24,353 results match your criteria Anesthesiology[Journal]


Major Adverse Cardiac Events and Mortality Associated with Electroconvulsive Therapy: A Systematic Review and Meta-analysis.

Anesthesiology 2019 Jan;130(1):83-91

From the Departments of Anesthesiology and Intensive Care (A.D., M.M., B.P.) Emergency Medicine (H.H.), Medical University of Vienna, Vienna, Austria the Department of Anesthesiology, Washington University, St. Louis, Missouri (P.N.) Department of Public Health Sciences, University of Chicago, University of Chicago, Illinois (T.K.).

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Cardiac events after electroconvulsive therapy have been reported sporadically, but a systematic assessment of the risk is missing. The goal of this study was to obtain a robust estimate of the incidence of major adverse cardiac events in adult patients undergoing electroconvulsive therapy.

Methods: Systematic review and meta-analysis of studies that investigated electroconvulsive therapy and reported major adverse cardiac events and/or mortality. Read More

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January 2019

Supraspinal Mechanisms of Spinal Cord Stimulation for Modulation of Pain: Five Decades of Research and Prospects for the Future.

Anesthesiology 2018 Jul 18. Epub 2018 Jul 18.

From the Department of Anesthesiology and Critical Care Medicine (E.S., D.P.M., S.N.R., Y.G.) the Department of Neurological Surgery (Y.G.) School of Medicine, Johns Hopkins University, Baltimore, Maryland; and the Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (B.L.).

The field of spinal cord stimulation is expanding rapidly, with new waveform paradigms asserting supraspinal sites of action. The scope of treatment applications is also broadening from chronic pain to include cerebral ischemia, dystonia, tremor, multiple sclerosis, Parkinson disease, neuropsychiatric disorders, memory, addiction, cognitive function, and other neurologic diseases. The role of neurostimulation as an alternative strategy to opioids for chronic pain treatment is under robust discussion in both scientific and public forums. Read More

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In Reply.

Anesthesiology 2019 Jan;130(1):174-175

Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois (S.S.).

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January 2019

Association and Effect of Opioid Abuse-Related Readmission.

Authors:
Evan G Pivalizza

Anesthesiology 2019 Jan;130(1):174

UTHealth McGovern Medical School, Houston, Texas.

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January 2019

Morphine, Cocaine, and the Euthanasia of King George V.

Authors:

Anesthesiology 2019 Jan;130(1):105

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January 2019

Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review.

Anesthesiology 2019 Jan;130(1):41-54

From The North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States, University of Pittsburgh Medical Center, Mercy Hospital, Pittsburgh, Pennsylvania (2000 through 2017; M.G.L., B.W.B.) Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida (2018; M.G.L.) Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan (T.T.K., M.T.V., S.K.) Department of Nurse Anesthesia, University of Pittsburgh, Pittsburgh, Pennsylvania (2016 through 2018; B.W.B.) Department of Anesthesiology, School of Medicine (K.G.B., T.W.K., J.C.) School of Public Health (K.G.B.), University of Minnesota, Minneapolis, Minnesota Department of Anesthesiology, Children's Hospital of Pittsburgh (E.L.S.) Department of Anesthesiology (A.H.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Department of Anesthesiology, Weill Cornell Medical College and New York-Presbyterian Hospital, New York, New York (J.L.) Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Canada (S.R.) Department of Anesthesiology and Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Egleston Hospital, Atlanta, Georgia (D.M.). Current positions: Dr. Larach is now at the Department of Anesthesiology, University of Florida, Gainesville, Florida. Dr. Sivak is now at the Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio. Department of Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands Beaumont Health, Dearborn, Michigan Beaumont Health, Royal Oak, Michigan Beaumont Health, Farmington Hills, Michigan Beaumont Health, Grosse Pointe, Michigan Bronson Healthcare, Battle Creek, Michigan Bronson Healthcare, Kalamazoo, Michigan CHOC Children's Hospital, Orange, California Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio Department of Anesthesiology, Columbia University Medical Center, New York, New York Henry Ford Health System, Detroit, Michigan Henry Ford Health System, West Bloomfield, Michigan Holland Hospital, Holland, Michigan Mercy Health, Muskegon, Michigan Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Department of Anesthesiology, Perioperative Care, and Pain Medicine, New York University Langone Medical Center, New York, New York Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, Oregon St. Joseph Mercy, Ann Arbor, Michigan St. Joseph Mercy Oakland, Pontiac, Michigan St. Mary Mercy Hospital, Livonia, Michigan Sparrow Health System, Lansing, Michigan Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California Department of Anesthesiology, University Medical Center Utrecht, Utrecht, The Netherlands Department of Anesthesiology, University of Colorado, Aurora, Colorado Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma Department of Anesthesiology, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology, University of Tennessee Medical Center, Knoxville, Tennessee Department of Anesthesiology, University of Utah, Salt Lake City, Utah Department of Anesthesiology, University of Vermont, Larner College of Medicine, Burlington, Vermont Department of Anesthesiology, University of Virginia, Charlottesville, Virginia Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee Department of Anesthesiology, Wake Forest Baptist Health, Winston-Salem, North Carolina Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri Department of Anesthesiology, Weill Cornell Medical College, New York, New York Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut.

