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Am J Dermatopathol 2019 Feb;41(2):85-117

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

After a review of the physiology in the formation and degradation of cutaneous elastic tissue, we describe the clinicopathologic disorders characterized by increased and decreased cutaneous elastic tissue. Cutaneous disorders characterized by increased and/or abnormal elastic tissue in the dermis include elastoma, also named nevus elasticus, dermatosis lenticularis disseminata, pseudoxanthoma elasticum, late-onset focal dermal elastosis, linear focal elastosis, elastoderma, elastofibroma dorsi, and elastosis perforans serpiginosa. In some of these conditions, the specific histopathologic diagnosis may be rendered with hematoxylin-eosin stain, whereas in other ones special elastic tissue stains are necessary to demonstrate the anomalies. Read More

J Cutan Pathol 2019 Jan 11. Epub 2019 Jan 11.

Department of Dermatology, Philadelphia College of Osteopathic Medicine, Roswell, Georgia.

Medallion-like dermal dendrocyte hamartoma is a rare congenital lesion that is more commonly seen in females. It often presents at birth on the neck or upper trunk as a well-circumscribed, atrophic patch with wrinkling of the overlying skin. Clinically, the differential diagnosis includes atrophoderma, anetoderma, and congenital atrophic dermatofibrosarcoma protuberans. Read More

Acta Derm Venereol 2018 12 6. Epub 2018 Dec 6.

Department of Dermatology, Pontevedra University Hospital, EOXI Pontevedra-Salnés, Centro de Especialidades Mollavao, c/ Simón Bolívar s/n., ES-36001 Pontevedra, Spain.

J Dermatol 2018 Dec 15;45(12):1459-1462. Epub 2018 Oct 15.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Anetoderma is a rare cutaneous disorder characterized by focal loss of dermal elastic tissue, resulting in macular atrophy or herniated saclike skin. Some families with hereditary anetoderma have been described, but there have been no reports on Japanese familial anetoderma so far. We herein report two Japanese sibling cases of primary anetoderma. Read More

Ann Dermatol Venereol 2018 Dec 9;145(12):777-784. Epub 2018 Oct 9.

Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1 place de l'hôpital, 67091, Strasbourg, France.

Introduction: Impairment of dermal elastic tissue occurs in different entities associated with immunoglobulins or immunoglobulin-derived protein-secreting clonal plasma cell proliferations, such as amyloid elastosis, anetodermic nodular amyloidosis or monoclonal gammopathy-associated cutis laxa. We report a case of cutaneous immunoglobulinemic amyloidosis revealed by a unique chalazodermic presentation and we review elastic tissue impairment in patients with monoclonal gammopathies.

Observation: A 67-year-old woman consulted for non-infiltrated anetodermic lesions on the upper left quadrant of her abdomen present for ten years. Read More

J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1295

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetology, Saarland University Medical Center, Homburg, Germany.

With an incidence of 1 in 700 births, Down syndrome (DS) is not an uncommon condition. It is associated with various disorders of different organ systems. Serious disorders include cardiac defects and leukemia. Read More

Pediatr Dermatol 2018 Nov 28;35(6):e416-e417. Epub 2018 Aug 28.

Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, New York.

A 15-month-old boy presented with 1-4 cm, pink edematous plaques with overlying round erosions and hemorrhagic bullae in the setting of a gastrointestinal illness and was ultimately diagnosed with bullous-type Sweet syndrome. Despite appropriate treatment with oral steroids, the patient's cutaneous lesions healed with secondary anetoderma. This case should prompt practitioners to be aware of bullous-type Sweet syndrome and the possibility of lesions healing with postinflammatory scarring. Read More

Eur J Radiol 2018 Sep 21;106:92-99. Epub 2018 Jul 21.

Deptartment of Radiology, Institute of Surgery Research and Third Affilated Hospital, Army Medical University, Chongqing 400042, China. Electronic address:

Purpose: To describe the radiological characteristics of pilomatricomas on multi-detector computed tomography (MDCT) and magnetic resonance imaging (MRI), and to correlate the radiological findings and pathological features.

