365,915 results match your criteria Anesthesia essays and researches[Journal]


Radiofrequency thoracic sympathectomy for sympathetically maintained chronic post-mastectomy pain, a preliminary report: six months results.

Pain Pract 2020 Jul 6. Epub 2020 Jul 6.

Department of anesthesia and pain management, South Egypt Cancer Institute, Assuit University, Assiut, Egypt.

Aim: Evaluation of the analgesic efficacy of radiofrequency thoracic sympathectomy for sympathetically maintained post-mastectomy pain syndrome (PMPS).

Methods: Patients with PMPS, randomized to group TS, (n = 33) received radiofrequency thoracic sympathectomy or group SHAM, (n = 33). Post-operative pain treatment consisted of duloxetine, pregabalin, and tramadol for both groups. Read More

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http://dx.doi.org/10.1111/papr.12933DOI Listing

Two Hundred Twenty-Six Consecutive Deep Brain Stimulation Electrodes Placed Using an "Asleep" Technique and the Neuro|MateTM Robot for the Treatment of Movement Disorders.

Oper Neurosurg (Hagerstown) 2020 Jul 6. Epub 2020 Jul 6.

Functional Neurosurgery Group, Clinical Neurosciences, University of Bristol, Bristol, United Kingdom.

Background: Robotics in neurosurgery has demonstrated widening indications and rapid growth in recent years. Robotic precision and reproducibility are especially pertinent to the field of functional neurosurgery. Deep brain stimulation (DBS) requires accurate placement of electrodes in order to maximize efficacy and minimize side effects. Read More

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http://dx.doi.org/10.1093/ons/opaa176DOI Listing

Tachykinin Antagonists Reverse Ischemia/Reperfusion Gastrointestinal Motility Impairment in Rats.

J Surg Res 2020 Jul 3;255:510-516. Epub 2020 Jul 3.

Department of Pharmacology, Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Background: Supraceliac aortic clamping and unclamping produces ischemia-reperfusion (I/R) injury of the splanchnic organs. The protective effects of tachykinin receptor antagonists, SR140333 (NK receptor), SR48968 (NK receptor), and SB222200 (NK receptor), against I/R-induced inhibition of intestinal motility were tested in rats.

Material And Methods: The intestinal transit of Evans blue was measured in untreated rats and animals subjected to skin incision, I/R (1 h superior mesenteric artery occlusion followed by 24 h reperfusion) or sham operation. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.092DOI Listing

Early-onset pneumonia following bag-mask ventilation versus endotracheal intubation during cardiopulmonary resuscitation: A substudy of the CAAM trial.

Resuscitation 2020 Jul 3. Epub 2020 Jul 3.

Urgences et Samu 93, AP-HP, Hôpital Avicenne, Inserm U942, 93000 Bobigny, France.

Aim: Early-onset pneumonia (EOP) is a common in-hospital complication in survivors of out-of-hospital cardiac arrest. In this substudy of the CAAM trial, we aimed to compare whether bag mask ventilation (BMV) compared to endotracheal intubation (ETI) performed during cardiopulmonary resuscitation increases the risk of developing EOP.

Methods: Adult patients from the CAAM trial that survived beyond 12 hours of hospitalization were included. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2020.06.011DOI Listing

Development of a Sterile Personal Protective Equipment Donning and Doffing Procedure to Protect Surgical Teams from SARS-CoV-2 Exposure during the COVID-19 Pandemic.

Surg Infect (Larchmt) 2020 Jul 6. Epub 2020 Jul 6.

Department of Medicine, Division of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina, USA.

The coronavirus disease 2019 (COVID-19) pandemic has become an increasingly challenging problem throughout the world. Because of the numerous potential modes of transmission, surgeons and all procedural staff represent a unique population that requires standardized procedures to protect themselves and their patients. Although several protocols have been implemented during other infectious disease outbreaks, such as Ebola virus, no standardized protocol has been published in regard to the COVID-19 pandemic. Read More

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http://dx.doi.org/10.1089/sur.2020.140DOI Listing

Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada.

PLoS Med 2020 Jul 6;17(7):e1003172. Epub 2020 Jul 6.

Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.