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Although dantrolene effectively treats malignant hyperthermia (MH), discrepant recommendations exist concerning dantrolene availability. Whereas Malignant Hyperthermia Association of the United States guidelines state dantrolene must be available within 10 min of the decision to treat MH wherever volatile anesthetics or succinylcholine are administered, a Society for Ambulatory Anesthesia protocol permits Class B ambulatory facilities to stock succinylcholine for airway rescue without dantrolene. The authors investigated (1) succinylcholine use rates, including for airway rescue, in anesthetizing/sedating locations; (2) whether succinylcholine without volatile anesthetics triggers MH warranting dantrolene; and (3) the relationship between dantrolene administration and MH morbidity/mortality. Read More

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January 2019
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Succinylcholine and Dantrolene: Inseparable in the Emergency Cupboard?

Authors:
Philip M Hopkins

Anesthesiology 2019 Jan;130(1):6-8

From the Malignant Hyperthermia Unit, St. James's University Hospital, Leeds, United Kingdom; and the Institute of Medical Research at St. James's, University of Leeds, Leeds, United Kingdom.

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January 2019

Operation Cancer Resection: Does Anesthetic Approach Matter?

Anesthesiology 2019 Jan;130(1):A17

Vanderbilt University Medical Center Brigham and Women's Health Care/Harvard Medical School.

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January 2019

Science, Medicine, and the Anesthesiologist.

Authors:

Anesthesiology 2019 Jan;130(1):A13-A16

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January 2019

This Month in Anesthesiology.

Authors:

Anesthesiology 2019 Jan;130(1):A1-A2

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January 2019

Anesthesiology.

Authors:

Anesthesiology 2019 Jan;130(1):A7-A8

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January 2019

Anesthesiology.

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Anesthesiology 2019 Jan;130(1):A3-A6

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January 2019

Perioperative surgery- and anaesthesia-related risks of laparoscopic Roux-en-Y gastric bypass - a single centre, retrospective data analysis.

BMC Anesthesiol 2018 Dec 13;18(1):190. Epub 2018 Dec 13.

Institute of Anaesthesiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Background: Conservative obesity treatment often leads to limited results. Bariatric surgery is highly efficient, but the candidates are at risk of developing perioperative complications. Bariatric outcomes have been well described in the past, but there are only few reports of perioperative outcomes. Read More

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December 2018
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Trusted Evidence: Discovery to Practice.

Authors:
Evan D Kharasch

Anesthesiology 2019 Jan;130(1):1-2

From the Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina.

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January 2019

Winner Announced.

Authors:

Anesthesiology 2018 Dec 6. Epub 2018 Dec 6.

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December 2018

Visitor.

