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    1 OF 477

    Opioid Abuse or Dependence Increases 30-day Readmission Rates after Major Operating Room Procedures: A National Readmissions Database Study.
    Anesthesiology 2018 Feb 22. Epub 2018 Feb 22.
    From the Department of Anesthesia and Critical Care (A.G., J.N., D.E., S.L.N., A.T., M.M., J.A., S.S.) and the Department of Obstetrics and Gynecology/Section of Maternal Fetal Medicine (A.M.), University of Chicago, Chicago, Illinois; and the Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (A.M.).
    Background: Although opioids remain the standard therapy for the treatment of postoperative pain, the prevalence of opioid misuse is rising. The extent to which opioid abuse or dependence affects readmission rates and healthcare utilization is not fully understood. It was hypothesized that surgical patients with a history of opioid abuse or dependence would have higher readmission rates and healthcare utilization. Read More

    Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.
    Anesthesiology 2018 Feb 19. Epub 2018 Feb 19.
    From the Center for Translational Pain Medicine, Departments of Anesthesiology (R.-R.J., A.N., Y.H., N.T., W.M.) and Neurobiology (R.-R.J.) and Pharmacology (A.N.), Duke University Medical Center, Durham, North Carolina.
    Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity, and increased neuronal responsiveness in central pain pathways after painful insults. Accumulating evidence suggests that central sensitization is also driven by neuroinflammation in the peripheral and central nervous system. A characteristic feature of neuroinflammation is the activation of glial cells, such as microglia and astrocytes, in the spinal cord and brain, leading to the release of proinflammatory cytokines and chemokines. Read More

    Positive End-expiratory Pressure Alone Minimizes Atelectasis Formation in Nonabdominal Surgery: A Randomized Controlled Trial.
    Anesthesiology 2018 Feb 19. Epub 2018 Feb 19.
    From the Department of Anesthesia and Intensive Care (E.Ö., L.E.) and the Department of Radiology (A.T.), Västerås and Köping Hospital, Västerås, Sweden; Center for Clinical Research, Västerås, Sweden (M.E.); Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden (H.Z.); and Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden (G.H.).
    Background: Various methods for protective ventilation are increasingly being recommended for patients undergoing general anesthesia. However, the importance of each individual component is still unclear. In particular, the perioperative use of positive end-expiratory pressure (PEEP) remains controversial. Read More

    Does Aerobic Respiration Produce Carbon Dioxide or Hydrogen Ion and Bicarbonate?
    Anesthesiology 2018 Feb 15. Epub 2018 Feb 15.
    From Medical Service, Veterans Affairs Puget Sound Health Care System, Seattle, Washington; and the Department of Medicine and of Physiology and Biophysics, University of Washington, Seattle, Washington.
    Maintenance of intracellular pH is critical for clinical homeostasis. The metabolism of glucose, fatty acids, and amino acids yielding the generation of adenosine triphosphate in the mitochondria is accompanied by the production of acid in the Krebs cycle. Both the nature of this acidosis and the mechanism of its disposal have been argued by two investigators with a long-abiding interest in acid-base physiology. Read More

    Endothelin Signaling Contributes to Modulation of Nociception in Early-stage Tongue Cancer in Rats.
    Anesthesiology 2018 Feb 15. Epub 2018 Feb 15.
    From the Department of Clinical Medicine (A.F., R.A., Y.Y.) and the Department of Physiology (M.S., A.K., K.H., K.I.), Nihon University School of Dentistry, Tokyo, Japan.
    Background: Patients with early stage tongue cancer do not frequently complain of tongue pain. Endothelin-1 signaling is upregulated in the cancerous tongue at the early stage. We tested the hypothesis that endothelin-1 signaling contributes to the modulation of tongue nociception. Read More

    Pre-anesthetic assessment with three core questions for the detection of obstructive sleep apnea in childhood: An observational study.
    BMC Anesthesiol 2018 Feb 20;18(1):25. Epub 2018 Feb 20.
    Department of Neuropediatric, University Hospital Leipzig, Liebigstr. 20, 04103, Leipzig, Germany.
    Background: Children with obstructive sleep apnea are at high risk for perioperative airway obstruction. Many "at risk" children may remain unrecognized. The aim of this study is to find a clinically practicable test to identify obstructive sleep apnea in childhood. Read More

