J Cutan Pathol 2017 Sep 5;44(9):786-789. Epub 2017 Jul 5.

Electron Microscopy, EMBRAPA-CPA-CT, Pelotas, Brazil.

Anetoderma is a rare cutaneous disorder characterized by focal loss of dermal elastic tissue due to unknown mechanisms. Primary anetoderma develops on clinical normal skin, without any preceding dermatosis and it can be associated with autoimmune conditions. Secondary anetoderma develops on the same area of a previous disorder, such as infectious, neoplastic or inflammatory diseases. Read More

Int J STD AIDS 2017 Jan 1:956462417713586. Epub 2017 Jan 1.

4 Private Practice in São Paulo, São Paulo, Brazil.

Anetoderma is a rare benign condition of diverse etiology whose characteristic is the diminution or absence of the dermal elastic fibers. Classified as primary and secondary, the latter associated with tumors, inflammatory, and infectious diseases. Although the etiology of the lesions is well described in literature, the pathogenesis is still poorly determined. Read More

Reumatol Clin 2017 Mar 28. Epub 2017 Mar 28.

Facultad de Medicina, Unidad de Patología Centro, Universidad de Chile, Las Condes, Santiago de Chile, Chile.

Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.

Harvard Medical School, Boston, MA, USA. fandi_xia@ hms.harvard.edu.

Introduction: Anetoderma is an elastolytic skindisorder that has been associated with the presenceof antiphospholipid antibodies (aPL). Patients withantiphospholipid antibody-positive anetoderma havebeen reported to develop symptoms of Graves disease,antiphospholipid syndrome, and other autoimmuneconditions. The temporal relationship, however,between anetoderma onset and the emergence ofaPL remains unclear, a clarification of which may haveimplications for the screening and monitoring ofpatients with anetoderma. Read More

Clin Med (Lond) 2017 Feb;17(1):40-42

National University Health System, Singapore and Yong Loo Lin School of Medicine, National University Singapore, Singapore.

A 58-year-old Chinese woman with well controlled type 1 diabetes mellitus presented with acute and progressive bilateral lower limb weakness. Investigations revealed severe hypokalaemia (1.3 mmol/L) and hypophosphataemia (<0. Read More

J Immunol Res 2016 28;2016:4325463. Epub 2016 Dec 28.

Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background. The clinical and histopathologic classification of anetoderma are not well characterized. Objective. Read More

G Ital Dermatol Venereol 2016 Oct;151(5):566-9

Department of Dermatology and Venereology, Ege University Faculty of Medicine, Izmir, Turkey -

JAMA Dermatol 2016 Nov;152(11):1239-1243

Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Importance: Infantile hemangiomas involute to some extent, but they often leave sequelae that may cause disfigurement. Factors determining the risk of permanent sequelae after regression are of crucial importance in treatment decision making.

Objectives: To describe the sequelae left by infantile hemangiomas after natural involution and to identify clinical characteristics that could predict the most severe or a particular type of sequelae. Read More

Med Clin (Barc) 2016 Oct 5;147(8):e47. Epub 2016 Mar 5.

Servicio de Dermatología, Hospital Universitario Doce de Octubre, Madrid, España.

Int J Dermatol 2016 Jul 5;55(7):739-44. Epub 2016 Mar 5.

Kempf und Pfaltz Histologische Diagnostik, Research Unit, Zurich, Switzerland.

Patients with a lymphoma have an increased risk of developing a second lymphoproliferative disorder. The association of nodal Hodgkin lymphoma and primary cutaneous marginal zone lymphoma (MALT type) is exceptional, and only very few cases have been documented. Anetoderma represents a circumscribed loss or rarefication of elastic fibers. Read More

Acta Derm Venereol 2016 08;96(6):828-9

Unit of Dermatology, University of Padua, Via C. Battisti 206, IT-35128 Padova, Italy.

Acta Derm Venereol 2016 06;96(5):708-10

Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Gudrunstr. 56, DE-44791 Bochum, Germany.

G Ital Dermatol Venereol 2016 Feb 18;151(1):130-1. Epub 2015 Nov 18.

Section of Dermatology and Venereology, Departmen of Surgery and Translational Medicine, P. Palagi Hospital, University of Florence, School of Health Sciences, Florence, Italy.

Ann Dermatol Venereol 2015 Nov 3;142(11):716-8. Epub 2015 Sep 3.

Service de dermatologie et vénéreologie, CHU Ibn Sina, université Mohammed V, 6, immeuble 60, résidence Al Boustane, Souissi, Rabat, Maroc.

Aesthetic Plast Surg 2015 Dec 26;39(6):968-70. Epub 2015 Aug 26.