Authors:
John Paul Davies

Anesthesiology 2019 Jan;130(1):172-173

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January 2019

Cell salvage using the continuous autotransfusion device CATSmart - an observational bicenter technical evaluation.

BMC Anesthesiol 2018 Dec 12;18(1):189. Epub 2018 Dec 12.

Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

Background: The use of cell salvage and autologous blood transfusion has become an important method of blood conservation. So far, there are no clinical data about the performance of the continuous autotransfusion device CATSmart.

Methods: In total, 74 patients undergoing either cardiac or orthopedic surgery were included in this prospective, bicenter and observational technical evaluation to validate red cell separation process and washout quality of CATSmart. Read More

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December 2018

Left ventricular-arterial coupling is associated with prolonged mechanical ventilation in severe post-cardiac surgery patients: an observational study.

BMC Anesthesiol 2018 Dec 6;18(1):184. Epub 2018 Dec 6.

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Background: Weaning post-cardiac surgery patients from mechanical ventilation (MV) poses a big challenge to these patients. Optimized left ventricular-arterial coupling (VAC) may be crucial for reducing the MV duration of these patients. However, there is no research exploring the relationship between VAC and the duration of MV. Read More

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December 2018

Can apneic oxygen insufflation become a novel lung protective ventilation strategy? A randomized, controlled, blinded, single center clinical trial.

BMC Anesthesiol 2018 Dec 11;18(1):186. Epub 2018 Dec 11.

Affiliated Hospital of Nantong University, No. 20 Xishi Road, 226001, Nantong City, Jiangsu Province, People's Republic of China.

Objective: The aim of this study was to determine whether a AOI strategy on non-ventilated lung could reduce the regional and systemic proinflammatory cytokine and oxidative stress response associated with esophagectomy, and to evaluate whether AOI can be used as a novel lung protective ventilation strategy. Its impact on oxygenation after OLV, surfactant protein A, B, C (SP-A, B, C), postoperative hospital stay and postoperative pulmonary complications (PPCs) was also evaluated.

Methods: Fifty-four adults (ASA II-III) undergoing esophagectomy with OLV were enrolled in the study. Read More

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December 2018

Effects of time delay and body temperature on measurements of central venous oxygen saturation, venous-arterial blood carbon dioxide partial pressures difference, venous-arterial blood carbon dioxide partial pressures difference/arterial-venous oxygen difference ratio and lactate.

BMC Anesthesiol 2018 Dec 11;18(1):187. Epub 2018 Dec 11.

Department of Critical Care Medicine, the Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266000, China.

Background: Central venous oxygen saturation (ScvO), venous-arterial blood carbon dioxide partial pressures difference (Pv-aCO), venous-arterial blood carbon dioxide partial pressures difference/arterial-venous oxygen difference ratio (Pv-aCO/Ca-vO) and lactate are important parameters employed during shock resuscitation. We designed this study to confirm the effects of time delay and body temperature on measurements of these four parameters.

Methods: Arterial and central venous blood samples were simultaneously drawn by plastic syringes via indwelling intra-arterial and central venous catheters from critically ill patients. Read More

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December 2018
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User perceptions of avatar-based patient monitoring: a mixed qualitative and quantitative study.

BMC Anesthesiol 2018 Dec 11;18(1):188. Epub 2018 Dec 11.

Institute of Anesthesiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Background: A new patient monitoring technology called Visual Patient, which transforms numerical and waveform data into a virtual model (an avatar) of the monitored patient, has been shown to improve the perception of vital signs compared to conventional patient monitoring. In order to gain a deeper understanding of the opinions of potential future users regarding the new technology, we have analyzed the answers of two large groups of anesthetists using two different study methods.

Methods: First, we carried out a qualitative analysis guided by the "consolidated criteria for reporting qualitative research" checklist. Read More

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December 2018
1.333 Impact Factor

Anesthesia and Cancer Recurrence: Context for Divergent Study Outcomes.