    Comparative study of ultrasound-guided paravertebral block versus intravenous tramadol for postoperative pain control in percutaneous nephrolithotomy.
    BMC Anesthesiol 2018 Feb 17;18(1):24. Epub 2018 Feb 17.
    Faculty of Medicine, Department of Anaesthesiology and Reanimation, Cukurova University, 01250, Adana, Turkey.
    Background: Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure for renal calculi, and nephrostomy tubes lead to postoperative pain after PCNL. Regional techniques (e.g. Read More

    The effects of Desflurane and Sevoflurane on Nesfatin-1 levels in laparoscopic Cholecystectomy: a randomized controlled trial.
    BMC Anesthesiol 2018 Feb 16;18(1):23. Epub 2018 Feb 16.
    Yıldırım Beyazıt University Anesthesiology and Reanimation Department, Ankara, Turkey.
    Background: Nesfatin-1 is involved in cardiovascular regulation, stress-related responses. The objective of this study is to investigate the impact of volatile anesthetics on Nesfatin-1 levels.

    Method: Fourty-two patients aged 30-65 years with the American Society Anesthesiology (ASA) Class I-II who were scheduled for laparoscopic cholecystectomy were included in the study Patients were randomized into two group; desflurane administered group (Group I, n = 21) and sevoflurane administered group (Group II, n = 21). Read More

    Use of esophageal balloon pressure-volume curve analysis to determine esophageal wall elastance and calibrate raw esophageal pressure: a bench experiment and clinical study.
    BMC Anesthesiol 2018 Feb 14;18(1):21. Epub 2018 Feb 14.
    Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Address: No 6, Tiantan Xili, Dongcheng district, Beijing, 100050, China.
    Background: Accurate measurement of esophageal pressure (Pes) depends on proper filling of the balloon. Esophageal wall elastance (Ees) may also influence the measurement. We examined the estimation of balloon-surrounding elastance in a bench model and investigated a simplified calibrating procedure of Pes in a balloon with relatively small volume. Read More

    Unusual elevation in Entropy but not in PSI during general anesthesia: a case report.
    BMC Anesthesiol 2018 Feb 14;18(1):22. Epub 2018 Feb 14.
    Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul, 08308, South Korea.
    Background: EEG monitoring is useful for determining an adequate level of anesthesia. However it is sometimes interfered by various reasons. We describe a case in which we successfully confirmed the adequate depth of anesthesia by monitoring the patient state index (PSI), which was computed from the SedLine monitor data in Root (Masimo) during general anesthesia. Read More

    Association of Polypharmacy with Survival, Complications, and Healthcare Resource Use after Elective Noncardiac Surgery: A Population-based Cohort Study.
    Anesthesiology 2018 Feb 14. Epub 2018 Feb 14.
    From the Departments of Anesthesiology and Pain Medicine (D.I.M., G.L.B.) and Internal Medicine (C.v.W.) and the School of Epidemiology and Public Health (D.I.M., C.v.W.), University of Ottawa, Ottawa, Ontario, Canada; the Departments of Anesthesiology and Pain Medicine (D.I.M., G.L.B.) and Internal Medicine (C.v.W.) and the Research Institute (D.I.M., G.L.B., C.v.W.), The Ottawa Hospital, Ottawa, Ontario, Canada; and the Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada (D.I.M., C.A.W., C.v.W.).
    Background: Polypharmacy is increasingly prevalent in older patients and is associated with adverse events among medical patients. The impact of polypharmacy on outcomes after elective surgery is poorly described. The authors' objective was to measure the association of polypharmacy with survival, complications, and resource use among older patients undergoing elective surgery. Read More

    High-fat diet aggravates postoperative cognitive dysfunction in aged mice.
    BMC Anesthesiol 2018 Feb 13;18(1):20. Epub 2018 Feb 13.
    Department of Anesthesia, Zhongshan Hospital affiliated to Fudan University, Shanghai, China.
    Background: Silent Information Regulator 1 (Sirt1) and apoptosis play key roles in postoperative cognitive dysfunction (POCD). Consuming a high-fat diet (HFD), a prevalent type of diet in modern society, has been increasingly recognized as contributing to neurodegenerative diseases. Although Sirt1 and apoptosis are significant responders to HFD in the brain, little is known regarding the functional correlations between HFD and POCD. Read More