Background: The "trimorbidity" of substance use disorder and mental and physical illness is associated with living in precarious housing or homelessness. The extent to which substance use increases risk of psychosis and both contribute to mortality needs investigation in longitudinal studies.

Methods And Findings: A community-based sample of 437 adults (330 men, mean [SD] age 40. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003172DOI Listing

Elucidating the Pivotal Role of Immune Players in the Management of COVID-19: Focus on Mesenchymal Stem Cells and Inflammation.

Curr Stem Cell Res Ther 2020 Jul 5. Epub 2020 Jul 5.

Department of Clinical Medicine, Habana Medical Center, Tamale. Ghana.

The world is currently engulfed with a viral disease with no cure. So, far, millions of people are infected with the virus across the length and breadth of world with thousand losing their lives each passing day. The WHO is February 2020 classified the virus as a coronavirus and the name Coronavirus-19 (CoV-19) was offered to the virus. Read More

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http://dx.doi.org/10.2174/1574888X15666200705213751DOI Listing

Equilibrium Angiotensin Metabolite Profiling in Patients with Acute Respiratory Distress Syndrome Indicates Angiotensin Converting Enzyme Inhibition.

Am J Respir Crit Care Med 2020 Jul 6. Epub 2020 Jul 6.

Medical University of Vienna, 27271, Dept. of Anaesthesia, Critical Care and Pain Medicine, Vienna, Austria;

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http://dx.doi.org/10.1164/rccm.201912-2504LEDOI Listing

Quantitative Tc Labeling Kit for HYNIC-Conjugated Single Chain Antibody Fragments Targeting Malignant Mesothelioma.

Bioconjug Chem 2020 Jul 6. Epub 2020 Jul 6.

Department of Anesthesia, University of California, San Francisco, California 94143, United States.

Single chain antibody fragment (scFv) is a promising agent for imaging and targeted therapy. The objective of the study is to evaluate a kit formulation for Tc labeling of scFv for tumor imaging. The scFv was engineered to contain a cysteine tag to accommodate the specific conjugation of HYNIC and subsequent Tc labeling. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.0c00319DOI Listing

Researches on the protective effect of caffeic acid phenethyl ester on testicular damage caused by cisplatin.

Turk J Med Sci 2020 Jul 6. Epub 2020 Jul 6.

Background/aim: Cisplatin (CP), a chemotherapeutic drug, causes damage to spermatogenic serial cells, Sertoli cells and Leydig cells in rat testicles. We aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE), one of the active ingredients of propolis, in eliminating CP-induced testicular damage.

Materials And Methods: Group 1 (control group) was given Serum Physiological intraperitoneal (ip) throughout the experiment. Read More

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http://dx.doi.org/10.3906/sag-2002-58DOI Listing

Maternal morbidity: how to reduce it.

Curr Opin Anaesthesiol 2020 Aug;33(4):612-617

Department of Anaesthetics, Northwick Park Hospital, Harrow, UK.

Purpose Of Review: Internationally there has been increased interest in maternal morbidity; both as a strategy to reduce maternal deaths and also because of the significant impact on a woman's life as a result of suffering from maternal morbidity. The present review will evaluate the current knowledge of, and strategies to reduce maternal morbidity.

Recent Findings: The study of maternal morbidity and how to reduce it has been hampered for many years by the lack of a standard approach to measurement and evaluation. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000889DOI Listing

Intubation outside of the operating room: new challenges and opportunities in COVID-19 era.

Curr Opin Anaesthesiol 2020 Aug;33(4):608-611

aDepartment of Anesthesia, National University Hospital, Singapore bDepartment of Anesthesia and Pain Management, Toronto General Hospital cDepartment of Anesthesia and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.

Purpose Of Review: Airway management in patients outside the operating room is associated with increased difficulties and risks, and the setting of the COVID-19 global pandemic adds another layer of complexity. Therefore, endotracheal intubation (ETT) of a patient who is presumptive COVID-19 or COVID-19 positive presents an additional challenge to an anesthesiologist. The aim of this review is to summarize the important principles of airway management outside of the operating room during the COVID-19 pandemic. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000892DOI Listing

Recent advances in nonoperating room anesthesia for cardiac procedures.