Anesthesiology 2019 Jan;130(1):3-5

From the Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio (D.I.S.) Peter MacCallum Cancer Centre, Melbourne, Australia Sir Peter MacCallum Department of Oncology and Centre for Integrated Critical Care, University of Melbourne, Parkville, Australia Cancer and Neural-Immune Research Laboratory, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia (B.R.).

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January 2019

Vasoplegia after implantation of a continuous flow left ventricular assist device: incidence, outcomes and predictors.

BMC Anesthesiol 2018 Dec 8;18(1):185. Epub 2018 Dec 8.

Anaesthesiologist, Section of Anaesthesia, Pain Medicine and Intensive Care, Imperial College, London, UK.

Background: Vasoplegia after routine cardiac surgery is associated with severe postoperative complications and increased mortality. It is also prevalent in patients undergoing implantation of pulsatile flow left ventricular assist devices (LVAD). However, less is known regarding vasoplegia after implantation of newer generations of continuous flow LVADs (cfLVAD). Read More

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December 2018

Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering. A randomized controlled trial.

BMC Anesthesiol 2018 Nov 30;18(1):179. Epub 2018 Nov 30.

Department of Anesthesia, Fayoum University, Fayoum, Egypt.

Background: Regional anesthesia could affect the homeostatic system functions resulting frequently in perioperative hypothermia and consequently shivering. The objective of this trial was to evaluate the efficacy of dexmedetomidine and ondansetron to reduce the incidence and severity of shivering after intrathecal blocks.

Methods: This randomized placebo-controlled trial included 120 patients allocated equally in three groups. Read More

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November 2018
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Role of dexamethasone in the para-vertebral block for pediatric patients undergoing aortic coarctation repair. randomized, double-blinded controlled study.

BMC Anesthesiol 2018 Nov 30;18(1):178. Epub 2018 Nov 30.

Department of Anesthesia , Surgical Intensive Care and Pain Management, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: Surgery for aortic coarctation requires special care during anesthesia due to severe pain during the lateral thoracotomy incision, intraoperative hemodynamic instability and the need for large doses of intra- and postoperative analgesics and vasodilators. Additionally, the postoperative care of patients is very important.

Aims: We aimed to compare ultrasound-guided paravertebral block performed using bupivacaine alone and bupivacaine with dexamethasone in terms of the intra- and postoperative analgesic requirements and hemodynamics, postoperative complications and ICU stay. Read More

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November 2018

Glycated hemoglobin A1c level on the day of emergency surgery is a marker of premorbid glycemic control: a retrospective observational study.

BMC Anesthesiol 2018 Nov 30;18(1):180. Epub 2018 Nov 30.

Department of Anesthesiology, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe City, 650-0017, Japan.

Background: Current international guideline recommends to maintain blood glucose level ≤ 180 mg/dL in acute ill patients, irrespective of presence of premorbid diabetes. However, there are studies suggested that optimal acute glycemic control should be adjusted according to premorbid glycemic control in patients with chronic hyperglycemia. Accordingly, to obtain the information of premorbid glycemic control would be relevant. Read More

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November 2018
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Devising negative pressure within intercuff space reduces microaspiration.

BMC Anesthesiol 2018 Dec 3;18(1):181. Epub 2018 Dec 3.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.

Background: Microaspiration past the tracheal tube cuffs causes ventilator-associated pneumonia. The objective of the current study was to evaluate whether creating negative pressure between the tracheal double cuffs could block the fluid passage past the tracheal tube cuffs.

Methods: A new negative pressure system was devised between the double cuffs through a suction hole in the intercuff space. Read More

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December 2018
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Prediction of postoperative mortality in elderly patient with hip fractures: a single-centre, retrospective cohort study.

BMC Anesthesiol 2018 Dec 3;18(1):183. Epub 2018 Dec 3.

Department of Anesthesiology and Peri-operative Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.

