria de Navarra-IdiSNA, 31008 Pamplona, Spain.

Predicting the progression of small aneurysms is a main challenge in abdominal aortic aneurysm (AAA) management. The combination of circulating biomarkers and image techniques might provide an alternative for risk stratification. We evaluated the association of plasma TAT complexes (TAT) and D-dimer with AAA severity in 3 groups of patients: group 1, without AAA ( = 52), group 2, AAA 40-50 mm ( = 51) and group 3, AAA > 50 mm ( = 50). Read More

J Pers Med 2022 May 31;12(6). Epub 2022 May 31.

Department of Vascular Surgery, Nuestra Señora del Rosario Hospital, 28834 Madrid, Spain.

Information on the quality of life of patients operated on for abdominal aortic aneurysm (AAA) is scarce. The objective of this study was to analyse these patients' health-related quality of life (HRQoL). This was a cross-sectional observational study. Read More

J Clin Med 2022 Jun 16;11(12). Epub 2022 Jun 16.

Chair and Department of Biology and Genetics, Medical University of Lublin, 4a Chodźki St., 20-093 Lublin, Poland.

A growing body of evidence indicates a crucial role of miRNA regulatory function in a variety of mechanisms that contribute to the development of diseases. In our previous work, alterations in miRNA expression levels and targeted genes were shown in peripheral blood mononuclear cells (PBMCs) from patients with lower extremity artery disease (LEAD), abdominal aortic aneurysm (AAA), and chronic venous disease (CVD) in comparison with healthy controls. In this paper, previously obtained miRNA expression profiles were compared between the LEAD, AAA, and CVD groups to find either similarities or differences within the studied diseases. Read More

J Clin Med 2022 Jun 7;11(12). Epub 2022 Jun 7.

Department of Vascular and Endovascular Surgery, University Hospital of Heidelberg, 69120 Heidelberg, Germany.

Gene expression profiling of abdominal aortic aneurysms (AAA) indicates that chronic inflammatory responses, active matrix metalloproteinases, and degradation of the extracellular matrix components are involved in disease development and progression. This study investigates intra- and interpersonal RNA genome-wide expression profiling differences (Illumina HumanHT-12, BeadCHIP expression) of 24 AAA biopsies from 12 patients using a single gene and pathway (GeneOntology, GO enrichment) analysis. Biopsies were collected during open surgical AAA repair and according to prior finite element analysis (FEA) from regions with the highest and lowest wall stress. Read More

Int J Mol Sci 2022 Jun 7;23(12). Epub 2022 Jun 7.

UMR CNRS 6015-INSERM U1083, IRIS2, 3 rue Roger Amsler, 49100 Angers, France.

Aneurysm is the second-most common disease affecting the aorta worldwide after atherosclerosis. While several clinical metabolomic studies have been reported, no study has reported deep metabolomic phenotyping in experimental animal models of aortic aneurysm. We performed a targeted metabolomics study on the blood and aortas of an experimental mice model of aortic aneurysm generated by high-cholesterol diet and angiotensin II in Ldlr mice. Read More

Biomedicines 2022 Jun 18;10(6). Epub 2022 Jun 18.

Department of Vascular and Endovascular Surgery, University Hospital Münster, 48149 Münster, Germany.

(1) Successful endovascular repair for abdominal aortic aneurysms is based on the complete exclusion of the aneurysm sac from the systemic circulation. Type Ia endoleak (ELIA) is defined as the persistent perfusion of the aneurysm sac due to incomplete proximal sealing between aorta and endograft, with a consequent risk of rupture and death. Endoleak embolization has been sporadically reported as a viable treatment for ELIA. Read More

Vascular 2022 Jun 23:17085381221111012. Epub 2022 Jun 23.

Department of Vascular Surgery, 34379Royal Hobart Hospital, Hobart, TAS, Australia.

