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    Effects of lubrication on air-sealing performance of a pediatric cuffed tracheal tube.
    BMC Anesthesiol 2017 Sep 19;17(1):129. Epub 2017 Sep 19.
    Department of Anesthesiology, Mizonokuchi Hospital, Teikyo University School of Medicine, 3-8-3 Mizonokuchi, Takatsu-ku, Kawasaki, 213-8507, Japan.
    Background: Lubrication of cuffed tracheal tubes (CTTs) reduces liquid leakage. However, it is not clear how cuff lubrication influences air leakage. We aimed to test the hypothesis that pretreatment with K-Y jelly, a water-soluble lubricant, would improve the air-sealing performance of pediatric CTTs in a model study. Read More

    Recovery after Nulliparous Birth: A Detailed Analysis of Pain Analgesia and Recovery of Function.
    Anesthesiology 2017 Oct;127(4):684-694
    From the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California.
    Background: The majority of parturients in the United States first return for evaluation by their obstetric practitioner 6 weeks after delivery. As such, there is little granular data on the pain experience, analgesic requirements, and functional recovery during the postpartum period. This prospective observational study was performed to evaluate these factors to provide expectations for patients. Read More

    Epidural Labor Analgesia-Fentanyl Dose and Breastfeeding Success: A Randomized Clinical Trial.
    Anesthesiology 2017 Oct;127(4):614-624
    From the Department of Anesthesiology, Memorial Hermann Memorial City Medical Center, Houston, Texas (A.I.L.); Department of Anesthesiology (R.J.M., P.T., M.J.J.) and Center for Healthcare Studies (P.T.), Northwestern University Feinberg School of Medicine, Chicago, Illinois (R.J.M., P.T.); Department of Nursing, Northwestern Memorial Hospital Chicago, Illinois (N.W.); and Department of Anesthesia, University of Iowa Carver College of Medicine, Iowa City, Iowa (C.A.W.).
    Background: Breastfeeding is an important public health concern. High cumulative doses of epidural fentanyl administered for labor analgesia have been reported to be associated with early termination of breastfeeding. We tested the hypothesis that breastfeeding success is adversely influenced by the cumulative epidural fentanyl dose administered for labor analgesia. Read More

    Levosimendan combined with epinephrine improves rescue outcomes in a rat model of lipid-based resuscitation from bupivacaine-induced cardiac arrest.
    BMC Anesthesiol 2017 Sep 15;17(1):128. Epub 2017 Sep 15.
    Department of Anaesthesiology, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang, China.
    Background: The effectiveness of a combination of a lipid emulsion with epinephrine in reversing local anesthetic-induced cardiac arrest has been confirmed. The combination of a lipid emulsion with levosimendan, was shown to be superior to administration of a lipid emulsion alone with regard to successful resuscitation. In this study, we compared the reversal effects of levosimendan, epinephrine, and a combination of the two agents in lipid-based resuscitation in a rat model of bupivacaine-induced cardiac arrest. Read More

    Prevalence and Prognosis Impact of Patient-Ventilator Asynchrony in Early Phase of Weaning According to Two Detection Methods.
    Anesthesiology 2017 Sep 14. Epub 2017 Sep 14.
    From the Intensive Care Unit and Respiratory Division (Département "R3S"), Groupe Hospitalier Pitié-Salpêtrière Charles Foix, AP-HP, 75013, Paris, France (C.R-D., C.B., T.P., T.S., A.D.) and Biostatistics, Public Health and Medical Information Department (L.B.), Assistance Publique-Hoôpitaux de Paris, Groupe Hospitalier Pitieé-Salpeêtrieère Charles Foix, Paris, France; INSERM and UPMC, University Paris 6-Pierre et Marie Curie, UMR_S 1158, "Neurophysiologie Respiratoire Expérimentale et Clinique", Paris, France (C.R.-D., C.B., T.P., T.S., A.D.), Sorbonne Universités, University Paris 6-Pierre et Marie Curie, Paris, France (L.B.); Intensive Care Unit, CHU Limoges, 87042 Limoges Cedex, France (M.C.); Intensive Care Unit, Department of Anesthesiology, Critical Care and Perioperative Medicine, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France (S.P.); R2D2 EA-7281, Université d'Auvergne, Clermont-Ferrand, France (S.P.); CHU de Caen, Department of Intensive Care, Caen, France (N.T.); Medical ICU, Angers University Hospital, Angers, France (A.K.).
    Background: Patient-ventilator asynchrony is associated with a poorer outcome. The prevalence and severity of asynchrony during the early phase of weaning has never been specifically described. The authors' first aim was to evaluate the prognosis impact and the factors associated with asynchrony. Read More