Curr Opin Anaesthesiol 2020 Aug;33(4):601-607

aDepartment of Anesthesia, National University Hospital, Singapore bDepartment of Anesthesia and Pain Management, Toronto General Hospital, Totonto, Canada.

Purpose Of Review: The number of complex procedures performed in the cardiac catheterization laboratory (CCL) is rapidly increasing. Because of their complexity, they frequently require the assistance of an anesthesiologist. The CCL is primarily designed to facilitate a percutaneous cardiac intervention; therefore, it might be a challenging workplace for an anesthesiologist. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000894DOI Listing

Nonoperating room anesthesia for patients with serious comorbidities.

Authors:
Reino Pöyhiä

Curr Opin Anaesthesiol 2020 Aug;33(4):594-600

Department of Anesthesiology and Intensive Care, University of Helsinki, Helsinki, Finland.

Purpose Of Review: To provide aids to deal with increasing amount of several comorbidities in nonoperating room anesthesia (NORA).

Recent Findings: New indexes for assessment of comorbidities are described and guidelines for the care of patients with obesity, obstructive sleep apnea, chronic obstructive pulmonary disease (COPD), diabetes and COVID19 in NORA summarized.

Summary: In addition to ASA classification, such instruments as Charlson Comorbidity Index, Frailty Index, Surgical Complexity Score and Revised Cardiac Risk could supplement the prospective assessment of the risk of comorbidities. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000890DOI Listing

Nonoperating room anesthesia for children.

Curr Opin Anaesthesiol 2020 Aug;33(4):584-588

Department of Anesthesiology and Critical Care Medicine, Perelman School of Medicine, The University of Pennsylvania and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Nonoperating room anesthesia (NORA) cases performed in pediatric patients have increased over the past decade. It is imperative for the anesthesia provider to be familiar with the nuances of this environment and the myriad of cases to ensure delivery of safe and efficient care.

Recent Findings: Though case volume has increased, sedative agents have largely remained unchanged. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000880DOI Listing

The anesthesiologist and global climate change: an ethical obligation to act.

Curr Opin Anaesthesiol 2020 Aug;33(4):577-583

aDepartment of Anesthesiology and Pain Medicine, Bioethics, University of Washington, Seattle, Washington bDepartment of Anesthesiology, Good Samaritan Hospital, San Jose, California, USA.

Purpose Of Review: Pollution and global warming/climate change contribute to one-quarter of all deaths worldwide. Global healthcare as a whole is the world's fifth largest emitter of greenhouse gases, and anesthetic gases, intravenous agents and supplies contribute significantly to the overall problem. It is the ethical obligation of all anesthesiologists to minimize the harmful impact of anesthesia practice on environmental sustainability. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000887DOI Listing

Risk stratification in patients undergoing nonoperating room anesthesia.

Curr Opin Anaesthesiol 2020 Aug;33(4):571-576

aDepartment of Anaesthesiology and Perioperative Medicine, University Hospital Brussels (UZBrussel) bFaculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Purpose Of Review: A growing numerical and complexity of patients requiring nonoperating room anesthesia (NORA) necessitates a multidisciplinary approach of a highly experienced team in a highly technological setting of the cathlab or radiology suite. These requirements are even more magnified in the context of the coronavirus disease 2019 (COVID-19) pandemic.

Recent Findings: This review describes the aspects of risk stratification both in adults and children with respect to patient morphology, airway management, cardiorespiratory function and finally future developments, which could beneficially interfere with imminent management in NORA. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000888DOI Listing

Is there a place for regional anesthesia in nonoperating room anesthesia?

Curr Opin Anaesthesiol 2020 Aug;33(4):561-565

Département Médico Universitaire de Réanimation Anesthésie Médecine Périopératoire, Site Saint Antoine - Tenon, Sorbonne Université -Faculté de Médecine Paris VI, Paris, France.

Purpose Of Review: General anesthesia and monitored anesthesia care (MAC) are the most widely used techniques in nonoperating room anesthesia (NORA). However, regional anesthesia is slowly finding viable applications in this field. This review aims at providing an update on the current practice of regional anesthesia techniques outside of the operating theatre. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000897DOI Listing

Nonoperating room anaesthesia: safety, monitoring, cognitive aids and severe acute respiratory syndrome coronavirus 2.