Materials And Methods: The radiological findings of 41 pilomatricomas in 31 patients were retrospectively reviewed. The images were evaluated with emphasis on calcifications, reticular and ring-like appearances, enhancement patterns, circular target sign and peritumoral fat stranding, and correlating these with pathological features. Read More

An Pediatr (Barc) 2019 Feb 13;90(2):126-127. Epub 2018 Apr 13.

Pediatría, Centro de Salud de San Sadurniño, SERGAS, San Sadurniño, A Coruña, España.

Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.

New York University Health, New York.

Anetoderma is a rare benign elastolytic disorder that is characterized by focal loss of elastin fibers on histopathology and is often recalcitrant to treatment. We present a case of a patient with a 20-year history of pruritic and painful hyperpigmented atrophic papules clustered on the neck, axillae, inframammary folds, and right medial thigh. Although the histopathologyof her axillary lesions was consistent with anetoderma, her clinical presentation is unusual given the extent of involvement, reported pain and pruritus, and sharp demarcation of the distribution. Read More

J Cutan Pathol 2017 Sep 5;44(9):786-789. Epub 2017 Jul 5.

Electron Microscopy, EMBRAPA-CPA-CT, Pelotas, Brazil.

Anetoderma is a rare cutaneous disorder characterized by focal loss of dermal elastic tissue due to unknown mechanisms. Primary anetoderma develops on clinical normal skin, without any preceding dermatosis and it can be associated with autoimmune conditions. Secondary anetoderma develops on the same area of a previous disorder, such as infectious, neoplastic or inflammatory diseases. Read More

Br J Dermatol 2017 06;176(6):e120

Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Int J STD AIDS 2017 12 1;28(14):1456-1460. Epub 2017 Jun 1.

4 Private Practice in São Paulo, São Paulo, Brazil.

Anetoderma is a rare benign condition of diverse etiology whose characteristic is the diminution or absence of the dermal elastic fibers. Classified as primary and secondary, the latter associated with tumors, inflammatory, and infectious diseases. Although the etiology of the lesions is well described in literature, the pathogenesis is still poorly determined. Read More

Br J Dermatol 2017 Oct 8;177(4):1127-1130. Epub 2017 Sep 8.

Dermatology Department, Nancy University Hospital, Vandoeuvre-les-Nancy, France.

Acrodermatitis chronica atrophicans (ACA) is the late cutaneous form of Lyme borreliosis. The early inflammatory phase manifests with a bluish-red discoloration and doughy swelling of the skin. The atrophic phase represents a late-phase process with red discoloration, and a thin and wrinkled appearance of the skin. Read More

Reumatol Clin 2018 Jul - Aug;14(4):242-243. Epub 2017 Mar 28.

Facultad de Medicina, Unidad de Patología Centro, Universidad de Chile, Las Condes, Santiago de Chile, Chile.

Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.

Hospital Universitario de Cabueñes, Servicio de Dermatología, Gijón, Asturias, España.

Pilomatricoma is a benign cutaneous tumor originatingfrom hair matrix cells. Anetodermic changes inthe skin overlying pilomatricomas are sometimesreported, although their precise mechanisms remainunknown. We present an unusual case of anetodermicpilomatricoma on the upper extremity of a 17-yearoldboy and report its clinical, histopathologic, andsonographic findings. Read More

Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.

Harvard Medical School, Boston, MA, USA. fandi_xia@ hms.harvard.edu.

Introduction: Anetoderma is an elastolytic skindisorder that has been associated with the presenceof antiphospholipid antibodies (aPL). Patients withantiphospholipid antibody-positive anetoderma havebeen reported to develop symptoms of Graves disease,antiphospholipid syndrome, and other autoimmuneconditions. The temporal relationship, however,between anetoderma onset and the emergence ofaPL remains unclear, a clarification of which may haveimplications for the screening and monitoring ofpatients with anetoderma. Read More

Clin Med (Lond) 2017 Feb;17(1):40-42

National University Health System, Singapore and Yong Loo Lin School of Medicine, National University Singapore, Singapore.