    Impact of Public Reporting of 30-day Mortality on Timing of Death after Coronary Artery Bypass Graft Surgery.
    Anesthesiology 2017 Sep 13. Epub 2017 Sep 13.
    From the Department of Anesthesiology, Columbia University College of Physicians and Surgeons (M.H., V.M., H.W.); Department of Critical Care Medicine, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada (D.C.S., H.W.); Department of Medicine, Interdepartmental Division of Critical Care (D.C.S.), Department of Anesthesia (H.W.), and Interdisciplinary Department of Critical Care Medicine (H.W.), University of Toronto, Toronto, Ontario, Canada; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Z.C.); and Department of Critical Care Medicine, Sunnybrook Research Institute, Toronto, Ontario, Canada (R.P., H.W.).
    Background: Recent reports have raised concerns that public reporting of 30-day mortality after cardiac surgery may delay decisions to withdraw life-sustaining therapies for some patients. The authors sought to examine whether timing of mortality after coronary artery bypass graft surgery significantly increases after day 30 in Massachusetts, a state that reports 30-day mortality. The authors used New York as a comparator state, which reports combined 30-day and all in-hospital mortality, irrespective of time since surgery. Read More

    A Retrospective Analysis of the Clinical Effectiveness of Supraclavicular, Ultrasound-guided Brachiocephalic Vein Cannulations in Preterm Infants.
    Anesthesiology 2017 Sep 13. Epub 2017 Sep 13.
    From the Department of Anesthesia, Klinikum Klagenfurt, Klagenfurt, Austria (C.B., G.G., S.N., M.K., R.L.); Department of Anesthesia, Krankenhaus Spittal/Drau, Spittal/Drau, Austria (R.J.); Department of Statistics, University of Klagenfurt, Klagenfurt, Austria (H.S.); Department of Anatomy, Medical University of Graz, Graz, Austria (G.F.); Department of Neurorehabilitation, Krankenhaus Hermagor, Hermagor, Austria (C.S.).
    Background: The aim of this retrospective analysis was to evaluate the clinical effectiveness of the supraclavicular ultrasound-guided cannulation of the brachiocephalic vein in preterm infants.

    Methods: The ultrasound probe was placed in the supraclavicular region so as to obtain the optimum sonographic long-axis view of the brachiocephalic vein. By using a strict in-plane approach the brachiocephalic vein was cannulated by advancing a 22- or 24-gauge iv cannula from lateral to medial under the long axis of the ultrasound probe under real-time ultrasound guidance into the vein. Read More

    Malignant Hyperthermia in the Post-Genomics Era: New Perspectives on an Old Concept.
    Anesthesiology 2017 Sep 12. Epub 2017 Sep 12.
    From the Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada (S.R., N.K.); and the Department of Anaesthesia, University of Leeds, Leeds, United Kingdom (P.M.H.).
    This article reviews advancements in the genetics of malignant hyperthermia, new technologies and approaches for its diagnosis, and the existing limitations of genetic testing for malignant hyperthermia. It also reviews the various RYR1-related disorders and phenotypes, such as myopathies, exertional rhabdomyolysis, and bleeding disorders, and examines the connection between these disorders and malignant hyperthermia. Read More

    Disruption of Hippocampal Multisynaptic Networks by General Anesthetics.
    Anesthesiology 2017 Sep 12. Epub 2017 Sep 12.
    From the Department of Physiology and Pharmacology (M.-C.K.) and the Department of Physiology and Pharmacology and Program in Neuroscience (L.S.L.), The University of Western Ontario, London, Ontario, Canada.
    Background: Previous studies showed that synaptic transmission is affected by general anesthetics, but an anesthetic dose response in freely moving animals has not been done. The hippocampus provides a neural network for the evaluation of isoflurane and pentobarbital on multisynaptic transmission that is relevant to memory function.