Vascular Anomalies Program of Lenox Hill Hospital, 210 East 64th Street - 7th Floor, New York, NY, 10065, USA.

Unlabelled: I was asked to provide a commentary for "Shouldn't Propranolol be Used to Treat All Hemangiomas?" by Moodley et al. (Aesth Plast Surg, 2015. doi: 10. Read More

Am J Med Genet A 2015 Oct 8;167A(10):2459-62. Epub 2015 Jun 8.

Department of Dermatology, University of Iowa Hospitals and Clinics.

Terminal osseous dysplasia with pigmentary defects (TODPD) is a rare, X-linked syndrome classically characterized by distal limb anomalies, pigmented skin defects of the face, and recurrent digital fibromas. X-inactivation plays a major role in determining the range of phenotypic expression. Thus, patients can demonstrate a wide spectrum of disease severity, making accurate diagnosis more challenging. Read More

J Cosmet Laser Ther 2016 3;18(1):38-40. Epub 2015 Jul 3.

a Dermatology and Cutaneous Biology, Jefferson University Hospitals , Philadelphia , PA , USA.

Anetoderma is a skin disorder characterized by a focal loss of dermal elastic tissue whereby patients present with soft, depressible lesions. We postulated that a series of combination treatment using the 595-nm pulsed dye laser (PDL) and the 1550-nm non-ablative fractionated laser (NAFL) would improve the anetoderma lesions. Our patient with biopsy proven anetoderma received 3 treatments with a combination of 595-nm PDL and 1550-nm NAFL spaced 3 weeks apart. Read More

J Cutan Pathol 2015 Oct 4;42(10):765-8. Epub 2015 Jun 4.

Department of Dermatology and Dermatopathology, Cleveland Clinic, Cleveland, OH, USA.

Anetoderma is a cutaneous disorder characterized by loss of dermal elastic tissue resulting in papules from herniation of subcutaneous tissue or circumscribed areas of atrophic, wrinkled skin. Familial leiomyomatosis cutis et uteri (Reed syndrome) is an autosomal dominant disorder characterized by cutaneous and uterine leiomyomas. We report a 23-year-old male with Reed syndrome who presented with asymptomatic pearly white, atrophic, flaccid papules on the upper back and shoulder that depressed when palpated. Read More

Eur J Dermatol 2015 May-Jun;25(3):277-9

CHU Dupuytren, 2 Avenue Martin Luther King, 87042 Limoges, France.

Indian J Dermatol 2015 Mar-Apr;60(2):215

Department of Pathology, Subharti Medical College, Meerut, Uttar Pradesh, India.

Primary anetoderma is a rare idiopathic disease of the skin, characterized by circumscribed areas of loose skin, and loss of elastic fibers upon histopathologic examination. Two forms are traditionally distinguished, primary and secondary. Primary anetoderma occurs when there is no underlying associated skin disease, whereas the latter refers to an abnormal repair mechanism of preexisting skin lesions. Read More

Clin Exp Dermatol 2015 Aug 22;40(6):695-6. Epub 2015 Feb 22.

The Charles Centre for Dermatology, St Vincent's University Hospital, Dublin 4, Ireland.

Clin J Gastroenterol 2015 Feb 24;8(1):52-6. Epub 2015 Jan 24.

Department of Internal Diseases, Clinic of Gastroenterology, University Hospital "St.Marina", 1 Hristo Smirnenski Str., Varna, 9010, Bulgaria,

Background: Wilson's disease is an autosomal recessive disorder of copper homeostasis with predominantly hepatic and neuropsychiatric involvement. Anetoderma is a rare benign condition with focal damage of dermal elastic tissue. Previous reports described this skin disorder in association with prolonged D-Penicillamine therapy. Read More

Ann Chir Plast Esthet 2016 Feb 24;61(1):80-3. Epub 2014 Dec 24.

Service de chirurgie plastique, reconstructrice et esthétique, CHRU de Lille, hôpital Roger-Salengro, rue Emile-Laine, 59037 Lille, France.

Medaillon-like dermal dendrocyte hamartomas are rare congenital cutaneous lesions. They are present at birth as asymptomatic, benign, round, erythematous, well-circumscribed, atrophic patches. Typically, they have characteristic pliable, wrinkled surface; subtle telangiectases may also be appreciated. Read More

J Eur Acad Dermatol Venereol 2016 Jan 18;30(1):25-9. Epub 2014 Nov 18.

Department of Dermatology, Rabin Medical Center, Petach Tikva, Israel.

Background: Unilesional folliculotropic mycosis fungoides (UFMF) has been rarely reported.

Objective: The aim of this study was to describe our experience with UFMF.