A 58-year-old Chinese woman with well controlled type 1 diabetes mellitus presented with acute and progressive bilateral lower limb weakness. Investigations revealed severe hypokalaemia (1.3 mmol/L) and hypophosphataemia (<0. Read More

J Immunol Res 2016 28;2016:4325463. Epub 2016 Dec 28.

Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

. The clinical and histopathologic classification of anetoderma are not well characterized. . Read More

G Ital Dermatol Venereol 2016 Oct;151(5):566-9

Department of Dermatology and Venereology, Ege University Faculty of Medicine, Izmir, Turkey -

JAMA Dermatol 2016 11;152(11):1239-1243

Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Importance: Infantile hemangiomas involute to some extent, but they often leave sequelae that may cause disfigurement. Factors determining the risk of permanent sequelae after regression are of crucial importance in treatment decision making.

Objectives: To describe the sequelae left by infantile hemangiomas after natural involution and to identify clinical characteristics that could predict the most severe or a particular type of sequelae. Read More

Zhonghua Zheng Xing Wai Ke Za Zhi 2016 May;32(3):166-70

Objective: To investigate a simple, minimally invasive and effective operative method for the facial rejuvenation in the upper eyelid and midface region.

Methods: Blepharoplasty was combined with suspending orbicularis oculi muscle flap and fixing it on the periosteum underneath the eyebrow through eyebrow incision. Meanwhile, for midface rejuvenation, inferior palpebral margin incision was performed and prezygomatic interspace was separated completely under the orbicularis oculi muscle. Read More

Indian J Lepr 2016 04;88(2):129-131

Elastophagocytosis is the engulfment of the elastic fibres by the histiocytes, multinucleated giant cells, or both. The cutaneous lesions showing elastophagocytosis are annular elastolytic giant cell granuloma, actinic keratoses, persistent insect-bite reactions, elastosis perforans serpiginosa, foreign body granuloma. Occasionally, it may occur in infectious diseases like leprosy, granulomatous syphilis, North-American blastomycosis, bacterial folliculitis, and cutaneous leishmaniasis. Read More

Med Clin (Barc) 2016 Oct 5;147(8):e47. Epub 2016 Mar 5.

Servicio de Dermatología, Hospital Universitario Doce de Octubre, Madrid, España.

Int J Dermatol 2016 Jul 5;55(7):739-44. Epub 2016 Mar 5.

Kempf und Pfaltz Histologische Diagnostik, Research Unit, Zurich, Switzerland.

Patients with a lymphoma have an increased risk of developing a second lymphoproliferative disorder. The association of nodal Hodgkin lymphoma and primary cutaneous marginal zone lymphoma (MALT type) is exceptional, and only very few cases have been documented. Anetoderma represents a circumscribed loss or rarefication of elastic fibers. Read More

Acta Derm Venereol 2016 08;96(6):828-9

Unit of Dermatology, University of Padua, Via C. Battisti 206, IT-35128 Padova, Italy.

Acta Derm Venereol 2016 06;96(5):708-10

Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Gudrunstr. 56, DE-44791 Bochum, Germany.

G Ital Dermatol Venereol 2016 Feb 18;151(1):130-1. Epub 2015 Nov 18.

Section of Dermatology and Venereology, Departmen of Surgery and Translational Medicine, P. Palagi Hospital, University of Florence, School of Health Sciences, Florence, Italy.

Ann Dermatol Venereol 2015 Nov 3;142(11):716-8. Epub 2015 Sep 3.

Service de dermatologie et vénéreologie, CHU Ibn Sina, université Mohammed V, 6, immeuble 60, résidence Al Boustane, Souissi, Rabat, Maroc.

Aesthetic Plast Surg 2015 Dec 26;39(6):968-70. Epub 2015 Aug 26.

Vascular Anomalies Program of Lenox Hill Hospital, 210 East 64th Street - 7th Floor, New York, NY, 10065, USA.

