192,695 results match your criteria Anesthesiology Research and Practice [Journal]


MicroRNA-128 Protects Dopamine Neurons from Apoptosis and Upregulates the Expression of Excitatory Amino Acid Transporter 4 in Parkinson's Disease by Binding to AXIN1.

Cell Physiol Biochem 2018 7;51(5):2275-2289. Epub 2018 Dec 7.

Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming,

Background/aims: Parkinson's disease (PD) is a frequently occurring condition that resulted from the loss of midbrain neurons, which synthesize the neurotransmitter dopamine. In this study, we established mouse models of PD to investigate the expression of microRNA-128 (miR-128) and mechanism through which it affects apoptosis of dopamine (DA) neurons and the expression of excitatory amino acid transporter 4 (EAAT4) via binding to axis inhibition protein 1 (AXIN1).

Methods: Gene expression microarray analysis was performed to screen differentially expressed miRNAs that are associated with PD. Read More

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December 2018
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Genes known to escape X chromosome inactivation predict co-morbid chronic musculoskeletal pain and posttraumatic stress symptom development in women following trauma exposure.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 11. Epub 2018 Dec 11.

Institute for Trauma Recovery, University of North Carolina, Chapel Hill, North Carolina.

Co-morbid chronic musculoskeletal pain (CMSP) and posttraumatic stress symptoms (PTSS) are frequent sequelae of motor vehicle collision, are associated with greater disability than either outcome alone, and are more prevalent in women than men. In the current study we assessed for evidence that gene transcripts originating from the X chromosome contribute to sex differences in vulnerability to CMSP and PTSS after motor vehicle collision. Nested samples were drawn from a longitudinal study of African American individuals, and CMSP (0-10 numeric rating scale) and PTSS (impact of events scale, revised) outcomes were assessed 6 months following motor vehicle collision. Read More

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December 2018
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Markers of Accelerated Skeletal Muscle Regenerative Response in MRL/MpJ Mice: Characteristics of Muscle Progenitor Cells and Circulating Factors.

Stem Cells 2018 Dec 10. Epub 2018 Dec 10.

Department of Orthopaedic Surgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

The "super-healing" Murphy Roths Large (MRL/MpJ) mouse possesses a superior regenerative capacity for repair of many tissues, which makes it an excellent animal model for studying molecular and cellular mechanisms during tissue regeneration. Since the role of muscle progenitor cells (MPCs) in muscle healing capacity of MRL/MpJ mice has not been previously studied, we investigated the muscle regenerative capacity of MRL/MpJ mice following muscle injury, and the results were compared to results from C57BL/6 J (B6) age-matched control mice. Our results show that muscle healing upon cardiotoxin injury was accelerated in MRL/MpJ mice and characterized by reduced necrotic muscle area, reduced macrophage infiltration, and more regenerated myofibers (eMyHC+/centronucleated fibers) at 3, 5, and 12 days post-injury, when compared to B6 age-matched control mice. Read More

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December 2018

Correlation of plasma coagulation tests and fibrinogen with rotational thromboelastometry parameters and prediction of bleeding in dogs.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department for Small Animals, Critical Care Unit, University of Zurich, Zurich, Switzerland.

Background: Correlation of plasma fibrinogen concentration (fibrinogen ) with rotational thromboelastometry (ROTEM) parameters has not been investigated in dogs.

Objectives: To determine the correlation between plasma coagulation tests and fibrinogen with ROTEM parameters and to evaluate their ability to predict bleeding in dogs.

Animals: Ninety-seven dogs with concurrent determination of fibrinogen and fibrin polymerization test (FIBTEM) analysis. Read More

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December 2018

Persistence of a pacemaker lead-like "ghost" 6 months after lead extraction.

Echocardiography 2018 Dec 9. Epub 2018 Dec 9.

Rajaie Cardiovascular Medical & Research Center, Tehran, Iran.