Background: Elderly patients are at high risk for postoperative complications and increased mortality after hip fracture (HF) surgery due to frailty and co-morbidities. The prediction of postoperative outcome could be used for clinical decision making. A reliable score to predict postoperative mortality after HF surgery in this sub-population remains unavailable. Read More

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December 2018

In vitro effects of levosimendan on muscle of malignant hyperthermia susceptible and non-susceptible swine.

BMC Anesthesiol 2018 Dec 3;18(1):182. Epub 2018 Dec 3.

Department of Anesthesia and Critical Care, University of Wuerzburg, Oberduerrbacher Str. 6, D-97080, Wuerzburg, Germany.

Background: The calcium sensitizer levosimendan is increasingly used to improve hemodynamics in patients with acutely decompensated heart failure. By binding to cardiac troponin C the conformation of the calcium-troponin C complex is stabilized, which leads to acceleration of actin-myosin crossbrigde formation and increased force generating capacity of muscle fibers. Besides indications in cardiac failure, beneficial effects of levosimendan in skeletal muscle disorders are currently evaluated. Read More

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December 2018

Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study.

Anesthesiology 2018 Nov 27. Epub 2018 Nov 27.

From the Interdepartmental Division of Critical Care Medicine (T.P., J.G.L., E.F., L.J.B.) Department of Anesthesia (J.G.L.) Institute of Health Policy, Management and Evaluation (E.F.) University of Toronto, Toronto, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute (T.P., J.G.L., L.J.B.) Department of Anesthesia (J.G.L.) St. Michael's Hospital, Toronto, Canada Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil (A.S.N.) Department of Intensive Care (A.S.N., M.J.S.) Laboratory of Experimental Intensive Care and Anesthesiology (M.J.S.) Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands; Department of Clinical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy (P.P.) San Martino Policlinico Hospital, Istituto di Ricovero e Cura a Carattere Scientifico for Oncology, Genoa, Italy (P.P.) Department of Anaesthesia, School of Medicine, and Regenerative Medicine Institute at C RAM Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland (J.G.L.) Critical Care Area, Parc Tauli Hospital University, Autonomous University of Barcelona, Barcelona, Spain (C.D.H.) Respiratory Diseases Network Biomedical Investigation Center, Barcelona, Spain (C.D.H., J.A.L., A.A.) Critical Care Department, University Hospital of Getafe, Madrid, Spain (J.A.L.) European University, Madrid, Spain (J.A.L.) School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy (G.B.) Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy (G.B.) Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, Canada (E.F.) Department of Anesthesia, Critical Care and Emergency Medicine, Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico Milan, Milan, Italy (A.P.) Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy (A.P.) Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand (M.J.S.) Critical Care Department, Parc Tauli Health Corporation University, Autonomous University of Barcelona, Sabadell and Intensive Care Department, University Hospitals Sagrado Corazon-General de Cataluña, Quiron Salut, Barcelona-Sant Cugat del Valles, Spain (A.A.).

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes. They represent a relatively poorly characterized population that was only classified as having acute respiratory distress syndrome in the most recent definition. Our primary objective was to describe the natural course and the factors associated with worsening and mortality in this population. Read More

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November 2018
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Development and validation of a predictive risk factor model for epidural re-siting in women undergoing labour epidural analgesia: a retrospective cohort study.

BMC Anesthesiol 2018 Nov 29;18(1):176. Epub 2018 Nov 29.

Department of Women's Anaesthesia, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.

Background: Epidural catheter re-siting in parturients receiving labour epidural analgesia is distressing to the parturient and places them at increased complications from a repeat procedure. The aim of this study was to develop and validate a clinical risk factor model to predict the incidence of epidural catheter re-siting in labour analgesia.

Methods: The data from parturients that received labour epidural analgesia in our centre during 2014-2015 was used to develop a predictive model for epidural catheter re-siting during labour analgesia. Read More

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November 2018
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Effects of prebiotic galacto-oligosaccharide on postoperative cognitive dysfunction and neuroinflammation through targeting of the gut-brain axis.

BMC Anesthesiol 2018 Nov 30;18(1):177. Epub 2018 Nov 30.