    Preoperative versus postoperative ultrasound-guided rectus sheath block for improving pain, sleep quality and cytokine levels in patients with open midline incisions undergoing transabdominal gynecological surgery: a randomized-controlled trial.
    BMC Anesthesiol 2018 02 9;18(1):19. Epub 2018 Feb 9.
    Department of Anesthesiology, the First Hospital of China Medical University, Shenyang, 110001, China.
    Background: Nerve block is usually performed before surgery because it inhibits reflection of the skin incision and reduces the amount of intraoperative anesthetic used. We hypothesized that performing rectus sheath block (RSB) after surgery would result in a longer duration of the analgesic effects and have a subtle influence on sleep time after surgery but that it would not decrease the perioperative cytokine levels of patients undergoing gynecological surgery.

    Methods: A randomized, double-blinded, controlled trial was conducted from October 2015 to June 2016. Read More

    Monitoring of argatroban and lepirudin anticoagulation in critically ill patients by conventional laboratory parameters and rotational thromboelastometry - a prospectively controlled randomized double-blind clinical trial.
    BMC Anesthesiol 2018 02 9;18(1):18. Epub 2018 Feb 9.
    Klinik für Anästhesiologie, Universitätsklinik Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
    Background: Argatroban or lepirudin anticoagulation therapy in patients with heparin induced thrombocytopenia (HIT) or HIT suspect is typically monitored using the activated partial thromboplastin time (aPTT). Although aPTT correlates well with plasma levels of argatroban and lepirudin in healthy volunteers, it might not be the method of choice in critically ill patients. However, in-vivo data is lacking for this patient population. Read More

    Prolonged Catheter Use and Infection in Regional Anesthesia: A Retrospective Registry Analysis.
    Anesthesiology 2018 Feb 8. Epub 2018 Feb 8.
    From the Department of Anesthesiology, Intensive Care Medicine and Pain Medicine (H.B., I.B., T.V., A.R.), and the Institute for Medical Biometry, Epidemiology and Medical Informatics (S.W.), Saarland University, University Medical Center, Homburg/Saar, Germany; the Department of Anesthesiology, Intensive Care and Pain Medicine, Orthopedic University Hospital, Frankfurt, Germany (P.K.); the Department of Anesthesiology and Intensive Care Therapy, Philipps University Marburg, Germany (H.W.); the Department of Anesthesia, Intensive and Palliative Care Medicine, Academic Hospital Solingen, Germany (T.S.); the Department of Anesthesiology, Intensive Care and Pain Medicine, Friederikenstift Hannover, Germany (A.G.); the Department of Anesthesiology and Intensive Care Medicine, Hospital Calw-Nagold, Germany (J.D.); the Department of Anesthesiology, St. Marien-Hospital, Siegen, Germany (W.H.); the Department of Anesthesiology and Operative Intensive Care Medicine, Charité Campus Virchow Klinikum and Campus Mitte, Charité University Medicine Berlin, Germany (J.B., C.S.); the Department of Anesthesiology, Intensive Care and Pain Therapy, University and Rehabilitation Clinics, Ulm, Germany (B.K., J.W.); the Department of Anesthesiology, Intensive Care and Pain Therapy, HELIOS Hospital Erfurt, Germany (S.L.-B.); the Department of Anesthesiology and Intensive Care, Jena University Hospital, Germany (W.M.); the Department of Anesthesiology, Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany (O.V., T.K.); and the Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio (D.I.S.).
    Background: Prolonged catheter use is controversial because of the risk of catheter-related infection, but the extent to which the risk increases over time remains unknown. We thus assessed the time-dependence of catheter-related infection risk up to 15 days.