Residual fibrous structures, referred as "ghosts", are occasionally encountered following lead extraction. Though typically detected in patients with cardiac device infections, their prognostic and therapeutic implications remain speculative. We describe a 62-year-old gentleman with history of sick sinus syndrome who presented atrial fibrillation with rapid ventricular response. Read More

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December 2018

Integrative analysis of DNA methylation and gene expression identify a six epigenetic driver signature for predicting prognosis in hepatocellular carcinoma.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

DNA methylation is a crucial regulator of gene transcription in the etiology and pathogenesis of hepatocellular carcinoma (HCC). Thus, it is reasonable to identify DNA methylation-related prognostic markers. Currently, we aimed to make an integrative epigenetic analysis of HCC to identify the effectiveness of epigenetic drivers in predicting prognosis for HCC patients. Read More

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December 2018

Propofol partially attenuates complete freund's adjuvant-induced neuroinflammation through inhibition of the ERK1/2/NF-κB pathway.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Anesthesiology, Quzhou Hospital of Zhejiang University School of Medicine, Quzhou, China.

Peripheral inflammation in male C57BL/6 mice was induced by intraplantar injection of 20 μL complete freund's adjuvant (CFA) in the left hind paw. Mice were randomly divided into three groups: Sham, CFA, and propofol+CFA. Mechanical allodynia was assessed by von Frey analysis, and heat hyperalgesia was detected by exposure of the plantar surface to a beam of radiant heat. Read More

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December 2018

Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop.

J Am Geriatr Soc 2018 Dec 7. Epub 2018 Dec 7.

Cardiovascular Division, Department of Internal Medicine, Washington University, St. Louis, Missouri.

Objectives: To identify the top priority areas for research to optimize pharmacotherapy in older adults with cardiovascular disease (CVD).

Design: Consensus meeting.

Setting: Multidisciplinary workshop supported by the National Institute on Aging, the American College of Cardiology, and the American Geriatrics Society, February 6-7, 2017. Read More

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December 2018

Intrathecal betamethasone for cancer pain: A study of its analgesic efficacy and safety.

Acta Anaesthesiol Scand 2018 Dec 7. Epub 2018 Dec 7.

Department of Anesthesiology, Kansai Medical University Medical Center, Moriguchi, Japan.

Background: A preliminary study has shown effective cancer pain relief by intrathecal betamethasone (ITB). However, further evidence is needed to support this new approach.

Methods: Cancer patients with opioid-resistant pain received lumbar intrathecal administration of betamethasone 2 or 3 mg once a week for 28 days. Read More

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December 2018
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Perioperative Antithrombotic Therapy Does Not Increase the Incidence of Early Postoperative Thromboembolic Complications and Bleeding in Kidney Transplantation. - a retrospective study.

Transpl Int 2018 Dec 10. Epub 2018 Dec 10.

Division of Transplantation Surgery, Department of Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.

Perioperative antithrombotic therapy could play a role in preventing thromboembolic complications (TEC) after kidney transplantation (KTx), but little is known on postoperative bleeding risks. This retrospective analysis comprises 2000 single-organ KTx recipients transplanted between 2011-2016 in the two largest transplant centers of the Netherlands. TEC and bleeding events were scored ≤7 days post-KTx. Read More

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December 2018

Neurologic recovery after deep hypothermic circulatory arrest in rats: A description of a long-term survival model without blood priming.

Artif Organs 2018 Dec 8. Epub 2018 Dec 8.

Department of Cardiopulmonary Bypass, State key laboratory of Cardiovascular Medicine, Fuwai Hospital, National center for Cardiovascular disease, Chinese Academy of Medical science and Peking Union Medical College, Beijing, China.

Brain injury associated with deep hypothermic circulatory arrest (DHCA) has been recognized in patients with congenital heart diseases and those undergoing aortic arch surgeries. However, the preclinical investigation of long-term cerebral injury and recovery mechanisms related to DHCA has been restricted to a satisfactory recovery animal model with a determined recovery time. This study aimed to evaluate the feasibility of a long-term surviving DHCA model without blood priming in rats, in order to investigate the pathophysiology of long-term complications in further studies. Read More

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December 2018

Incidence of severe critical events in paediatric anaesthesia in the United Kingdom: secondary analysis of the anaesthesia practice in children observational trial (APRICOT study).