Background: Pseudoaneurysms of the abdominal aorta secondary to pancreatitis are an extremely rare clinical entity, however, can result in life threatening complications.

Objective: To describe a chimney endovascular aneurysm repair (Ch-EVAR) for an acute pancreatitis related paravisceral aortic pseudoaneurym.

Method: Prospective data collected from subject. Read More

J Vasc Surg 2022 Jul;76(1):40-41

Division of Vascular Surgery, Indiana University, Indianapolis, IN. Electronic address:

Radiologie (Heidelb) 2022 Jun 23. Epub 2022 Jun 23.

Institut für Radiologie, Neuroradiologie und minimal-invasive Therapie, München Klinik Bogenhausen, München, Deutschland.

Clinical/methodical Issue: In the last 20 years, the treatment of abdominal aortic aneurysms has essentially evolved from surgical to minimally invasive endovascular treatment.

Achievements: There are still a number of clinical situations that make surgical intervention useful or even necessary. This underlines the importance of interdisciplinary vascular centers for the treatment of complex aortic pathologies and their sequelae. Read More

J Endovasc Ther 2022 Jun 23:15266028221102658. Epub 2022 Jun 23.

Vascular Surgery Unit, University Hospital de Alava, Vitoria-Gasteiz, Spain.

Purpose: The widespread adoption of endovascular aneurysm repair (EVAR) as preferred treatment modality for abdominal aortic aneurysm (AAA) has enlarged the number of patients needing open surgical conversion (OSC). The relationship between adherence to Instructions For Use (IFU) and EVAR long-term outcomes remains controversial. The aim of this study is to compare preoperative differences and postoperative outcomes between EVAR patients not adjusted to IFU and adjusted to IFU who underwent OSC. Read More

J Endovasc Ther 2022 Jun 23:15266028221105186. Epub 2022 Jun 23.

Department of Vascular Surgery, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.

Introduction: Initiating an endovascular aortic program for treatment of complex aortic aneurysms with fenestrated and branched grafts (FB-EVAR) is challenging. Using a Proctor is one option for training and development of the team. However, this approach has not been formally analyzed. Read More

JACC Case Rep 2022 Jun 15;4(12):742-750. Epub 2022 Jun 15.

Department of Vascular Surgery, NCH Healthcare System, Naples, Florida, USA.

We describe a complication following transfemoral transcatheter aortic valve replacement in a patient who underwent remote endovascular abdominal aortic aneurysm repair. This report highlights technical complications to be vigilant of when using intravascular catheterization in patients with previous aneurysm repair while also showcasing synchronous type 3 endoleaks at multiple sites. (). Read More

BMC Surg 2022 Jun 22;22(1):241. Epub 2022 Jun 22.

Department of Surgery, Fukuyama City Hospital, 5-23-1 Zao, Fukuyama, Hiroshima, 721-8511, Japan.

Background: The treatment of delayed complications after liver trauma such as bile leakage (BL) and hepatic artery pseudoaneurysms (HAPs) is difficult. The purpose of this study is to investigate the outcomes and management of post-traumatic BL and HAPs.

Methods: We retrospectively evaluated patients diagnosed with blunt liver injury, graded by the American Association for the Surgery of Trauma Liver Injury Scale, who were admitted to our hospital between April 2010 and December 2019. Read More

Int J Emerg Med 2022 Jun 22;15(1):28. Epub 2022 Jun 22.

Philadelphia College of Osteopathic Medicine, 4170 City Ave, PhiladelphiaPhiladelphia, PA, 19131, USA.

Background: Abdominal aortic aneurysms (AAA) can present asymptomatically and may be found through routine screening or seen incidentally on imaging. Rupture due to weaking of the aortic wall is the main complication of an AAA and leads to approximately 200,000 deaths annually worldwide. Clinically, AAA rupture most frequently presents with abdominal and/or back pain, pulsatile abdominal mass, and hypotension. Read More

Intern Med 2022 Jun 21. Epub 2022 Jun 21.