Curr Opin Anaesthesiol 2020 Aug;33(4):554-560

aDirector, Department of Anaesthesia and Pain Medicine, St John of God Murdoch Hospital bConsultant Cardiac Anaesthetist and Medical Perfusionist, Department of Anaesthesia, Sir Charles Gairdner Hospital cSenior Lecturer, University of Western Australia, Perth, Western Australia, Australia.

Purpose Of Review: With an ageing population, mounting pressure on the healthcare dollar, significant advances in medical technology, and now in the context of coronavirus disease 2019, the traditional paradigm in which operative procedures are undertaken is changing. Increasingly, procedures are performed in more distant, isolated and less familiar locations, challenging anaesthesiologists and requiring well developed situational awareness. This review looks at implications for the practitioner and patient safety, outlining considerations and steps involved in translation of systems and processes well established in the operating room to more unfamiliar environments. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000895DOI Listing

Standard procedures in nonoperating room anesthesia.

Curr Opin Anaesthesiol 2020 Aug;33(4):539-547

Department of Anesthesiology, Nonoperating Room Anesthesia, Yale University School of Medicine, New Haven, Connecticut, USA.

Purpose Of Review: This article provides an overview of standard procedures currently performed in nonoperating room anesthesia (NORA) and highlights anesthetic implications.

Recent Findings: Novel noninvasive interventional procedures remain on the rise, accelerating demand for anesthesia support outside the conventional operating room. The field of interventional oncology has introduced a variety of effective minimally invasive therapies making interventional radiology gain a major role in the management of cancer. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000898DOI Listing

Nonoperating room anesthesia in different parts of the world.

Curr Opin Anaesthesiol 2020 Aug;33(4):520-526

aYale School of Medicine, New Haven, Connecticut, USA.

Purpose Of Review: Advances in early diagnosis and treatment of diseases using minimally invasive procedures has led to an increase in the number of cases in locations outside the operating room. This surge created the need for anesthesia services to expand to these areas to provide well tolerated and favorable procedural conditions. The present review describes nonoperating room anesthesia patterns in different parts of the world. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000886DOI Listing

Editorial: What will nonoperating room anesthesia look like in the postcoronavirus disease 2019 era?

Authors:
Janusz C Andres

Curr Opin Anaesthesiol 2020 Aug;33(4):518-519

Department of Anaesthesiology and Intensive Therapy, Jagiellonian University Medical College, Krakow, Poland.

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http://dx.doi.org/10.1097/ACO.0000000000000893DOI Listing

The future of neuromuscular blocking agents.

Curr Opin Anaesthesiol 2020 Aug;33(4):490-498

Klinik für Anaesthesiologie und Intensivmedizin, Technische Universität München, Klinikum Rechts der Isar, Ismaninger Straße, München, Germany.

Purpose Of Review: The present review provides a summary of the literature on recent development of new neuromuscular blocking agents and presents clinically well established and new reversal agents.

Recent Findings: Anesthesiologists are still waiting for the ideal neuromuscular blocking agent with a succinylcholine-like rapid onset and offset without side effects. Recent drug development led to a new series of neuromuscular compounds, called the chlorofumarates such as gantacurium, CW002, and CW011. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000891DOI Listing

[Conducting bilateral tonsillectomy in patients after kidney transplantation. Clinical observation].

Vestn Otorinolaringol 2020 ;85(3):83-87

Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.

The experience of performing bilateral tonsillectomy under general anesthesia for two patients with a transplanted kidney receiving immunosuppressive therapy is presented. In both patients after surgery, pain and inflammatory changes in the postsurgery wound were minimal. However, in the postsurgery period, infection was observed in patients, this required the prescription of systemic antibacterial drugs. Read More

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http://dx.doi.org/10.17116/otorino20208503183DOI Listing
January 2020

Persistent cardiac arrest caused by profound hypokalaemia after large-dose insulin injection in a young man with type 1 diabetes mellitus: successful rescue with extracorporeal membrane oxygenation and subsequent ventricular assist device.