    Methods: Our analysis was based on the German Network for Regional Anesthesia, which includes 25 centers. Read More

    Comparison of lumbar plexus block using the short axis in-plane method at the plane of the transverse process and at the articular process: a randomized controlled trial.
    BMC Anesthesiol 2018 02 7;18(1):17. Epub 2018 Feb 7.
    Department of Anesthesia, the First Hospital Affiliated to Army Medical University (Southwest Hospital), Army Medical University, Chongqing, 400038, China.
    Background: Although the safety and effectiveness of the short-axis in-plane method has been confirmed for lumbar plexus block, the operation is difficult and has a high rate of epidural spread at the plane of the articular process. Therefore, we developed a new in-plane technique, called the beach chair method, which displays images from the transverse process. We compared the operative difficulty and incidence of epidural spread of the beach chair method with those of the control method (at the plane of the articular process) in this randomized controlled clinical trial. Read More

    Design of a Novel Multifunction Decision Support Display for Anesthesia Care: AlertWatch® OR.
    BMC Anesthesiol 2018 02 5;18(1):16. Epub 2018 Feb 5.
    Department of Anesthesiology, University of Michigan Medicine, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.
    Background: This paper describes the design of a multifunction alerting display for intraoperative anesthetic care. The design was inspired by the multifunction primary flight display used in modern aviation.

    Results: The display retrieves live data from multiple sources; the physiologic monitors, the anesthesia information management system, the laboratory values and comorbidities from patient's problem summary list, medical history or history & physical. Read More

    Buprenorphine Depresses Respiratory Variability in Obese Mice with Altered Leptin Signaling.
    Anesthesiology 2018 Feb 2. Epub 2018 Feb 2.
    From the Departments of Anesthesiology (C.A., Z.T.G., W.A., S.M., H.A.B., R.L.), Psychology (Z.T.G., H.A.B., R.L.), and Information Technology (J.P.), University of Tennessee, Knoxville, Tennessee; Oak Ridge National Laboratory, Oak Ridge, Tennessee (H.A.B., R.L.); and Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee (Y.J.).
    Background: Opiate-induced respiratory depression is sexually dimorphic and associated with increased risk among the obese. The mechanisms underlying these associations are unknown. The present study evaluated the two-tailed hypothesis that sex, leptin status, and obesity modulate buprenorphine-induced changes in breathing. Read More

    Hypertension, mitral valve disease, atrial fibrillation and low education level predict delirium and worst outcome after cardiac surgery in older adults.
    BMC Anesthesiol 2018 02 1;18(1):15. Epub 2018 Feb 1.
    Heart Institute (InCor), University of Sao Paulo, Brazil. Av. Dr. Enéas Carvalho de Aguiar 44, Sao Paulo, CEP, São Paulo, 05403-000, Brazil.
    Background: Delirium is a common complication after cardiac surgery in older adult patients. However, risk factors and the influence of delirium on patient outcomes are not well established. We aimed to determine the incidence, predisposing and triggering factors of delirium following cardiac surgery. Read More