Unlabelled: I was asked to provide a commentary for "Shouldn't Propranolol be Used to Treat All Hemangiomas?" by Moodley et al. (Aesth Plast Surg, 2015. doi: 10. Read More

Am J Med Genet A 2015 Oct 8;167A(10):2459-62. Epub 2015 Jun 8.

Department of Dermatology, University of Iowa Hospitals and Clinics.

Terminal osseous dysplasia with pigmentary defects (TODPD) is a rare, X-linked syndrome classically characterized by distal limb anomalies, pigmented skin defects of the face, and recurrent digital fibromas. X-inactivation plays a major role in determining the range of phenotypic expression. Thus, patients can demonstrate a wide spectrum of disease severity, making accurate diagnosis more challenging. Read More

J Cosmet Laser Ther 2016 3;18(1):38-40. Epub 2015 Jul 3.

a Dermatology and Cutaneous Biology, Jefferson University Hospitals , Philadelphia , PA , USA.

Anetoderma is a skin disorder characterized by a focal loss of dermal elastic tissue whereby patients present with soft, depressible lesions. We postulated that a series of combination treatment using the 595-nm pulsed dye laser (PDL) and the 1550-nm non-ablative fractionated laser (NAFL) would improve the anetoderma lesions. Our patient with biopsy proven anetoderma received 3 treatments with a combination of 595-nm PDL and 1550-nm NAFL spaced 3 weeks apart. Read More

J Cutan Pathol 2015 Oct 4;42(10):765-8. Epub 2015 Jun 4.

Department of Dermatology and Dermatopathology, Cleveland Clinic, Cleveland, OH, USA.

Anetoderma is a cutaneous disorder characterized by loss of dermal elastic tissue resulting in papules from herniation of subcutaneous tissue or circumscribed areas of atrophic, wrinkled skin. Familial leiomyomatosis cutis et uteri (Reed syndrome) is an autosomal dominant disorder characterized by cutaneous and uterine leiomyomas. We report a 23-year-old male with Reed syndrome who presented with asymptomatic pearly white, atrophic, flaccid papules on the upper back and shoulder that depressed when palpated. Read More

Eur J Dermatol 2015 May-Jun;25(3):277-9

CHU Dupuytren, 2 Avenue Martin Luther King, 87042 Limoges, France.

Indian J Dermatol 2015 Mar-Apr;60(2):215

Department of Pathology, Subharti Medical College, Meerut, Uttar Pradesh, India.

Primary anetoderma is a rare idiopathic disease of the skin, characterized by circumscribed areas of loose skin, and loss of elastic fibers upon histopathologic examination. Two forms are traditionally distinguished, primary and secondary. Primary anetoderma occurs when there is no underlying associated skin disease, whereas the latter refers to an abnormal repair mechanism of preexisting skin lesions. Read More

Clin Exp Dermatol 2015 Aug 22;40(6):695-6. Epub 2015 Feb 22.

The Charles Centre for Dermatology, St Vincent's University Hospital, Dublin 4, Ireland.

Clin J Gastroenterol 2015 Feb 24;8(1):52-6. Epub 2015 Jan 24.

Department of Internal Diseases, Clinic of Gastroenterology, University Hospital "St.Marina", 1 Hristo Smirnenski Str., Varna, 9010, Bulgaria,

Background: Wilson's disease is an autosomal recessive disorder of copper homeostasis with predominantly hepatic and neuropsychiatric involvement. Anetoderma is a rare benign condition with focal damage of dermal elastic tissue. Previous reports described this skin disorder in association with prolonged D-Penicillamine therapy. Read More

Ann Chir Plast Esthet 2016 Feb 24;61(1):80-3. Epub 2014 Dec 24.

Service de chirurgie plastique, reconstructrice et esthétique, CHRU de Lille, hôpital Roger-Salengro, rue Emile-Laine, 59037 Lille, France.

Medaillon-like dermal dendrocyte hamartomas are rare congenital cutaneous lesions. They are present at birth as asymptomatic, benign, round, erythematous, well-circumscribed, atrophic patches. Typically, they have characteristic pliable, wrinkled surface; subtle telangiectases may also be appreciated. Read More

J Eur Acad Dermatol Venereol 2016 Jan 18;30(1):25-9. Epub 2014 Nov 18.