Methods: Data were collected on all patients with clinicopathological UFMF who attended the Department of Dermatology of a tertiary university-affiliated medical centre in 1996-2013 and were followed prospectively. Read More

Case Rep Dermatol Med 2014 8;2014:781493. Epub 2014 Oct 8.

NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Via della Commenda 12, 20122 Milan, Italy.

Anetoderma is a skin disorder characterized by focal loss of elastic tissue in the mid dermis, resulting in localized areas of macular depressions or pouchlike herniations of skin. An iatrogenic form of anetoderma has been rarely described in extremely premature infants and has been related to the placement of monitoring devices on the patient skin. Because of the increasing survival of extremely premature infants, it is easy to foresee that the prevalence of anetoderma of prematurity will increase in the next future. Read More

Acta Derm Venereol 2015 Apr;95(4):499-500

Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

Ann Dermatol 2014 Oct 26;26(5):621-3. Epub 2014 Sep 26.

Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea.

Anetoderma is a rare cutaneous disorder characterized by a loss of normal elastic tissue that presents clinically as atrophic patches located mainly on the upper trunk. Recent studies suggest immunological mechanisms may play a role in this process. Furthermore, a secondary form of macular atrophy occurs in the course of infectious diseases (e. Read More

Am J Dermatopathol 2015 Jul;37(7):577-80

*Department of Dermatology, Saint Louis University, St. Louis, MO; and †Cutaneous Pathology, WCP Laboratories, Inc, St. Louis, MO.

Elastoderma is a rare cutaneous condition, which clinically presents as an acquired laxity and decreased recoil of skin. It is histologically characterized by an increase of pleomorphic and fragmented elastic fibers in the superficial dermis. A case of a 61-year-old woman with wrinkled lax skin on the anterior and lateral aspects of her neck was reported. Read More

Ann Dermatol 2014 Apr 30;26(2):283-5. Epub 2014 Apr 30.

Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.

J Dermatol 2014 Jun 19;41(6):552-3. Epub 2014 Apr 19.

UOC Dermatology, NESMOS Department, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.

Rev Med Interne 2014 Sep 4;35(9):624-5. Epub 2014 Feb 4.

Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.

Clin Exp Dermatol 2014 Mar 6;39(2):218-20. Epub 2013 Dec 6.

Department of Dermatology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.

Hautarzt 2014 Jan;65(1):59-62

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Deutschland,

The anetodermic ("bullous") subtype is a rare variant of pilomatricoma which we diagnosed in 2 girls who were 9 and 10 years old. The tumors presented as 3 × 2 and 1.5 × 1. Read More

J Clin Aesthet Dermatol 2013 Aug;6(8):23-8

Mount Sinai School of Medicine, Departments of Dermatology and Pathology, New York, New York.

Anetoderma is a rare, benign disorder characterized microscopically by the pan-dermal loss of elastic fibers in the dermis and presenting clinically as circumscribed, skin-colored or grey-white atrophic macules and/or patches on the trunk and/or extremities. Lesions are described as having a "sac-like" appearance, since they bulge or herniate upon palpation. Although the clinical picture is characteristic, a definitive diagnosis requires histological confirmation in order to differentiate this disorder from other conditions of elastolysis, such as cutis laxa and mid-dermal elastolysis. Read More

Am J Dermatopathol 2014 Feb;36(2):e19-21

Department of Pathology, Western General Hospital and the University of Edinburgh, Edinburgh, United Kingdom.

Molluscum contagiosum (MC) can rarely show follicular neogenesis as a result of proliferation of virus-infected basal cells. We report a case of molluscum contagiosum showing multifocal areas of primitive follicular induction involving the adjacent surface epidermis. The underlying dermis showed histological features suggestive of secondary anetoderma. Read More

Br J Dermatol 2013 Oct;169(4):869-79

Centenary Institute, Newtown, NSW, Australia; Discipline of Dermatology, University of Sydney, Camperdown, NSW, Australia; Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

Background: Multiphoton microscopy (MPM) is a novel imaging technology that has recently become applicable for diagnostic purposes. The use of (near) infrared light in MPM allows for deep tissue imaging. In addition, this modality exploits the autofluorescent nature of extracellular matrix fibres within the skin. Read More

J Am Acad Dermatol 2013 Sep 9;69(3):450-62. Epub 2013 Apr 9.

Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

Hypercoagulable states (HS) are inherited or acquired conditions that predispose an individual to venous and/or arterial thrombosis. The dermatologist can play a vital role in diagnosing a patient's HS by recognizing the associated cutaneous manifestations, such as purpura, purpura fulminans, livedo reticularis, livedo vasculopathy (atrophie blanche), anetoderma, chronic venous ulcers, and superficial venous thrombosis. The cutaneous manifestations of HS are generally nonspecific, but identification of an abnormal finding can warrant a further workup for an underlying thrombophilic disorder. Read More

Actas Dermosifiliogr 2014 Jan-Feb;105(1):99-101. Epub 2013 Mar 8.

Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.

Mycoses 2013 May 5;56(3):358-60. Epub 2013 Mar 5.

Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.

Dermatol Online J 2012 Dec 15;18(12):26. Epub 2012 Dec 15.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.

Anetoderma is an elastolytic disorder that is associated with a number of infectious and autoimmune disorders. We present a case of a patient with generalized anetoderma, who was later found to have positive antinuclear antibodies and antiphospholipid antibodies (APAs). Numerous other cases have been reported in literature and some authors have suggested that anetoderma is a highly specific sign of APAs, with or without other manifestations of systemic lupus erythematosus or antiphospholipid syndrome [14]. Read More

Pediatr Dermatol 2013 Jul-Aug;30(4):e68-9. Epub 2012 Sep 3.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

Pilomatricoma is a benign neoplasm originating from primitive cells of the hair matrix. Occasionally the skin overlying pilomatricomas assumes peculiar clinical features, and anetodermic change of the skin overlying pilomatricomas is sometimes seen, but perforation in pilomatricoma is a rare event. We report a case of perforating pilomatricoma with anetoderma in an adolescent with lymphoma. Read More

Dermatol Surg 2012 Oct 3;38(10):1741-3. Epub 2012 Aug 3.

Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Songpa-gu, Seoul, Korea.

Indian J Dermatol Venereol Leprol 2012 Jul-Aug;78(4):484-7

Skin Institute and School of Dermatology, N-Block, Greater Kailash-1, New Delhi-110048, India.

Pilomatricoma is an uncommon hamartomatous tumor of the hair matrix. Bullous and anetodermic changes over pilomatricoma are rare. We report an 18-year-old male with an asymptomatic nodule with overlying cystic changes on the left arm of 6-month duration with clinical and histological features of both bullous and anetodermic modifications. Read More

J Dermatol Case Rep 2012 Mar;6(1):14-7

Department of Dermatology, Andrology and S.T.Ds, Faculty of Medicine, Menoufiya University, Egypt.

Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon malignant mesenchymal tumor that arises in the dermis and is characterised by latency in its initial detection. As a rare form, atrophic or morphea-like DFSP has been documented. Atrophic DFSP resemble other benign lesions such as morphea, idiopathic atrophoderma, atrophic scar, anetoderma or lipoatrophy. Read More

J Cutan Med Surg 2012 Jan-Feb;16(1):64-7

Department of Dermatology and Pathology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Background: Anetoderma (focal loss of dermal elastic tissue) can either be primary, which is an idiopathic occurrence of anetoderma in normal areas of the skin, or secondary, which is preceded by an inflammatory dermatosis in the same location.

Objective: Sporadic reports of lupus erythematosus-associated anetoderma have been described in the literature. All reported cases were positive for antiphospholipid antibodies. Read More

Clin Exp Dermatol 2012 Aug 2;37(6):692-4. Epub 2012 Feb 2.

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

Dermatol Surg 2012 Apr 17;38(4):677-9. Epub 2012 Jan 17.

Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Int J Immunopathol Pharmacol 2011 Oct-Dec;24(4):1075-7

Anetoderma is a benign condition characterized by round or oval macular lesions with focal loss of dermal elastic tissue resulting in localized areas of flaccid or herniated saclike skin. Often, the anetoderma is associated with immuno-mediated pathogenetic mechanism. In this article, we describe the association between anetoderma and autoimmune diseases, by underlining the role and the action of macrophages as a possible etiopathogenesis. Read More

Rev Med Interne 2012 Apr 10;33(4):200-5. Epub 2011 Nov 10.

Service de dermatologie-allergologie, hôpital Tenon, université Paris-VI, 4, rue de la Chine, 75020 Paris, France.

A wide variety of dermatologic manifestations has been described in the antiphospholipid syndrome (APS). The most frequent skin lesion is livedo reticularis, present not only on the limbs but also on the trunk, with a fine irregular pattern. It belongs to the arterial subset of APS. Read More

Dermatol Online J 2011 Oct 15;17(10):12. Epub 2011 Oct 15.

Department of Dermatology, New York University, New York, New York, USA.

There are numerous acquired disorders of elastic tissue that are distinguished by a combination of clinical appearance, location, gender, age of onset, and characteristic histopathologic findings. We present a case of a 36-year-old man with multiple confluent, hypopigmented papules that coalesced into plaques with prominent follicular ostia over the dorsal aspects of the forearms, shoulders, upper chest, and upper back. Histologically there was selective loss of papillary dermal elastic fibers. Read More