    18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.
    Anesthesiology 2018 02 1. Epub 2018 Feb 1.
    From the Department of Anesthesiology (R.Y.K., T.B., M.B., N.T., M.F.N., J.P.M.), Department of Radiology (O.G.J., S.B.-N.), Department of Biostatistics and Bioinformatics (Y.-J.L., W.Q.), and the Department of Psychiatry and Behavioral Science (P.M.D.), Duke University, Durham, North Carolina. University of California, San Francisco University of Southern California University of California, San Francisco University of Southern California Mayo Clinic, Rochester Mayo Clinic, Rochester University of California, Berkeley University of Pennsylvania University of Southern California University of California, Davis Brigham and Women's Hospital/Harvard Medical School Indiana University Washington University St. Louis University of Pennsylvania Prevent Alzheimer's Disease 2020 (Chair) Siemens Alzheimer's Association University of Pittsburgh Washington University St. Louis Cornell University Albert Einstein College of Medicine of Yeshiva University AD Drug Discovery Foundation Acumen Pharmaceuticals Washington University St. Louis Northwestern University National Institute of Mental Health Brown University Eli Lilly (Chair) BWH/HMS (Chair) University of Washington (Chair) Mayo Clinic, Rochester (Core Principal Investigator) University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, Davis (Core Principal Investigator) University of California, Davis University of California, San Diego Mayo Clinic, Rochester (Core Principal Investigator) Mayo Clinic, Rochester University of London University of California, Los Angeles School of Medicine University of California, San Francisco Magnetic Resonance Imaging University of California, Davis Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic University of California, Berkeley (Core Principal Investigator) University of Michigan University of Utah Banner Alzheimer's Institute Banner Alzheimer's Institute University of Pittsburgh University of California, Berkeley Washington University St. Louis Washington University St. Louis Washington University St. Louis Washington University St. Louis (ASCP) - Past Investigator University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Southern California (Core Principal Investigator) University of Southern California University of Southern California Indiana University Indiana University University of California, Irvine Indiana University Indiana University Indiana University Indiana University University of California, San Francisco University of California, San Diego Prevent Alzheimer's Disease 2020 University of California, San Diego National Institute on Aging University of California, San Francisco Brown University National Institute of Mental Health Cornell University Johns Hopkins University Richard Frank Consulting Prevent Alzheimer's Disease 2020 National Institute on Aging Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University University of Southern California University of Southern California University of Southern California University of Southern California University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of Michigan University of Michigan Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Columbia University Medical Center Columbia University Medical Center Columbia University Medical Center Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham University of Alabama - Birmingham Mount Sinai School of Medicine Mount Sinai School of Medicine Rush University Medical Center Rush University Medical Center Wien Center Wien Center Wien Center Johns Hopkins University Johns Hopkins University Johns Hopkins University Johns Hopkins University New York University New York University New York University New York University Duke University Medical Center Duke University Medical Center Duke University Medical Center University of Pennsylvania University of Pennsylvania University of Pennsylvania University of Pennsylvania University of Kentucky University of Kentucky University of Kentucky University of Kentucky University of Kentucky University of Kentucky University of Pittsburgh University of Pittsburgh University of Pittsburgh University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of California, Irvine University of California, Irvine University of California, Irvine University of Texas Southwestern Medical School University of Texas Southwestern Medical School University of Texas Southwestern Medical School Emory University Emory University Emory University University of Kansas, Medical Center University of Kansas, Medical Center University of Kansas, Medical Center University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles Mayo Clinic, Jacksonville Mayo Clinic, Jacksonville Mayo Clinic, Jacksonville Indiana University Indiana University Indiana University Indiana University Indiana University Yale University School of Medicine Yale University School of Medicine Yale University School of Medicine Yale University School of Medicine McGill Univ., Montreal-Jewish General Hospital McGill Univ., Montreal-Jewish General Hospital McGill Univ., Montreal-Jewish General Hospital Sunnybrook Health Sciences, Ontario Sunnybrook Health Sciences, Ontario Sunnybrook Health Sciences, Ontario UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cleveland Clinic Lou Ruvo Center for Brain Health Cleveland Clinic Lou Ruvo Center for Brain Health Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Premiere Research Inst (Palm Beach Neurology) Premiere Research Inst (Palm Beach Neurology) Georgetown University Medical Center Georgetown University Medical Center Georgetown University Medical Center Brigham and Women's Hospital Brigham and Women's Hospital Brigham and Women's Hospital Stanford University Stanford University Stanford University Stanford University Stanford University Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Boston University Boston University Boston University Boston University Boston University Howard University Howard University Howard University Case Western Reserve University Case Western Reserve University Case Western Reserve University Case Western Reserve University University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento Neurological Care of CNY Parkwood Hospital Parkwood Hospital Parkwood Hospital University of Wisconsin University of Wisconsin University of Wisconsin University of California, Irvine - BIC University of California, Irvine - BIC University of California, Irvine - BIC Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Dent Neurologic Institute Dent Neurologic Institute Dent Neurologic Institute Ohio State University Ohio State University Ohio State University Albany Medical College Albany Medical College Albany Medical College Hartford Hospital, Olin Neuropsychiatry Research Center Hartford Hospital, Olin Neuropsychiatry Research Center Hartford Hospital, Olin Neuropsychiatry Research Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Rhode Island Hospital Rhode Island Hospital Rhode Island Hospital Butler Hospital Butler Hospital Butler Hospital UC San Francisco UC San Francisco UC San Francisco Medical University South Carolina Medical University South Carolina Medical University South Carolina St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care Nathan Kline Institute Nathan Kline Institute Nathan Kline Institute University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine Cornell University Cornell University Cornell University Cornell University University of South Florida: USF Health Byrd Alzheimer's Institute University of South Florida: USF Health Byrd Alzheimer's Institute University of South Florida: USF Health Byrd Alzheimer's Institute University of California, San Francisco University of Southern California University of California, San Francisco University of Southern California Mayo Clinic, Rochester Brigham and Women's Hospital/ Harvard Medical School University of California, Davis Mayo Clinic, Rochester University of California, Berkeley Washington University St. Louis Indiana University Perelman School of Medicine, University of Pennsylvania University of Southern California Perelman School of Medicine, University of Pennsylvania University of California, San Francisco Rehabilitation Institute of Chicago, Feinberg School of Medicine, Northwestern University University of Washington (Chair) Core Principal Investigator Mayo Clinic, Rochester (Core Principal Investigator) University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Francisco University of California, San Francisco University of California, San Francisco Neylan Davis (Core Principal Investigator) Neylan San Diego Mayo Clinic, Rochester (Core Principal Investigator) Mayo Clinic, Rochester Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Senjem Berkeley (Core Principal Investigator) University of Michigan University of Utah Banner Alzheimer's Institute Banner Alzheimer's Institute Senjem Berkeley Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania University of Southern California (Core Principal Investigator) University of Southern California University of Southern California Indiana University Indiana University University of California, Irvine Indiana University Indiana University Indiana University Indiana University University of California, San Francisco Department of Defense (retired) University of Southern California University of Southern California University of Southern California University of California, San Diego University of California, San Diego Columbia University Medical Center Columbia University Medical Center Columbia University Medical Center Rush University Medical Center Rush University Medical Center Rush University Medical Center Wien Center Wien Center Wien Center Duke University Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of California, Irvine University of California, Irvine University of California, Irvine Medical University South Carolina Medical University South Carolina Medical University South Carolina Premiere Research Institute (Palm Beach Neurology) Premiere Research Institute (Palm Beach Neurology) Premiere Research Institute (Palm Beach Neurology) University of California, San Francisco University of California, San Francisco University of California, San Francisco University of California, San Francisco Georgetown University Medical Center Georgetown University Medical Center Georgetown University Medical Center Brigham and Women's Hospital Brigham and Women's Hospital Brigham and Women's Hospital Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Howard University Howard University Howard University University of Wisconsin University of Wisconsin University of Wisconsin University of Washington University of Washington University of Washington Stanford University Stanford University Stanford University Stanford University Cornell University Cornell University Cornell University.
    Background: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively.