Department of Dermatology, Rabin Medical Center, Petach Tikva, Israel.

Background: Unilesional folliculotropic mycosis fungoides (UFMF) has been rarely reported.

Objective: The aim of this study was to describe our experience with UFMF.

Methods: Data were collected on all patients with clinicopathological UFMF who attended the Department of Dermatology of a tertiary university-affiliated medical centre in 1996-2013 and were followed prospectively. Read More

Case Rep Dermatol Med 2014 8;2014:781493. Epub 2014 Oct 8.

NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Via della Commenda 12, 20122 Milan, Italy.

Anetoderma is a skin disorder characterized by focal loss of elastic tissue in the mid dermis, resulting in localized areas of macular depressions or pouchlike herniations of skin. An iatrogenic form of anetoderma has been rarely described in extremely premature infants and has been related to the placement of monitoring devices on the patient skin. Because of the increasing survival of extremely premature infants, it is easy to foresee that the prevalence of anetoderma of prematurity will increase in the next future. Read More

Acta Derm Venereol 2015 Apr;95(4):499-500

Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

Ann Dermatol 2014 Oct 26;26(5):621-3. Epub 2014 Sep 26.

Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea.

Anetoderma is a rare cutaneous disorder characterized by a loss of normal elastic tissue that presents clinically as atrophic patches located mainly on the upper trunk. Recent studies suggest immunological mechanisms may play a role in this process. Furthermore, a secondary form of macular atrophy occurs in the course of infectious diseases (e. Read More

Am J Dermatopathol 2015 Jul;37(7):577-80

*Department of Dermatology, Saint Louis University, St. Louis, MO; and †Cutaneous Pathology, WCP Laboratories, Inc, St. Louis, MO.

Elastoderma is a rare cutaneous condition, which clinically presents as an acquired laxity and decreased recoil of skin. It is histologically characterized by an increase of pleomorphic and fragmented elastic fibers in the superficial dermis. A case of a 61-year-old woman with wrinkled lax skin on the anterior and lateral aspects of her neck was reported. Read More

Ann Dermatol 2014 Apr 30;26(2):283-5. Epub 2014 Apr 30.

Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.

J Dermatol 2014 Jun 19;41(6):552-3. Epub 2014 Apr 19.

UOC Dermatology, NESMOS Department, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.

Rev Med Interne 2014 Sep 4;35(9):624-5. Epub 2014 Feb 4.

Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.

Clin Exp Dermatol 2014 Mar 6;39(2):218-20. Epub 2013 Dec 6.

Department of Dermatology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.

Hautarzt 2014 Jan;65(1):59-62

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Deutschland,

The anetodermic ("bullous") subtype is a rare variant of pilomatricoma which we diagnosed in 2 girls who were 9 and 10 years old. The tumors presented as 3 × 2 and 1.5 × 1. Read More

J Clin Aesthet Dermatol 2013 Aug;6(8):23-8

Mount Sinai School of Medicine, Departments of Dermatology and Pathology, New York, New York.

Anetoderma is a rare, benign disorder characterized microscopically by the pan-dermal loss of elastic fibers in the dermis and presenting clinically as circumscribed, skin-colored or grey-white atrophic macules and/or patches on the trunk and/or extremities. Lesions are described as having a "sac-like" appearance, since they bulge or herniate upon palpation. Although the clinical picture is characteristic, a definitive diagnosis requires histological confirmation in order to differentiate this disorder from other conditions of elastolysis, such as cutis laxa and mid-dermal elastolysis. Read More

Am J Dermatopathol 2014 Feb;36(2):e19-21

Department of Pathology, Western General Hospital and the University of Edinburgh, Edinburgh, United Kingdom.

Molluscum contagiosum (MC) can rarely show follicular neogenesis as a result of proliferation of virus-infected basal cells. We report a case of molluscum contagiosum showing multifocal areas of primitive follicular induction involving the adjacent surface epidermis. The underlying dermis showed histological features suggestive of secondary anetoderma. Read More