Department of Anesthesiology, Peking University School and Hospital of Stomatology, #22 Zhongguancun South Avenue, Beijing, 100081, China.

Background: Surgery-induced neuroinflammation plays an important role in postoperative cognitive dysfunction (POCD). Gut microbiota is a key regulator of neurological inflammation. Nurturing with prebiotics is an effective microbiota manipulation that can regulate host immunity and cognition. Read More

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November 2018

Amisulpride for the Rescue Treatment of Postoperative Nausea or Vomiting in Patients Failing Prophylaxis: A Randomized, Placebo-controlled Phase III Trial.

Anesthesiology 2018 Nov 20. Epub 2018 Nov 20.

From the Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina (A.S.H.) Department of Anaesthesia and Critical Care, University Hospitals of Würzburg, Würzburg, Germany (P.K.) Department of Anesthesiology, Wexner Medical Center at The Ohio State University, Columbus, Ohio (S.D.B.) Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada (F.C.) Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Anesthesiology Institute, Outcomes Research, Fairview Hospital, Cleveland, Ohio (S.A.) Department of Anesthesia, Mount Sinai Hospital, Toronto, Ontario, Canada (N.S.) Department of Anesthesiology, Universitätsklinikum Heidelberg, Heidelberg, Germany (J.M.) Hermann Drive Surgical Hospital, Houston, Texas (D.G.L.) Helen Keller Hospital, Sheffield, Alabama (T.I.M.) Service d'Anesthésie-Réanimation Chirurgicale, CHU de Hautepierre, Strasbourg, France (P.D.) Acacia Pharma Ltd, Cambridge, United Kingdom (G.M.F.) Department of Anesthesiology, Critical Care and Perioperative Medicine, University of Miami, Miami, Florida (K.A.C.).

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Although antiemetics are commonly used to prevent postoperative nausea or vomiting, the failure rate is appreciable and there is currently no generally accepted standard for rescue treatment of postoperative nausea or vomiting after failed prophylaxis. This prospective, randomized, double-blind, parallel-group, placebo-controlled, multicenter study was designed to test the hypothesis that intravenous amisulpride, a dopamine D2/D3-antagonist, is superior to placebo at treating established postoperative nausea or vomiting after failed prophylaxis.

Methods: A total of 2,285 adult patients undergoing surgery under general inhalational anesthesia and receiving standard antiemetic prophylaxis were enrolled at 23 sites in Canada, France, Germany, and the United States. Read More

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November 2018

Levosimendan is superior to epinephrine on coronary flow for lipid-base resuscitation of bupivacaine-induced asystole in the isolated rat heart.

BMC Anesthesiol 2018 Nov 20;18(1):174. Epub 2018 Nov 20.

Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Shangcai village, Nanbaixiang town, Ouhai District, Wenzhou City, 325000, Zhejiang Province, China.

Background: Successful resuscitation from asystole induced by bupivacaine requires the reestablishment of a sufficient coronary flow (CF) quickly. This study was designed to test whether levosimendan was superior to epinephrine in the reestablishment of crucial coronary flows after bupivacaine-induced asystole.

Methods: The isolated, perfused, nonrecirculating, Langendorff rat heart preparation was used. Read More

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November 2018

A case report of multiple anesthesia for pediatric surgery: 80 anesthesia applications in a period of 6 years.

BMC Anesthesiol 2018 Nov 20;18(1):175. Epub 2018 Nov 20.

Şişli Hamidiye Etfal Education and Research Hospital, Anesthesiology and Reanimation Department Halaskargazi Cad. Etfal Sok, Istanbul, Şişli, Turkey.

Background: The side and adverse effects of anesthesia and its neurotoxicity to children have become major concerns of anesthesiologists in recent years. Currently, no clinical trials have provided clear evidence indicating the suitable minimum age for a patient's first anesthetic application, importance of anesthesia duration, number of anesthetic applications or interval between two consecutive anesthesia applications. A very rare case concerning the side, adverse and neurotoxic effects of multiple anesthesia in a child is presented. Read More

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November 2018
3 Reads

Correction to: Comparison of analgesic effect of oxycodone and morphine on patients with moderate and advanced cancer pain: a meta-analysis.