Cardiovasc J Afr 2020 Jul 6;31:1-4. Epub 2020 Jul 6.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Email:

A 28-year-old man who had a history of type 1 diabetes mellitus with poor medication compliance was referred to the emergency department of our institute with suspected diabetic ketoacidosis. The patient developed sudden cardiac arrest following continuous insulin administration. Laboratory data revealed severe hypokalaemia. Read More

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http://dx.doi.org/10.5830/CVJA-2020-018DOI Listing

A Single Cell Dissociation Approach for Molecular Analysis of Urinary Bladder in the Mouse Following Spinal Cord Injury.

J Vis Exp 2020 Jun 17(160). Epub 2020 Jun 17.

Department of Urology, Boston Children's Hospital; Department of Surgery, Harvard Medical School;

We describe the implementation of spinal cord injury in mice to elicit detrusor-sphincter dyssynergia, a functional bladder outlet obstruction, and subsequent bladder wall remodeling. To facilitate assessment of the cellular composition of the bladder wall in non-injured control and spinal cord injured mice, we developed an optimized dissociation protocol that supports high cell viability and enables the detection of discrete subpopulations by flow cytometry. Spinal cord injury is created by complete transection of the thoracic spinal cord. Read More

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http://dx.doi.org/10.3791/61455DOI Listing

Electrocardiogram Recordings in Anesthetized Mice using Lead II.

J Vis Exp 2020 Jun 20(160). Epub 2020 Jun 20.

Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University;

The electrocardiogram is a valuable tool for evaluating the cardiac conduction system. Animal research has helped generate novel genetic and pharmacological information regarding the electrocardiogram. However, making electrocardiogram measurements in small animals in vivo, such as mice, has been challenging. Read More

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http://dx.doi.org/10.3791/61583DOI Listing

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy.

J Vis Exp 2020 Jun 18(160). Epub 2020 Jun 18.

Division of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna; Vienna Hepatic Hemodynamic Lab, Medical University of Vienna.

Here we provide a detailed protocol describing the clinical procedure of hepatic venous pressure gradient (HVPG) measurement in patients with advanced chronic liver disease followed by an instruction for transjugular biopsy. Under local anesthesia and ultrasound guidance, a catheter introducer sheath is placed in the right internal jugular vein. Using fluoroscopic guidance, a balloon catheter is advanced into the inferior vena cava (IVC) and inserted into a large hepatic vein. Read More

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http://dx.doi.org/10.3791/58819DOI Listing

Pain in Men Undergoing Transperineal Free-Hand mpMRI Fusion-Targeted Biopsies under Local Anesthesia: Outcomes and Predictors from a Multicenter Study of 1,008 Patients.

J Urol 2020 Jul 6:101097JU0000000000001234. Epub 2020 Jul 6.

Department of Urology, San Giovanni Battista Hospital, AOU Città della Salute e della Scienza and University of Turin, Turin, Italy.

Background: Several TP biopsy series proved feasibility under LA. However, there is a lack of large analysis detailing pain outcomes and factors influencing pain.

Materials And Methods: From 2016 to 2019 we performed a multicenter prospective study in men undergoing mpMRI-TPFBx (target+systematic cores) under LA. Read More

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http://dx.doi.org/10.1097/JU.0000000000001234DOI Listing

Cardiac tamponade: an educational review.

Eur Heart J Acute Cardiovasc Care 2020 Jul 6:2048872620939341. Epub 2020 Jul 6.

University Cardiology, AOU Città della Salute e della Scienza di Torino, Italy.

Cardiac tamponade is a pericardial syndrome characterised by an impairment of the diastolic filling of the ventricles causing reduction of cardiac output, usually producing signs and symptoms of cardiac arrest, if untreated. The main causes of cardiac tamponade include percutaneous cardiac interventions, malignacies, infectious/inflammatory causes, mechanical complications of myocardial infarction and aortic dissection. The diagnosis of cardiac tamponade is a clinical diagnosis based on a suggestive history and clinical presentation with worsening dyspnoea, distended jugular veins, muffled heart sounds and pulsus paradoxus, and should be confirmed by echocardiography. Read More

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http://dx.doi.org/10.1177/2048872620939341DOI Listing

Dexmedetomidine ameliorates postoperative cognitive dysfunction by inhibiting Toll-like receptor 4 signaling in aged mice.

Kaohsiung J Med Sci 2020 Jul 6. Epub 2020 Jul 6.

Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China.