Anaesthesia 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatric Anaesthesia and Pain Management, University of Glasgow, Glasgow, Scotland, UK.

The anaesthesia practice in children observational trial of 31,127 patients in 261 European hospitals revealed a high (5.2%) incidence of severe critical events in the peri-operative period and wide variability in practice. A sub-analysis of the UK data was undertaken to investigate differences compared with the non-UK cohort in the incidence and nature of peri-operative severe critical events and to attempt to identify areas for quality improvement. Read More

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December 2018

Histamine H3 receptor antagonist Clobenpropit protects propofol-induced apoptosis of hippocampal neurons through PI3K/AKT pathway.

Authors:
W He Q-H Yuan Q Zhou

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8013-8020

Department of Anaesthesiology, Mianyang Central Hospital, Mianyang, China.

Objective: The aim of the study was to explore whether histamine H3 receptor antagonist Clobenpropit could protect propofol-induced neurotoxicity in hippocampal neurons.

Materials And Methods: Hippocampal neurons were extracted from neonatal rats and induced with propofol. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay was performed to detect apoptotic rate of neurons. Read More

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November 2018

Spontaneous pulmonary air embolism in a child undergoing procedural deep sedation: case report and review of the literature.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7916-7919

Department of Anesthesiology and Intensive Care, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

We performed a systematic review of the literature starting from a real case of venous air embolism (VAE) in a young infant undergoing central catheterization during procedural sedation. Air embolism due to internal jugular vein catheterization during procedural sedation is very rare, but it is a potentially life-threatening complication of central catheterization that warrants attention. To our knowledge, this is the first case published in a similar scenario. Read More

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November 2018

Refractory Severe Thrombocytopenia during Pregnancy: How to Manage.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):803-807. Epub 2018 Dec 7.

Department of Anaesthesiology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Thrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. Read More

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December 2018

Inflammasome in the Pathogenesis of Pulmonary Diseases.

Exp Suppl 2018 ;108:111-151

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, USA.

Lung diseases are common and significant causes of illness and death around the world. Inflammasomes have emerged as an important regulator of lung diseases. The important role of IL-1 beta and IL-18 in the inflammatory response of many lung diseases has been elucidated. Read More

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January 2018

A retrospective evaluation of the risk of bias in perioperative temperature metrics.

J Clin Monit Comput 2018 Dec 8. Epub 2018 Dec 8.

Department of Anesthesiology, Vanderbilt University Medical Center, 1211 21st Avenue South, MAB 422F, Nashville, TN, 37212, USA.

The prevention and treatment of hypothermia is an important part of routine anesthesia care. Avoidance of perioperative hypothermia was introduced as a quality metric in 2010. We sought to assess the integrity of the perioperative hypothermia metric in routine care at a single large center. Read More

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December 2018
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Clinicopathologic Characteristics and Prognosis Analysis of Marjolin's Ulcer in 40 Cases.

Curr Med Sci 2018 Dec 7;38(6):1038-1044. Epub 2018 Dec 7.

Department of Plastic Surgery, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Marjolin's ulcer (MU) is a rare but aggressive epidermoid carcinoma observed in scars or wounds. This article provides comprehensive characteristics and prognostic details of MU. Clinical data of 40 patients with MU between January 2010 and December 2017 were analyzed retrospectively. Read More

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December 2018
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Relationship between Volatile Anesthetics and Tumor Progression: Unveiling the Mystery.

Curr Med Sci 2018 Dec 7;38(6):962-967. Epub 2018 Dec 7.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

A series of factors can be involved in the perioperative period to cause an increase in cancer-related mortality. Unfortunately, volatile anesthesia might aggravate the deleterious effects. In this article, we review the association of diverse volatile anesthetic agents with immune system and cancer cell biology, and examine the effects on angeogenesis and postoperative metastasis or recurrence. Read More

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December 2018

Additional benefit of local infiltration of analgesia to femoral nerve block in total knee arthroplasty: double-blind randomized control study.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 8. Epub 2018 Dec 8.

Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, 185-1 Oko-cho Kohasu, Nankoku, 783-8505, Japan.

Purpose: Multimodal analgesia has become an important concept in current pain management following total knee arthroplasty (TKA). However, controversy remains over what is the most accepted combination. In this study, the additional benefits of local infiltration of analgesia to femoral nerve block were evaluated. Read More

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December 2018

The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study.

Int Urogynecol J 2018 Dec 10. Epub 2018 Dec 10.

Department of General Gynecology and Gynecologic Oncology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Introduction And Hypothesis: Abnormalities of connective tissue structure or its repair mechanism may predispose women to pelvic organ prolapse (POP). We hypothesized that the expression of tenascin-X in the uterosacral ligament of postmenopausal women with symptomatic POP is increased compared with postmenopausal women without POP. Furthermore, we identified clinical risk factors associated with POP in our study population. Read More

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December 2018

The application of nasoseptal "rescue" flap technique in endoscopic transsphenoidal pituitary adenoma resection.

Neurosurg Rev 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurosurgery, Qilu Hospital, Shandong University, 107 Wenhua Western Rd., Jinan, 250012, Shandong, China.

To explore the reliability and superiority of nasoseptal "rescue" flap technique in neuroendoscopic transnasal pituitary adenoma resection. Retrospective clinical analysis of 113 cases of endoscopic transsphenoid pituitary adenoma resection with the application of nasoseptal "rescue" flap technology. The reliability and the superiority of the technique were evaluated according to the duration of nasal cavity and sphenoid sinus stage, the incidence of postoperative anosmia, and cerebrospinal rhinorrhea. Read More

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December 2018

Effects of crystalloids and colloids on microcirculation, central venous oxygen saturation, and central venous-to-arterial carbon dioxide gap in a rabbit model of hemorrhagic shock.

J Anesth 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiovascular Surgery, Tokyo Women's Medical University, 8-1, Kawadacho Shinjuku-ku, Tokyo, 162-8666, Japan.

Objective: The effects of hydroxyethyl starch (HES) on microcirculation, central venous oxygen saturation (ScvO), and the central venous-to-arterial carbon dioxide gap (dCO) are studied in a rabbit model of hemorrhagic shock for elucidating the advantages and drawbacks of resuscitation with HES compared with crystalloids.

Methods: An ear chamber and sublingual mucosa were used to examine blood vessels by intravital microscopy. Hemorrhagic shock was induced by removing nearly half of the blood volume. Read More

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December 2018

Age-associated hippocampal volume changes in childhood arterial ischemic stroke.

Childs Nerv Syst 2018 Dec 8. Epub 2018 Dec 8.

Department of Radiology, Children's Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.

Purpose: Recent evidence suggests that recovery from secondary neurodegeneration following arterial ischemic stroke (AIS) may be related to age at injury and site of occlusion. We conducted a study of hippocampal volume (HCV) in a cohort of pediatric patients with middle cerebral artery (MCA) territory AIS to determine whether HCV would be preserved in younger children as compared to older children.

Methods: This single-center, HIPAA-compliant retrospective study was approved by the institutional review board. Read More

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December 2018

Impact of individualized target mean arterial pressure for septic shock resuscitation on the incidence of acute kidney injury: a retrospective cohort study.

Ann Intensive Care 2018 Dec 10;8(1):124. Epub 2018 Dec 10.

Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background: To examine the relationship between delta mean arterial pressure (ΔMAP; MAP change between pre-admission minus post-resuscitation) and acute kidney injury (AKI) among patients with septic shock. In this retrospective, single-center cohort study of adult patients pre-admission MAP is defined as the median MAP recorded from 365 to 7 days before admission. Post-resuscitation MAP was median MAP during the 7th hour after initiating resuscitation. Read More

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December 2018
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Ultrasound-Guided Bilateral Erector Spinae Block Versus Tumescent Anesthesia for Postoperative Analgesia in Patients Undergoing Reduction Mammoplasty: A Randomized Controlled Study.