    Methods: Male Long-Evans rats were implanted with multichannel and single electrodes in the hippocampus. Read More

    Malignant Hyperthermia Susceptibility and Related Diseases.
    Anesthesiology 2017 Sep 12. Epub 2017 Sep 12.
    From the Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (R.S.L., S.M.G.); Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada (J.J.D.); and Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada (S.R.).

    Incidence and severity of postoperative sore throat: a randomized comparison of Glidescope with Macintosh laryngoscope.
    BMC Anesthesiol 2017 Sep 12;17(1):127. Epub 2017 Sep 12.
    Department of Anesthesiology, King Khalid Hospital, Hail, Saudi Arabia.
    Background: Postoperative sore throat (POST) is a common problem following endotracheal (ET) intubation during general anesthesia. The objective was to compare the incidence and severity of POST during routine intubation with Glidescope (GL) and Macintosh laryngoscope (MCL).

    Methods: One hundred forty adult patients ASA I and II with normal airway, scheduled to undergo elective surgery under GA requiring ET intubation were enrolled in this prospective randomized study and were randomly divided in two groups, GL and MCL. Read More

    Determination of the optimal inspiratory pressure providing adequate ventilation while minimizing gastric insufflation using real-time ultrasonography in Chinese children: a prospective, randomized, double-blind study.
    BMC Anesthesiol 2017 Sep 11;17(1):126. Epub 2017 Sep 11.
    Department of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children Hospital of Wenzhou Medical University, West College Road 109, Wenzhou, 325027, China.
    Background: During facemask ventilation, gastric insufflation is defined as appearance of a comet-tail or an acoustic shadow on ultrasonography. Ultrasonographic measurement of antral cross-section area (CSA) may reflect an insufflated antrum and provide interesting semi-quantitative data in regard to the gastric insufflation. This study aimed to determine the appropriate level of inspiratory pressure sufficient to provide adequate pulmonary ventilation with a lower occurrence of gastric insufflation during facemask pressure-controlled ventilation using real-time ultrasonography in paralyzed children. Read More

    Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients.
    Anesthesiology 2017 Sep 8. Epub 2017 Sep 8.
    From the Harvard Medical School, Boston, Massachusetts (D.J.C., D.F., J.L.R., H.J., A.M.B., B.T.H., D.B., G.C.); Departments of Anesthesiology, Perioperative and Pain Medicine (D.J.C., D.F., M.C.F., C.-C. H., A.M.B., G.C.), Medicine (J.L.R., H.J.), Orthopedic Surgery (J.W.), Brigham and Women's Hospital, Boston, Massachusetts; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts (B.T.H.); Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts (D.B.); and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts (D.B.).
    Background: The American College of Surgeons and the American Geriatrics Society have suggested that preoperative cognitive screening should be performed in older surgical patients. We hypothesized that unrecognized cognitive impairment in patients without a history of dementia is a risk factor for development of postoperative complications.

    Methods: We enrolled 211 patients 65 yr of age or older without a diagnosis of dementia who were scheduled for an elective hip or knee replacement. Read More

    Implementing a Health System-wide Patient Blood Management Program with a Clinical Community Approach.
    Anesthesiology 2017 Sep 7. Epub 2017 Sep 7.
    From the Department of Anesthesiology and Critical Care Medicine (S.M.F., W.W.Y., P.J.P.), Department of Medicine (R.N.T., L.C.R.), Department of Pathology, Transfusion Medicine (S.J.P., J.L., T.A.F., P.M.N.), Armstrong Institute for Patient Safety and Quality (K.H.K.L., T.L.W., P.A.W., R.D., P.J.P.), and Department of Otolaryngology Head and Neck Surgery (L.E.I.), The Johns Hopkins Medical Institutions, Baltimore, Maryland.
    Background: Patient blood management programs are gaining popularity as quality improvement and patient safety initiatives, but methods for implementing such programs across multihospital health systems are not well understood. Having recently incorporated a patient blood management program across our health system using a clinical community approach, we describe our methods and results.