Our study aimed to explore the molecular mechanisms involved in the improvement of postoperative cognitive dysfunction (POCD) by dexmedetomidine (DEX). BV2 microglia cells were cultured under normal condition, DEX exposure (0.1 μg/mL), and lipopolysacchride (LPS) treatment (0. Read More

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http://dx.doi.org/10.1002/kjm2.12234DOI Listing

The analgesic effect of tramadol combined with butorphanol on uterine cramping pain after repeat caesarean section: a randomized, controlled, double-blind study.

J Anesth 2020 Jul 5. Epub 2020 Jul 5.

Department of Neurology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Purpose: This study aimed to explore the effect of patient-controlled intravenous analgesia (PCIA) using tramadol combined with butorphanol on uterine cramping pain in women undergoing repeat caesarean section.

Methods: A total of 126 patients, who were scheduled to undergo repeat caesarean section under spinal anesthesia, were included. PCIA using tramadol combined with butorphanol or sufentanil was randomly performed for postoperative pain control. Read More

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http://dx.doi.org/10.1007/s00540-020-02820-9DOI Listing

The physiology of rowing with perspective on training and health.

Eur J Appl Physiol 2020 Jul 5. Epub 2020 Jul 5.

Department of Anaesthesia, Rigshospitalet, Centre for Clinical Medicine, University of Copenhagen, Rigshospitalet 2043, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Purpose: This review presents a perspective on the expansive literature on rowing.

Methods: The PubMed database was searched for the most relevant literature, while some information was obtained from books.

Results: Following the life span of former rowers paved the way to advocate exercise for health promotion. Read More

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http://dx.doi.org/10.1007/s00421-020-04429-yDOI Listing

Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats.

Mol Med Rep 2020 Jun 16. Epub 2020 Jun 16.

Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

Postoperative cognitive dysfunction (POCD) is a prevalent neurocognitive disorder following surgery and anesthesia, particularly in elderly patients. Isoflurane is a widely used anesthetic agent, which is associated with the development of POCD; however, the precise mechanisms remain unclear. In the present study, aged rats were exposed to 2% isoflurane to establish a POCD model. Read More

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http://dx.doi.org/10.3892/mmr.2020.11244DOI Listing

Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing.

Mol Med Rep 2020 Jun 1. Epub 2020 Jun 1.

Department of Ultrasound, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China.

The study aimed to identify differentially expressed microRNAs (miRNAs/miRs) and explore the mechanisms governing impaired memory and learning ability in developing brains exposed to sevoflurane. A total of six 7‑day‑old male ICR mice were randomly assigned into the sevoflurane anesthesia group (treated with 2.4% sevoflurane) or control group (treated with normal saline solution at the same dose). Read More

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http://dx.doi.org/10.3892/mmr.2020.11199DOI Listing

Rotenone restrains colon cancer cell viability, motility and epithelial‑mesenchymal transition and tumorigenesis in nude mice via the PI3K/AKT pathway.

Int J Mol Med 2020 Aug 10;46(2):700-708. Epub 2020 Jun 10.

Department of Digestion, Rongchang District People's Hospital of Chongqing, Chongqing 402460, P.R. China.

Rotenone, a natural hydrophobic pesticide, has been reported to display anticancer activity in a variety of cancer cells. However, the mechanism of rotenone on colon cancer (CC) cell migration, invasion and metastasis is still unknown. In the present study, the cytotoxicity of rotenone on CC cells were detected by the Cell Counting Kit‑8 assay and confirmed by clone formation assay. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4637DOI Listing

Visual impairment and social isolation, depression and life satisfaction among older adults in Ghana: analysis of the WHO's Study on global AGEing and adult health (SAGE) Wave 2.

BMJ Open Ophthalmol 2020 29;5(1):e000492. Epub 2020 Jun 29.

Community Health, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.

Aim: To estimate the prevalence of visual impairment (VI) and associated factors and further quantify its association with social isolation, depression and life satisfaction among older adults in Ghana.

Methods: WHO Study on Global AGEing and Adult Health Ghana dataset for older adults 50 years and above was used for this study. Social isolation, depression and life satisfaction were our primary outcomes with VI being our secondary outcome. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326267PMC

Verification and Defined Dosage of Sodium Pentobarbital for a Urodynamic Study in the Possibility of Survival Experiments in Female Rat.