    Methods: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9). Read More

    Perioperative incidence of airway obstructive and hypoxemic events in patients with confirmed or suspected sleep apnea - a prospective, randomized pilot study comparing propofol/remifentanil and sevoflurane/remifentanil anesthesia.
    BMC Anesthesiol 2018 01 27;18(1):14. Epub 2018 Jan 27.
    Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg-Essen and Universitätsklinikum Essen, Hufelandstr 55, D-45147, Essen, Germany.
    Background: Obstructive sleep apnea (OSA) is a risk factor for perioperative complications but data on anesthesia regimen are scarce.

    Methods: In patients with established or strongly suspected OSA, we assessed in a prospective, randomized design the effects on nocturnal apnea-hypopnea-index (AHI) and oxygen saturation (SpO) of propofol/remifentanil or sevoflurane/remifentanil based anesthesia. Patients were selected by a history for OSA and / or a positive STOP - questionnaire and received general anesthesia using remifentanil (12 μg/kg/h) combined either with propofol (4-6 mg/kg/h, n = 27) or sevoflurane (approx. Read More

    Associations between intraoperative ventilator settings during one-lung ventilation and postoperative pulmonary complications: a prospective observational study.
    BMC Anesthesiol 2018 01 25;18(1):13. Epub 2018 Jan 25.
    Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
    Background: The interest in perioperative lung protective ventilation has been increasing. However, optimal management during one-lung ventilation (OLV) remains undetermined, which not only includes tidal volume (V) and positive end-expiratory pressure (PEEP) but also inspired oxygen fraction (FO). We aimed to investigate current practice of intraoperative ventilation during OLV, and analyze whether the intraoperative ventilator settings are associated with postoperative pulmonary complications (PPCs) after thoracic surgery. Read More

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