    Methods: We formed the Johns Hopkins Health System blood management clinical community to reduce transfusion overuse across five hospitals. Read More

    Effect of Xenon Anesthesia Compared to Sevoflurane and Total Intravenous Anesthesia for Coronary Artery Bypass Graft Surgery on Postoperative Cardiac Troponin Release: An International, Multicenter, Phase 3, Single-blinded, Randomized Noninferiority Trial.
    Anesthesiology 2017 09 5. Epub 2017 Sep 5.
    From the Sector Cardiothoracic Anesthesiology, Thorax Centre, Rotterdam, The Netherlands (J. Hofland, I.d.L.); Service d'Anesthésie-Réanimation II, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France (A.O.); Louis Pradel University Hospital, Lyon, France and Department of Anesthesiology and Intensive Care Medicine and Inserm U1060, Faculty of Medicine, Claude Bernard Lyon 1 University, Lyon, France (J.-L.F.); Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany (M.G., B.B.); Air Liquide Santé International, Paris-Saclay Research Center, Jouy-en-Josas, France (J. Hazebroucq); Department of Anesthesia, Hôpital Pontchaillou, Centre Hospitalier Universitaire de Rennes, Rennes, France (C.E.); Department of Anesthesia and Intensive Care, Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Bron, France (P.J.); Department of Anesthesiology and Intensive Care Medicine, University of Lübeck, Lübeck, Germany (M.H.); Service d'Anesthésie Réanimation Chirurgicale, Nouvel Hôpital Civil, Centre Hospitalier Régional Universitaire de Strasbourg, Strasbourg, France (A.S.); Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany (M.C.); Department of Anesthesia and Intensive Care, Institut de Cardiologie - Chirurgie Cardiaque, Hôpital Pitié Salpetrière, Paris, France (J.A.); Service d'Anesthésie et Réanimation Chirurgicale, Hôpital G&R Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes, France (B.R.); Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany (P.M.); Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (B.P.); Service d'Anesthésie et Réanimation Chirurgicale, Centre Hospitalier Universitaire de Caen, Caen, France (J.-L.H.); Department of Anesthesia and Intensive Care, Policlinico "Umberto I," "La Sapienza," University of Rome, Rome, Italy (L.T.); Department of Anesthesiology and Intensive Care, Klinikum Links der Weser gGmbH, Bremen, Germany (P.T.); Chirurgie Cardiovasculaire - Service de Réanimation, Centre Hospitalier Universitaire de Toulouse, Hospitalier de Rangueil, Toulouse, France (H.B.); and Clinic for Anesthesia and Critical Care Medicine, University Hospital Rostock, Rostock, Germany (J.P.R). Service d'Anesthésie et Réanimation Chirurgicale, Centre Hospitalier Universitaire de Caen, Caen, France Departments of Anesthesiology and Cardiothoracic Surgery, Thorax Centre, Rotterdam, The Netherlands Departments of Anesthesiology and Cardiothoracic Surgery, Thorax Centre, Rotterdam, The Netherlands Departments of Anesthesiology and Cardiothoracic Surgery, Thorax Centre, Rotterdam, The Netherlands Service d'Anesthésie-Réanimation II, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France Universitäts Klinikum Schleswig-Holstein, Klinik für Anästhesiologie und Operative Intensivmedizin, Campus Kiel, Kiel, Germany Universitäts Klinikum Schleswig-Holstein, Klinik für Anästhesiologie und Operative Intensivmedizin, Campus Kiel, Kiel, Germany Universitäts Klinikum Schleswig-Holstein, Klinik für Anästhesiologie und Operative Intensivmedizin, Campus Kiel, Kiel, Germany Universitäts Klinikum Schleswig-Holstein, Klinik für Anästhesiologie und Operative Intensivmedizin, Campus Kiel, Kiel, Germany Universitäts Klinikum Schleswig-Holstein, Klinik für Anästhesiologie und Operative Intensivmedizin, Campus Kiel, Kiel, Germany Air Liquide Santé International, Jouy-en-Josas, France Department of Anesthesia, Hôpital Pontchaillou, Rennes, France