Biomed Res Int 2020 11;2020:6109497. Epub 2020 Jun 11.

Department of Anatomy, Jinzhou Medical University, Jinzhou, Liaoning Province, China.

Objectives: To evaluate the effects of pentobarbital dosages on lower urinary tract function and to define an appropriate dosage of sodium pentobarbital that would be suitable for urodynamic studies in which recovery from anesthesia and long term survive were needed for subsequent experiment.

Methods: Twenty-four 8-week-old, female, virgin, Sprague-Dawley rats (200-250 g) were used in this study. Rats in study groups received gradient doses of pentobarbital intraperitoneally, and those in the control group received urethane intraperitoneally. Read More

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http://dx.doi.org/10.1155/2020/6109497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306087PMC

Intrathecal Use of Isobaric Levobupivacaine 0.5% Versus Isobaric Ropivacaine 0.75% for Lower Abdominal and Lower Limb Surgeries.

Cureus 2020 May 31;12(5):e8373. Epub 2020 May 31.

Anesthesiology, K.J. Somaiya Medical College and Hospital, Mumbai, IND.

Background This study was undertaken to compare and evaluate the efficacy of 3-ml 0.5% isobaric levobupivacaine versus 3-ml 0.75% isobaric ropivacaine in patients undergoing elective lower abdominal and lower limb surgeries. Read More

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http://dx.doi.org/10.7759/cureus.8373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328699PMC

Preliminary report of a simulation community of practice needs analysis.

Adv Simul (Lond) 2020 1;5:11. Epub 2020 Jul 1.

Anaesthesia Teaching & Research, Monash University, Melbourne, Australia.

Aim: To understand the current needs related to education and training, and other investment priorities, in simulated learning environments in Australia following a significant period of government funding for simulation-based learning.

Methods: A mixed methods study, comprising qualitative focus groups and individual interviews, followed by a quantitative cross-sectional survey informed by themes emerging from the qualitative data.

Findings: Two focus groups and 22 individual interviews were conducted. Read More

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http://dx.doi.org/10.1186/s41077-020-00130-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329516PMC

The association between low pre-operative step count and adverse post-operative outcomes in older patients undergoing colorectal cancer surgery.

Perioper Med (Lond) 2020 2;9:20. Epub 2020 Jul 2.

Christchurch Public Hospital, University of Otago, Christchurch, New Zealand.

Background: Multiple tools exist estimating perioperative risk. With an ageing surgical demographic, frailty is becoming an increasingly important concept in perioperative medicine due to its association with adverse post-operative outcomes. Reduced physical activity is a hallmark of frailty, and we postulate that a low pre-operative step count may be an objective measure of frailty. Read More

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http://dx.doi.org/10.1186/s13741-020-00150-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330986PMC

Perioperative Point-of-Care Ultrasound and Transesophageal Echocardiography in Resource- Limited Settings-A Focus on Nepal and Bangladesh.

J Cardiothorac Vasc Anesth 2020 Jun 11. Epub 2020 Jun 11.

Department of Anaesthesiology, Tribhuvan University, Kathmandu, Nepal.

The use of point-of-care ultrasound (POCUS) and transesophageal echocardiography (TEE) in the perioperative and critical care setting is increasing worldwide. This increase has been driven by increasing educational opportunities and technologic advances. Nepal and Bangladesh are resource-limited countries where concerted efforts have been made to increase training in POCUS or TEE in the perioperative and critical care settings. Read More

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http://dx.doi.org/10.1053/j.jvca.2020.06.017DOI Listing

Minimally Invasive Esophagectomy In the Modern Era: Is Regional Anesthesia Still the Answer?

J Cardiothorac Vasc Anesth 2020 Jun 10. Epub 2020 Jun 10.

Department of Cardiothoracic Anesthesia, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

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http://dx.doi.org/10.1053/j.jvca.2020.06.016DOI Listing

Interchangeability Between the ClearSight System and Bolus Thermodilution.

J Cardiothorac Vasc Anesth 2020 Jun 12. Epub 2020 Jun 12.