Aesthetic Plast Surg 2018 Dec 10. Epub 2018 Dec 10.

Anesthesiology and Reanimation, Kahramanmaraş Sutcu Imam University School of Medicine, Kahramanmaras, Turkey.

Purpose: The aim of this prospective, randomized, double-blind study was to compare the tumescent anesthesia method and erector spinae block with respect to postoperative analgesia consumption, pain scores and patient satisfaction, in patients receiving breast reduction surgery under general anesthesia.

Methods: The study included 44 females, aged 20-65 years, who were to undergo breast reduction surgery, without adjunctive liposuction on the breast. Using the closed envelope method, the patients were randomly separated into two groups to receive tumescent anesthesia or erector spinae block (ESB). Read More

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December 2018

Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis.

Oncol Rep 2018 Nov 28. Epub 2018 Nov 28.

Department of Anesthesiology, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

Resveratrol is a type of polyphenol that is abundantly present in knotweed and grapes, and has been confirmed to have tumor‑inhibitory properties. However, the effect of resveratrol on tumor cells under chronic stress conditions remains unclear. The aim of the present study was to demonstrate that resveratrol exerts a significant inhibitory effect on the growth and proliferation of tumor cells under chronic stress in a dose‑dependent manner. Read More

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November 2018

Third Molar Extraction and Persistent Use of Opioids-Reply.

JAMA 2018 Dec;320(22):2377-2378

University of Michigan School of Dentistry, Ann Arbor.

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December 2018

Discontinuation of dual antiplatelet therapy and bleeding in intensive care in patients undergoing urgent coronary artery bypass grafting: a retrospective analysis.

Interact Cardiovasc Thorac Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Anaesthesiology and Surgical Intensive Care, University Hospital Basel, Basel, Switzerland.

Objectives: Our goal was to evaluate the impact of the discontinuation times of dual antiplatelet therapy with clopidogrel, prasugrel or ticagrelor on postoperative bleeding rates and the use of blood products in patients undergoing isolated urgent coronary artery bypass grafting (CABG).

Methods: We retrospectively analysed 334 patients with acute coronary syndrome undergoing urgent CABG at the University Hospital Basel. A total of 262 patients continued to take dual antiplatelet therapy during the surgery (72 received clopidogrel; 68, prasugrel; and 122, ticagrelor). Read More

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December 2018

Pharmacokinetic evaluation of linezolid administered intravenously in obese patients with pneumonia.

J Antimicrob Chemother 2018 Dec 7. Epub 2018 Dec 7.

Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, Ghent, Belgium.

Objectives: Altered linezolid pharmacokinetics (PK) in obese individuals has been hypothesized in previous studies. However, specific dosing recommendations for this population are still lacking. The main goal of this study was to evaluate PK/pharmacodynamic (PKPD) target attainment when using a 600 mg intravenous q12h linezolid dose against MRSA in obese patients with pneumonia. Read More

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December 2018

Advance care planning for patients with cancer in the palliative phase in Dutch general practices.

Fam Pract 2018 Dec 10. Epub 2018 Dec 10.

Department of Primary and Community Care, Radboud University Medical Centre, Nijmegen, The Netherlands.

Background: Advance care planning (ACP) is a crucial element of palliative care. It improves the quality of end-of-life care and reduces aggressive and needless life-prolonging medical interventions. However, little is known about its application in daily practice. Read More

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December 2018

Vidian Neurectomy for Management of Chronic Cluster Headache.

Neurosurgery 2018 Dec 10. Epub 2018 Dec 10.

School of Medicine, Tzu Chi University, Hualien, Taiwan, Republic of China.

Background: Management of chronic cluster headache (CCH) remains a challenging endeavor, and the optimal surgical approach for medically refractory CCH remains controversial.

Objective: To conduct a preliminary evaluation of the efficacy and safety of vidian neurectomy (VN) in patients with medically refractory CCH.