BMC Anesthesiol 2018 Nov 19;18(1):173. Epub 2018 Nov 19.

Department of Pain Management, The Center of Anaesthetized Operation, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing, 100853, China.

After publication of this article [1], the authors noted that the corresponding email address is incorrect. Read More

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November 2018
3 Reads

Sevoflurane preconditioning induces tolerance to brain ischemia partially via inhibiting thioredoxin-1 nitration.

BMC Anesthesiol 2018 Nov 17;18(1):171. Epub 2018 Nov 17.

Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, People's Republic of China.

Background: Sevoflurane preconditioning induces brain ischemic tolerance, but the mechanism remains poorly elucidated. Nitration is an important form of post-translational modification in pathological signaling. This study was to investigate the role of thioredoxin-1 (Trx-1) nitration in neuroprotection effect induced by sevoflurane preconditioning in a transient stroke model in rats. Read More

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November 2018
4 Reads
1.333 Impact Factor

Higher PEEP improves outcomes in ARDS patients with clinically objective positive oxygenation response to PEEP: a systematic review and meta-analysis.

BMC Anesthesiol 2018 Nov 17;18(1):172. Epub 2018 Nov 17.

Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.

Background: Mortality in patients with acute respiratory distress syndrome (ARDS) remains high. These patients require mechanical ventilation strategies that include high positive end-expiratory pressure (PEEP). It remains controversial whether high PEEP can improve outcomes for ARDS patients, especially patients who show improvement in oxygenation in response to PEEP. Read More

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November 2018
5 Reads

Clinical significance and prognosis of serum tenascin-C in patients with sepsis.

BMC Anesthesiol 2018 Nov 15;18(1):170. Epub 2018 Nov 15.

Department of Intensive Care Medicine, Seventh People's Hospital of Shanghai University of TCM, No.358 Datong Road, Gaoqiao Town, Pudong New District, Shanghai, 200137, China.

Background: Tenascin-C is a pro-inflammatory glycoprotein with various biological functions. High expression of tenascin-C is found in inflammation, tissue remodeling, and autoimmune diseases. However, its expression and clinical significance in sepsis remain unclear. Read More

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November 2018

Clinical characteristics and prognosis of serous body cavity effusions in patients with sepsis: a retrospective observational study.

BMC Anesthesiol 2018 Nov 14;18(1):169. Epub 2018 Nov 14.

Department of Emergency Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.

Background: Cavity effusion is common in patients with infectious diseases. However, the incidence rate and characteristics of serous cavity effusions (SCE) in septic patients are not clear to date. The objective of this study was to investigate the incidence and characteristics of SCE in septic patients and to explore the correlations between the bloody effusions and the illness severity/prognosis in septic patients. Read More

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November 2018
8 Reads

Respiratory variation in peripheral arterial blood flow peak velocity to predict fluid responsiveness in mechanically ventilated patients: a systematic review and meta-analysis.

BMC Anesthesiol 2018 Nov 13;18(1):168. Epub 2018 Nov 13.

The department of critical care medicine in the affiliated hospital of Qingdao university, Jiangsu road 16, Qingdao city, 26600, China.

Background: Fluid overloading is detrimental to organ function and results in a poor prognosis. It is necessary to evaluate fluid responsiveness before fluid loading. We performed a systematic meta-analysis to evaluate the diagnostic value of the respiratory variation in peripheral arterial blood flow peak velocity (△Vpeak PA) in predicting fluid responsiveness in mechanically ventilated patients. Read More

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November 2018
5 Reads

When Checklists Fail: Human Factors Learning from Aviation and Safety by Design.

Anesthesiology 2018 Dec;129(6):1192-1193

University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom (M.Z.A.M.).

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December 2018
1 Read