Anesthesiology and Critical Care Department, Amiens University Hospital, Amiens, France; Research Unit on Simplified Care of Complex Surgical Patients, Jules Verne University of Picardy, Centre Universitaire de Recherche en Santé, Amiens, France.

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http://dx.doi.org/10.1053/j.jvca.2020.06.031DOI Listing

Lung, Heart, Vascular, and Diaphragm Ultrasound Examination of COVID-19 Patients: A Comprehensive Approach.

J Cardiothorac Vasc Anesth 2020 Jun 11. Epub 2020 Jun 11.

Department of Medicine, Anesthesia and Intensive Care Clinic, University of Udine, Udine, Italy; Department of Anesthesia and Intensive care, University-Hospital of Udine, Italy, Udine, Italy.

Lung ultrasound (LU) has a multitude of features and capacities that make it a useful medical tool to assist physicians contending with the pandemic spread of novel coronavirus disease-2019 (COVID-19) caused by coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, an LU approach to patients with suspected COVID-19 is being implemented worldwide. In noncritical COVID-19 patients, 2 new LU signs have been described and proposed, the "waterfall" and the "light beam" signs. Read More

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http://dx.doi.org/10.1053/j.jvca.2020.06.013DOI Listing

Effect of Prior Formal Education on Successful Thoracic Epidural Placement By Anesthesia Residents.

J Cardiothorac Vasc Anesth 2020 Jun 12. Epub 2020 Jun 12.

Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN.

Objective: Catheter placement for thoracic epidural analgesia (TEA) is technically challenging; however, methods for teaching this technique to anesthesia residents have not been well-studied. The present study aimed to determine optimal teaching methods for proficient TEA catheter placement by comparing video-based formal resident education with traditional bedside training by attending physicians.

Design: Prospective, randomized study. Read More

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http://dx.doi.org/10.1053/j.jvca.2020.06.023DOI Listing

Better timing of ultrasound-guided transversus abdominis plane block for early recovery after open inguinal herniorrhaphy: A prospective randomised controlled study.

Asian J Surg 2020 Jul 2. Epub 2020 Jul 2.

Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Background: This study investigated the optimal timing of analgesic transversus abdominis plane (TAP) block in the operating room for better recovery quality using the Korean version of the Quality of Recovery-40 (QoR-40K) questionnaire in patients who had undergone open inguinal herniorrhaphy.

Methods: This single-centre, prospective randomised controlled study included adult male patients who had an ASA physical status of I-II. A total of 80 patients were analysed. Read More

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http://dx.doi.org/10.1016/j.asjsur.2020.06.001DOI Listing

Reporting Radical Cystectomy Outcomes Following Implementation of Enhanced Recovery After Surgery Protocols: A Systematic Review and Individual Patient Data Meta-analysis.

Eur Urol 2020 Jul 2. Epub 2020 Jul 2.

USC Institute of Urology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address:

Context: Enhanced Recovery After Surgery (ERAS) is a perioperative approach to managing surgical patients. The impact of ERAS on radical cystectomy (RC) outcomes remains understudied.

Objective: To review the literature regarding ERAS protocols and RC outcomes. Read More

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http://dx.doi.org/10.1016/j.eururo.2020.06.039DOI Listing

A guide to establishing a hyperthermic intraperitoneal chemotherapy program in gynecologic oncology.

Gynecol Oncol 2020 Jul 2. Epub 2020 Jul 2.

Division of Gynecologic Oncology, Obstetrics, Gynecology and Women's Health Institute, Cleveland Clinic, Desk A81, 9500 Euclid Avenue, Cleveland, OH 44195, United States of America.

Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) may be used to treat peritoneal based malignancies, such as epithelial ovarian cancer (EOC). Despite results of clinical trials supporting an increasing indication for HIPEC in EOC, concerns have existed regarding morbidity and challenges with initiating HIPEC at an institutional level. The objective of this review is to describe evidence-based recommendations to guide implementation of a HIPEC program, following our experience at a high-volume tertiary care center. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.06.487DOI Listing

Airway management equipment and practice: time to optimise institutional, team, and personal preparedness.

Br J Anaesth 2020 Jun 17. Epub 2020 Jun 17.

Department of Anaesthesia, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK; Bristol Medical School, University of Bristol, Bristol, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bja.2020.06.012DOI Listing