Department of Respiratory Medicine, Seirei Hamamatsu General Hospital, Japan.

A 71-year-old man was admitted for left-sided chest pain. He had a history of diabetes, treatment with epidermal growth factor receptor-tyrosine kinase inhibitor for advanced non-small-cell lung cancer, and corticosteroid treatment for underlying lung diseases. Chest computed tomography showed consolidations in the bilateral lower lobes, and Aspergillus fumigatus was detected by bronchoscopy. Read More

Comput Methods Biomech Biomed Engin 2022 Jun 21:1-20. Epub 2022 Jun 21.

Department of Cardiology, Institute of Medical Science, BHU, Varanasi, Uttar Pradesh, India.

The study of patient-specific human arterial flow dynamics is well known to face challenges like a) apt geometric modelling, b) bifurcation zone meshing, and c) capturing the hemodynamic prone to variations with multiple disease complications. Due to aneurysms and stenosis in the same arterial network, the blood flow dynamics get affected, which needs to be explored. This study develops a new protocol for accurate geometric modelling, bifurcation zone meshing and numerically investigates the arterial network with abdominal aortic aneurysms (AAA) and right internal iliac stenosis (RIIAS). Read More

Radiologie (Heidelb) 2022 Jun 20. Epub 2022 Jun 20.

Abteilung für Kardiovaskuläre und Interventionelle Radiologie, Universitätsklinik für Radiologie und Nuklearmedizin, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Background: Today, complex abdominal aortic pathologies involving the visceral arteries and without an adequate proximal neck can be treated using fenestrated/branched endovascular aortic repair (FEVAR/BEVAR) with similar safety and success rates as infrarenal aortic pathologies treated with tubular EVAR.

Methodical Innovations And Challenges: Fenestrations (if the vessel originates from a nondilated aorta) or branches (if the vessel originates from a dilated aorta) may be used for the visceral arteries. Both types of openings are sealed via bridging stent grafts that connect to the target vessel. Read More

Cardiovasc Drugs Ther 2022 Jun 20. Epub 2022 Jun 20.

Department of Cardiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Purpose: Recent studies demonstrated that pyroptosis is involved in abdominal aortic aneurysm (AAA) progression, suggesting a potential target for AAA treatment. This study aimed to identify if disulfiram could inhibit angiotensin II (Ang II)-induced vascular smooth muscle cells (VSMCs) damage, thereby exerting protective effects on AAA.

Methods: The AAA mouse model was established by continuous subcutaneous Ang II infusion for 28 days. Read More

Am Surg 2022 Jun 19:31348221109464. Epub 2022 Jun 19.

Surgical & Perioperative Careline, Department of Surgery, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

Introduction: Access to surgical service is limited by provider availability and geographic barriers. Telemedicine ensures that patients can access medical care.

Objective: The objective is to describe our use of telemedicine in delivering vascular surgery services to remote locations before and during the COVID-19 pandemic. Read More

Ann Transl Med 2022 May;10(10):547

Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Background: N6-methyladenosine (m6A) is found in almost all nuclear RNAs of eukaryotes, playing an important and diverse role in many biological processes. Nonetheless, the roles of m6A regulators in abdominal aortic aneurysm (AAA) unknown. Therefore, there is a pressing need to identify m6A RNA methylation regulators in the diagnosis of AAA, determination of individualized risk, discovery of therapeutic targets, and improve understanding of pathogenesis. Read More

Front Cardiovasc Med 2022 3;9:890228. Epub 2022 Jun 3.

Department of General and Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China.

Background: Etiology and risk factors of peripheral artery disease (PAD) include age, smoking, and hypertension, etc. , which are shared by an abdominal aortic aneurysm (AAA). Concomitance with AAA in patients with PAD is not rare but is easily overlooked in the clinical situation, though management strategies are altered totally. Read More