Methods: Between March 2013 and December 2015, 9 CCH patients, all of whom had failed to respond to conservative therapy, underwent VN with a precise nerve cut and maximal preservation of the sphenopalatine ganglion. Read More

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December 2018

Significant parameters in the evaluation of donor lungs in single-lung cellular ex vivo lung perfusion.

Interact Cardiovasc Thorac Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Objectives: Typically, single-lung ex vivo lung perfusion (SL-EVLP) is preferred when there is concern of contamination from the opposite lung. However, a comprehensive assessment of the SL-EVLP has not been completed. The purpose of this study is to compare the physiological parameters of SL-EVLP and double-lung EVLP (DL-EVLP) in the assessment of transplant suitability. Read More

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December 2018

Placental findings in pregnancies complicated with IUGR - histopathological and immunohistochemical analysis.

Rom J Morphol Embryol 2018 ;59(3):715-720

Department of Anesthesiology and Intensive Care, University of Medicine and Pharmacy of Craiova, Romania; Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, Romania;

Objective: Placental lesions and placental ischemia are typical elements of intrauterine growth restriction (IUGR). The aim of this study is to analyze histological and immunohistochemical (IHC) changes in the placentas of IUGR fetuses.

Materials And Methods: In this prospective study, 126 placentas from small for gestational age (SGA) pregnancies (newborns with birth weight <10th percentile) that formed the study group and 31 placentas from pregnancies without SGA representing control group, were included. Read More

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January 2018

Clinical, histological and therapeutic modern approach of Ledderhose disease.

Rom J Morphol Embryol 2018 ;59(3):691-697

Department of Anesthesiology and Intensive Care, Emergency Clinical Hospital of Bucharest, Romania;

Ledderhose disease or plantar fibromatosis is a rare hyperproliferative disorder of the plantar aponeurosis, clinically characterized by nodules situated especially on the medial border of the foot. It is histopathologically associated with Dupuytren's disease. This disease has some risk factors, like old age, alcohol or nicotine abuse, liver dysfunction, trauma or exposure to vibrations and autoimmune disorders, but the exact etiology is still unknown. Read More

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January 2018

Heme oxygenase-1 inducer and carbon monoxide-releasing molecule enhance the effects of gabapentinoids by modulating glial activation during neuropathic pain in mice.

Pain Rep 2018 Sep-Oct;3(5):e677. Epub 2018 Aug 6.

Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Introduction: Neuropathic pain is one of the most difficult-to-treat symptoms. Although gabapentinoids are classified as first-line drugs, they have only modest efficacy.

Objectives: The aim of this study was to investigate whether treatment with the heme oxygenase-1 (HO-1) inducer cobalt protoporphyrin IX (CoPP) or the carbon monoxide-releasing molecule tricarbonyldichlororuthenium (II) dimer (CORM-2) can enhance the antinociceptive effects produced by gabapentinoids in mice with neuropathic pain. Read More

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Hypercoagulability in End-stage Liver Disease: Review of Epidemiology, Etiology, and Management.

Transplant Direct 2018 Nov 26;4(11):e403. Epub 2018 Oct 26.

Department of Anesthesiology and Perioperative Medicine, The Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA.

In this review, we analyze the epidemiology of thromboses related to end-stage liver disease (ESLD), discuss causes of hypercoagulability, describe susceptible populations, and critically evaluate proposed prophylaxis and treatment of thromboses. Classically, ESLD has been regarded as a model for coagulopathy, and patients were deemed to be at high risk for bleeding complications. Patients with ESLD are not auto-anticoagulated, and they do not have a lower risk of portal vein thrombosis, intracardiac thrombus formation, pulmonary embolism or hepatic artery thrombosis. Read More

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November 2018

Characterizing post-extubation negative pressure pulmonary edema in the operating room-a retrospective matched case-control study.

Perioper Med (Lond) 2018 6;7:28. Epub 2018 Dec 6.