Department of Anesthesia, Hôpital Pontchaillou, Rennes, France Department of Anesthesia, Hôpital Pontchaillou, Rennes, France Department of Anesthesia, Hôpital Pontchaillou, Rennes, France Department of Anesthesia and Intensive Care, Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Bron, France Department of Anesthesiology and Intensive Care Medicine, University of Lübeck, Lübeck, Germany Department of Anesthesiology and Intensive Care Medicine, University of Lübeck, Lübeck, Germany Department of Anesthesiology and Intensive Care Medicine, University of Lübeck, Lübeck, Germany Department of Anesthesiology and Intensive Care Medicine, University of Lübeck, Lübeck, Germany Department of Anesthesiology and Intensive Care Medicine, University of Lübeck, Lübeck, Germany Department of Cardiac and Thoracic Vascular Surgery, University of Lübeck, Lübeck, Germany Service d'Anesthésie Réanimation Chirurgicale, Hôpitaux Universitaire de Strasbourg, Strasbourg, France Service d'Anesthésie Réanimation Chirurgicale, Hôpitaux Universitaire de Strasbourg, Strasbourg, France Service d'Anesthésie Réanimation Chirurgicale, Hôpitaux Universitaire de Strasbourg, Strasbourg, France Service d'Anesthésie Réanimation Chirurgicale, Hôpitaux Universitaire de Strasbourg, Strasbourg, France Service d'Anesthésie Réanimation Chirurgicale, Hôpitaux Universitaire de Strasbourg, Strasbourg, France Service d'Anesthésie Réanimation Chirurgicale, Hôpitaux Universitaire de Strasbourg, Strasbourg, France Department of Anaesthesiology, University Hospital RWTH Aachen, Aachen, Germany Department of Anaesthesiology, University Hospital RWTH Aachen, Aachen, Germany Department of Anaesthesiology, University Hospital RWTH Aachen, Aachen, Germany Department of Anaesthesiology, University Hospital RWTH Aachen, Aachen, Germany Department of Anesthesia and Intensive Care, Institut de Cardiologie - Chirurgie Cardiaque, Hôpital Pitié Salpetrière, Paris, France Department of Anesthesia and Intensive Care, Institut de Cardiologie - Chirurgie Cardiaque, Hôpital Pitié Salpetrière, Paris, France Department of Anesthesia and Intensive Care, Institut de Cardiologie - Chirurgie Cardiaque, Hôpital Pitié Salpetrière, Paris, France Department of Anesthesia and Intensive Care, Institut de Cardiologie - Chirurgie Cardiaque, Hôpital Pitié Salpetrière, Paris, France Service d'Anesthésie et Réanimation Chirurgicale, Hôpital G&R Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes, France Service d'Anesthésie et Réanimation Chirurgicale, Hôpital G&R Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes, France Service d'Anesthésie et Réanimation Chirurgicale, Hôpital G&R Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes, France Service d'Anesthésie et Réanimation Chirurgicale, Hôpital G&R Laënnec, Centre Hospitalier Universitaire de Nantes, Nantes, France Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Anesthesia and Intensive Care, Policlinico "Umberto I," "La Sapienza," University of Rome, Rome, Italy Department of Anesthesia and Intensive Care, Policlinico "Umberto I," "La Sapienza," University of Rome, Rome, Italy Department of Anesthesia and Intensive Care, Policlinico "Umberto I," "La Sapienza," University of Rome, Rome, Italy Chirurgie Cardiovasculaire - Service de Réanimation, Centre Hospitalier Regional Universitaire, Hospitalier de Rangueil, Toulouse, France Clinic for Anesthesia and Critical Care Medicine, University Hospital of Rostock, Rostock, Germany Clinic for Anesthesia and Critical Care Medicine, University Hospital of Rostock, Rostock, Germany.
    Background: Ischemic myocardial damage accompanying coronary artery bypass graft surgery remains a clinical challenge. We investigated whether xenon anesthesia could limit myocardial damage in coronary artery bypass graft surgery patients, as has been reported for animal ischemia models.