1Department of Anesthesiology, E-Da Hospital/E-Da Cancer Hospital, I-Shou University, No 1, Yida Road. Yanchao Dist., Kaohsiung city, 824 Taiwan.

Background: Post-extubation negative pressure pulmonary edema (NPPE) is an uncommon but important anesthesia-related emergency presenting with acute respiratory distress and hypoxemia after removal of airway devices. This study investigated the incidence and associated risk factors for post-extubation NPPE during emergence.

Methods: This retrospective, matched case-control study was conducted by reviewing the post-anesthesia records in Tzu Chi General Hospital, Taiwan. Read More

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December 2018

Comparison of nitrous oxide/midazolam and nitrous oxide/promethazine for pediatric dental sedation: A randomized, cross-over, clinical trial.

Dent Res J (Isfahan) 2018 Nov-Dec;15(6):411-419

Department of Pediatric Dentistry, Dental School, Shahed University, Tehran, Iran.

Background: This study compared the safety and efficacy of nitrous oxide (NO)/midazolam and NO/promethazine for dental treatment of uncooperative children.

Materials And Methods: In this randomized, cross-over, clinical trial investigation Eighteen healthy uncooperative children with a pair of similar teeth requiring the same treatment were included. Combination of NO/midazolam was given in one visit, where NO/promethazine was administrated in the other appointment for each patient in a cross-over manner. Read More

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December 2018

Effects of Intraoperative Dexamethasone and Ondansetron on Postoperative Nausea and Vomiting in Microvascular Decompression Surgery: A Randomized Controlled Study.

Anesthesiol Res Pract 2018 11;2018:6297362. Epub 2018 Nov 11.

Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: Postoperative nausea and vomiting (PONV) is a common problem and may lead to catastrophic complications, especially in neurosurgical cases. The aim of this study was to evaluate the effects of dexamethasone and ondansetron for preventing PONV in patients who underwent microvascular decompression (MVD) surgery.

Methods: A prospective, double-blinded, randomized control trial was conducted with 54 patients who underwent MVD. Read More

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November 2018

Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia.

Front Physiol 2018 26;9:1647. Epub 2018 Nov 26.

Laboratory of Translational Research "Stress and Immunity", Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.

The Antarctic continent is an environment of extreme conditions. Only few research stations exist that are occupied throughout the year. The German station Neumayer III and the French-Italian Concordia station are such research platforms and human outposts. Read More

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November 2018

Diagnostic Utility of Serum Neutrophil Gelatinase-Associated Lipocalin in Polytraumatized Patients Suffering Acute Kidney Injury: A Prospective Study.

Biomed Res Int 2018 6;2018:2687584. Epub 2018 Nov 6.

Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Austria.

Introduction: The incidence of acute kidney injury (AKI) considerably increases the mortality rate in polytrauma victims. Undoubtedly, early identification of patients at risk is crucial for timely implementation of preventive strategies in order to improve their prognosis. Therefore, we aimed to investigate if serum neutrophil gelatinase-associated lipocalin (sNGAL) may serve as a diagnostic biomarker of early AKI in polytrauma victims, especially considering patients needing renal replacement theory (RRT). Read More

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November 2018

Comparison Between Lidocaine Inhalation and Intravenous Dexamethasone in Reducing Postoperative Sore Throat Frequency After Laryngeal Mask Insertion.

Anesth Pain Med 2018 Oct 25;8(5):e82131. Epub 2018 Aug 25.

Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia.

Background: The frequency of postoperative sore throat (POST) after laryngeal mask airway insertion (LMA) was relatively high. Lidocaine might reduce the pain and inflammatory response. Additionally, inhalation form might result in a better distribution, which results in a better airway analgesia and minimal systemic effect. Read More

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October 2018

Comparison of the Effect of Bupivacaine in Combination with Dexmedetomidine with Bupivacaine Plus Placebo on Neonatal Apgar Score, Bispectral Index, and Sedation Level of Parturient Women.

Anesth Pain Med 2018 Oct 24;8(5):e81947. Epub 2018 Oct 24.

Department of Anesthesiology and Critical Care, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: In this study, we aimed to compare the effects of bupivacaine alone and in combination with dexmedetomidine on postoperative analgesia, neonatal Apgar score, and bispectral index (BIS), which has been shown to correlate with increased sedation and loss of consciousness in women undergoing cesarean section under spinal anesthesia.

Methods: A total of 152 term parturient women scheduled to have elective cesarean section with American Society of Anesthesiologist (ASA) physical status I or II were allocated randomly into two groups to receive either bupivacaine plus placebo (BV group) or bupivacaine plus dexmedetomidine (BVD group). BIS, sedation scale scores, Apgar scores, and hemodynamic characteristics were recorded and statistically compared between the groups. Read More

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October 2018

The Obv-Eas Method: An Easy Way to Facilitate Fiberoptic Intubation in Pediatric Patients: Case of an Infant with Freeman-Sheldon Syndrome.

Anesth Pain Med 2018 Oct 18;8(5):e81451. Epub 2018 Sep 18.

Orthopedics Surgery, Selcuk University Medical Faculty, Konya, Turkey.

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October 2018

Comparison of Three-Quadrant Transversus Abdominis Plane Block and Continuous Epidural Block for Postoperative Analgesia After Transperitoneal Laparoscopic Nephrectomy.

Anesth Pain Med 2018 Oct 3;8(5):e80024. Epub 2018 Sep 3.

Department of Anesthesiology and Intensive Care, Universitas Indonesia, Jakarta, Indonesia.

Background: Postoperative pain management is important for the early recovery of the living donor patient. Patient-controlled opioid analgesia, epidural analgesia, or a combination of both is the preferred pain management after abdominal surgery although these approaches have serious side effects. The transversus abdominis plane (TAP) block has been increasingly used for postoperative pain management and the addition of dexamethasone to local anesthetic can prolong the duration of action. Read More

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October 2018

The Comparison of the Effect of Mannitol and N Acetyl Cysteine on Liver Function in Partial Hepatectomy.

Anesth Pain Med 2018 Oct 22;8(5):e79677. Epub 2018 Sep 22.

Department of Surgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

The alterations in liver function in patients after major liver resection are complex. Partial hepatectomy surgery is considered as a selective therapeutic approach in many benign and malignant liver tumors, secondary metastases, and liver trauma. According to surgical techniques most often based on vascular control and hepatic venous closure (Pringle maneuver), related complications such as ischemia and decreased venous return during and after surgery can be seen. Read More

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October 2018

The Effect of Preoperative Zintoma Capsule on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy.

Anesth Pain Med 2018 Oct 27;8(5):e67132. Epub 2018 Oct 27.

Department of Anesthesiology, School of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Postoperative nausea and vomiting (PONV), as one of the complications after laparoscopic cholecystectomy, occurs in over 40% - 77% of cases. Considering the numerous complications of synthetic drugs, there is a growing tendency towards the use of herbal medicines due to their unique features. Ginger root is one of the herbal compounds effective on nausea and vomiting. Read More

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October 2018

Efficacy of Preoperative Administration of Acetaminophen and Melatonin on Retrobulbar Block Associated Pain in Cataract Surgery.

Anesth Pain Med 2018 Oct 11;8(5):e61041. Epub 2018 Sep 11.

Anesthesiology Research Center, Department of Anesthesiology, Al-Zahral Hospital, Guilan University of Medical Sciences, Rasht , Iran.

Background: Retrobulbar block is one of the chosen methods for local anesthesia in cataract surgery. Since it is a painful procedure, using analgesic and sedative drugs is recommended. Current medications have side effects and evaluating of new drugs or new uses of existing safer drugs is necessary. Read More

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October 2018

Indirect revascularization for moyamoya disease: A pediatric neuroanesthesiology perspective.

Surg Neurol Int 2018 2;9:224. Epub 2018 Nov 2.

Department of Neurosurgery, Division of Pediatric Neurosurgery, Baylor College of Medicine/Texas Children's Hospital, Houston, TX 77030, USA.

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November 2018