    Methods: In 17 university hospitals in France, Germany, Italy, and The Netherlands, low-risk elective, on-pump coronary artery bypass graft surgery patients were randomized to receive xenon, sevoflurane, or propofol-based total intravenous anesthesia for anesthesia maintenance. Read More

    Stem Cell-based Therapies for Sepsis.
    Anesthesiology 2017 Sep 5. Epub 2017 Sep 5.
    From the Department of Anaesthesia, Galway University Hospitals and National University of Ireland, Galway, Ireland (C.K., J.G.L.); Department of Anesthesia, Keenan Research Centre for Biomedical Sciences, St. Michael's Hospital, Toronto, Ontario, Canada (M.J., J.G.L.); and Departments of Anesthesia, Physiology, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada (J.G.L.).
    Sepsis is a life-threatening syndrome resulting in shock and organ dysfunction stemming from a microbial infection. Sepsis has a mortality of 40% and is implicated in half of all in-hospital deaths. The host immune response to microbial infection is critical, with early-phase sepsis characterized by a hyperinflammatory immune response, whereas the later phase of sepsis is often complicated by suppression. Read More

    Xenon and Cardioprotection: Is This the Light at the End of the Tunnel?
    Anesthesiology 2017 Sep 5. Epub 2017 Sep 5.
    From the Departments of Anesthesia (Y.L.M.), Health Research Methods, Evidence, and Impact (Y.L.M., R.W.), and Surgery (R.W.), Michael DeGroote School of Medicine Faculty of Health Sciences, McMaster University, Hamilton, Canada; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Perioperative Medicine and Surgical Research Unit, Hamilton, Canada (Y.L.M., S.S., R.W.); and University of Bari School of Medicine and Surgery, Hospital Policlinico, Bari, Italy (S.S.).

    A Random-allocation Graded Dose-Response Study of Norepinephrine and Phenylephrine for Treating Hypotension during Spinal Anesthesia for Cesarean Delivery.
    Anesthesiology 2017 Sep 5. Epub 2017 Sep 5.
    From the Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.
    Background: Norepinephrine has been investigated as a potential alterative to phenylephrine for maintaining blood pressure during spinal anesthesia for cesarean delivery with the advantage of less depression of maternal heart rate and cardiac output. However, the relative potencies of these two vasopressors have not been fully determined in this context.

    Methods: In a random-allocation, graded dose-response study, 180 healthy patients undergoing spinal anesthesia for elective cesarean delivery received a single bolus of norepinephrine in one of six different doses ranging from 4 to 12 µg or phenylephrine in one of six different doses ranging from 60 to 200 µg to treat the first episode of hypotension. Read More

    Comparison of the Supreme™ and ProSeal™ laryngeal mask airways in infants: a prospective randomised clinical study.
    BMC Anesthesiol 2017 Sep 5;17(1):125. Epub 2017 Sep 5.
    Department of Paediatric Surgery, Sisli Hamidiye Etfal Education and Research Hospital, Halaskargazi Cad., Etfal Sok, 34377, Istanbul, Turkey.
    Background: The Supreme™ and ProSeal™ laryngeal mask airways (LMAs) are widely used in paediatric anaesthesia; however, LMA use in infants is limited because many anaesthesiologists prefer to use tracheal intubation in infants. In this study, we compared the Supreme and ProSeal LMAs in infants by measuring their performance characteristics, including insertion features, ventilation parameters, induced changes in haemodynamics and rates of postoperative complications.

    Methods: Infants of ASA physical status I scheduled for elective, minor, lower abdominal surgery were divided into two groups: the Supreme LMA group and the ProSeal LMA group. Read More

    TREK-1 mediates isoflurane-induced cytotoxicity in astrocytes.
    BMC Anesthesiol 2017 Sep 5;17(1):124. Epub 2017 Sep 5.
    Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
    Background: There are growing concerns that anaesthetic exposure can cause extensive apoptotic degeneration of neurons and the impairment of normal synaptic development and remodelling. However, little attention has been paid to exploring the possible cytotoxicity of inhalation anaesthetics, such as isoflurane, in astrocytes. In this research, we determined that prolonged exposure to an inhalation anaesthetic caused cytotoxicity in astrocytes, and we identified the underlying molecular mechanism responsible for this process. Read More


    Ten important articles on noninvasive ventilation in critically ill patients and insights for the future: A report of expert opinions.
    BMC Anesthesiol 2017 Sep 4;17(1):122. Epub 2017 Sep 4.
    Department of Biopathology and Medical Biotechnologies (DIBIMED). Section of Anestesia, Analgesia, Intensive Care and Emergency, Policlinico P. Giaccone, University of Palermo, Palermo, Italy.
    Background: Noninvasive ventilation is used worldwide in many settings. Its effectiveness has been proven for common clinical conditions in critical care such as cardiogenic pulmonary edema and chronic obstructive pulmonary disease exacerbations. Since the first pioneering studies of noninvasive ventilation in critical care in the late 1980s, thousands of studies and articles have been published on this topic. Read More

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